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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="219"/>
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    </evidence>
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    <accession>H7C786</accession>
    <name>H7C786_BURPS</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
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                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
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                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
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                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
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                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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    </comment>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
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                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
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    <dbReference type="PATRIC" id="fig|272560.6.peg.6734"/>
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    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="18730" checksum="15DD3494216F98B4" modified="2004-10-25" version="1">MPAAIAAPIRDARTHLVHERRPIVNAAEICTREVVACRRTDTVLDAAHLMRDRHVGDLIVVDDAGHAHAPVGMLTDRDIVLSLIAKDVDPAALFVGEIMSAPAAVVHEHDSLWTIAQRMRLTGVRRMPVVNADGALVGMVSVDDLLASVAALFDEIASISRRQIHFEEKARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I23</accession>
    <name>Q63I23_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS2246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552263.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112249.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2246"/>
    <dbReference type="EnsemblBacteria" id="CAH39732">
        <property type="protein sequence ID" value="CAH39732"/>
        <property type="gene ID" value="BPSS2246"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2246"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5847"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLCHAAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="251"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="401"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="642"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="771" mass="82180" checksum="BC7317991F5376B1" modified="2004-10-25" version="1">MANFVRGHAKNYAAVTGFIAIGTLLQAALVRFGGADMPLAPYFPFIAAAAWATSLAGGIAATAASAALAWLLFLNDPAAYPAPLAGRLMQLATFAVVSCAICAIVVALKGSRRANDALRRREAAARRYYETLLQSLTQGVVVSDRHGMLTYMNPSAAALIGCDATAVRGLPFRDVYRAYDGRGARVRASALEHVLRSGRSASVEGHWLAPHDGQRVPIAEAASPLVDSAGDMTGAVLIVRDISIERERSAASQMLRRLVEASPDAIVGVGSNRRITSWNPAARRMFGYDEHAARGCDVAMLIAPRWLRNHPLPESVPDMREPIENVDVLCVRQDGGRMRATMSASPVFDERDACIALSLTLRDTGEQRRRERRVHRSLRGARDARRQADTSNRLKDELLATVSHELRTPLNVIYGWIEVLRNPVDGALQQQAIDAIDRSARSLSRMVGDILDASSLATGKLRLDAMPVDLVRIVNDVTGALGAAAQADGIALSVECALGTCIVSGDGERLRQMLSNLLSNAFKFTPRGGRVTVSLERHDAQAKLTVADTGQGISPEFLPHVFEAFRRAEGAPASPRRGLGLGLSIVRHIAELHGGKVEAASAGKNRGTTFAITLPAGWQPMGALAWAAQAEGGARMTLDAQRILLVDDDATSRASLAAALKTLGAEVVVASSGREAIGKVDAMRPTVVLSDLAMPDGDGYWLLDTLRHVDADADADTRTRAANDAPVLAVTAHAGRDSERRVLAAGFDGYLCKPVDLQTLARAILRATGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I83</accession>
    <name>Q63I83_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pilus assembly-related outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523374.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112189.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2187"/>
    <dbReference type="EnsemblBacteria" id="CAH39672">
        <property type="protein sequence ID" value="CAH39672"/>
        <property type="gene ID" value="BPSS2187"/>
    </dbReference>
    <dbReference type="GeneID" id="56531724"/>
    <dbReference type="KEGG" id="bps:BPSS2187"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5770"/>
    <dbReference type="eggNOG" id="COG4960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DVKLMAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="179" mass="17956" checksum="F31A08C7A6B1022C" modified="2004-10-25" version="1">MLSALPPQPIPLCVTLLAVVAASIDLASRRIPNRLIALGLAGALVAQCALPGPHTGFAAWLAGAATGAGLLLPFYLVRGMAAGDVKLMLAIGAWVGPTLALHIALATFVVGGAWALAVVAGRGRFRKLLANLRHLFAGAALLRVASAARAAPEIDSVGMLPYGVAIAIGTLGVLFAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC9</accession>
    <name>Q63IC9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529365.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112143.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2142"/>
    <dbReference type="EnsemblBacteria" id="CAH39625">
        <property type="protein sequence ID" value="CAH39625"/>
        <property type="gene ID" value="BPSS2142"/>
    </dbReference>
    <dbReference type="GeneID" id="56598170"/>
    <dbReference type="KEGG" id="bps:BPSS2142"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5709"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VELLFVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="193" mass="20999" checksum="3259B361BEDE97CB" modified="2004-10-25" version="1">MVSSTENTRLANAGVALGSKIRALRQRLKRTLDETATAAGISKPFLSQVERGLASPSITSLAGIAHALGVTVQYFVETPSEERSVCRGDQLRFFSFADSANLFARLTNVPEGRQLEAILVRMPPGQKRSEVTTHAGEEFLYVIEGEVSLTLEGKSFVLHAGDSAHYQSTVPHSWVNTAKIESVVVWVGTPRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IT6</accession>
    <name>Q63IT6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111986.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1980"/>
    <dbReference type="EnsemblBacteria" id="CAH39458">
        <property type="protein sequence ID" value="CAH39458"/>
        <property type="gene ID" value="BPSS1980"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1980"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6353"/>
    <dbReference type="eggNOG" id="ENOG5032NZM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RSHATTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="17415" checksum="F6DF494E6C175860" modified="2004-10-25" version="1">MRIRRARFPSRAPSRRARTDTAVTFDYNAAVARQVRFVQCNGLHNVWEEAKMKGIRLVTLAATGLFVLMSSVAHAAGGGHGGGMGGMGGAGGNAGGMSAGHMSRAGMTNTNGFDSGDRDKGIARASDRASTHANLADTQAGRTRSHATTHTTHQHHLGKHLAVGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IU9</accession>
    <name>Q63IU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941085.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111973.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1967"/>
    <dbReference type="EnsemblBacteria" id="CAH39445">
        <property type="protein sequence ID" value="CAH39445"/>
        <property type="gene ID" value="BPSS1967"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1967"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5464"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WMPNFID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="217" mass="23747" checksum="44121172A7AC7F1D" modified="2004-10-25" version="1">MENSLELDKKGRPYGGIAPEARAAERRDALIRAGTRIFGTVGFRRATVRAICQEAKLNDRYFYAAFDGTEALLRCTYEHHAEQLRASVKRAVDALGSSRDGLEARVDAGLAAFFAFLRDACAARVLLLEVMGVSAETDATYQQNLREFGRMIISLAGGVSEDADTRADQRIIGIALVGALTNAGAAWLLTGYRDPEEKMVRNCRKVLLGTLQFLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J03</accession>
    <name>Q63J03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysine-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysP</name>
        <name evidence="8" type="ordered locus">BPSS1913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190875.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111919.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1913"/>
    <dbReference type="EnsemblBacteria" id="CAH39391">
        <property type="protein sequence ID" value="CAH39391"/>
        <property type="gene ID" value="BPSS1913"/>
    </dbReference>
    <dbReference type="GeneID" id="56529670"/>
    <dbReference type="KEGG" id="bps:BPSS1913"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6261"/>
    <dbReference type="eggNOG" id="COG0833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMFSTAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="27"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="520" mass="56145" checksum="4B24EDA62A2232A8" modified="2004-10-25" version="1">MSPHPNSDNSTAQSNPPQLRRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAYLLIGLMVYCLMMSLGEMAAFMPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELVAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNVLTVRGFGEAEYWFALIKVVTVIAFIGVGLLMIFGILKGGPSNGWSNFTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENPRTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKSDVTDVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGMYASTRMLHNLATEGRAPKLFAKLSAGGVPRNALYATTAVGALCFLSSLYGDKTVYLWLLNTSGMTGFIAWLGIALSHYRFRKGYVRQGFSVDQLPYQSSLYPYGPIFAFALCIVIALGQDYQAFLANRIDWIGVLATYVGIPLFLVVWLGYRLVHKTRVVRYEDMDIASWVAEHERAAAHEAREAAAVRVPSSPEAAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J47</accession>
    <name>CHEB2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 2</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB2</name>
        <name type="ordered locus">BPSS1870</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190908.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111875.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63J47"/>
    <dbReference type="SMR" id="Q63J47"/>
    <dbReference type="STRING" id="272560.BPSS1870"/>
    <dbReference type="EnsemblBacteria" id="CAH39347">
        <property type="protein sequence ID" value="CAH39347"/>
        <property type="gene ID" value="BPSS1870"/>
    </dbReference>
    <dbReference type="GeneID" id="56598280"/>
    <dbReference type="KEGG" id="bps:BPSS1870"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5332"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RKFKFDV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225446" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 2">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="342" mass="36134" checksum="E7BA20EC1E01B7DB" modified="2004-10-25" version="1">MNIGIVNDLPLAVEALRRTIALRPEHRVLWVATDGAQALDFCVAQPPDLVLMDLVMPRIDGVSATRSIMERSPCAILIVTANVGANASYVYEAMGAGALDAVDTPTLEQGGSADPSQPLLAKIDQIGRLLATRMPLAAPAAAAPAPQGALPPLVAIGASAGGPTALTALLRRLPDDFPAALVIVQHVDQAFAIGMAQWLDGYSPLPVRIARQGSVPQAGEVLLAATNDHLHLTSRGVLAYTRRPEETPYRPSVDVFFHSVVDHWKGEAIGVLLTGMGRDGALGLKAMRTKGHYTIAQDEATSAVYGMPKAAAAIGAASAVLPLERIADQLISLVQRNRQRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JG1</accession>
    <name>Q63JG1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoD</name>
        <name evidence="11" type="ordered locus">BPSS1755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190933.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111761.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1755"/>
    <dbReference type="EnsemblBacteria" id="CAH39230">
        <property type="protein sequence ID" value="CAH39230"/>
        <property type="gene ID" value="BPSS1755"/>
    </dbReference>
    <dbReference type="GeneID" id="56598180"/>
    <dbReference type="KEGG" id="bps:BPSS1755"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5184"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDAKKEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007631">
        <property type="entry name" value="RNA_pol_sigma_70_non-ess"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04546">
        <property type="entry name" value="Sigma70_ner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="10">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="445"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="524"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="613"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="469"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="680" mass="76745" checksum="261EEDB438D88B4D" modified="2004-10-25" version="1">MTKKLNEVSVDDDANQSDDQPTAASGKGEKAKARDRRAKEKALLKEAFATSTPGTAEELEERRTKLRALIKLGKERGFLTYAEINDHLPDNFTETEALEGIIGTFNDMGVAVYEQAPDAETLLLNDNAPAASSDDEVEEEAEVALSTVDSEFGRTTDPVRMYMREMGTVELLTREGEIEIAKRIEDGLRHMVMAISACPTTIADILAMAERVANEESRVDELVDGLIDPNAADTDGFSEKDAEEIENEDAEAEEDDEEEEEDDDGAAQATANAAQLEALKRASLEKFALISEWFDKMRRAFEKEGYKSKSYLKAQETIQNELMSIRFTARTVERLCDTLRAQVDEVRQVERQILHIVVDKCGMPRSEFIARFPGSETDLDWAEKVAAEGHSYGAILSRNIPAIREQQQRLLDLQARVVLPLKDLKETNRQMAAGELKARQAKREMTEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKMNRISRQILQETGLEPDPATLAEKMEMPEDKIRKIMKIAKEPISMETPIGDDDDSHLGDFIEDTNTVAPADAALHASMRDVVKDVLDSLTPREAKVLRMRFGIEMSTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSDKLKSFLEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JG9</accession>
    <name>Q63JG9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111753.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1747"/>
    <dbReference type="DNASU" id="3095783"/>
    <dbReference type="EnsemblBacteria" id="CAH39222">
        <property type="protein sequence ID" value="CAH39222"/>
        <property type="gene ID" value="BPSS1747"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1747"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6061"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVAHPQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="3">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="11684" checksum="432F2165ED5E8100" modified="2004-10-25" version="1">MSMKIVRSKSFTASRAWGAVDIANMRGITTRLHWTDQPYKWHVNDGEEVFVVLDGRVEMRYRDAGVERSAVLEAGDIFFASVGTEHVACPLGEARILVVETEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JN1</accession>
    <name>Q63JN1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111691.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1686"/>
    <dbReference type="EnsemblBacteria" id="CAH39159">
        <property type="protein sequence ID" value="CAH39159"/>
        <property type="gene ID" value="BPSS1686"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1686"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5984"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYGISRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266330" evidence="1">
        <location>
            <begin position="24"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="726" mass="78587" checksum="EB3183372A34BA14" modified="2004-10-25" version="1">MRRLMRMAVAVCAATALAGAARAENVLPATTSWIGNTYGYGDGTWTQIDIRAIAVAPDGKVYTNAPWDESGAEASVYQDGKMLGFAGGTHGWGNAGGSAIAVNSRYAYVAIAVGNEKGRLVAPGVWPDKGRQWYGISRREIGDVKQAAPFRGAKAGDARAKLAASFLMVNEVPTDTRAEVAGLAASDSVLYASDPLHDAVNVYDAQTMQKKGSWNAHEPGRIALAADGTLWLLTDTLNGPAKLAHVRPDGRAIDDAPALPPDAQAVDVATDAKGRVLLADNGPRQQILIFSKSADGGYAMSGTLGERGGIFSGVAGRPGPQRFNGLTGVGVDRAGNVYVATNGIGPRHGTIGAGLGSTLESYAPDGRLRWQVQGLLFVDGAWIDPGRPNSVYTGNKRFELDLSKPAGKEWKYAGFLSNRFKYPDDPVFNTDQWPGMPFARRVAGRTFLYLTDMHADHLKIYRFDPKRDGETAIPSGLLAGRARPVDKVPNRPPGGDWIWRDANGNGRIDEGEFELNTTGKGMAGGWGWWIDTGGDIWRTSDTRGIRRFRFGGLDKAGNPIYSYDKLTTYPSPAPFTELRRALYDASSDTLYVTGYTADAPRVGGLSKEVGRVLVRFDKWSSGAPVMRYQVALPWRLDAKPIFTLIGLTQEGRYLFGVEPVGTVHVYDKDNGRELGVIKPGPEVGRASGWVDVPFGISAYRRENGEYLVFVEEDARGKVMMYRWRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT0</accession>
    <name>Q63JT0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205656.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111642.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1634"/>
    <dbReference type="EnsemblBacteria" id="CAH39109">
        <property type="protein sequence ID" value="CAH39109"/>
        <property type="gene ID" value="BPSS1634"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1634"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5021"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VGEVEYW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2104"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3188"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2010"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1034"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2139"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="3291" mass="362970" checksum="FBD8B8EDCAC9BF88" modified="2004-10-25" version="1">MTDMLDSSEISVRDDIDPVPGAAPERVLALTAGQYGIWLDQMLNPDLPCYILGAILRIDGTFDEALLTSVVNEVVNANDSLRAMLVSEGGSVRQRVLSDVELEIAHIDFSGSAHPHDSAWRYMRTAFDTAFALDGLLCDFRIVRESPSRTYWMYRCHHLVADGQSVSMICRMIVDLYNRRASADMARIEPTPSYFDSLDDDRKYAESSRYERDAQFWQDKFSSLPPPLLSSRSSEAAARPASFPDGQVNLTIERAKYDRLGRIAEASGCTIVHVMFGVLALYFSRAFQVDEVVIGMPVHNRSTAQQKRAIGMFASVVPIRIPVNGNERFVSLLNGVSAELRHCYRHQRFPIAELNRRLGLVRTGRRQLFDLTLSFEKFPLDFYIGEVKLGLTSMRHRFEQTPITVNVQDYHEDQDLVMQFNYDVNAFSHAEVDNIGTRIGGLLDALIEHHDDMPVGMLPLLDEAERKQVVYEWNATERDYPIEQCIHQLFEAQVDRKPEAIALTFEGQRLSYAELNARANRLAHYLQGRGVGPDRLVALCAERGIEMVVGLLAILKAGGAYVPLDPSHPPERLRRMLDDTNPVAVLVDDIGADALASFESHVAARSPRVHLSRDIAQWRACSPANPSTPRERAARRLAYVIYTSGSSGEPKGVMNEHRGVVNRLWWMQQTYALDERDAVLQKTPFSFDVSVWEFFWPLMSGARLVIAKPEGHKDPAYLSELIDRERVTTLHFVPSMLQAFLEDEGAARGCGSVKRVMCSGEALPPSLVKRFYRCLPDARLHNLYGPTEAAVDVTAWACDAEEGGASVPIGRPIANTRIYVLDGYGQPVPRGVAGELYIGGVQVARGYLNRPELTRERFVDDPFVAGGRLYKTGDLARWRTDGSLEYLGRNDFQVKIRGFRIELGEIEAQLAKVAGVRETVVLARDSGSPAGEKRLVAYYTGNADVAALREQATRHLPAYMVPSAYVRLDAWPLTPNGKLDRRALPAPADDAYARAEYEAPQGAKEEALAAIWKDLLPVERISRHDNFFELGGHSLLVIGLSEKLRAAGLHADVRVVYRASTLADLAAHLGTDNQDIRIPPNLIADGDEHITPAQLTLVALSQESIDALVAKVEGGAANVQDIYPLAPLQEGILFHHLMSGESDPYVLSGVLAFRSREVMERFVSALQQVIDRHDILRTGFFWEGLEQPVQVVQRRATLPVSVVELDAREGDIVRQLEARFDSRGYRMDVSRAPLMHVHAACDGEHERWVARVLFHHLSIDHTTLERVIEEARAIGQGRAEDLPRPVPFRNFVAQARLGVSEADHEAYFRAKLGDIDEPTAPFGLLSVQGDGREIAEAARTLKPELSGALRGHARRLGVSAASMMHVAWGLVLSRTTGRQDVVFGTVLFGRMQGGAQSDRSLGLFINTLPVRMRVAQTGVEASVKGTHAQLAELMRHEHAPLVLAQRCSGVPAQTPLFTSLLNYRYSKPKVAAAHIADGIELLDGHERTSYPLSMTVDDHERDFTIVAKVCERIGPQRVCELMELALEQLTRALSANPGGELAELDVLPAAERTQVLHGWNETGRAYARDACLHQLFEAQVSRTPEAAAVICGDETLSYTDLDARANRLAHYLRGQGVGPDTRVGLALGRGVEMMTGLLAILKAGGAYVPLDPGYASERLRAILDDSRPAIVLADAAGRTALDALAGAPPIADLHADASRWSALPSTPPRVEGLTPRHLAYVIYTSGSTGQPKGVMVEHASVVNLWRALDEAIYRTHPSARRVSLNASIAFDSLVKQWVQLLSGRTLVVVPEPVRFDGRRLLDAIGRDRIDVFDCTPSQLALIEGARGPEDEAFPQVTLVGGEAIGEGMWSELASASSRTYYNVYGPTECTVDATLARITAEHAPHIGGPLANVRAYVLNERLSPAPVGVRGELYIGGAGVARGYLNRPELTRERFIDDPFVAGGRLYRTGDLARWRTDGRLEYLGRNDFQVKIRGFRIELGEIEAQLAKVAGVREVVVLARDSAAAVRDNATEHAAPDALSPSPETSTATATATATEKRLVAYYTGDADVVALRAQAAQHLPSYMVPSAYVRLDAWPLTPNGKLDRRALPAPADDAYARAEYEAPRGAKEEALAAIWRELLHVERVSRHDNFFELGGHSLLAVQLVSRLRQALSVEVALSTVFDAPVLSALAERLEAGNTEVLPPIPLAPRDGRIALSLAQQRLWFLTQLEGVSEAYHMSGAVRLDGPLNREVLQRALNRIVMRHEALRTCFVREEGEPIQVIQPHADLTVSYHDLREAESIRHEAGNREQRAKDLSQAHASAPFDLSRDLPVRVLLLQLADEAHVVQVVMHHIASDGWSVGVFLQELSALYGSFIAEQGDPLAPLPLQYADYAAWQRRWLASGQLEKQGAFWQTNLSGAPTLLELPTDRPRPPKQSHAGASVEVKLGAALSERVKRLSQRHGVTPYMTLLSSWAAALSRLSGQEEVVIGSPVAGRNRTEVEALIGFFVNTLALRLDLSSEPTVGELLKRTKAQVLSAQAHQDLPFDQVVERVKPPRSTAHPPLFQVMFVWQNMPAGELTIPGLTIRAVETPLQTAQFELTLSLREAGDDIVGHLNYASALFDESTVRRYVTYWRRLLEGMTAGAADQTIVGLPLLDEAERKQVVYAWNATERDYPIEQCIHQLFEAQVDRKPEAIALTFDGQRLGYAELNARANRLAHYLQERGVGPDRLVALCAERGIEMVVGLLAILKAGGAYVPLDPSHPPERLRRMLDDTNPVAVLVDDIGADALASFESHVAARSPRVHLSRDIAQWRACSPANPSTPRERAARRLAYVIYTSGSSGEPKGVMNEHRGVVNRLWWMQQTYALDERDAVLQKTPFSFDVSVWEFFWPLMSGARLVIAKPEGHKDPAYLSELIDRERVTTLHFVPSMLQAFLEDEGAARGCGSVKRVMCSGEALPPSLVKRFYRCLPDARLHNLYGPTEAAVDVTAWACDAEEGGASVPIGRPIANTRIYVLDEYGQPVPRGVAGELYIGGVQVARGYLNRPELTRERFVDDPFVAGGRLYKTGDLARWRTDGSLEYLGRNDFQVKIRGFRIELGEIEAQLAKVAGVRETVVLAREAAPDTKRHAASNENSASNSGEKRLVAYYTGDADATALRAQAAQHLPSYMVPSAYVRLDAWPLTPNGKLDRHALPAPADDAYARAEYEAPQGAKEEALAAIWKDLLPVERISRHDNFFELGGHSLLAITLIEHMRRANLHADVTTLFTAPTLADLAVRVGASRGDTYVPPNLIPGDAANGTPESAEVEELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JY4</accession>
    <name>Q63JY4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bcsZ</name>
        <name evidence="6" type="ordered locus">BPSS1581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205644.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111588.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1581"/>
    <dbReference type="EnsemblBacteria" id="CAH39055">
        <property type="protein sequence ID" value="CAH39055"/>
        <property type="gene ID" value="BPSS1581"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1581"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4956"/>
    <dbReference type="eggNOG" id="COG3405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRVYLWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="506" mass="53962" checksum="E7A3BEA33411FA98" modified="2004-10-25" version="1">MARQAGRDEGVGRIGREAGDAREAAGAGEACGRRHARADAWARRASRASRGWRTFWRGRGGVRAVVASVVASFSVMAFAAATLPVSWRVAAAAERTRSGGERAGGLRDTAGLIEISAAAPASTPIPAAPRRFVQPFAQPARAFAAASACAPSWPRWDRFKRDFVSADGRVIDVGSADERTVSEGQAYGLFFALVANDRAAFDALLRWTEDNLAQGDLSARLPAWLWGRAADGAWRVLDANAASDADLWLAYALLEAGRLWRERSYTARGALLAKRVLDEETATLPGLGLVLLPGPTGFRPARDAWRLNPSYSPPQAIRGIGAHVPDDARWARLAAGVGRVLTDSAPRGFAPDWALYRAGRGFEPDAETHAASAYNAIRVYLWAGMLDAGDPLARPLVAHFAPFAEHVAAHGAPPEAVDATTGAAAPRDGNAGFSAAAVPFLEARGERASADAQLARVARLERETASGYYANVLTLFGLGWRDGRYRFAADGTLRVRWSEPCSTPAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K42</accession>
    <name>BOPA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>Effector protein BopA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">bopA</name>
        <name type="ordered locus">BPSS1524</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Microbiology" volume="150" first="2669" last="2676">
            <title>Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis.</title>
            <authorList>
                <person name="Stevens M.P."/>
                <person name="Haque A."/>
                <person name="Atkins T."/>
                <person name="Hill J."/>
                <person name="Wood M.W."/>
                <person name="Easton A."/>
                <person name="Nelson M."/>
                <person name="Underwood-Fowler C."/>
                <person name="Titball R.W."/>
                <person name="Bancroft G.J."/>
                <person name="Galyov E.E."/>
            </authorList>
            <dbReference type="PubMed" id="15289563"/>
            <dbReference type="DOI" id="10.1099/mic.0.27146-0"/>
        </citation>
        <scope>ROLE IN VIRULENCE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>576</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Autophagy" volume="4" first="744" last="753">
            <title>Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines.</title>
            <authorList>
                <person name="Cullinane M."/>
                <person name="Gong L."/>
                <person name="Li X."/>
                <person name="Lazar-Adler N."/>
                <person name="Tra T."/>
                <person name="Wolvetang E."/>
                <person name="Prescott M."/>
                <person name="Boyce J.D."/>
                <person name="Devenish R.J."/>
                <person name="Adler B."/>
            </authorList>
            <dbReference type="PubMed" id="18483470"/>
        </citation>
        <scope>ROLE IN EVADING HOST AUTOPHAGIC PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Plays a role in mediating bacterial evasion from the host autophagic pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <text>Secreted via the bsa type III secretion system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BopA/IcsB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528810.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111530.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63K42"/>
    <dbReference type="STRING" id="272560.BPSS1524"/>
    <dbReference type="PRIDE" id="Q63K42"/>
    <dbReference type="EnsemblBacteria" id="CAH38997">
        <property type="protein sequence ID" value="CAH38997"/>
        <property type="gene ID" value="BPSS1524"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1524"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4878"/>
    <dbReference type="eggNOG" id="ENOG5032XT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSKFICQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011070">
        <property type="entry name" value="Globular_prot_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015203">
        <property type="entry name" value="SptP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044899">
        <property type="entry name" value="SptP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09119">
        <property type="entry name" value="SicP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56568">
        <property type="entry name" value="SSF56568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000344022" description="Effector protein BopA">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15289563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18483470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="512" mass="56832" checksum="CB47108F4B11D8FC" modified="2004-10-25" version="1">MINVDAFVASARSGARVVVGGDARGPVVSAARLGMKERLFAFLAHVPLLKHCDAVRRYAEQVRMENRRSLEVFVLALSKRYGPEGAKAAFDYGARRDGAPLDQRRVRNMVSIAEHFHGTGDAKPLARQMVFRSWECRGLDHPGHASLTIKNQADADAGRHVYEHVSWWPNQRLGSKEHFDRIEPKTLDGYRIDKRSEISSATEQRLREGDAARRKILADGFKYANQDERHDARFFPRAGQKLDKDAEWGLSARKVYFPAIGFNHDRRDTDRPRAFVLFGLNEAAMLRDARTVKEGAKSGELMYQMISKKENCASMALRVLRAGGAEHFVPYTAAWISEDPNHAHAYALAVQARIDALNQRRADVERRCERLRDSASVRQAWRAFSEAGGASASPLAEDAGRGRASAHMRQARLDEHAREVERIGAYFAELSAGRSGKHRDRADAALADAMKRCAPSARDDVAALTRKASVLVETLGRHLDAPPPSDSSALRRLAAHAMIGRIEAFMAAAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KR5</accession>
    <name>Q63KR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202523.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111306.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1297"/>
    <dbReference type="EnsemblBacteria" id="CAH38767">
        <property type="protein sequence ID" value="CAH38767"/>
        <property type="gene ID" value="BPSS1297"/>
    </dbReference>
    <dbReference type="GeneID" id="56597498"/>
    <dbReference type="KEGG" id="bps:BPSS1297"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4583"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVITISR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="7">
        <location>
            <begin position="350"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="489" mass="53724" checksum="D8FBC2D05EA4CD75" modified="2004-10-25" version="1">MPLGYMVIAGAVAVAIVMMSICAAILRDSRDDAFEHAQRAARNTLQMIERDVTRGFRLYDRTLARIAAQFGDRRIAALPAGLRREILFDSAAAANEAGVMYVLDASGHVTLASTRGPLPAERFASYDFFAAQRDTPALGMYLSGPYRMSSRDGEPYVALSRRIERADGAFAGVVVLAVRIAYFRQLLAAANVGPHGALVLMHTDGRILMRIPFDEKFVGLDLTGTSLYSRMQFGRSGEFFDVEPIDHVKRFYLYRRLDDVPLVVQVAIADDDIYATWRLRAWRFGVLTGVFALIFVVMSAYLAHSLWRKSTAEAALARLAGTDSLTGLYNRRALDETLEREWRRAVGGDRPLAILFVDIDHFKRYNDTYGHQVGDEVLATVSRCIAQQAARLGDVVARYGGEEFVVVLPDTPRGGALVVAERVRLGVRMLGIEHEGSEVGFVTVSVGVAVWHPDGASAPHIAAIVEAADQALYRAKADGRNRVVDLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L15</accession>
    <name>Q63L15_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SyrP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539523.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111206.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1196"/>
    <dbReference type="EnsemblBacteria" id="CAH38663">
        <property type="protein sequence ID" value="CAH38663"/>
        <property type="gene ID" value="BPSS1196"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1196"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4430"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEFIYYH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="39668" checksum="907C808537FBEC94" modified="2004-10-25" version="1">MHAPSTPLKLARRQTINVTADSMVRARPLFEDGALPLVVEPELAGVDAPAWIERHGDALAGWLPRHGAILFRGFGIADEAAFHRAVAATGVRLMSYIEKATPREHLGRHIYTSTYFPQEYAIALHNELSYVKAWPGRIFFCCTAPAATGGATPLADVRRVLGRIDPAVRDEFHRRGWQLARCFGSGMGPSWRHAYAVESVDELERYLRAMDVSWQWLPNGWLRTRQVRPAIHTHPRTGDALWFNHVAFWHASSLHEPVRRRFEADFGVESLPYNTYYGDGGTIPDDVAAHLRDAYARETVAFPWRKGDFLIADNMLIAHGRAPFTGERRVLAAMGDAVELDAREMAALRERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L83</accession>
    <name>Q63L83_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="4">DRAP deaminase</shortName>
                <ecNumber evidence="4">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="4">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="4">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="4">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="4"/>
    <dbReference type="EC" id="1.1.1.193" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528345.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111138.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1125"/>
    <dbReference type="EnsemblBacteria" id="CAH38593">
        <property type="protein sequence ID" value="CAH38593"/>
        <property type="gene ID" value="BPSS1125"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1125"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4343"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QGLYTTH"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="3 4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH38593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="395" mass="41591" checksum="3DD06F0E6D0F35BA" modified="2004-10-25" version="1">MSAFSDIDRTHMAHALRLAEQGLYTTHPNPRVGCVIARGARTLGAGWHRRAGEPHAEVHALREAGERARGATAYVTLEPCAHFGRTPPCANALVAAGVARVVIAARDPFEQVAGRGAARLADAGIVVEQGLLAAQARELNIGFFSRIERGRPWTRATLGLPIDAPPALDSAELAALDAALSEARDDLRHWRARSSLVLERAPDAGRAVGCNAAAPRYVVSARDCAALGAASAACAPADGVPTLALHRDDNSASACEDAHGIGHRARRVDRVDHADARPAGAPSASASDTDAGLPLPDAFARLARQGVNELLVDADLALCDALFGSDLADELLLYAHPARRDAPVSASRLAAAIDDVARRWGLRPLERLAIGRGERILLRRARGPEPRQGEPGVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LA6</accession>
    <name>Q63LA6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111115.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1102"/>
    <dbReference type="EnsemblBacteria" id="CAH38570">
        <property type="protein sequence ID" value="CAH38570"/>
        <property type="gene ID" value="BPSS1102"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1102"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5247"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMAYEVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="269" mass="29519" checksum="ED3FF814ECC607DD" modified="2004-10-25" version="1">MSRYTLGHSPIELRRLDFQSEMLKPVTRRLLESARLRPSMRVLDIGCGTGGVSMLAAEMVGPAGTVVAIDPSEVAIEAARANAERARLHNIRFRACGLDQVEGAHGFDVVVFRCVVIHQLHAVEFVRHAARFVKPGGYLALHEPDFVRKPMSTPAIPLWDSVTAEILERCKRSFPSFDVAHRMVKLFAAAGLPLPKMAYEVPVDGGTATKLSSWLAEMLRALSSDPDSTVLGNGKRIEFGRLSGDLQCEIHEARAQVEFFGQLCACAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LB7</accession>
    <name>Q63LB7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HNS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524142.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111104.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1091"/>
    <dbReference type="EnsemblBacteria" id="CAH38559">
        <property type="protein sequence ID" value="CAH38559"/>
        <property type="gene ID" value="BPSS1091"/>
    </dbReference>
    <dbReference type="GeneID" id="56530495"/>
    <dbReference type="KEGG" id="bps:BPSS1091"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4293"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRPKWLQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="5">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="109" mass="12306" checksum="3952F6FDFBB13F78" modified="2004-10-25" version="1">MTSSKIQTLQKELGHLNLLLEEAKKKEKAEALAAIREQVKQFDITEVELLRAAGFVKDKPKKLPAKYYDPSTGKSWTGRGACPKWLIGKNLDDYLIRPAPEPWWPGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LF1</accession>
    <name>Q63LF1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage gp31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205521.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111070.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1059"/>
    <dbReference type="EnsemblBacteria" id="CAH38525">
        <property type="protein sequence ID" value="CAH38525"/>
        <property type="gene ID" value="BPSS1059"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1059"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5194"/>
    <dbReference type="eggNOG" id="ENOG503296Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDWLTLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021815">
        <property type="entry name" value="DUF3396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11876">
        <property type="entry name" value="DUF3396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="373" mass="40839" checksum="617A20EF4427C048" modified="2004-10-25" version="1">MAMTQDELAAWANDPGRAGSLPYGLFEPNHQRKIVGAILAVRGVLYFRDGHTPQRREALTRCFQRYDAALRTYQHALAQSQGREPSKGTPLRWLYQEGKQPTAIEKAPSFSSLAKDTPSDDLLVVGLSDAEEKEGAGAMEFVTFCLEDWQAALNRGLDVLSFSVPPAFLTLCPNVFQALFAQAADDLDAVHGHAGYAVNLSLLRRDPNEASEYFLARRYGPGLDVGDPVRRGVRRLTNRIKTVDWLTAINADMVRELGGRQSLALPPDWFGLRSYGNDGLLIQAGVAPQTGIAGEKGQAPEPPPAYVLVNQALRPLIADAVGTLQSGTPNSTAPLLNTEVSTEAWLHRFDIDPGRIYGYWEALHKMPKLPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LG2</accession>
    <name>Q63LG2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS1048d</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532784.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111059.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1048d"/>
    <dbReference type="EnsemblBacteria" id="CAH38514">
        <property type="protein sequence ID" value="CAH38514"/>
        <property type="gene ID" value="BPSS1048d"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1048d"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4244"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="45" mass="5112" checksum="7080398E244D8F7B" modified="2004-10-25" version="1">MKRKEKTLPLWAIWLISLVAVIAWCGVHGEPEQPVQQEIRPVSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LH8</accession>
    <name>Q63LH8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205514.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111043.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1037"/>
    <dbReference type="EnsemblBacteria" id="CAH38498">
        <property type="protein sequence ID" value="CAH38498"/>
        <property type="gene ID" value="BPSS1037"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1037"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4222"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYSVFMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="37"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="489" mass="51848" checksum="57593BFC7D464D16" modified="2004-10-25" version="1">MSTLDLDAPISTPIRTASDVSRLINASGARANHARVIVLLALGGVFLDAYDLTTLSYGIEDVTREFGLTPALSGLVSASIMIGTILGSLLGGWFTDKVGRYRVFMADMLCFVVAAIVAGLAPNVGVLIAARFVMGLGVGIDLPVAMAFLAEFSKFGGRGNKASRLAAWCPMWYAASSVCFLIVFGLYFALPAEHARWLWRASLIFGAVPALAIIAVRGRYMNESPLWAANQGKLRDAARILRESYGIRAHAADDTPRAAPSQPPVSFRVLFRQPYLPRTLVASAMNLCIPFEYTAIAFFLPTILTQFLGAGVFETIAATLALNVLFALTGGLLGMRLAYRLPSRRVAIAGFALQAAALVTLALLGHPQTALGIGAAVLMLGLWLFAEGFGPGAQMMIYPALSYPASIRGTGLGFGRALTGIGSAFALFVLPILNARLGAGMFWIVAIAAFVPIVFLAAIRFEPTARDVDVDIDAGSRAQGDRARVRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LH9</accession>
    <name>Q63LH9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539126.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111042.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1036"/>
    <dbReference type="EnsemblBacteria" id="CAH38497">
        <property type="protein sequence ID" value="CAH38497"/>
        <property type="gene ID" value="BPSS1036"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1036"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4221"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SDDWDGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="3">
        <location>
            <begin position="137"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="5">
        <location>
            <begin position="245"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="419" mass="44934" checksum="47E8B6BA20AAEDFC" modified="2004-10-25" version="1">MSHAPADPTRSTGADYASLAARFRPIFARIAEGAIERDRTRALPHEPIRWLKEAGFGALRVPVHAGGAGASVPQLVQLLIELAAADSNLPQALRGHFAFVEDWLNAPPDAARRAWFDRFASGQLVGNAWTEVGDVALGEVRTKVAKRDGGWVVNGEKYYSTGAIFADWIDVYAQRTDDGGPVIAAVAARQDGVILGDDWDGFGQATTGSGTTRFVDARVDEANVIDFARRFKYQTAFYQLFHLATLAGIGRAVERDASALVRGRRRVYSHGNAPRVSDDAQILQVVGEISAWAYAAEAIALRAAQPSQRAYEARGGGDAAAEHDANVAAEIESAQGQLVVSELVLRAATHLFDALGASATRATNALDRHWRNARTVASHNPLVYKARIVGDRAVNGTEPPYVWQIGAGPGGPREPEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LK8</accession>
    <name>Q63LK8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111013.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1007"/>
    <dbReference type="EnsemblBacteria" id="CAH38468">
        <property type="protein sequence ID" value="CAH38468"/>
        <property type="gene ID" value="BPSS1007"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1007"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5134"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWIKGIN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="178"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="346"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="540"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="719"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3073"/>
            <end position="3150"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3197"/>
            <end position="3274"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4923"/>
            <end position="5000"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LM2</accession>
    <name>Q63LM2_BURPS</name>
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        <recommendedName>
            <fullName evidence="2 11">Catalase</fullName>
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            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
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            <name>heme</name>
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    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
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            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <position position="72"/>
        </location>
    </feature>
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        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAH38454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="505" mass="54998" checksum="E6FAC15AF52DA453" modified="2004-10-25" version="1">MRWLSRALVAVSASGALAAHASTLTRDNGAPVGDNQNSQTAGANGPVLLQDGHLIQKLQRFDRERIPERVVHARGTGAHGVFVATRDISDLTRAKVFEPGTQTPVFVRFSSVIHGGTSPETLRDPRGFATKFYTAEGNWDLVGNNLPVFFIRDAMKFPDMVHSLKPAPDTNIQDPDRFFDFFSHQPEATHMITRVYSDAGTPASYREMDGNSVHAYKFVNAHGGVTYVKFHWKSLQGQKNLTAAQAEAIQGKDFNHMTRDLIAAIDAGRYPKWDLYVQTLKPDQLDQFAFDPLDATKVWPGVPEVKIGTMTLNRNPGNVFQETEQAAFAPSNLVPGIEPSEDRLLQGRLFAYADTQLHRVGVNGAQLPVNRPRAPVANYNRDGAMNGGAARGTVNYEPGAQAALAADPAFAASRAPLAGSTQQARIAKTRNFDQAGAFYRSLSASERANLVANLAGDLKQVRNDGVKYTMLSYFQKADAEYGRKVTAALGADQGRVDALTAKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M25</accession>
    <name>Q63M25_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184839.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110846.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0835"/>
    <dbReference type="EnsemblBacteria" id="CAH38297">
        <property type="protein sequence ID" value="CAH38297"/>
        <property type="gene ID" value="BPSS0835"/>
    </dbReference>
    <dbReference type="GeneID" id="56597159"/>
    <dbReference type="KEGG" id="bps:BPSS0835"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7111"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DDPMMQL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="23641" checksum="4E4B38BC4E704EF8" modified="2004-10-25" version="1">MIKVLIADDHALVRDGLRHILQNASGYEVAGEAFDSATTIALVRSTPAQVLVLDLSMPGRNGVELIKQIKEEKPALRILVLTMHAEQQYAVRAFRAGASGYLTKESASSELVGAVTKVASGGVYVSLAMAERFAQSLNEPAETLPHHRLSDREFDVFRRIASGQTLTQIADELCVSAKTVSTYKTRILEKMQMPHEAALVRYALRHKLIDDPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M27</accession>
    <name>Q63M27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200933.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110844.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0833"/>
    <dbReference type="EnsemblBacteria" id="CAH38295">
        <property type="protein sequence ID" value="CAH38295"/>
        <property type="gene ID" value="BPSS0833"/>
    </dbReference>
    <dbReference type="GeneID" id="56597157"/>
    <dbReference type="KEGG" id="bps:BPSS0833"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4923"/>
    <dbReference type="eggNOG" id="ENOG50343ST">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PEPPEYC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009962">
        <property type="entry name" value="DUF1488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036692">
        <property type="entry name" value="Shew3726-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07369">
        <property type="entry name" value="DUF1488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160272">
        <property type="entry name" value="SSF160272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10739" checksum="66E567C0A66FD009" modified="2004-10-25" version="1">MSVMKISFPQDPPPEYCARDLVVAFPALVDGEYVQCAITAEALEDHFGAASLKEDDLLTAFDLHRGKIEHAARRMLDEIGGKPVLLHSGFFRFLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M98</accession>
    <name>Q63M98_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195012.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110773.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0762"/>
    <dbReference type="EnsemblBacteria" id="CAH38222">
        <property type="protein sequence ID" value="CAH38222"/>
        <property type="gene ID" value="BPSS0762"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0762"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7004"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQCGPLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="445" mass="46974" checksum="5D146FFA93789387" modified="2004-10-25" version="1">MSTPHAEAFCAPAGSARASLNRLLFRKLMPILITAYVISFLDRTNIAFAKHSMGIDLGLSSAAYGLGAGLFFVTYALFEIPSNLIMHRVGARFWIARIMITWGALSVAMALVRGETSFYAMRLLLGAAEAGLFPGVMLYLTYWFGHEERARATGYFLLGVCVANIVGGPLAGALLALDGALGLHGWQWLFIVEGVPAIALAFVVWARLPERPSDARWLAPELGRALERALASEQAQSAAAHGAQAFGVALRDPQIWLAIFVYFCHQLTIYTMIFFLPGIIGESGRFSPIVVGLLAAMPWLAAALGAATLPRFARDSSRSRRILCAGLGVMAAGLVCAAYAPPAAALASVCVAASMFFVVQSIVFTFPASRLAGSALAGGLGLVNTCGLLGGFVGPTVVGTIEQTTGHAKNGLALLAIALGVAALASLRLRHGHERAHPARPSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ME4</accession>
    <name>Q63ME4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551490.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110727.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0713"/>
    <dbReference type="EnsemblBacteria" id="CAH38173">
        <property type="protein sequence ID" value="CAH38173"/>
        <property type="gene ID" value="BPSS0713"/>
    </dbReference>
    <dbReference type="GeneID" id="56530837"/>
    <dbReference type="KEGG" id="bps:BPSS0713"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6934"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CRGTFRN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="195"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="411" mass="46443" checksum="307342CA5C289044" modified="2004-10-25" version="1">MTKNEESARGLASELARGFTDVRRHSVELARPLSAEDQALQSMPDASPTKWHLAHTTWFFETVILARHARGYRLFDSRYPYLFNSYYEALGPRHARPQRGMLSRPSQDDVRRYRRHVDDALLELLRTADLPTLIAIEPEITLGLHHEQQHQELILTDILHAFSLNPLLPAYRSDDAAPTADARRANGAMRWLPGPIGVVEIGHDGRGFSFDNERPRHRTMLHPYEIAERLVTNGEYAAFIDDGGYARPEFWLSDGWAIVQREGWKAPLYWIASDGGEGLGWREFGLGGLQPLTRDAPVSHVSFYEAAAYAEWARARLPTEAEWEAAFDAPGIAQMTGCVWQWTRSSYEPYPGFRPMAGVAAEYNGKFMVGQQVLRGGSVATPPGHARATYRNFFPPAARWQFTGVRLARDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MG0</accession>
    <name>Q63MG0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ureidoglycolatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Ureidoglycolate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hpcG</name>
        <name evidence="9" type="ordered locus">BPSS0697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194587.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110711.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0697"/>
    <dbReference type="EnsemblBacteria" id="CAH38157">
        <property type="protein sequence ID" value="CAH38157"/>
        <property type="gene ID" value="BPSS0697"/>
    </dbReference>
    <dbReference type="GeneID" id="56597619"/>
    <dbReference type="KEGG" id="bps:BPSS0697"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6911"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IQRAWVA"/>
    <dbReference type="UniPathway" id="UPA00394"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018817">
        <property type="term" value="F:2-oxo-hept-3-ene-1,7-dioate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012690">
        <property type="entry name" value="HpcG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02312">
        <property type="entry name" value="HpaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="78"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="267" mass="29303" checksum="550F30107F849E21" modified="2004-10-25" version="1">MLDSATIQLLARRLHVAERERRQIRQISLDYPEITIDDAYAIQRTWVDMKLAEGRVLKGHKIGLTSKAMQSSSQIDEPDFGALLDDMFFEDGATIPTRRFIVPRVEVELAFVLGKPLKGPDCTVFDVYDAVDYVVPALEIIDARSQSIDPDTKRPRKVFDTIADNAANAGVVLGGRPVRPMDVDLRWVAAIMSRNGVVEETGVAAGVLNHPANGVAWLANRLARFDVSLDAGEIILGGSFTRPCAAKSGDTFNVDYGPLGAIHCHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MK6</accession>
    <name>Q63MK6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523737.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110665.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0646"/>
    <dbReference type="EnsemblBacteria" id="CAH38103">
        <property type="protein sequence ID" value="CAH38103"/>
        <property type="gene ID" value="BPSS0646"/>
    </dbReference>
    <dbReference type="GeneID" id="56530903"/>
    <dbReference type="KEGG" id="bps:BPSS0646"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6841"/>
    <dbReference type="eggNOG" id="ENOG5033BAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FNACLGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016410">
        <property type="entry name" value="Phage_imm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14373">
        <property type="entry name" value="Imm_superinfect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="12379" checksum="8B7B8C58B4DD0067" modified="2004-10-25" version="1">MQMEILIQIVGSVVAIALYFLPAIVADRRHRDDKLTIALFNALFGWTGIGWLLTLYWSLQPNATDDFVSDVRLKRRALSMKTFSTGLVERVQRRIAAQEQWADKQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MU5</accession>
    <name>Q63MU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative electron transfer flavoprotein beta-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535153.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110574.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0553"/>
    <dbReference type="EnsemblBacteria" id="CAH38010">
        <property type="protein sequence ID" value="CAH38010"/>
        <property type="gene ID" value="BPSS0553"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0553"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6721"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVEERPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="27582" checksum="40FF2F5B05E00197" modified="2004-10-25" version="1">MNANRKLASIAVLVSVGRHSVSGVPRYSRNDAAALEIGRALAAEHRARLDVIHAGDARNPALADYLALGAASVEVLACADGDDAAAALAERVRGHDLVLTGTRAEGAYDTGMLPYRVAAALGWPFVGAAVDVSVDAARATLRQFLPKGVRRRVDAALPAVVAVHPLANAQPRYAYARLRAGEVRVTRAATRAAADAGQWTTRAVERKPVRLAAADKRSGHARMLSATTTESRGGNVVIEGSSVEKAQVILAYLREHQLIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MV5</accession>
    <name>Q63MV5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative levansucrase</fullName>
            <ecNumber evidence="4">2.4.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.10" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546670.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110564.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0543"/>
    <dbReference type="EnsemblBacteria" id="CAH38000">
        <property type="protein sequence ID" value="CAH38000"/>
        <property type="gene ID" value="BPSS0543"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0543"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6710"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPWFFED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050053">
        <property type="term" value="F:levansucrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009758">
        <property type="term" value="P:carbohydrate utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08997">
        <property type="entry name" value="GH68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003469">
        <property type="entry name" value="Glyco_hydro_68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02435">
        <property type="entry name" value="Glyco_hydro_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266602" evidence="3">
        <location>
            <begin position="33"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="521" mass="56326" checksum="292D49B2885E4FE7" modified="2004-10-25" version="1">MTYSKQAVSRRHKRLALSAAALTAAACMSAHAQSDGAGPAPTPHTQQAYDPESHFTMRWTRADMRQIVKQSHTAGADKNSLPPALTMPDIAQNFPLVDSNVWVWDTWPLADMRANQLSYKGWEVIFSLSADPRAGYTFDDRHVHARIGFFYRRAGIPASQRPANGGWTWGGHLFPDGASAKVFGTAPMTNNAEWSGSARLTHGENVSLYYTALSFNRSAPGGADITPPIAIITRADGHIHADDKHVWFSGFDDHKALLQPEGKMYQTGQQNTYYSFRDPFVFTDPAHPGNTYMVFEGNTGGPRGARTCTEADLGYAPNDPYREDLNAVMNLGAVYQKANVGLAIATNPQLTEWKFLPPLLSANCVDDQTERPQIYLKDGKYYLFTISHRTTMAAGIDGPDGVYGFVGNGIRSDFLPLNGGSGLVLGNPTDFSAPAGAPYAQDPNQNPRAFQSYSHYVMPGGRVESFIDAIGARRGGTLAPTVKIDIHGDSTTVDRAYGAGGLGGYGDIPANLPAVGAGHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N92</accession>
    <name>Q63N92_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative methylamine utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110427.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0404"/>
    <dbReference type="EnsemblBacteria" id="CAH37859">
        <property type="protein sequence ID" value="CAH37859"/>
        <property type="gene ID" value="BPSS0404"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0404"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4396"/>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHTLSET"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267007" evidence="5">
        <location>
            <begin position="31"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="74"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="258"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="456" mass="49388" checksum="7B6C38AD0DC88DBF" modified="2004-10-25" version="1">MSRAGRARRVTALALALAALAGAASLAVRAAPASTTMLLPGAPPARVVDTIGNGTPQVSSKIDASAARFVPDPTLVALGRRIFFDTRLSEPRGMSCAGCHDPGRAFAPTLSAAALAGPGVPEGSRPGRFSRRNAPSLLYVRYVPRRHFYQDDDAPAPSPFGGLFSDGRADTLAEQIRGPLFDPNEMNNRSPAALLRKVDATELAPALAARFGDGVRLDPAQLVRALGASVEAYLQSDEMAPFTSRFDAYLRQRTPLDAQQMRGLALFKNPDKGNCMSCHTLSDTSSRPKRSLFTDFGYDAIAVPRNRALPANRDPRHFDNGLCDTARRLRWPEPGQWCGYLRTPSLRNVALKQTFMHNGVFTSLRDAVAFYNTRSTDPRHWYHGAATFDDVPPAYRGNINVNSTPMNRRPGTPPALTEAEIDDLVAFLGTLTDARYAAGVPPHLKIHDSQAFTIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NI3</accession>
    <name>Q63NI3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ACB transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188666.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110336.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0316"/>
    <dbReference type="EnsemblBacteria" id="CAH37764">
        <property type="protein sequence ID" value="CAH37764"/>
        <property type="gene ID" value="BPSS0316"/>
    </dbReference>
    <dbReference type="GeneID" id="56597794"/>
    <dbReference type="KEGG" id="bps:BPSS0316"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6429"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGGTVWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="22792" checksum="D5F7F741CF5AC45F" modified="2004-10-25" version="1">MSELWLPELADAIRDTLWMVGASALVAALVGVPLALVLVTTAPGGLYERRGVNAALGAIVNAFRSTPFVILLVALLPFTRFVIGTTIGVWAAIVPLSIAAIPFFARIAEVSLREVDKGLVEAAQAMGAERRHIVLHVLLPEALPGIVGGFTITVVALIGSTAMAGAVGAGGLGDLAIRYGYQRFDTAVMATVIAILIALVTVVQFTGDRVVRRLAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NL3</accession>
    <name>Q63NL3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004557414.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110306.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0286"/>
    <dbReference type="EnsemblBacteria" id="CAH37734">
        <property type="protein sequence ID" value="CAH37734"/>
        <property type="gene ID" value="BPSS0286"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0286"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6385"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYIAWLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="145"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="277" mass="29352" checksum="5EEB0EDC27CD6573" modified="2004-10-25" version="1">MEHRFVLLVLLCALLHAVWNALLHASEDRVAQLGTMSVPYLLAGAAGALALPPPPAPAWPYVAASALLELGYCAALLRAYRSGDFSRIYPIARGLSPLTVCALALIALGERPTPFALAGIALVSLGIASLALRRGLRWSGESVPYALVTGLFIAAYSVVDGRGVRLAGDPLAYVAWVYLLWNAPQFALICRLRGWRALARSRAAVSRGLAAGVLSLAAYAIAIAAYRHLPVATVSALRETSSIFAIAIGWFALRERPSARRLAACALVVAGAMLIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NL7</accession>
    <name>Q63NL7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529826.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110302.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0282"/>
    <dbReference type="EnsemblBacteria" id="CAH37729">
        <property type="protein sequence ID" value="CAH37729"/>
        <property type="gene ID" value="BPSS0282"/>
    </dbReference>
    <dbReference type="GeneID" id="56531261"/>
    <dbReference type="KEGG" id="bps:BPSS0282"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6379"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEEPSYW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="564" mass="59797" checksum="8B506790E912A84A" modified="2004-10-25" version="1">MRVSVLSDWLAQRIVRGGGAQPIYRQLHRLLQQAILTRELPAGARVPSSRLLAAELGIARNTVTQVYEQLALEGYVSSATGRGTFVADSAPDEIVGAPADSPPGLPRPGLPGTRGAAAGAEAAAGIGFDPTLEPGAARRSLSARGARLVGGAGVSKRQGGAFMPGVPDVSRFPARVWTRLHNKYWRRLRPELLTYAPGGGLAPLREALADYLRTSRSVRCAPEQIIVTTGIHQSIDLAVRLLTDPGDVIWTEDPCYWGVRSVMHVSGLTTRPIPVDEEGIAPAAADFAAPPKLMLVTPSHQYPLGMVMSLARRRMLLEYARQHGAWIIEDDYDSEFRYGSRPLASLQGLDTAGQVIYVGSFSKTLFPGLRVGYLVAPEPLAESFATASAELYREGQLLQQAVLAEFIAEGHFVSHIRKMRTLYGQRRQTLLDALARRYGDALPAVGGDAGLHLVMRLPDGADDRALARAALERDIVVRALSGYYAQATRAASGLLLGYACVPEDEIGCAFDALSRAIDDVAFGRAAAASSAPASTSAAAASSASSASAASTTSAAARMPAAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NT2</accession>
    <name>Q63NT2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110237.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0217"/>
    <dbReference type="EnsemblBacteria" id="CAH37662">
        <property type="protein sequence ID" value="CAH37662"/>
        <property type="gene ID" value="BPSS0217"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0217"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4168"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIEIGYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="30324" checksum="3792092225F10C70" modified="2004-10-25" version="1">MRHVRAFLCVARHLHFARAADELDIAPPALTRLVQDAERLLGVRLFHRTRRSVALSAAGAAYLGEAQAALAHLARGRERAALAERGEIGRIELGYVSSAAYAGVLQRTVGAFRDAHPRIRVDVREVPMSEVAARLDAGTLDAAYVRPPLPLPDGVSTHTVHRDVFVVAVHGQSPLAARASIRPAALAGERFVVPEQALGTLEAARRGRFEPIVDARPGALVAVLAHVSVSGGVAIVPKALVGCVSLPGVAYRPIEGKPIASEVAVAYRRHEKAPAVRAFVRQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NV8</accession>
    <name>Q63NV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529738.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110211.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0191"/>
    <dbReference type="EnsemblBacteria" id="CAH37636">
        <property type="protein sequence ID" value="CAH37636"/>
        <property type="gene ID" value="BPSS0191"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0191"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6256"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FSHIAFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="14550" checksum="EF69E4F4D15956F9" modified="2004-10-25" version="1">MSVIGLDHYNLRAPRPLLDTLRDFYIDVVGLRLGARPPFRSHGYWLYAGAQAVLHLSQAGPDETRRANVVNTFDHVAFPCDDLPGTLARLQRFGIRYSSADVPLTRQHQLFFDDPAGNGVELNFAVRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P68</accession>
    <name>Q63P68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110101.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0078"/>
    <dbReference type="EnsemblBacteria" id="CAH37523">
        <property type="protein sequence ID" value="CAH37523"/>
        <property type="gene ID" value="BPSS0078"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0078"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3995"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPQIHSP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028244">
        <property type="entry name" value="T6SS_Rhs_Vgr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018769">
        <property type="entry name" value="VgrG2_C_DUF2345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10106">
        <property type="entry name" value="DUF2345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13296">
        <property type="entry name" value="T6SS_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="2">
        <location>
            <begin position="491"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS_Vgr" evidence="4">
        <location>
            <begin position="561"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2345" evidence="3">
        <location>
            <begin position="700"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="923" mass="98832" checksum="95C6D3ABEA31D7B5" modified="2004-10-25" version="1">MNDTLRNFASGAVDWNKRPVALHFGAAQAALGHLLALQHASVQEGLMTGIHGRLTCVSTRRDLPPGVLLGIPVSIRLITDRGQPHTVNAIISDVQIGQSDGELCVYQLTVCDALSLMDKRTNSRVFRKRSVIDVLATLFNEWQQRSPALARAFEFDLSGLRADRYPPRELTRQVNESDAHFVRRLLRREGITVFAKAGPAKGERPLQGDAPVHTLVCCDDPMSLPQAPAGTVRLHPRDGGAAQRDTVTLFALRRQLAPGKAGRPSWDYKKARIDESSVASSLDQGEAGNDLAKLLTDIAIDIAHAGDSWRDHERLTRARMLAHEFEAERHDGVSSVRDLAVGTWITLTGDPQWDRQRADKRQFVITSIDHDIWNNLPKGLNERVHALFAASRNLAYAPRALPSALANDADTRYENTFACVRRGVPLAPAYDPQADLPPAHLLTGTIVGAEGEEVFCDEDGRVRVRVHGLDPADHAHAQGAGTNGNAGDSAPIRVASSLAGAHFGASFLPRVGMEVLLGCLGGDPDRLVIIGVLGNGAHPPATFSHAGGLPGNRYLSGIKTKEIRGQRYNQLRLDDTPNQISAQLASEHAHSQLNLGYLTQPRENGHGNDRGEGVELRTDAAAALRAAQGMLLTTYARTQASGGQLDRDELIRLLGECAELFKALGDYAGQHGGQAADTAGQHAVAAAFKRWAPGTDGADAPSDGAARALMAFGAQAGSVNVTPKTHVTYAGENIDQVAQQHLQLMSGQRLNATAGQGMQLFARGAGVQAVAGEGPMLLQAQAGTLTANAQKGVKITTNEHEVFVSAPKIRLVAEDGSYLELGGGITLGTNGDIKLLSASHQWGGPSTAQAAKSGFGNQPTDQRFKLHYPGEDGDLQAAANKRFRITLDDGRVIEGKTDASGLTDLVKDDAMRIAKIDYLKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PL6</accession>
    <name>Q63PL6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109953.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3358"/>
    <dbReference type="EnsemblBacteria" id="CAH37371">
        <property type="protein sequence ID" value="CAH37371"/>
        <property type="gene ID" value="BPSL3358"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3358"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3814"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFERWRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="3">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="4">
        <location>
            <begin position="152"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="367" mass="39583" checksum="41380D78E6C1F3EA" modified="2004-10-25" version="1">MRRPSRSAPFRKQTGSFMSSTLKIGLMGFGFAGATFHAPVITHSGRTRLAAIATGQPERAAAAYPEAAVVPDLDALAARDDVECVVIATPNDTHVDLAKRALEAGKHVVVDKPVALSAADALGLARLAAARGRVFAPFHNRRWDGDFLTVRHLVESGELGRIVCFESHFDRFRPHVRTRWREEAARGGGLLFDLGPHLIDQALALFGPPETVSATVKTRRDGGDAPDFVHLQLGYPDKDVVLHASALAAIEPARFTVLGTQGGYQKHGLDTQEDQLKAGLTPDDVEFGGGNPPGVLRGLDGELEVERPVPTLDGQYAEFYRALAASIHDGAPFPVAPQDAVDVMTIIETAMRSEREGRRLPFVREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QF7</accession>
    <name>Q63QF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539238.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109661.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3066"/>
    <dbReference type="EnsemblBacteria" id="CAH37077">
        <property type="protein sequence ID" value="CAH37077"/>
        <property type="gene ID" value="BPSL3066"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3066"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2193"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDCFRSQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="39"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="326" mass="34522" checksum="7F13F7A327527E5B" modified="2004-10-25" version="1">MNQLIDTLGRRAVLIGVALGLAACAGGGGPPGEAPATLPRIVAHRGGAADAPENTLDAIRAAVANRADAIWLTVQLSRDGVPVLYRPADLSALTRSSGPVAGHTAAQLAQMNAGWQFRDAGGRYPYRARPVGIPTLRDALRAIPPAMPIVLDMKAVPAAPQAKAVADVLTSEAAWPRVTIYSTDAAYQTAFASYPQARLFESRDATRGRLVDVLLGGACERAPEAPATAPIWTGFEMHRNMTVSERFTLGEGVSPVKATLWTPATVACFRRRADVRILAIAVNDADDYRTAACLGLDAVLADSPREMAEIRSALRARPLRCETGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QQ4</accession>
    <name>Q63QQ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109564.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2970"/>
    <dbReference type="EnsemblBacteria" id="CAH36980">
        <property type="protein sequence ID" value="CAH36980"/>
        <property type="gene ID" value="BPSL2970"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2970"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3395"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGPIPEV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="21146" checksum="4E37D7AF87754E9D" modified="2004-10-25" version="1">MRAFGACPMIAILRGVTPADAAAHGAALYEAGFRIVEVPLNSPDPFDSIAALRTALPADAIVGAGTVLRAGHVDEVVRAGGELIVMPHADGDVVRRAKTLGIGCAPGVATPTEAFAALANGADVLKMFPAEQLGTPAVKAWRAVIDARVPLVPVGGITPENMGPYLAAGASGFGLGSALYAPGQTSAVTAVRAHAFVNGWRIARHGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QR8</accession>
    <name>Q63QR8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="4 11">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL2956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="4 11"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2956"/>
    <dbReference type="EnsemblBacteria" id="CAH36966">
        <property type="protein sequence ID" value="CAH36966"/>
        <property type="gene ID" value="BPSL2956"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2956"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2322"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="246" mass="25868" checksum="8DD14BB4C9507505" modified="2004-10-25" version="1">MPRFFVDAALRADATLALPADVARHAHVLRLQPGDALALFDGTGGQYRARLVEIDKRGALARIDAFEPAEAEPPYRVTLAQGIAGGDKMDWVIEKAVELGVAAVAPLSTARGVVRLSGERADKRVSHWRGVVRASCEQCGRNRLPEIAPVRGFDAWLDALPATPADGELRLLLSPRASVPFASLPAAPPAGDVTLLIGPEGGLAPDEEQAARARGFAALSLGPRVLRTETAGAAVLAALAARWGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QR9</accession>
    <name>Q63QR9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527755.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109549.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2955"/>
    <dbReference type="EnsemblBacteria" id="CAH36965">
        <property type="protein sequence ID" value="CAH36965"/>
        <property type="gene ID" value="BPSL2955"/>
    </dbReference>
    <dbReference type="GeneID" id="56528242"/>
    <dbReference type="KEGG" id="bps:BPSL2955"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2323"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGSTART"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="138" mass="15449" checksum="FD529D4E754442A7" modified="2004-10-25" version="1">MTDPRPADVPWLTPYLTVRSAQASIQFFSDAFGFEKRDLIDEDGAIMHVEMSYRGQLIVMFAPEGAFGSTARTPRSADAIAPQSFYLYVDDVDATYRRALDAGAKSLSAPQDQFWGDRFAQIEDLDGYRWALARRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV0</accession>
    <name>Q63QV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate/aspartate periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gltI</name>
        <name evidence="4" type="ordered locus">BPSL2924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109518.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2924"/>
    <dbReference type="EnsemblBacteria" id="CAH36934">
        <property type="protein sequence ID" value="CAH36934"/>
        <property type="gene ID" value="BPSL2924"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2924"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3340"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TANCARW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266255" evidence="2">
        <location>
            <begin position="26"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="39"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="33053" checksum="68710170BC7C56B3" modified="2004-10-25" version="1">MTTMKFPKAMLMVAALSTFAGGAIAQETGTLKKIKDTGVIALGHRESSIPFSYYDQNQQVVGYSRDFQMKVVDAVKKKLNLPNLQVKNIPVTSQNRIPLVQNGTVDIECGSTTNNLDRQKQAAFSDTIFVIGTRLMTKKDSGIKDFADLKGKTVVTTAGTTSERLLREMNNKNQMGMSIISAKDHGESFQTLETGRAVAFMMDDALLAGERAKAKQPGEWVIVGKPQSQEAYGCMMRKDDPAFKKVVDDAIVQVEKSGEAAKIYSKWFENPIPPKGLNLNFPLSDEMKKLYANPNDKALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV2</accession>
    <name>Q63QV2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate/aspartate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltK</name>
        <name evidence="9" type="ordered locus">BPSL2922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194080.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109516.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2922"/>
    <dbReference type="EnsemblBacteria" id="CAH36932">
        <property type="protein sequence ID" value="CAH36932"/>
        <property type="gene ID" value="BPSL2922"/>
    </dbReference>
    <dbReference type="GeneID" id="56593759"/>
    <dbReference type="KEGG" id="bps:BPSL2922"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2361"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQSMKLV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030205">
        <property type="entry name" value="GltK/AatM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614:SF1">
        <property type="entry name" value="PTHR30614:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="225" mass="24536" checksum="606435AA9F2291D8" modified="2004-10-25" version="1">MHQFDWSSIPGALPTLWTGAVVTFKITLLAIVIGIVWGTLLALMRLSGVKPLAWFAQGYVTVFRSIPLVMVLLWFFLIVPQLLQGVLGLSPTIDIRLASAMVAFSLFEAAYYSEIIRAGIQAVPRGQVNAAFALGMNYAQAMRLVILPQAFRAMVPLLLTQAIVLFQDTSLVYVISLADFFRTAANIGDRDGTSVEMILFAGACYFVVCSVASALVKGLQKKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R22</accession>
    <name>Q63R22_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phosphonates transport ATP-binding protein PhnL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phnL</name>
        <name evidence="9" type="ordered locus">BPSL2852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522131.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109446.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2852"/>
    <dbReference type="EnsemblBacteria" id="CAH36862">
        <property type="protein sequence ID" value="CAH36862"/>
        <property type="gene ID" value="BPSL2852"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2852"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3253"/>
    <dbReference type="eggNOG" id="COG4778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MHLRDGI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012701">
        <property type="entry name" value="CP_lyase_PhnL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02324">
        <property type="entry name" value="CP_lyasePhnL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="28345" checksum="83691AF04CFAB8F7" modified="2004-10-25" version="1">MQTIESSRRACDHDHARAFAGNAALMLRAVGVGKTFTLHAHGGMTIDALENVSLDVEAGECVALTGPSGAGKSTLLRCLYGNYLANRGTIAVRAGARAAEHVVLTASEPHEVIALRRDVIGYVSQFLRAIPRVPALALVAAPLVARGMPEGDAADRAAHLLARLNVPRRLWTLAPATFSGGEQQRVNIARGLIAEHPVLLLDEPTASLDAENRDVVAELIGDVRRRGAAIVGIFHDEATRERVATRCFPLRPPSRARLPFDEVNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RA8</accession>
    <name>TOLB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tol-Pal system protein TolB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tolB</name>
        <name type="ordered locus">BPSL2764</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533572.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109360.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RA8"/>
    <dbReference type="SMR" id="Q63RA8"/>
    <dbReference type="STRING" id="272560.BPSL2764"/>
    <dbReference type="EnsemblBacteria" id="CAH36772">
        <property type="protein sequence ID" value="CAH36772"/>
        <property type="gene ID" value="BPSL2764"/>
    </dbReference>
    <dbReference type="GeneID" id="56528433"/>
    <dbReference type="KEGG" id="bps:BPSL2764"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2551"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VREPSWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00671">
        <property type="entry name" value="TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014167">
        <property type="entry name" value="Tol-Pal_TolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007195">
        <property type="entry name" value="TolB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04052">
        <property type="entry name" value="TolB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02800">
        <property type="entry name" value="propeller_TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000034633" description="Tol-Pal system protein TolB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00671"/>
        </source>
    </evidence>
    <sequence length="433" mass="45894" checksum="6F4943F6E061F064" modified="2004-10-25" version="1" precursor="true">MSLMTKLGFRALVASCLIAAGGAAHAQVNVLITGVGSTQFPIATANFVNEASLPQQVTSVVRGDLARSGKFSNVDAGSTPVPETASVDFGAWKAKGANAFVAGSVNREPNGQYKVNFILYDTVKQQSLGGLSLTTSNDNEGMRKTGHKIADYIYQKLLGVRGVFNTRLSYVQRTGNVYKLLISDSDGQNAIPALTSKEPIISPAWSPSGTKVAYVSFELRKPVVYIHDLPTGRRYVISNQKGNNSAPAWSPDGQTLAVALSLTGNTQIYSVSSTGTGLRRLTRSSSIDTEPFYSPDGKWIYFTSDRGGAPQIYRMPAEGESAGAAQRVTFTGSYNTSPRVSPDGKLLAYISRTGGGFKLYVQDLQSGAANAVTNTTRDESPSFAANGQYILYATQSGGRSVLAAVPSDGSAPPQILSVQGGAIREPSWGPFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RE6</accession>
    <name>Q63RE6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative solute-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527624.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109322.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2726"/>
    <dbReference type="EnsemblBacteria" id="CAH36734">
        <property type="protein sequence ID" value="CAH36734"/>
        <property type="gene ID" value="BPSL2726"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2726"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2601"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLHVMSS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266722" evidence="1">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="26855" checksum="3E6514094F48C86D" modified="2004-10-25" version="1">MRHLLTKPVGAALLAAAAALAQAHAAELHVMNSGGFTAAYQLLAPKFEAATGNTLDIAYGPSMGATPEAIPNRLARGEPADVVIMVGYALDKLIREGKVEPGSRVELADSRIGAVVRAGEPAPDIGTPAALKAALLQAKTVAYSDSASGVYVQNELFKRLGVEAEVKPKATMVPRVPVASKVADGTYALGFQQVSELLPVPGVTFVGKLPEPLQSVTRFAGGIPVGAKHPREARALLDYLASPAAAGDVRKTGLDPVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RK0</accession>
    <name>Q63RK0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative epimerase/dehydratase polysaccharide-related biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wbiI</name>
        <name evidence="4" type="ordered locus">BPSL2672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185930.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109268.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2672"/>
    <dbReference type="EnsemblBacteria" id="CAH36680">
        <property type="protein sequence ID" value="CAH36680"/>
        <property type="gene ID" value="BPSL2672"/>
    </dbReference>
    <dbReference type="GeneID" id="56595008"/>
    <dbReference type="KEGG" id="bps:BPSL2672"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2670"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="288"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="637" mass="69909" checksum="364F2BA9AB870D8D" modified="2004-10-25" version="1">MTRAFCPKASWLSLGAFLFDLMAVVCAWLIAYVVRFNGAMPPEFLKGAFVALAWVVPLYGLLFHVFGLYRGLWVFASLPDLLRISKAVVGGGLIVMIGAVMLQPVPIIPRSVLVLSPMLLFLAMGGARALYRATKEFYLYGGLIGQGKPVLILGAGSAGASLARELSRSGEWRLAGLLDDDPAKHGREVYGYKVLGSIGEVADWAEAAKAEYAIIAIPSASVEAQRRFATLCVRAGVRAMVLPSLTALMPGQGILSQIRQIDLEDLLGREAVTIDTPHVEALLRGRVVMVTGAGGSIGSELCRQILKFQPAQLIAFDLSEYAMYRLTEELRERFPDLPVVPIIGDAKDSLLLDQVMSRYAPHIVFHAAAYKHVPLMEELNAWQALRNNVLGTYRVARAAIRHDVRHFVLISTDKAVNPTNVMGASKRLAEMACQALQQTSARTQFETVRFGNVLGSAGSVIPKFQQQIAKGGPVTVTHPEITRFFMTIPEASQLVLQASSMGQGGEIFILDMGEPVKIVDLARDLIRLYGFTEEQIRIEFSGLRPGEKLYEELLADDETTTRTPHPKLRTAKAREVPDHLLDELLPWLMQHRVLSDDEVRRDLRRWVPEYQPAVGPTLQSVPTGNGLVAGIGREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RN5</accession>
    <name>Q63RN5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554203.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109233.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2637"/>
    <dbReference type="EnsemblBacteria" id="CAH36645">
        <property type="protein sequence ID" value="CAH36645"/>
        <property type="gene ID" value="BPSL2637"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2637"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2711"/>
    <dbReference type="eggNOG" id="COG1993">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IEVEFIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="118" mass="13274" checksum="B6AEA244117492DB" modified="2004-10-25" version="1">MDGIFLRFYVHESHRLHWKPLWEWLLEEANRMGIAGGSAFRAMAGFGQHRVLHEDRFFELQGSLAIEVEFVVTEDEAKRLIERVSREKVRACYATIPARLGVIDNLGDGAPGAAPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RP3</accession>
    <name>Q63RP3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109225.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2629"/>
    <dbReference type="EnsemblBacteria" id="CAH36637">
        <property type="protein sequence ID" value="CAH36637"/>
        <property type="gene ID" value="BPSL2629"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2629"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2997"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHMEVGQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="58"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="416" mass="44806" checksum="72015ACFD1166714" modified="2004-10-25" version="1">MRARGARPLFAFLPRFDSTMNTAADSLLRLASRVDAIEPFYVMEIVKEAAVLERAGRDIIHMSIGEPDFTAPEPVVDAAAAALRRGVTQYTSALGIAPLREAIAAHYARAHGLSIAPERIVVTAGASAALLLACLALVGRDDEVLMPDPSYPCNRHFVATAEGRAVLVPSGPETRFQLTADDVKTRWGERTRGVLLASPSNPTGTSLEPAELGRIIDAVRARGGFSIVDEIYQGLSYDGAPVSALSFGDDVVTVNSFSKYFNMTGWRLGWLVVPPALVGTFEKLAQNLFICPSALAQHAALACFEPDTLAIYEARRAEFRRRRDFIVPAIESLGFKVPVMPDGAFYVYAQCGGVAHPAAGDSAALVNAMLHDAGVVLVPGMDFGVHAPRDYIRLSYATAYSRLEEAVERLGKLFGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RP8</accession>
    <name>GSA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="1">GSA</shortName>
            <ecNumber evidence="1">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="1">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemL</name>
        <name type="ordered locus">BPSL2623</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109219.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RP8"/>
    <dbReference type="SMR" id="Q63RP8"/>
    <dbReference type="STRING" id="272560.BPSL2623"/>
    <dbReference type="EnsemblBacteria" id="CAH36631">
        <property type="protein sequence ID" value="CAH36631"/>
        <property type="gene ID" value="BPSL2623"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2623"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2730"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000243555" description="Glutamate-1-semialdehyde 2,1-aminomutase">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <sequence length="427" mass="44798" checksum="58009AB740ACC4D5" modified="2004-10-25" version="1">MSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARAAGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGFVSSAHDDATLDATLDAARRAFAALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX1</accession>
    <name>Q63RX1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109146.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2549"/>
    <dbReference type="EnsemblBacteria" id="CAH36557">
        <property type="protein sequence ID" value="CAH36557"/>
        <property type="gene ID" value="BPSL2549"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2549"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="82" mass="9147" checksum="398ABF692F5154A9" modified="2004-10-25" version="1">MLRDRDERLRREMALAHRRDDVTAQLRRALQRVERAGFRVAADEDAAADRVIGAAARDPLAAHVPTDAAARAPIHAMLARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S37</accession>
    <name>Q63S37_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ordered locus">BPSL2485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109080.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2485"/>
    <dbReference type="EnsemblBacteria" id="CAH36491">
        <property type="protein sequence ID" value="CAH36491"/>
        <property type="gene ID" value="BPSL2485"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2485"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2834"/>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAWRNHA"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031347">
        <property type="entry name" value="AmpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17113">
        <property type="entry name" value="AmpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="329" mass="36316" checksum="AA1F85A38A673B98" modified="2004-10-25" version="1">MLSLREKSIIQNGTALRMTFFSVLLALIIEQVRALSPSNPVFALFQSHAESAAHGFDAGKKKHGVLAWLVVVLPWVLAVGLVYFLLYKVSFVLAFLWNVVVVYFTLGFRQFSHYFTDIHLALNNDDVPRARDILREWTGIDTVDMPVGEIVRHTLIHAVVASHRHVFGVFFWFVLPVGPAGAVLYRIAEYLSRSWSVPADDRTAAFSTFAQRAFFVIDWVPARLTALGFAIVGNFEDAIYAWRNHTRQWPDPNDGVLLAAGSGALGARLAGPLAEPSSVDALASGDSGPLTVGDDCTPRTLQSAVGLVWRAVILWMLLLLMLTIAVWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S74</accession>
    <name>Q63S74_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluC</name>
        <name evidence="5" type="ordered locus">BPSL2451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193798.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109043.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2451"/>
    <dbReference type="EnsemblBacteria" id="CAH36454">
        <property type="protein sequence ID" value="CAH36454"/>
        <property type="gene ID" value="BPSL2451"/>
    </dbReference>
    <dbReference type="GeneID" id="56596366"/>
    <dbReference type="KEGG" id="bps:BPSL2451"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2939"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PKTHVYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="37221" checksum="7D9B6FE7F18F0C89" modified="2004-10-25" version="1">MNELGKKSHNSVASGQVSLIEIDESAAGQRIDNFLLRVCKGVPKSHIYRILRSGEVRVNKGRIDAQYRLAFGDVVRVPPVRVAAADLARAAGPAPVPAAEFEILFEDDAIIVLNKPAGVAVHGGSGVAFGVIEQMRHARPHAKFLELAHRLDRETSGILMLAKKRSALVGLHEQIRENRMDKRYFACVHGDWAADWGRRRVVKAPLFKYATPDGERRVRVQEDGLPSHTVFNLVDRWPDYALVEAELKTGRTHQIRVHLAHLGLPIVGDAKYGDFALNKALARANAVPSIKRMFLHAHRLRLAHPLTGEPLQFDAPLPAECRQFIDQLSDLRDTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S86</accession>
    <name>ACP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name type="ordered locus">BPSL2439</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197638.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109031.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S86"/>
    <dbReference type="SMR" id="Q63S86"/>
    <dbReference type="STRING" id="272560.BPSL2439"/>
    <dbReference type="EnsemblBacteria" id="CAH36442">
        <property type="protein sequence ID" value="CAH36442"/>
        <property type="gene ID" value="BPSL2439"/>
    </dbReference>
    <dbReference type="GeneID" id="60548850"/>
    <dbReference type="GeneID" id="62010505"/>
    <dbReference type="GeneID" id="64461771"/>
    <dbReference type="GeneID" id="67431860"/>
    <dbReference type="KEGG" id="bps:BPSL2439"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2951"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="PRO" id="PR:Q63S86"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180121" description="Acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <sequence length="79" mass="8712" checksum="70727A0B4B69E264" modified="2004-10-25" version="1">MDNIEQRVKKIVAEQLGVAEAEIKNEASFVNDLGADSLDTVELVMALEDEFGMEIPDEEAEKITTVQQAIDYARANVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE7</accession>
    <name>Q63SE7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524657.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108969.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2376"/>
    <dbReference type="EnsemblBacteria" id="CAH36378">
        <property type="protein sequence ID" value="CAH36378"/>
        <property type="gene ID" value="BPSL2376"/>
    </dbReference>
    <dbReference type="GeneID" id="56528811"/>
    <dbReference type="KEGG" id="bps:BPSL2376"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3031"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LRMLMYC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="17863" checksum="E9F4D655D779F964" modified="2004-10-25" version="1">MRLSEYTDYTLRVLMYCASNPDRLITIAELAERHDVSKNHLTKIVNSLARQGTLETTRGRGGGVRLALPPERIGIGDVIRASETDFRLVECFDRNTNTCMLAAKCRLERLLDSALRAYFKELDGATLADLVGAPPKSGLSAAEKTHEFAIAMPPKSIARARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T21</accession>
    <name>Q63T21_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the skp family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108745.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2150"/>
    <dbReference type="EnsemblBacteria" id="CAH36152">
        <property type="protein sequence ID" value="CAH36152"/>
        <property type="gene ID" value="BPSL2150"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2150"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3303"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EKEQYDM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002094">
        <property type="entry name" value="OMP26_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266759" evidence="4">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="177" mass="19616" checksum="653FC831D8C93D44" modified="2004-10-25" version="1">MLTGKFSKRVMCALALAAALGATAARAQDVARIAAVNSDRILRESAPAKAAQTKLEAEFAKRDKDLQDMAARLKSMSDALDRNGPTMSANDRAQKQRDLAQLDTDFQRKQREFREDLNQRRNEELAAVLDKANKVIKQIAEQQNYDLIVQEAVYVSPRIDITDKVLKALASPSSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T43</accession>
    <name>Q63T43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport-related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521213.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108723.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2126"/>
    <dbReference type="EnsemblBacteria" id="CAH36129">
        <property type="protein sequence ID" value="CAH36129"/>
        <property type="gene ID" value="BPSL2126"/>
    </dbReference>
    <dbReference type="GeneID" id="56529070"/>
    <dbReference type="KEGG" id="bps:BPSL2126"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3338"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HSRLVGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="5"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="406" mass="41585" checksum="8C187AB444587997" modified="2004-10-25" version="1">MTQTALPRGTVALFAGASGLSVANVYYAQPLLDALAADFTIGRAAIGGVVTATQIGCALALLLLVPLGDLVDRRRLMLVQSLALAATLIAVGFASASAVLIAGMLGTGLLGTAMTQGLVSYAASASASHERGRVVGAAQGGVVIGLLLARVLAGFVGDVAGWRGVYFLSAATMLALAALLARKLPALAPASPRIGYPRLIASLFGLLRDERVLQIRGMLAMLMFAAFNIFWSALALPLSAPPYTLSHTAIGAFGLVGALGAFAAARAGHWADRGFGQPTSAAALALLLASWLPLAFMPMSLWALVLGIVLLDAGGQAIHVTNQSMIFRARPDAHSRLIAAYMLFYSVGSGLGAIASTAVYATHGWRGVCMLGAAVSAAALIFWAATARPTPNEAASAHTANGRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T45</accession>
    <name>Q63T45_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1992 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193068.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108721.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2124"/>
    <dbReference type="EnsemblBacteria" id="CAH36127">
        <property type="protein sequence ID" value="CAH36127"/>
        <property type="gene ID" value="BPSL2124"/>
    </dbReference>
    <dbReference type="GeneID" id="56595909"/>
    <dbReference type="KEGG" id="bps:BPSL2124"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3342"/>
    <dbReference type="eggNOG" id="ENOG5032TNY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQTKGEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="133" mass="14507" checksum="77788E319C888CFA" modified="2004-10-25" version="1">MKLLDALVEQRIAAAAARGAFDDLPGAGAPMELDDDLLVPEEVRVANRILKNAGFVPPAVEQLRALRNLQDELRAVSDRATRCRLQAKMLALDMALESLRGGPMVVPREYCRRIAERLSERVLGDAQGEAGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH2</accession>
    <name>Q63TH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amine catabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192432.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108594.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1996"/>
    <dbReference type="EnsemblBacteria" id="CAH35995">
        <property type="protein sequence ID" value="CAH35995"/>
        <property type="gene ID" value="BPSL1996"/>
    </dbReference>
    <dbReference type="GeneID" id="56595401"/>
    <dbReference type="KEGG" id="bps:BPSL1996"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4148"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHCKDIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030823">
        <property type="entry name" value="IolE/MocC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04379">
        <property type="entry name" value="myo_inos_iolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="306" mass="33263" checksum="4B37A5DCC14FB490" modified="2004-10-25" version="1">MSAPDIRIGINPLSWMNDDLPSLGGETPLAVALTEGREIGYEGFELGNKFPREPQALKALLAQYDLSLVSGWYSGRLAERGVQEEIDAVGPHLELLAKNGATVMVYGEVAGTIQGSPAPLYQRPRFVDDAQWDAYAERVDAFARYTRAQGVRLGYHHHMGAYVESPADVDRLMASTSDAVGLLFDAGHMTFGGGDPVAELAKHIGRVCHVHCKDVRPAVIRLARNRNWSFLDAVIAGAFTVPGDGSIDFPTIVDMLKRHGYRGWLVVEAEQDPAVAPSYAYAQKGYRTLRALVDAPLPPVGHKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TM1</accession>
    <name>Q63TM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">relA</name>
        <name evidence="7" type="ordered locus">BPSL1946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521683.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108545.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1946"/>
    <dbReference type="EnsemblBacteria" id="CAH35945">
        <property type="protein sequence ID" value="CAH35945"/>
        <property type="gene ID" value="BPSL1946"/>
    </dbReference>
    <dbReference type="GeneID" id="56526313"/>
    <dbReference type="KEGG" id="bps:BPSL1946"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4090"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TEIGHNC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="407"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="673"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="745" mass="82346" checksum="ED977FA3D8115E57" modified="2004-10-25" version="1">MTADSASTAAAPSLDDVLAFVREHAGDARLSSGERLADHAAGTSTIMQRLNVDPPATQAAALFALAPYLSDPDKQIAEHFGDEVAHLVADVRKLLRLGTVSLRAAQSAPVDAGRDAQAERRAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKIEPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVAGAIERLQHELAAAHIQAEVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAWKDEIADGGGAEVSGQQAWAQLREATLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTQLANGQTVEIVAVKEGGPSRDWLNPQLGYLHSSRARQKVRAWFNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNVEQALSDAPAPEPEPEAPANFEKRASGANVAHGASAGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSADVLGGRGASVYPVDLMIEATDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVSSASQVQRACTLLGEIQGVVRAARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U85</accession>
    <name>Q63U85_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW2</name>
        <name evidence="2" type="ordered locus">BPSL1731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191562.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108331.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1731"/>
    <dbReference type="EnsemblBacteria" id="CAH35730">
        <property type="protein sequence ID" value="CAH35730"/>
        <property type="gene ID" value="BPSL1731"/>
    </dbReference>
    <dbReference type="GeneID" id="56595514"/>
    <dbReference type="KEGG" id="bps:BPSL1731"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3826"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERTIDTC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="170" mass="18174" checksum="8C85CD5DC380944E" modified="2004-10-25" version="1">MNAILEAPHAARMSGQDAARDAQEFVTFRLGTEEYGIDILRVQEIRSYEEPTRIANAPAFIKGVINLRGVIVPIIDLRLKFALDSAEYNTSTVVIVLNVAARTVGVVVDAVSDVLELAAADRRPAPEFGAAIDTGFITDLGSIAGENGNRMLILLDIERLIAAADVGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UK1</accession>
    <name>Q63UK1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane linked regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108215.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1599"/>
    <dbReference type="EnsemblBacteria" id="CAH35599">
        <property type="protein sequence ID" value="CAH35599"/>
        <property type="gene ID" value="BPSL1599"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1599"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1802"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3901">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLWPIKY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011399">
        <property type="entry name" value="NosR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036354">
        <property type="entry name" value="NosR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266789" evidence="5">
        <location>
            <begin position="20"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="713" mass="78621" checksum="F1899D86776E36E1" modified="2004-10-25" version="1">MTPMKALFRILLIAFFVVAARPSAASIYEQELPPELFSQPDLCKWTDCASVLPGANAFSARKGSPPYVEAYADDGHARALKGYVFLSTDIADIQGYSGKPIVTLIGMDTKGTITGVRVLKHSEPILLVGIPESKLLAFLRQYVGKFAGARFEIGNGDAGAASLDAISGATVTVIAENQLISRCAVAIASQVGIVKETVLPQAKLLPSDARETWQALVERGAIAHLAIRPDDVGAPDTGAPYLDLYYGYLNAPAIGKSILGEHEYAQLMSRLKPGEHALFVVANGTESFKGSGFVRGGIYDRIQVRQGIHAFTFKDSDYLNLYALRAAGAPSFNETGIFIVRSTRFSAAYPWKFVFLGHRSDQETGAKTFSAFASPYWLPGEFLAGGRPRVDEDAPVWRKAWAGKRLEIGLFVGWIAAVMLFFATRERWVRRAKRADKRWVSWPKTASWLIAIGFAGWHELAQPSITQVLTLVHALASGWNWGLFLSDPFIFVFWIAIAVTVLVWGRGLFCGWLCPFGSLSELLYKIARATGLKSLQRKLPAHWHNRLRKLKYAVFAVLLVVSFFSMPWAEKLAEIEPFKTTFLVGVLNRAWPFVLFWTAVVGASIFVERPFCKYLCPLGASLALPGRLRVIKLERKPECTSCHACAVGCGSQAIDPAGRIDPMECLLCLDCMVMYYDAHSCPPLSKERKRREKAGLPLTPVGKDGRYIPIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UL7</accession>
    <name>Q63UL7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192590.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108199.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1579"/>
    <dbReference type="EnsemblBacteria" id="CAH35580">
        <property type="protein sequence ID" value="CAH35580"/>
        <property type="gene ID" value="BPSL1579"/>
    </dbReference>
    <dbReference type="GeneID" id="56529304"/>
    <dbReference type="KEGG" id="bps:BPSL1579"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3630"/>
    <dbReference type="eggNOG" id="COG4377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHALVDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011397">
        <property type="entry name" value="YhfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10086">
        <property type="entry name" value="YhfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033101">
        <property type="entry name" value="UCP033101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="28404" checksum="505252B57AAE4475" modified="2004-10-25" version="1">MTVAPVTLAALVIATLVVALLPIGLYRFLRQPRALDRRDALIGVVVYTVFATLLERGLYALLLSQPSAVTWLSKPVTFAVFGTAVAALFEEVGRYLGLRWLAKRYGPSDGDARGLANGIGHGGAQAWFVGVVVLAQWVYLAWLANRGELNAQLQTMPADLALRIQVMLATMSPVSVAVSALERIAAFVVQLALSVLMWRGIRANRRWILPAMIVLHPVIDLPSLVYNGGGVPFEWMVALYLLLTAGFAGALMKLCRPARAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UP5</accession>
    <name>Q63UP5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191593.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108171.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1551"/>
    <dbReference type="EnsemblBacteria" id="CAH35552">
        <property type="protein sequence ID" value="CAH35552"/>
        <property type="gene ID" value="BPSL1551"/>
    </dbReference>
    <dbReference type="GeneID" id="56595708"/>
    <dbReference type="KEGG" id="bps:BPSL1551"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3596"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATYECDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="42872" checksum="AB716214271D80B3" modified="2004-10-25" version="1">MTGSIPFPPLMIRGRSLLPIVQGGMGVGISAHRLAGSVAREGALGTIASIDLRHHHTDLIERCKRHPDRETMEAANLEALAREIQRAKTWGEGRGMIAVNVMKAVRSHADYVRIACEFGADAIVMGAGLPLDLPDMTQGHDIALIPILSDSRGIALVLKKWMKKGRLPDAIVIEHPARAGGHLGVTSLDDMDDPRFEFARVIDETRQTFATLGLERERIALVVAGGINSHEAVRAALAEGANGVQVGTPFAVTEEGDAHPNFKRVLANAKPDDIVEFLSVTGLPARAVKTPWLERYLRHETRIRAKIGALKQRCPSALECLSVCGLRDGIERFGHFCIDTRLAAALRGDVANGLFFRGREALPFGQAIRSVRDLLELLLTGTAPEAAANRPTFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US5</accession>
    <name>Q63US5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191590.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108141.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1521"/>
    <dbReference type="EnsemblBacteria" id="CAH35522">
        <property type="protein sequence ID" value="CAH35522"/>
        <property type="gene ID" value="BPSL1521"/>
    </dbReference>
    <dbReference type="GeneID" id="56595740"/>
    <dbReference type="KEGG" id="bps:BPSL1521"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3559"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFFAFYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="31672" checksum="AAD838CFD896D9A4" modified="2004-10-25" version="1">MNRIIALVVAIVIVALVASSTVLVVDPRHTAVLSSRDGGTPALAGPGLHFKLPQPLQTATLVDVRVQTLDSADPLSLATKDKSDVLVSPVVKYRIADALKYYKETGGAPRGEADRLTAAAKGALGAAFAKRDLDDALGSQRAIADDAKRALQADAAPLGIDIVDVQLTRVDLPAAQADGAYQRMTAELQREADRERAEGAAQAEEIKAEAARQQQTILAEGYKSAQSIKGEGDAKAASIAADAFGRDPQFYQFYASLQAYRNSFKPNDVIVVDPDSEFFRFMRSPTGGAAAPAAAPRNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UU7</accession>
    <name>Y1499_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein BPSL1499</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL1499</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192342.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108119.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UU7"/>
    <dbReference type="SMR" id="Q63UU7"/>
    <dbReference type="STRING" id="272560.BPSL1499"/>
    <dbReference type="PRIDE" id="Q63UU7"/>
    <dbReference type="EnsemblBacteria" id="CAH35500">
        <property type="protein sequence ID" value="CAH35500"/>
        <property type="gene ID" value="BPSL1499"/>
    </dbReference>
    <dbReference type="GeneID" id="56595763"/>
    <dbReference type="KEGG" id="bps:BPSL1499"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3535"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000003709" description="Nucleoid-associated protein BPSL1499">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="108" mass="11785" checksum="41BA061DD3A4D396" modified="2004-10-25" version="1">MMKGQLAGLMKQAQQMQENMKKMQEQLALIEVEGQSGAGLVKVTMTCRNEVRRVAIDPSLLADDKDMLEDLVAAAFNDAVRKAEATSQEKMSGMTSGLPLPPGFKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UV9</accession>
    <name>Q63UV9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative MerR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193989.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108107.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1487"/>
    <dbReference type="EnsemblBacteria" id="CAH35488">
        <property type="protein sequence ID" value="CAH35488"/>
        <property type="gene ID" value="BPSL1487"/>
    </dbReference>
    <dbReference type="GeneID" id="56595776"/>
    <dbReference type="KEGG" id="bps:BPSL1487"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3520"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKIATYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="18100" checksum="0143124B9FB197DC" modified="2004-10-25" version="1">MSNAPKQPSPRALTIGQVAALVGVSTHTLRYYEQAGLLRSISRTPSGHRLYAPADLDWLRFVMRLKATGMPIAGMQAFAELRAQGDATFGERRALLAAHRDAVRAQIGALQTNLDSIVEKIAYYERAERDAVRQARTTTQSQPDKDERWSNAFRKTATRAAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V13</accession>
    <name>Q63V13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108053.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1431"/>
    <dbReference type="ESTHER" id="burma-q62jn5">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35433">
        <property type="protein sequence ID" value="CAH35433"/>
        <property type="gene ID" value="BPSL1431"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1431"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1606"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CWEALLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="331" mass="35975" checksum="CD493CA85D4C4A5A" modified="2004-10-25" version="1">MRCCLPRRLPLTMPLNPKIAQVLDMIERAKRPDYHEQTPAQARAAYEKSAPILDVAPAPMFSVEDLRVPSRDGGAFGARLYLPVEPSLAEPLPVLVYYHGGGFTVGSVNTHDALCRMFARDAQCAVLSVDYRLAPEHKFPTAVDDAEDALVWLHAHASRFGIDSARLAVGGDSAGGTLATVCAVLARDRGIALALQLLIYPGTVGHQQTESHARLAKGYLLSADTIQWFFGHYVRDASDRDDWRFAPLDGTRGAPSFERVAPAWIATAQYDPLSDEGEAYADKLRAAGNRVTLVAYAGMIHEFFKMGGYVPEVRLAHADAVGALRAAFDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V48</accession>
    <name>Q63V48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1396"/>
    <dbReference type="EnsemblBacteria" id="CAH35397">
        <property type="protein sequence ID" value="CAH35397"/>
        <property type="gene ID" value="BPSL1396"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1396"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3405"/>
    <dbReference type="eggNOG" id="COG2814">
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    </dbReference>
    <dbReference type="OMA" id="QNALWGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="397" mass="39969" checksum="4DB939A2A702EEEB" modified="2004-10-25" version="1">MTIKTLRQEPALAGAASPADTPAFTSGTLAALVAFAAITPLLLLVAPAVAGQLGAQLGLSASRIGTYFFVELGAFSAATLPSYLWLGRIDARRIAWGATAVFCAGNLATAVWMPGFAPLLALRAATALGGGTLMVLCMTSAAASGNSDRVYGLWVVGQLIAGAAGLFLLPHLFDMVGLRALYAVLAALALCAAPLARRFPAVPRVRAQHAPRARAQAARMAAALAIGGVLTFYVAIGGVWTFASKAASAVGLDAQTSGNVLAIASLMGIAGAALASYLGGRAARRAMLLAGYGILAASLVALAAAPNANGYTLAIFGFKFAWTFVLPFMLASVAAVDATGRLIATLNLVIGSGLAAGPLAAGLMLDGGGTLRALFSIAAAVSLVSLAAMLRVERDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V98</accession>
    <name>Q63V98_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1343</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107968.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1343"/>
    <dbReference type="EnsemblBacteria" id="CAH35341">
        <property type="protein sequence ID" value="CAH35341"/>
        <property type="gene ID" value="BPSL1343"/>
    </dbReference>
    <dbReference type="GeneID" id="56595269"/>
    <dbReference type="KEGG" id="bps:BPSL1343"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.138"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="270" mass="30514" checksum="D2713B99BB12D7CC" modified="2004-10-25" version="1">MSDRSIIDWPAWTDSPPGRYVLGWEQAQLDRTVSDVFGFHALQLGLPQLDALRENRMPCRGLVLDPASGASAPYHYPWAREARSAEHAPAGRSTVWCDLLDLPFESQSVDLIVMPHTLEFTSDPHRLLREAERVLMPEGQLVITGFNSLSLWGARHSVGKMAKRPFVPATRDQITFIRLKDWIKLLGFDLERGRFGCYRPPLATDKWLSRYAFMEAAGDRWWPIFGAVYMVTAIKRVRGMRLVGPIKMKKPVLAPGLTPAATPTTHQEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VA3</accession>
    <name>Q63VA3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutathione S-transferase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1338"/>
    <dbReference type="EnsemblBacteria" id="CAH35336">
        <property type="protein sequence ID" value="CAH35336"/>
        <property type="gene ID" value="BPSL1338"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1338"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.146"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRAINPV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034343">
        <property type="entry name" value="YibF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF12">
        <property type="entry name" value="PTHR42673:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="22989" checksum="441C944644E90EB8" modified="2004-10-25" version="1">MKLIGMLDSPFVRRVAISAKLLGLPFEHHSISVFRQFDAFKSFNPVVKAPTLLTDDGTMLVDSSLIVDYLDRLVAPQRRLVPDDLPARVRVLELTGLALAAAEKTVQVVYEHGLRPGEKQHQPWLDRVLGQLDAAYGALDARIAGASGWLVGERITQADVTVAVAWRFTQFMKGDYPDLARVDPARYPALAALSARAEALPEFEGTPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VB4</accession>
    <name>Q63VB4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative malonate transport-related system membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526555.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107952.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1327"/>
    <dbReference type="EnsemblBacteria" id="CAH35325">
        <property type="protein sequence ID" value="CAH35325"/>
        <property type="gene ID" value="BPSL1327"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1327"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.158"/>
    <dbReference type="eggNOG" id="ENOG5032RRS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LICARLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004690">
        <property type="entry name" value="Maln_transptMadL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03817">
        <property type="entry name" value="MadL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00807">
        <property type="entry name" value="malonate_madL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="131" mass="13279" checksum="FD2D873969CCA3E9" modified="2004-10-25" version="1">MIIYGTALLAFCHLAGLFLGDLLGAAIGAKTNVGGVGIAMLLLIGLRLALHRRGWLPKETEAGIAFWGAMYIPVVVAMAANQNVVAALKGGPVALLSAVGAVAVCVLSIAALARVGHDATSLAALPRPEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD9</accession>
    <name>Q63VD9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BPSL1304A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547706.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107927.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1304A"/>
    <dbReference type="EnsemblBacteria" id="CAH35300">
        <property type="protein sequence ID" value="CAH35300"/>
        <property type="gene ID" value="BPSL1304A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1304A"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1454"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKHTWRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Porin_4" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="145" mass="15212" checksum="8FAB61A41EADA306" modified="2004-10-25" version="1">MTTEPFQASNTNRHVIGAACAAVLGATATAAAHAQSSVALHGLLDASIAYTNNQSGKHTWRQGRGLPSHTVFGLSGSDGPGARLRVAPRAGRIVDAYASRGDDRHPASVPTVRSDGAPRTPPSVRRANSACRRRGRKRIGGPDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VI7</accession>
    <name>Q63VI7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526488.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107879.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1258"/>
    <dbReference type="EnsemblBacteria" id="CAH35252">
        <property type="protein sequence ID" value="CAH35252"/>
        <property type="gene ID" value="BPSL1258"/>
    </dbReference>
    <dbReference type="GeneID" id="56526600"/>
    <dbReference type="GeneID" id="66546704"/>
    <dbReference type="KEGG" id="bps:BPSL1258"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.260"/>
    <dbReference type="eggNOG" id="ENOG5034CEN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVMAIWF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="60" mass="6454" checksum="C6218FEB2F1BC4A9" modified="2004-10-25" version="1">MSDTSQRHGGDPEPHDDAVDEIVRSGPRGALALAGTATAIVIALWFAFYFLVFLPRGVIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VS6</accession>
    <name>MGSA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mgsA</name>
        <name type="ordered locus">BPSL1168</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186317.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107790.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VS6"/>
    <dbReference type="SMR" id="Q63VS6"/>
    <dbReference type="STRING" id="272560.BPSL1168"/>
    <dbReference type="EnsemblBacteria" id="CAH35163">
        <property type="protein sequence ID" value="CAH35163"/>
        <property type="gene ID" value="BPSL1168"/>
    </dbReference>
    <dbReference type="GeneID" id="56595098"/>
    <dbReference type="KEGG" id="bps:BPSL1168"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.369"/>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RACDVHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000178620" description="Methylglyoxal synthase">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <sequence length="130" mass="13654" checksum="494D74B03DDE854E" modified="2004-10-25" version="1">MSTPRIALIAHDAKKDDIVALAGAYRATLAQCRLVATGTTGGRIAQAHGLDVERKLSGPLGGDLQIGAELADGRVDIVIFLRDPMTAQPHDPDITALVRACDVHDVPVATNVATARVLLDDLARRLTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VV0</accession>
    <name>Q63VV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107766.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1145"/>
    <dbReference type="EnsemblBacteria" id="CAH35139">
        <property type="protein sequence ID" value="CAH35139"/>
        <property type="gene ID" value="BPSL1145"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1145"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.396"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="11044" checksum="139F633E20B7CBD4" modified="2004-10-25" version="1">MMSARVQQRTRGSKWMKIRARILRRDPVCVLCAEQDVVRESVVVDHITPLEHGGTDADDNLRGLCADHHDEVTRQQFGYRERKAFGPDGLPIDGSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VW9</accession>
    <name>Q63VW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198111.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107747.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1125"/>
    <dbReference type="EnsemblBacteria" id="CAH35119">
        <property type="protein sequence ID" value="CAH35119"/>
        <property type="gene ID" value="BPSL1125"/>
    </dbReference>
    <dbReference type="GeneID" id="56595074"/>
    <dbReference type="KEGG" id="bps:BPSL1125"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.423"/>
    <dbReference type="eggNOG" id="COG5455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HFTWRGD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024572">
        <property type="entry name" value="RcnB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11776">
        <property type="entry name" value="RcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266811" evidence="2">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="126" mass="13759" checksum="D90F03E417FF16F3" modified="2004-10-25" version="1">MKAHRTLRISMLAAGALVSSLAAAQPHGPGGPGDERHGPPPGKHVGRDHGKHGDDGARPGEHRGDENAAWRRGERLPDEYRDRQYVIDDWRGYHLSPPPRGYHWVGIGGDYLLVRISTGVILQIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W05</accession>
    <name>Q63W05_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107711.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1089"/>
    <dbReference type="EnsemblBacteria" id="CAH35083">
        <property type="protein sequence ID" value="CAH35083"/>
        <property type="gene ID" value="BPSL1089"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1089"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1182"/>
    <dbReference type="eggNOG" id="COG3663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QQYYAHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="17307" checksum="46271EB4D7F7AF05" modified="2004-10-25" version="1">MMLRGFPPVASPGTHTLILGSFPGEASLAAAQYYAHPRNQFWRLLGAVLGEPQLHALPYDARLARVLAHGFGIWDVLAACHREGSLDAAIRHAQPNDFASLREVAPKLTKVCFNGKTAGRFEPTIRAAGFDTLVLPSSSPANAMLSFEQKLVFWQRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W49</accession>
    <name>Q63W49_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192968.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107667.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1040"/>
    <dbReference type="EnsemblBacteria" id="CAH35036">
        <property type="protein sequence ID" value="CAH35036"/>
        <property type="gene ID" value="BPSL1040"/>
    </dbReference>
    <dbReference type="GeneID" id="56596150"/>
    <dbReference type="KEGG" id="bps:BPSL1040"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.526"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPGMAMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="446" mass="49265" checksum="7E528F1FD6EBA144" modified="2004-10-25" version="1">MQNPNAVNAPVQTPPAPPRVGEEILRVENVSRGFNKTQGELLVLDGANLSLREGEIVGLLGRSGSGKSTLLRIIAGLIEPTGGEVTYLGKPLSGPAEGVAMVFQTFALFPWLTVLQNVEAGLEALGVGARERRERALAAIDLIGLDGFENAYPRELSGGMRQRVGFARALVVDPTLLLMDEPFSALDVLTAETLRTDLLDLWTQGRMPIKSVLIVTHNIEEAVFMCDRILVLSSNPGRVIAEIKVPFKHPRNRLDPAFRRLVDDIYAKMTARQVGEATKKGLELGSWLPQVSTNLMAGLIETLAAPPYHGRADMPEIARTLHLEVDDLFPIAEVLQYLGFADVREGDVFLTPPGRVFAEFGTQERKMMFAEHLLRHVPLAARIKKVLNERPGHRAPRVRFEQELEDFLSDGAAEETLDAVIDWGRYGEIFSYNDQTEIFSLEDVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W94</accession>
    <name>Q63W94_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">POTRA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204930.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107622.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0994"/>
    <dbReference type="EnsemblBacteria" id="CAH34990">
        <property type="protein sequence ID" value="CAH34990"/>
        <property type="gene ID" value="BPSL0994"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0994"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.578"/>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTTMLLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="222"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="605" mass="65972" checksum="950065D34DF33EB1" modified="2004-10-25" version="1">MAGRAPRQQVFSRAARGAPSRSPGWHAFARHGLRVLLAGCAAVLAAPAFAKYAVEIDAPRSVRSLLKQHLDIARFAKREDLSEDQFEFLVTATPQQVRELAATAGYFSPVVRTDVRTTGGERRVTVSVDPGAQTLVSAVDLKFDGPVASEDPKQETATRLAFSLKPGDPFTQAGWDDAKNAALKQLQSRRYLGAKITASEARIDPRTRAATLALTLDSGPTFTIGALDVSGVRRYPEKIVHDVNPLAAGEIYDAKRITELQRQLQNTPYYASVAIDVADDVARPLDSPIHVKVSEYPYNSVRGGIGYATDTGPHIQGSYTYLDTFGAAWPLSVSGRIDQIQQYGQVQLSMPPGPRAWTNSILASYTNTNVSDTRIYSARVGAQRTRTGQFIDYSYSLMFYQDRLDQNGAGPTTSRALVPQWAWTRRNVDDPLFPRSGNLIHAEAGFAVKGVLTDQTFIRGYARGQQYVPIGKRDLFVFRAELGGVFTSGGSSGIPASLLFRAGGSNSVRGYGYQSIGHSVDGSVLPTKYLMTGTAEYQHWFNRDWGAATFFDIGTATDAWGEKVFYPGAGVGVRWRSPVGPVNFDLAYGLKNKSVRPYLTLGIAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W97</accession>
    <name>PANC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantothenate synthetase</fullName>
            <shortName evidence="1">PS</shortName>
            <ecNumber evidence="1">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panC</name>
        <name type="ordered locus">BPSL0991</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192993.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107619.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63W97"/>
    <dbReference type="SMR" id="Q63W97"/>
    <dbReference type="STRING" id="272560.BPSL0991"/>
    <dbReference type="EnsemblBacteria" id="CAH34987">
        <property type="protein sequence ID" value="CAH34987"/>
        <property type="gene ID" value="BPSL0991"/>
    </dbReference>
    <dbReference type="GeneID" id="56596199"/>
    <dbReference type="KEGG" id="bps:BPSL0991"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.583"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000128215" description="Pantothenate synthetase">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>beta-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <sequence length="279" mass="31207" checksum="E5C90D9C6DB1001F" modified="2004-10-25" version="1">MKVISSIQELRDQLRGQNRTAFVPTMGNLHDGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDQYPRTLQDDIEKLQKENVYVLFAPTERDMYPEPQEYRVQPPHDLGDILEGEFRPGFFTGVCTVVTKLMACVQPRVAVFGKKDYQQLMIVRRMCQQLALPVEIIAAETVRDADGLALSSRNRYLSEAERAEAPELAKTLAQVRSAVLGGERDLAAIEQRALAHLAARGWKPDYVSIRRRANLVAPSAAHIEAGEPLVVLTAAKLGATRLIDNLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WD9</accession>
    <name>Q63WD9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204925.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107577.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0948"/>
    <dbReference type="REBASE" id="10398">
        <property type="entry name" value="M.BpsKORF945P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34944">
        <property type="protein sequence ID" value="CAH34944"/>
        <property type="gene ID" value="BPSL0948"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0948"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.629"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRHFYKY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="153"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="613" mass="68870" checksum="E2949E7927941490" modified="2004-10-25" version="1">MNHQALSSFIWSVADLLRGDYKQSEYGRVILPFTVLRRLDCVLESTKSAVLAEFEAKSKKGLNPEPFLLRIVGDAKFYNTSPLDLVKLLGDQDHIRQNLYAYIQAFSPAARDIFERFDFYTQVERLAKADLLYLVTEKFANIDLHPTAVDNAQMGLVFEELIRKFAEISNETAGEHFTPREVIRLMVNLLFIEDDDVLTPGNAVVRAIYDPTAGTGGMLSVAGEFLLEHNPVARLRMYGQELNDESYAICKADMLIKGQDVENIVAGNTLSDDGHAGRQFDYMLSNPPFGVEWKKVEKTVRAEYEQKGFAGRFGPGLPRVSDGSMLFLLHLLSKMRPAQEGGSRFGIVLNGSPLFTGGAGSGESEIRRYVLENDLVEAIVGLPTDMFYNTGIATYVWILSNRKPETRKGFVQLIDASSFWQKMRKSLGSKRREMSDEHIDTVTRLFGNFVEAELTTVFDAEGKELGRWVVPAGSNVPNVPAGGKVKSVPISRIFRNQEFGYTTITVERALRDEQGKVVLGVKGKQKGKPQADSSLRDTENVPLSDDIGVYFEREVLPHAPDAWIDEQKNKVGYEIPFNRHFYVFEPPRDLHTIDEELKAVSANIMRMLEELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WS0</accession>
    <name>Q63WS0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transporter permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200770.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107446.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0822"/>
    <dbReference type="EnsemblBacteria" id="CAH34813">
        <property type="protein sequence ID" value="CAH34813"/>
        <property type="gene ID" value="BPSL0822"/>
    </dbReference>
    <dbReference type="GeneID" id="56596540"/>
    <dbReference type="KEGG" id="bps:BPSL0822"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.780"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALMGDGI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="263" mass="26950" checksum="F33016A24D7BAD34" modified="2004-10-25" version="1">MFEYEFMINAFAAAGIVAVLAGIVGYFLVLRGQTFAGHALSHVGFAGATGAALFGLSPIWGMLGFTLAAGIGMGALGERLAGRDVAIGVILSVALGCGLLFLHFYTNYATQVTALLFGNVLGVSHATLVVLAAIGAVSLAALAAIARPLLFASLQPELAEAKGVSLRLVSILFLSIGALAVAACTQIVGVLLVFTLLVGPAAAAQNLATRLSTGVWLAAAFALGEAWLGITLAYYTDWPTSFWITALSALVYGASLVGRRHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WT1</accession>
    <name>Q63WT1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552485.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107435.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0810"/>
    <dbReference type="EnsemblBacteria" id="CAH34802">
        <property type="protein sequence ID" value="CAH34802"/>
        <property type="gene ID" value="BPSL0810"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0810"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.793"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDASYFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="121" mass="13446" checksum="623038DD83CF58F7" modified="2004-10-25" version="1">MSDAAGHRIEIEPNRHRVRVIHRGITYADSLAAYTLREPGAPEVQYLPRDDVNMSRLVPSDRVALEPCAHKGPATYFHLHTEDGVIENAAWSYEEPSGIASAIRQYVAFDAACVDRIDVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X27</accession>
    <name>Q63X27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107339.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0711"/>
    <dbReference type="EnsemblBacteria" id="CAH34704">
        <property type="protein sequence ID" value="CAH34704"/>
        <property type="gene ID" value="BPSL0711"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0711"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.777"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="112" mass="11676" checksum="4CB41471329F4BD5" modified="2004-10-25" version="1">MPRAVHRPGACAATQARRGPNDARRRDASSPGVDARRTRVRRALFWRSIMVAGVVLWVALAVIFPTVVVPAAQHALERTIKQHDAGASAPGAPRGGTPGQSASPGGGEAIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XK5</accession>
    <name>Q63XK5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system protein LptA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lptA</name>
        <name evidence="6" type="ordered locus">BPSL0535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the lipopolysaccharide transport and assembly complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LptA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936242.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107160.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0535"/>
    <dbReference type="EnsemblBacteria" id="CAH34524">
        <property type="protein sequence ID" value="CAH34524"/>
        <property type="gene ID" value="BPSL0535"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0535"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1113"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VPTQQME"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01914">
        <property type="entry name" value="LPS_assembly_LptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014340">
        <property type="entry name" value="LptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03002">
        <property type="entry name" value="outer_YhbN_LptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019279" description="Lipopolysaccharide export system protein LptA" evidence="3">
        <location>
            <begin position="40"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="5">
        <location>
            <begin position="49"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="221" mass="23276" checksum="FC55722D6D43FC27" modified="2004-10-25" version="1" precursor="true">MNESFPCLFPSGARRAARAMVAAALVAAPLAGLAPAAHAEKADRDKPINVEADNLTYDDLKQVTVATGNVVITKGTILIKGDRVEVRQDPQGYQYATATASGKKHASFRQKREGLDEYIDGDAERIDYDGKQDLTTLTTNATVRRLQGVSTIADTVHGSVITYDGQRDFYTARGGKDVAGPGNPGGRVRAMLTPKNSGPAPLSGGPAQLAPSNDMQGAPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP9</accession>
    <name>Q63XP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195330.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107116.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0491"/>
    <dbReference type="EnsemblBacteria" id="CAH34480">
        <property type="protein sequence ID" value="CAH34480"/>
        <property type="gene ID" value="BPSL0491"/>
    </dbReference>
    <dbReference type="GeneID" id="56593856"/>
    <dbReference type="KEGG" id="bps:BPSL0491"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1164"/>
    <dbReference type="eggNOG" id="ENOG50349RB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="82" mass="8838" checksum="A0A6EFBE178F0677" modified="2004-10-25" version="1">MSTPAAETLPLLAREVAKILHVETVETNVGIGELGIDSLNIVELIVFCEQLYGSIDPETLNITQYTTLAQLDAELRAPQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y41</accession>
    <name>Q63Y41_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative insertion element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525957.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106974.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0347"/>
    <dbReference type="EnsemblBacteria" id="CAH34336">
        <property type="protein sequence ID" value="CAH34336"/>
        <property type="gene ID" value="BPSL0347"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0347"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="18465" checksum="07B7EC64B8DA84EA" modified="2004-10-25" version="1">MANSRAASACAEAAPARYPGRKPLDDRAVLTGIPFVLQSGIPWEMLPQAIGCASGMSCRRRLRHRQQVGVWDRVHEVFLAKRRAADRIDWSRVVIDSSAIRGMACRRSPPVGERSAALRRGALTMNVDGASRRTKSGSAAIAPCSGTRHTDRRAEHAPPCRNLSPSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y68</accession>
    <name>Q63Y68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB family carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189262.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106947.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0320"/>
    <dbReference type="EnsemblBacteria" id="CAH34309">
        <property type="protein sequence ID" value="CAH34309"/>
        <property type="gene ID" value="BPSL0320"/>
    </dbReference>
    <dbReference type="GeneID" id="56594644"/>
    <dbReference type="KEGG" id="bps:BPSL0320"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1366"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPYNTAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="32191" checksum="A03C0D9B72AF2C4B" modified="2004-10-25" version="1">MSAGFPQFVSAGDILTDMVRTGGAHWTSRPGGAGWNVARAVARLGAPSACAGAVGRDCFSDELWRESEAAGLDLRFLQRVERAPLLAIVHETQPPAYFFIGENSADLAFDPQRLPDGWREHVKWAHFGCISLVREPLASTLVALAAELREAGVKISFDPNYRNLMTDSYRPTLARMAELADLIKVSDEDLRHLFAGDDEASAIARLRALNPRAALLVTRGPDTATLYAGGETIDARPPRIEVADTVGAGDATIGGLLFSLMTVPARGWRAHLSFALAAGAAACRHTGAHAPTLDEVVALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y78</accession>
    <name>Q63Y78_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188983.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106937.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0310"/>
    <dbReference type="EnsemblBacteria" id="CAH34299">
        <property type="protein sequence ID" value="CAH34299"/>
        <property type="gene ID" value="BPSL0310"/>
    </dbReference>
    <dbReference type="GeneID" id="56594654"/>
    <dbReference type="KEGG" id="bps:BPSL0310"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1379"/>
    <dbReference type="eggNOG" id="COG5569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMVVNEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021647">
        <property type="entry name" value="CusF_Ec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042230">
        <property type="entry name" value="CusF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11604">
        <property type="entry name" value="CusF_Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266424" evidence="2">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="11793" checksum="0A4A03725C0EADBC" modified="2004-10-25" version="1">MKQWIAALMTLAAAAAPAFAAEAAAGPNTPAPPRDARPPAGDALTEAVVRQVDLATGMITLKHGALDNVGMPPMTMTFKAKDIAMAKRVRAGDSVRVRVENVDGVMTVVKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YD6</accession>
    <name>Q63YD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative dipeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dppD</name>
        <name evidence="10" type="ordered locus">BPSL0252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_004525887.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106879.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0252"/>
    <dbReference type="EnsemblBacteria" id="CAH34240">
        <property type="protein sequence ID" value="CAH34240"/>
        <property type="gene ID" value="BPSL0252"/>
    </dbReference>
    <dbReference type="GeneID" id="56527505"/>
    <dbReference type="KEGG" id="bps:BPSL0252"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1457"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GSMPRID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="330" mass="35365" checksum="8D0712FE54D6A579" modified="2004-10-25" version="1">MSDLLTIRNLAVNFSGLPAVDRINLSIARGEVVGVVGESGSGKSVTMMALMGLIDAPGIVTADEVTFDGVDLLKASAKARRRIIGKDVAMVFQDALTSLNPSYTVGYQIKEVLKLHEGLRGDALNKRALELLDQVGIPDARNRIGTFPHQMSGGMNQRVMIAMAVACNPKLLIADEPTTALDVTIQAQIMDLLVTLQKERGMALVLISHDLAVVSEVAQRVAVMYAGEIIETNRVPDIFAHPHHPYTEALLAAIPEHNAGAKRLAALPGMVPGRDDRPSGCLFAPRCKYVVDDCMKARPTLAELAPGTGMRARCIKPLNLEAPHTQGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YG1</accession>
    <name>Q63YG1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliJ</name>
        <name evidence="12" type="ordered locus">BPSL0226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197162.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106854.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0226"/>
    <dbReference type="EnsemblBacteria" id="CAH34214">
        <property type="protein sequence ID" value="CAH34214"/>
        <property type="gene ID" value="BPSL0226"/>
    </dbReference>
    <dbReference type="GeneID" id="56594425"/>
    <dbReference type="KEGG" id="bps:BPSL0226"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1486"/>
    <dbReference type="eggNOG" id="COG2882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRDQKLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018006">
        <property type="entry name" value="Flag_FliJ_proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019404">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01004">
        <property type="entry name" value="FLGFLIJ"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="17099" checksum="D252D1732053E5FF" modified="2004-10-25" version="1">MAQSFPLQLLLERAQDDLDTAAKQLGRAQRERTDAQAQLDALMRYRDEYRVRFAESAQSGMPAGNWRNFQAFLDTLDAAIEQQRRVLAAAQTRIDAARPEWQAKKRTLGSYEILQARGARQDAQRAAKREQRDADEHAAKVLRMRADAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YX6</accession>
    <name>Q63YX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-methylacyl-CoA racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525804.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106689.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0064"/>
    <dbReference type="EnsemblBacteria" id="CAH34047">
        <property type="protein sequence ID" value="CAH34047"/>
        <property type="gene ID" value="BPSL0064"/>
    </dbReference>
    <dbReference type="GeneID" id="56527658"/>
    <dbReference type="KEGG" id="bps:BPSL0064"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.71"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEPQFMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="377" mass="39752" checksum="AA4D07D5D79F64DD" modified="2004-10-25" version="1">MGPLHGIRIVEIAGIGPAPFCGMLLADMGADVILVERTAGRDGDPLDLGRRAIFNRGKRSLALDLKQPEAVGAVLRLVEHADALIEGMRPGVMERLGLGPDTCFARNPKLVYGRMTGWGQDGPLAHAAGHDINYIGLSGALWYAGQPGDAPFAPPTLVGDLGGGALYLAMGVLAGIVDARLRGKGQIVDAAIVDGSANLMNLLLSIHAAGFMPMARGQGLLDGPHWYGSYRCACGGYVSVGALEPQFYALLVDKLGLADDDDFRNPYDASRWPRLRERLAEIFASRPRAHWVELMEGTDACFAPVLSPAEAQSHPHLAARGVYAQRDGILQAAPAPRFSGSPNAQPGAVPKRGADSAAILREAGFAEDEIAALAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z21</accession>
    <name>Q63Z21_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">General secretory pathway protein L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gspL</name>
        <name evidence="14" type="ordered locus">BPSL0016</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP L family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533517.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106641.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0016"/>
    <dbReference type="EnsemblBacteria" id="CAH33999">
        <property type="protein sequence ID" value="CAH33999"/>
        <property type="gene ID" value="BPSL0016"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0016"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1731"/>
    <dbReference type="eggNOG" id="COG3297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDLAQFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009276">
        <property type="term" value="C:Gram-negative-bacterium-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024230">
        <property type="entry name" value="GspL_cyto_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025691">
        <property type="entry name" value="GspL_pp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007812">
        <property type="entry name" value="T2SS_protein-GspL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12693">
        <property type="entry name" value="GspL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05134">
        <property type="entry name" value="T2SSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01709">
        <property type="entry name" value="typeII_sec_gspL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSL" evidence="12">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="GspL_C" evidence="13">
        <location>
            <begin position="331"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="476" mass="50683" checksum="41DB7A02D3EC09C4" modified="2004-10-25" version="1">MSTLIVLLPPREPAVPLQEWQWPELPFALVDKSGHTQRAGRAALALLPQAATTVLIVAARDLLMLEQALPPLKGPRLKQALPNIIEDQLIQDPQGCHIAVDPAALDGGRRVLAVIDRAWFKFIVDAFTAAGHRHLRAVPVTRCLPPATRRDAAAAAETEAVADVALDRPAGHAAAADAPGSGHAGATANAPAPAESIVAVALGLAATERAPSLAEEPAALLPQAPSAPRVELALARGALGEGFAAPVSSAVATLEALANGTPLELYELGEPGAEPQLASVRPLDDKRLLPGAAIWPFDALVRRALDSRFDLCQFEFEFAPWRFDRATFMRLRLPLALAATTLAIAVIGANAHWWKLSRERDALAAQITETLLSTFPKTTTVLDPAAQMTRQLDRLRIAAGELSPNDFLSLASGLARSLGPLPPNGIASLDYHDRRLDVGFKPETKVDPDFAQRLARNGLTGEIDSSTGKWTIRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>H7C767</accession>
    <name>H7C767_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative capsular polysaccharide biosynthesis/export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wcbC</name>
        <name evidence="4" type="ordered locus">BPSL2807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194378.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109402.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2807"/>
    <dbReference type="EnsemblBacteria" id="CAH36817">
        <property type="protein sequence ID" value="CAH36817"/>
        <property type="gene ID" value="BPSL2807"/>
    </dbReference>
    <dbReference type="GeneID" id="56594703"/>
    <dbReference type="KEGG" id="bps:BPSL2807"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3203"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRADARN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003609283" evidence="2">
        <location>
            <begin position="22"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="387" mass="40907" checksum="C891134CE587BB32" modified="2012-04-18" version="1">MSRPFCKTFLIACVMGAVTLAGCSSIPTSGASGAQIARAAQSPSGIQIVDVTEDVARQLFADRNTADFVTALGGGASFRQQLGVGDTIQVSIWEAPPATLFGAAQSEGSSGPANARVTVLPDQAIDGDGNVNIPFAGQVKAAGRSPTQLAREIAARLKSMAHDPQVLVKLSRNETSYVTVVGDVAENARMALTARGERLLDALASAGGAKHPVDKVTIQITRGKTVASLPLDMVIRDPRQNVPLHAGDVVTVLFQPYSFTVLGATGKNDEINFEAKGITLAQALARAGGLQDSRADAKGVFIFRLEDANALKWPTAPVRTTADGKVPVVYRVNLRDPNSFFVAQSFRVDNNDLLYVSNAPIAELQKFLNVVFSVAYPVITGVQTVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HS0</accession>
    <name>Q63HS0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative partition protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194446.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112352.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2349"/>
    <dbReference type="EnsemblBacteria" id="CAH39836">
        <property type="protein sequence ID" value="CAH39836"/>
        <property type="gene ID" value="BPSS2349"/>
    </dbReference>
    <dbReference type="GeneID" id="56598465"/>
    <dbReference type="KEGG" id="bps:BPSS2349"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5992"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SPMDLWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="220" mass="23850" checksum="9AD73FB8BC07F707" modified="2004-10-25" version="1">MAAEIIAVTQQKGGVGKSTIAMHLGAAFHEKGRRVLVIDADGQNTLVHWSSSSADSESGIPFPVVNLAEAGSQIHREIKKFINDYDIIIVDCPPSITEKVSGVVLLAATIAVIPTSSSPADYWSSVGLVKLIQQAQVMNEDLRAVFLLNKTEEKRMLTRELKRALEELGFPLLKTQIPTREAYKQAMALGQTVLQMNDRGAKLAAAEIRACADEIVAMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HU4</accession>
    <name>Q63HU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530640.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112328.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2326"/>
    <dbReference type="EnsemblBacteria" id="CAH39812">
        <property type="protein sequence ID" value="CAH39812"/>
        <property type="gene ID" value="BPSS2326"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2326"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5961"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMIKEVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="495" mass="55648" checksum="775EC0136173DC57" modified="2004-10-25" version="1">MTTTTNTTANTTTEPAAPGAARAAPATPPIRDCLDRYCIIGGGAAGIATAKNLREHGIAFDLIEREDDIGGTWYYGKPCSAIYQSVHMISSREFSEYTDYPMPADYPTYARGDQALAYLRDYARRFGVYEHAQFNRTVLEVAPLAHGGAWRVELDGHDVRHYKGVFVCNGHLSKPQVPDYPGRFDGLQLHSALYKTPDVLKGKRVLVVGAGNSGCDIAVEAVHHASAVFHSTRRGYFYWPKFLFGIPADRWAEWPLKLRMPLWARRFFGERLLRLTTAGQPEDYGLPKPDHKLFEAHFIINSTLFYHLGHGDLVAKPDVVELKGDRVAFSDGSEERIDAIVYATGFQLSFPFLDQSYLQWDKMQPRLYLNMFDRAHPNLFFIGLFQTSTGNWPLMDYQAQLVARYLRARDAAPRKAARLDRMIGRDRSNWNGGIRFSDTQRHVIEVEHFAYRLQLKRLIRALPDSRVAARQARPVAVASAVPAPAAAARARTGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE6</accession>
    <name>Q63IE6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative IclR transcriptional regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190404.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112126.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2127"/>
    <dbReference type="EnsemblBacteria" id="CAH39608">
        <property type="protein sequence ID" value="CAH39608"/>
        <property type="gene ID" value="BPSS2127"/>
    </dbReference>
    <dbReference type="GeneID" id="56598150"/>
    <dbReference type="KEGG" id="bps:BPSS2127"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5682"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AHISLFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="89"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="30226" checksum="4E7D15A86C9A4D27" modified="2004-10-25" version="1">MKPRKDAPAGAAQAPHDCEEIERYRAPALDKGLDILELLAEQKEGLTRTEITKELGRNASEIYRMLERLVARQYVIRSPGGDRYTLSLKLYSLAHRHPPLKRLIAEALPPMQRFADAAEQSCHLCVYDRGNLLVIAQVDGPGAWGISVRLGSRVGLVDTASGPVLLAFQTPEQRARMLVEHTKVEGEIALDMREFDALLHEIRATGRLRQKSRQAFGVTDIAYPVLGPSGHAIAALTCPYVRRIDTHAAPCAEDVDAQLRATARHLSMLKEAAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF8</accession>
    <name>SDHD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable D-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-serine deaminase</fullName>
            <shortName evidence="1">DSD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dsdA</name>
        <name type="ordered locus">BPSS2116</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine/threonine dehydratase family. DsdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524797.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112114.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63IF8"/>
    <dbReference type="SMR" id="Q63IF8"/>
    <dbReference type="STRING" id="272560.BPSS2116"/>
    <dbReference type="EnsemblBacteria" id="CAH39596">
        <property type="protein sequence ID" value="CAH39596"/>
        <property type="gene ID" value="BPSS2116"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2116"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5662"/>
    <dbReference type="eggNOG" id="COG3048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESDPNCF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046416">
        <property type="term" value="P:D-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01030">
        <property type="entry name" value="D_Ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011780">
        <property type="entry name" value="D_Ser_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF9">
        <property type="entry name" value="PTHR48078:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02035">
        <property type="entry name" value="D_Ser_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000185609" description="Probable D-serine dehydratase">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01030"/>
        </source>
    </evidence>
    <sequence length="445" mass="46320" checksum="F0184C08A28ABAD6" modified="2004-10-25" version="1">MPVGRSLSLDPNLLAQLQSHSPTLWLNPHQGMPLPDFAPTAADLADADARLRRCAGLLAELFAELRPSGGLIASPLQPAEPLKRAARAGHAQAGAWYVKRDDALPVAGSIKARGGFHEVLALAESIAERHGLAGADTDRRALASGAARARFARHTVMVGSTGNLGLSIGMLASALGFRTVVHMSADAKAWKKARLRTRGVEVVEHAGDYAKAVDAGRRQAAGMPCCHFVDDEGSRMLFLGYATAAAELAAQLAQAGRPVDARHPLFVHLPCGVGGAPGGIVYGLKALYGEHVHAFVAEPTASPCVLVQLAGDAAHPRSVYDIGLDNRTEADGLAVAQASPLAAALLRAQAAGAFTVDDRQLFAHLLDARERLGIDLEPSAAAAFGGPAWIAGSDAGRAYLRGRGIDPDAATHVIWATGGSLVPAQEHRRFQAHARAQRQVGGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IV9</accession>
    <name>Q63IV9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphofructokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111963.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1957"/>
    <dbReference type="EnsemblBacteria" id="CAH39435">
        <property type="protein sequence ID" value="CAH39435"/>
        <property type="gene ID" value="BPSS1957"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1957"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5449"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QLNEPGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="13"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="31942" checksum="2CE607B495039439" modified="2004-10-25" version="1">MPEIVTLTPNPAIDVATCVERVTDTRKLRCGPARRDPGGGGINVARVLTRLGADCSAVYLAGGGTGLALRGLLADEGVRAHGIDIAGETRENFSVLETSTGREFRFVLPGPALAAHEWPRCVEALGRLADASRYLVMSGSLPPGMPDDCYARLARRASARGVRTVVDTSGPALAAALDAGVYLVKPSLGELRALTGLPLEDDGARLAAARAIVAGGRAQIVALTLGDAGALVVSRDDAVRLPGVKVAVRSAIGAGDSFVAGLVAALNRGANVADAARHALAAASASLLSTGTALGTKEDIARIYRELPGTIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JA0</accession>
    <name>Q63JA0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529073.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111822.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1818"/>
    <dbReference type="EnsemblBacteria" id="CAH39294">
        <property type="protein sequence ID" value="CAH39294"/>
        <property type="gene ID" value="BPSS1818"/>
    </dbReference>
    <dbReference type="GeneID" id="56529766"/>
    <dbReference type="KEGG" id="bps:BPSS1818"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5264"/>
    <dbReference type="eggNOG" id="COG4291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFSLHYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009781">
        <property type="entry name" value="DUF1345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07077">
        <property type="entry name" value="DUF1345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="217" mass="24392" checksum="3593D77EB21EFDF1" modified="2004-10-25" version="1">MTFYPQVLRNRPRMVIAVAAGVALGLLFPYPLRPFARVLIGWDCTIWLYLVLMWVRMVRAHHHKVREIAMREDENATMVLTIICFATVASIAAIVLELVSAKSVGFRSGLGHYAVTGATMFGAWFLIPTIFTLHYARLYYLSPKEARAMAFPDRELEPDYWDFLYFSFTIAVASQTADVSLRGRSIRRAALAQSILSFYFNMAVLGLSVNVAAGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JB5</accession>
    <name>Q63JB5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533441.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111807.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1803"/>
    <dbReference type="EnsemblBacteria" id="CAH39279">
        <property type="protein sequence ID" value="CAH39279"/>
        <property type="gene ID" value="BPSS1803"/>
    </dbReference>
    <dbReference type="GeneID" id="56598235"/>
    <dbReference type="KEGG" id="bps:BPSS1803"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5245"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TEAGFHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="31150" checksum="329451D8BD4B4711" modified="2004-10-25" version="1">MNDCARDIAPDRDQIRIGSGAPGIERVEAHFLDHAFTPHRHDTYAIGITLSGLQTFGYLGEIHHCLPGQCHILHPDELHDGRAGTDEGFGYRIIYVDPALVQEALGGRMLPFVRSPIFQAPAVSEALAAGIWNLDEEIDNVSRIDIAVAVANLLTAAAAKGSAPKAGPLAMVELTRIRDIIASCPHEPISMDALEHASGLDRWTIARQFRRLFGTSPSRFRTQRQLNLVRRLLMEGESLSTASTDAGFSDQSHMSRHFKSTYGITPGAWISAVRTRHAQHPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JZ7</accession>
    <name>Q63JZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative N-acylhomoserine lactone-dependent regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188690.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111575.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1569"/>
    <dbReference type="DNASU" id="3095343"/>
    <dbReference type="EnsemblBacteria" id="CAH39042">
        <property type="protein sequence ID" value="CAH39042"/>
        <property type="gene ID" value="BPSS1569"/>
    </dbReference>
    <dbReference type="GeneID" id="56597918"/>
    <dbReference type="KEGG" id="bps:BPSS1569"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4939"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NFHIRSV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005143">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036693">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03472">
        <property type="entry name" value="Autoind_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75516">
        <property type="entry name" value="SSF75516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="230" mass="26029" checksum="E7DB3E8C8C666BC0" modified="2004-10-25" version="1">MLSAALPESRDVRTLVETFRQAALQIGYQHHAIVELSGASHPASIDVVSLHYPSEWVEHYTRNDYFAIDPVHRAAFRYSTPFSWNDVATANLRERHLLMEAEDAGLDNGISIPLHQPLGRVLLVSLSGTAPTHDADAKWRNAYLLGMQFNLQFQSMRTCRPIPPSVHLTDREQMCLTWVARGKSSWVIANMLDISKYTVDFHIENAMEKLNTRSRTFAAVKATRQGLIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K25</accession>
    <name>Q63K25_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Surface presentation of antigens protein</fullName>
            <ecNumber evidence="12">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">bsaS</name>
        <name evidence="12" type="ordered locus">BPSS1541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="12"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525313.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111547.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1541"/>
    <dbReference type="EnsemblBacteria" id="CAH39014">
        <property type="protein sequence ID" value="CAH39014"/>
        <property type="gene ID" value="BPSS1541"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1541"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4896"/>
    <dbReference type="eggNOG" id="COG1157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVLDYHE"/>
    <dbReference type="BRENDA" id="7.4.2.8">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="157"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="435" mass="46801" checksum="6BA24ADCA9AF3E6F" modified="2004-10-25" version="1">MKAAGDPLRLLARRAHPRRIQGPIIEAPLPEVAIGELCAIRAAAGSDTTIGRAQVVGFGRDTAILSTLGSTAGLSRQVALVPTGERMTIDVSPALLGAVVDATGGIVETFGAPPPAGAAPGRRAIDAAPPDYAARRPIERRLATGVRAIDGLLACGVGQRFGIFAAAGCGKTSLMNMMIEHAAADVYVVALIGERGREVSEFVERMRRSGSRDRTVVVYATSDRSSVDRCNAALVATTIAEYFRDLGCDVMLFLDSMTRYARALRDLALATGEAPARRGYPASVFEQLPRLLERPGRTRAGSITAFYTVLLENEEEPDPIGDEIRSIVDGHVYLSRQLGAKGHFPAIDVLRSASRLFDEIADAPHRALAKRFRQHLARIDEMQVFLDLGEYRRGENPENDDALDRRPALDAFLQQAVDEASAFGDTLERLSEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K30</accession>
    <name>Q63K30_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surface presentation of antigens protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bsaX</name>
        <name evidence="8" type="ordered locus">BPSS1536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187417.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111542.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1536"/>
    <dbReference type="EnsemblBacteria" id="CAH39009">
        <property type="protein sequence ID" value="CAH39009"/>
        <property type="gene ID" value="BPSS1536"/>
    </dbReference>
    <dbReference type="GeneID" id="56597881"/>
    <dbReference type="GeneID" id="66549613"/>
    <dbReference type="KEGG" id="bps:BPSS1536"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4891"/>
    <dbReference type="eggNOG" id="COG4794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IKLLAVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006306">
        <property type="entry name" value="T3SS_HrpO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01403">
        <property type="entry name" value="fliQ_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="84" mass="8862" checksum="E62143B1D0F9CE02" modified="2004-10-25" version="1">MAELTYAGDKAILLVILLCAAPVAVATVVGLAIGLFQTVTQLQEQTLPFGLKMLAVFGCLMMLSGWFGGKLLAFATEMLSIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K88</accession>
    <name>Q63K88_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR family transcriptional regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525363.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111484.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1477"/>
    <dbReference type="EnsemblBacteria" id="CAH38949">
        <property type="protein sequence ID" value="CAH38949"/>
        <property type="gene ID" value="BPSS1477"/>
    </dbReference>
    <dbReference type="GeneID" id="56530109"/>
    <dbReference type="KEGG" id="bps:BPSS1477"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4818"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWDTVEN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="26993" checksum="A954CC94ADF2CFF1" modified="2004-10-25" version="1">MSDKEPAEDVVVAALNGFVLDAERSYTQQVHALLRNAIVRGALPPRTALSEAVISATIDVSRTPVREALAQLADERLVQIYRKVGTLVAPISVSMLEEGRFARGTLECANHVDLAQKITPAQLAELARLVDAQRDAVAAHDVDTFFTLDETMHGRMFEFAGRPHVWAMLQPMKRQFDRVRWLLLDRVEDHARRALHEHEQILAHIAARNMALLGASVAVHVDRVNAHLPEVRERAPHYFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE6</accession>
    <name>Q63KE6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200845.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111426.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1414"/>
    <dbReference type="EnsemblBacteria" id="CAH38889">
        <property type="protein sequence ID" value="CAH38889"/>
        <property type="gene ID" value="BPSS1414"/>
    </dbReference>
    <dbReference type="GeneID" id="56530166"/>
    <dbReference type="KEGG" id="bps:BPSS1414"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4738"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QNHMYNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="25358" checksum="D4ADC69574564BB6" modified="2004-10-25" version="1">MFEKIPTRAMSDTVAQQLLKQIEIGGFAGTGKLPTEAVLAQEFGVSRTVIREAISRLKNEGVVEPRQGSGVYIARHAAIRPLRIDYAEAVEASSLPHLLAVRRAIEAEVAAEAALCRTDEDMEDIDAALAKIDDAVAEGRDGVAEDVAFHRTIASVTGNPYFLKTLSFLNQYLEAGVKVTRGNEATREDFSRQVREEHAAIADAIRARDPSAAGNAARAHMYNAARRLEQAGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KI6</accession>
    <name>Q63KI6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551806.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111386.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38847">
        <property type="protein sequence ID" value="CAH38847"/>
        <property type="gene ID" value="BPSS1375"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1375"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4691"/>
    <dbReference type="eggNOG" id="COG5478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHTLREK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20108" checksum="ACC67AA9016F48BB" modified="2004-10-25" version="1">MRETNDKQQRGNVTQRHDTPAAPGGNRVTQAFERFAARVTQWAGSPVAFGVAVAITIGWLACGPLVHFSDAWQLVINTGTTIITFLMVFLLQRNQNRDSVALHLKLDELVAATKSASNRLIGIEDASEDELKRLAHAYLELALRARTLRETSGEPARRDADADSDGDGDGDDAASEAQERPTPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KL2</accession>
    <name>Q63KL2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dTDP-rhamnosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530795.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111359.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1349"/>
    <dbReference type="EnsemblBacteria" id="CAH38820">
        <property type="protein sequence ID" value="CAH38820"/>
        <property type="gene ID" value="BPSS1349"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1349"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4653"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FARVGPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006446">
        <property type="entry name" value="RhaTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01556">
        <property type="entry name" value="rhamnosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="331" mass="36170" checksum="0E4271EC00AECAD3" modified="2004-10-25" version="1">MTTLGALVILYYPTDEQLSGLEALARDSDALAVIDNTPHEHAAARERVRALAARAHGEARVVWRHHGNRGGVAGAYNAGLSALFAQGMEAVALFDQDSTVPAAYFARMRDACAQLGTQPGAHAGAFIAGPRIYDANEQRFLPELMTSGVAVRRVRVEGERAPQRCAFLISSGSVISRGAYARLGRFDEALFIDHVDTEYCLRALAHNVPLYVVPSLVLTHRIGARRRHKVGPFELTAMHHGGLRRYYGARNAMQLGLQYGLRFPVALVPNLLTIWQVVQVVLCEREKGAKLRGIALGVLDGVFGRLGSFEAARAGHRTAREEAMREARQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KW7</accession>
    <name>Q63KW7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198743.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111254.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1246"/>
    <dbReference type="EnsemblBacteria" id="CAH38713">
        <property type="protein sequence ID" value="CAH38713"/>
        <property type="gene ID" value="BPSS1246"/>
    </dbReference>
    <dbReference type="GeneID" id="56597465"/>
    <dbReference type="KEGG" id="bps:BPSS1246"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4502"/>
    <dbReference type="eggNOG" id="COG3707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QKTSMDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="198" mass="22023" checksum="8BC8662014014303" modified="2004-10-25" version="1">MGTTDQPSKLRVLLVTDTDKPIGELRDTLARLGYEMLDEVATPARLPAAVEEQRPDVVIIDTESPSRDTLEQLAVMNATAPRPVLMFSHDADQQLIRAAVGAGVSAYLIEGLSAERLAPILEVALARFSHDEQLRQRLAEVESELAERKLIDRAKRMLMDRRKLSEQDAYATLRRSAMDQGIRIVEAARRLLAAHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LB6</accession>
    <name>Q63LB6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ProQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205535.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111105.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1092"/>
    <dbReference type="EnsemblBacteria" id="CAH38560">
        <property type="protein sequence ID" value="CAH38560"/>
        <property type="gene ID" value="BPSS1092"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1092"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4294"/>
    <dbReference type="eggNOG" id="COG3109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QAIATWC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034057">
        <property type="term" value="F:RNA strand-exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023529">
        <property type="entry name" value="ProQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016103">
        <property type="entry name" value="ProQ/FinO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036442">
        <property type="entry name" value="ProQ/FinO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38106">
        <property type="entry name" value="PTHR38106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04352">
        <property type="entry name" value="ProQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00945">
        <property type="entry name" value="ProQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48657">
        <property type="entry name" value="SSF48657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ProQ" evidence="4">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="19889" checksum="D39487B75066C4FE" modified="2004-10-25" version="1">MGFEQLASLRDQLAKAAAQKRAAKQPQKQPQKHSQKHSQKRDAKPAASPSSTDPVVLTIAKLQKRFPQAFPRNPAPKVPLKVGILEDLVGQASALGLSEAELRDAMRTWCQGNRYWTCLVEGAVRIDLAGGEAGRVSAADAKRARMLKGRRPAKPRAQPSRPEQAAQQQQTSACPPQGAQRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LD3</accession>
    <name>Q63LD3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009897040.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111088.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1076"/>
    <dbReference type="EnsemblBacteria" id="CAH38543">
        <property type="protein sequence ID" value="CAH38543"/>
        <property type="gene ID" value="BPSS1076"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1076"/>
    <dbReference type="eggNOG" id="ENOG502ZENM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="176" mass="19319" checksum="546561D857DCF635" modified="2004-10-25" version="1">MPLCSRRLTMPSKLFLYDANEANKDLLDYFKNKNYTRVALTNSTDFFWSQIDSVDNGGYLAIMSHGNNNTFEIAMGNPPKDMRQDQIVPFGTSLNQRNVTLYLLSCHTGNDPLGRSLLGTGCNFAAPKGYALVKSSSAGVGVYSVVDPHASDVKYAGWTGTEGVIPNRDTKPLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LE5</accession>
    <name>Q63LE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative major capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532901.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111076.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1065"/>
    <dbReference type="EnsemblBacteria" id="CAH38531">
        <property type="protein sequence ID" value="CAH38531"/>
        <property type="gene ID" value="BPSS1065"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1065"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4262"/>
    <dbReference type="eggNOG" id="ENOG502Z7HY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QTNFDTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006441">
        <property type="entry name" value="Phage_P2_GpN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05125">
        <property type="entry name" value="Phage_cap_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01551">
        <property type="entry name" value="major_capsid_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="38018" checksum="19A9C2CBECFE94AD" modified="2004-10-25" version="1">MRKETRQAYEKYAAQIAKLNDTGDVSKKFAVEPTVQQRLETKMQESSEFLKRINVLPVTELEGEKLGLSVSGPIASRTDTTKAARQPIDPTALDSNRYRCEKTDYDTAIPYRKLDMWAKFADFQQRIRDVILNQGALDRIMIGWNGVKAAATTDRQANPLLQDVNIGWLQQYRERAAQRVLHEGAKQAGKVLIGKAGDYENLDALVMDIVSSMIDPWFQEDTGLVVICGRELLHDKYFPIVNATQAPTERLAADLIVSQKRIGNLPAVRVPFFPKRALMVTKLSNLSIYYQEGARRRTLKEVPERDRIENYESSNDAYVVEDFGCGCVAENIELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LF3</accession>
    <name>Q63LF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage gp29 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532793.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111068.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1057"/>
    <dbReference type="EnsemblBacteria" id="CAH38523">
        <property type="protein sequence ID" value="CAH38523"/>
        <property type="gene ID" value="BPSS1057"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1057"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4254"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANHAYTI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="177" mass="18100" checksum="58C27EEEA800881B" modified="2004-10-25" version="1">MGFAFICEGDTTTHGGRVVGCNTANLVYGKAIALLGDMVTCPRCGGIYPIVSVKSGLNMTFGDRPVATDGDKTACGATLIASQGTATVAPTAGQGSPIGGGKSVIAQARSAPNEPYRGRFQLLDDHTREPLANHAYTITSADGRTVHGQTDANGFTSWLDSDEASSLTFTNSGASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LI8</accession>
    <name>Q63LI8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524116.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111033.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1027"/>
    <dbReference type="EnsemblBacteria" id="CAH38488">
        <property type="protein sequence ID" value="CAH38488"/>
        <property type="gene ID" value="BPSS1027"/>
    </dbReference>
    <dbReference type="GeneID" id="56530517"/>
    <dbReference type="KEGG" id="bps:BPSS1027"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4211"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPRAYLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="19031" checksum="9D79C133699D86A0" modified="2004-10-25" version="1">MPANTLRLQREIAALYTGHRGWLHGWLSKKLGCGERAADLVHDTFIRLLARDEPIDAAEPRAFLTTVAQRVLYNHWRRERLERAYLDALAQWPEAVAPSPETRAVLFETLVEVDRMLDGLPAVVRRAFLLAQLDGMTHAQIAAELRVSLATVKRYLVKAGAQCYFAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LP6</accession>
    <name>Q63LP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524062.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110975.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0967"/>
    <dbReference type="EnsemblBacteria" id="CAH38429">
        <property type="protein sequence ID" value="CAH38429"/>
        <property type="gene ID" value="BPSS0967"/>
    </dbReference>
    <dbReference type="GeneID" id="56597333"/>
    <dbReference type="KEGG" id="bps:BPSS0967"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7284"/>
    <dbReference type="eggNOG" id="COG4682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFYAFAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038972">
        <property type="entry name" value="YiaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008024">
        <property type="entry name" value="YiaAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37290">
        <property type="entry name" value="PTHR37290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05360">
        <property type="entry name" value="YiaAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="YiaAB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="YiaAB" evidence="2">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="16122" checksum="7148CD8CA655BEB5" modified="2004-10-25" version="1">MNHHTNQLHPSTSFAFVAASWAALLAGVCAYLLGLWNAGMQLNEKGYYFTVLAYGLFAAVSLQKSVRDRLEGVPVTGLYYGLAWASVILTIALLVIGLFNATLLLSEKGFYAMSFALALFGSVAVQKNTRDLKAAGRGRAETEVAVDIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LR2</accession>
    <name>Q63LR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205488.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110959.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0951"/>
    <dbReference type="EnsemblBacteria" id="CAH38413">
        <property type="protein sequence ID" value="CAH38413"/>
        <property type="gene ID" value="BPSS0951"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0951"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7262"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THHPGRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="16"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="289" mass="30968" checksum="F3B3B07B7250E828" modified="2004-10-25" version="1">MPASSVSPNTPPLAEIEGLRIGFRTHDGALVEAVRDLSLTLAPGERLGIVGESGSGKSLTGRALLGLLPAAAQWHARALRFEGRDLLALGARERRRLCGGAMGMILQDPKYSLNPVMTVATQMAEAFRLREPGLRGRALRERIVDALASVEIRDPARVADAYPHELSGGMGQRVMIAMMVSTGPRLLVADEPTSALDVAVSMQVLAVLDDMIARHRTGLLFISHDLPLVTSFCDRVAVMYAGRVVETCAARDLVHAAHPYTRGLLAATPPLANPPDALPVLERDPAWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LU1</accession>
    <name>Q63LU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939950.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110930.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0921"/>
    <dbReference type="EnsemblBacteria" id="CAH38384">
        <property type="protein sequence ID" value="CAH38384"/>
        <property type="gene ID" value="BPSS0921"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0921"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7220"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PMNAIPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="207"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="472" mass="50801" checksum="A4282E8C812BAD1D" modified="2004-10-25" version="1">MEEPQNTREAAIAAAYQAFDSGAFFADLQRRVAFRTSSQDGVNPALSAYLTDEISATLARLSFTARVVENPVAGGPPFLIAERHESDDLPTVLTYGHGDVVRGYDEQWRVALKPWEIVVDADRWYGRGTADNKGQHSVNFAALAAVLQARDGKLGYNVKVIFETGEEIGSPGLNEVCAAHKLALAADVFIASDGPRVSAERPTLFLGSRGSVPFELTVNLREGGHHSGNWGGVLRNPAVVLSHAIASLIDRDGRIVVEGLRPPPISGAVREALTDIELGRDDSSPDIDPTWGEPGLTPTERVIGWNALEVLAMKSGNADAPVNAIPPFAKAVCQLRFVVGTDWENVQAHLERHFAENGFAQVAVEVARASPATRLDLDDPWVRWALDSMRATTGKKPALLPNLGGTVPNDVFAQTLGLPTLWVPHSYPACGQHAPNEHVLAPVMRESLGMMAGLWWDLGEMGAAIVAARHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LX9</accession>
    <name>Q63LX9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="5">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ribA</name>
        <name evidence="7" type="ordered locus">BPSS0883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195483.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110892.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0883"/>
    <dbReference type="EnsemblBacteria" id="CAH38345">
        <property type="protein sequence ID" value="CAH38345"/>
        <property type="gene ID" value="BPSS0883"/>
    </dbReference>
    <dbReference type="GeneID" id="56597243"/>
    <dbReference type="KEGG" id="bps:BPSS0883"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7175"/>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQGFILY"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="217" mass="23963" checksum="E5C7D0F2AE4F184D" modified="2004-10-25" version="1">MKSSHPDSPQPDDGAAPECVTLVATATLPTRYGTFTSYAFRVAGGDAEHLALVMGDVAEQPSVLTRLHSECLTGDVFGSYRCDCGEQLDLSLRYIAAEGRGVLLYLRGHEGRGIGLSNKIRAYALQEQGRDTVEANLDLGLPDDAREYDSAAAILRILKVTSVRLMSNNPKKFDTLARHGIPVCERVALAVPVREENERYIRTKQLKFGHYYFDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M59</accession>
    <name>Q63M59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative extracellular ligand binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200893.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110812.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0802"/>
    <dbReference type="EnsemblBacteria" id="CAH38263">
        <property type="protein sequence ID" value="CAH38263"/>
        <property type="gene ID" value="BPSS0802"/>
    </dbReference>
    <dbReference type="GeneID" id="56597123"/>
    <dbReference type="KEGG" id="bps:BPSS0802"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7064"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KYIFRFV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266581" evidence="3">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="31"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="380" mass="39922" checksum="A9FC9049062887A3" modified="2004-10-25" version="1">MKRKINRLLPISAAAMVMAAASTHALADQVVKIGSAEPLTGGIAHLGKDNENGARLAVEEINAKGLTIGGQKVTLQLDAQDDAADPRTATQVAQKLVDGKVVAVIGHLNSGTSIPASKIYSDAGILQISPSATNPAYTQQGFKTTYRVVATDAQQGPALADYAKQKGIKTVAVVDDSTAYGQGLANEFEKKAKALGLKVVSHDATNDKAVDFRAILTKIKGTNPDAIMYGGMDATGGPFAKQAKQLGLRAKIFAGDGVCTEQLPALAGNAAENVVCSQAGAALEKMPGGATFQAKYEKRFNQPIRFDAPFTYDAVYIIVDAMKRANSTDPAKILAVMPKTNYTGVIGTTVFDSKGDLKHGVISLYDFKGGKKTFLDQVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MD3</accession>
    <name>Q63MD3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523806.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110738.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0725"/>
    <dbReference type="EnsemblBacteria" id="CAH38185">
        <property type="protein sequence ID" value="CAH38185"/>
        <property type="gene ID" value="BPSS0725"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0725"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6951"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NMVVYVC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="27532" checksum="FDC071E46FC452ED" modified="2004-10-25" version="1">MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHAQGVVADLSDADGARRVIDAAPSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRLARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTAQLSISRGLAKLAAGSRVTVNAVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYVCSPQASATTGAALRVDGGVVDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MH8</accession>
    <name>Q63MH8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523768.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110693.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0680"/>
    <dbReference type="EnsemblBacteria" id="CAH38139">
        <property type="protein sequence ID" value="CAH38139"/>
        <property type="gene ID" value="BPSS0680"/>
    </dbReference>
    <dbReference type="GeneID" id="56530870"/>
    <dbReference type="KEGG" id="bps:BPSS0680"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6891"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IIHYLTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="15895" checksum="87232836410F9070" modified="2004-10-25" version="1">MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCVLPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTDADIDAAMNGNICRCATYTRIRAAIHEAAATLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ3</accession>
    <name>Q63MQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530094.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110618.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38054">
        <property type="protein sequence ID" value="CAH38054"/>
        <property type="gene ID" value="BPSS0597"/>
    </dbReference>
    <dbReference type="GeneID" id="56530951"/>
    <dbReference type="KEGG" id="bps:BPSS0597"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6774"/>
    <dbReference type="eggNOG" id="ENOG502ZVXQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LNIWPTD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021347">
        <property type="entry name" value="DUF2964"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11177">
        <property type="entry name" value="DUF2964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="64" mass="6727" checksum="1D72280D12A5718D" modified="2004-10-25" version="1">MVRTELRVVLAAIATFVMLAGIAVAIHGSLFDQDAALRYGAAAIALGVTTCAIALNVWPKDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ8</accession>
    <name>Q63MQ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530088.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110613.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0592"/>
    <dbReference type="EnsemblBacteria" id="CAH38049">
        <property type="protein sequence ID" value="CAH38049"/>
        <property type="gene ID" value="BPSS0592"/>
    </dbReference>
    <dbReference type="GeneID" id="56530956"/>
    <dbReference type="KEGG" id="bps:BPSS0592"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6768"/>
    <dbReference type="eggNOG" id="ENOG5032PEQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="88" mass="8971" checksum="0C1A5343C494C2D8" modified="2004-10-25" version="1">MAGGWPARAAVATGGAALGAAELAVTLARHYPADGLNRLYAAVLVALAAGVAVLLWALVARDGRQAAWRACAWLAVLTPCVWLCAGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N75</accession>
    <name>Q63N75_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4,6-dehydratase (O-antigen-related)</fullName>
            <ecNumber evidence="2">4.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbG</name>
        <name evidence="2" type="ordered locus">BPSS0420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.45" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110444.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0420"/>
    <dbReference type="EnsemblBacteria" id="CAH37876">
        <property type="protein sequence ID" value="CAH37876"/>
        <property type="gene ID" value="BPSS0420"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0420"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6556"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CYENREW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047733">
        <property type="term" value="F:CDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05252">
        <property type="entry name" value="CDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="357" mass="39634" checksum="C93860A268E9AC55" modified="2004-10-25" version="1">MHAPDARFWQARRVLVTGHTGFKGSWLSLWLQSLGAQVHGLALEPPSRPSLFETARVAQRMSSTIGDIRDYDVVRRTIADCRPEVVIHLAAQPLVRASYADPLSTYGTNVMGTANLLEALRRAGCARAVVNVTTDKCYENRDWLWGYRENDVLGGHDPYSSSKACSELVSSAYRRSFFAQGATALASARAGNVIGGGDWAAERLVPDVLAAFASGRPAVIRHPHAVRPWQHVLDSLSGYLRLAERLHADGQAWAEAWNFGPDDAQARTVEWVVSRMARIWGGDARWHPDSADHPHEAAQLKLDSSKAKARLGWRPRWSLARALECTIAWHRAWLAREDMRAVCIEQIAEFDTSPDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NH2</accession>
    <name>Q63NH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport-related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531457.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110347.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0327"/>
    <dbReference type="EnsemblBacteria" id="CAH37775">
        <property type="protein sequence ID" value="CAH37775"/>
        <property type="gene ID" value="BPSS0327"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0327"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6444"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLNRQDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="45502" checksum="CF1DC7C962ED8CA2" modified="2004-10-25" version="1">MPASELSAVSSAPPRALTGRDYKTLGLAALGGALEFYDFIIFVFFAPAIGQLFFPHDIPDWLRQLQTFGIFAAGYLARPLGGIVMAHFGDLIGRKRMFTLSVLLMSVPTLLMGLLPTYDSVGILAPVVLLLLRVLQGAAVGGEVPGAWVFVSEHVPPQRIGYACGTLTAGLTIGILLGSLVATAVNSRFSTAEVAAFAWRIPFLLGGVFGLFSVYLRRWLHETPVFAEMKARKTLAAEIPLKAVIRDHGRAVIVSMLITWMLSAAIVVVILMTPTLLQKQFHIAPATALFANSIATLCLTAGCITAGSLADRFGAKAVLSIGGVALAACYYAMYTQIAVDAARLVPLYGLAGFTVGTIGAVPFVLVKSFPAVVRFSGISFSYNVAYAVFGGLTPVIVSLLMKSHSLAPAHYVAAICVLGAVAMLFSKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NR2</accession>
    <name>Q63NR2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">BPSS0238</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110257.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0238"/>
    <dbReference type="EnsemblBacteria" id="CAH37684">
        <property type="protein sequence ID" value="CAH37684"/>
        <property type="gene ID" value="BPSS0238"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0238"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4202"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQLTSMM"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="19">
        <location>
            <begin position="86"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="18">
        <location>
            <begin position="352"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAH37684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="720" mass="76877" checksum="CB95971151D9969F" modified="2004-10-25" version="1">MPTKDFDMTDHTPHSSPPASPTPPQGPAPKRRRYFRTLAGLVLGAAIAGGAVGTWTLHRIWTALPSVEPLAVYRPALPLRIFSREGELLAEYGVERREFVPLDRIPPLVRHALLAAEDAQFYTHGVVDIGGLARATVANVVTGQPGQGGSTITMQVARNFFLTREKVLSRKLAEILMSYKLERAYSKDKLLELYMNEIYLGERAYGFAAAASVYFGKPLDALTPGEAAVLAGLPKAPSAFNPVVNPARATMRRNYVLGRMRALGYLDEAAYRQAADAPIALATTPPPGILAAPYVAERARRMMVERFHDDAYTLGLDVTTTIAMREQRAADAALARGLAQVGRRDAKDALEGALVSIDAATGDILALVGGADFSHNVFDHALQAYRQPGSSFKPFVYSAALEKGMFPGVLIDDTQRTLSRDETGANPWRPRNFGNHYEGFIPVRRGLMRSKNLVAVSLMQVARPDFVQQHAARFGFEPLRNPASLPLALGAGSATPLEVASAYGVFANGGVRMEPRLIESVRQRHGGALFDAQPAPGVRVISARNAFVMDSMLRDVVAHGTARRAVALKRADAAGKTGTSNGSKDVWFAGYSSGVVSVVWMGYDAPRSLGRATGSSAALPVWVDYMKTAVDGRGAIERTPPADVALVDGDFVYAEYANGDKCAPSLPPFVRSPFACGAARGAPADGGAPASAAGAAGAPTPAAVDAAERARVLELFRTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NW9</accession>
    <name>Q63NW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110200.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0179"/>
    <dbReference type="EnsemblBacteria" id="CAH37624">
        <property type="protein sequence ID" value="CAH37624"/>
        <property type="gene ID" value="BPSS0179"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0179"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4120"/>
    <dbReference type="eggNOG" id="COG3520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRLIAQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03347">
        <property type="entry name" value="VI_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="357" mass="39724" checksum="06FA12CC3A75730F" modified="2004-10-25" version="1">MTQAAVADTALSPQALARLRAEPWRYGFLALLRRIGADARIDPIGKARRPQAEPFRLGQQPSLAFAPREIASVGDANGRLKVRLFGLGMLGPNGPLPIHVTEIARDREESRRDPTLGNFLDIFHHRYLTLLYRAWASAQAVAGLDRPDDERFSFYVASLAGQDLDEVGAQPLPAHARLSASPHLVREARNADGLRMTLERYFGVPVTLEENVFHWIAVDPLEHSRLGRPGDASTMAAGALLGELVPDRQHKFRLVFGPLDIDAYLRFTPRGEDLPRLVEWVRAFVGYEFEWELELRIKPNGAPPAVMGGPHQLGWSGWLGRSPSGEPVTGMRFEPEHYAHGFARGTARDTRGMRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ9</accession>
    <name>Q63NZ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523584.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110170.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0149"/>
    <dbReference type="EnsemblBacteria" id="CAH37594">
        <property type="protein sequence ID" value="CAH37594"/>
        <property type="gene ID" value="BPSS0149"/>
    </dbReference>
    <dbReference type="GeneID" id="56531401"/>
    <dbReference type="KEGG" id="bps:BPSS0149"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6199"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VSMWSDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="32239" checksum="427302F88B4094AA" modified="2004-10-25" version="1">MKYHQLKAFVAVADEGSIRAAARRLNVSPAALTKAVKELELALGVSLVVRTARGVQLTRFGQQLQVRASLIVAEMQRARDDIEQAQGATTGAVAAAITPAAAVTILPDAFRAFRRRFPLARVSIVEGFPGVALPKLHDGSLDFAVSVVVPELLAAEFEHAQLYASRHVIVARNAHPLAAATSLADLVDADWLMNPSPESSTQLMFNCFAEHGLPAPTRVVECPSYAIAHSLIQGSDLIASMPEQLLGVEWSRDRIAVLPIREALPAASVQVVTRRDSPLTPAAAMLVDCMRDAARRHGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P62</accession>
    <name>Q63P62_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009922878.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110107.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37529">
        <property type="protein sequence ID" value="CAH37529"/>
        <property type="gene ID" value="BPSS0083"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0083"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6103"/>
    <dbReference type="eggNOG" id="ENOG5032W6D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGEACFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266502" evidence="1">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="230" mass="23269" checksum="CF4BE1570D9677F2" modified="2004-10-25" version="1">MNSQHARFIRPVLGTLCIVSLAALSGCRGDACFGFDGCFDDGGVQTVTLSGTAATGPALASATVNVDCARGSVATLSDGGGHYSVTFDAALPCAITVTSGGTSLHSLAYAGGTFNTTPQTELLLVYLAAQLGTSPVRLIGDLPNSSRLQQALENQTNVQAAQTAVVTHLQQRYAVMFAVPGFLTTPFFVGQPGVDSDLGALANAGAIDANGMPDALAVSLLQQAGAAHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P93</accession>
    <name>Q63P93_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201060.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110076.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0052"/>
    <dbReference type="EnsemblBacteria" id="CAH37495">
        <property type="protein sequence ID" value="CAH37495"/>
        <property type="gene ID" value="BPSS0052"/>
    </dbReference>
    <dbReference type="GeneID" id="56596801"/>
    <dbReference type="KEGG" id="bps:BPSS0052"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6055"/>
    <dbReference type="eggNOG" id="COG4275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDRVACP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018634">
        <property type="entry name" value="Chromate_resist"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09828">
        <property type="entry name" value="Chrome_Resist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="142" mass="16011" checksum="4C2287D8312833CD" modified="2004-10-25" version="1">MKWITRERPKIDRIACPWLIARFVDKAAEFLYVPDADVLRIAKETGAIPFDVPDVELGHHGELCSFDAFLEKYALHDPALLKLAAIVRGADTGRYDLAPEASGLHAISVGLSGNFRDDLEQLRHGMVMYDALYAWCRRDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PE9</accession>
    <name>Q63PE9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor protein QseC</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL3427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551113.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110020.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3427"/>
    <dbReference type="EnsemblBacteria" id="CAH37439">
        <property type="protein sequence ID" value="CAH37439"/>
        <property type="gene ID" value="BPSL3427"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3427"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1757"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDTGAEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013727">
        <property type="entry name" value="2CSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08521">
        <property type="entry name" value="2CSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="246"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH37439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="494" mass="53247" checksum="455FB1E962748746" modified="2004-10-25" version="1">MSPDPAVTSLRRTLLRRLAAPLSMLALMSGLIAYWLAWQYTQHVVDRSLADLASAISKQIQIAGPDAPFTVPPLAQAMFSDPTEQLIYRISDGEHELAGDPKLPLQGTSVRRMHVAYVFEAEYDNQAVRVAQVRVAQTESGNPMIVEVAQPVRYRYRIAAEFLIAIMMPLLLLLLAGWGIVWRVVNQQLGPLTHLADSLNRQTHTSLEPVDETEVPLEIRPLTSAMNALLGRLKTALDAQRKFIADAAHQLRTPLTAIKLHAEQAAVARDPQQALTAVRELRSAADRAVRLSNQLLSLARAEPGEQAARFVDVDLAALAFETGAEWVPRALAAHVDLGFQRGDGRGDDEPLLVRGNPVLLREVIANLLDNALKYVPLARPQGARITMDVSRIALDEGHAAAEIVVEDNGSGVPAAQQADLFKRFFRGDAQSGNGVETGAGLGLAIVHDIIAMHGGTVSYADAPEGGSCFIVRVPLADTPSTPAPPPCESPAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PG5</accession>
    <name>Q63PG5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195812.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110004.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3411"/>
    <dbReference type="EnsemblBacteria" id="CAH37423">
        <property type="protein sequence ID" value="CAH37423"/>
        <property type="gene ID" value="BPSL3411"/>
    </dbReference>
    <dbReference type="GeneID" id="56593911"/>
    <dbReference type="KEGG" id="bps:BPSL3411"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1778"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TTLYYDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="36991" checksum="852D1C33B300D538" modified="2004-10-25" version="1">MDFSIAAILAQDGITTGAIYALLSLALVLVFSVTRVIFIPQGEFVTYGALTLAALQAQKFPATCWLLFVAGIACFMLEVGGLIRHRARRRRLARTLTTLASRYVLLPLAIYAVTRSAAAQPLPMIAQIALTLAIVVPLGPFIYRLAYQPIAEGTTLLLLIVSVAVHFALVGLGLVMFGAEGSRTTAFSDTSLALGSLSISMQSAWVVGTALVLIAALYLYFERTLPGKALRATSVNRLGARLVGIGTTEAGRLAFTLAAGLGALSGVLVGPLTTIYYDSGFLIGLKGFVGAIIGGLVSYPLAAAGSLLVGVLESYSSFWASAYKEVIVFTLIVPVLLWRSLAAPQTEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI6</accession>
    <name>Q63PI6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">priA</name>
        <name evidence="11" type="ordered locus">BPSL3390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205311.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109983.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3390"/>
    <dbReference type="EnsemblBacteria" id="CAH37402">
        <property type="protein sequence ID" value="CAH37402"/>
        <property type="gene ID" value="BPSL3390"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3390"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1802"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="224"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="755" mass="81909" checksum="39B2E9F9B386CF8E" modified="2004-10-25" version="1">MADAFVRVVLDHPLPTLFDYRYRGDMPAAPGMLVQVPFGRRSVVGLVCEVTAHTDVPAAKLKAVDAVCTELPPLSRHWLELAAFAADYYQRGLGEVALPALPQALRDVPRWGRLLAPELRYRLLDAGRAALPDALPARGAALRRLAQALADAPALSLAEVRALHPKAVAVLDEWQAQGWAACDEIAITHADAQLVDNPAPASARRPTALPPQLTDQQAEALDAIAAADGFAPFLLHGVTGSGKTEVYLRALAALLERRPEAQALVLVPEINLTPQFEAAFRARFAATLPADAIVTLHSGLAEGERARHWLAAHTGRARIVLGTRLAVLASLPALAMIVVDEEHEPAYKQQEGLRYSARDLAVWRAKQLAIPVVLGSATPSLETWWQAEQGRYRRLTLTKRAVADAALPTVRLVDLEEERRRGRGSMGGLSGPLVAALKARLERGEQSLVFLNRRGYAPALACDACGWVAGCPRCSAYVVMHKPEHAVRCHHCGWEARIPRACPECGNVDIAPLGRGTQRVEETLALAVPGARILRIDADSTRRKGSAQALFSDVHAGEVDILVGTQMIAKGHDFQRVSLVGVLNADTALFSHDFRASERLFAQLMQVSGRAGRAGLPGEVLIQTRYPRHALYHALARQDYVGFAGATLGERRDAHLPPFVYQALLRAEGRTLDAALAFLQQAADAFSGLPGAERVTVYDAVPMTIVKVANVHRAQLLIESASRAALQHTLRAWQPLLRELKGVLRWSVEVDPLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM6</accession>
    <name>Q63PM6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage-related lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205301.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109943.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3347"/>
    <dbReference type="EnsemblBacteria" id="CAH37360">
        <property type="protein sequence ID" value="CAH37360"/>
        <property type="gene ID" value="BPSL3347"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3347"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1857"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVYEVAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266226" evidence="2">
        <location>
            <begin position="21"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="458" mass="48991" checksum="21FCBF3380F78B7C" modified="2004-10-25" version="1">MRRYCGLIVALMLSSGCRIAAGAVPPLPTLPVDATIGTSPAIQIPAAPVSTPLKHVPGTAFDLRFVTVAQVVDLIYQDAMHTPYVLGPDVLADNRLVSFRLDDAVRDVRAVMVDFLDSLGFRVTTKNGVDYVARKAADSRARVDQEVFVYRPRYRSAESLRSLVEPVIGTRSMIPMSAIAATPSAVTSPVQVPGAPISTASDVAVAPAAAGVQARGNELVIVGSRDEVAMLRKLVPDLDTAPGEVVVRGWVYEVANTDSANSAWSIAVRLLSGQLRLSSGDTSSDASAMRFTGPGVDAAISALNADSRFKVVSSPHVRIVSGERVRLNVGQQVPTQSSVSYQGSSGTPVQSITYQDAGLIFDVEPTVMRDVIELKVREEISDFVATKTGVDTSPTKNTRQLQTVTRLKDGELVVLGGLIQDRDATARSGYSWLPSFFDGRSSSKQRTEVLLVLQVQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM8</accession>
    <name>Q63PM8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205299.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109941.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3345"/>
    <dbReference type="EnsemblBacteria" id="CAH37358">
        <property type="protein sequence ID" value="CAH37358"/>
        <property type="gene ID" value="BPSL3345"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3345"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1860"/>
    <dbReference type="eggNOG" id="ENOG5032QU2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLRCKAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="29813" checksum="C7A0B43296554039" modified="2004-10-25" version="1">MHDASIGDFSPFRREWVIRGRNFGDGQVEVTATRFDRYMGALSLNARPKAKRGESENSESNLLDAAKRAKQQVRLRCKAIGADRMITLTYRENMQDKARLKRDFDALRRRLAKLSTFQYVATPERQKRGAWHLHVAVRGRQNYRVLRSIWQSIVGVGNGQINVRNPFKERGLRHKLAAYLAKYITKDFAEHALNEKRYWTSRGVVVPEVMPIDHIAANDPAEALKIAFKAALQAGATLDRCQAFWRQELGVFWLSTREN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q28</accession>
    <name>RS5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">BPSL3196</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197945.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109790.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q28"/>
    <dbReference type="SMR" id="Q63Q28"/>
    <dbReference type="STRING" id="272560.BPSL3196"/>
    <dbReference type="EnsemblBacteria" id="CAH37207">
        <property type="protein sequence ID" value="CAH37207"/>
        <property type="gene ID" value="BPSL3196"/>
    </dbReference>
    <dbReference type="GeneID" id="56594560"/>
    <dbReference type="GeneID" id="64462482"/>
    <dbReference type="GeneID" id="66525193"/>
    <dbReference type="KEGG" id="bps:BPSL3196"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2042"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="PRO" id="PR:Q63Q28"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131490" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="172" mass="18150" checksum="FDF5C63E7B16365C" modified="2004-10-25" version="1">MAKMQAKVQADERDDGLREKMISVNRVTKVVKGGRILGFAALTVVGDGDGRVGMGKGKAKEVPVAVQKAMEQARRNMFKVPLKNGTLQHEVHGKHGASTVLLAPAKDGTGVIAGGPMRAVFDVMGVQNVVAKSHGSTNPYNLVRATLDGLRKQSTPADIAAKRGKSVEEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q61</accession>
    <name>Q63Q61_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">sn-glycerol-3-phosphate transport system permease protein UgpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpE</name>
        <name evidence="9" type="ordered locus">BPSL3164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550999.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109757.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3164"/>
    <dbReference type="EnsemblBacteria" id="CAH37174">
        <property type="protein sequence ID" value="CAH37174"/>
        <property type="gene ID" value="BPSL3164"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3164"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2075"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IAFFIAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015794">
        <property type="term" value="P:glycerol-3-phosphate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030165">
        <property type="entry name" value="UgpE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43744:SF8">
        <property type="entry name" value="PTHR43744:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="77"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="30801" checksum="562D1F2CCB950F7E" modified="2004-10-25" version="1">MIENRKGFDLFCHAVLIAGIAVIVFPVYVGFCAATMNAREVFTVPLSLVPSTHLFENVTAIWRRGSGGMTTPFGTLLVNSVVMALVIAAGKISASILSAYAIVYFRFPLRNTAFWLIFVTLMLPVEVRIFPTVQVVSTLHLTNSYAGLTLPLIASATATFLFRQFFMTLPDELVDAARIDGAGPLRFFWDVVLPLSKTSIAALFVITFIYGWNQYLWPILITTDASLTTAVVGIKSMIASGDAATEWHLVMAATLVAMLPPLVVVLAMQRWFVRGLVDSEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QG7</accession>
    <name>AZOR_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN-dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="1">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="1">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">azoR</name>
        <name type="ordered locus">BPSL3056</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="1"/>
    <dbReference type="EC" id="1.7.1.17" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549943.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109651.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QG7"/>
    <dbReference type="SMR" id="Q63QG7"/>
    <dbReference type="STRING" id="272560.BPSL3056"/>
    <dbReference type="EnsemblBacteria" id="CAH37067">
        <property type="protein sequence ID" value="CAH37067"/>
        <property type="gene ID" value="BPSL3056"/>
    </dbReference>
    <dbReference type="GeneID" id="56597084"/>
    <dbReference type="KEGG" id="bps:BPSL3056"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2209"/>
    <dbReference type="eggNOG" id="COG1182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGITFKY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000245899" description="FMN-dependent NADH:quinone oxidoreductase">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <sequence length="198" mass="20862" checksum="5E0E5A20F07A4E17" modified="2004-10-25" version="1">MTTILQINSAARSQGAQSTLLADELTAKLQQGNPGATVKVRNLLADALPHLDDAVLGAFFTPADQRSAEQNAIVAKSDELVDELRSADVIVIGAPMYNFGVSSQLKAYFDWIARAGVTFRYTSEGPEGLIKGKKAYVVSARGGKHVGMPTDSQTPFLKTFLGFIGLTDVTFVYAEGLALGPDAATEALASAREAIAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QG8</accession>
    <name>Q63QG8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ung</name>
        <name evidence="12" type="ordered locus">BPSL3055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109650.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3055"/>
    <dbReference type="EnsemblBacteria" id="CAH37066">
        <property type="protein sequence ID" value="CAH37066"/>
        <property type="gene ID" value="BPSL3055"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3055"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3487"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH37066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="27095" checksum="2272E808ACDACD7F" modified="2004-10-25" version="1">MQGGASALTLESQFDALPPDWRAIVEPFVASDAYAPLCRFVDGERAAGKAIYPADVFRALRLTHPDDVKVVILGQDPYHGEDRGIPQAHGLAFSVPPGVRPPPSLRNIFKEISADFGYETPRHGCLDTWARQGVLLLNTVLTVERAAAASHAKRGWEKCTDTLIHELATRHRHLVFMLWGAHAQAKRALFDAREHCVLEAPHPSPLSAHRGFLGCRHFALANDYLVQHGRAPIDWRLPDEAETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QQ6</accession>
    <name>Q63QQ6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-arabinose-binding periplasmic protein</fullName>
            <shortName evidence="1">ABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522055.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109562.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2968"/>
    <dbReference type="EnsemblBacteria" id="CAH36978">
        <property type="protein sequence ID" value="CAH36978"/>
        <property type="gene ID" value="BPSL2968"/>
    </dbReference>
    <dbReference type="GeneID" id="56528228"/>
    <dbReference type="KEGG" id="bps:BPSL2968"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2307"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWKFADQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042882">
        <property type="term" value="P:L-arabinose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01540">
        <property type="entry name" value="PBP1_arabinose_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026266">
        <property type="entry name" value="AraF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002816">
        <property type="entry name" value="AraF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005153710" description="L-arabinose-binding periplasmic protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_1" evidence="3">
        <location>
            <begin position="29"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="site" description="The binding site for the sugar molecule has not yet been established, but C-87 may be involved" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="331" mass="34937" checksum="92B0C7723C20CFDC" modified="2004-10-25" version="1">MKRRTFITLAAAATVAAAGLPAQAAEPVKIGFLVKQPEEPWFQDEWKFAELAAKDKGFTLVKIGAPSGEKVMSAIDNLAAQKAQGFIICTPDVKLGPGIVAKAKSHGLKMMTVDDRLVDGAGKPIESVPHMGISAYDIGKQVGGGIAAEIKRRGWNMNEVGAIDITYEQLPTAHDRTTGATDALVAAGFPKANVIAAPQAKTDTENAFNAANIALTKNPKFKHWVAYGLNDEAVLGAVRAAEGRGFKAADMIGIGIGGSDSALSEFKKPQPTGFFGTVIISPKRHGEETSELMYAWITQGKAPPPLTLTTGMLATRENVAQVRETMGLAAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QQ7</accession>
    <name>ARAG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arabinose import ATP-binding protein AraG</fullName>
            <ecNumber evidence="1">7.5.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">araG</name>
        <name type="ordered locus">BPSL2967</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30007"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17535"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (AraG), two transmembrane proteins (AraH) and a solute-binding protein (AraF).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH36977" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.5.2.12" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36977.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938735.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109561.2">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QQ7"/>
    <dbReference type="SMR" id="Q63QQ7"/>
    <dbReference type="STRING" id="272560.BPSL2967"/>
    <dbReference type="EnsemblBacteria" id="CAH36977">
        <property type="protein sequence ID" value="CAH36977"/>
        <property type="gene ID" value="BPSL2967"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2967"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2308"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVHLGHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015612">
        <property type="term" value="F:ABC-type L-arabinose transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042882">
        <property type="term" value="P:L-arabinose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017917">
        <property type="entry name" value="ABC_transptr_Ara_ATP-bd_AraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF6">
        <property type="entry name" value="PTHR43790:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51268">
        <property type="entry name" value="ARAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000270458" description="Arabinose import ATP-binding protein AraG">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="253"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="503" mass="54965" checksum="3A8A5AEB6C993F53" modified="2007-01-09" version="2">MAAALRFDNIGKVFPGVRALDGISFDVQAGQVHGLMGENGAGKSTLLKILGGEYQPDSGSVLVDGRAMRFPSAAASIAAGVAVIHQELQYVPDLTVAENLLLGRLPSALGWVRKRDAQRFVRERLAAMGVDLDAQAKLRRLSIAQRQMVEICKALLRNARVIALDEPTSSLSHRETEVLFKLVDDLRRDGRALIYISHRMDEIYRLCDACTIFRDGRQVASHASLANVPRETLVRQMVGREISDIYHYAPRALGDVRLSARALEGDALRAGASFDVRAGEIVGFFGLVGAGRSELMRVIYGAQRRTGGALTLDGEPLDIRSTRDAIRRGIVLCPEDRKEEGIVAHASVAENINISCRRHGLRAGLFLDRKREAETADRFIKLLKIKTPNRRQKIRFLSGGNQQKAILARWLAEPDLKVVILDEPTRGIDVGAKHEIYGVIYELAKRGCAIVMVSSELPEVLGVSDRIVVMSEGRIAGELARGEANEEAVLNLALPQGATAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QT4</accession>
    <name>Q63QT4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194134.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109534.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2940"/>
    <dbReference type="EnsemblBacteria" id="CAH36950">
        <property type="protein sequence ID" value="CAH36950"/>
        <property type="gene ID" value="BPSL2940"/>
    </dbReference>
    <dbReference type="GeneID" id="56593778"/>
    <dbReference type="KEGG" id="bps:BPSL2940"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2340"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDLEHSW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="103"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="235" mass="24623" checksum="D83A8E7C759BFEB0" modified="2004-10-25" version="1">MATPTGILHYLASGDAVTHAVAYVLLAMSIASWCFLLVKAWVLVRAKRQGPAALAAFWRAATLDDGIAALRAADKERVFAPLAEAAREADAASRVEPHALAARVERGERVLRALRHALRASQRRLEFGQVLLASIGSTAPFVGLLGTVWGIYHALGSIAASGQAQIENVAGPVGEALIMTAFGLVVAIPAVLAYNILGRLVRQLVEELDGFARDLHVFVCGEPAAAAADDAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV1</accession>
    <name>Q63QV1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate/aspartate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltJ</name>
        <name evidence="9" type="ordered locus">BPSL2923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194293.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109517.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2923"/>
    <dbReference type="EnsemblBacteria" id="CAH36933">
        <property type="protein sequence ID" value="CAH36933"/>
        <property type="gene ID" value="BPSL2923"/>
    </dbReference>
    <dbReference type="GeneID" id="56593760"/>
    <dbReference type="KEGG" id="bps:BPSL2923"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2360"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QLVPMWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030202">
        <property type="entry name" value="GltJ/AatQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614:SF42">
        <property type="entry name" value="PTHR30614:SF42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="30"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="246" mass="27400" checksum="A154C1CBD37060D0" modified="2004-10-25" version="1">MSYHWNWGIFLSPVSTGEPTTYLGWLMSGFWVTVKVSLVAWVIALVVGSLFGVLRTVPNKWLSAIGTVYVSIFRNIPLIVQFFVWYLVVPELLPVSIGTWIKQLPPGTQFFTASIVCLGLFTGARVCEQVRSGINALPKGQRAAGLAMGFTQWQTYRYVLLPVAYRIIVPPLTSEFLNIFKNSAVASTIGLLDLSAQARQLVDYTAQTYESFIAVTLAYVVINLIVMTFMRWVESKSRLPGYIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R36</accession>
    <name>Q63R36_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DNA gyrase control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tldD</name>
        <name evidence="6" type="ordered locus">BPSL2838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194084.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109432.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2838"/>
    <dbReference type="EnsemblBacteria" id="CAH36848">
        <property type="protein sequence ID" value="CAH36848"/>
        <property type="gene ID" value="BPSL2838"/>
    </dbReference>
    <dbReference type="GeneID" id="56594673"/>
    <dbReference type="KEGG" id="bps:BPSL2838"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2464"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="146"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="262"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="498" mass="52685" checksum="1DF2A9100A671701" modified="2004-10-25" version="1">MNIIEPGIPQGDFLQGARNLSLAKDILLTPYGLDEALLTRTLADIFTHRVDYADLYFQATRSEAWSLEEGIVKSGSFSIDQGVGVRAVAGERTAFAYSDDLSPEAIRQAAVATKAIAAAGGGKQKIRAATALKGVSGRDLYLPADPLASLDATAKVKLLERVEQMARGRDPRIKQVMAGLAGEYDVVLVARSDGALAADIRPLVRVSVTVIAEHNGRREIGTGGGGGRFDYGYFTDDVLARYVDDAVHAALVNLDARPAPAGAMTVVLGPGWPGVLLHEAIGHGLEGDFNRKGSSAFAGRIGEQVAAKGVTVVDDGTLPNRRGSLNIDDEGNPTQCTTLIEDGILKGYIQDTLNARLMKMPVTGNARRESYAALPMPRMTNTYMLNGDKDPREIIESVKHGLYAVNFGGGQVDITNGKFVFSASEAYMIENGKVTYPVKGATLIGSGPESLKYVSMIGNDMRLDTGVGVCGKEGQSVPVGVGQPTLRLDNMTVGGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R97</accession>
    <name>Q63R97_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205219.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109371.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2776"/>
    <dbReference type="EnsemblBacteria" id="CAH36785">
        <property type="protein sequence ID" value="CAH36785"/>
        <property type="gene ID" value="BPSL2776"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2776"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2537"/>
    <dbReference type="eggNOG" id="COG3562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MWNGQQL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015774">
        <property type="term" value="P:polysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007833">
        <property type="entry name" value="Capsule_polysaccharide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05159">
        <property type="entry name" value="Capsule_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="398" mass="44150" checksum="B4941512C20B39AA" modified="2004-10-25" version="1">MIVVVVDSMERYYFAVRLVKAVRKEFDFLFAASEPLAHLMALAAGFRSVYLRRGAHAPAMLDAAAGIRSDASIEVLNGQMTPERARADAQAVFAAMSGVFRRHLVSQCLMWNGQQLVCRAVAHACATHGVPTKFVEISNLPDKLFVDRLGVNALSSISRNPAVIDGLPMPTEGEHRRWFARYEAYKARPLPQSRTSWARKAMSAANYALKLATQGVARKRLDAARATNGARAPAQAKVLSTKELSALRYVFLPLQVSGDTQIKLHSDVDNLKAIRLAFEHAANENADLIVKLHPAERDVAVIDEVVRMQRVYHFDLVTSPTTDLIKHAHSVVTINSTVGLEALLYGKPVVSLGRCFYKEFDRARLLKYIHAFLIDGIDYFGRADIAPRAARNVFSMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RA6</accession>
    <name>Q63RA6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division coordinator CpoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpoB</name>
        <name evidence="4" type="ordered locus">BPSL2766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CpoB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186614.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109362.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2766"/>
    <dbReference type="EnsemblBacteria" id="CAH36774">
        <property type="protein sequence ID" value="CAH36774"/>
        <property type="gene ID" value="BPSL2766"/>
    </dbReference>
    <dbReference type="GeneID" id="56594907"/>
    <dbReference type="KEGG" id="bps:BPSL2766"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2549"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWLGEVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070206">
        <property type="term" value="P:protein trimerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032519">
        <property type="entry name" value="YbgF_tri"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16331">
        <property type="entry name" value="TolA_bind_tri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009992591" description="Cell division coordinator CpoB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="TolA_bind_tri" evidence="3">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="2">
        <location>
            <begin position="128"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="249" mass="27396" checksum="0268DBCC99E6475A" modified="2004-10-25" version="1" precursor="true">MTHRFPWLRTAAALCVAGAALLAAPAHAGLFDDDEARRAVLDLRSKSDSQASQLAAAQRTILDQTNRLDQLNQQVATLRGENEDLTNRLTTLERQQKEYYTDLDTRLKKFEPQKTTVDGVEGTVQPGETDAFNAASQQFRNGNFKGAAASFRAFIAKYPQSPYQPTAQYWLGNAQYALRDYKGSTATWQGLVKNYPQHPRAADALIAIGTNQLEQGQKAAAKKTFEQVVSQFPGSNAAETAQSKLDAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RD2</accession>
    <name>Q63RD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxybenzoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pcaK</name>
        <name evidence="7" type="ordered locus">BPSL2740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109336.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2740"/>
    <dbReference type="EnsemblBacteria" id="CAH36748">
        <property type="protein sequence ID" value="CAH36748"/>
        <property type="gene ID" value="BPSL2740"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2740"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2580"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KYSRMIS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="451" mass="46896" checksum="D6B193C44F5EBFFA" modified="2004-10-25" version="1">MSAAANPARVLEIERVIDDTHRPAFHAMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVKKQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGATLFFALAMLATPFATSIPILIALRFVTGLGLGCIMPNAMALVGECSPSAHRVKRMMIVSCGFTLGAALGGFVSAALIPAFGWRAVFFVGGAVPLALAAAMAASLPESPQLLVLRGRHDAARAWLAKFAPRLAVPPDTRLVVREAGPRGAPVAELFRSGRARVTLLLWAINFMNLIDLYFLSNWLPTVMRDAGYASGTAVIVGTVLQTGGVIGTLSLGWFIERHGFARVLFACFACATIAIGLIGSVAHAFVWLLAAVFVGGFCVVGGQPAVNALAGHYYPTSLRSMGIGWSLGVGRVGSVLGPLVGGQLIALGWSNDALFHAAAVPVLCSAVFVIGLASVTRRRGTAAPNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RL9</accession>
    <name>Q63RL9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative branched-chain amino acid transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522271.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109249.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2653"/>
    <dbReference type="EnsemblBacteria" id="CAH36661">
        <property type="protein sequence ID" value="CAH36661"/>
        <property type="gene ID" value="BPSL2653"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2653"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2692"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VFFNFFN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266540" evidence="7">
        <location>
            <begin position="24"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="42510" checksum="8DDF395C684DA795" modified="2004-10-25" version="1">MTSTIHSLAVARGASPASSTASAASASPAAPRFALGLPPRPALLSRRAWLALVALCIAVGVGVPLAALVAPEASAFHLSSYAMTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMRAIGRDGKYGSDLPDFMVFLDWHRLPWYWSGTEHLAYALALVVLVPAALAWVFGFFTFRSRVKGVYLSIITQATTFAAMLLFYRNETGFGGNNGFTDFKRIAGFAITSPGTRTVLLLTTFAALVASFVAARAIVTSKLGRVVTAIRDGETRVMFLGYSPLAYKLFVWVVSAVLCAIAGALYVPQVGIINPSEMSPGNSIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAEYWLFFLGLIFVLVPLVLPRGIMGLVETVMRKATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RN8</accession>
    <name>Q63RN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194941.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109230.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36642">
        <property type="protein sequence ID" value="CAH36642"/>
        <property type="gene ID" value="BPSL2634"/>
    </dbReference>
    <dbReference type="GeneID" id="56594841"/>
    <dbReference type="KEGG" id="bps:BPSL2634"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2715"/>
    <dbReference type="eggNOG" id="ENOG5033BXT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGYGGWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266734" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="10370" checksum="5FCD3EEB9B482531" modified="2004-10-25" version="1">MKKLIPLIAVAALGLGAASAARAHVSIGVGIGVPIAPAYPVYAAPPPVYYAPPPPPVVYAPAPVYYGPPAVVVGGGYYGRPYWRHYHGYYGRPYWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RN9</accession>
    <name>Q63RN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186291.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109229.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2633"/>
    <dbReference type="EnsemblBacteria" id="CAH36641">
        <property type="protein sequence ID" value="CAH36641"/>
        <property type="gene ID" value="BPSL2633"/>
    </dbReference>
    <dbReference type="GeneID" id="56594843"/>
    <dbReference type="KEGG" id="bps:BPSL2633"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3002"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QTQHLGQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="327" mass="34169" checksum="E77DC28F9244C21F" modified="2004-10-25" version="1">MSVQSASDLILPTFDDVTDAAARLAGVAHRTPVLTSSTADARAGATIFFKCENFQRMGAFKFRGAYNAISHFDAEQRRAGVLTYSSGNHAQAIALAARLAGIRATIVMPHDAPAAKVAATKGYGGEVITYDRYTESREEIGARLAQERGMTLVPPYDHPHVIAGQGTAAKELIDEVGELDMLVAPLGGGGLIAGTALSAAALSAGCAVIGVEPEAGNDAQQSLERGEVVRIPVPRTIADGAASTHVGAYNFPVIQRLVKRIVTASDAQLVDTMRFFAERMKLVVEPTGCLGAAAVLDGVLPVAGRRIGVILSGGNVDLARYGEFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SL7</accession>
    <name>Q63SL7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193928.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108899.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2303"/>
    <dbReference type="EnsemblBacteria" id="CAH36306">
        <property type="protein sequence ID" value="CAH36306"/>
        <property type="gene ID" value="BPSL2303"/>
    </dbReference>
    <dbReference type="GeneID" id="56596098"/>
    <dbReference type="KEGG" id="bps:BPSL2303"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3124"/>
    <dbReference type="eggNOG" id="COG4566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMTADRT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="212" mass="23645" checksum="72A23E6F0F53FCF2" modified="2004-10-25" version="1">MNSPVTTSQETVFVVDDDEAVRDSLRWLLEANGYRVQCFSSAEQFLDAYQPAQQAGQIACLILDVRMSGMSGLELQERLIAENAALPIIFVTGHGDVPMAVSTMKKGAMDFIEKPFDEAELRKLVERMLEKARNESKSVQEQRAASERLSKLTAREQQVLERIIAGRLNKQIADDLGISIKTVEAHRANIMEKLNVNTVADLLRLALSKKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SN0</accession>
    <name>Q63SN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195928.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108886.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2290"/>
    <dbReference type="EnsemblBacteria" id="CAH36293">
        <property type="protein sequence ID" value="CAH36293"/>
        <property type="gene ID" value="BPSL2290"/>
    </dbReference>
    <dbReference type="GeneID" id="56596084"/>
    <dbReference type="KEGG" id="bps:BPSL2290"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3139"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGLTIMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010242">
        <property type="entry name" value="TF_HTH_IscR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02010">
        <property type="entry name" value="IscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="179" mass="19563" checksum="152825962F727FB4" modified="2004-10-25" version="1">MRLTTKGRFAVTAMIDLALRQEQGPVTLAGISQRQRISLSYLEQLFGKLRRHEIVESVRGPGGGYNLARRAQDVTVADIIIAVDEPLDATQCGGKGACEGSKQPDGHCMTHELWSTLNQKMVEYLDSVSLQDLVDQQRAREGTPAVLRDKRKPEPVAASVEPVRSVPLGPNSVFNIANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SQ7</accession>
    <name>Q63SQ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108859.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2263"/>
    <dbReference type="EnsemblBacteria" id="CAH36266">
        <property type="protein sequence ID" value="CAH36266"/>
        <property type="gene ID" value="BPSL2263"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2263"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2571"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="30210" checksum="1905A5D5CAD5BFE7" modified="2004-10-25" version="1">MPTMNADLHCHSNVSDGQLAPADVARRAHAGGVTLWALTDHDEVGGQRAAREAAEALGMRYLHGVEISVTWASRTVHIVGLNIDPRNPALVDGLHRTRNGRAARAVAIGDALAALGIEAAYEGALAYVSNPDLISRTHFARFLVDKGYAASMSDVFDRYLGDGKPGYVAHRWAKLSDAVAWIRQAGGEAVVAHPGRYAYTSVEFDAFFGEFIELGGVAIEVVTGSHTPDQYREYADVARRFGFEASRGSDFHAPGEGRTEFGSLPPLPSDLKPVWERWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SZ8</accession>
    <name>Q63SZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108768.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2173"/>
    <dbReference type="EnsemblBacteria" id="CAH36175">
        <property type="protein sequence ID" value="CAH36175"/>
        <property type="gene ID" value="BPSL2173"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2173"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="75" mass="9121" checksum="2CB7E41C4D9F2824" modified="2004-10-25" version="1">MRGSRASRHGRGRDVRDRHVRDRHVRNRHVRDRHVRDRHVPLMRGGRLRARFGKMRVSGARSRRRVASFWYPTRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T26</accession>
    <name>RNH2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease HII</fullName>
            <shortName evidence="1">RNase HII</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhB</name>
        <name type="ordered locus">BPSL2145</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534532.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108740.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T26"/>
    <dbReference type="SMR" id="Q63T26"/>
    <dbReference type="STRING" id="272560.BPSL2145"/>
    <dbReference type="EnsemblBacteria" id="CAH36147">
        <property type="protein sequence ID" value="CAH36147"/>
        <property type="gene ID" value="BPSL2145"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2145"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3308"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGKHDYL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235706" description="Ribonuclease HII">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <sequence length="214" mass="22657" checksum="2C31F96425CE25B6" modified="2004-10-25" version="1">MATTRKPRGGAGGATQPALDFDAPGEIVCGVDEAGRGPLAGPVVAAAVVLDPARPIVGLDDSKALSAKKRERLFDEIVVHALAYSVASASVEEIDSLNILHATMLAMKRAVEGLSVLPTLAKIDGNRCPMLAIRSEAIVGGDALVPSISAASILAKVTRDRMLVELHQQFPMYGFDAHAGYGTPQHLAALREHGPCEHHRRSFAPVREAFDLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T37</accession>
    <name>Q63T37_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193566.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108729.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2134"/>
    <dbReference type="EnsemblBacteria" id="CAH36136">
        <property type="protein sequence ID" value="CAH36136"/>
        <property type="gene ID" value="BPSL2134"/>
    </dbReference>
    <dbReference type="GeneID" id="56529058"/>
    <dbReference type="KEGG" id="bps:BPSL2134"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3322"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYPLRNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="322" mass="33939" checksum="65053D49666B1217" modified="2004-10-25" version="1">MQRGVVYGVLAGALWGMVFLVPRLLTDFSPLLLSVGRYAMYGLVSLAAALPAARSLASRLTHDDLVALVKLALVGNVAYYMLLSSAVHLIGIAPSSLIVGVLPVTVTLAGLGDHGAVPLKRLAGPLALVVAGIACINVDLFTSEAAHATTLAQKLAGIACATGALASWTWYAVANARYLQRHHHFDGNEWSVLWGVVTGLIGGLCWIGIAALPAGALQPALPASRWQLFWLLNLGLAIGASWLGNGLWNAASKRLPLTLSGQLIVFETVFALLYGFVFDHRLPRVLEIAALVLLLAGVYGSVRRHGDKRAADDPLNANLGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TA0</accession>
    <name>Q63TA0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192729.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108666.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2067"/>
    <dbReference type="EnsemblBacteria" id="CAH36068">
        <property type="protein sequence ID" value="CAH36068"/>
        <property type="gene ID" value="BPSL2067"/>
    </dbReference>
    <dbReference type="GeneID" id="56595332"/>
    <dbReference type="KEGG" id="bps:BPSL2067"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.56"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266567" evidence="2">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="71" mass="7480" checksum="A3D494684A173A79" modified="2004-10-25" version="1">MKLVFPACLAFVAGIVCFARFAASGSHVDAFGRLHEPFGLLPLGWALTLLGGTGLLIGAAQAVVRRSARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TC9</accession>
    <name>Q63TC9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526759.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108637.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2040"/>
    <dbReference type="EnsemblBacteria" id="CAH36039">
        <property type="protein sequence ID" value="CAH36039"/>
        <property type="gene ID" value="BPSL2040"/>
    </dbReference>
    <dbReference type="GeneID" id="56526403"/>
    <dbReference type="KEGG" id="bps:BPSL2040"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.23"/>
    <dbReference type="eggNOG" id="ENOG5032MIM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HFARQME"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="291" mass="34612" checksum="6BA410E039154ABC" modified="2004-10-25" version="1">MVAFDLDSRNFLAFQYAVINPLQVDEEAWADLETVPLVPDRYREQVHLFPRLVSLTPLEANARADLLARAQQWDREYDDPYFSTLLHTTKDIDFIRTHLIAQMEQYHLARREYDVIRLHDPKVLRHLSWLLSADQWESLLGPIEAWAWREPDGTWWYRERDVRVTDVPSRMRLSPEQWTTLLRFGEINQTLMLLSRAAPDLVDDASLAQRLNALLADAWNIHRLTDRSDRILYAIQAIRFHPRIHDHPEMRRRLRQPHDDDSSYADRCDDLDDATMQRVVDEMNHPYKEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TF8</accession>
    <name>Q63TF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipid metabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205107.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108608.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2010"/>
    <dbReference type="EnsemblBacteria" id="CAH36009">
        <property type="protein sequence ID" value="CAH36009"/>
        <property type="gene ID" value="BPSL2010"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2010"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2266"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="406" mass="43665" checksum="D140F492799331CB" modified="2004-10-25" version="1">MGALSHIRVLDLSRVLAGPWCAQTLADLGADVIKVERPECGDDTRHWGPPYLKTPDGADTREAAYYLAANRNKRSVTVDIATPEGQRIIRELAAQCDVVLENYKVGQLAKYGLDYASLAAVKPGLVYCSVTGFGQTGPYAHRAGYDFIIQGMGGFMSITGERDGLPGGGPQKAGVAIADLATGLYSTIAILAALAHRDRTGEGQHIDMALLDVQVALLANMNTNFLASGKPPVRWGNAHPNIVPYQTFETSDGWIIVAVGNDGQFRKFVEAGGRPELADDERFATNPARVRHRDTLVPIVAAMTKTRTKREWLDALDPLGVPCGPINDLAEVFDDEQVRARGMQVDLPHPSGASAKLVRNPIRMSATPPDARSAPPLLGEHTDAVLRDMLGYGDAAIAALRDKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TI9</accession>
    <name>Q63TI9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555925.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108577.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1979"/>
    <dbReference type="EnsemblBacteria" id="CAH35978">
        <property type="protein sequence ID" value="CAH35978"/>
        <property type="gene ID" value="BPSL1979"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1979"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4131"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="284"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="787" mass="86659" checksum="C3CCD7726AE3ABF9" modified="2004-10-25" version="1">MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIRQGYAAPATVLAVTFTNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPEKVDATDSFNRKFVELYQAYEQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAIFAVGDDDQSIYAFRGANVGNMRDFEHEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHRLGKNLRTDAGHGEPVRVYEAATDAQEAAWIVEEIRSLVNAGLARSEVAVLYRSNAQSRSIEHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSIEQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETARMSLPETVEHVVRASGLADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGADPADAVLAPANLADPAQNPDAMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRYNIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWSRDWFARPGGGARQGVVDAAVSAPLPALANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAVAKLQAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TN6</accession>
    <name>Q63TN6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193694.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108530.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1931"/>
    <dbReference type="EnsemblBacteria" id="CAH35930">
        <property type="protein sequence ID" value="CAH35930"/>
        <property type="gene ID" value="BPSL1931"/>
    </dbReference>
    <dbReference type="GeneID" id="56595471"/>
    <dbReference type="KEGG" id="bps:BPSL1931"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4074"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEQTAHF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10553" checksum="12E36DAF4A070191" modified="2004-10-25" version="1">MSEVAVVALIVAKPGAEAKLLEQLEGIVGPTRSEEGALQYDLHRDLQEPRRFIFIERWASEAALAAHARSAHIDAYKRAAADWIESSEIRVASKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TP0</accession>
    <name>Q63TP0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199444.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108526.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1926"/>
    <dbReference type="EnsemblBacteria" id="CAH35926">
        <property type="protein sequence ID" value="CAH35926"/>
        <property type="gene ID" value="BPSL1926"/>
    </dbReference>
    <dbReference type="GeneID" id="56595467"/>
    <dbReference type="KEGG" id="bps:BPSL1926"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4070"/>
    <dbReference type="eggNOG" id="ENOG5030PFG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTAQRMN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="12048" checksum="D80B2B516A3F64FA" modified="2004-10-25" version="1">MATYSNEAVLDALRRVQYRQVPWARRPGVFEYLRALGLMDTVRQKTVAPAPGFHAPVDIAVLTDNGRVEFTRLERDEKQPDWETRRIEDYALSEASAVSILESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU5</accession>
    <name>Q63TU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266752.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108471.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35871">
        <property type="protein sequence ID" value="CAH35871"/>
        <property type="gene ID" value="BPSL1872"/>
    </dbReference>
    <dbReference type="GeneID" id="56595665"/>
    <dbReference type="KEGG" id="bps:BPSL1872"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4007"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IIHHTAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266778" evidence="2">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="32684" checksum="8AF37DA5624F8890" modified="2004-10-25" version="1">MKFPLRHTLLASFSMLAAACTTPTLVNRGDYYADTSLPARSVDSRIRFLVMHYTEIGEAPSLRVLTQENVSAHYVVPDAPRTERGAPVVYQLVPESERAWHAGVSAWQGATELNGVSIGIENVNRGPIDTPHGRMWAPYPPAQVDAIVRLAKDIVARYRIPPTRVVGHSDIAPQRKIDPGPLFPWRALAKAGVGAWPDDETVAARLAGRPPKSLVDVRELQLKLARYGYDVATDGVLDDRTRRVFSAFQMHFRPTDYAGNPDAETDAIAQALLDKYMPSQPAPERDAAALDAASGVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TZ1</accession>
    <name>Q63TZ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108425.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1826"/>
    <dbReference type="EnsemblBacteria" id="CAH35825">
        <property type="protein sequence ID" value="CAH35825"/>
        <property type="gene ID" value="BPSL1826"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1826"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2057"/>
    <dbReference type="eggNOG" id="COG2719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NSNPCYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="508" mass="60218" checksum="0A788F1C7CA7798D" modified="2004-10-25" version="1">MNVADRKPLPCPSDWTFELIEEYDTHISQVAEQYELDIYPIQLELISAEQMMDAYASVGMPVNYRHWSFGKHFLSTEKSYRRGQMGLAYEIVINSNPCIAYLMEENTMTMQALVIAHAAYGHNSFFKGNYLFRLWTDAHAIIDYLVYAKNYVAECEERYGLDRVEELLDSCHALMNYGVDRYKRPQKPSLAKESELRREREAYLQSQVNELWRTLPAKKPEFADEEQEERYPPEPQENLLYFAEKNAPFLEPWEREVIRIVRKIGQYFYPQRQTQVMNEGWATFWHYTLLNTMYNQGKLADGFMMEFLHSHSNVIYQPPVTKPYYSGINPYALGFSMMSDIRRICEAPTEEDHKWFPELAGSPWLPALHYAMRNFKDESFIAQYLSPHLIREMRLFSVLDDDMRDALEVSAIHDDSGYQYVRQALSRQYDIHHREPNIQVWSVNTRGDRSLTLRHFMTDNRHLSNDSEEVLKHMARLWQFDVYLESVDETGTVRKRYECRYTAPEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U10</accession>
    <name>Q63U10_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192753.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108406.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1807"/>
    <dbReference type="EnsemblBacteria" id="CAH35806">
        <property type="protein sequence ID" value="CAH35806"/>
        <property type="gene ID" value="BPSL1807"/>
    </dbReference>
    <dbReference type="GeneID" id="56595594"/>
    <dbReference type="KEGG" id="bps:BPSL1807"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3927"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGRGQWQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="26"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="247" mass="25779" checksum="8B14EBC93F0814C7" modified="2004-10-25" version="1">MDLSILANNLPYLLVGAFPDGSLGGAALSLVLALASALASAGLGVALGVALALATGALRGALVVVIGFFRAIPVLMLIFWTYFLLPVLLHADVPGLAAVVCALSLVGGAYLAHSVHAGIRAAGDGQWQAGLALGLTRWQTVRHVLLPQAVRIMTPSFVNQWVSLVKDTSLAYIVGVPELSFVATQVNNRLMVYPAQIFLFVGVIYLILCTALDVAATRLLAHRRRRAPRGDDATRASAAQPAAGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U44</accession>
    <name>Q63U44_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="5 8">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobO</name>
        <name evidence="10" type="ordered locus">BPSL1772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="5 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192682.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108372.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1772"/>
    <dbReference type="EnsemblBacteria" id="CAH35771">
        <property type="protein sequence ID" value="CAH35771"/>
        <property type="gene ID" value="BPSL1772"/>
    </dbReference>
    <dbReference type="GeneID" id="56595559"/>
    <dbReference type="KEGG" id="bps:BPSL1772"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3878"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="200" mass="22179" checksum="474A8584BA90E0AC" modified="2004-10-25" version="1">MKTDSESHQRMAERRRAGHEKKQAAATVEKGLLIVHTGNGKGKSTAAFGMAVRMLGHGMRTGVVQFIKGALHTSERDFLGANAQCDFVTMGDGYTWNTQNRDADIATARRGWDEARRMIESGDYRMVILDELNTVLKYEYLPLDEVLATLAARDPALHVVVTGRHAPDALVDAADLVTEMRLVKHPYKEQGVKAQRGVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UM8</accession>
    <name>Q63UM8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544422.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108188.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1568"/>
    <dbReference type="EnsemblBacteria" id="CAH35569">
        <property type="protein sequence ID" value="CAH35569"/>
        <property type="gene ID" value="BPSL1568"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1568"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3618"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PQSRTFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="59"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="39299" checksum="D0BD28DA6E6F5E57" modified="2004-10-25" version="1">MNRSGSRAALLIGVALIAAACHRKEAAPSAPRPVVAVPAQADGAAAAVSLPGEIQPRYATPLSFRIAGKLVERKVRLGDIVKKGQVVALLDTSDVARNAASAQAQLDAATHALTFAQQQRERDRAQARENLIAPAQLEQTENAYASARAQRDQAAQQLALAKNQLQYATLVADHAGYITAEQADTGQNVSAGQPVYQLAWSGDIDVVTDAPESELPRLAPGRTARVTLPALPGRAFDARVREIAPAADPQSRTYRVKLTLAQPDAAVRLGMTANVALSPDAPSAANAQPRFTLPSTALFHAGNAPALWIVRKQDDTLELRRVDVVRYNERTVTVSGGIQPGERVVLQGVHTVSAGEKVRAVPPLHPEDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UP0</accession>
    <name>Q63UP0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="9">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">potG</name>
        <name evidence="9" type="synonym">potA</name>
        <name evidence="11" type="ordered locus">BPSL1556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108176.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1556"/>
    <dbReference type="EnsemblBacteria" id="CAH35557">
        <property type="protein sequence ID" value="CAH35557"/>
        <property type="gene ID" value="BPSL1556"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1556"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1749"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLHSGQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="378" mass="41378" checksum="666A799AE21259F0" modified="2004-10-25" version="1">MAGAPSYRPQTGADGRAENFVQIIDVVKKFGETVAVRNVELSVRKGELFALLGSSGCGKSTLLRMLAGLETITSGKILIDGEDLAQMPPYKRPVNMMFQSYALFPHMTVEANVAFGLKQEGVPKAELKERVRDALELVQMARYASRKPHQLSGGQQQRVALARSLVKRPKLLLLDEPMSALDKQIRQRTQIELVNILDKVGVTCIMVTHDQEEAMTMAGRLAVMSEGQIVQIGTPHEVYEYPNCRFSAEFIGSTNLFEGVTVEDEPDHVFIESPDLPCRLYVNHGITGPLGMPVTVSVRPERIALTRKPADGAYNWGRGVVTNVAYMGGYSLYHVKLDSGKTVIANVSSLAIADLDSPGWGDEIYVRWSAAAGVVLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UV7</accession>
    <name>Q63UV7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550337.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108109.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1489"/>
    <dbReference type="EnsemblBacteria" id="CAH35490">
        <property type="protein sequence ID" value="CAH35490"/>
        <property type="gene ID" value="BPSL1489"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1489"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3523"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGNQKVG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="451" mass="47424" checksum="227E92A13D69AF6A" modified="2004-10-25" version="1">MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGMSIYVSIYIGLTGILSALQPIAGQLYGARRYAEIGEEVRQAMWLAVLLAAPGFLLLHFPHPLLRLAHAPAELTDRTVAYLRILSFGLPASLLFRIYNALTNAAGKLRLAMILQVGTLAVKVPLNLWFIFGGLGVPALGGPGCGLASTLINWALAIVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLVLGVPMGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVASSTLVARALGAGRFDEARALGRHGVALACGLACAYGIVVFALRPLIVSGYTPNPAVAAAAMPLVAIVTVYHFFDALQITTAFVLRAHKMAVVPTAIYAIALWGVGLGGGYLLGFDVGGAVPAQFTGARGFWIASAASLMLAGGGLALYLRHIGKRETGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V18</accession>
    <name>Q63V18_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550299.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108048.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1426"/>
    <dbReference type="EnsemblBacteria" id="CAH35428">
        <property type="protein sequence ID" value="CAH35428"/>
        <property type="gene ID" value="BPSL1426"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1426"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3446"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SMRPDDL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="392" mass="40860" checksum="3EDEA8EEFF753625" modified="2004-10-25" version="1">MTEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVERAKLDPARVEDVLIGCANPEGATGANIARQIALRAGLPVGVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCVQNEMNRHMLREGWLDAHKPEIYWTMLQTAENVAKRYGISKARQDEYGVNSQLRATAAQAAGRFNAEIVPITVRAGVADKATGRLYTKEVTLAADEGIRPDTTLEGVAKIRAALPGGVITAGNASQFSDGAAACVVMNAKVAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLLKQAGLKVSDIDLWELNEAFAVQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VB6</accession>
    <name>Q63VB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107950.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1325"/>
    <dbReference type="EnsemblBacteria" id="CAH35323">
        <property type="protein sequence ID" value="CAH35323"/>
        <property type="gene ID" value="BPSL1325"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1325"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1486"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDNCLTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044248">
        <property type="term" value="P:cellular catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="310" mass="33483" checksum="CA9A25EA09F6F7C2" modified="2004-10-25" version="1">METPPMKIQRIAVVGAGVIGASWTAFYLSKGFDVAVTDPAPGARERLDAALANFLGERAGTLASRVAFEPTLDAALEGADFVQENGPERLDFKRELYRRIDARLPAHVLVASSSSGLKMSDIQTACDAHPQRCLVAHPFNPPHLIPLVELVGGAATSADAIARAKRFYDSLGKVTIVLNKERAGHVANRLAAALFREVYYLVGEGVVSVEDADKAVSWGPGLRWGLMGQSLVYHLGGGEGGIAHFLEHLSGPMASWWNDLGAPSFSPDVDRQLIDALREIQGAHSMRELGAERDRLLVELIDARRNSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL7</accession>
    <name>Q63VL7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185972.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107849.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1227"/>
    <dbReference type="EnsemblBacteria" id="CAH35222">
        <property type="protein sequence ID" value="CAH35222"/>
        <property type="gene ID" value="BPSL1227"/>
    </dbReference>
    <dbReference type="GeneID" id="56595161"/>
    <dbReference type="KEGG" id="bps:BPSL1227"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.299"/>
    <dbReference type="eggNOG" id="COG5319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARRMHYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009562">
        <property type="entry name" value="DUF1178"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06676">
        <property type="entry name" value="DUF1178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032131">
        <property type="entry name" value="UCP032131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="140" mass="15355" checksum="01B545A0259C3789" modified="2004-10-25" version="1">MKVLDLQCPHGHRFEGWFASADEFEAQLSRKLVECPVCGATEVSRMPSAPRLNLSGATQAQPADPRALQAQAMRALREVLAKTENVGERFAEEARRIHYNEAPARSIRGVTTPEDARALAEEGIDVMPLPVPAALKEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ9</accession>
    <name>Q63VQ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1185"/>
    <dbReference type="EnsemblBacteria" id="CAH35180">
        <property type="protein sequence ID" value="CAH35180"/>
        <property type="gene ID" value="BPSL1185"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1185"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.343"/>
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="193"/>
        </location>
    </feature>
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            <end position="225"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="635" mass="68377" checksum="19F8C70C46E1B1F3" modified="2004-10-25" version="1">MQGNASPGGRRTTASAQRAGSSDNHSRSPSVALAAGAPGTVGAAGERAIGSRGAAATRTALTGWRAWFVAAAVLCAYLLPGILGHDPWKQDETYTFGIIQHMLESGDFVVPTNAGQPFLEKPPLYDWVATGFAWLFSRFLPLHDAARLASALFAALAFGFTARAARVATGAARWLELPVIGTVALCAGSLVVIKHSHDLMTDVALMAGAAMGFCGLLELVIRHAGDAFGARAERPPANRFAAPLFGLGVGIALMSKGLFVPLVFGATLAATLVLYPACRSRAFFRSLAIAALVCAPFALIWPTALFLRSESLFLVWFWENNVGRFFGFSVPTLGAENDKPLFIWRALLTVGFPVAPLALVALARGLWRDWRAPRVALPLTFAGIGMVVLHISATSRQLYILPFIAPLALVAAQAIPRLPQRLHAAWDYASRLLFGAAAALVWIVWSLMSDHGGPRAGLQWLGRWLPLDWTMPIEPALVLSALAITIGWVGLLPSLRLAGKWRGALSWAMGALVAWGLVYTLLLPWLDVAKSYRSVFEDLNRRLALEWNDGDCMASVDLGESEAPMLYYFSGVLHQPVAQPNASACTWLIVQGTRANPPVLDAEWKPFWAGARPGDEQEMLRVYVRTPAAARPAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VT6</accession>
    <name>Q63VT6_BURPS</name>
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        <submittedName>
            <fullName evidence="7">Ribonuclease G</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cafA</name>
        <name evidence="7" type="ordered locus">BPSL1158</name>
    </gene>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1158"/>
    <dbReference type="EnsemblBacteria" id="CAH35153">
        <property type="protein sequence ID" value="CAH35153"/>
        <property type="gene ID" value="BPSL1158"/>
    </dbReference>
    <dbReference type="GeneID" id="56526704"/>
    <dbReference type="KEGG" id="bps:BPSL1158"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
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        <property type="entry name" value="S1_dom"/>
    </dbReference>
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        <property type="entry name" value="S1_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="488" mass="54790" checksum="EFBB7CE3180A5E96" modified="2004-10-25" version="1">MNEEILINITPQETRVALVQQGAVQELHVERTLSRGRVGNVYLGKVVRVLPGMQSAFIDIGLERAAFLHVADIWQPRAGDAPAAATHQPIEKIVFEGQTLMVQVIKDPIGTKGARLSTQISIAGRTLVYLPQEPHIGISQKIESEAEREAVRARLTAVIPSDEKGGYIVRTIAEDATSDELAADVAYLRKTWATIVAQGQRVPPTSLLYQDLDLAQRVLRDFANDDTTRIQVDSRETHQRLVEFAAEFTPAVSPKLHHYTGERPLFDLYNIEAEIQRALSRRVDLKSGGYLMIDQTEAMTTIDVNTGGYVGARNFDDTIFKTNLEAAHTIARQLRLRNLGGIIIIDFIDMENAEHRDAVLAELKKALSRDRTRVTVNTFSQLGLVEMTRKRTRESLAHVLCEPCPTCQGKGQVKTSRTVCYDILREILRESRQFNPREFRVIASQQVIDLFLDEESQHLAMLIDFIGKPVSLQVESNLSQEQYDIVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W68</accession>
    <name>Q63W68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAH35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107648.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1020"/>
    <dbReference type="EnsemblBacteria" id="CAH35016">
        <property type="protein sequence ID" value="CAH35016"/>
        <property type="gene ID" value="BPSL1020"/>
    </dbReference>
    <dbReference type="GeneID" id="56526815"/>
    <dbReference type="KEGG" id="bps:BPSL1020"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.548"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VWVNRYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="12"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="479" mass="50225" checksum="12746B7D3B1A9C4E" modified="2004-10-25" version="1">MEEAKHFIAGAWAPPAGGETIAVIDPSDGEPFARLARGTAPDVGAAVQAARAAFDGSWGALGAADRGRMLYRLSMLVAACREELALIESRDTGKPLTQARADADALARYLEFYAGAADKLHGETLPYRDGYTVLTLREPHGVTGHIVPWNYPMQILGRSVGAALAAGNACVVKPSEDACLSILRVATLAAEAGLPEGAFNVVTGYGHEAGAALARHPGVDHLSFTGSPDTGRLVAQMAAEHHASVTLELGGKSPQIVFADADLDAALPVLVSAIVQNAGQTCSAGSRVLIDKAVYEPLVERLATAFNGLKVGPGRADLDCGPLINAKQQQRVWDFLSDAQHDGITMAAHGQVVPDAPETGFYQAPALLRDVPHTHRLAQEEVFGPVLAAMPFADEDEALALANGTPFGLVAGIWTRDGARQMRLARKVRAGQVFVNNYGAGGGVELPFGGTGRSGYGREKGFEALYGFTVLKTIALRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WF9</accession>
    <name>Q63WF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107557.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0929"/>
    <dbReference type="EnsemblBacteria" id="CAH34924">
        <property type="protein sequence ID" value="CAH34924"/>
        <property type="gene ID" value="BPSL0929"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0929"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1012"/>
    <dbReference type="eggNOG" id="ENOG50329M1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FELSYVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="90" mass="9614" checksum="61076B44F93E6254" modified="2004-10-25" version="1">MLPRSMAASSSPAILEPNHNTFQVWGDMMTIDNPIEISSVMLAFAALGAIIIGGLLTAMHLKRKYHPNLIGALIGALLCFLLIEALPAIT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WL3</accession>
    <name>LPXK_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="1">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxK</name>
        <name type="ordered locus">BPSL0878</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl}-(1-&gt;6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucosaminyl}-(1-&gt;6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate}.</text>
            <dbReference type="EC" id="2.7.1.130"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107503.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WL3"/>
    <dbReference type="SMR" id="Q63WL3"/>
    <dbReference type="STRING" id="272560.BPSL0878"/>
    <dbReference type="EnsemblBacteria" id="CAH34870">
        <property type="protein sequence ID" value="CAH34870"/>
        <property type="gene ID" value="BPSL0878"/>
    </dbReference>
    <dbReference type="GeneID" id="56594747"/>
    <dbReference type="KEGG" id="bps:BPSL0878"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.718"/>
    <dbReference type="eggNOG" id="COG1663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDDGFQN"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229947" description="Tetraacyldisaccharide 4'-kinase">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <sequence length="342" mass="36511" checksum="CD2A8570EF47C3D2" modified="2004-10-25" version="1">MSARPGLLARAEARLTREWQRRGALAWALAPFACAFGAIAALRRAAYARGWKARVDCGVPVVVVGNVTVGGTGKTPTVIALVDALRAAGFTPGVVSRGYGAKIAAPTAVTAASPPQQAGDEPLLIARRTLAPVWVCPDRVAAVRALKAAHPEVDVVVSDDGLQHYRLARAVEIVVFDHRLGGNGFLLPAGPLREPLSRRRDATLVNDPYSRALPPWPDTFALSLAPGDAWHLDRPSRRKPLAQFAGERVLAAAGIGAPERFFATLRAAGVAPATRALPDHYAFATNPFVDDHFDAILITEKDAVKLGTSWRDARIWVVPVEAALDPRLIALVVEKLRGRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WT2</accession>
    <name>Q63WT2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526225.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107434.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0809"/>
    <dbReference type="EnsemblBacteria" id="CAH34801">
        <property type="protein sequence ID" value="CAH34801"/>
        <property type="gene ID" value="BPSL0809"/>
    </dbReference>
    <dbReference type="GeneID" id="56527011"/>
    <dbReference type="KEGG" id="bps:BPSL0809"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.794"/>
    <dbReference type="eggNOG" id="ENOG503310H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NAPIDMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266402" evidence="1">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="140" mass="14776" checksum="1972E2FA00DD57F1" modified="2004-10-25" version="1">MRQQSVSQYLIAAALAFGLAGVARAQPGLPDVQHHGDVGFVSGGVGLDESTAFQRSESSWPLALRFTGAGGEYLSDVHVSVLDARGGEVLKTDARGPYMLVRLKPGRYTVRASYNGSEQTHAVTVPAKGGTKAAFSWKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WT4</accession>
    <name>Q63WT4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526222.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107432.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0807"/>
    <dbReference type="EnsemblBacteria" id="CAH34799">
        <property type="protein sequence ID" value="CAH34799"/>
        <property type="gene ID" value="BPSL0807"/>
    </dbReference>
    <dbReference type="GeneID" id="56527014"/>
    <dbReference type="KEGG" id="bps:BPSL0807"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.797"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPWLRPT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="220"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="47058" checksum="0545053DDE8F7AF5" modified="2004-10-25" version="1">MRSIRHQLLIWLLAIVVAGVGLAGWMIYRQALAAANELFDYQLQQIAAALPSEPFSQVLGSQTNGDEGIVIQIWNRNGVLMYFSHPRAPIAPRAELGFSTERTERGAWRVYGAIVGDNVVQLAQPLSVRNRLAASVALRTLWPLIVLLPFLGAAVWMIVGRGLAPLQRVTRAVEARRPEALDPLPDSPLPLEVRPLVRALNGLLARLSAALDTQKAFVADAAHELRTPLAAVQIQAQLVARAQDDVSRREAIVDLQSGVTRATRLAEQLLALARAEPGDATVRERVDLRAIVEECVAAHAPLAQRRDIDLGFERVEDASVDADPAALRVMFNNLLDNAVKYTPAGGRIDVSLTRGEGARACVQIGDSGPGIPAAERERVFDRFYRDTSARARTDVAGSGLGLAIVKRVAAQQRASVTLGEAAAGGLLVSVSLPCVGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WX1</accession>
    <name>Q63WX1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107395.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0770"/>
    <dbReference type="EnsemblBacteria" id="CAH34762">
        <property type="protein sequence ID" value="CAH34762"/>
        <property type="gene ID" value="BPSL0770"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0770"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.826"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANWLYSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022205">
        <property type="entry name" value="DUF3732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12532">
        <property type="entry name" value="DUF3732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="648" mass="72891" checksum="225D94C9DE5E2DA7" modified="2004-10-25" version="1">MMQVIAISVYSCDGRRRAVPFRRGLNVVSGDSKTGKSTLIEILDYCFGADECSVPDGVVRSKVAWYGVLLHLGDAGRAFIARRAPSPPAKSTEDIFLQMGAEELKLPSAKQLRKTTNLEGLIAQLTSWVGIKETLHVPPPGQTRRALSTNIRHALAFCLQTQNEIDQKGYLFHGAADNFVSQALKDSLPYLLGAAGEDQMAKRFELKVCRDKLRSIDRTLRELEDIRGKGNERASSLLTEARLVGLTDLVQPESWQAAVAELKRIAESPIGRNPPPQADEDEFARLSSERARLQDQIRSKRHAIDTARAFENHGLEFEQEVQEQARRLGLVELFSSERTAHACPLCSQSLQEQEIDSVANLQLFHNDLLEHSTAVRTSTPHIQAAIEAYESDVSALLERLSVVRMQLNAIRANDQRLQKYHDDAARSALVVGRISLYLESLPEETDTSGMHLERDRLAGICKELEAALSHQLMAERLESILGRINPAISEHAETLKLEFSDSPVRFDVRNLTVVADTLDGPVPLKRMGSGENWVGYHLVVHLALHEWFAQKNRPVPNFLIIDQPSQAHFPADSGNGTKKKDIDRDTVRRMYELMAQSSSVQGREYQVIVTDHADFDDPEFQKHVRHRWRDGEKLIPEDWPRCYGEERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X18</accession>
    <name>Q63X18_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL0722</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
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            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="protein sequence ID" value="CAH34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0722"/>
    <dbReference type="EnsemblBacteria" id="CAH34714">
        <property type="protein sequence ID" value="CAH34714"/>
        <property type="gene ID" value="BPSL0722"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0722"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.889"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYPLWDQ"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
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        <property type="entry name" value="Cyt_C_Oxase_1"/>
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        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
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        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="81"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="208"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="249"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="327"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="472"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="644"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="762"/>
            <end position="786"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="941" mass="101719" checksum="A2A4EE9A21E04527" modified="2004-10-25" version="1">MSTADTDRRARLAYRRAPEIGEAGPGSAAERRLAALWESRPGWRGWLATVDHKRIGLRYIVTAFAFLLAGGAEALVMRIQLAQPNGTLLNPEQYNQLFTMHGVTMIFLYALPVLSGFANYLWPLMLGSRDMAFPRLNAFSYWVFVAAGAFLYASFPLGEAPNGGWFNYVPLTTLDYSRGPNIDVYALGMILLGVSTTVGAANFVVTLLRMRAPGMSIDRLPIIVWGTLTASFANLFAVPAVSLAFLLLWLDRNVGTHFFDVAAGGRPLLWQHLFWMFAHPWVYVVVLPAMGIVSDAMPTFCRRPLVAYAAVAVSTVATMLIGFEVWVHHMFATGIAPLALAFFGAASMLISVPSAVAVFAWLATIWTGRPVFKTPFLYFAGFVLMFVIGGVSGVMTAAVPLDWQLTETYFIVAHLHYVLLGINVFPVLGGIAYWFPKFTGRMMNERFGKLTFFVILIGFNVGFFPMHLSGLFGMPRRIYTYPPGMGWDTTNLVTSLGSFVLGAGVLMFVGHALWSMKRGARASADPWGAAGLEWSVSSPAPAYNFAALPIVASRHPLWEAQLAPHARRSSLRRGYLLADGREALGVTPLSGRPDVILKMPDDTSSPLALALFATLACAGLALRSPGIVAAGALGCAAAMLAWLWPRRSLGQREPPLAAAAPARAPNGTDVAHTAHADGGEHTGRAAVANATNATNATNATNATNATNATNATNATNATNATNATNATNATNATNATNAAGATCAAYARELPVGSAGEHAGGWWGMATLIATEAALFGYLIFSYFYLQSQTPERWPPEGLPKLALASFNTAVLVSSSVFVWLADRLVARRRPRAASVALAVAIALGAAFALIQWHEWRGHPYGMTAHLYGSLYFTITGFHLAHVVVGLAVLAALAFWTMRGYFDDRRRAALSIGGLYWHFVDIVWLFIFTTLYLTPIWLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X88</accession>
    <name>Q63X88_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
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    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
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        <property type="protein sequence ID" value="CAH34642.1"/>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0649"/>
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        <property type="protein sequence ID" value="CAH34642"/>
        <property type="gene ID" value="BPSL0649"/>
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    <dbReference type="GeneID" id="56596656"/>
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    <dbReference type="PATRIC" id="fig|272560.51.peg.973"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
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    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="194"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="811" mass="87633" checksum="CA5B4494DCC51931" modified="2004-10-25" version="1">MSNFNIRKVAVLGAGVMGAQIAAHLVNARVPVLLFDLPAKEGPKNGIALKAIENLKKLSPAPFGVKDDAKYLEAANYEDDIAKLAECDLVIEAIAERMDWKHDLYKKVAPHIASHAIFATNTSGLSITTLSDGFADELKARFCGVHFFNPPRYMHLVELIPTAHTRPQILDQLETFLTSVVGKGVVRAKDTPNFIANRVGIFSILAVITEAEKFGLRFDEVDDLTGSRLGRAKSATFRTADVVGLDTMAHVIKTMQDNLADDPFFPVYKTPAVLAKLVEQGALGQKTGGGFYKKEGKAIKVLDAKTGAYVDSGAKADETVGRILKRPPAERLKLLRETQHPHAQFLWSIFRDVFHYIAFHLESIADNARDVDLAIRWGFGWNEGPFEGWQAAGWKQVAEWVQEDIAAGRALANVPLPAWVLDGVVAEKGGVHTAEGSWAPAAQRFAPRPDLAVYDKQVFRAPVFGEAGRDPKTFGKTLFETDSVRAWVDDRAGEDDVVIVSFKSKMNTIGPGVIDGLAQAIELAEKDYKAVVIWQPSSLKLGNPGGPFSAGANLEEAMPAFMMGGAKGIEPFVKKFQQGMLRVKYANVPVVAAVSGLALGGGCELMLHSAKRVVHVESYIGLVEVGVGLVPAGGGLKEAALRAADAATAAGMTSELLKFLTKPFENAAMAKVSMSAHEARAMGYVKPSDTIVFNVFELLDVAKKEARGLAAAGYRAPLKAKEIPVAGRSAIATIKAQLVNMRDGRFISDHDFLIASRIAEAVCGGDVEAGSTVDEEWLLALERRAFVELLGTQKTQERIMGMLQTGKPVRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XL9</accession>
    <name>RL25_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplY</name>
        <name evidence="1" type="synonym">ctc</name>
        <name type="ordered locus">BPSL0520</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XL9"/>
    <dbReference type="SMR" id="Q63XL9"/>
    <dbReference type="STRING" id="272560.BPSL0520"/>
    <dbReference type="EnsemblBacteria" id="CAH34510">
        <property type="protein sequence ID" value="CAH34510"/>
        <property type="gene ID" value="BPSL0520"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0520"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000181528" description="50S ribosomal protein L25">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <sequence length="208" mass="22466" checksum="4EDC787684210877" modified="2004-10-25" version="1">MEKHMKVVAFERQQQGTGASRRLRNAGKTTGIVYGGEAAPQMIELDHNALWHALKKEAFHSSILDLEVAGKSQRVLLRDVQYHPFRQLVLHVDFQRIDPKKKLHTKAPLHFLNAETSPAVKLSSAVVSHVVTEIEIECLPADLPEFLEVDLSKIEAGQSLHAKDIALPNGVALTAHVDAENPVIASATIPAGAVSDEAAAGEGETPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y39</accession>
    <name>Q63Y39_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525959.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106976.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34338">
        <property type="protein sequence ID" value="CAH34338"/>
        <property type="gene ID" value="BPSL0349"/>
    </dbReference>
    <dbReference type="GeneID" id="56527407"/>
    <dbReference type="KEGG" id="bps:BPSL0349"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1328"/>
    <dbReference type="eggNOG" id="ENOG5032ZTR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TINVMTT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038712">
        <property type="entry name" value="PixA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021087">
        <property type="entry name" value="Uncharacterised_PixA/AidA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12306">
        <property type="entry name" value="PixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20267" checksum="E39C226E94507321" modified="2004-10-25" version="1">MAELVLASSSQEIRVLVVIDTAYIRSLNITPSKDPLQPTGIGHDHQYLLCTGSRGIISGQGTGDLEFRANVGDYVAFTGTSIQDNSDDAVIVYDIKHYSGDKVFNPFSANIITRKGAVEPNPDTPSRNGLPPRHTPINFATFDSKVARSGREGFGIAFGLYTLQSNGQDQDLYGYYWWDPYITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y50</accession>
    <name>Q63Y50_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plcN2</name>
        <name evidence="4" type="ordered locus">BPSL0338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522990.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106965.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0338"/>
    <dbReference type="EnsemblBacteria" id="CAH34327">
        <property type="protein sequence ID" value="CAH34327"/>
        <property type="gene ID" value="BPSL0338"/>
    </dbReference>
    <dbReference type="GeneID" id="56527418"/>
    <dbReference type="KEGG" id="bps:BPSL0338"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1342"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGFRREF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF756" evidence="3">
        <location>
            <begin position="505"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="3">
        <location>
            <begin position="605"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="705" mass="77021" checksum="427C8E706D57B736" modified="2004-10-25" version="1">MTSESRRRFLHTVAQSAGAAAALTVFPESIRRALAIPAASRTGTLRDVEHIVVFMQENRSFDHYFGHLRGVRGYNDRFPIPLPNGKPVWYQPSKANPGKPVLPFRLNTLTTSAQCIGDLDHSWYKTHAAIDGGRYDQWPANKTDMTMGYHVREDIPFHYALADAFTVCDNYFCSLPGPTHPNRSYLMTGTVDPTGRYGGPLLDNSDYVDGDVPPKYDLLTWTTYPERLEANGISWQIYQQGTTGADPLNGNYGTNILQNFANFINAKPGSSLYRRAQTARTLDDLKADVLANKLPQVSWLLPPAAFSEHPRYTPAYGANYTSQILDALTSNPDVWRKTVLFIMYDENDGFFDHVVPPQPATTRAQGLSTVTVDGEIHDVVNPGRGGSYTADGLPYGLGPRVPMTVVSPWTKGGFVCSQVFDHTSVIRFIAARFGIDEPNITPWRRAVCGDLTSAFDFRTPDATLPPLPDTSGYRSIADQLCSTKPAPAVPAAPSPVDPQEPGVRPARALPYELHVNAEVHGGARLRIEFANRGEQGAHFYVYASNRSDGPWRYTVGAHRSLHETFDLAATNGAYAFAVYGPNGFVRVFEGLAAAGGHGRQAAARPEVKAGYDVANGNLYLKLANHGAQSVQLTLADNAYGAPARRITLRGGDEQIESWALASSHQWYDVTVSDGATGQFVRRFAGHVENGKPSYSDPAAIAPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y72</accession>
    <name>Q63Y72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106943.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0316"/>
    <dbReference type="EnsemblBacteria" id="CAH34305">
        <property type="protein sequence ID" value="CAH34305"/>
        <property type="gene ID" value="BPSL0316"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0316"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.349"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGGQHLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="293" mass="28849" checksum="DC7045878736A8C9" modified="2004-10-25" version="1">MLITGAVQTGAAPARAAEAARAGARQAIGAGRPGDAQPGASAPAGAPAHPPRAGEQQAQAPSAPPAARPAPDAAAVGRALAVGFARRGWNVALAAAAGDEARAAAALAAEVEALGRRAAVLAADLAIEADVARLVADCGAALGRPACVIAQAAPVADTARDVGYASLAGAMARSVAAPLVLARTLADATPDAARDDERERAVVIHLLDETLFHPAPERLSHSLAQAALHRATAAQALALAPKVRVVGLVGGRAPRADDIADAACYLADAPGVTGATLTVDGGEHLAPPADERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y94</accession>
    <name>Q63Y94_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106921.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0294"/>
    <dbReference type="EnsemblBacteria" id="CAH34283">
        <property type="protein sequence ID" value="CAH34283"/>
        <property type="gene ID" value="BPSL0294"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0294"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.316"/>
    <dbReference type="eggNOG" id="COG3659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTEFFVS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038673">
        <property type="entry name" value="OprB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0626">Porin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007232292" description="Porin" evidence="2">
        <location>
            <begin position="39"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="509" mass="53741" checksum="E213CC7E775226BB" modified="2004-10-25" version="1">MQRFVMKKKTLHQMLVKSGVASGLPLLLSLGIVQPALAQASSPAAAPAENAAPPAPATRAPDGVPGGNGATAAQTDAAPTGFWDRSNLFGDMGGLRTKLGDHGITLNLQETSEYLRNLSGGTSRGGAYDGLTQFGFSVDTEKAIGLPGGTFNVSGLQIHGTSLTARNLQLLQTASGIEAEATTRLWELWYQQSFANGRADVKVGQQSLDQEFMVSQYASTFINATFGWPVLPAVDMPAGGPAYPLSSLGVRLRAKPSDAWTVMAGVFDGNPAGGVGDAQQLNRHGTNFNLRNGALFIGELQYALNAPPADPKAPQAGLPGMYKLGVWYNSERFADPRYDTNGVPLADPASNGVAATHRGNYGFYAVADQMVWRPGADSPRSLNVFARVMGAPGDRNAVDFTLNAGVTLKAPFAGRDNDTAGLAVSYAKIGSRARGADGDTGVFQTPGYPVRRAETLIEATYQYQVTPWWQLQGDFQYAFRPGGGIPNPNEPGSRIGNEAIVGVRTTITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YA9</accession>
    <name>Q63YA9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar brake protein YcgR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cyclic di-GMP binding protein YcgR</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ycgR</name>
        <name evidence="8" type="ordered locus">BPSL0279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interacts with the flagellar basal bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YcgR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197265.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106906.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0279"/>
    <dbReference type="EnsemblBacteria" id="CAH34267">
        <property type="protein sequence ID" value="CAH34267"/>
        <property type="gene ID" value="BPSL0279"/>
    </dbReference>
    <dbReference type="GeneID" id="56594370"/>
    <dbReference type="KEGG" id="bps:BPSL0279"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1426"/>
    <dbReference type="eggNOG" id="COG5581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REYFRVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071945">
        <property type="term" value="P:regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01457">
        <property type="entry name" value="YcgR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023787">
        <property type="entry name" value="T3SS_YcgR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009926">
        <property type="entry name" value="T3SS_YcgR_PilZN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07317">
        <property type="entry name" value="YcgR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="1 4" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T3SS_YcgR_PilZN" evidence="7">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="6">
        <location>
            <begin position="127"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="252" mass="27940" checksum="6ABE872DD75368B8" modified="2004-10-25" version="1">MNTEQSTSPAASAAAHSGHDYGRRNPLEIGVQLRNLVNRGDFLTVQYQGGQLVTRILDVDVGARTFVFDWGALADQNAGILAAPRCVFDASPDGVRVEFSTATPRETRYENLPAFEADFPDVLYCMQRREYFRVDAPILDPYVCRGRLPDGETFLFEVHNLSLGGLGLRTSDDRVASLEPGMTLPDVELNLNGHGMLSLDLQLVSHRASETPSGARRYQLGFRFVSLPGSAENTLQRIITQLEMKRRQLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YE4</accession>
    <name>Q63YE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009935977.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106871.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0244"/>
    <dbReference type="EnsemblBacteria" id="CAH34232">
        <property type="protein sequence ID" value="CAH34232"/>
        <property type="gene ID" value="BPSL0244"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0244"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1468"/>
    <dbReference type="eggNOG" id="ENOG50345QQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFQQRTT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266670" evidence="1">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="19511" checksum="A21C397BD848BB69" modified="2004-10-25" version="1">MIPFKRKMFASPASRPARAGKFVLEACFAGALAGAAHAQGAPQPVVDWEIQVVRDGQTIDAFEQKTTVGQARSDTHSLPIAPAAGCAATSAAASAADAPGSGLSRTITVAPLYVEDGAVALAIDAQETLADERATPPAGAPCTFALPRRIVASHPGLNARAAQWTDWTLAERNPQLVYRVRARVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YP9</accession>
    <name>Q63YP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549899.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106766.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0138"/>
    <dbReference type="EnsemblBacteria" id="CAH34125">
        <property type="protein sequence ID" value="CAH34125"/>
        <property type="gene ID" value="BPSL0138"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0138"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1583"/>
    <dbReference type="eggNOG" id="ENOG5033AEK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NMEFART"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007684">
        <property type="entry name" value="Znf_Ogr/Delta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04606">
        <property type="entry name" value="Ogr_Delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ogr_Delta" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="82" mass="9398" checksum="2AC56A349FB5DD69" modified="2004-10-25" version="1">MRILNRCPHCRTRATARSSREMSLTFREVTYQCNNPECGHTYVVNMEFARTLSPSGTPNLSLNLPLSPHVRERLAQQLELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS8</accession>
    <name>Q63YS8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phage portal family. PBSX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106737.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0111"/>
    <dbReference type="EnsemblBacteria" id="CAH34096">
        <property type="protein sequence ID" value="CAH34096"/>
        <property type="gene ID" value="BPSL0111"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0111"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.123"/>
    <dbReference type="eggNOG" id="COG4695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INDWVGD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030935">
        <property type="entry name" value="PBSX_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006430">
        <property type="entry name" value="Phage_portal_PBSX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018494">
        <property type="entry name" value="PBSX_VPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01540">
        <property type="entry name" value="portal_PBSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="370" mass="41641" checksum="E9F5FF9F77AEF86B" modified="2004-10-25" version="1">MSAVSGGLSSWRRRASTTASSACSNVTSSAATTLRNRPRQIRAPARAEVFTFDDPTPVMNRAEILDYVECWSNGEWFEPPVSFAGLAKSFRASTHHSSALFFKANVLASTFRPHRWLSRHAFERWALDFLTFGNGYLERRRNMVGGTLRLEPALAKYVRRKADFSGFVYVNGWQERHEFEPDSVFQLVRPDINQEVYGLPEYLSSLHSAWLNESSTLFRRKYYENGSHAGFILYMTDAAQKQDDVDNMRDALKNAKGPGNFRNVFMYAPGGKKDGIQLIPVSEVAAKDEFFNIKNVTRDDLLAAHRVPPQLLGIVPSNSGGFGTPDTAARVFGRNEIRPLQARFAELNDWLGDEVVRFDDYEIPPAPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YU0</accession>
    <name>Q63YU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197761.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106725.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0099"/>
    <dbReference type="EnsemblBacteria" id="CAH34083">
        <property type="protein sequence ID" value="CAH34083"/>
        <property type="gene ID" value="BPSL0099"/>
    </dbReference>
    <dbReference type="GeneID" id="56596734"/>
    <dbReference type="KEGG" id="bps:BPSL0099"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1632"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVDHICL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="138" mass="14937" checksum="3166B3429B56FEBD" modified="2004-10-25" version="1">MKFHIHEIDHVVLRAADLAAMTRFYCDVLGCHVEKEQRELGLVQLRAGRSLIDLLAVGAPIDRAGSGAPGKGRNMDHLCLRVEPFDAAALRTHLAAHGARPGDEARRYGADGYGPSLYLFDPEGNMVELKGPPEAVAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YV9</accession>
    <name>MNME_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">BPSL0080</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524586.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106706.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YV9"/>
    <dbReference type="SMR" id="Q63YV9"/>
    <dbReference type="STRING" id="272560.BPSL0080"/>
    <dbReference type="EnsemblBacteria" id="CAH34064">
        <property type="protein sequence ID" value="CAH34064"/>
        <property type="gene ID" value="BPSL0080"/>
    </dbReference>
    <dbReference type="GeneID" id="56596737"/>
    <dbReference type="KEGG" id="bps:BPSL0080"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1653"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000345744" description="tRNA modification GTPase MnmE">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G">
        <location>
            <begin position="226"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="236"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="255"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="467" mass="49453" checksum="F35C1452F4C71A0C" modified="2004-10-25" version="1">MLATDSDPIVAIATASGRGGIGVVRLSLGRAGEAAARALSDALCGARLMPRHASYVPFLDGAGEPLDRGIALYFPAPHSYTGEHVIELQGHGGPIVLQLLLQRCLDAGRAHGLRLAEPGEFTRRAFLNDKLDLAQAEAVADLIEASTEAAARSAGRSLDGAFSRDIHALVDDVIALRMLVEATLDFPEEEIDFLEAADARGKLAHIRERLAHVLGDARQGALLREGLSVVLAGQPNVGKSSLLNALAGAELAIVTPIAGTTRDKVAQTIQIEGIPLHIIDTAGLRETEDEVEKIGIARTWGEIERADVVLHLLDARSGLGPGDEAIAARFPDGVPVVRVLNKTDLTGAPASVTRTGGGAARADVCEVRLSAKRGDGIDLLRGELLRIAGWQAGAESVYLARERHLIALRAAQAHLARAAEHAEQNAQALDLFAEELRLAQERLNSITGEFTSDDLLGVIFSRFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV2</accession>
    <name>Q63HV2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112320.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2318"/>
    <dbReference type="EnsemblBacteria" id="CAH39804">
        <property type="protein sequence ID" value="CAH39804"/>
        <property type="gene ID" value="BPSS2318"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2318"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6775"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMACYMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="257"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="420"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="565"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="813" mass="90798" checksum="40708852F5FC89CB" modified="2004-10-25" version="1">MNGTSSMREQALGMNDGGGQAAELRPALDVWPILLMVSVLVCVVIVSLAVVSFLRVYIGGESTWSKSQKDAVIYLIRYAETGDERAYKLYEAAIDKPYRLSLARAALQRKPPDRASAREAIIASGIDPTDATAAALLLPALSWVAKINYALQCWMQADVELAEFRSVASQLHALVSSGHRDDARVKALEYRAWEINERVSGLPDRFSKAFSDEFRSSVALLLVCYFVASMFLMYLALVWARKAALQRLSIQYALDRSEAFAEAALSSVAEAVITVGLTKNVDFINNAAEQLLGYPAAACVGAPVSSVLMLLDKETGHAVDIVDEFWAREERTPIKREVHLLRRDHSKIVVQTTISEMGDRVHGHIGYVLILRNMTREQQFLESLAWQATHDVLTGLVNRVEFERRLEIALADTASGKERADSMLLMLDLDRFKEINDTCGHAAGDAMLREVTQRFQSCLDDDDVLARLGGDEFGVLLPHGAGSWPSKNKAERLRRSLEDFVFLWEGERFTVSVSIGVLELCKAPRNLEMAVKLADIACYIAKERGRNRIQLADPSDLQQARHVGDVQWSRRIKTALENDGFRLYVQPIVHTRPDSRTPERAEVLLRMMDSAGRDISPAAFLPAAERYGLMGLIDRWVIRTVFRKLSALPAREYHEYNVNLSGASISDERFLEFVIAELLSSGLEPSVICFEITETIAVKNLELASRFMGELRTIGCRFALDDFGAGMSSFRYLRSLPIDYLKIDGEFVSNMMSDRVSYGVVSAINEVAHSMRCSTVAEHVESEVELAMLRELGIDFCQGYFFAQPSPWREGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I20</accession>
    <name>Q63I20_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sigma-54 interacting response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187694.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112252.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2249"/>
    <dbReference type="EnsemblBacteria" id="CAH39735">
        <property type="protein sequence ID" value="CAH39735"/>
        <property type="gene ID" value="BPSS2249"/>
    </dbReference>
    <dbReference type="GeneID" id="56598356"/>
    <dbReference type="KEGG" id="bps:BPSS2249"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5851"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APMISVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="141"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="456" mass="49766" checksum="C0C47BD4CF9DA62C" modified="2004-10-25" version="1">MPYILIVEDDADTRDMLCALAHTQQLACDAAATLEEARALIATHTPDLVLCDLVLPDGNGMDLFDELPKGAHVEMVLTTGHASLETAIDALRRGATDYLVKPLNMQRLNSIFARVPRTGVLHEEIAALRSELQRLGRFGRMLGRSPVMQTMYDAIGRVAGTEASVLLMGESGTGKELAAQTIHDLSLRRKGPFLAVNCGAIAANLVESEMFGHDRGSFTGADRQHKGFFERADGGTLFLDEITEMPVESQVKLLRVLETGRLTRLGSARELDVDVRIVAATNLDPEAAMADGKLRPDLYHRINVFPITLPPLRARGDDIPMLAEAFLRQLGEDSGRKMRFSASALAALAEYDWPGNVRELRNFVQRACIFNDGEVIDTLPPPIMDEVASEPGDDGDAVTVPFGTSLEEVDRRIILGTLAQCGGVKTHAAEVLDISLKTIYNRLAQLEAEGDDKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I80</accession>
    <name>Q63I80_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205741.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112192.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2190"/>
    <dbReference type="EnsemblBacteria" id="CAH39675">
        <property type="protein sequence ID" value="CAH39675"/>
        <property type="gene ID" value="BPSS2190"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2190"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5773"/>
    <dbReference type="eggNOG" id="COG4964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TELMIMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032789">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13629">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266454" evidence="3">
        <location>
            <begin position="39"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="T2SS-T3SS_pil_N" evidence="4">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="690" mass="67990" checksum="39C7441E629A8910" modified="2004-10-25" version="1">MDTKPQLSRPTPARSRAVRGAALAAACCAGLFTVFAAAAQDAVENAAIAKGTAAAPMALGRAPMQMTISMAPAPAAGAAAAAAAVPLRGPSCVGEMRESTSVSVPLGKSLLVPLDEPVRNRTIGNPAVAQATMVSPRTLYLVGMSVGTTNMIVQGKSGACRIIDVAVGADAGGLQASLRQLMPRERDIRVSTAADTIVLAGNVSSAQAAQQAVAIAKAYSNRTNAGAAGSGGGARADVLNMLTVTSPQQVMLEVKVAEVSKTLINQMGSAVNIQGGFGSWTGALVTSLLTGVGSGIAASKSNKLPLNGSIDAQNTDQPVKILAEPRLVTISGQEATFLAGGKIFIPVPQSSGIGTNTITLQEEEFGVGLKFTPTVLSNGRISLKVAPEVSELSPTGVTLSAANVGNVSILPLITTRRASTTVQMGDGETFAIGGLIKDNAQGTLKALPGIGELPVLGALFRSTSFQQDRTELVFIITPHLVQPLETADVPLPTDSFTKPNEADVYATGNMEGRGGLRQHGAAPAAAPANAAPGAAAPTGAAPAAAVPAPAAPAPAAPAAPAAAAAPAKDAAASPAPAKQAPIAAQAPAPQPAKPAASAPAPANARPPATVQAPPPALPSAAALAQRQGAHAAAPDTAHAGPAESAAATASPAPAAALAAPAAAGATAKRQGAQPPQQLANAGAIAPAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I82</accession>
    <name>Q63I82_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529404.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112190.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2188"/>
    <dbReference type="EnsemblBacteria" id="CAH39673">
        <property type="protein sequence ID" value="CAH39673"/>
        <property type="gene ID" value="BPSS2188"/>
    </dbReference>
    <dbReference type="GeneID" id="56531723"/>
    <dbReference type="KEGG" id="bps:BPSS2188"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5771"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EKFEVPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="180"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="460" mass="50336" checksum="E73C71DD514C7FC6" modified="2004-10-25" version="1">MNLDQAEPRHDAQIAHLPEPPSLRTYRARQAPRLPAAPRTLAETGLDEAFVAALLLKSMLAHGRSSLTEIVARHGLPPAVLDEVLTFLACERLIEVTHRGLSDIDLTLRLTELGRALALEEKARNSYCGPAPVTHEAYVASVTAHSVRHVTIARADAHAAFDGIVVEPAMLDAAAASLNAGRPLLIYGPAGSGKTYLAERLGSLLRGNVPIPYAIYASGEVIKIHDPLVHVDAPRAADGANGDRRWRLCRRPIVLSGGELTLAELDLRRDDSTGYYQAPPHVKANTGIYIVDDLGRQRIAPRDLLNRWLLPLDRNVDQLTFASGVRLEMPFDVWPVFSSNLTPAQFSDDAFLRRLGSKLHVGPLPAGRYRDVYDANCAALALSSDASTFDYLLQHLHGPTRMPFLACYPGDLLRLVAASVRYRGDAPTVTPQALHEAWRSFFGSAPDEPPFNPPDADRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IA9</accession>
    <name>Q63IA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546306.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112163.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2162"/>
    <dbReference type="EnsemblBacteria" id="CAH39646">
        <property type="protein sequence ID" value="CAH39646"/>
        <property type="gene ID" value="BPSS2162"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2162"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5734"/>
    <dbReference type="eggNOG" id="COG4645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTMAGRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014550">
        <property type="entry name" value="UCP028704_OpgC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38592">
        <property type="entry name" value="PTHR38592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10129">
        <property type="entry name" value="OpgC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028704">
        <property type="entry name" value="UPC028704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="375" mass="40369" checksum="D1C837D123849C12" modified="2004-10-25" version="1">MSVDAMASPALAGRSIEVDFFRGVVLLTIVVDHIGASVLSRVTLHAFALCDAAEVFVFLGGFATASAFLSVSARHGAGAARRRFMRRAAQIYRAFLATSTLMLVVSAVLDHYGIDAPNMALDDISVLLASPLTVLVELLTFKRQPYLASVLPMYVLFALATPAIVPLARAKPWWLVFGSVLMWGCAPWLAAQLLDTESFRWSFNPFAWQLMFVFGVLMRCWPLHRDAATRAGGTAITAVALAVVLACAYYKLGSGLPLPEGEFKRHLAWPRVMNFAAFAWLMAELVRYGWIARLARAARPVVAVGQRGMLCFVAGAAISLTLDSVLHGMHGGARMMQLGAGLAADACALALMLSIARSDLLLQRLRRASAAAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC0</accession>
    <name>Q63IC0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Acyl-CoA transferase/carnitine dehydratase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112152.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2151"/>
    <dbReference type="EnsemblBacteria" id="CAH39635">
        <property type="protein sequence ID" value="CAH39635"/>
        <property type="gene ID" value="BPSS2151"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2151"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6557"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATYLGEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="433" mass="46202" checksum="1BFEFD13F4EFAC49" modified="2004-10-25" version="1">MAGAHEAFRPTSRLENTMTNVNVDVDLDEPRAQGRTHASAAPPLDGIRVIDAATLFAGPLAATMLADYGADVIKVEHPTGDPARKYGARRDDVPLWWKVIARNKRSVTLNLGHADGQRLFRELAATADVVIENFRPGTLERWGLGYDVLSALNPRLVLVRVTGFGQFGPYASRPGFGTLAEAMSGLASVTGEAGGAPLLPSFPLADTIAGLNAAFATLTALKARERTGRGQVVDLAIIETMLAALGAQIASYDQTGVVPPRTGNRSPNNSPRGVYRSSDGKWVALSTSAQSIAERVMRLVGRADLVDEPWFATGAGRARHADELDAAVGGWIAQRTRDEAIAEFERAEAAIAPIYDVADVLRDPQYAALGSIVTLRDEELGAFRTHNVPFRLSDTPGAIRWGGPRRGAHNDEVFGALGIDADELADLTERGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IM8</accession>
    <name>Q63IM8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529287.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112044.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2041"/>
    <dbReference type="EnsemblBacteria" id="CAH39519">
        <property type="protein sequence ID" value="CAH39519"/>
        <property type="gene ID" value="BPSS2041"/>
    </dbReference>
    <dbReference type="GeneID" id="56531839"/>
    <dbReference type="KEGG" id="bps:BPSS2041"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5573"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GSDFPNI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="64"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="38209" checksum="4DFA3C265341FDA6" modified="2004-10-25" version="1">MTTLRIFDARVHVLPDVVAKLVWKNYARDAWKIRYELLAEQSIAFLKAHGVARAAGICYAGQPGIAPFLNDFVAQLASRHPAFLVPFGTVHPHDRDAARETARALDELGFAGLKIHCHLLKIAPDDDALAPIFEALAERGKVLNLHSGAFAKNNAQMDEIRRFCNVERFRRAMRRTPELKVVVPHIGYDEVQAYLDLLDEFPNLHFDTAMAFGGHRIATGEAVPDVRPLRETRYPRGAHPRLPAPWKPALEQLVPQMRDRPDRFLYGSDFPLIPYDWDVEIEQLKRYLPADVLRKVLWDNARALFDGDAHRASDANDAGAHEDASAAAPVSAGQPATEPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IS7</accession>
    <name>Q63IS7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552130.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111995.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1989"/>
    <dbReference type="DNASU" id="3096101"/>
    <dbReference type="EnsemblBacteria" id="CAH39467">
        <property type="protein sequence ID" value="CAH39467"/>
        <property type="gene ID" value="BPSS1989"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1989"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5494"/>
    <dbReference type="eggNOG" id="COG3369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESHYARF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="384" mass="41464" checksum="138DF959F00BBAD4" modified="2004-10-25" version="1">MNPNTVPPAARDVAWIKHALQTAIELEYSTLPLYLSAMFSLEVQNYTAYNAIRSIAMEEMVHMAIAANLLAALGGSPQFKPIQIAYPTTGLPGGAEPDLHVGLARYSKPQLKNFLRIETPGFLLRQLGRDEGYPTIAAFYESIRSAIARNANAVRAAVQAGGPANQVGDDIGFTTVTYKPGVDPVESFDAGIGEILQQGEGSGRGDVFAGNPFEDEESHYARFAELYYGARYQAPSPPVDFNPKNEPLFFGGPAIAAPVVVNTLAVPRDGYARILALDPERDTVESDLNAFDSGFSKILSTLDAVWNGPSSTSWKTLGAAVHGMVDLRVLSCFNIMRHAVPAAAVSQLAELYPDEIGFLRTYTDLSKPVFYGPRFVNVNGKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JA1</accession>
    <name>Q63JA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525102.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111821.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1817"/>
    <dbReference type="EnsemblBacteria" id="CAH39293">
        <property type="protein sequence ID" value="CAH39293"/>
        <property type="gene ID" value="BPSS1817"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1817"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5262"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHPYAID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="17415" checksum="1E3A05F78CC8E46A" modified="2004-10-25" version="1">MNTSTDRIEKRIVLNAPRSRVWRALTNADEFGAWFRVDLAGQTFEAGRCVEGRITYPGYEHLVLRMRIERIEPEHRFSYHWHPAAIDPAVDYAQETPTLVVFELADVAGGTLLTVVESGFDKLPIERRAEAFRMNDGGWGEQMTNIAAHVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JD7</accession>
    <name>Q63JD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940978.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111785.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1781"/>
    <dbReference type="EnsemblBacteria" id="CAH39257">
        <property type="protein sequence ID" value="CAH39257"/>
        <property type="gene ID" value="BPSS1781"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1781"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5221"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MMVLWER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="16910" checksum="5C5896A0C710990F" modified="2004-10-25" version="1">MNDSPTFPLTLDDQLCFALYSTSLAMTKAYKPLLDKLALTYPQYLAMLVLWETDDMAVKDIAARLSLDPATVTPLLKRLEALGYIERVRDTNDERIVHARLTADGAALKHKARAVPAELFCAMRQTPDFLIRLREDLTRLRQALTDADDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JF4</accession>
    <name>DXS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="1">DXP synthase</shortName>
            <shortName evidence="1">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs</name>
        <name type="ordered locus">BPSS1762</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266656.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111768.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JF4"/>
    <dbReference type="SMR" id="Q63JF4"/>
    <dbReference type="STRING" id="272560.BPSS1762"/>
    <dbReference type="EnsemblBacteria" id="CAH39237">
        <property type="protein sequence ID" value="CAH39237"/>
        <property type="gene ID" value="BPSS1762"/>
    </dbReference>
    <dbReference type="GeneID" id="56598188"/>
    <dbReference type="KEGG" id="bps:BPSS1762"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5193"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000256390" description="1-deoxy-D-xylulose-5-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="634" mass="68281" checksum="AD3B0D6BE0BF9DC9" modified="2004-10-25" version="1">MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQTYPHKILTGRRDGMKTLRQFDGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSKLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEEFGFNYIGPIDGHDLDSLIPTLQNIKELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSTTPAKKTYTQVFGEWLCDAAELDARVVGITPAMREGSGMVEFEKRFPERYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFLRCIPNMTVMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVATVKAFTEIPLGKGEVRRRTSQPDGKRIAILAFGTMVAPSLAAADALDATVANMRFVKPIDAELVQALARTHDYLVTVEEGCVMGGAGSACVEAMMESGAVRPVLQLGLPDRFVDHGDPAKLLSLCGLDGDGIAKSIRERFLSHAADVASPAKRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI1</accession>
    <name>Q63JI1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552009.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111741.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1735"/>
    <dbReference type="EnsemblBacteria" id="CAH39210">
        <property type="protein sequence ID" value="CAH39210"/>
        <property type="gene ID" value="BPSS1735"/>
    </dbReference>
    <dbReference type="GeneID" id="56529852"/>
    <dbReference type="KEGG" id="bps:BPSS1735"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5161"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WMRALKN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="29866" checksum="1BE8631119A78505" modified="2004-10-25" version="1">MKLLAKPLFAPHMSGLERAWYFALRGLVVLTLLYLILPVLAIVPLSFSSSTFLVYPIPGFSMRWYENLLASDEWRMAAKNSFIVAPAATLVATVLGTLAAIGLTKSDFRGKGLLMAVLLSPMIVPVVVVGVGMYLFFAPLGLANTYTGLICAHAALGVPFVVTTVAATLQGFNQNLVRASLSLGANPVTTFFRVTLPVIAPGVMSGALFAFATSFDEVVVTLFLAGADQTTLPRQMFTGIRENISPTIAALATILIVFSTCLLLALEWLRGRHAKRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JK1</accession>
    <name>Q63JK1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltA</name>
        <name evidence="9" type="ordered locus">BPSS1715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188362.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111721.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1715"/>
    <dbReference type="EnsemblBacteria" id="CAH39189">
        <property type="protein sequence ID" value="CAH39189"/>
        <property type="gene ID" value="BPSS1715"/>
    </dbReference>
    <dbReference type="GeneID" id="56598072"/>
    <dbReference type="KEGG" id="bps:BPSS1715"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5132"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="433" mass="48533" checksum="8F02A60A6145BA2F" modified="2004-10-25" version="1">MTPSDVKATLSFSDNSPSVELPIYKGTMGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSAITYIDGDKGELLYRGYPIDNLAQNADFLESCYLLLKGELPNAAQKKEFVATVTKHTMVHEQMQFFFRGFRRDAHPMAILVAAVGALSAFYHDSLDINDPRHREVSAIRMIAKLPTLVAMAYKYSIGQPFVYPRNDLSYSANFMRMMFANPCEEYQVNDVLVRALDRILILHADHEQNASTSTVRLAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLEQIGTPENIPEFIKQVKDKNSGVKLMGFGHRVYKNYDPRAKLMRETCYEVLNELGLHDDPLFKLAMQLEKIALEDEYFVSRKLYPNVDFYSGIVQRALGIPTSMFTCIFAMARTVGWIAQWNEMIADPEQKIGRPRQLFIGETPRTAKPIEQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JM0</accession>
    <name>TRPA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="1">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpA</name>
        <name type="ordered locus">BPSS1697</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528976.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111702.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JM0"/>
    <dbReference type="SMR" id="Q63JM0"/>
    <dbReference type="STRING" id="272560.BPSS1697"/>
    <dbReference type="EnsemblBacteria" id="CAH39170">
        <property type="protein sequence ID" value="CAH39170"/>
        <property type="gene ID" value="BPSS1697"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1697"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5109"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000098761" description="Tryptophan synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <sequence length="271" mass="27978" checksum="AC4B9137254195CD" modified="2004-10-25" version="1">MSRIQNTFAALAAQGRKGLIPFITAGDPDPAKTVELMHALAEGGADVIELGVPFSDPMADGPVIQRSSERALAKGVTLHSVLDDVKRFRARDQKTPVVLMGYANPIERMGADAFAAAARDAGVDGVLVVDYPPEESHDFAAKMRAAGIDPIFLLAPTSTDDRIAAVGQVASGYVYYVSLKGVTGAANLDVSSIAGKIPAIKSRVPLPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLLEQAAPERAAAELAGFVAELRVAIDGAAKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JM8</accession>
    <name>Q63JM8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525198.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111694.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1689"/>
    <dbReference type="EnsemblBacteria" id="CAH39162">
        <property type="protein sequence ID" value="CAH39162"/>
        <property type="gene ID" value="BPSS1689"/>
    </dbReference>
    <dbReference type="GeneID" id="56529900"/>
    <dbReference type="KEGG" id="bps:BPSS1689"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5101"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KLAMEHM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="322" mass="34886" checksum="0F516DDC29A7FC16" modified="2004-10-25" version="1">MRPSEPGARRALVTGIAGFTGRHLAARLEAHGYDVWGTVAPGTDVLGDPLLRRWRCVKADLLDVDSLHAAVADARPHAVVHLAARAHVAHGNPQDTYLVNVVGTRNLLASLAGLDARPHAVLLASSANVYGNASTEVLDESAPPQPANDYAVSKLAMEYMAKLWLDRLPIVIARPFNYTGVGQSEAYLLPKLVAHYARGEPRIALGNLDVSRDFSDVRDVVDAYARLIDAAPVGETFNVCAERGYALKEVLAMLARIAGYVIDVSVDPRFVRASEVKKLVGSRRKLRAAIGDARRTPLDETLRWMYGDMRAALGAREDQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JU4</accession>
    <name>Q63JU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525254.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111628.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1620"/>
    <dbReference type="EnsemblBacteria" id="CAH39095">
        <property type="protein sequence ID" value="CAH39095"/>
        <property type="gene ID" value="BPSS1620"/>
    </dbReference>
    <dbReference type="GeneID" id="56529968"/>
    <dbReference type="KEGG" id="bps:BPSS1620"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5006"/>
    <dbReference type="eggNOG" id="COG4789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PQFIGLQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006302">
        <property type="entry name" value="T3SS_HrcV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01399">
        <property type="entry name" value="hrcV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="690" mass="74131" checksum="C695E303CF7F335F" modified="2004-10-25" version="1">MTLKSLKLPAGGEVGITVLVVAIVSLMILPLPPEVIDVLLGVNIAISVTLLMVTMYVGSIVSLSVFPSILLFTTLYRLSLNIASTKSILLHANAGDIIESFGELVVGGNLVVGLVVFLIITIVQFIVIAKGSERVAEVGARFTLDAMPGKQMSIDADLRANILTPDEARRKRATLAKESQLHGGMDGAMKFVKGDAIAGLIITLVNIVAGIAIGVMYHGMTAGDAANRFSILSVGDAMVSQIPSLLISVAAGVMITRVADDHDDGDGTSLGSEIARQLGGSHRALYFAAVLLIGFAAVPGFPAALFVLLSGMLAFAGYRLQKGARRTTARGEPVIALQRAGAKSSTPSILPRAPLFTCAIGVRVAPDLVARLAPAALDRAFDEERAKLQEEQGLPFPGITLWTSDALPASTCEILMRDVPQARLELPADQTMLPDAASDPALAGRCTKRGPAGGLAESYWIDDKAVPAGARAWRAEQVVAHETIALLRRNAHLFLGIQEAQWILDQLGVDYPGLVAEVQKALPTQRIADVLRRLLEEHIPIRNARDIMESLVAWGPKEKDMLMLAEYVRGDLSRYLAYRAARGARQLPAVLLDMAVEQHIRQSIKQTPAGNFLALPPEQVRYLVDSVASFVGEAPRDDVALVTSMDVRRYTRRMIEARLDWLPVYSYQELGDQVQLQPVGRVTMPTAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JV6</accession>
    <name>Q63JV6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111616.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1608"/>
    <dbReference type="EnsemblBacteria" id="CAH39083">
        <property type="protein sequence ID" value="CAH39083"/>
        <property type="gene ID" value="BPSS1608"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1608"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5890"/>
    <dbReference type="eggNOG" id="COG1670">
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    </dbReference>
    <dbReference type="OMA" id="IKEGMFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="220" mass="24728" checksum="468D1BC5AEC05A15" modified="2004-10-25" version="1">MRGRARQSVRFPMTEEPPMNAFRPPELIETERLRMRPLTEGDAPEAFDALFGDRATTLDLPWPVHRSVDESRASIRRLAEGWRSGAFFSWGLFEKRGGRLIGTLEMHGRLPRVEIGLLTSFAPGRVRTRAWSEMLHRFLGWLIAQPGVYRIEAFCSVTGKAAPLMPHFGFVCEATVRNYEARPNRGMSAGDSYLFAITKAPQALRGAVEDEARAPSRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW1</accession>
    <name>Q63JW1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205651.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111611.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1603"/>
    <dbReference type="EnsemblBacteria" id="CAH39078">
        <property type="protein sequence ID" value="CAH39078"/>
        <property type="gene ID" value="BPSS1603"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1603"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4985"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YALDMRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266521" evidence="2">
        <location>
            <begin position="21"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="3">
        <location>
            <begin position="178"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="601" mass="61548" checksum="23AD0DC13C2E70CC" modified="2004-10-25" version="1">MTRRAAASAAAVALALASHAAALRAVPLAWPLARFDYRVGPVNAADALGELSRRSGIAIDVDARAPCRLDVREALPPRRFVERLARTCGLVSYYDGAVLQLVAPDAFEHAAVRLNYATLAELRAALARQRIVDARWRPGYDDAARIARVAGPPRYVALVLAAARALDEAAQTRVRTETRAFRLRARAAADRVVRGDGDGDDAVLPGLATRLRRRLEQDGAAPRAVPGVREFTASLPIVDADARSNTVLIRDVPARLARDARLVAQLDTRPASIRIDAFGATLAPAQLDALGLRWRDGALASGASRDAGVARDGSRASVGVRPVGASRPSGARNEAAAAGARRAPAVSAAPDASGASAASGPSGPSAASGAPDAVDASAGSADSPRASAVRIAIVSTPAGCAPVRARIAELAAHGDASIDADDSTLALPDSRADFGRLRLSFVASGDGDARALDARRNGFAMRVTPHETAQPARYALDIRIVERRADGDAAGASSRETVAGVMLAAGECAALALPSAAHGEQRLVLVTPRTVPADPARLPPQASPNAPAAAAAAVAANARGPDTAEPAARAHAAARAHPPAAALPSPSAGLGLRAQTRLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JZ4</accession>
    <name>Q63JZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of taurine ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tauC</name>
        <name evidence="6" type="ordered locus">BPSS1572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111578.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1572"/>
    <dbReference type="EnsemblBacteria" id="CAH39045">
        <property type="protein sequence ID" value="CAH39045"/>
        <property type="gene ID" value="BPSS1572"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1572"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5845"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIEFYRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="29715" checksum="7D4392A559874FCD" modified="2004-10-25" version="1">MTLAATEPNADLALPLPATHAAASAAARRAPRVHAGHAAALATWVALAAGWWLAARFEWVSAALLPGPEAVLRKLVVLSTEGFDDATLGEHLLASVSRIATAFALAIVTAIPVGILVATNRIVRGVVDPIVEFYRPIPPLAYLPLMVVWFGIGDASKILLIYLTMFAPLAIATAAGASGVSESRLRAAASLGATRVQLLRHVVLPSALPDILTGVRIALGAGWSTLVAAELIAATRGLGFMVYSASRFLVTDVVIAGILVIGAIALALEIGLRALQRRLTPWRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K27</accession>
    <name>Q63K27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205638.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111545.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1539"/>
    <dbReference type="EnsemblBacteria" id="CAH39012">
        <property type="protein sequence ID" value="CAH39012"/>
        <property type="gene ID" value="BPSS1539"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1539"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4894"/>
    <dbReference type="OMA" id="PARTHDP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="425" mass="43160" checksum="3A3775A676E6B04A" modified="2004-10-25" version="1">MGSTISNSAPIAPIVSGVEPAQQPDAGRTSDLQRAYHEQCRAALGKRDDGRDCDDTEAQRAHARKKTKRNGEPPGAAGGMPVPHAARDRAFALRFGGARLGEARSGANARDARVGAGAEAGIEAGIEAGVGVGTDAHAAGGARTRGEIAARGGATMRGHAPASGAVRATSERAPAAATADAHAPQAAAESAPPSVPMPAAHAAPRTSGGSARDIAAAAARICATAADPAAGVVASRSPALPAARGPASATAAASAMSAMSSTRRPTAAASPGAARERVDGDDSNRAGDASLAGLPRGVQPQASLRAAEPAARAHDPSRAARQRAQAGAAQADARDVRETQGTQVRYSFNSWDGRPAVELRFDAGGAPRVVNAQPSHDRVQRAMEHGADRLSPGWTVEFDRSRADDDSGGRSPWRRARQEPEADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM3</accession>
    <name>Q63KM3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528643.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111348.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1338"/>
    <dbReference type="EnsemblBacteria" id="CAH38809">
        <property type="protein sequence ID" value="CAH38809"/>
        <property type="gene ID" value="BPSS1338"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1338"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4638"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IDWANFT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="14082" checksum="DD7B379154DAD922" modified="2004-10-25" version="1">MAVDLVHFTPGLSFAGGLLIGAAAALLVFFDGRIAGISGIVGGLLAGGRSDAGWRAAFLVGLIAAAVAASALDWFSMPAVDAGWARVIAGGVLVGIGTRYAGGCTSGHGVCGISRGALRSIVATAVFMAAGIATVFVLRHVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP0</accession>
    <name>Q63KP0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111331.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1321"/>
    <dbReference type="EnsemblBacteria" id="CAH38792">
        <property type="protein sequence ID" value="CAH38792"/>
        <property type="gene ID" value="BPSS1321"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1321"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5534"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLMGHDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="193"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="39642" checksum="BD3DA00DC692AC67" modified="2004-10-25" version="1">MRIDRIGAFQFHPIQPIKADIVLRRGLCNLKTRKGVAMQNVDRPTGSSLAGAAILLEIGAAYGIVDFIRHSNGFDVAALAERSGIGEPMIADYVDAMREAGLVTLAKAGERDIYRPADDFPDVVNDVGYLSWALLACAPLIVNAREFAADNALAQARHPRDGGLVARTSKWMGELSFYPQPERAILKLRPKKIVDLGSGSGGFLIRMLHQLDGARGVGVDLSATATEQAKQAAEANGFAGRLEFLHRPIQSLVDDPAPLKGADVVHAGFVMHDLLPAEERTLDALLETCREHASSGTVVIVDAVPLAPDRWERSFAAAFNHLHRNFMSRRLLSEDAWREKFEQAGFGNVAVETLGHPGGRMILGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KW0</accession>
    <name>Q63KW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111261.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1253"/>
    <dbReference type="EnsemblBacteria" id="CAH38720">
        <property type="protein sequence ID" value="CAH38720"/>
        <property type="gene ID" value="BPSS1253"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1253"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5441"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HLLWNRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="312" mass="36146" checksum="4265DD2BD639BF2A" modified="2004-10-25" version="1">MMDRLDWNLLRTYLTIMQERSISRAAARLHLTQPAVSQALKRLEDSLGRTLIQRRGAQFQPTRAGEEVYRIATDIYGHMSRLDNELDDRGGELIGSVRLLCVSRVESPVYDEFLAEFRRTYPRVDLHVEVMRSADILSSLLQKTATCGLALCRTPVDKIELRSFLRQRYAMFCGRHHRLFGRQALKIEDLLAENFVSFTSDQIGDALAPLTVFRDQRGFTGRIVATSPSLDEIRRLVFAGYGIGCLPEHIVRDDLARQRLWRLPPEEGLLDVEIFLMWNRERRMNAAENVFIDAFQRYVQRYPMAERLGMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L24</accession>
    <name>Q63L24_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528421.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111197.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1184"/>
    <dbReference type="EnsemblBacteria" id="CAH38652">
        <property type="protein sequence ID" value="CAH38652"/>
        <property type="gene ID" value="BPSS1184"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1184"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4416"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHVEVPH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="98" mass="10289" checksum="4FB38AFC2638AAF4" modified="2004-10-25" version="1">MTPHVEVPHVQRIDHAVLAVVRAVLDRPDAAMNDAFLSIGGSLQAAQRVVAQLQHRLCADIAPHLLLNSACIGDFADTLARTLNGAPGDACAPPPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L35</accession>
    <name>Q63L35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative non-ribosomal peptide/polyketide synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537462.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111186.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1173"/>
    <dbReference type="EnsemblBacteria" id="CAH38641">
        <property type="protein sequence ID" value="CAH38641"/>
        <property type="gene ID" value="BPSS1173"/>
    </dbReference>
    <dbReference type="GeneID" id="56530413"/>
    <dbReference type="KEGG" id="bps:BPSS1173"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4404"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVANLRN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1401"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1474"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1485"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1530" mass="162837" checksum="2863BA4686B0EAC0" modified="2004-10-25" version="1">MEQVALIGSRLRLPGADTVDAFWQNVLAGRDCIDSLSDAQLLAAGVDPAFSGLPDYVKRAGVLADVDRFDYRFFGYTFREAQAIDPQQRVLLTLAHQLLEQVGAPGRDVGVYTSVGFPHYLLNNLSTQPPGRVALSDVVFGNSGDCASTRIAYKLDLHGPAMSIQSGCSSALMALHNARIAILTGQCRMALVGAAAIRTPQTEGYLYQRDGVLAKDGVCRPFDARASGTVFTNGAVVLALKALSAAQRDGDDIIGVIRGSAINNDGQRKSGYTAPSVAGQSEAIRRAYERSGIGPETIGYVETHGTGTALGDPIEIQALKDAYGGDAGVGARARCALGSTKANIGHTDVAAGLAGVLKAALCVKHAIKPPLAGFERANPNLPLDGSPFYIPSTPEPWPNAEGQPRRAAVSALGVGGSNAHVILEQAPQRDLSRCVDTGPLLMSAQTPHALDALDAQYDDAFARQVLPRGDACYTSQLFRRHLPEKRAFVFDAAGGRRRVAPSGDWRHAHAALLFPGQGTQYAGMGRALYARGGQFRATFDDCADRFVREGCADPRELLNADDARIRDTAVLQPYLFTLEYALGATLLAMRLPVAAAIGHSLGEYVAATLAGVFDLADAIAIVAIRARIMSRAPRGAMLAVLAEEARVTAFLDEALSLCAVNSDTSCVVGGTEQAIDALAARLAGAGLASVRLQTSHAFHSHLMEASSREFAAAFDGVPLRAPRFPIVSNLDGRADLPERFATAGYWVDHLRRPVRFNDGLATLASLVPFGAWVEAGPGKSIANTLARMPLTEVACLSTMLPGSETALFDTLAAQCWANGIEIDWTPLYGDTRGNVVPLVPHPLDEISCWIDAPAKRAVAGEAPEYEKQGDIDQWFYEYDWAPVQPDGEAAPGHAAARAPIADSVLLIGDASRDAARLAERVAQDAESFFVVDGAHPQALDGALATVAAQAAAKRVRISRVLIVVPSRRGGADTQADGARDESGCALDAMLAMQRTFDALRNALPGKLDVALIALSGARGDGGEPSVASAWIDSFATVVHQEFSRVVCRAVHVDAAPAAGEADDAAARRCTIDTLAHACLRHPGRFLRIRDGRLIERGLKRGGARAANAHLAPDAPDATPKSPRTVLVVGGAGNVGMIYATFFATVVGADVAIVSRRARAFADSLRDPSAATDRALRRRKALYERMVAAGGRLMFVDADATDPRQLERAARSVADAFGSLDLVVHAAGAPADMHYRTFDDTDVAYLDALVSPKLDVCANLHALTRSLRIARVMIVSSISATLGGIGLYGYAASHSLLNAYAQSASSAACRWTVIDWDAWEFFKDTRDEANDDVGIDHYAISEQEGLSVLERLHALGWPAHIVVASGDLIQRYRNWVLSERDDTPAAAQIVAPRPLLKDELVAPRTGTEAALAKLWSECIGVEPVGVRDNFFELGGHSLIALKLVDRINQTLDWDLSAVDMFKFPTIERLADANAAHAPGDADDAGAPRGAGHDARDDAPRPPAQPDAGAHADRRRRHYYQSRKHSMESKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LS6</accession>
    <name>Q63LS6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551609.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110945.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0936"/>
    <dbReference type="EnsemblBacteria" id="CAH38399">
        <property type="protein sequence ID" value="CAH38399"/>
        <property type="gene ID" value="BPSS0936"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0936"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7238"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECPYVWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="442" mass="46997" checksum="24A42E294209AB90" modified="2004-10-25" version="1">MTTTYPLYKTLARADEPFPAQADVVIAGAGIMGCAAAYYLGLRGIKAAVFDKSRIAGQQSTRAWGFVRQQGREAAEVPLMMAGMRLWEGLERELGADLEWRQGGCLYLADNDDDWASFRQWMDVARAHGLDTRTLARAEIDAHVSGLAAPALGGLYTASDGQAEPRRVAAAFAARAIEAGARFFEGCGVTAIDTSGGAVAGVVTERGVVKARRVICAAGATSFRLLDGVGIRLPQQAVRGTCMRTNPLPAVSASTIWGHGLGIRQRANGAINLADDMQVDVDVTLGHLRGLSLFLPELWARREKFRFHLNGAAWRDLKVRAAGGAAVLEPRDPNPQPNPAHAPRALAKLKAVFPALRDARIVEAWAGLIDVLPDGIPVIDAPRAPDGLAIATGFCGHGFAMGPIVGSLLAEWVDTGATSLDLSAFRAARFVDGTMRRPASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LW0</accession>
    <name>Q63LW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative thiamine pyrophosphate enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524004.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110911.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0902"/>
    <dbReference type="EnsemblBacteria" id="CAH38364">
        <property type="protein sequence ID" value="CAH38364"/>
        <property type="gene ID" value="BPSS0902"/>
    </dbReference>
    <dbReference type="GeneID" id="56530643"/>
    <dbReference type="KEGG" id="bps:BPSS0902"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7195"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKGAFPW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="197"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="387"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="557" mass="59219" checksum="CEFBDA4E30C1B30A" modified="2004-10-25" version="1">MSNPTTTTVGELIAAFLEQCGVKTAFGVISIHNMPILDAIHTRGKIRYVGARGEAGAVNMADGLARVSGGLGVAFTSTGTAAGNAAGAMVEALTAGTALVHITGQIETPYLDQDLAYIHEAPDQLSMLNAISKAAYRVRTVETVLPTIREAVRVAMTAPSGPVSVEIPIDIQAAEIEWPDDLAPPHVAVREHDSARVAQLAERLAGARRPLLWLGGGARHARAEVERLVALGFGVVTSVQGRGVLPEDHPATLGAFNVHAAVEHFYKTCDAVVVVGSRLRGNETLKYKLALPRPLFRVDADALADNRGYRNDLFVHGDAKRVLAELADRLEGRLAIDPRFADDLAAARAAAVADVGKGLGPYKRLVDTLQQALGRDYNWVRDVTISNSTWGNRLLRIFEPRAGVHALGGGIGQGMQMAIGAALAGNAAKTVCLVGDGGLMVNVGELATAVQENANVMIVLMNDQCYGVIRNIQDAQYGGRRCYVELHQPDFAQFCASLKLAHHRITSLDDAERIVREGLAHEGPVLVEVDMLSVGSFAAAFAGPPVKKDTPAERQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LZ4</accession>
    <name>Q63LZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">feaB</name>
        <name evidence="6" type="ordered locus">BPSS0868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.39" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528142.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110877.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0868"/>
    <dbReference type="EnsemblBacteria" id="CAH38330">
        <property type="protein sequence ID" value="CAH38330"/>
        <property type="gene ID" value="BPSS0868"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0868"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7158"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DADMGHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008957">
        <property type="term" value="F:phenylacetaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="33"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="500" mass="52882" checksum="484204E10E512C94" modified="2004-10-25" version="1">MTQTDLVAVADTVRAFTEREFGVFIDGAMRAAHSPRRLDVFDPATGARLSRVPDADAHDVDAAVASAQRAFDARAWSGLRPAERERILLKLADVLEAHAEELAQLETLNQGKSILVSRGVEVGATIEYVRYMAGWATKITGQTLDVSIPFPPGARYTAYTRKEPVGVVAAIVPWNFPLMIAVWKLVPALAAGCTVVLKPSPETPLTALRLAELALEAGVPAGVFNVVTGARACGAALASHPAVRKISFTGSTATGKLVGAAAVQNMTRFSLELGGKNPIVMLEDVDVDAALGGVAAGAFFNQGQVCAAASRIYVHRSRFRRLAEGLAGVASAMRLGPGLDPAAQINPLVSAHHRDTVARHIDAARREGLTFLAGGTRADDLPGYFVRPAVIADAAHDSAIVRDEVFGPVVVVLPFDDPAEAVRLANASPYGLAASLWSNDLKAVMDLVPQIEAGTVWVNCHIPLDPSMPFGGYKQSGIGREFGQYAIEGFTETKSVCIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LZ9</accession>
    <name>Q63LZ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110872.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0862"/>
    <dbReference type="EnsemblBacteria" id="CAH38324">
        <property type="protein sequence ID" value="CAH38324"/>
        <property type="gene ID" value="BPSS0862"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0862"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4960"/>
    <dbReference type="eggNOG" id="COG3531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDPMCSW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="232" mass="24995" checksum="6DB840863383682F" modified="2004-10-25" version="1">MSERMTAMNPFRLQYFFDPLCGWCYASAPALAGLDAAHPGVLELMPSGLFADEGARELTPEWGEYAWRNDQRIEQMTGQRFTHAYREQVLRRGGVRFDSGPANRALSALRGVDARLERPLLEAIQLARYVDGLDTARPDVLARIAAGVAANAGVTTVDADALARRIEGDAALASETAGRIARTQRAMRQLGASGVPQLLLTVGERGYVLHGASLYGGAQAAVAAVERVLQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M45</accession>
    <name>Q63M45_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110826.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0815"/>
    <dbReference type="DNASU" id="3096166"/>
    <dbReference type="EnsemblBacteria" id="CAH38277">
        <property type="protein sequence ID" value="CAH38277"/>
        <property type="gene ID" value="BPSS0815"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0815"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4895"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYIETEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="22616" checksum="9D6B6CC08E62B90E" modified="2004-10-25" version="1">MASMNDIALTEEHRDALQEISNIGMGRAGAALAKLLGAFVTLSVPDIKLVSARELLDELQRCERRADMPRPVRQSFQSDICGEALVLFGSDGRRELKELMGYDDATDDIEDEALSDIASLLVGACVHSVFEQLDRRLTFLRPTFVPPGSLASALGDERLGRWDVALLLEVHFTLEHGGFVAKLVMLLPDAAIHKMKAALEQFLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M86</accession>
    <name>Q63M86_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939768.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110785.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0776"/>
    <dbReference type="EnsemblBacteria" id="CAH38236">
        <property type="protein sequence ID" value="CAH38236"/>
        <property type="gene ID" value="BPSS0776"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0776"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7023"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTDIEGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="33124" checksum="3BFEFE4BE64A6E34" modified="2004-10-25" version="1">MESSNRPARTHEASAATLLVDCRNALGEGATWCDAAHALYWVDIEGARLWRWRAAGAHGGERCDSWEMPERIACFALTGDPDVLLVGLASRLAFFDTRRRALTPIVDVEPDRPTRLNDGRCDRAGAFVFGTKDESGGASPRAIGGYYRLNADLSLQRLALPPAAIANGIAFSPDGSAMYFCDSPTREIQVCDYRPGGDVDRVRSFVRLADAHGEPDGSTVDASGGVWNAQWGGARVVRYDAQGVETDRIAVPTPQPSCVTLDAAGRLYVTSARVGLDDGALAGNPGAGGVFVAHTRHSGSATPRFALARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA8</accession>
    <name>Q63MA8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551511.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110763.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0752"/>
    <dbReference type="EnsemblBacteria" id="CAH38212">
        <property type="protein sequence ID" value="CAH38212"/>
        <property type="gene ID" value="BPSS0752"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0752"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6990"/>
    <dbReference type="eggNOG" id="ENOG502Z889">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANVQWDV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266987" evidence="2">
        <location>
            <begin position="23"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="548" mass="58347" checksum="FF0EE5F7A8451B69" modified="2004-10-25" version="1">MQRCLAHPARLLAATLLCVALAACGADDTNDSAAPPLARPNPTPDAPAPTPAAAPTYYQTKTPYRPQQDASRYEAPPAGYAPVYTEMLARHGSRGLSGFKYDGAIYDMLQKADAEGALTPLGRQLKADTFAMMKANALLGYGVAGISTPGYGNLTQAGIREHQQLAARLLQRLPALFDTVAGTTGGAARKIVVVHSGQDRAVDSSAYFSGALVAARPALAPAITSPSAIAGYPQGAPVAQAVGANRFLLYFHALKPSVDLVVSTDDPYYATYRDSLAYQAYGGSAAVTAKLDAIMRAPRTSQVARTVLAALVTPGFAAKLGTAGYTFSNTGTYTFASADAKFAHTLKGDGKTTIKSAADAANVLYNLLQVAPAMTAETGGVTMERYIAAPQAEYLAYLQDAEDFYEKGPGIAETNPITYRMAQALVDDFFAEIDAIARGDLTNAAKLRFTHAEVVIPFASILKLKDVFAPVPQAQTYTYANNPWRGETVAPMAANLQWDVYRNGARLIVKMLYNERETDFQPACDGARIAPGSRFYDYAGLRRCYGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MP4</accession>
    <name>Q63MP4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523196.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110627.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0606"/>
    <dbReference type="EnsemblBacteria" id="CAH38063">
        <property type="protein sequence ID" value="CAH38063"/>
        <property type="gene ID" value="BPSS0606"/>
    </dbReference>
    <dbReference type="GeneID" id="56530943"/>
    <dbReference type="KEGG" id="bps:BPSS0606"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6788"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGSWESW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="32985" checksum="5993F6250CF3C589" modified="2004-10-25" version="1">MSALPPLAAIRTFLVACRAGSFTAAADELCVTHSAVSRQIQTLESWLGTSLFEKDGQRMVPSVHARAFAQELGGALDALTDVVQRYGKGSARQALRVSVPTTFGMRWLIPRLAAFRDAHPDATIQVLTVTTQQQPSGGNCDVAIRRDDQVFNPESAIRFLSDHHTVVASPSLLSRTPLERPEDLVRHTILETETRPRHWDDWFAEAKLSASRFTRRQRFDHFHVTFQGIVDDLGVGIGPVVTLSRDLANGKIVAPFSDIRIAPHNYYAVTPIGIQKTALHREFEDWLVATAAAAETRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NE7</accession>
    <name>Q63NE7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase J</fullName>
            <ecNumber evidence="1">2.1.1.266</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2030)-N6)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m6A2030 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmJ</name>
        <name evidence="2" type="ordered locus">BPSS0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the adenine in position 2030 of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43736"/>
            <dbReference type="Rhea" id="RHEA-COMP:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:10669"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.266"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RlmJ family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.266" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538077.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110372.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0352"/>
    <dbReference type="EnsemblBacteria" id="CAH37800">
        <property type="protein sequence ID" value="CAH37800"/>
        <property type="gene ID" value="BPSS0352"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0352"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6475"/>
    <dbReference type="eggNOG" id="COG2961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYAIWYP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036307">
        <property type="term" value="F:23S rRNA (adenine(2030)-N(6))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00934">
        <property type="entry name" value="23SrRNA_methyltr_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007473">
        <property type="entry name" value="RlmJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37426">
        <property type="entry name" value="PTHR37426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04378">
        <property type="entry name" value="RsmJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="1">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="32037" checksum="86F3AE606D166524" modified="2004-10-25" version="1">MLSYRHGFHAGNHADVLKHTVVVQLLRYLNKKDKSYWYIDTHAGAGVYSLFDGYAAKTGEFGTGIEKIWDATDLPEALSDYVDEVRALNRDGELRYYPGSPYLAWRLMREQDRMRLFELHSTEIDVLRHNFRDAGRRAMIYAGDGFEGIKALLPPPPRRALVLVDPSYEDKRDYAKTTACVEESLKRFATGCYAIWYPQVSRPESQKFPDHLKQLQPNNWLHLSLTVSRPPSDGFGLFGSGMFILNPPYTLVDTMKEALPYLVEALGQDSGAKFAIEHRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NN4</accession>
    <name>Q63NN4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110285.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0266"/>
    <dbReference type="EnsemblBacteria" id="CAH37712">
        <property type="protein sequence ID" value="CAH37712"/>
        <property type="gene ID" value="BPSS0266"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0266"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4232"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QDNKAHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00363">
        <property type="entry name" value="TIGR00363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266622" description="Lipoprotein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="28495" checksum="75A06B8213D3C148" modified="2004-10-25" version="1">MTSIIRRVAGGAVWALAATLAHAGGPALKIGTMSGPDAQIWAEVTKVAARDGLAIKVIEFNDYVQPNAALDAGDLDANGFQHQPFLDSQIRQRGYRIVNVGLTYTSPMGFYSKRLKSLKDLPVGAKVGIQNDPSNGNRALLLLQKYGIVKLKPGAGVNGVNATPLDVAENPRKIRLVELDAAQLPRALPDLDAASINTDYAVKAGLSPVKDAIAIEDLKGPYANLIAVRAQDKDKPWVKKLVAAYESNDVRKFIETKFNGAIIPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NQ6</accession>
    <name>Q63NQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative exported heme receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS0244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939247.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110263.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0244"/>
    <dbReference type="EnsemblBacteria" id="CAH37690">
        <property type="protein sequence ID" value="CAH37690"/>
        <property type="gene ID" value="BPSS0244"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0244"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4210"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYARGFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011276">
        <property type="entry name" value="TonB_haem/Hb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010949">
        <property type="entry name" value="TonB_Hb/transfer/lactofer_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01785">
        <property type="entry name" value="TonB-hemin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01786">
        <property type="entry name" value="TonB-hemlactrns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266487" evidence="8">
        <location>
            <begin position="24"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="10">
        <location>
            <begin position="72"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="9">
        <location>
            <begin position="300"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="759" mass="81926" checksum="F068B0918A52262C" modified="2004-10-25" version="1">MARRPLRAALFGAFGLYAAAARAAGPASEPAAAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASRTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRGDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGNDRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINPPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAHKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDPLFTGKTVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQINNSFSNPIYGYTSIGNPNLKPETSDTLEAGLRGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASEPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYLGIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU0</accession>
    <name>Q63NU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187247.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110229.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0209"/>
    <dbReference type="EnsemblBacteria" id="CAH37654">
        <property type="protein sequence ID" value="CAH37654"/>
        <property type="gene ID" value="BPSS0209"/>
    </dbReference>
    <dbReference type="GeneID" id="56596962"/>
    <dbReference type="KEGG" id="bps:BPSS0209"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6279"/>
    <dbReference type="eggNOG" id="COG2828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VPATYMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012709">
        <property type="entry name" value="PrpF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="PTHR43709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02334">
        <property type="entry name" value="prpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="40914" checksum="4B3A8241968EAE2E" modified="2004-10-25" version="1">MAHVPQIKIPATYLRGGTSKGVFFRLQDLPEAARTPGAARDALLSRVIGSPDPYGKQIDGMGGASSSTSKTVIVSKSARPDHDVDYLFGQVSIDKPFVDWSGNCGNLSAAVGPFAIAGGLIDPARVPENGVATVRIWQANIGKTIVAHVPITNGAVQETGDFELDGVTFPAAEVQLEFMDPAADEDGAGGAMFPTGNLVDDLDVPGVGTLKATMINAGIPTIFVDAAAIGYTGTELQDAINSDAKALAMFETIRAHGALRMGLIASLDEIATRQHTPKVAFVAKPADYVASSGKRVAAADVDLLVRALSMGKLHHAMMGTAAVAIGTAAAIPGTLVNLAAGGGARHAVRFGHPSGTLRVGAEAKQDGGEWVVTKAIMSRSARVLMEGWVRVPGDAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NV1</accession>
    <name>PXPA2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A 2</fullName>
            <shortName evidence="1">5-OPase subunit A 2</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA2</name>
        <name type="ordered locus">BPSS0198</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529746.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110218.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63NV1"/>
    <dbReference type="SMR" id="Q63NV1"/>
    <dbReference type="STRING" id="272560.BPSS0198"/>
    <dbReference type="EnsemblBacteria" id="CAH37643">
        <property type="protein sequence ID" value="CAH37643"/>
        <property type="gene ID" value="BPSS0198"/>
    </dbReference>
    <dbReference type="GeneID" id="56531349"/>
    <dbReference type="KEGG" id="bps:BPSS0198"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6266"/>
    <dbReference type="eggNOG" id="COG1540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHGELYF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000184999" description="5-oxoprolinase subunit A 2">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <sequence length="266" mass="28868" checksum="51DDB4CFC5EC3709" modified="2004-10-25" version="1">MRKHSVDLNSDMGEGFGPWKIGDGVDEEIMPLISSANIATGFHAGDPNIIARTVQLAKNAGVGVGAHPGFRDLVGFGRRDIGETPQALVNDIVYQLGALREFARFHGVSVQHVKPHGALYMRAARDEALSRLLVETLQQLDPALRLYCMEASVTYRIARELGQPVVREFYADRDYGRNGSIVFTRRAGRLDPRQVADKVLRACVDGRVATVDGEDIDIDFDSICLHSDTPGALALARATRDALTAHGIRIAAPATAEANGIRIDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P65</accession>
    <name>Q63P65_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS0080a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523722.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110104.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0080a"/>
    <dbReference type="EnsemblBacteria" id="CAH37526">
        <property type="protein sequence ID" value="CAH37526"/>
        <property type="gene ID" value="BPSS0080a"/>
    </dbReference>
    <dbReference type="GeneID" id="56531473"/>
    <dbReference type="KEGG" id="bps:BPSS0080a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6099"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRGIIRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9084" checksum="0E03943DA846D5A6" modified="2004-10-25" version="1">MRGVIRIGDSTSHGGRVETGREGSTVMGRAVACVGDRCTCPMNGHEHCVIVEGDEDVRIEGRAVAFDGHRTSCGATLVSSIPTSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PE3</accession>
    <name>Q63PE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539583.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110026.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0002"/>
    <dbReference type="EnsemblBacteria" id="CAH37445">
        <property type="protein sequence ID" value="CAH37445"/>
        <property type="gene ID" value="BPSS0002"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0002"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5996"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGAFLTW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="135"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="347" mass="38334" checksum="98120C7A6AEDA32D" modified="2004-10-25" version="1">MSLPILTSPPSPPDIPSDLFDRDTSDWLNHPDTAFDAWLAAQEFRRSSADVYRAQWGAFLGWLAKRQKNLATVDTETIALFVGELPIKKTQRVRYLRLIERVLDHVRKNEFGSTNPARFIAQDGEATWRAARDNEPTSFLAPAERAALLAYLFSPLPAAGAALWKERRDRALIAVFLGGGLKTGEARALTISCVKLGSTMLTIPAAQPEFTRETHLASFAIALFDAWLAERQRCGIPGELVFPASQSGRPMHKATMLRAVDAIVDAADIAQSRTARASPQTLRNTFAAELFENGVEPEKVGQWLGFAQPISSNRLHRAWKNWRESLASALPNAESLTDEISTEPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PF4</accession>
    <name>Q63PF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195801.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110015.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3422"/>
    <dbReference type="EnsemblBacteria" id="CAH37434">
        <property type="protein sequence ID" value="CAH37434"/>
        <property type="gene ID" value="BPSL3422"/>
    </dbReference>
    <dbReference type="GeneID" id="56593922"/>
    <dbReference type="KEGG" id="bps:BPSL3422"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1763"/>
    <dbReference type="eggNOG" id="COG1437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HLFLHGQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="176" mass="19717" checksum="FCF322FF72D98B79" modified="2004-10-25" version="1">MARNIEIKARAREFEQLRERAAELATDAPLFYRQQDFFYDVPRGRLKLRRFEDGTPAELIFYQRDDQDGPKASYYTRSPVTNADAMHALLATALTTRGIVTKERHVYLAGRTRIHLDRVDGLGDFVELEVVLGPDDDEDGGHAEAHAVFAKLGVPSDDLVAVAYVDLLNAQAEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PV4</accession>
    <name>Q63PV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109864.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3268"/>
    <dbReference type="EnsemblBacteria" id="CAH37281">
        <property type="protein sequence ID" value="CAH37281"/>
        <property type="gene ID" value="BPSL3268"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3268"/>
    <dbReference type="eggNOG" id="ENOG5034BDC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="33258" checksum="475BB561C2D2939A" modified="2004-10-25" version="1">MDRRCQIASGSVRPLPALRHVWPNRRQYPVDFDRIGVQLWLWPLQHSKRPTTMSERTPGEISSGFADLKEGAALLVQAKPNLAMAAVTVAIGVLAILTRFPTKDGSATLAGALFGAAAIFIGAWVTESTKAAAERAALLRRQQAARAFFTPELARIAAQQVHILDRLIVNFGEASLGRVYNEDPLISLRPQSPLLYPGAAQFGDLPELDAVLLVDFYDASHGVSQTVDSWIENKTKIDFNAYNVLMQMVMHSLKVGVAAIDSFCPDRQYSPLVPVAGKLVDRIEKSIDHARNALAAHLKRSGVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q03</accession>
    <name>RPOB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">BPSL3221</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198365.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109815.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q03"/>
    <dbReference type="SMR" id="Q63Q03"/>
    <dbReference type="STRING" id="272560.BPSL3221"/>
    <dbReference type="EnsemblBacteria" id="CAH37232">
        <property type="protein sequence ID" value="CAH37232"/>
        <property type="gene ID" value="BPSL3221"/>
    </dbReference>
    <dbReference type="GeneID" id="56594534"/>
    <dbReference type="KEGG" id="bps:BPSL3221"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2017"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000224038" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <sequence length="1368" mass="153151" checksum="7EDFD6048DF7CD1A" modified="2004-10-25" version="1">MQYSFTEKKRIRKSFAKRSIVHQVPFLLATQLESFSTFLQADVPTAQRKSEGLQAAFTSVFPIVSHNGFARLEFVSYALSSPAFNIKECQQRGLTYCSALRAKVRLVLLDKESPSKPVVKEVKEQEVYMGEIPLMTPTGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDVLYFRVDRRRKMPVTILLKAIGLTPEQILANFFVFDNFTLMDEGAQMEFVPERLRGEVARFDITDREGKVIVQKDKRINAKHIRDLEAAKTKYISVPEDYLLGRVLAKNVVDGDTGEVIANANDEITEGVLEKLREAKIKEIQTLYTNDLDQGPYISSTLRVDETVDKTAARIAIYRMMRPGEPPTEEAVEALFNRLFYSEDAYDLSKVGRMKFNRRVGRDEITGPMTLQDDDILATIKILVELRNGKGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAESENLMPHDLINSKPISSAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYAHLNEYGFLETPYRKVVDSKVTDQIDYLSAIEEGRYMIAQANAAIGDDGALVDELVSSREAGETMMVTPDRIQYMDVAPSQIVSVAASLIPFLEHDDANRALMGSNMQRQAVPCLRPEKPVVGTGIERTVAVDSGTTVQALRGGVVDYVDAGRIVIRVNDDEAVAGEVGVDIYNLIKYTRSNQNTNINQRPIVKMGDKVSRGDVLADGASTDLGELALGQNMLIAFMPWNGYNFEDSILISERVVADDRYTSIHIEELNVVARDTKLGPEEITRDISNLAEVQLGRLDESGIVYIGAEVEAGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMSGTVIDVQVFTREGIQRDKRAQQIIDDELKRYRLDLNDQLRIVEGDAFQRLARMLVGKVANGGPKKLAKGTKIDQAYLEDLDHYHWFDIRLADDEAAVQLEAIKNSIEEKRHQFDLAFEEKRKKLTQGDELPPGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPVEDMPYMADGRPADVVLNPLGVPSRMNVGQVLEVHLGWAAKGLGWRIGEMLARQTKIEELRVFLTKIYNESGRAEDLESFSDDEILELAKNLREGVPFATPVFDGATEEEMSKMLDLAFPDDIAEQLDMNPSKNQVRLYDGRTGEPFERRVTVGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVTGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDLDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QL6</accession>
    <name>Q63QL6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL3007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194395.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109602.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3007"/>
    <dbReference type="EnsemblBacteria" id="CAH37018">
        <property type="protein sequence ID" value="CAH37018"/>
        <property type="gene ID" value="BPSL3007"/>
    </dbReference>
    <dbReference type="GeneID" id="56594265"/>
    <dbReference type="KEGG" id="bps:BPSL3007"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3436"/>
    <dbReference type="eggNOG" id="COG4536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="2"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH37018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="431" mass="47989" checksum="1008A76BF0CC82D9" modified="2004-10-25" version="1">MDQIPLWAQIGAVFLLLLCSSFFSISETAMMALNRHRLKHLASHGALGAKTTQRLLARTDQLLSVILIGNNLFNTIIPVLTTSIALRTFGHDNFVLSIATGIVAFLIIVFAEITPKIVGATFPERIALPASVVIAPLMRVMMPVVWFVNTLSGAILAALRINTKAGRDQRLSTEELRSLVLESGSFMPTKHRSILLNLFDLENITVDDVMIPRRQIESLNILAPLDDVLHQLETCYHNRLVVYEGDIDRVLGVLHVRKTLAAFHNQDFDRGTLRELLAQPYYVPSGTPVFQQLQYFQESRHRTALVVNEYGELEGLVTPEDIIEELIGEFTTTMPRSENSKSGWDANGECIVAASMPLRELNRWLHLGLPTNGPKTLNGLILEELEEIPEDDVCLKIGDVMIEVMRTEDQGVRTVKLFKPRAPRGGRAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QP3</accession>
    <name>Q63QP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative thioredoxin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109575.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2981"/>
    <dbReference type="EnsemblBacteria" id="CAH36991">
        <property type="protein sequence ID" value="CAH36991"/>
        <property type="gene ID" value="BPSL2981"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2981"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3407"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMLRFKK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17226" checksum="BC51918838AE43BB" modified="2004-10-25" version="1">MRGNPASGPQAGTPAGAPAAGNPVDTLWAASYPDVDGKPQRLAAFKGQKLVVNFWASWCGPCVEEMPELVKLSREYEKKGVRFVGIGVDSDQNVKNFLKKVPVDYPIVVSGYAGADLARHFGNTAGALPFTVVIDETGKIRETKLGQIRPDELKRTLDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QW8</accession>
    <name>Q63QW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutathione S-transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527730.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109500.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2906"/>
    <dbReference type="EnsemblBacteria" id="CAH36916">
        <property type="protein sequence ID" value="CAH36916"/>
        <property type="gene ID" value="BPSL2906"/>
    </dbReference>
    <dbReference type="GeneID" id="56528291"/>
    <dbReference type="KEGG" id="bps:BPSL2906"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2383"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SGSIMQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="90"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="232" mass="26217" checksum="93CFCA20AE12CE20" modified="2004-10-25" version="1">MIDLYYWTTPNGHKITMFLEEAGLPYRIVPVNIGRGEQFEPAFLRIAPNNRIPALVDHAPADGGAPLSIFESGAILLYLADKLGRFIPADLRGRNEALQWLFWQMGGLGPMAGQNHHFVQYAPEPLPYAIERYVKETSRLYGVLNKHLSDGRDYIAGEYSIADMASYPWIVPHERQRQRLEDFPFLAAWFARVAERPGTVRAYARAKEINTAPTVDQQSRGVLFGQDASTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ6</accession>
    <name>Q63QZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative paraquat-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522113.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109472.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2878"/>
    <dbReference type="EnsemblBacteria" id="CAH36888">
        <property type="protein sequence ID" value="CAH36888"/>
        <property type="gene ID" value="BPSL2878"/>
    </dbReference>
    <dbReference type="GeneID" id="56528321"/>
    <dbReference type="KEGG" id="bps:BPSL2878"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2417"/>
    <dbReference type="eggNOG" id="COG2995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRFIEWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007498">
        <property type="entry name" value="PqiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="220" mass="24015" checksum="5395C6562233B391" modified="2004-10-25" version="1">MTGIVTAARAGMASCHACGHVQKLARPAQQALGSHDRPERCARCGAALHLRTPDSIARTLALLIAAAILYIPANLLPIMRTTSIVGSQEDTIMSGVVYFWTSGEWPLAVVVFVASILVPMMKLGVLAILVYTAQRRSAWRPMQRTRLYRIVERIGRWSMLDIFVVTLTVALVHFRSLAVITAGPGALAFGSVVILTMLASMQFDPRLIWDNVEHSGNAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R61</accession>
    <name>Q63R61_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homoheptamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109407.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2812"/>
    <dbReference type="EnsemblBacteria" id="CAH36822">
        <property type="protein sequence ID" value="CAH36822"/>
        <property type="gene ID" value="BPSL2812"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2812"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3208"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIGFTVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="30902" checksum="356A9AF43D74DC13" modified="2004-10-25" version="1">MASRPPPFNSFGDLIVDLASVQTFIVTRGLDFGLQVIASIALWIFGRWAIRIVTNLMGKLIRRSGKVDSTLSHYLESVVSVLLTVLLILAILQVFGVQTTSFAALLAGLGLAVGTAWGGLLAHFAAGVFMQVLRPFKVGDVISAGGVTGTVKELGLFGTTIVTADNVVTLVGNNKIFSDNIANYSATPTRRVDLTAKIANGVDAADAIKRLKAALELIPNVVKHPAPDVGVLSFTPEGPLLFVRPSTQPANYWQVYCDTNRAILDTFREAGYPTPETPVAHRTTADVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF4</accession>
    <name>Q63RF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938508.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109314.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2718"/>
    <dbReference type="EnsemblBacteria" id="CAH36726">
        <property type="protein sequence ID" value="CAH36726"/>
        <property type="gene ID" value="BPSL2718"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2718"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3100"/>
    <dbReference type="eggNOG" id="COG2358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVNRMKM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="505" mass="54662" checksum="EEAC84264A95E825" modified="2004-10-25" version="1">MLRRGAAAAAPNSGTIAANRSPAFSQMKPEPTRRRRPHRIVARFVAVSWRDLAMSIGPTVVLSIAAVWLAIALIQPAPPTSLTISAGPPGSTNWRSAQRYKQILAKNGVTLRVLESEGSAENLARLSDPAQKVDVGFVQSGIEQKGKHEALVSLGSVGYVPLAILYRGPVIERLSQFKGKRLALGAEGAGAHELGLALLKMNGIVPGGPTPLLPLSGEDAARALTEGRIDAAFLSGDSTQIPVMAKLFRTPGVHFYSFTQAEAYTRRVAYLTDITLPMGVYDPGTNLPPSDIHTLSPTVELIARDTLHPALSDLLIEAARDVHGRATILQRAGEFPSPVTHSSFLLSDDAARYYKSGKTFLYRKLPFWVASLVDRLLFIVVPLVVVLIPGLRLVPTLYGWRVRSRIYRWYGALIALERSALGEHTAQERVVLLDKLDDVEESVNRMKMPLAYAGQFYVLREHIGFVRGRLLARDYETPQPAAATPPAAPTPPGAPPAGSRQPGDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RP1</accession>
    <name>UBID_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-octaprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
            <ecNumber evidence="1">4.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polyprenyl p-hydroxybenzoate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiD</name>
        <name type="ordered locus">BPSL2631</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:41680"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9516"/>
            <dbReference type="ChEBI" id="CHEBI:1269"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="4.1.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN (prenyl-FMN) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.98" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536419.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109227.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RP1"/>
    <dbReference type="SMR" id="Q63RP1"/>
    <dbReference type="STRING" id="272560.BPSL2631"/>
    <dbReference type="EnsemblBacteria" id="CAH36639">
        <property type="protein sequence ID" value="CAH36639"/>
        <property type="gene ID" value="BPSL2631"/>
    </dbReference>
    <dbReference type="GeneID" id="56528568"/>
    <dbReference type="KEGG" id="bps:BPSL2631"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2720"/>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008694">
        <property type="term" value="F:3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01636">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023677">
        <property type="entry name" value="UbiD_bacteria"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000267654" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01636"/>
        </source>
    </evidence>
    <sequence length="519" mass="57359" checksum="B915979D7691FC35" modified="2004-10-25" version="1">MKYKDLRDFIHGLEQRGELRRVTQPVSPVLEMTELCDRVLRAGGPALLFDAPAGHRFPVLGNLFGTPRRVALGMGVDADDEAALASLRDIGRLLSALKEPDPPKRLKDAGKLLSLAKAVWDMSPKTVSAPPCQEIVWEGDDVDLHKLPIQTCWPGDAGPLLTWGLTVTRGPNKTRQNLGIYRQQLIGRNKLIMRWLAHRGGALDFREFALKHPGQPYPVAVVLGADPATMLGAVTPVPDSLSEYQFAGLLRGARTELAKCVTPGVDALQVPARAEIVLEGFIHPQQGAPAPAPEGAPPRPAAGAAAGYEHALEGPYGDHTGYYNEQEWFPVFTVERITMRRDAIYHSTYTGKPPDEPAVLGVALNEVFVPLLQKQFAEITDFYLPPEGCSYRMAIVQMKKSYAGHAKRVMFGVWSFLRQFMYTKFIVVVDEDVNVRDWKEVIWAITTRVDPARDTVLVENTPIDYLDFASPVAGLGSKMGLDATNKWPGETQREWGRPIEMDAAVKARVDRLWTEIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR0</accession>
    <name>Q63RR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">malE</name>
        <name evidence="2" type="ordered locus">BPSL2611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185848.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109207.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2611"/>
    <dbReference type="EnsemblBacteria" id="CAH36619">
        <property type="protein sequence ID" value="CAH36619"/>
        <property type="gene ID" value="BPSL2611"/>
    </dbReference>
    <dbReference type="GeneID" id="56594865"/>
    <dbReference type="KEGG" id="bps:BPSL2611"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2743"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWLWINP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267088" evidence="1">
        <location>
            <begin position="25"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="415" mass="44302" checksum="77684232C8E1E183" modified="2004-10-25" version="1">MKIRAIMGALGAAGLLFGAAAAQAAENVTVLHWWTSGGESKAVGVLKDDLQKQGYVWKDFAVAGGAGAAAMTALKTKVISGDAPSAAQIKGPLIQEWADQGVLVNIDAAAGDWKQNLPPEIDKIIKYKGNTVAAPFSVHRVNWLYINKAALDKIGAKPPATWPEFFQVADKLKAAGIQPVAMGGQPWQDLTLWEDVVLSQGADFYRKALVELDQKTLTSDKMLEVFNTVRKIQGYFDSGRNGRDWNLATAMVINGRAGMQFMGDWAKGEFEAAGKKPGKDYICAAVPGTANAYTFNVDSFVFFQQKGQKAATPGQIALAKTIMTPAFQEQFSLLKGSIPVRLGVKMDKFDDCAKKSYADEQTAIKSGGYVPSLAHGMAQGDATAGAISDVVTKFMNSQQDAKSALAALARAAKVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ8</accession>
    <name>UBIG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-polyprenyl-6-hydroxyphenol methylase</fullName>
            <ecNumber evidence="1">2.1.1.222</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.64</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiG</name>
        <name type="ordered locus">BPSL2523</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:31411"/>
            <dbReference type="Rhea" id="RHEA-COMP:9550"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:62729"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="EC" id="2.1.1.222"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.222" evidence="1"/>
    <dbReference type="EC" id="2.1.1.64" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532296.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109119.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RZ8"/>
    <dbReference type="SMR" id="Q63RZ8"/>
    <dbReference type="STRING" id="272560.BPSL2523"/>
    <dbReference type="EnsemblBacteria" id="CAH36530">
        <property type="protein sequence ID" value="CAH36530"/>
        <property type="gene ID" value="BPSL2523"/>
    </dbReference>
    <dbReference type="GeneID" id="56596436"/>
    <dbReference type="KEGG" id="bps:BPSL2523"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2857"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGTHDWE"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102208">
        <property type="term" value="F:2-polyprenyl-6-hydroxyphenol methylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008689">
        <property type="term" value="F:3-demethylubiquinone-9 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000193375" description="Ubiquinone biosynthesis O-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00472"/>
        </source>
    </evidence>
    <sequence length="232" mass="25206" checksum="7A9B33BE4BC739CC" modified="2004-10-25" version="1">MTNADPHELQKFSDLAHKWWDPNAEFKPLHDLNPVRLSWIDAHAHLPGKRVVDIGCGGGILSESMASLGAQVKGIDLATEALGVADLHSLESGVSVDYEAIAAEALAAREPGAYDVVTCMEMLEHVPSPANIVAACATLVKPGGWVFFSTLNRNLKSYLLAVIGAEYIAQMLPKGTHDYARFIRPSELARFVREAGLQMVEIKGIAYHPLAKRFALSNDTDVNYLVACRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE1</accession>
    <name>Q63SE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAH36384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2382"/>
    <dbReference type="EnsemblBacteria" id="CAH36384">
        <property type="protein sequence ID" value="CAH36384"/>
        <property type="gene ID" value="BPSL2382"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2382"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2713"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYDCWRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="244"/>
        </location>
    </feature>
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            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="46146" checksum="DCF0BAC1DCA1F621" modified="2004-10-25" version="1">MRAAARALRRMAANRGATARRASLSLCVTDSMNDSSHPIRVDEPMPHRKVIRSWITPFGERVIARSIVLLAVDYLLLFAAFAGALLAASGIVKIVCGMAAGFITGRLFIIGHDACHQSLTPNHRLNRWLGRIAFLPSLTPYSLWEVGHNVVHHGYTNLKGFDFVWAPLTPGEYAALSPARRLLDRIYRSGWAPGLYYLVEIWWLRMYFPAKAYLGASRPIFRRDCLLVTGFAALWIGAVVWIAAATRQSMPLLLVTGVAVPFLFWCSMIGFVVYVHHTDPRISWHANRAEWSRAAPFVSTTLHLTFPFGIGGLLHHIMEHTAHHVDMSIPLYGLKDAQAKLEAMLPGRIVVQRFSWRWYFDTARRCKLYDTDRKRWTDYRGRATSDAHLRADAPMAEQRPIDAPHGPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE4</accession>
    <name>Q63SE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquinol oxidase polypeptide I</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cyoB</name>
        <name evidence="8" type="ordered locus">BPSL2379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2379"/>
    <dbReference type="EnsemblBacteria" id="CAH36381">
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        <property type="gene ID" value="BPSL2379"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|272560.51.peg.3026"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014207">
        <property type="entry name" value="Cyt_c_ubiqinol_oxidase_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02843">
        <property type="entry name" value="CyoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="101"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="39"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="668" mass="74245" checksum="D66E1DF6E09A7CEC" modified="2004-10-25" version="1">MFGKLTLSAIPFDQPIVMGAAALMALVALSVVGALTYTKRWKWLWCEWLTSVDHKKIGVMYIVVAVLMLLRGFADAVMMRLQLALAYNGPGYLPPHHYDQIFTAHGVIMIFFMAMALLVGLFNLIVPLQIGARDVAFPFLNSLSFWMTAVAALLMNVSLVVGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLITAINFFVTIIRMRAPGMTLMKMPVFTWTALCSNVLIMATFPILTVALALLALDRYLGMHFFTNDAGGNAMVYLNLIWAWGHPEVYILVLPAFGIYSEVIATFSKKPLFGYKTMVYASCVIMVLAFLVWLHHFFTMGSGANVNAFFGIMTMVIAIPTGVKIFNWLFTMYRGRIEFTAPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFHNAIIGGVVFGYLAGFHYWFPKAFGFKLDEKLGKRAFWCWFIGFYVSFVPLYVLGFMGMTRRLNHYDNPAWHPWLIVAACGVALIALGVLHQVAQVWVAVRNRNAPGYRDTTGDPWDGRTLEWATASPPPVYNFAVIPTVHALDELAYRKEHGIGVGKNAVYQDIHMPSNTSAGLFVGMFSLVLGFALVWHIWWLAITAFVGIVAMVVLYSAGENDGYYIAADTVREIEERRAGARAPARPAEVELEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SG5</accession>
    <name>Q63SG5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative pyruvate radical-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196980.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108951.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2358"/>
    <dbReference type="EnsemblBacteria" id="CAH36360">
        <property type="protein sequence ID" value="CAH36360"/>
        <property type="gene ID" value="BPSL2358"/>
    </dbReference>
    <dbReference type="GeneID" id="56596265"/>
    <dbReference type="KEGG" id="bps:BPSL2358"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3053"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDIKAPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02495">
        <property type="entry name" value="NrdG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="239" mass="25797" checksum="FE6FA5872279F049" modified="2004-10-25" version="1">MNLALPRRRPLKVGGLVPFTATDYPGQFAAVVFVQGCPWRCGYCHNPHLQPRSQPAEIEWDALLAFLARRVGLIDAVVFSGGEPSIDPALAASIDDVRRLGFKVGLHSAGTHPRRLAHLLPSLDWIGLDVKAPFDDYAHTTRVRASGGHARQSLEAVLASGIAYECRTTAHPDLLPEPALLRVAHELADLGVEHYVLQVFRAQGCGSGALNAASLAGYPSDAVLGRLDRLFANFAIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SM4</accession>
    <name>Q63SM4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205153.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108892.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36299">
        <property type="protein sequence ID" value="CAH36299"/>
        <property type="gene ID" value="BPSL2296"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2296"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3133"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFVVICQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="2">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="3">
        <location>
            <begin position="325"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="487" mass="56102" checksum="0DEBB573251FC303" modified="2004-10-25" version="1">MLKTPMPTQHELEMVTLEELVPKDHLLRQIDAAVDFEFIRAKVAHLYCADNGRPALDPVVMFKLLFIGYLFGVRSERQLMREVQVNVAYRWFARFRLTDKVPDASTFSQNRRRRFTDTTVYQEIFDEIVRQAIKRGLVDGRVLYTDSTHLKANANKGKFDVVKLEQTPAAYTEALNAAVDADRAMHGRKPLDRDDDEPPSSKDTKLSRTDPDSGYMVRDDKPKGFFYLDHRTVDAKHAIITDTHVTPASVHDSQPYLDRLDRQRERFEFKVEAVGLDAGYFTPAVCQGLEERGIAGVMGYRTPNHKPGMFYKRQFKYDAYRNEYVCPQGQALPYSTTNRLGYREYKSNAQICGRCPVRSQCTNSAIAVKVVTRHVWERAKERVDARRLTEWGQRIYARRKQTVERSFADAKQLHGHRYARMRGLRKVAEQCLLAAAAQNIKKIAMLLARKRKKGPAGPDWRFVRMLLRLVSGLRCSFDYPLAANPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ST9</accession>
    <name>Q63ST9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108827.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2232"/>
    <dbReference type="EnsemblBacteria" id="CAH36234">
        <property type="protein sequence ID" value="CAH36234"/>
        <property type="gene ID" value="BPSL2232"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2232"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2533"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANAPYYY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="555"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="630" mass="67877" checksum="7A88FE4462F7D548" modified="2004-10-25" version="1">MTPPLRSFLRRRPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARFADVAARRGDALAVTCGDERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPELAETAARLGVSARVIDDARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRMTLLPYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAAFARPAALRWVVLGGEAATGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASIARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALGYWGRAELSAERFRQTARPDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLPRLDEATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRALPAPPRAEVAAGERKAPRTPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRVKRDLELDARLGDLFRHPTVESLAEHLLACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SZ2</accession>
    <name>Q63SZ2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dadX</name>
        <name evidence="7" type="ordered locus">BPSL2179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191260.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108774.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63SZ2"/>
    <dbReference type="STRING" id="272560.BPSL2179"/>
    <dbReference type="EnsemblBacteria" id="CAH36181">
        <property type="protein sequence ID" value="CAH36181"/>
        <property type="gene ID" value="BPSL2179"/>
    </dbReference>
    <dbReference type="GeneID" id="56595962"/>
    <dbReference type="KEGG" id="bps:BPSL2179"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3272"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HMTHFSD"/>
    <dbReference type="BRENDA" id="5.1.1.1">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="232"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="38334" checksum="B29D6F1F142DD41E" modified="2004-10-25" version="1">MPRPISATIHTAALANNLSVVRRHAAQSKVWAIVKANAYGHGLARVFPGLRGTDGFGLLDLDEAVKLRELGWAGPILLLEGFFRSTDIDVIDRYSLTTAVHNDEQMRMLETARLSKPVNVQLKMNSGMNRLGYTPEKYRAAWERARACPGIGQITLMTHFSDADGERGVAEQMATFERGAQGIAGARSFANSAAVLWHPSAHFDWVRPGIMLYGASPSGRAADIADRGLKPTMTLASELIAVQTLAKGQAVGYGSMFVAEDTMRIGVVACGYADGYPRIAPEGTPVVVDGVRTRIVGRVSMDMLTVDLTPVPQAGVGARVELWGETLPIDDVAARCMTVGYELMCAVAPRVPVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TC6</accession>
    <name>Q63TC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL2042A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108640.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2042A"/>
    <dbReference type="EnsemblBacteria" id="CAH36042">
        <property type="protein sequence ID" value="CAH36042"/>
        <property type="gene ID" value="BPSL2042A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2042A"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2307"/>
    <dbReference type="OMA" id="DECIAYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9625" checksum="7DFD73E470962A80" modified="2004-10-25" version="1">MCRPMRSMVHLKRDECIAYRQSLDGADVLTPPKALDAGRVDYFAVVMPGCTEPEQVDGASFRVLDRAAGRVRIALPSQDDGQCAWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TL9</accession>
    <name>Q63TL9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108547.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1948"/>
    <dbReference type="ESTHER" id="burma-q62kh9">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35947">
        <property type="protein sequence ID" value="CAH35947"/>
        <property type="gene ID" value="BPSL1948"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1948"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4092"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRMAYHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="301" mass="32641" checksum="AAAD657378133F35" modified="2004-10-25" version="1">MSSNPATSVSPRERRVQCANPLGLHHIAYTEWGDPANPRVLVCVHGLTRSGRDFDRLAAALSDVYRVVCPDVAGRGRSDWLADPKRYAVPQYVSDIVTLIARLDVERVDWFGTSMGGLIGLALGGLPGTPIGRMLVNDIGPHIEPAALERIGEYVGLDKRFATEQEGVDYLTSLSLSFGPLTPDEWRALNRPLLVRDADGSWRARYDPRIAEPFKTATPEANAQGEAWLWHALGAFAGPLLVVRGVQSDLLSRETLEAMKARGQAVTSVEIAEAGHAPAFVSAEQIAIARQFFVGDAPHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TQ2</accession>
    <name>Q63TQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative multidrug resistance protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">emrA</name>
        <name evidence="7" type="ordered locus">BPSL1914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205096.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108514.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1914"/>
    <dbReference type="EnsemblBacteria" id="CAH35914">
        <property type="protein sequence ID" value="CAH35914"/>
        <property type="gene ID" value="BPSL1914"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1914"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4058"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VQITPQI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005694">
        <property type="entry name" value="Efflux_pump_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00998">
        <property type="entry name" value="8a0101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="6">
        <location>
            <begin position="59"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="5">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="411" mass="43741" checksum="1A7926CFDB8C922D" modified="2004-10-25" version="1">MSDPQQNAAPAQPQNNGKRKRMMTLLVVVIAIAAIAYGLYYLLVARFHETTDDAYVNGNVVQITPQVTGTVIAVKADDTQTVKSGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLYVNDDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEISHARDAVKAAQASLDAAGQQLASNRALTANTTVADHPNVLAAAAKVRNAYLNNARNTLPAPVTGYVAKRSVQVGQRVSPGTPLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVKYHGKVIGFSAGTGAAFSLLPAQNATGNWIKVVQRLPVRVELDPKELKEHPLRIGLSMQVDVDIKDESGNQLGNVQNTVYETDVFAKYGDEADAEIARIIAQNAGGGAAGGASAPTPAAKLVGRASNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TS7</accession>
    <name>Q63TS7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205093.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108489.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1889"/>
    <dbReference type="EnsemblBacteria" id="CAH35889">
        <property type="protein sequence ID" value="CAH35889"/>
        <property type="gene ID" value="BPSL1889"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1889"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4032"/>
    <dbReference type="eggNOG" id="ENOG50339NA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTGQANA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022053">
        <property type="entry name" value="DUF3613"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12266">
        <property type="entry name" value="DUF3613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266577" evidence="2">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="131" mass="12801" checksum="EF3877A6682A0C5B" modified="2004-10-25" version="1">MTTHDLTQTAAPRAGRGRALCAAALALALACAVGAARAQSPQRDAPSASEIGHATQTWFALQASNREAAPAQPMIGEAASLAYARYIESFRTKIPAFYGSAAGMSGMSGGGGGGGGGGGAGYSLAPASGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TW0</accession>
    <name>Q63TW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aliphatic sulfonates transport permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssuC</name>
        <name evidence="6" type="ordered locus">BPSL1857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191980.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108456.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1857"/>
    <dbReference type="EnsemblBacteria" id="CAH35856">
        <property type="protein sequence ID" value="CAH35856"/>
        <property type="gene ID" value="BPSL1857"/>
    </dbReference>
    <dbReference type="GeneID" id="56595648"/>
    <dbReference type="KEGG" id="bps:BPSL1857"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3989"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="273" mass="29279" checksum="43CC7DCC16E67AB0" modified="2004-10-25" version="1">MTTTHSRAHFAARRAAGRAARAVAPWLVPLVLVLAWEFAARAGALSSRVLPEPLAVVRAAWALVESGDMWANVKVSTWRALVGFAIGGGVGLALGLATGLSKAAEVALDSTIQMIRNIPALAMIPLVILWFGIDEKAKLFLVALGVFFPVYINTYHGIRSVDAGLVEMARSYGVRGFALYRDVILPGALPSILVGVRFALGLMWVMLIVAETISAQSGIGYMTMNAREFLQTDVVVVGILLYAVLGKLADVLAKWLERATLRWLPAHQPGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX2</accession>
    <name>Q63TX2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL1845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit encodes the transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (NodI) and two transmembrane proteins (NodJ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC-2 integral membrane protein family. Lipooligosaccharide exporter (TC 3.A.1.102) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192376.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108444.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1845"/>
    <dbReference type="EnsemblBacteria" id="CAH35844">
        <property type="protein sequence ID" value="CAH35844"/>
        <property type="gene ID" value="BPSL1845"/>
    </dbReference>
    <dbReference type="GeneID" id="56595630"/>
    <dbReference type="KEGG" id="bps:BPSL1845"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3974"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSAFSRM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015772">
        <property type="term" value="P:oligosaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005981">
        <property type="entry name" value="ABC_transptNodJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01291">
        <property type="entry name" value="nodJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0536">Nodulation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="12">
        <location>
            <begin position="32"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="30164" checksum="EDCC0E5C03FC0201" modified="2004-10-25" version="1">MDTRHYTPSPTLAARRRESAFALALPANATNWIAVWRRNYLVWQKLAIASMFGNLADPMIYLFGLGLGLGLMVGHVEGVSYIAFLAAGTVGSSVMISASFESMYSGFSRMHVQRTWEAIMHTPLSLGDIVLGEIVWAASKAMLSGAAIMLVAGVLGYAKFPSMLVALPVIALAGIAFASLAMIVTALAPSYDFFMFYQTLALTPMLLLSGVFFPLAQLPEFAQHIAHALPLSNAVDLIRPAMLDRPATDVARHVAILAAYALGGFFVCARLFRRRMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX8</accession>
    <name>Q63TX8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbp</name>
        <name evidence="7" type="ordered locus">BPSL1839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108438.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1839"/>
    <dbReference type="EnsemblBacteria" id="CAH35838">
        <property type="protein sequence ID" value="CAH35838"/>
        <property type="gene ID" value="BPSL1839"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1839"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2071"/>
    <dbReference type="eggNOG" id="COG1613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KDFGGWK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266580" evidence="6">
        <location>
            <begin position="18"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="327" mass="35527" checksum="38146D28DB16F577" modified="2004-10-25" version="1">MALGAAAALGALTPALADTTFLNVSYDPTRELYQDVNQAFGKEWKARTGETVNFKQSHGGSGAQARSVLDGLQADVVTLALAYDIDALANKGLVSKDWQKRLPDNASPYTSTIVFLVRKGNPKGIKDWDDLVKPGVSIVTPNPKTSGGARWNYLAAWAYAQHQPGGTAQTAKDFVTKLYRNAGVLDSGARGATTSFVQRGIGDVLIAWENEAFLSIKEFGADKFEIVVPSASILAEPPVAVVDKVVDKKGTRKLADAYLNFLYSRQGQEIAARNYYRPRSRDVPAALTKQFPKLKLYTVDDTFGGWTQAQKTHFADGGVFDSIYKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U53</accession>
    <name>Q63U53_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exported chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108363.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1763"/>
    <dbReference type="EnsemblBacteria" id="CAH35762">
        <property type="protein sequence ID" value="CAH35762"/>
        <property type="gene ID" value="BPSL1763"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1763"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1979"/>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGMNDVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267149" evidence="3">
        <location>
            <begin position="33"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="34"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="457" mass="47124" checksum="3B15D42D229CCE6E" modified="2004-10-25" version="1">MERTMNFSMLSRIVPRALAAGCLFAAAGASQAAGVYAPYVDVTLYPTPLVDQIGVQQGIQQFMLAFVVSGGNQCTPSWGGVQPIGNGATGDLLDKIATSVTAYRAKGGDVAVSFGGAAGQPLMQACSSVAALKGAYQTVIDTYSLTHVDFDIEGASQQDSAAVARNFQAVAQLQADYAAKGKPLHVTLTLPAMPTGLVQDGLNVLNAALANNVTLDAVNIMTMDYGPSGIDMGAAAISAAQGLYSQLDTAYKSAGKPQTDAQLKQLVGVTPMIGVNDVAGEIFTLANAQSVQTMAANNNYGFVGIWSITRDKACDGSSQYASPICSGVAQQPYAFSSVFKQLGGHWGAGVTQDPNYGGGSDGGGKPQPGAPWSATQVYTAGATVTYQGTTYQAQWWTQGDIPGQASVWKPVGGNVPAWSSTTAYPGGACVTYQGAKYCAKWWTQGDVPSAGGPWARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB3</accession>
    <name>Q63UB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531304.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108303.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1702"/>
    <dbReference type="EnsemblBacteria" id="CAH35699">
        <property type="protein sequence ID" value="CAH35699"/>
        <property type="gene ID" value="BPSL1702"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1702"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3784"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHDGMPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="197" mass="21893" checksum="99F25A1F291699D6" modified="2004-10-25" version="1">MKIGYARVSTEEQNLALQRDALMRAGCKRIFTDRGVSGTEFDRPGLNRALASLRAGDTLVVWRLDRLGRALPKLVGLVQQLSLREIQFESLTEAMTTNSSSGMLVFHMMAALAQFERSLISERTCAGMAAARARGQILGRRPALNEKQRAQALKLLLTQPIKCVAKQFNVHPRTLQRLQKAHQATAVALRPNSIFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UG2</accession>
    <name>Q63UG2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527060.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108254.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1644"/>
    <dbReference type="ESTHER" id="burps-q63ug2">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35641">
        <property type="protein sequence ID" value="CAH35641"/>
        <property type="gene ID" value="BPSL1644"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1644"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3719"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EAWAPQI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="31346" checksum="2BCB4304592C3C92" modified="2004-10-25" version="1">MKPERALDRDAARGDAAGTRYSIYPPQAGEACETVVLIHGVGMNHSVWSPQIDALTARHRVVAYDMLGHGGSALPTVAPTLDEYASQLERLLDALQIEQAHVIGHSMGALVALEFALTHPNRTISVVALNAVYDRTPGQREAVMNRAATLGDAPAAAGIDVTLERWFGDPIPAHLTKAAEAVRDLLLTVDPVGYARTYELFARSDDAHVGRLSNLAVPALFLTGEYDANSNPAMSLAMAAAAPYGRAQIIANERHMMNVTNPAQVNERLLEFLLSASAVSTVGDRHGDAGGCHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UN9</accession>
    <name>Q63UN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">potH</name>
        <name evidence="6" type="ordered locus">BPSL1557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521363.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108177.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1557"/>
    <dbReference type="EnsemblBacteria" id="CAH35558">
        <property type="protein sequence ID" value="CAH35558"/>
        <property type="gene ID" value="BPSL1557"/>
    </dbReference>
    <dbReference type="GeneID" id="56529282"/>
    <dbReference type="KEGG" id="bps:BPSL1557"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3603"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELYHTNT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="309" mass="34645" checksum="11BA76F5601899DC" modified="2004-10-25" version="1">MNALSSLFAWPVRKFGLTGRTAVIAGPFFWLVLFFLVPFVLVVKISFAQLQLGIPPYTELTALADGVLSIKLNLQHYAFLFSDSLYFATYVNSVVVAAVTTLLCLLIGYPMAYYIARSNPGTRNLLMMAVMLPFWTSFLIRVYAWIGILKNNGLLNNFLLWTGLISTPIELYRTNVGVYIGMVYSYLPFLVMPLYAHLVKMDLRLLEAAYDLGAKPWKAFVQITLPLSKNGIIAGCLLVFIPAVGEYVIPELLGGANTLMIGRVMWNEFFNNADWPMASAVTCAMVLLLLVPMAMFQHFQAKEQEGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UR7</accession>
    <name>Q63UR7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193775.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108149.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1529"/>
    <dbReference type="EnsemblBacteria" id="CAH35530">
        <property type="protein sequence ID" value="CAH35530"/>
        <property type="gene ID" value="BPSL1529"/>
    </dbReference>
    <dbReference type="GeneID" id="56595730"/>
    <dbReference type="KEGG" id="bps:BPSL1529"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3569"/>
    <dbReference type="OMA" id="PIDREEK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007420">
        <property type="entry name" value="DUF465"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038444">
        <property type="entry name" value="DUF465_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04325">
        <property type="entry name" value="DUF465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="71" mass="8428" checksum="D0B53FBE75A4BC5F" modified="2004-10-25" version="1">MQTRSAETQQELYNRLVSLQELHQQLAREIEQKEGRSDIDDLTLHRLKKEKLLAKDKIIMLQSQLEPDKRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-10-14" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UU3</accession>
    <name>PIMT_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="1">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcm</name>
        <name type="ordered locus">BPSL1503</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531391.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108123.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UU3"/>
    <dbReference type="SMR" id="Q63UU3"/>
    <dbReference type="STRING" id="272560.BPSL1503"/>
    <dbReference type="EnsemblBacteria" id="CAH35504">
        <property type="protein sequence ID" value="CAH35504"/>
        <property type="gene ID" value="BPSL1503"/>
    </dbReference>
    <dbReference type="GeneID" id="56529227"/>
    <dbReference type="KEGG" id="bps:BPSL1503"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3539"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000351834" description="Protein-L-isoaspartate O-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="322" mass="34158" checksum="010798ECAB491EA0" modified="2004-10-25" version="1">MSGERAKRFPLALEDLKREPRKPEGRVAERQAAGDAARQRLTAAAAVPAAASPIVPERRAPHGGVFAAKPARAKQHAPAAPGAAKRAPQGGAKQGDRSAAPNVALSGALALTSERVRERMVERLRANGVADPRVLAAMSAVPRHMFVDPGLAAQAYEDAALPIGHQQTISKPSVVARMIELAAAGRALERVLEIGTGCGYQAAVLSRVARDVYSIERVKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPAAAPFDAIVIAAAGLDVPRALLEQLAIGGRLVAPVGEQAGEQVLTLVERVAPAQWRESRLDRVFFVPLKSGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UX6</accession>
    <name>Q63UX6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539670.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108090.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1468"/>
    <dbReference type="EnsemblBacteria" id="CAH35470">
        <property type="protein sequence ID" value="CAH35470"/>
        <property type="gene ID" value="BPSL1468"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1468"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3499"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KFLWKML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="33470" checksum="171CA8009A15FD6F" modified="2004-10-25" version="1">MARIVLKIDVDTLRGTREGVPNLARIFDRFAARATFLFSLGPDHTGWAMRRVLRPGFLKKVSRTSVVEHYGVRQLLYGVLLPGPDIGRRARADMRAIHEAGFECGIHTWDHVYWQDNVRRRPREWTVREMDKSRERFVEIFGAPPVTHGAAGWQMNDAAFEQIDAWGMRYASDGRGHSPYLPVVAGKTLAHVQMPTTLPTLDEILGVDGIDTGNVAARVLEHTERNPHDQVFTLHAELEGQKLAPVFEQLLAGWRAQGHTFATMGDYYATLDRAALPSYPVAWGEIPGRSGELIVQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V65</accession>
    <name>Q63V65_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108001.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35376">
        <property type="protein sequence ID" value="CAH35376"/>
        <property type="gene ID" value="BPSL1376"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1376"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1543"/>
    <dbReference type="eggNOG" id="ENOG50302TT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FESRTYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9980" checksum="70809B2A41DEBA5C" modified="2004-10-25" version="1">MCGDVGARLRVRARMSYYVDVALCPFERRTAMDAESIAGLIGLGIGLLVLVSLSVYESREYKRAHNGEGMIHHWMAEHHLLDWRRKH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V86</accession>
    <name>RLME_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="1">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmE</name>
        <name evidence="1" type="synonym">ftsJ</name>
        <name evidence="1" type="synonym">rrmJ</name>
        <name type="ordered locus">BPSL1355</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193119.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107980.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V86"/>
    <dbReference type="SMR" id="Q63V86"/>
    <dbReference type="STRING" id="272560.BPSL1355"/>
    <dbReference type="EnsemblBacteria" id="CAH35353">
        <property type="protein sequence ID" value="CAH35353"/>
        <property type="gene ID" value="BPSL1355"/>
    </dbReference>
    <dbReference type="GeneID" id="56595282"/>
    <dbReference type="KEGG" id="bps:BPSL1355"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.125"/>
    <dbReference type="eggNOG" id="COG0293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155485" description="Ribosomal RNA large subunit methyltransferase E">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="220" mass="24660" checksum="3400007DF00E234F" modified="2004-10-25" version="1">MAKNRFNQSWLHDHINDPYVKMAQREGYRARAAYKLKEIDEQDKLIRPGQVIVDLGAAPGSWSQYARNKLAQGKRRDAVREGGIDGTIIALDMLPMEPVADVHFIQGDFREESVLHQLEEVLAGRAVDLVISDMAPNLSGVAVADAARIEHVCDLALEFAQNHLKPDGALLVKCFHGSGYSQIVEKFKHQFKTVAPRKPKASRDKSSETFILGRHLKQPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VN8</accession>
    <name>RS15_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">BPSL1206</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185828.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107828.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VN8"/>
    <dbReference type="SMR" id="Q63VN8"/>
    <dbReference type="STRING" id="272560.BPSL1206"/>
    <dbReference type="EnsemblBacteria" id="CAH35201">
        <property type="protein sequence ID" value="CAH35201"/>
        <property type="gene ID" value="BPSL1206"/>
    </dbReference>
    <dbReference type="GeneID" id="60546711"/>
    <dbReference type="GeneID" id="66546641"/>
    <dbReference type="KEGG" id="bps:BPSL1206"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.320"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000115406" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10098" checksum="57E91F2C249833D4" modified="2004-10-25" version="1">MSVADIKKSEVVAQFARGANDTGSPEVQVALLTARITELTGHFKTHAKDHHSRRGLLRMVSRRRKLLDYLKGKDADRYRALIEKLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ2</accession>
    <name>Q63VQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107814.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1192"/>
    <dbReference type="EnsemblBacteria" id="CAH35187">
        <property type="protein sequence ID" value="CAH35187"/>
        <property type="gene ID" value="BPSL1192"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1192"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1319"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MACWLYE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="17382" checksum="492301074726FAB5" modified="2004-10-25" version="1">MRRRLAALAYEGLLLFGVVFFAGLMFGVALQQRNGLDHRNLLAGWIALVVGAYFVWFWTHGGQTLPMKTWRLRVETARGAPLSAGRALARYALGWLWFLPPLALHPLAGFPLLRTLAATAVWFALWALAARLHPSRQFPHDRLAGTRIVDTPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU1</accession>
    <name>Q63VU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL1153A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107775.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1153A"/>
    <dbReference type="EnsemblBacteria" id="CAH35148">
        <property type="protein sequence ID" value="CAH35148"/>
        <property type="gene ID" value="BPSL1153A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1153A"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.385"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="11348" checksum="1753343D6CA5531E" modified="2004-10-25" version="1">MMRPFKKPLQPVNRRAYTFAVAETTAARGDSRQMLADDRRSAVFLRPYAFAHLFYGWAMAGERSRSPVPTFRSVNPVMCPPTPFDSGARAFNINVGGRYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU9</accession>
    <name>Q63VU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936863.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107767.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1146"/>
    <dbReference type="EnsemblBacteria" id="CAH35140">
        <property type="protein sequence ID" value="CAH35140"/>
        <property type="gene ID" value="BPSL1146"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1146"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.394"/>
    <dbReference type="OMA" id="KATHDYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="182" mass="20483" checksum="A995D8348E504A71" modified="2004-10-25" version="1">MTKKGWSDPLGAHVRLYHSLLNTPAWRVLGPSAVKLYIDMRMAMNGSNNGSIGASLSLMKHKGWTAPTTLAKALYELRALGFIAVTIEGGLRQGSRVPSLYRFTDVEVYEQPKTGVQAIKATHDYRAFESVREAERALTEGLERLRTEGRKKQQTRKKAPVQKTYPSNTESVPEDQNFQYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VV4</accession>
    <name>Q63VV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936858.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107762.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1141"/>
    <dbReference type="EnsemblBacteria" id="CAH35135">
        <property type="protein sequence ID" value="CAH35135"/>
        <property type="gene ID" value="BPSL1141"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1141"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.400"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="59" mass="7035" checksum="4D86DB23C6A1098B" modified="2004-10-25" version="1">MQTYEVAVAFPYKGRMRQVGERIEVEQEQHVALLRLLDKIRDAVPKRSTYMRRDMRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VW8</accession>
    <name>Q63VW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198110.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107748.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1126"/>
    <dbReference type="EnsemblBacteria" id="CAH35120">
        <property type="protein sequence ID" value="CAH35120"/>
        <property type="gene ID" value="BPSL1126"/>
    </dbReference>
    <dbReference type="GeneID" id="56595075"/>
    <dbReference type="KEGG" id="bps:BPSL1126"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1243"/>
    <dbReference type="eggNOG" id="COG4129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWDIPLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="197" mass="21092" checksum="C2A62F6BB6533D88" modified="2004-10-25" version="1">MRRASPAPCLNEMETIKAFNEARRQIQESVLELFKGLSLRERLLQGVLMAVQAASGACLAYGIGRALHTEQAVWAAITAIAVTQHNYADTINLSRDQFIGAMVGGLIGFAGAATGAGHFVAYAITIVTAIICCWCLNVGSAARLGAITATIVLLFPGEGPLWDIPLVRLGEVTLGTACAMAVGWTMSRIERRWFAKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX9</accession>
    <name>TRHO_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name type="ordered locus">BPSL1116</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936832.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107737.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VX9"/>
    <dbReference type="SMR" id="Q63VX9"/>
    <dbReference type="EnsemblBacteria" id="CAH35109">
        <property type="protein sequence ID" value="CAH35109"/>
        <property type="gene ID" value="BPSL1116"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1116"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.432"/>
    <dbReference type="eggNOG" id="COG1054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDTHTNC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="PTHR43268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000161459" description="tRNA uridine(34) hydroxylase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <sequence length="299" mass="32949" checksum="88D9ED4DD8BA21CB" modified="2004-10-25" version="1">MTTVNLAAYRFVSLDSIEQWRPLVAARCNTLGLRGTILLAPEGINLFIAGPREATDAFVDYIRHDPLFEGKFADLPFKESLSDSQPFRRMLVRLKREIITMKKPAIKPELGRAPSVDARTLKAWLDQGHDDASRPVVMLDTRNAFEVDVGTFDRALDYRIDKFSEFPAVIEANRADLEGKTIVSFCTGGIRCEKAAIHMKDVGIENVYQLEGGILKYFEEVGGAHYHGDCFVFDYRTALNPQLAPTADVTCFACRAVVPADAQQSPLYVPGKCCPACHPGDSGTPGRRAEPGAEPARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W71</accession>
    <name>Q63W71_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative porphyrin biosynthesis related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL1017</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in a late step of protoheme IX synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526333.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107645.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1017"/>
    <dbReference type="EnsemblBacteria" id="CAH35013">
        <property type="protein sequence ID" value="CAH35013"/>
        <property type="gene ID" value="BPSL1017"/>
    </dbReference>
    <dbReference type="GeneID" id="56526818"/>
    <dbReference type="KEGG" id="bps:BPSL1017"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.551"/>
    <dbReference type="eggNOG" id="COG3071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGKARDY"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042168">
        <property type="term" value="P:heme metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005254">
        <property type="entry name" value="Heme_biosyn_assoc_TPR_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010817">
        <property type="entry name" value="HemY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07219">
        <property type="entry name" value="HemY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00540">
        <property type="entry name" value="TPR_hemY_coli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HemY_N" evidence="12">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="44461" checksum="745955324E041CB1" modified="2004-10-25" version="1">MTLRGIIWLAVLFAIAAALATVGRFDTGQVLIVYPPYRIDVSLNFFVLAIIVAFIVLYALMRIVRNVWRMPQRVAAYRARMRNERAQAALRDALANLYAGRFSRAEKAARDALAVDANQSAASLVAAAATHRMHEYARRDEWLAKVSGQEWQDARLLATADMRADGRDAEGALAALAEMQASGGKRIHAQQIALRAQQQNKNWAEVLKIAKALEKREALHPAAAVRLRQQAAEHLLRDRRHDADALLEVWQSLSAAERQSPRLADLAAELLIALERRQEARRIVEDALAHNWNARLLRRYPDTAGADALPLIQKAEGWRRERPDDADLLFALGRLCQQQQLWGKAQSFLESALKLADDEPLRIRAHRALARLFEHLGETDKAAQHYRESALAITVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WF5</accession>
    <name>Q63WF5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186473.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107561.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0933"/>
    <dbReference type="EnsemblBacteria" id="CAH34928">
        <property type="protein sequence ID" value="CAH34928"/>
        <property type="gene ID" value="BPSL0933"/>
    </dbReference>
    <dbReference type="GeneID" id="56595023"/>
    <dbReference type="KEGG" id="bps:BPSL0933"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.647"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEITIGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="32215" checksum="BCF4B2192939B90B" modified="2004-10-25" version="1">MNAAPDSAAMSLDIVLLRTFLEVADRRGFAPAAERLALTPSAVSGHIKRLEQATGAVLLARTTRRVELTQAGETLYAYARNIVEMEREARARLRGSPLHGRLRIGASEDFAGAWLPQVLHTFGRLHPRATIELKVGITAELLRQQASGRLDVVFGKHCSRLDDEAGELLWEEPLVWAFASDAVLDANDALPLALFPQPCVYREAALAALNGALRPFRIAFESGSMAGCISAALAGFALTVVARSQLRHGLRECGPDDALPALPAARFYAFPHRPTPAGTALIDAVRETGRRRGFAPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WK8</accession>
    <name>Q63WK8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185910.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107508.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0883"/>
    <dbReference type="EnsemblBacteria" id="CAH34875">
        <property type="protein sequence ID" value="CAH34875"/>
        <property type="gene ID" value="BPSL0883"/>
    </dbReference>
    <dbReference type="GeneID" id="56594740"/>
    <dbReference type="KEGG" id="bps:BPSL0883"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.709"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="5">
        <location>
            <begin position="151"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="27055" checksum="4943A21C1E9536C0" modified="2004-10-25" version="1">MHPLFEPYRPQLDAHPWFGALPAELRDALTAAALPRRLVTGQVLFRRGDAPCGLYAVLSGALSVGAVDASGKEALLTVAEPTTWFGEIALFDELPRTHDAIALEDALLMHVPQAALQQLLDETPRYWRYFALLMAQKLRMSFMNVEALTLMPAAQRLAARLLMIAEGYGGIGTRHRRIRLSQERLGAMLSLTRQTANQLLKDLAARGVVRLHVGEIEVVDLDALRAASGAANRARSDGAGGAGGAGGTNEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WM2</accession>
    <name>OTC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="2">OTCase</shortName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argF</name>
        <name type="ordered locus">BPSL0869</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190177.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107494.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WM2"/>
    <dbReference type="SMR" id="Q63WM2"/>
    <dbReference type="STRING" id="272560.BPSL0869"/>
    <dbReference type="EnsemblBacteria" id="CAH34861">
        <property type="protein sequence ID" value="CAH34861"/>
        <property type="gene ID" value="BPSL0869"/>
    </dbReference>
    <dbReference type="GeneID" id="56596493"/>
    <dbReference type="KEGG" id="bps:BPSL0869"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.727"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112902" description="Ornithine carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <sequence length="309" mass="35418" checksum="A5868C5D3AD7D582" modified="2004-10-25" version="1">MTAKTIRHYLQFKDFSLEDYEYVLERTGILKRKFKNYETYHPLHDRTLAMIFEKSSTRTRLSFEAGIFQLGGHAVFMSTRDTQLGRGEPVEDSAQVISRMVDIIMIRTFEQDIIQRFAENSRVPVINGLTNEYHPCQVLADIFTYYEHRGPIRGKTVAWVGDANNMLYTWIQAARILGFKLRLSTPPGYALDTKLVDAESAPFYQVFDDPNEACKGADLVTTDVWTSMGFEAENEARKQAFADWCVDEEMMSHAHPDALFMHCLPAHRGEEVTAGVIDGPQSVVWDEAENRLHVQKALMEFLLLGRLNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WM4</accession>
    <name>Y867_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein BPSL0867</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL0867</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189237.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107492.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WM4"/>
    <dbReference type="SMR" id="Q63WM4"/>
    <dbReference type="STRING" id="272560.BPSL0867"/>
    <dbReference type="EnsemblBacteria" id="CAH34859">
        <property type="protein sequence ID" value="CAH34859"/>
        <property type="gene ID" value="BPSL0867"/>
    </dbReference>
    <dbReference type="GeneID" id="56596495"/>
    <dbReference type="KEGG" id="bps:BPSL0867"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.729"/>
    <dbReference type="eggNOG" id="COG1666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SDFDRQE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000261923" description="UPF0234 protein BPSL0867">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <sequence length="161" mass="18036" checksum="E7EE5DEA6F3CB106" modified="2004-10-25" version="1">MPSFDVVSEANMIEVKNAVEQSNKEISTRFDFKGSDARVEQKERELTLYADDDFKLGQVKDVLIGKMAKRNVDVRFLDYGKIEKIGGDKVKQVVTIKKGVSGDLAKKVVRIVKDSKIKVQASIQGDAVRVSGAKRDDLQSTIALLRKEVTDTPLDFNNFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X39</accession>
    <name>Q63X39_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189074.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107327.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0698"/>
    <dbReference type="EnsemblBacteria" id="CAH34691">
        <property type="protein sequence ID" value="CAH34691"/>
        <property type="gene ID" value="BPSL0698"/>
    </dbReference>
    <dbReference type="GeneID" id="56596606"/>
    <dbReference type="KEGG" id="bps:BPSL0698"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.919"/>
    <dbReference type="eggNOG" id="COG1276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLGWLLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="197"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="308" mass="30525" checksum="D452D19CAF939961" modified="2004-10-25" version="1">MKLDSLWFGQAALAALGDVAFAVALGSAFIGAWLANDGARSVIAPSHPAWRQSLRSLAVAAAVLVLADAGWLVYQAASMSGAGLRGAFGAMPTVLAQTHVGHAWAVACGGALLLLAVALARPSGPLAGALLALATLVVAAGKASLGHAADSGAFSAAVGVQTVHVAATAVWGGLVIAGGMAVLPALGSSIARGAMIRIAQRLSGASIAALAFVIVTGALNTVRGTGGDFAALDGSTWGRVLLLKLALVALALVLAALNRFSALPRLRRTASTEDAHTFRNVLHLEALAMIGVFIAAAVLSSTAPIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X60</accession>
    <name>Q63X60_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522783.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107306.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0677"/>
    <dbReference type="EnsemblBacteria" id="CAH34670">
        <property type="protein sequence ID" value="CAH34670"/>
        <property type="gene ID" value="BPSL0677"/>
    </dbReference>
    <dbReference type="GeneID" id="56527112"/>
    <dbReference type="KEGG" id="bps:BPSL0677"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.941"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMLIQIE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="222" mass="23822" checksum="80CE750045456602" modified="2004-10-25" version="1">MHSPLALVRDVSSQDAAAAADADASHAPFDALERLVGVNLARLRAERQLSLDALARLSGVSRAMLAQIESARSVPSIKVLCKVAAALKVSVAAFLRRHAVNGFEHLSAERAVRVVSSNGRFSARALYPEGEPAVAEFHELRIAPLHTEHGAPRAPGTSVNLVVSEGTLEVSIHERRQLLATGDAIVFDADQPYTLRNPGDTEARAFRVTVNAEVPPRWHVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X80</accession>
    <name>Q63X80_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540965.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107286.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0657"/>
    <dbReference type="EnsemblBacteria" id="CAH34650">
        <property type="protein sequence ID" value="CAH34650"/>
        <property type="gene ID" value="BPSL0657"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0657"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.963"/>
    <dbReference type="eggNOG" id="COG3178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HSRNLMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="344" mass="38625" checksum="663B29E02B1C5229" modified="2004-10-25" version="1">MTQPPADPRLARLTAWLATFADRYALELASLAPASADASFRRYFRVASAAAPGGAAIAVDAPPPERCREFAQIAQLLDAAGVHVPKVLEHDFDAGFMLVTDLGTRPYISALDPAAPAAARPLMRDALDALIRWQRASREGVLPPFDEAFLRREMALMPEWYVGRHLGKALSDDARGVLDRTFALLAASAKAQPQGYMLRDFMPRNLMIAEPNPGVLDFQDAVYGPLTYDVVSLLRDAFISWDEEFELDCFAYYWEQAKKAGLPVEPDFGEFYRQLEWMGLQRHIKVLGLFARINYRDHKPHYLADLPRFLGYARRVALRYRPLAPFAKLLDDLEGKTADVGYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XE4</accession>
    <name>Q63XE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107221.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0592"/>
    <dbReference type="EnsemblBacteria" id="CAH34585">
        <property type="protein sequence ID" value="CAH34585"/>
        <property type="gene ID" value="BPSL0592"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0592"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.640"/>
    <dbReference type="OMA" id="RTGMNQE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="127" mass="13236" checksum="55229B33A8DD7FD7" modified="2004-10-25" version="1">MCFVLPTTTEQRTGMNRELLTHIRADQLDGSIFDASCHAVTVGPVTVEFRTSAEPPSSTAELYISRQLVGGCTVNAAHPSGKFGGSVGKLKAEVDLTLDVPGGKLDYKLTVCAPIIGGTSKSGTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XL2</accession>
    <name>Q63XL2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195230.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107153.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0528"/>
    <dbReference type="EnsemblBacteria" id="CAH34517">
        <property type="protein sequence ID" value="CAH34517"/>
        <property type="gene ID" value="BPSL0528"/>
    </dbReference>
    <dbReference type="GeneID" id="56593805"/>
    <dbReference type="KEGG" id="bps:BPSL0528"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1120"/>
    <dbReference type="eggNOG" id="COG2802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANRWCEL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="210" mass="23297" checksum="7074DCB5C61E367E" modified="2004-10-25" version="1">MSSLSTTLIDLPLFPLHTVLFPGGLLPLKVFEARYLDMARACLRDDAPFGVCLLKSGPEVAQEGEVSVPETIGCMARIVECDTGEFGMLLLRTIGTQRFELLSHRVEANGLLVGIAEPMQEDIPLEGDSALAQFGACAEALERIVEVLRRSDAELPFAEPFRFDDPTWVSNRLAEVLPLDLRARQKLMEFPDVGARIDAVHRELNRHGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y98</accession>
    <name>Q63Y98_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106917.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34279">
        <property type="protein sequence ID" value="CAH34279"/>
        <property type="gene ID" value="BPSL0290"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0290"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.312"/>
    <dbReference type="eggNOG" id="COG4676">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYANFET"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267694" evidence="1">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="277" mass="29499" checksum="649ED7B64396A351" modified="2004-10-25" version="1">MKKLVTLMIAGALVALPCTTNLNAAQAATRAPAVAGSPGSAIVFVNGINNTFDDAIASLQVLKTQLNARDANNAYVYGNAYNATQGAFSDLWQVFKQKSVEGTSPADFWRAIDGGTVPAGGMDAALQQKYIDILTKSETPELPDHLNQYRAYLQQNRKVVLVGHSQGTLYANFEMNLLITGPERAQGRISSVNVGNAARYLLPGSSYLTSSSDTVIGSLGLVQTVMPSNFSLGLHLFTDPLGHSFTKIYLNPSFSAARQILTQVSQQANSAAKAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YG7</accession>
    <name>Q63YG7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198969.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106848.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0219"/>
    <dbReference type="EnsemblBacteria" id="CAH34207">
        <property type="protein sequence ID" value="CAH34207"/>
        <property type="gene ID" value="BPSL0219"/>
    </dbReference>
    <dbReference type="GeneID" id="60547679"/>
    <dbReference type="GeneID" id="60976633"/>
    <dbReference type="GeneID" id="64459839"/>
    <dbReference type="GeneID" id="66548585"/>
    <dbReference type="KEGG" id="bps:BPSL0219"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1493"/>
    <dbReference type="eggNOG" id="ENOG5034BSI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAMVAWY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="70" mass="7420" checksum="3D13C2FD3069D332" modified="2004-10-25" version="1">MHVGSIVCTTHIAVPKGARGIVQRILGDMAMVTWYAGVPGESKELNTEPFFLEDLIDTGESVLPAGAALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK9</accession>
    <name>Q63YK9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ordered locus">BPSL0178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189241.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106806.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0178"/>
    <dbReference type="EnsemblBacteria" id="CAH34165">
        <property type="protein sequence ID" value="CAH34165"/>
        <property type="gene ID" value="BPSL0178"/>
    </dbReference>
    <dbReference type="GeneID" id="56596700"/>
    <dbReference type="KEGG" id="bps:BPSL0178"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1542"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDVKESW"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030977">
        <property type="entry name" value="QueE_Cx14CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00376">
        <property type="entry name" value="7-carboxy-7-deazaguanine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04508">
        <property type="entry name" value="queE_Cx14CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
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    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
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            <begin position="48"/>
            <end position="50"/>
        </location>
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    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
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            <begin position="133"/>
            <end position="135"/>
        </location>
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    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
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            <begin position="173"/>
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        <ligand>
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        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <note>4Fe-4S-S-AdoMet</note>
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        <location>
            <position position="46"/>
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        <ligand>
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        </location>
        <ligand>
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        <ligand>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="210" mass="23237" checksum="A674352B2D6AF9B7" modified="2004-10-25" version="1">MTYTVKEIFYTLQGEGANAGRPAVFCRFAGCNLWTGREADRDGAVCRFCDTDFVGTDGENGGKFKDAASLAARIASLWPAGEAYRFVVCTGGEPMLQLDQPLVDALHAAGFTIAIETNGSLPVLESIDWICVSPKADAPLVVTKGNELKVVVPQDNQRLADYAKLDFEHFLVQPMDGPSRELNTRLAIDWCKRHPRWRLSMQTHKYLNIP</sequence>
</entry>
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    <accession>Q63YL6</accession>
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        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
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                <person name="Thomson N.R."/>
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                <person name="Beacham I.R."/>
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                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
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            <dbReference type="PubMed" id="15377794"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">K96243</strain>
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    </dbReference>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
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                <person name="Crossman L.C."/>
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                <person name="Churcher C."/>
                <person name="Mungall K."/>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="37" mass="4253" checksum="0900DE1D02A59376" modified="2004-10-25" version="1">MADIATVFGWTPHDMAAFSLAELMDWRERARIRSGNE</sequence>
</entry>
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    <accession>Q63YP4</accession>
    <name>Q63YP4_BURPS</name>
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            <fullName evidence="1">Hypothetical phage protein</fullName>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Peacock S.J."/>
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                <person name="Crossman L.C."/>
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                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
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                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
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                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
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                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
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            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
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    <dbReference type="EnsemblBacteria" id="CAH34130">
        <property type="protein sequence ID" value="CAH34130"/>
        <property type="gene ID" value="BPSL0143"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0143"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1578"/>
    <dbReference type="eggNOG" id="ENOG5033AB4">
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    <dbReference type="OMA" id="CATANGM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="166" mass="18528" checksum="287777F3E611DE3A" modified="2004-10-25" version="1">MKFIYQKYQGEFTEYELMSWAENGNYIQGVCVRSNAYKTFRKDRVSSYLDGSDTLLTAPYVTEDARIPVRREQASRINRGEPPPPGVPQILFTGFPAAQRAEMEALATEAGLYVRKSGVTRGLTFLCIGPNAGPAKVKQAREQGTYIVPATHFDVLIETGELPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YQ1</accession>
    <name>Q63YQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical phage protein</fullName>
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        <name evidence="1" type="ordered locus">BPSL0136</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549898.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106764.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0136"/>
    <dbReference type="EnsemblBacteria" id="CAH34123">
        <property type="protein sequence ID" value="CAH34123"/>
        <property type="gene ID" value="BPSL0136"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0136"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1585"/>
    <dbReference type="eggNOG" id="ENOG503173U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWDCEND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="72" mass="7965" checksum="AE6DB119E7D3B1F3" modified="2004-10-25" version="1">MATSAAAPLIFPFIVSDLPLEKRREYLRKLWNADVDAIVFLGAARKLGYALGGRWDAATDMPALVPTIRLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z22</accession>
    <name>Q63Z22_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Type II secretion system protein K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gspK</name>
        <name evidence="14" type="ordered locus">BPSL0015</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GSP K family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551121.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106640.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0015"/>
    <dbReference type="EnsemblBacteria" id="CAH33998">
        <property type="protein sequence ID" value="CAH33998"/>
        <property type="gene ID" value="BPSL0015"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0015"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.15"/>
    <dbReference type="eggNOG" id="COG3156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THYFLVY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038072">
        <property type="entry name" value="GspK_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002786">
        <property type="entry name" value="XcpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158544">
        <property type="entry name" value="SSF158544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="38214" checksum="7EDBE0F82CC2672F" modified="2004-10-25" version="1">MHRERGVAIINALLVVALSAILVSGMLWRQQVQVRRIENQRLLAQAQWVARGALDWTRMVLRSEGDTAPGITYLGGIWAVPIAKTKLSDFLGRIGVTDSAEGSDTYLSGSIEDAQAKFNLRNLVLSPAPGALQLNAAQVQTFQRLLATLGLDQQLAKIVARRVRAGLKQSATRFQAAQLPGAASGVPVPLPDGGTESGGNFTDEPGIAGGEGRGPAPLMMTSVDSLLDVEGFTPEMVERLRPFVTVLPTVTPVNLNTAPAEVIAALVPGMSVSSAQALVSRRETVFFRNVGDVQLALRGSGAPNVNLDSSQIDVTSSYFIVHGRIEHDRAVVDRTSLVYRDPTTHTTRIVRIRDQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FD29</accession>
    <accession>Q63QL8</accession>
    <name>RL21_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">BPSL3005</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <title>Random sequencing of Burkholderia pseudomallei strain G9313 for clinical PCR development.</title>
            <authorList>
                <person name="Steiner B."/>
                <person name="Meyer R."/>
                <person name="Bowen M."/>
                <person name="Morrill W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>G9313</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF292383">
        <property type="protein sequence ID" value="AAG01347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194344.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109600.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FD29"/>
    <dbReference type="SMR" id="Q9FD29"/>
    <dbReference type="STRING" id="272560.BPSL3005"/>
    <dbReference type="EnsemblBacteria" id="CAH37016">
        <property type="protein sequence ID" value="CAH37016"/>
        <property type="gene ID" value="BPSL3005"/>
    </dbReference>
    <dbReference type="GeneID" id="58136715"/>
    <dbReference type="GeneID" id="66548403"/>
    <dbReference type="KEGG" id="bps:BPSL3005"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2264"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="PRO" id="PR:Q9FD29"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000269295" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="103" mass="11356" checksum="595FF4C2AED07285" modified="2001-03-01" version="1">MYAVIKTGGKQYKVAVGEKLKVEQIPADIDAEITLDQVLAVGEGESIQFGTPLVSGASVKATVVSHGRHAKVTIFKMRRRKHYQKHGGHRQNYTELRIDAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HX3</accession>
    <name>Q63HX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529505.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112299.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2296"/>
    <dbReference type="EnsemblBacteria" id="CAH39782">
        <property type="protein sequence ID" value="CAH39782"/>
        <property type="gene ID" value="BPSS2296"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2296"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5917"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DQMVMSP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="441" mass="45367" checksum="D8D0F4212C6C424E" modified="2004-10-25" version="1">MHIHPADVDDGALAAPIPRPYAWTVFALAFALLLSDYMSRQVLNAVFPLLKAAWGLSDTRLGSLSGIVALMVGTLTFPLSVLADRWGRVRSITLMAALWSVATLGCAAATSYGELLVARAFVGVGEAAYGSVGVALILGLFPPHLRSTLTGAFMAGGAFGSVLGMALGGAVATQLGWRASFGAMACLGFALVVCFRLVVTERRIAGSGARAARSGRERTPALAHASLRTVLAELFSTVSVVCAYVGSGLQLFIMGAVIAWMPSFLNRYYALPPDKAAAAAAGFVLLGGSGMIACGIVTDRLSRACPERKWAMAIVYCAISFALLAIGFRLSPGAPQLGLLALGMFVVAGTSGPAGAMVANLTPPSIHSPAFATLTLVNNLLGLAPGPLVTGFIADRIGLVGALQIAPLVALASAFAFAVGRFRYGDGLRRLNPLSPSAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I08</accession>
    <name>Q63I08_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS2261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205758.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112264.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2261"/>
    <dbReference type="EnsemblBacteria" id="CAH39747">
        <property type="protein sequence ID" value="CAH39747"/>
        <property type="gene ID" value="BPSS2261"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2261"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5865"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANACESQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PSDC" evidence="10">
        <location>
            <begin position="63"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="433" mass="47129" checksum="780FEE2CDEEA6912" modified="2004-10-25" version="1">MTNRTNATHATNATNATNAAREAAAERRRLGGWLPAEEAALARYRKTLAAHAREHADGVPMTEAVRELAALAEGEPPLRMALTRAIDEARSRGYELGYETIGELMAVIDFVMTYAPPFSESGLVVCPLNALLDWPLCMPSGYAFFRDRAVNAQLKRVLNVWCGFLGGPHSRAHLNASEPDGWFSAEAVKRIGMSQFHCDPQLPYWGFASWNDFFTRRFLPDARPVATPDDPAVIVSACEAAPYHVAHDLKLLDTFWIKSQPYSLRDIFTAARGELARGFVGGSLYQAFLSAYDYHRWHAPVAGRIAHAYLVDGTYYSSTEAEGADPAGLNDSQGYMTAVATRAVIVIDADAPEIGRVACVFVGMGEVSSCMIDALPGQHVEKGEEIGYFQYGGSTYCMLFEPGVIGSFVAHPRYHEGAPAVQVNAEVAAVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I17</accession>
    <name>Q63I17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LPS biosynthesis related glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523309.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112255.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2252"/>
    <dbReference type="EnsemblBacteria" id="CAH39738">
        <property type="protein sequence ID" value="CAH39738"/>
        <property type="gene ID" value="BPSS2252"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2252"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5855"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACRPCMF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="39766" checksum="9631CD4371DED387" modified="2004-10-25" version="1">MSGDPSARPAAAERRGTGEYASIAVFRALQLGDMLCAVPALRALRRGEPQARITLIGLPWAKAFAERFSDYVDDFIAFPGAPGLVEQPHDVERLAAFVAECRSRRFDLAIQLHGSGAQSNAIVAGLGAASTAGFAPDAFAAGEHAAPRLDRTIAWPSALPEIARYTKLMRRLGYDDWGDYLEFPLGGLDYAICRVLCEQHDLRPREYAVVHPGARMQSRRWPVARFAGVARALAERGLRIVLTGTRGEAALADAFAAQLGAPFVDLCGRTPLGALGALIGRSRLVVCNDTGVSHVAAALGAPSVVIACGSDAARWAPLDRERHRVLADYPPCRPCMFETCPYDHACANAIGVEDVVRRADALLAVEPHHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IB7</accession>
    <name>Q63IB7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529374.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112155.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2154"/>
    <dbReference type="EnsemblBacteria" id="CAH39638">
        <property type="protein sequence ID" value="CAH39638"/>
        <property type="gene ID" value="BPSS2154"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2154"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5725"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CSFAAQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="28"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="476" mass="49656" checksum="5EAB5D5BBC073C5B" modified="2004-10-25" version="1">MKLDRSETLTDAHGGAPSKSERTPPRALVLPIVLGTLLNALNSSMIAVALVDIRRAFSGGGEVDVMWLVSGLYLATAVGQPMMGRLADGFGAKRVFLVGLAIVLAAAALAPWAPSLGWLVAARVMLGIGTSAAYPAGIAMIRAWSQRHARGETPTSSLGAISIAAQVAVAFGPPLGGLLVQYAGWRGVFWINVPLVIVAFVLGAARLPADAPRAAPRRPSLREQDWLGAALFVATLASLLSFLQTAFEAPDWPLLGACAAFGALLVGHERRVGEPLVDVRMLAGNRPLVATYLRCIGTYMVFYAIFYALPMWLQDVKGLAARDAGLVMLPISAFGTVTTLVATRLTHRRGSRPVLVFGSAMLCVGCGVMALMSADMPVWAIVPLSIVFGIPNGFNNLGNQATLYRSAPGERIGAAAGLYRTAQYVGGGLSFALVGIAFGHAASDRGLHALALSLLAVSALLLFNAASSRHIDAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC5</accession>
    <name>Q63IC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941182.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112147.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2146"/>
    <dbReference type="EnsemblBacteria" id="CAH39629">
        <property type="protein sequence ID" value="CAH39629"/>
        <property type="gene ID" value="BPSS2146"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2146"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5716"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MMNIMHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08417">
        <property type="entry name" value="PBP2_Nitroaromatics_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037402">
        <property type="entry name" value="YidZ_PBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="35511" checksum="B858CC3F529DEFD5" modified="2004-10-25" version="1">MNLRSIDLNLLVILDALLAERQVTRAGQRIGLTQPAVSNALGRLRYVFKDEILMRTPLGMELTPRAKVLACPIRQILQQIEELFVPENQFDSFTSDRRFTLRMSELTELLLLPPLLRNIRGTAPHIRMNVMHLNADKTVEALDSGRLDMAVCAGLDHPDAISSQVLFQDRLVCVLSRRHPDANRPLTLERFAALDFLNVSINPVDSSLIDTMLADMRFTRRIAFNVPHWLVVPSMLDALPLAVIMSERHALSLGDSRLAIRELPLDLEPVTWTLYWHRRYDNSVAHEWLRNCITDVVDAIQPRGVFEEASAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF7</accession>
    <name>Q63IF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539252.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112115.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2117"/>
    <dbReference type="EnsemblBacteria" id="CAH39597">
        <property type="protein sequence ID" value="CAH39597"/>
        <property type="gene ID" value="BPSS2117"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2117"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5663"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YADMEHV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="34318" checksum="D7FA7FCC8CB4598B" modified="2004-10-25" version="1">MDIKLDTPLLGALRCFEAAGRLGSFTKAADALHLTQSAISQQIRQLEARLGYPLFVRHARGLALTPKGGALHEATVAAFASLGRTLRQLSAPDAPLQVSCLPSFALQWLMPRLTEFHRLHPQTPVRLRAEFHAIDRETMSADDIDIAIRWDPFSYGALHVEPLFDESLVAAAAPAYLDRHPPRATAKWVSSVVPLHDASAWPEAPRYVEWRTWLDAVVPGYAGALRGPEFNLASLAIAAAVAGQGVVVCRQALVDDEIARGRLVNVFARRVPAPAQYKAICARPEDARVKAFVGWLRAESDSYAARRQTQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IP0</accession>
    <name>Q63IP0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552159.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112032.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2029"/>
    <dbReference type="EnsemblBacteria" id="CAH39507">
        <property type="protein sequence ID" value="CAH39507"/>
        <property type="gene ID" value="BPSS2029"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2029"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5557"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLENIIY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="129"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="236"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="390" mass="42754" checksum="087A33A765F5FDA8" modified="2004-10-25" version="1">MHRTTPNPAYYRPEHIELQDTLRRFVAKEISPYVNDWDEAGEFPRELYEKAARIGLLGIGFPDAYGGVEDVDMFHRLICSLELARCGAGGVVSSLMSHTIGAPPIAHAGSDALKARVLPGILAGRRISALAITEPGGGSDVAALRTSAMRDGDHYVVNGEKVFITSGMRADHYTVAVRTDAHAQGAKGLSLLLVDGDTPGLSKTPLKKMGWWASDTAHLRFDDCRVPAANLIGPEGGGFALVMQNFNLERFSLAASALGFAQVCYEDALDWARQRRTFGQRVADHQVIRHKLVDMATRIGATRAWLEQCAWQIDHVDRRAPELVATICILKNFATQTMQFCADAAVQILGGMGYMRGTRPERIYREVKVNMIGGGAEEIMKDLAARQLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IP5</accession>
    <name>Q63IP5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative zinc-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552154.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112027.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2024"/>
    <dbReference type="EnsemblBacteria" id="CAH39502">
        <property type="protein sequence ID" value="CAH39502"/>
        <property type="gene ID" value="BPSS2024"/>
    </dbReference>
    <dbReference type="GeneID" id="56531857"/>
    <dbReference type="KEGG" id="bps:BPSS2024"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5549"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNCNHRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="402" mass="42538" checksum="F1FDA6C9FA2B9621" modified="2004-10-25" version="1">MKAVVFHGIGDIRIDTVPDPGLAQTTDAVVRLTSSAICGTDLHMVRGTLGGMKPGTILGHEGVGLVEEVGRDVRNLRRGDRVLIPSTISCGHCAYCRAGYTAQCDTANPGGPLAGTAFFGGPQASGAFDGLQAEYARTPFAHASLIRLPDSLDDERAILMSDIFPTGYFGAQLAEVRMGDTVAVFGAGPVGQFAIASAKLMGAGRVIAIDRVVSRLEMACAQGAEVINFDDDDPVDTILQLTGGIGVDRVIDAVGVDAVRPTRGPAAPHDAQSRRAFDDEVRELAPRTRADGGHWVPGDAPSQVLQWAVRAVAKAGTVSIIGVYPMNDRFFPIGAAMNRNLTVKMGNCNHRAITPKLIEIVRSGAFDPITVLTQAEPLTSAIDAYRAFDTREPGWIKVKLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JA3</accession>
    <name>Q63JA3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533314.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111819.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1815"/>
    <dbReference type="EnsemblBacteria" id="CAH39291">
        <property type="protein sequence ID" value="CAH39291"/>
        <property type="gene ID" value="BPSS1815"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1815"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5258"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTLYPIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="429"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="529" mass="58168" checksum="FBE169B3D39A9909" modified="2004-10-25" version="1">MARHIVQAIQSHAFATPYKCALSDSRGDLGYADLDSFSTRFAMRLQDLGCRPGDRVVMLASRRALLVAAIIGVFKAGCVHVPLDPRMPADRLRYILHDVAPTLVIADEDLIDAIEHALPAAAPIVPVTELERLLDDADSPRLDALVQPLPLPPLDERAIAYCIYTSGSTGRPKGVLINHRSIADFFEGTRAVYDVTAQSRCASFSPLNFDVYLMDMLFPLAQGASLYVHDDVNAPDLLFDAIRAHDVTHFSAWGMMLGLIAQAEEFEAAPLPHLKTILTGTDVPDVKTVQRWLRKNAGVQVINAYGPTEATCAATAHVIREIEPERRTLYPIGKPLEHVLALLVDEGGNRITAPGVPGELMIGGTQVMQGYWNLPEETAARLVRLDGVPFYRTGDVCAYLADGSLYYMGRKDNEVKIGGYRIHLSEIQRVINSVPHVYGSEVVLLESRYGETLLAAGVLLERGAPLDADCKADEIRQRLAAELPAYMVPRHVKVLEQFPQLSSGKTDRKALLSILQQRINESNQEEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JF0</accession>
    <name>Q63JF0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sulfurtransferase (Cyanide detoxification)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190656.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111772.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1766"/>
    <dbReference type="EnsemblBacteria" id="CAH39241">
        <property type="protein sequence ID" value="CAH39241"/>
        <property type="gene ID" value="BPSS1766"/>
    </dbReference>
    <dbReference type="GeneID" id="56598193"/>
    <dbReference type="KEGG" id="bps:BPSS1766"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5197"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRPGHVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="171"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="289" mass="30969" checksum="43041D485F179DEA" modified="2004-10-25" version="1">MPHTHYTTLISADNLAERLAAAPGSVLVFDCRFDLADTDLGEQAYAAGHIPGAHYLHLDRDLSGAKTGTNGRHPLPARDALVDTLKAHGLRQNQQIVAYDAQGGMYAARLWWLLRWLGHDSVAVLDGGLQAWQSEGHAVSQDTPPKSMGDFRAGAPLATVVDAQTVLANLATKDRLVIDARAADRYRGENETIDRVGGHIPGALNRFFKDNLTADGRFKSGHELREAFSPLLGATEPKKVILQCGSGVTACHNALAMEIAGLHDPALYAGSWSEWSADPSRPVATGANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JZ8</accession>
    <name>Q63JZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable AMP-binding rotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551903.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111574.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1568"/>
    <dbReference type="EnsemblBacteria" id="CAH39041">
        <property type="protein sequence ID" value="CAH39041"/>
        <property type="gene ID" value="BPSS1568"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1568"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4935"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVWSGDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017529">
        <property type="entry name" value="AcylCoA_ligase_PEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03098">
        <property type="entry name" value="ligase_PEP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="443"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="535" mass="57661" checksum="719A23D909C85DA0" modified="2004-10-25" version="1">MRNFFDLVEQAACRTPDAEALVAGDARLTYRALAALGLAFAERLQALEIAQGERLAIFLDKRIETVVAMLGAAAAGVVFVPINPALKPEQVHHILVDSGARCLVTSSLRARILGDGVLAGMPYVILTDAKTLAPAPASRTTFLRWMQPDAPPESVANRHASAAPEPRADTIDADLAALLYTSGSTGRPKGVMLSHRNLLEGAWSVAQYLRHTAQDRILAALPLSFDAGLSQLTTAWAAGASAVLVNYLMPADVVEICVRERITGFAGVPPLWIQLARAAWPGEARARLRYFANTGGHLPRPVLHALRELFPSASPYLMYGLTEAFRSTYLDPAEVDRRPDSIGKAVPNARILVVREDGAPCAPNEVGELVHVGACVTLGYWNDPARTALRYRPSPEAKPGGAPRETAVWSGDLVRRDDDGFLYFVARNDAQIKSSGYRISPEEIEEVAHASGLVAEAVALGVPHDELGESITLVVVPLDADTFRPDALRARCAQQLPPYMVPHTIATRTSLPRNPNGKFDRVALRADAANLVETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K35</accession>
    <name>BIPC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>Effector protein BipC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">bipC</name>
        <name type="ordered locus">BPSS1531</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="FEMS Immunol. Med. Microbiol." volume="52" first="78" last="87">
            <title>Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents.</title>
            <authorList>
                <person name="Druar C."/>
                <person name="Yu F."/>
                <person name="Barnes J.L."/>
                <person name="Okinaka R.T."/>
                <person name="Chantratita N."/>
                <person name="Beg S."/>
                <person name="Stratilo C.W."/>
                <person name="Olive A.J."/>
                <person name="Soltes G."/>
                <person name="Russell M.L."/>
                <person name="Limmathurotsakul D."/>
                <person name="Norton R.E."/>
                <person name="Ni S.X."/>
                <person name="Picking W.D."/>
                <person name="Jackson P.J."/>
                <person name="Stewart D.I.H."/>
                <person name="Tsvetnitsky V."/>
                <person name="Picking W.L."/>
                <person name="Cherwonogrodzky J.W."/>
                <person name="Ketheesan N."/>
                <person name="Peacock S.J."/>
                <person name="Wiersma E.J."/>
            </authorList>
            <dbReference type="PubMed" id="17995960"/>
            <dbReference type="DOI" id="10.1111/j.1574-695X.2007.00345.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>IMMUNOGENICITY</scope>
        <source>
            <strain>K96243</strain>
            <strain>PHLS 79</strain>
            <strain>PHLS 91</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <text>Secreted via the bsa type III secretion system.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Human meliodoisis patients have detectable antibody response to BipC. However, BipC does not act as a protective antigen.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the invasin protein C family.</text>
    </comment>
    <dbReference type="EMBL" id="EF428329">
        <property type="protein sequence ID" value="ABO26349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EF428332">
        <property type="protein sequence ID" value="ABO26355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EF436254">
        <property type="protein sequence ID" value="ABO28815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203135.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111537.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63K35"/>
    <dbReference type="STRING" id="272560.BPSS1531"/>
    <dbReference type="EnsemblBacteria" id="CAH39004">
        <property type="protein sequence ID" value="CAH39004"/>
        <property type="gene ID" value="BPSS1531"/>
    </dbReference>
    <dbReference type="GeneID" id="56597876"/>
    <dbReference type="KEGG" id="bps:BPSS1531"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4886"/>
    <dbReference type="OMA" id="MEIQNTK"/>
    <dbReference type="PHI-base" id="PHI:5321"/>
    <dbReference type="PHI-base" id="PHI:7309"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005427">
        <property type="entry name" value="BacInvasinC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09599">
        <property type="entry name" value="IpaC_SipC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02101">
        <property type="entry name" value="IpaC_SipC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000344001" description="Effector protein BipC">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="419" mass="44323" checksum="53F278B1D41D7845" modified="2004-10-25" version="1">MSIGVQSSGINISHAELSRLVDAGKSEQGDKAVRDDGRALARADAALAAVVGERVAARRDAVAGSGAQRVELARPKPDAQTRATDRRTVSGLEREHKRLAASQTPRVTGMHDALVQRHVSLDGAKAAHGEGVKRAAGDAPRAAADAPQRFAFADDKAFDAMLALGAAMQKNVQSDLAMQGKLTMLAHDAMMSAAAQDRSIGAAQMTAAIAGGALQATTSLGGAMQQMKSLSTKSMSIEKELKPQAELKQFHAEQALELRGINKPVLSNDEVSHVKIKRDTGETVRHEIDHGGERMSDEHASVLAQEAPARQHRIDMHGMRHEENLVKAGRQQMKGDLLQSGGQIGKNQIDGASAQQQGADRAEQKEDENAQQTAMAAASTRDEAAHRSREAAQKAIDAAKSQVANDNAVAAQVAGNLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K51</accession>
    <name>Q63K51_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="9">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
            <shortName evidence="9">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">folE</name>
        <name evidence="11" type="ordered locus">BPSS1514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="9"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009968906.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111521.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K51"/>
    <dbReference type="STRING" id="272560.BPSS1514"/>
    <dbReference type="EnsemblBacteria" id="CAH38987">
        <property type="protein sequence ID" value="CAH38987"/>
        <property type="gene ID" value="BPSS1514"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1514"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4865"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WMTRDIA"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="10">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="210" mass="23629" checksum="4A69B41DBDF0AB0C" modified="2004-10-25" version="1">MIDTQYNGACDVHHHSPAEIRRIRQFDPAAFEMAVGSLLMACGIEIDAAHTSRTAQRVRELWQKRLLDGYDVDPAEALGMGFDDRKEDMVIIRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRFTYQEWITNEIATALVTHGKARGAACLIEAEQLCLLMGENRRGDERVITQCYVGEFDHNAQARNEFLRAINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K56</accession>
    <name>Q63K56_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536933.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111516.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1509"/>
    <dbReference type="EnsemblBacteria" id="CAH38982">
        <property type="protein sequence ID" value="CAH38982"/>
        <property type="gene ID" value="BPSS1509"/>
    </dbReference>
    <dbReference type="GeneID" id="56530077"/>
    <dbReference type="KEGG" id="bps:BPSS1509"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4856"/>
    <dbReference type="eggNOG" id="COG3522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHPWQVY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="465" mass="51863" checksum="2D3D39C0BFE36ADE" modified="2004-10-25" version="1">MDNVYWHQGMLLQPQHFQLAELHQQFRFEPWLACGPPHFWGVGALSLAQAAIDRRVVEIRSARLLFADRSYVEYPGNAVVAARAFDPAWLDEGRALVAHVALRRLARGANNVTVAAAPDALPDAPTRYATLPSAEEVADLHSDHPGAPVRTLKHVLKIVFEHELDALAAHETIPIARIVRDGERLRLDDDFAPPCYALSGSRTLLERVRCIRDELAGRARQLQQYKNPREMQRAEFDASYAAFLLALRSLNRFGPLLFHLAECDGQHPWTVYGVLRQLVGELSVFSERFDMLGETPDARGGLPPYDHRDLGGCFSRAHALIGHLLDEIAVGPDCVATFEPDGPQQPAQRSAQLPPDVFADRHQIYLAIRSAHDPDTLAQRFALGGRIAATDEMPQLTALALPGVELTRLPGPPPRLPRRGDARYFRIEQAGRPWDAIRRDGRVSLRWADAPDDLHAELVAVRHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KC6</accession>
    <name>Q63KC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative membrane-anchored cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSS1434</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205613.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111446.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1434"/>
    <dbReference type="EnsemblBacteria" id="CAH38909">
        <property type="protein sequence ID" value="CAH38909"/>
        <property type="gene ID" value="BPSS1434"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1434"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5674"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KTWSVNV"/>
    <dbReference type="PHI-base" id="PHI:4667"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008635">
        <property type="entry name" value="Coiled_stalk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024973">
        <property type="entry name" value="ESPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005594">
        <property type="entry name" value="YadA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13018">
        <property type="entry name" value="ESPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03895">
        <property type="entry name" value="YadA_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05662">
        <property type="entry name" value="YadA_stalk"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="ESPR" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="14">
        <location>
            <begin position="221"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="14">
        <location>
            <begin position="2304"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="14">
        <location>
            <begin position="2503"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_anchor" evidence="13">
        <location>
            <begin position="2575"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2460"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2533"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2465"/>
            <end position="2499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH38909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="2634" mass="247090" checksum="D6815A807E15410B" modified="2004-10-25" version="1">MNRSYRSIWNEALGAWVAASEISSARGKPNKSAVAKVVTAAVLAVVVQAAHASTIGVGTGSLPGGSACGGIGGTGIGPDGTTNYTNRAITDGSGFYSTVAGCSANGSNALGVTLYGAFTTVTGDGGTAMGFAAYAAKWASAVGLQASATGQSSSAFGFNALASGANSLALGSSSTAAYANSVAIGQGSVTGAAAPTGTGYLTGSAAPSSEVSVGSSTNLRRITNVADGSAANDAVTVAQLSTGMSTTTSAIASLSTSTSTGLSSARSSIASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTTNSNVASLSTSTSTGLSSANSSIASLSTSASSGISTAQSGVNSLSTGLSTTNSNVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTANSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTANSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTTNSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTDSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTTNSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTTNSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTANSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTVATTTNNLGSSTAAALGGGATYNPATGTISAPSYTTYNANGTTTANTSVGSAIDSINANGIKYFHANSAGPDSVATGADAVAIGTGATAATANSVALGANSVTAAAVPTSSATVGSTTLGTFAGSAPVGVVSVGAPGAERQITNVAAGQVTASSTDAINGSQLYAVASKLDSASSSISSLSTGLSSATSSITSLSTSTSTGLSSANSSIASLSTSTSTGIGSLSTGLSTTDSTVASLSTSTSTGLSSANSSIASLSTSTSTGIGSLSTGLSTTDSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSTSTSTGLSSATSSITSLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTANSTVASLSTSTSTGLSSANSSIASLSTSTSTGIGSLSTGLSTTDSNVASLSTSTSTGLSSANSSIASLSTSTSTGIGSLSTGLSTTDSTVASLSTSTSTGLSSANSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTTNSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTDSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTDSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSTSTSTGLSSTTSSIASLSTSTSTGIGSLSTGLSTTDSTVASLSTSTSTGLSSATSSIASLSTSTSTGIGSLSTGLSTTNSNVASLSSGLSSTNSSLTSLSTSASSGISTAQSGVNSLSTGLSTTNSTVASLSTSTSTGLSSANSSIASLSTSTSTGIGSLSTGLSTTNSTVASLSTSTSTSIGSLSTGLSSTNSNLVSLSTSASTGIGSLSTSIDTTNSNLASLSTSASTGIGSLSTSINATNSNLASLSTSASTGIGSLSTSISSITTNTTNLGNSTAAALGGGATYDPATGAISAPSYTTYNANGTTATNTSVGAAIDNINANGIKYFHANSTDPDSVATGTNSVAIGPNAVANVDYSVAIGSGATTSAAVPVASASVGGLTFGGFAGSAPIGVFSVGAPGAERQITNVAAGRISAASTDAVNGSQLYATNSNVASLSTGLNATNSNLASLSTSTSTAVGSLSTGLSTTNSTVASLSTSTSTSIGSLSTGLSTANSNLASLSTSTSTGIGSLSTGLATTNSNVASLSTSVTNINTQLTSLSTSITNNVIRSLPASTGVAADMSAPKATSPSVTAGSNSVALGAGSNDGGRSNVVSVGSDTQQRQITNVAAGTEGTDAVNVNQLNTLSTSMSQSLSNQQTQLNNLGSQLNQTQQQLQQTDTMARQGIAAVAAMASIPHMDRDSNFAMGVGTSSFLGQKAIAVGMQARITENLKASLNGGFAGNQKVIGAGMLYQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KH9</accession>
    <name>Q63KH9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Endonuclease/Exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205603.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111393.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1382"/>
    <dbReference type="EnsemblBacteria" id="CAH38854">
        <property type="protein sequence ID" value="CAH38854"/>
        <property type="gene ID" value="BPSS1382"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1382"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5612"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VASYNVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="35867" checksum="645E74F5ED95F2AE" modified="2004-10-25" version="1">MTPTMMPPDTPTPAGAPPNATTADDALRDVAPQTGARALGAAAARAQPRTRELRIATYNIHGGLGAWTASAAERIAVVLDELRADVIALQEVPLGGARGADVLAHLRACTGMHAAEGPTIDTPARRYGNAVLSRFPIRAARMLDLSFGNREPRGALDADIECGFGVLRVVATHLGLSATERSAQVARLLAAFDTRALPVILLGDINEWFVRGRALRALVTHFRRAPAPRTFPTLCPLFSLDRIWVHPGEWLVDVAPHRSARARRASDHYPLVARIRAAPETDADIAQAPASASRTPPERPCEPTDSTEPASTTGAPARSPATTPRCASSPSRRASSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KI7</accession>
    <name>Q63KI7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutathione-S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537174.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111385.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1374"/>
    <dbReference type="EnsemblBacteria" id="CAH38846">
        <property type="protein sequence ID" value="CAH38846"/>
        <property type="gene ID" value="BPSS1374"/>
    </dbReference>
    <dbReference type="GeneID" id="56530202"/>
    <dbReference type="KEGG" id="bps:BPSS1374"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4689"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWVHQLQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="27439" checksum="4D43EF57DEAFEB44" modified="2004-10-25" version="1">MRYELYYWPDIQGRGEFVRLALEAAEAEYVDIARESSRKGMGVPAMTRLLESDAMACLPFAPPFLKAGEQIIGQTANILLFLGARHGLAPRDDAGRLWAHQLQLTVADFVVEIHDTHHPIAGGLYYEDQKAEAAMRAEDFIEHRLPKFLGYFSRVLAHNPHKHGYMVGAHLSYVDLSMFQLIEGLRYAFPKAFARVAKQHAALIELGDRVAQHPPVARYLASARRIPFNEQGIFRHYAELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KK1</accession>
    <name>Q63KK1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative stress-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188566.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111371.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1361"/>
    <dbReference type="EnsemblBacteria" id="CAH38832">
        <property type="protein sequence ID" value="CAH38832"/>
        <property type="gene ID" value="BPSS1361"/>
    </dbReference>
    <dbReference type="GeneID" id="56597566"/>
    <dbReference type="KEGG" id="bps:BPSS1361"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4667"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECFIANS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="17800" checksum="3C39CAB34E687B00" modified="2004-10-25" version="1">MSTYTAEVAWQKQESETFADNRYSRKHEWRFDGGVRVPASSSPHVVRVPFSDPTAVDPEEAFVAALSSCHMLWFLSLAAQKQFVVTGYRDVAEGTMAKNAQGKAAMTRVVLRPHVTFGGERAPTRDDVDALHHAAHDACYLANSVRTDIDIEGSWAHAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM8</accession>
    <name>Q63KM8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184483.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111343.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1333"/>
    <dbReference type="EnsemblBacteria" id="CAH38804">
        <property type="protein sequence ID" value="CAH38804"/>
        <property type="gene ID" value="BPSS1333"/>
    </dbReference>
    <dbReference type="GeneID" id="56597536"/>
    <dbReference type="KEGG" id="bps:BPSS1333"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4632"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFETIHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="286" mass="31160" checksum="35A60089300ADB22" modified="2004-10-25" version="1">MSNQSIGAPDSTAVRVALWRALHARIDAPPHVLDDEIGLALAAPDDDWRSRPDMDPQASRGYRASIVGRARFVEDLVDEQADRGVAQYVVLGAGLDTFAQRRAKLASHLRVFEIDQPGTQAWKRQRLIALGYGVPQWLRLVPVDFETSGAWRAQLSAAGFDDSRPAVVSSTGVSMYLTREAIAGTLSQIATLAPGSTLAMTFLLPLELIDDPAERAQHAAVYERARAAGTPFVSFFSPSDMLALAREAGFREARHVSTDDLVRRYFESRPDGLRPASGEAFLVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L47</accession>
    <name>Q63L47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528392.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111174.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1161"/>
    <dbReference type="EnsemblBacteria" id="CAH38629">
        <property type="protein sequence ID" value="CAH38629"/>
        <property type="gene ID" value="BPSS1161"/>
    </dbReference>
    <dbReference type="GeneID" id="56530425"/>
    <dbReference type="KEGG" id="bps:BPSS1161"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4388"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HNVISDG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="23573" checksum="44CDF9D199381272" modified="2004-10-25" version="1">MIKVLIADDHALVRDGLRHILGAETGFEVVGEACDGISTIELTRSTDAQLLVLDLSMPGRNGIDLIRQIKEEKPALRILVLTMHAEQQYASRAFRAGASGYMTKESASAELVGALTKIAAGGLYVSLAMAERLAQSLNEPVESLPHQRLSDREFDVFRRIAAGETITEIAQALDVSAKTVSTYKARILEKMQMPHDAALVRYAIRHKLFDDGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LC0</accession>
    <name>Q63LC0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage tail-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009935906.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111101.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1088"/>
    <dbReference type="EnsemblBacteria" id="CAH38556">
        <property type="protein sequence ID" value="CAH38556"/>
        <property type="gene ID" value="BPSS1088"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1088"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4287"/>
    <dbReference type="eggNOG" id="COG3499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRYQYIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009734">
        <property type="entry name" value="Myoviridae_GpU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016912">
        <property type="entry name" value="Phage_P2_GpU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06995">
        <property type="entry name" value="Phage_P2_GpU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029208">
        <property type="entry name" value="Phage_tail_GPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="141" mass="15770" checksum="3D6B13CA7731F0A7" modified="2004-10-25" version="1">MLMSLDQFVFSLTSAPFRELQRRRTWKHPTSSRIGARDGRQFAGVGDDTITLNGLVAPETFGSIASIRELAAMADTGEAYVLVDGAGNVYGAYVIAELNETQSYHTADGTPRRIEFQLTIERVDDDVLRTTREKNTRKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LH3</accession>
    <name>Q63LH3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cobalt-zinc-cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">czcB</name>
        <name evidence="5" type="ordered locus">BPSS1042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551660.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111048.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1042"/>
    <dbReference type="EnsemblBacteria" id="CAH38503">
        <property type="protein sequence ID" value="CAH38503"/>
        <property type="gene ID" value="BPSS1042"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1042"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4230"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIPKREY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267334" evidence="3">
        <location>
            <begin position="25"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="177"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="489" mass="50781" checksum="64BB458D3D6EDBE6" modified="2004-10-25" version="1">MQRKPLILAGAAAAGALAIVLALARAPSTSSAPAASGAAAAAPASGATGPHGGAMFAQGALSAEIVLSEKPDDARLVVYPFVDGKPVEQGAAVSATLTRHDGERVALQFAQAGAKYTSAQPIARPHVFDASIDVRIGARSASFPFSRADGAIALDDAQLGAARIGIARAGPAQIITSFQLPGEIKFNEDRTAHVVPRVAGIVERVAVSIGENVKPGQVLAVIASTDLADRRSELMTAERRLQAARTSYAREKTLWEERISAEQDYLQAQVQLREAEIAAANARQKLAALNASAASGALNRYELRAPFAGTIVEKHIAPGEAIAADANVFVVSDLSSVWAEMAVPAQRLNEVRVGRHATVSAAAFESKSSGPIAYVGALLGEQTRTAPARVVLPNPDGAWRPGMFVNVTVDAGAQNVPVAIESDALQDVDGAPAVFVRTPKGFVAQAVETGRRDERRVEIVKGLAPGQTYAAANSFVLKAELGKGVADEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LX6</accession>
    <name>Q63LX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528152.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110895.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0886"/>
    <dbReference type="EnsemblBacteria" id="CAH38348">
        <property type="protein sequence ID" value="CAH38348"/>
        <property type="gene ID" value="BPSS0886"/>
    </dbReference>
    <dbReference type="GeneID" id="56530659"/>
    <dbReference type="KEGG" id="bps:BPSS0886"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7178"/>
    <dbReference type="eggNOG" id="ENOG5032XUU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWHRPAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032598">
        <property type="entry name" value="DUF4902"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16245">
        <property type="entry name" value="DUF4902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="147" mass="15865" checksum="3730319CEFF554FA" modified="2004-10-25" version="1">MNSPWLHRFRGSSTDGYVRLPMHAFAELRLVHVSSGIDSGLLVELRASDIDARIAGYTEWERPSSAGAAHLTVGWDWYIDGATGAFVIAWGDVRSNVMGVDGNGLDIGMDPTSAALSRRLAQLNWPSAVTAAMLRRGDFAHAGPTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M33</accession>
    <name>Q63M33_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BPSS0827</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205470.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110838.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0827"/>
    <dbReference type="EnsemblBacteria" id="CAH38289">
        <property type="protein sequence ID" value="CAH38289"/>
        <property type="gene ID" value="BPSS0827"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0827"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4911"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DDYANYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266155" description="Microbial collagenase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M9_N" evidence="14">
        <location>
            <begin position="97"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH38289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="645" mass="72040" checksum="F46F4980C29D3BDB" modified="2004-10-25" version="1">MTEVFRKTRRWSAVAALSAFVGLAGAASANTQPMQPTQQKQARMPRLPQNLPVSPEQAEYNLPLSEQDRAALTRPSPLKQPAKRGKRSAPGADCRDMSVMTQYRGAALADYIANLPDYECHYGLFSVDKTLAAQIFSAENVHAVASRFVQDIYRYDASNLILVNLLIYLRSAYYQYDVSGIANPIPNLAVWLRPYIKQSLEGAALYRENARAPSTANELMKLITNMKDEAFYLPTLKARIAFYTASATNPQAAAPLLQPSAAGGFTGLLTVFFYAHQRSGAQPMLDSDATLPETLNRFVTANRASLSNTSAAYQLADAARETFRFLRYPAQKPRVKKMIQDMLASTSMTGADSDLWLAAAEAVDYGDSGNCADYGTCDYKKRLTDAVLTHRYACNAGVRILAQDMTMPQLQSVCTSVAQQDDYFHRMMKTGRKPVAGDRNDTIELVIFDDYANYRKYASVIYGISTDNGGMYLEGDPSAPGNQARFIAHEASWLRPEFKVWNLEHEFTHYLDGRYDMAGDFAASTAKPTVWWIEGLAEYLSRKNDNQESIDAARTGAYRFSDVLGTLYSSSDYVARAYRWGYMATRFMFERHRADVDTIVSRFRVGDYDGYANYVAYIGNRYDGEFVDWARAATTAGEPPLPTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M53</accession>
    <name>Q63M53_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tyrB1</name>
        <name evidence="6" type="ordered locus">BPSS0808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200899.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110818.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0808"/>
    <dbReference type="EnsemblBacteria" id="CAH38269">
        <property type="protein sequence ID" value="CAH38269"/>
        <property type="gene ID" value="BPSS0808"/>
    </dbReference>
    <dbReference type="GeneID" id="56597128"/>
    <dbReference type="KEGG" id="bps:BPSS0808"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7073"/>
    <dbReference type="eggNOG" id="COG1448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDQNKRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="PTHR11879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="43354" checksum="8E58F64DAF4E7BDF" modified="2004-10-25" version="1">MFEHIDAYPGDPILTLNENFQQDPRTRKVNLSIGIYFDDDGRIPVMGAVREAEAIVQRESGPKPYLPMTGLAAYRDAVQAVVFGEGSDARAAGRIATVQTLGGSGALKVGADFIKRYFPHAQVWISDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAMLAAIDALPHKSVVLLHACCHNPTGVDLDDAQWLKLIDVLQARELLPFVDMAYQGFGAGLAADAFAIRELARRGMPAFVANSFSKNFSLYGERVGALSVICEDAAAAARVLGQLAGAVRSNYSNPPTCGAKIVAQVLTTPALRAQWEEELAAMCRRIAKMRSAIHDGLRAHVPAEALTRYVKQRGMFTYTGLTEAQVECLREQHGVYVLRSGRMCVAGLNEANVGIVADAIGAVIASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M66</accession>
    <name>Q63M66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative surface-exposed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSS0796</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110805.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0796"/>
    <dbReference type="EnsemblBacteria" id="CAH38256">
        <property type="protein sequence ID" value="CAH38256"/>
        <property type="gene ID" value="BPSS0796"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0796"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4871"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHSEASD"/>
    <dbReference type="PHI-base" id="PHI:4665"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008640">
        <property type="entry name" value="Adhesin_Head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008635">
        <property type="entry name" value="Coiled_stalk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005594">
        <property type="entry name" value="YadA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03895">
        <property type="entry name" value="YadA_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05658">
        <property type="entry name" value="YadA_head"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05662">
        <property type="entry name" value="YadA_stalk"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266986" evidence="12">
        <location>
            <begin position="19"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="798"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="1303"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1448"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1462"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="1548"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_anchor" evidence="13">
        <location>
            <begin position="1595"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH38256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1653" mass="151576" checksum="C37BC118BF932DD6" modified="2004-10-25" version="1">MIPLAIAVALMFSPYAWAGVGGADNGVTGTSNNGGVGGSSGGGGVQFSDMGVAFVGDGDCSMLTSGPGSYAGVYGSGSNYLGGLFGFGAQTSAVGWGTPSNAGANSGIVPYQGAAQTFGNVTYAGNGTQSGNFTQAFGLNSFAVGCGAHATGLSATAIGWGTTASGAGSVALGLYSTASGQGSLAFGTSATATATDTIALGTLATANAVSGVAIGANTQASAANATAIGGNSSGANLGAQATAAGATAIGGNATAGAAATATNAIAIGGQSSAKDANDVAVGVGARAGTGSGAGNDLAIGNGATATGGNSIAQGAGASANAAGAVAIGKSASAAGGQAVSIGVANTASGNGAVAIGDPNVATGTGAVALGNNNTANGQGAVALGNVSTAVGQGSVALGNSSNAAAAGGVALGDTASAVMAGGLALGSLATASNANDVALGAGSKTAAAVATSTVSVNGANYAVAGSGPASTVSVGAPGSERTITNVAAGQVSAGSTDAVNGSELYATNQAITTGLSTANSSIASLSTSTSTGLSSANSNIGSLSTGLSTANSTVASLSSSTSTGLSSANSAVASLSTSTSTGLSSANSNIGSLSTGLSTANSTVASLSTSTVASLNSLSTGLSTTNSNVASLSSSTSTGLSSANSAVASLSTSTSTGLSSANSNIGSLSTGLSTTNSTVASLSTSTVAGLNSLSTGLSTTNSNVASLSSSTSTGLSSANSAVASLSTSASTGLSSANSNIGSLSTGLSTTNSTVASLSSSTSTGIGSLSTGVANSVQYDSPAHTSITLGGASATSPVKITNLAAGANPSDAVNYEQLTSLSTSASTGLSSANSAITSLSTSTSTGIGSLSTGLSTTNSNVASLSTSASTGLSSANSAITSLSTSTSTGIGSLSTGLSTTNSNVASLSTSASTGLSSANSAITSLSTSTSTGIGSLSTGLSTTNSNVASLSTSASTGLSSANSAITSLSTSTSTGIGSLSTGLSTTNSNVASLSTSASTGLSSAISAITSLSTSTSTGIGSLSTGLSTTNSNVASLSTSASTGLSSANSAITSLSTSTSTGIGSLSTGLSTTNSNLSSLSTSSSTGLSTANSNISSLSTGLNSLSTAVNGGGTKYFHANSTQPDSQALGADSVAVGPAAIAAGASGIAIGNAANAAANGAVAIGQAAVAKGGLAVSIGVSNTASGDGAVAIGDPNVATGTGAVALGADNSANGQGAVALGNANIATGTGSLAFGNTSTAAAAGAVALGAGAIANNANDVALGSASVTAAANPVASALIAGQAYSLAGGAPASVVSVGAPGAERQITNVAAGRISATSTDAVNGSQMNAMTQALESLSTSTASALSTAQSGLGSLSTGLSSTQSSVSSLSTGLSTTSGNVASLSSGLGTMQSGIASLSTGLSTTNSSLASLSTAVSGGGVRTSSLGDTSAGNGANASGGNGTAVGGAASASGTDATALGQASNASGNHSTALGQASSASGSGSTAVGQGAGAPGDGASAFGQGALASGTDSTALGAHSTAAAPNSAAIGANSVASAPNSVSFGSRGHERRLTNVAPGIDGTDAANMNQLWGVQSSVDQAARRAYSGVAAATALTMIPEVDPGKTIAVGIGAGSYQGYSASAIGVSVRFSDNLKAKLGVGISAQGSTYGAGVSYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M76</accession>
    <name>Q63M76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter, periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004548376.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110795.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0786"/>
    <dbReference type="EnsemblBacteria" id="CAH38246">
        <property type="protein sequence ID" value="CAH38246"/>
        <property type="gene ID" value="BPSS0786"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0786"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7038"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAPQDTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266431" evidence="1">
        <location>
            <begin position="28"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="36"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="35726" checksum="CBB8FEA187F2F020" modified="2004-10-25" version="1">MTWINRGRALAGCVALAGALAAAPAGADTGKVGLDLPLLTSPFWQSYNRYLLHYAKDMQIDALAPVNSNGDPAQQITDMNTLLNLGAKGIVVGPLDSAAIGRALDAAAARNVPVVAVDVAPTQGKVAMVVRADNRAYGEKACQYLGEHVRRGKVVQIMGDLASVNGRDRSEAFRACMKGYPNLQVLEIPAAWKGDVAATALDSLLSANPDVKGIYLQAGGVYLSPTLQTLRRKQMLYPAGDAKHVAIVSNDGIPQEYEAIRRGDIDATVSQPADLYARYGLFYIKAALAGRTFKPGPTDHGSVIVQRAPGVLEDQLPAPLVTKANVDDKGLWGNTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA7</accession>
    <name>Q63MA7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110764.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0753"/>
    <dbReference type="EnsemblBacteria" id="CAH38213">
        <property type="protein sequence ID" value="CAH38213"/>
        <property type="gene ID" value="BPSS0753"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0753"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4818"/>
    <dbReference type="eggNOG" id="ENOG503179K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VSFCNVY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="106" mass="10965" checksum="C5200301DCAE30B4" modified="2004-10-25" version="1">MEGSSPGRAINPNPAESYSFITVEQDGNPLGENQMKSLQIAVVALSLSAVMATAHAQPAAADAGRQPANRTEAVQAAGRVPAAHQDRQDPNACVGPVSFCNIYFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MI6</accession>
    <name>Q63MI6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">treA</name>
        <name evidence="7" type="ordered locus">BPSS0671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205444.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110685.3">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0671"/>
    <dbReference type="EnsemblBacteria" id="CAH38130">
        <property type="protein sequence ID" value="CAH38130"/>
        <property type="gene ID" value="BPSS0671"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0671"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6878"/>
    <dbReference type="eggNOG" id="COG1626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TNGVLIW"/>
    <dbReference type="BRENDA" id="3.2.1.28">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01060">
        <property type="entry name" value="Peripl_trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023720">
        <property type="entry name" value="Trehalase_periplasmic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="565" mass="62054" checksum="A033693794D05E54" modified="2004-10-25" version="1">MVTPRHRPLHVENPFYRRLLNAPAWVALVAAAGIGCTSATLARADSSPAHASTAAAVASAASAPGAASIPPPPSQLYGDLFVAVQTAQIFADQKTFVDSTPNADPATIVQLYQQQKGQPGFSLKAFVAQYFTPPSDESVTPPPNQMLREHIDWLWPKLTRTTTTAPPYSSLIALPKPYVVPGGRFREGYYWDTYFTMLGLQEAGREDLVDNMLDNFAYLIDTVGHVPNGNRSYYVSRSQPPFFAYMVTLAAKAEGNRVYQKYLPALRKEYAYWMQGERTTPRGQATRNVVAMPDGSVLNRYWDASDTPRDESYLEDVKTAQQASGRPAAEVWRDLRAAAESGWDFSSRWFGDNRTLATIRTTAIVPVDLNSLMFNLETTIVKGCAVTRDFACVAEFAGRAGKRAVAINRYLWNRNGYYGDYDWKLGKPRDNLSAAALYPLFAGVAWPERAKQTAKNVQKALLKPGGLATTTYDTAQQWDAPNGWAPLHWIALVGLRHYGEKSLADDIGTRFLADVKGVYAAQGKLVEKYIVEGVGTGGGGGEYPLQDGFGWTNGVTLKLLDLYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ4</accession>
    <name>Q63MJ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554874.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110677.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38118">
        <property type="protein sequence ID" value="CAH38118"/>
        <property type="gene ID" value="BPSS0659"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0659"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4705"/>
    <dbReference type="eggNOG" id="ENOG5032X8H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFMRYQV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010694">
        <property type="entry name" value="Uncharacterised_VirK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06903">
        <property type="entry name" value="VirK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266993" evidence="1">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="15861" checksum="EF7BD0B5B5B00958" modified="2004-10-25" version="1">MVRKNSIVSSLVLSVAITSGTSFANANSSEGAFLESAVMAGKDIRVILDLSRCIEHGTQIPGPAVRGSVRPDTFMILSDHSIAFSNTHFTVPADNKPVQEFMKYRANGDGKVEFQTMVLDPINFSVLRKNQYDCEVNKGVKFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MN8</accession>
    <name>Q63MN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551438.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110633.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0612"/>
    <dbReference type="ESTHER" id="burps-q63mn8">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38069">
        <property type="protein sequence ID" value="CAH38069"/>
        <property type="gene ID" value="BPSS0612"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0612"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6795"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTEVPVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="596" mass="64766" checksum="D5BFB30F675179BD" modified="2004-10-25" version="1">MQPLSDEAPLALFESVHTETAVAAGDVTLAAKTWGDASRPAVVLVHGYPDNSEVWRRVAPLLAKSYYVIAYDVRGAGLSTKPARTADYRLERLVDDFAAVIDALAPNRAVHVVGHDWGSIQGWEFVTEPRLAGRILSYTSCSGPNLDHVGYWLRQQLARPSPASIKRLAGQLVRSWYVYLFHLPLIPELNWRLWLGRAWPALMRRLEHTDVGVRPTQTEDGVHGVRLYRANFLRRVLAPRERYAHAPVQVVVPLRDKFVSPALSADIARWVPTYYRREVAERHWLPMSEPARFAALAQELIEAVETGVQPPALAHARRRSGTGPFVGKRVVITGAGSGIGRCAAVEFAKQGASIVAVDIDEQAAERTALLVRLLGAQADVRRVDVGSADDMEALANWVGDELGGADVVVNNAGIGMAGGILDTSAAHWERILRVNLWGVIHGSRLFAKQMAARGAGGHIVNTASAAAFGPSRDLPAYATTKAAVLMLSECMRAELADHGIGVTAVCPGFAETGIMASTQYASAKSDQDEARLRKRATKLYQMRGLKPETVAKAMVDGVLQNQPVVAIGAEAHAMRFVGRFAPWLGRLIARVSMASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY8</accession>
    <name>Q63MY8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110531.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0510"/>
    <dbReference type="EnsemblBacteria" id="CAH37967">
        <property type="protein sequence ID" value="CAH37967"/>
        <property type="gene ID" value="BPSS0510"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0510"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4522"/>
    <dbReference type="eggNOG" id="COG1213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYSLWCA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="28557" checksum="50C01FB951602434" modified="2004-10-25" version="1">MRGELMRAIILAAGLGLRLQLPPEAQFPKCLLRFDDTSLLERHLRVLDAAGVDEIVLALGFQSEKVEAELARLNRRAEIVLNPRYDLGSVLTVHTAADALTRGGDVLLMDADVLYDEAILHALVADPSRAIDRLLIDRDFEAGDEPVKLCVKDGVPVELRKQLAAGLEYDTIGESVGFFRFSEGTARRLAEIVAGYVDGGRANMPHEEAVRDLLLEGGRTFDIADVTGSPWIEIDFPGDVARARDEVLPHIQQRTIGAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N82</accession>
    <name>Q63N82_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551340.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110437.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0414"/>
    <dbReference type="EnsemblBacteria" id="CAH37869">
        <property type="protein sequence ID" value="CAH37869"/>
        <property type="gene ID" value="BPSS0414"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0414"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6547"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGAMHLN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="201"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="394"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="570" mass="61973" checksum="AF3C1F21EFA83ACD" modified="2004-10-25" version="1">MKASNAIARFLAAHDVRHCFELVGGMITHLLDSFAESGRFQIVSMHHEQAAAFAAEGVARRYMGRKVAVALGTSGPGATNLITGIGSCWLDSVPCVFITGQVNTHELKGERAIRQQGFQELDIVPMVRSITKHAVQVSDANELLPALHGALSAALSGRQGPVLIDIPNDVQRAEIADAAVDRWLGEPLRIRDRCEPGDRDIDALRELCRSSSRPLVCFGGGARWAPSMPAWIAALEDARIPYVSTLMGHERVPAGAHYFNMIGAYGNREANWAVQHCDLLIVIGARLDVRQTGADVGDFARHARVIQIDIDPAQLNNRIKVEQALCCDAESFFRRFAVRRDTFAGIRPDWADQLATLRTAHARNEYPDWNISPGVVFARLNEAMAGKAVHYVCDVGNHQMWAAQGLRLGATQAVHYSGGMGAMGFALPTAIGIACSGDGGGKTVVITGDGSLQVNVQELDTLSRLQLDVAIVVMNNYSLGMVKNFQDMYFDGKNISTKQGYSCPSFVALARAYGIESMTVAAPAELQRAIDRVAGSRRPLLVEIAMPEATECRPRLAFGRKLDDQYPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NN0</accession>
    <name>Q63NN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysine-arginine-ornithine transport system, binding exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argT</name>
        <name evidence="7" type="ordered locus">BPSS0269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197330.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110289.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0269"/>
    <dbReference type="EnsemblBacteria" id="CAH37716">
        <property type="protein sequence ID" value="CAH37716"/>
        <property type="gene ID" value="BPSS0269"/>
    </dbReference>
    <dbReference type="GeneID" id="56597849"/>
    <dbReference type="KEGG" id="bps:BPSS0269"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6360"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GSIHERF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005768">
        <property type="entry name" value="Lys_Arg_Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01096">
        <property type="entry name" value="3A0103s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266196" evidence="5">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="28334" checksum="383481E6E739F2FD" modified="2004-10-25" version="1">MKKILAALTVALLAVSAGGVQAKDWSTIRFGVDASYPPFESKGPDGKVVGFDVDLGNEICKRVKAKCVWIENDFDGMIPALKARKFDGVLSSMSMTPQREEQIAFSSKLFNTPTRLVTKKGANLMPTAESLKGKTVGVEQGTIQETYAKVHWAPMGVKVQPYQNQDQVYADLIAGRLDAALQDAVQADIGFLKTPRGKDYAFAGTDLNDPKTLGEGAGIGLRKEDTDLKAKIDKAIADMHKDGTYDKIAKKYFDFDVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NQ7</accession>
    <name>Q63NQ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hemin ABC transport system-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551264.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110262.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0243"/>
    <dbReference type="EnsemblBacteria" id="CAH37689">
        <property type="protein sequence ID" value="CAH37689"/>
        <property type="gene ID" value="BPSS0243"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0243"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6329"/>
    <dbReference type="eggNOG" id="COG3720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTHEFFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007845">
        <property type="entry name" value="HemS/ChuX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05171">
        <property type="entry name" value="HemS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HemS" evidence="1">
        <location>
            <begin position="43"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HemS" evidence="1">
        <location>
            <begin position="221"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="383" mass="41466" checksum="32909BF0E7C108E2" modified="2004-10-25" version="1">MMNTAAPAASPARALAPDELRDAFLHLKETRKLRNRDVAQLLGVSEGEALAAFAGERVVRLESSFVELFEEMPRLGGVMALTRNAAAVHEKDGAFEQMSHDGPVGLAFGAIDLRIFYRNWAAGFAVYEPTAHGVMKSLQFFDAQGDAVHKVYLRKHSDHAAFDAFVSRWRMPVQSPAFAVEPAPPAHVERPDGEIDAAGLRAAWDAMTDTHQFHGVVRRHGVSRTQALRLAGASRAHRVATDAARRVLERAAQTRLPIMVFVGNRGMIQIHTGAVTNIRRMGTWINVLDEDFNLHLREDLVASAWVVRKPTSDGAVTSVELFDAAGDNIAMLFGARKPGQPELAGWRELAGALPRLDTADAADAATVAHAADVPVATDAGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NQ9</accession>
    <name>Q63NQ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative hemin ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529789.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110260.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0241"/>
    <dbReference type="EnsemblBacteria" id="CAH37687">
        <property type="protein sequence ID" value="CAH37687"/>
        <property type="gene ID" value="BPSS0241"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0241"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6326"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="373" mass="37559" checksum="AF358E4DF61868BC" modified="2004-10-25" version="1">MSLAARRHSARPISAERGSTCASRALAALRRRRARWTLAALIAALAAASIAALCIGAYRLSPAQLLGALTATDAQLAGDAALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRNPLADPGLIGVSSGAALGASALIVLGPLFAARLALGLLPVAAFAGALAVAALVYRLAIARGRLALPLLLLAGIAINALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFALAGCVLLARERHALNALQLGEAEAMHLGVPVPRVKRRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVMPGAALFGALLAVAADLAARTLAAPAEIPLGILTALIGAPFFLALLWKRRGALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NT0</accession>
    <name>Q63NT0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein MgtC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551250.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110239.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0219"/>
    <dbReference type="EnsemblBacteria" id="CAH37664">
        <property type="protein sequence ID" value="CAH37664"/>
        <property type="gene ID" value="BPSS0219"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0219"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6291"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMRTHTL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="231" mass="24533" checksum="84C8BD24DA30C195" modified="2004-10-25" version="1">MLNNVELIMRLMLAAALGSVIGIERERLSWAAGLRTHMLVCVGSALIMIVSAFGFADVLGQAHVDLDPSRMAAQVVSGIGFLGAGSILLRGEIVRGLTTAASLWSVAAVGLAVGGGLYAAAIAATIIILVILAGIKPLERRYLSVRQRRHLMLLVERGTLTFDSLHAALGLDSARVKRFIVQQSEDSADSDEVTIALGRVSDVEYESICARLRQLPGVKGFSERKGGLPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI2</accession>
    <name>Q63PI2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536471.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109987.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3394"/>
    <dbReference type="EnsemblBacteria" id="CAH37406">
        <property type="protein sequence ID" value="CAH37406"/>
        <property type="gene ID" value="BPSL3394"/>
    </dbReference>
    <dbReference type="GeneID" id="56527760"/>
    <dbReference type="KEGG" id="bps:BPSL3394"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1796"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEQYISV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="479"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="576" mass="62620" checksum="08D8F485E0EF1B9C" modified="2004-10-25" version="1">MAADSGMGALIAPMHGLSYVRGPADVPLSDATIGQFLLDTVARFPDRAAVVFREQGVRWTWREFADEVDALAAALIELGIARGDRVGIWSPNRAEWLLTQFATARIGAVLVNVNPAYRLAELEYALNKVGCKLLIAAERFKTSAYAEMIAEIAPELATTRAGDVLCAARVPSLRTVVTMSDAAHAGMLSFADVLARGRAALASARLDAIGATLDCRDPINIQFTSGTTGSPKGATLTHRNVVNNARSIANVMRLTEADAMCIPVPLYHCFGMVLSVLACVSAGAKMVFPGAAFEPGATLAAVSDERCTALQGVPTMFIAELDHPDFDRFDLSTLRTGIMAGSPCPIETMKRVVAKMHMSEVTIAYGMTETSPVSFQSATTDSLEKRTTTVGRIQPHLEAKIVDATGAIVPVGETGELCTRGYSVMLGYWDDEARTREAVVDGWMRTGDLATLDEEGFCNIVGRLKDMLIRGGENVYPREIEEFLFRHPKIQSVQVFGVPDSKYGEEVCAWIVLRAGETMTDDELREFCSGQIAHYKVPRYVRFVDELPMTVTGKVQKFVMRERMIDELGLSVQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PL3</accession>
    <name>Q63PL3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">BPSL3361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938975.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109956.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3361"/>
    <dbReference type="EnsemblBacteria" id="CAH37374">
        <property type="protein sequence ID" value="CAH37374"/>
        <property type="gene ID" value="BPSL3361"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3361"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1839"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="126" mass="13282" checksum="8B8CD6BF77B585D0" modified="2004-10-25" version="1">MSNVPAELKYTDEHEWIRTEADGTLTIGITDHAQTTLGDIVFLELPKVGSQVKAGDAIGVVESVKAASDIYSPVTGEVIAINTDVADAPEEVNGDAYGAWLFKIKLAADASTDCLLDAAAYEKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM3</accession>
    <name>Q63PM3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109946.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3350"/>
    <dbReference type="EnsemblBacteria" id="CAH37363">
        <property type="protein sequence ID" value="CAH37363"/>
        <property type="gene ID" value="BPSL3350"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3350"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3807"/>
    <dbReference type="OMA" id="ADDVPMH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="104" mass="10136" checksum="09CF8EB7DD24FAD7" modified="2004-10-25" version="1">MLCVALVGVVFGVRAAPGIDVVTCGPAPASLAAGAQVPCTLPDGSAGVQQVVHLTLVNDGATGDAPISGGIEAGMAVGSAVFLVLAIAFGMRALRRFVDSASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PV8</accession>
    <name>Q63PV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative plasmid conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938884.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109860.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3264"/>
    <dbReference type="EnsemblBacteria" id="CAH37277">
        <property type="protein sequence ID" value="CAH37277"/>
        <property type="gene ID" value="BPSL3264"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3264"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1959"/>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMERHAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040677">
        <property type="entry name" value="LPD7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18821">
        <property type="entry name" value="LPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD7" evidence="2">
        <location>
            <begin position="421"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="661" mass="73698" checksum="274CCCBAE610E47F" modified="2004-10-25" version="1">MIAKHVPMRSLGKSDFAGLVKYITADQAKEHRIGEVRLTNCAALTVRDAVTEVLATQQANTRAKSDKTYHLLVSFRAGELPDAATLEAIEARICAGLGFSDHQRVSAVHHDTDNLHVHIAINKIHPTRNTIHEPYYPHRTLAELCDVLERGYGLQRDNHAPRRRGAESRAVDMERHSGIESLVGWIKRECLEEIRGARSWAGLHQIARANGLEIRAKGNGLVIEASNGTQIKVSTLGRDFSKVKLEGRYGPFESLPVRRADVSSKRQYQKDPIPLRVNTVELYAKYQIAQQRATTDRAAALAELRSQKEKQIENAKRKGQTRRAAIKLLGGGRLTKKVLYAQASGALKSELQAIYTQHRVACQRLYEQHRRHTWADWLKQEALQGNAEALTALRAREAAQGLKGSTIKAEGRPQPGHAPVIDNITKTGTIIYRAGNSAVRDDGDRLQVSGQAGQESVQQALRLAVERYGDRITVAGSAEFKARVIRAAIDIRLPIMFDDPSMERLRQQYMTTRQPARVSRPAVKPVGSAPPPQARNRLRTLSQLEVPSIKGGDQAVSRHSVKKPIESDPARQQVEHAVQQAVSRFKAVANRRKVRANGYGDQGKAWQNLPGELRERIDRFNSQPPERQEIELARMRREVAERRGGESSSLAGATRQKGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q55</accession>
    <name>Q63Q55_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL3170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109763.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3170"/>
    <dbReference type="EnsemblBacteria" id="CAH37180">
        <property type="protein sequence ID" value="CAH37180"/>
        <property type="gene ID" value="BPSL3170"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3170"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3622"/>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QHTRREL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013355">
        <property type="entry name" value="Pilus_4_PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02515">
        <property type="entry name" value="IV_pilus_PilQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="8">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="442" mass="46957" checksum="FF0A01301BE1C4E8" modified="2004-10-25" version="1">MPLAPAQRMSDEHRSSPPAAGAVSTASVAGTGTETGDPSGDNRPISINLQQASLAAVFDAFARFTGLNIVVSERVRGTVSLRLNNVRWRSAFDALLDAHGLAMARRGSVIWVAPVAELAERERQRFDAHARAAQLEPLASRGFVLRYARAADVQRLLAGSAGQRILSKRGSVLADPRTNLLFVTDLSGRLAQIADLIGKLDTPSRQVLIEARIVEGDRGFSRNLGARLALRAPDAGERATGIVAGRNGTLAELAARPISGFDAATAGLTLFAARASRLLDVELSALEAEGRGQIVSSPRVVTADRTKAVVEQGAELPYQAKVGNGVSGVQFRRATLKLEVEPQITPDGRVILDLDVAKDSVGEETASGPAIHTKHVQTRVEVENGGTVSIGGIFESDDRDDVTRVPLLGKIPVLGALFRHRAQRAQRSELVVYITPTVVIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QC1</accession>
    <name>Q63QC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200010.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109697.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3102"/>
    <dbReference type="EnsemblBacteria" id="CAH37113">
        <property type="protein sequence ID" value="CAH37113"/>
        <property type="gene ID" value="BPSL3102"/>
    </dbReference>
    <dbReference type="GeneID" id="56594015"/>
    <dbReference type="KEGG" id="bps:BPSL3102"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2141"/>
    <dbReference type="eggNOG" id="COG3520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAFFDVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03347">
        <property type="entry name" value="VI_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="41028" checksum="81C9B613C3E8FB78" modified="2004-10-25" version="1">MQTAQRRIDPGVVERLLDEPHRFEFFQAVRLLETWFAKHDAPRHAASRPGEIVARRIGFRNTLSLGFPPSEIERAQSYDAAGAALKDDVRRNAALEAGALSRVELTPAFFGLLGGQGALPLHYTEQIIAREQLKRDHAAHAFFDVFSNRATALFYSAWKKYRLPLHYELDRDERYLPLLLALAGVSNDDARSTVQQGRGALLDEAIAGYALAARHRPVSAAYLQRTLSEYFRVPIRVEQFVGKWYDVPPDQLSVLGDVNVTLGATALVGERVWQRDMRARLVVGPLTKRDYEAFLPGEERAIALERMLTLLAGVTLEYEVSLVLRRAEVGASVLGAGARLGWDAFLCTREAGRDRADARYELHVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI3</accession>
    <name>Q63QI3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phenylacetic acid degradation enoyl-CoA hydratase PaaF</fullName>
            <ecNumber evidence="4">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">paaF</name>
        <name evidence="4" type="ordered locus">BPSL3040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109635.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3040"/>
    <dbReference type="EnsemblBacteria" id="CAH37051">
        <property type="protein sequence ID" value="CAH37051"/>
        <property type="gene ID" value="BPSL3040"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3040"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3471"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELSMSCD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="28703" checksum="B80CC21B14E3249A" modified="2004-10-25" version="1">MIEEKQMAYENILVETRGRVGLITLNRPKALNALNDALMDELGLALKAFDADEGIGAIVLTGSEKAFAAGADIGMMATYSYMDVFKGDYITRNWETVRQIRKPIIAAVAGFALGGGCELAMMCDIIFAADTAKFGQPEIKLGVLPGAGGTQRLPRAVSKAKAMDMCLTARFMDAEEAERAGLVSRILPADKLLDEAIAAATTIAEFSLPAVMMVKEAVNRAYETTLSEGVHFERRLFHSAFATEDQKEGMAAFVEKRKPVFKHR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM5</accession>
    <name>SYP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">BPSL2998</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194217.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109593.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QM5"/>
    <dbReference type="SMR" id="Q63QM5"/>
    <dbReference type="STRING" id="272560.BPSL2998"/>
    <dbReference type="EnsemblBacteria" id="CAH37009">
        <property type="protein sequence ID" value="CAH37009"/>
        <property type="gene ID" value="BPSL2998"/>
    </dbReference>
    <dbReference type="GeneID" id="56594251"/>
    <dbReference type="KEGG" id="bps:BPSL2998"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2272"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000248659" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="578" mass="63420" checksum="39680FDBB50D068F" modified="2004-10-25" version="1">MKASRFFIGTLKEAPADAEIVSHKLMVRAGMIRRVAGGIYNYLPVGLRSIRKVEAIVREEMNRAGAIELLMPAVQPAELWQESGRWEQYGPELLRFKDRKQNEFVIGPTHEEVVTDIARNQIKSYRQMPVNFYQIQTKFRDEIRPRFGVMRGREFIMKDAYSFDKDHESLKESYKKMYDAYVRIFTRIGLEFRPVAADNGSIGGSGSHEFHVIADTGEDAIAYCPTSDFAANVEAAEALPLLASRAAPAEAMQKVATPGKAKCEAVAELMGIPLERTIKSIVLATDNEGAEPTIWLLMLRGDHDLNEIKTAKLPGLAGHRFATEAEIVEWFGTPPGYLGPIGTKKPVRVVADRTVANMSDFVVGANEVDYHIAGVNWGRDLPEPVVADIRNVKAGDPSPDGKGALDICRGIEVGHVFQLGTKYSDAMGATFIDESGKAQPMVMGCYGIGITRILGAAIEQNFDDKGIVWPEAIAPFEVVLCPMGYDRSDAVREAADKLYADLAAAGIDVILDDRGERPGVMFADWELIGVPHRLVIGERGLKDGKIEYQGRRDAEATLLPADSAAAAVAEKVRAALAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QS9</accession>
    <name>ALLC2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable allantoicase 2</fullName>
            <ecNumber evidence="1">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Allantoate amidinohydrolase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alc2</name>
        <name type="ordered locus">BPSL2945</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531999.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109539.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QS9"/>
    <dbReference type="SMR" id="Q63QS9"/>
    <dbReference type="STRING" id="272560.BPSL2945"/>
    <dbReference type="EnsemblBacteria" id="CAH36955">
        <property type="protein sequence ID" value="CAH36955"/>
        <property type="gene ID" value="BPSL2945"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2945"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2335"/>
    <dbReference type="eggNOG" id="COG4266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTHIRIN"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0659">Purine metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205920" description="Probable allantoicase 2">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <sequence length="336" mass="36972" checksum="8433A0EEB794BD93" modified="2004-10-25" version="1">MAAPILDPNAPAFTRRYMNLADPRLGAKALFASDEFFAPKERMLDPEPAVFIPGKYDDHGKWMDGWETRRKRTTGHDFCVVRLARPGVVYGVDLDTSHFTGNFPPAASIDACVSDADTPPDDAVWETLVPATTLAGNQHHYVDVSNPRAYTHLRVNLYPDGGLARLRVYGQPQRDWSRAARGELVDLAAIENGAYLVAANNEHFGPASRMLMPGRGANMGDGWETRRRREPGNDWAIVALARPGVIRRVEVDTAHFKGNFPDRCSLQAARVAGGTDASLVTQAMFWPMLLGEQPLGMDSVHTFETQLAALGPVTHVRLNIHPDGGVSRLRLWGELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QY1</accession>
    <name>Q63QY1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ubiquinone biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527722.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109487.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2893"/>
    <dbReference type="EnsemblBacteria" id="CAH36903">
        <property type="protein sequence ID" value="CAH36903"/>
        <property type="gene ID" value="BPSL2893"/>
    </dbReference>
    <dbReference type="GeneID" id="56528304"/>
    <dbReference type="KEGG" id="bps:BPSL2893"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2397"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRWFARQ"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="8">
        <location>
            <begin position="12"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="397" mass="42205" checksum="C116351B3B36CF09" modified="2004-10-25" version="1">MTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSVALVDARDPDASENDPRAIAVSQGSRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVARYGSIVRALARAVRGTPARWLTSTSAHSPAQDADGVTIALDTPQGARTLRARVLVNAEGGLFDERKRKLTDSATNRDYGQTALVGTVTVSAPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPDVAQRRGALPDDAFLQELGATFGTRMGRFTRIVGRAAFPLGLAAAHTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTVDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF5</accession>
    <name>Q63RF5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550067.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109313.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2717"/>
    <dbReference type="EnsemblBacteria" id="CAH36725">
        <property type="protein sequence ID" value="CAH36725"/>
        <property type="gene ID" value="BPSL2717"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2717"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2612"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VACNVYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266537" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="122" mass="12061" checksum="8F9034DEF3F244F1" modified="2004-10-25" version="1">MKSIVSKAVAGMIVAALACGNAFAQASGAAAEASAPAAAQNASKAAAKTVRKSNRKLGYAVRKAISKVNGVNVSNITVRTKGGVVTLEGSVPDASQIDKAVEAAKGVAGVVSVNNKLSVQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RM5</accession>
    <name>Q63RM5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109243.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2647"/>
    <dbReference type="EnsemblBacteria" id="CAH36655">
        <property type="protein sequence ID" value="CAH36655"/>
        <property type="gene ID" value="BPSL2647"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2647"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3018"/>
    <dbReference type="eggNOG" id="ENOG50331CV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYGPQKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="11224" checksum="A546616040E59F3D" modified="2004-10-25" version="1">MLIKCRFPRTFAFDATMRTTQATRAVERLRARAGNPQYSAVGMPGGLFYLVDRSSGAAEKLCAPMPLEDFVAFVDGLGPKKPRKVSKLDVAFEQQIKNSKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RS4</accession>
    <name>MINC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">minC</name>
        <name type="ordered locus">BPSL2597</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522312.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109193.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RS4"/>
    <dbReference type="SMR" id="Q63RS4"/>
    <dbReference type="STRING" id="272560.BPSL2597"/>
    <dbReference type="EnsemblBacteria" id="CAH36605">
        <property type="protein sequence ID" value="CAH36605"/>
        <property type="gene ID" value="BPSL2597"/>
    </dbReference>
    <dbReference type="GeneID" id="56528603"/>
    <dbReference type="KEGG" id="bps:BPSL2597"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2760"/>
    <dbReference type="eggNOG" id="COG0850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RRDPLWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007874">
        <property type="entry name" value="MinC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05209">
        <property type="entry name" value="MinC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01222">
        <property type="entry name" value="minC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_1000047817" description="Probable septum site-determining protein MinC">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="270" mass="28931" checksum="2EA8F3FB4AAA3040" modified="2004-10-25" version="1">MSLKKSPFFELRSGSVDTLLFIVKTADLDALRAELVKRFEATPEFFADDVVAIDVRRLADHERVPLDDIRGMLNDVRMRAIGVVAQPEQHAWAASAGLPLLEARDRRAPSSKAADEAPVQQAEPAAPAAGQAALFEQAGPTLADAGAPPESPAPAVAAQSATLVVDRPLRSGQQIYAKGDLVVLGPVSYGAEVIAEGNIHIYAPLRGRALAGVHGNHDARIFCTCLEPELISIAGIYRTTENPLPADVLGKSVQIRLEQEKLMIEPLRLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX4</accession>
    <name>F16PA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="1">FBPase class 1</shortName>
            <ecNumber evidence="1">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbp</name>
        <name type="ordered locus">BPSL2547</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189384.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109143.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RX4"/>
    <dbReference type="SMR" id="Q63RX4"/>
    <dbReference type="STRING" id="272560.BPSL2547"/>
    <dbReference type="EnsemblBacteria" id="CAH36554">
        <property type="protein sequence ID" value="CAH36554"/>
        <property type="gene ID" value="BPSL2547"/>
    </dbReference>
    <dbReference type="GeneID" id="56596407"/>
    <dbReference type="KEGG" id="bps:BPSL2547"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2825"/>
    <dbReference type="eggNOG" id="COG0158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364499" description="Fructose-1,6-bisphosphatase class 1">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <sequence length="338" mass="37377" checksum="B4964A195E9A89F8" modified="2004-10-25" version="1">MSITRRTTLSKYLIEQQRETHNLPADLRLLIEVVARACKAISYNVSKGALGDALGTAGSENVQGEVQKKLDILSNEILLDANEWGGNLAAMASEEMETFFPIPANYPRGEYLLVFDPLDGSSNIDVNVSIGTIFSVLRCPDGQQATEQSFLQPGTEQVAAGYAVYGPQTVFVLTTGNGVNCFTLDREVGSWVLTQSNLRIPEDTREYAINASNARHWYEPVKRYIDELNAGAEGPRGENFNMRWIASMVADVHRILNRGGIFMYPADKRTPDRPGKLRLMYEANPMSFIVEQAGGAATTGLKRILDVQPTGLHQRVPVILGSKNEVERVARYHEQAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ6</accession>
    <name>Q63RZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109121.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2525"/>
    <dbReference type="EnsemblBacteria" id="CAH36532">
        <property type="protein sequence ID" value="CAH36532"/>
        <property type="gene ID" value="BPSL2525"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2525"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2876"/>
    <dbReference type="eggNOG" id="COG3963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIWMNLP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="228" mass="24247" checksum="9FFAC2B438AF620B" modified="2004-10-25" version="1">MPGTACRSIPQERNMRIHELALFLRAWLRNPRQVGALAPSGPALAALMTAQIPGESARVIELGAGTGVFTRELLSRGVAADRLVLVEADPAFAATLRRRFPALRVMNIDAAELGITHGLFGDARASTVVSGLPLVAMPVEQAIAIVHGAFAMHLGPGGAFYQFTYLPRCPIPVRRLAAIGIRAERIGIAWANMPPAAVYRLQRCADFSGSPSSLGRPWPSARPPSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SH1</accession>
    <name>Q63SH1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative alkane monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL2350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538099.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108945.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2350"/>
    <dbReference type="EnsemblBacteria" id="CAH36353">
        <property type="protein sequence ID" value="CAH36353"/>
        <property type="gene ID" value="BPSL2350"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2350"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3063"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHWSNDV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="115"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="43539" checksum="FC7B2B1B2FA05EED" modified="2004-10-25" version="1">MAIQQPVSADWTDTKRYWWLLGALTITLPLVAALLALSTGWHVFWWFGPLFAFGVIPVLDLLIGVDSENPPESIVPRLESERYYRYVVYLATFVVYVAFAGAIWIVATQPLAWYDYLGFAFSLGAATGISINTAHELGHKTSPLERWLAKITLAPVAYGHFFVEHNRGHHVRVATPDDPASARYGESFWAFLPRTVTGSIASAWRLEKARLARSGRSAWSWRNEVLQAWAMTVALWSAAIAFGGAKVVPFLLIQAAYGASLLEVVNYVEHYGLGRRQLPTGRYERCTPQHSWNSNHVVTNLFLYQLQRHADHHANPTRSYQALRHFDDSPQLPAGYAAMILLAYVPPLWFRVMNPRVVAHYGADMAQSNIKPSIRQKVLAELAIANAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SJ3</accession>
    <name>Q63SJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108923.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2327"/>
    <dbReference type="EnsemblBacteria" id="CAH36330">
        <property type="protein sequence ID" value="CAH36330"/>
        <property type="gene ID" value="BPSL2327"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2327"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2642"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYTSAAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="447" mass="47116" checksum="C27F12106363715A" modified="2004-10-25" version="1">METTMTFQHDERAERAPVGQPARAALAAFVGTTIEWYDFYLYATASALIFGKLFFPSGDPFFSTLASFGTFAVGFFARPFGGLVFGHLGDRVGRKKALVATLVIMAVGTVGIGLLPTYAQAGAVAPVALVVLRIAQGIAIGGEWGGAVLMASEHASADRRTFVASFAQLGSPAGLILALLAFRLVAGIEHDAFLAWGWRLPFLASAALLVVGLAIRAGVDESPEFARMKAQRRTAALPVADVVRDAWRTLLLCLGANVIGVAGAWFVNTFMLNYTTQTLGLDRALILDCLFVVAFIQLGTQLASGWFAQRIGTGRFLTAAAALAIASPYPMFALVSTGRPVAIVVGIAIAVMCMSSSYAVMAGFMSTAFDVRVRYSAISLSYQLCAALAGGLTPLAGTLLAHRFAGQWWPLAAFYSALAVVSLACIATLERGKRVGVGERRGALAKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SQ0</accession>
    <name>ENO_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">BPSL2270</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192585.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108866.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SQ0"/>
    <dbReference type="SMR" id="Q63SQ0"/>
    <dbReference type="STRING" id="272560.BPSL2270"/>
    <dbReference type="EnsemblBacteria" id="CAH36273">
        <property type="protein sequence ID" value="CAH36273"/>
        <property type="gene ID" value="BPSL2270"/>
    </dbReference>
    <dbReference type="GeneID" id="56596064"/>
    <dbReference type="KEGG" id="bps:BPSL2270"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3160"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000133859" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="427" mass="45683" checksum="37F3B901EEABF5B0" modified="2004-10-25" version="1">MSAIVDIIGREILDSRGNPTVECDVLLESGTMGRAAVPSGASTGSREAIELRDGEAGRYGGKGVLKAVEHINTEISEAIMGLDASEQAFLDKTLLELDGTDNKSRLGANAMLAVSMAVAKAAAEEAGLPLYRYFGGSGAMQLPVPMMNIVNGGAHANNSLDIQEFMIVPVSQPTFREALRCGAEVFHALKKILGDRGMSTAVGDEGGFAPNFGSNDECLSTILQAIEKAGYRAGEDVLLALDCAASEFYHDGKYQLAGEGLQLSSAEFTDYLATLADKFPIVSIEDGMHEGDWDGWKLLTERLGKKVQLVGDDLFVTNTRILKEGIEKGIANSILIKINQIGTLTETFAAIEMAKRARYTAVISHRSGETEDSTIADIAVGLNAGQIKTGSLSRSDRISKYNQLLRIEEDLGDIASYPGKSAFYNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SQ4</accession>
    <name>Q63SQ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524734.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108862.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2266"/>
    <dbReference type="EnsemblBacteria" id="CAH36269">
        <property type="protein sequence ID" value="CAH36269"/>
        <property type="gene ID" value="BPSL2266"/>
    </dbReference>
    <dbReference type="GeneID" id="56528923"/>
    <dbReference type="KEGG" id="bps:BPSL2266"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3164"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="174" mass="18323" checksum="2A00FA93B91893E8" modified="2004-10-25" version="1">MTIYKLGENAPSIHESVFVADSATIVGKVVLEENASVWFGATIRGDNEPITVGAGSNVQEGAVLHTDPGCPLTIAPNVTVGHQAMLHGCTIGEGSLIGIQAVILNRAVIGRNCLVGAGAVITEGKAFPDNSLILGAPAKVVRTLSDEDIARMHMNTKSYAMRRAYFKEQLVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV1</accession>
    <name>Q63SV1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205146.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108815.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2220"/>
    <dbReference type="EnsemblBacteria" id="CAH36222">
        <property type="protein sequence ID" value="CAH36222"/>
        <property type="gene ID" value="BPSL2220"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2220"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3225"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EEMFYLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="375" mass="41691" checksum="0A4FD50961043F0F" modified="2004-10-25" version="1">MELKKRSDGVDLLRGIAILLVLILHFHLTYRLHVLPFDVPWLSGAIKAISRNGNYGVTMFFAVSGFLITSTSARRFGSLGAIRPATFYRFRASRILPCLVLVLAVIVALGSLGMRSFVNKPDTASVLVSVLSVLTFWHNVLMAKVGYFNYSMNILWSLSVEEVFYLSFPILCLLLKRRRYILLFLCVPILVAPVYRSLHADDEIVALYGYLSCFDAIAMGACAALLPARAISRGRSRAIQWIAGLAIAVTYLSGPIMQHVVWGVSVVAFSTAALLYCFRGGAPAEAAAPSFVSRFIGWFGQRSYELYLFHIVVLGVLREYVTRENVDIAAKPLWLLFYLCVSALVAQFVFKYYSEPLNAALRRGATRPSAGYLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SY9</accession>
    <name>Q63SY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547886.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108777.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2182"/>
    <dbReference type="EnsemblBacteria" id="CAH36184">
        <property type="protein sequence ID" value="CAH36184"/>
        <property type="gene ID" value="BPSL2182"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2182"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3268"/>
    <dbReference type="eggNOG" id="COG3782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPGCHDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015003">
        <property type="entry name" value="DUF1853"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08907">
        <property type="entry name" value="DUF1853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="326" mass="34869" checksum="7706E0C6309D01EE" modified="2004-10-25" version="1">MSAAASPVPPVALRDAAVRDLAWLLSSASLLAPSAGAPLAQPWASVADAARTAAWLAALDAQPAPLHDALAHARPVRLGRYAECLLGFFVGHAPSLRLVAANLPLRSNGRTLGECDFLIETARGERLHWELAVKCYLCVATAGTASLADFVGPNLADRFDLKRAKLVDHQLRLTARDEFASLGHAGPWRAQMFVKGWLFYRADDGANAAGAVADPPEIGADHPRGFWITREAWPKFALAAARRDVAWIVLPRLAWLAPRAFDDADVACGRCVPLASDAVIDEVARQSGPLLVAALARDASGGWRETARGFIAPDDWPRRASAFAAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SZ9</accession>
    <name>PRMB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3 glutamine methyltransferase</fullName>
            <shortName evidence="1">L3 MTase</shortName>
            <ecNumber evidence="1">2.1.1.298</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N5-glutamine methyltransferase PrmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmB</name>
        <name type="ordered locus">BPSL2172</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:45020"/>
            <dbReference type="Rhea" id="RHEA-COMP:11063"/>
            <dbReference type="Rhea" id="RHEA-COMP:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.298"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.298" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192731.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108767.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SZ9"/>
    <dbReference type="SMR" id="Q63SZ9"/>
    <dbReference type="STRING" id="272560.BPSL2172"/>
    <dbReference type="EnsemblBacteria" id="CAH36174">
        <property type="protein sequence ID" value="CAH36174"/>
        <property type="gene ID" value="BPSL2172"/>
    </dbReference>
    <dbReference type="GeneID" id="56595956"/>
    <dbReference type="KEGG" id="bps:BPSL2172"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3278"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYYGHGT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02125">
        <property type="entry name" value="L3_methyltr_PrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017127">
        <property type="entry name" value="Ribosome_L3_Gln-N5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037167">
        <property type="entry name" value="Mtase_YfcB_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03533">
        <property type="entry name" value="L3_gln_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000414178" description="50S ribosomal protein L3 glutamine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02125"/>
        </source>
    </evidence>
    <sequence length="307" mass="33508" checksum="C05E7C949A479586" modified="2004-10-25" version="1">MTTSPTPFKTVRDLVRHAVSRFSQAKLAFGHGSDNAFDEAVYLVLHTLHLPLDTLEPFLDARLAPDEIDAVLAVIERRATERVPAAYLTREAWMHGHRFYVDERVIVPRSFIGELLDDGLQPYVEDPELVGSVLELCTGSGCLAILAALAFPNASVDAVDLSADALAVAKINRDNYGLDERIALYHGDLYAPLPQFKWIDPAQRYDVIIANPPYVNAGSMAELPAEYRHEPEMALAGGADGMDIVRRIIGEARRWLQDDGVLVVEIGNERANVEAAFGGLELVWLPTSAGDGSVFLIHASELPAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T47</accession>
    <name>Q63T47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muramoyl-tetrapeptide carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191814.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108719.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2122"/>
    <dbReference type="MEROPS" id="S66.002"/>
    <dbReference type="EnsemblBacteria" id="CAH36125">
        <property type="protein sequence ID" value="CAH36125"/>
        <property type="gene ID" value="BPSL2122"/>
    </dbReference>
    <dbReference type="GeneID" id="56595907"/>
    <dbReference type="KEGG" id="bps:BPSL2122"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3344"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="178"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="34306" checksum="D7A7A5FC41E9E76A" modified="2004-10-25" version="1">MISTPCTPRTIRLLAPSGYPHDPAAIERALERLSDEQHRIQNLDATQRRYQRFAGTDGERAGDLNRLADPSLPLPDIGLAVRGGYGAARILHGLDYRGLERRLRDQPIALVGHSDFTAIQLALYAKARVKTFGGPMLSADFGAPTPSEFTLAHFWQTLTQPTTTIVSDVPQTQVVNASGTLWGGNLAILASLVGTPYMPQIEGGILFVEDVNEQPFRIERMIYQLHLAGILARQQALVLGQFTGARPFDYDNGYDMQAMIEQVRGVIGIPIVTGLQFGHVPDLLTLPFGARAELVANEHGFRLTMSDYPHLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T84</accession>
    <name>Q63T84_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205124.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108682.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36084">
        <property type="protein sequence ID" value="CAH36084"/>
        <property type="gene ID" value="BPSL2083"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2083"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.84"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRHTGEP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="486" mass="52711" checksum="9B4484BDEA55554F" modified="2004-10-25" version="1">MVETLAGLFDFEMDPQSGVALTRQLRDQLRRAIAAGSLASGRRLPSSRALALHLRVSRNTVCAAIEQLAMEGYLDVSRGRRPVVAPMPSAGLVAIGSDRPVSDGRSGMSQWAQRIDRSDWPFISEGRPTPFAPCVADARAFPHAIWGRCLRTATRYAVARTSTACNRPGLRRALLHHLVEYRGVNADAHQVFLMPTAQAAIALVARVLLDPGDLAWVESPGYGGARAAFEAAGATVQGIALDQSGMAFETSTDTPRLIFVTPAHQHPTGLLMPPARRQALLRFAARVGARIIEDDYDSEFHYEGRPVAALQGADNADSVFYVGTFSKSLHADIRVGYVVVPGHFVDVFAKAQRHTGQIVGATLQDALAEFIDDGHYAAHIRKTTRLYHARRDYLCDALKAVGSELTVSPPDGGMQVVARLGPLRDDREICRRLAEAGVTARPLSPHYCAQTGAQGLFLGFAAWNECEIDAGVRILARVIREPKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TD2</accession>
    <name>Q63TD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108634.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36036">
        <property type="protein sequence ID" value="CAH36036"/>
        <property type="gene ID" value="BPSL2037"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2037"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="59" mass="6125" checksum="0CFC409EA5ED9A39" modified="2004-10-25" version="1">MHGKGRRRCDATDVTLVMIENPPSILATVRADNPGGIATTVAPLVGDAMAQWIGAPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TP4</accession>
    <name>Q63TP4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555916.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108522.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1922"/>
    <dbReference type="EnsemblBacteria" id="CAH35922">
        <property type="protein sequence ID" value="CAH35922"/>
        <property type="gene ID" value="BPSL1922"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1922"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4066"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERDWIRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="455" mass="47755" checksum="BB3359A626D9707A" modified="2004-10-25" version="1">MNTQEAKIVLETALICAQEPLKLGDLRKLFADGVSADTVRTLLEDLKQEWTGRGVELVALASGWRFQSKPAMRTYLDRLHPEKPPKYSRAVLETLAIIAYRQPVTRGDIEEIRGVTVNTQVVKQLEDRGWIEVIGHRDVPGRPALYATTKQFLDDLGLKALDDLPALEEPAAHLEASLLAQQAIDFPDDARGDGEAPAVAPETDAAAAQAGEVAEPASDSVVLRNEDTARADEPRQADAAPTRADEPRQEGATDGLAARIGDPADNDAGRADVDVDAAPALGEADAPRGGDTSGHAAREIDSREMTEPADAGGEAAGTTASHTHAVAPYHDAQSAADAVAAPHAGDAAADGERAESPSGTNENANYVAQPDAEPADAAHTATREAAADPVAGRATKEDHGAIGGIPHDAEPVRAHAEEALDDTSDSLADAVRSASEAAPEHERQDDEDAPAKRRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX3</accession>
    <name>NODI_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nod factor export ATP-binding protein I</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nodulation ATP-binding protein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nodI</name>
        <name type="ordered locus">BPSL1844</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (NodI) and two transmembrane proteins (NodJ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Lipooligosaccharide exporter (TC 3.A.1.102) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH35843" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35843.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538328.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108443.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TX3"/>
    <dbReference type="SMR" id="Q63TX3"/>
    <dbReference type="STRING" id="272560.BPSL1844"/>
    <dbReference type="EnsemblBacteria" id="CAH35843">
        <property type="protein sequence ID" value="CAH35843"/>
        <property type="gene ID" value="BPSL1844"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1844"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3973"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GETVFFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005978">
        <property type="entry name" value="ABC_transptNodI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01288">
        <property type="entry name" value="nodI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51240">
        <property type="entry name" value="NODI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0536">Nodulation</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000272597" description="Nod factor export ATP-binding protein I">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="304" mass="33863" checksum="5FA052AA942E3B6A" modified="2007-01-23" version="2">MSVAPIDFQQVEKRYDDKLVVDGLSFHVQPGECFGLLGPNGAGKTTTLKMLLGITHPDAGSISLCGEPVPSRARHARQRVGVVPQFDNLDPDFTVRENLLVFARYFGLTAHAARALVPPLLEFAKLESKADAKVGELSGGMKRRLTLARALVNDPDVLVLDEPTTGLDPQARHLMWERLRSLLARGKTILLTTHFMEEAERLCHRLCVIEEGRKIAEGAPRMLIEAEIGCDVIEIYGPDPVQLRDELAPFAERTEISGETLFCYVDNPEPIHARLKGRTGLRYLHRPANLEDVFLRLTGREMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TY0</accession>
    <name>Q63TY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW</name>
        <name evidence="11" type="ordered locus">BPSL1837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108436.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1837"/>
    <dbReference type="EnsemblBacteria" id="CAH35836">
        <property type="protein sequence ID" value="CAH35836"/>
        <property type="gene ID" value="BPSL1837"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1837"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2069"/>
    <dbReference type="eggNOG" id="COG4208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NEYNFVA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="55"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="292" mass="31205" checksum="C9E103C52E812B64" modified="2004-10-25" version="1">MSEPRAVRWLLTGAALAFLALFLVVPLAAVFFEALRKGVDFYLESLADPDAWSAIKLTLVVAAIAVPLNLVFGVCASWAIAKFEFKGKAVLTTLIDLPFSVSPVISGLVYVLLFGAQGWLGPWLQAHDVQIIFAVPGIVLATIFVTFPFVARELIPLMQAQGADEEEAARVLGASGWQIFRRVTLPNVKWGLLYGVILCNARAMGEFGAVSVVSGHIRGQTDTMPLHVEILYNEYNFAAAFAVASVLALLALVTLALKLFAERRLSAELAHGRDDASAAAAHPGAAVTSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UQ3</accession>
    <name>Q63UQ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSL1543</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193217.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108163.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1543"/>
    <dbReference type="EnsemblBacteria" id="CAH35544">
        <property type="protein sequence ID" value="CAH35544"/>
        <property type="gene ID" value="BPSL1543"/>
    </dbReference>
    <dbReference type="GeneID" id="56595716"/>
    <dbReference type="KEGG" id="bps:BPSL1543"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3585"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CINEPDL"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025138">
        <property type="entry name" value="DUF4072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13284">
        <property type="entry name" value="DUF4072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="DUF4072" evidence="15">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="29769" checksum="2B957DE7F5042374" modified="2004-10-25" version="1">MTTNLVVQSTAPLSDAHHKPLAALAHGARVVALDAQSIRIERANPAQRADIDAYCGTHALDYAFVDAARKLADFGLVAMDMDSTLITIECIDEIADFCGLKAEVSAITEAAMRGEIKDFNESLTRRVALLAGLEASALERVYEERLRLSPGAESMLAGVKAAGLKTLLVSGGFTFFTERLKARLGLDFAHSNTLEIVDGKLTGKVVGEIVNADVKARAVRETCAALGIEPARAIVIGDGSNDLKMMAAGGFSIAFRAKPIVRSAASAAFDHVGLDGLLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UU2</accession>
    <name>Q63UU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subfamily M23B unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108124.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1504"/>
    <dbReference type="EnsemblBacteria" id="CAH35505">
        <property type="protein sequence ID" value="CAH35505"/>
        <property type="gene ID" value="BPSL1504"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1504"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3540"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTWPANG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266355" evidence="1">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="30708" checksum="93CF7E4D478A9DAC" modified="2004-10-25" version="1">MSMLRAMQNNRSKVPLSLAQRAICMAAFALLGACATRLDQAPVVDRSGSLGTTAATQPPAPLPPAPPGYYRVKPGDTLYRIALENGQNYRDIAAWNNLTNPNQIEVDQLLRVSPTAGGATAAAPAAGAVVTPPLSSGPSNGAAAVPPIYGSGSTASAAPSAPAASASSEPSAPAANGNVSFAWPVRGALLNTFDDSKNKGINIGGPAGEAVKAAADGRVVYAGNGLRGYGNLIIIKHDATYLTAYAHNRALMVKEGDAVTKGQKIAEMGNSDSDRVMLHFEVRRQGKPVDPLKYLPPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UY4</accession>
    <name>RS18_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">BPSL1460</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193360.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108082.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UY4"/>
    <dbReference type="SMR" id="Q63UY4"/>
    <dbReference type="STRING" id="272560.BPSL1460"/>
    <dbReference type="EnsemblBacteria" id="CAH35462">
        <property type="protein sequence ID" value="CAH35462"/>
        <property type="gene ID" value="BPSL1460"/>
    </dbReference>
    <dbReference type="GeneID" id="46326395"/>
    <dbReference type="GeneID" id="60549327"/>
    <dbReference type="GeneID" id="61193899"/>
    <dbReference type="GeneID" id="66547338"/>
    <dbReference type="KEGG" id="bps:BPSL1460"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3489"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="PRO" id="PR:Q63UY4"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000111134" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <sequence length="91" mass="10613" checksum="054F933C59EC8A11" modified="2004-10-25" version="1">MARPTGKKFDKRRQQQNPLFKRKKFCRFTAAGVEQIDYKDTETLKDFIGENGKITPARLTGTKAHYQRQLDTAIKRARFLALLPYTDQHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V14</accession>
    <name>Q63V14_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531405.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108052.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1430"/>
    <dbReference type="EnsemblBacteria" id="CAH35432">
        <property type="protein sequence ID" value="CAH35432"/>
        <property type="gene ID" value="BPSL1430"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1430"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3451"/>
    <dbReference type="eggNOG" id="COG2130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYSGWQE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="18"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35202" checksum="92B098CFDDDCC923" modified="2004-10-25" version="1">MSQVNRRVLLVSRPEREARVENFELVETPLAPLAVGEVRVRNHFLSIDPYMRGRMNAGRSYAEPQPLGEVMGGGTAGEVVESRNPAFAPGDRVIGAYGWQEYGTSTGKELRKVDTTRVPLSAYLGAAGMPGVTAWYGLNRIIRPRAGETLVVSAASGAVGSVVGQLAKLAGCRAVGIAGGADKCRYVVDTLGFDACVDYKAGRLADDLAAAAPDGVDGCFENVGGAVLDATLARMNPFGRIAMCGMIAAYDGAPAPLANPALILRERLLVQGFIVSEHFDVWPEALAQLASLVANRQLHYRETIAQGLERAPDALLGLLKGRNFGKQLVALV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V23</accession>
    <name>MSRB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="1">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrB</name>
        <name type="ordered locus">BPSL1421</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193880.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108043.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V23"/>
    <dbReference type="SMR" id="Q63V23"/>
    <dbReference type="STRING" id="272560.BPSL1421"/>
    <dbReference type="EnsemblBacteria" id="CAH35423">
        <property type="protein sequence ID" value="CAH35423"/>
        <property type="gene ID" value="BPSL1421"/>
    </dbReference>
    <dbReference type="GeneID" id="56595843"/>
    <dbReference type="KEGG" id="bps:BPSL1421"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3440"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000145360" description="Peptide methionine sulfoxide reductase MsrB">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01126"/>
        </source>
    </evidence>
    <sequence length="143" mass="16171" checksum="F964BD77806AE7C2" modified="2004-10-25" version="1">MSGDRDDPRYPYPKDDAELRRRLTPMQYEVTQHAATEPPFTGEYTDTEDAGIYHCVVCGTALFESGAKFHSGCGWPSYFKPIDGEVIDEKMDYTHGMTRVEVRCNQCGAHLGHVFEDGPRDKTGLRYCINSAALNFEAKPERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V44</accession>
    <name>Q63V44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192378.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108022.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1400"/>
    <dbReference type="EnsemblBacteria" id="CAH35401">
        <property type="protein sequence ID" value="CAH35401"/>
        <property type="gene ID" value="BPSL1400"/>
    </dbReference>
    <dbReference type="GeneID" id="56595866"/>
    <dbReference type="KEGG" id="bps:BPSL1400"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3410"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QCTRTHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="149" mass="16379" checksum="87B6776935CAA14B" modified="2004-10-25" version="1">MARSKVGLDQFMTYRMHVLNKLSDRGIGELYRMKLGISLPEARIIASVGAFGPFSIMELARRANLDKSQASRAAEALIRRGLVKRGPSDDDGRVVLIALTPAGAALNRKIMPIARKWNETLLDGLSESEKAAFSRALDKIIAGARERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V71</accession>
    <name>Q63V71_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107995.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1370"/>
    <dbReference type="EnsemblBacteria" id="CAH35368">
        <property type="protein sequence ID" value="CAH35368"/>
        <property type="gene ID" value="BPSL1370"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1370"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1537"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRDDPKC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="221" mass="23781" checksum="DAAF940DA73B4CC9" modified="2004-10-25" version="1">MRSPDSLAITDDDGRSHPAIFAPSTNNDKEDAMASPVAHKIMIVRHAEKPAGDGAPYGVNAKGEQDVEALTVFGWQRAGALAVLFAPSRGPLQHAELATPDWLFAAAVAKHAKSERPIDTITPLAHKLGLAIGDAYTKGQEKDLAQAAVASKGCVLIAWQHEDIPAIADALPLGKQTVPQKWPDDRFDIVWVFDLDTGSGTYRFSQVPQMLLKGDRNSVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VI3</accession>
    <name>Q63VI3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDOD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521883.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107883.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1262"/>
    <dbReference type="EnsemblBacteria" id="CAH35256">
        <property type="protein sequence ID" value="CAH35256"/>
        <property type="gene ID" value="BPSL1262"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1262"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.256"/>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWTKRIS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="484" mass="53094" checksum="FE6FFB63E716FC8D" modified="2004-10-25" version="1">MPITAQLPRTALLDKLWARMNERGDFPLLSDALRATMAAMKNDELDFTALVRVVLSDFALTQKVLRLANSAMYMAFGGNITTVTRALMVLGMDAVGHLVVGLKLVDHFHHSAPRRIDAKLELNRALLSGCVARKLTEHVDLRAGEQAVVCTLMRQVGKLLVVCYLDAEWEEIRRRAAEHDDDEAACRAVLGVGYDEIGLEAASRWRLPELIRAGMTRFDANDGAPHEVQWLRAVSHCSTDVATALTSTHAQQRDARIAALAHRFHGVLGTDADELADIAASLSREETSDTVMREIVELRANADKIARGASTPQACLEAGLADLRALPSEHVLGPVLALASESVLAGLAFTRTVMFVRHDDGVFAARLGFGPNVDAALERLRFHETFEPDVFHLAITNSVGIFIEHARDPKMTKRLPAWYLDAFDDARAFVLLPVIAERNAVALLYGDWALGQPARKITPQEMGVLNELAAELGRFFCGAQGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VM0</accession>
    <name>Q63VM0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoN</name>
        <name evidence="8" type="ordered locus">BPSL1224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201477.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107846.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1224"/>
    <dbReference type="EnsemblBacteria" id="CAH35219">
        <property type="protein sequence ID" value="CAH35219"/>
        <property type="gene ID" value="BPSL1224"/>
    </dbReference>
    <dbReference type="GeneID" id="56595158"/>
    <dbReference type="KEGG" id="bps:BPSL1224"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.302"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FYIRVIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="490" mass="52569" checksum="B2BDE14243199358" modified="2004-10-25" version="1">MQNAPMNVLLPDALVMAAIIVAWLNDTFVGAAGRRLTYLIAVVASAAAGVWFALQALDPQQYYFFSRMVVVDSFASAMKAVVSIGFAVTLVYSRKYLEDRDLFRGDVFLLGMFSLLGQLVMISGNHFLTLYLGLELMSLSLYAVIALRRDAAQSSEAAMKYYVLGALASGFVLYGISMLYGATGSLELNEVLKAVASGRINDAVLLFGVIFIVAGVAFKLGAVPFHMWVPDVYQGAPTAMTLFVGGGPKVAAFAWGLRFLVMGLLPLAVDWQEMLVILAALSLIVGNLTGIVQRNIKRMLAYSAISNMGFVLLGLLAGIVNGNPSAAASAYSSAMFYTIVYLVTTLGSFGVVMLLARRDFEAETLDDFKGLNKRSPVFAFVMMVMMFSLAGIPPTVGFYAKLAVLEATVNAGLTWLAVLAVVTSLFGAFYYLRIVKLMYFDAPQDTTPIAGDACKRAILVLNGLAVVVLGIVPGPLMTICLQAISHTLPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VS8</accession>
    <name>UPP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp</name>
        <name type="ordered locus">BPSL1166</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2008-07" db="PDB data bank">
            <title>2.6 A crystal structure of uracil phosphoribosyltransferase from Burkholderia pseudomallei.</title>
            <authorList>
                <consortium name="Seattle structural genomics center for infectious disease (SSGCID)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186446.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107788.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3DMP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A/B/C/D=1-216"/>
    </dbReference>
    <dbReference type="PDBsum" id="3DMP"/>
    <dbReference type="AlphaFoldDB" id="Q63VS8"/>
    <dbReference type="SMR" id="Q63VS8"/>
    <dbReference type="STRING" id="272560.BPSL1166"/>
    <dbReference type="EnsemblBacteria" id="CAH35161">
        <property type="protein sequence ID" value="CAH35161"/>
        <property type="gene ID" value="BPSL1166"/>
    </dbReference>
    <dbReference type="GeneID" id="56595096"/>
    <dbReference type="KEGG" id="bps:BPSL1166"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.371"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q63VS8"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120809" description="Uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="56"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="67"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="78"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
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            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="184"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="207"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="3DMP"/>
        </source>
    </evidence>
    <sequence length="216" mass="24075" checksum="DA8F1B3A2ECFB56B" modified="2004-10-25" version="1">MKQDSRFPNLFILDHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPITTKRVETPLVEIDAPVIAGKKLAIVPVLRAGVGMSDGLLELIPSARVGHIGVYRADDHRPVEYLVRLPDLEDRIFILCDPMVATGYSAAHAIDVLKRRGVPGERLMFLALVAAPEGVQVFQDAHPDVKLYVASLDSHLDDHAYIVPGLGDAGDRLFGTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VT9</accession>
    <name>Q63VT9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936879.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107777.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1155"/>
    <dbReference type="EnsemblBacteria" id="CAH35150">
        <property type="protein sequence ID" value="CAH35150"/>
        <property type="gene ID" value="BPSL1155"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1155"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.383"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SARWNVG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="76" mass="8019" checksum="D8356E959607BADE" modified="2004-10-25" version="1">MSQTASAPLSKALVSFDSLPNSAHVDVRTVAGLYGCSVPTVWRRVAAGLIPAAKKFGHSSRWNVGELRTNLVPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX3</accession>
    <name>Q63VX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase (LPS biosynthesis-related)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107743.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1122"/>
    <dbReference type="EnsemblBacteria" id="CAH35115">
        <property type="protein sequence ID" value="CAH35115"/>
        <property type="gene ID" value="BPSL1122"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1122"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.426"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INMNIGG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="240"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="420" mass="45736" checksum="099AF603211BD145" modified="2004-10-25" version="1">MTPPVAPPAFTAQPAETAADVARPGVRRVRILFHINDFGRGGTETALLAWLNALDRSAFEVGLSVTYPTADLTMWRAKAIPADVALQVLASDRWMHALHQRERVRRLRGGEKLLHKASTHALIRPAVARRFLRLARGYDVVCDFDFSLRRIAGRGGMPWIGVSHYSFAARFGEKSASYMARRVRQYERYTALAVLTPDMRREAESLFADTRVVVTALPNVIDPQALRARADEPADLPAGRFIVSVARLDEGQKDHRTLLRAYAQVRASRADAPRLVLLGDGPDRGALEQLAAELGLRDAVLFAGFCANPFPYVRAADMLILSSRYEGFGMVIGEAMALGTPVISADCPTGPRDLLDFGRAGLLVPPGAADALADAIERMLADGALRASLVAHATRKIESFGPRAANARMQALAAQLLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W47</accession>
    <name>Q63W47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522517.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107669.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1042"/>
    <dbReference type="EnsemblBacteria" id="CAH35038">
        <property type="protein sequence ID" value="CAH35038"/>
        <property type="gene ID" value="BPSL1042"/>
    </dbReference>
    <dbReference type="GeneID" id="56526798"/>
    <dbReference type="KEGG" id="bps:BPSL1042"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1132"/>
    <dbReference type="eggNOG" id="ENOG503406R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARWGNLQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267642" evidence="1">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="168" mass="17175" checksum="BAB096A6834FDBD5" modified="2004-10-25" version="1">MSVRVRAALPLAAALALAAAALGLSGCGSVGAASGALAGAATGLVTANPAVGVGVGIAVQAATDEAVNRTMKQLHKNQQDAIAQAAGGLAVGETRAWQVKNRVPLENGEGEVRVTRAFQTPLALCKEFAFSVKDGSRADWYLANACQDAHGWQWASAEPAVERWGNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W84</accession>
    <name>Q63W84_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004205947.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107632.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1004"/>
    <dbReference type="EnsemblBacteria" id="CAH35000">
        <property type="protein sequence ID" value="CAH35000"/>
        <property type="gene ID" value="BPSL1004"/>
    </dbReference>
    <dbReference type="GeneID" id="56596185"/>
    <dbReference type="KEGG" id="bps:BPSL1004"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.565"/>
    <dbReference type="eggNOG" id="COG3755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEHAMFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009739">
        <property type="entry name" value="LprI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07007">
        <property type="entry name" value="LprI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266828" evidence="1">
        <location>
            <begin position="31"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="LprI" evidence="2">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="LprI" evidence="2">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="26763" checksum="E8B68D677CCCCB16" modified="2004-10-25" version="1">MTAVRKTLVRFAAAALAGWLAAAAAGAAHAEVAAADPIDVAMRQCLARRDRSSTAGQIQCMDEARQQWQGEVDAAYQRLLKTAPADARRGWQESQRRWLAWRKDEAHLVRAVYETTQGTMYAMANADMRLQPVRERALALRGAADRYYAQPGGGKGAVHRVRPCMRDAACEHALFDMNRYYEKLRARMPADSLPTLVAAQREWAAFRDAMTPLVSESERVDLIGARVATLKRFSETVNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB1</accession>
    <name>Q63WB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transmembrane ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192857.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107605.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0977"/>
    <dbReference type="EnsemblBacteria" id="CAH34973">
        <property type="protein sequence ID" value="CAH34973"/>
        <property type="gene ID" value="BPSL0977"/>
    </dbReference>
    <dbReference type="GeneID" id="56596213"/>
    <dbReference type="KEGG" id="bps:BPSL0977"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.597"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMVYWSF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267227" evidence="8">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="333" mass="33539" checksum="A447828F816DFD0C" modified="2004-10-25" version="1">MHAARAAAIWAALALVACAAFVASLTLGSVPLTSVDALAALVHRAGADPLAADIVRTLRLPRALAGFGCGALLALAGALLQVLLRNPLAEPYVLGVSGGAAAFALVAMIAGGAWWIVDCASFAGALASIAFVLGLARRELWRGEPRDASPRLLLTGVVISAGWFALITLMLAIAPDERLRGILFWLSGDLSGAASPGFALAALAAAACVALPAAPQLNVLLRGDAAAAALGVPVARLRLRVYLIASLAAAAAVTTAGTIGFVGLVVPHALRLAFGNDQRMLLPAAMLAGGAGVMAADLLARTAIAPAQLPVGVMTALIGVPLFLWMLLRGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WC8</accession>
    <name>Q63WC8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysN</name>
        <name evidence="8" type="ordered locus">BPSL0960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522575.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107588.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0960"/>
    <dbReference type="EnsemblBacteria" id="CAH34956">
        <property type="protein sequence ID" value="CAH34956"/>
        <property type="gene ID" value="BPSL0960"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0960"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.617"/>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGHVEYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="10"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="47772" checksum="2CD7F77B555AAF45" modified="2004-10-25" version="1">MSIIENNEDLGVLRFITAGSVDDGKSTLIGRLLYDSKAVLSDQLSALSRAKNKRTVGDELDLALLTDGLEAEREQGITIDVAYRYFATAKRKFIIADTPGHEQYTRNMVTGASTAHAAIILIDATRVTFDAGAAQLLPQTKRHSAIVKLLDLQHVIVAINKMDLVDYSETRFNEIRDAYVKLAQQLGLADVRFVPVSALKGDNIVAASERMPWYAGEPLLNVLETLPVETQAHDALRFPVQWVARQDGSSADDFRGYMGRIEAGEVKVGDEIVVLPSNRTATIAEIIAPVPGGTAAVERAFAGQAVTIRLAEDVDVSRGDTFVPRAQGVEPAKKLEADLCWFDETPLSSQRKYLLKQTTNTVFTKIGAVKQVLDVHTLSHATDRHELKMNDIGRVALTLQKPIVCDTYDAHPGTGAFVLIDEATHHTVAAGMIRAFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WD3</accession>
    <name>Q63WD3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cys regulon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193435.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107583.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0955"/>
    <dbReference type="EnsemblBacteria" id="CAH34951">
        <property type="protein sequence ID" value="CAH34951"/>
        <property type="gene ID" value="BPSL0955"/>
    </dbReference>
    <dbReference type="GeneID" id="56596237"/>
    <dbReference type="KEGG" id="bps:BPSL0955"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.622"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITYDNAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08413">
        <property type="entry name" value="PBP2_CysB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037423">
        <property type="entry name" value="CysB_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="34873" checksum="0C86D62FA967856C" modified="2004-10-25" version="1">MNLHQFRFVREAVRQNFNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRVRSLTEPGRIILASVERILQEVESLKRVGKDYAAQDQGNLTIAATHTQARYSLPAAIAEFKKRFPKVHLSILQGSPTQVAEMVIHDQADLAIATEAIADYKELVSLPCFQWHHAAVVPADHPLLERKPLSLDDLAQFPLITYDDAFAGRKKINQAFALHRLTPDIVLEAIDADVIKTYVELGLGVGIMADIAFNPERDRNLRAIAVGHLFGSNVTRVALKQGAYLRGYIYTLVELLSPTLNRKLVETALKGEAETYEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WH7</accession>
    <name>NADA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Quinolinate synthase</fullName>
            <ecNumber evidence="1">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadA</name>
        <name type="ordered locus">BPSL0912</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:25889"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the quinolinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185886.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107539.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WH7"/>
    <dbReference type="SMR" id="Q63WH7"/>
    <dbReference type="STRING" id="272560.BPSL0912"/>
    <dbReference type="EnsemblBacteria" id="CAH34906">
        <property type="protein sequence ID" value="CAH34906"/>
        <property type="gene ID" value="BPSL0912"/>
    </dbReference>
    <dbReference type="GeneID" id="56594768"/>
    <dbReference type="KEGG" id="bps:BPSL0912"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.670"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFCSTMN"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00567">
        <property type="entry name" value="NadA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023513">
        <property type="entry name" value="Quinolinate_synth_A_type1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000024950" description="Quinolinate synthase">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00567"/>
        </source>
    </evidence>
    <sequence length="378" mass="40828" checksum="FED5490064BC13A8" modified="2004-10-25" version="1">MQSAIKSVEYDRPLAAGAACGVGEAWAKVPDALAPDERDALKARIKALLVREKAVLVAHYYVDADLQALADETGGCVADSLEMARFGRDHDAHTLVVAGVRFMGETAKILSPGKRVLMPDLDATCSLDLGCPVDEFSQFCDAHPERTVVVYANTSAAVKARADWMVTSSIGLEIVADLHARGEKIIWAPDRHLGGYIQKKTGADMLMWQGSCLVHDEFKGIELDLLRHEYPDAKILVHPESPEGVVALADVVGSTTQLIDAAVKLDAQRFIVATDLGILHKMRLAAPGKTFIEAPTAGNSATCKSCAHCPWMAMNALSNLADVLERGHNEIFVEAAIAQRARMPIDRMLDFAARHKQRVQASGDLQRDQALFANVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WK1</accession>
    <name>Q63WK1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534266.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107515.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0890"/>
    <dbReference type="EnsemblBacteria" id="CAH34882">
        <property type="protein sequence ID" value="CAH34882"/>
        <property type="gene ID" value="BPSL0890"/>
    </dbReference>
    <dbReference type="GeneID" id="56526931"/>
    <dbReference type="KEGG" id="bps:BPSL0890"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.700"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PETVYAY"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="4">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="450" mass="47869" checksum="6F2804285E7E0006" modified="2004-10-25" version="1">MPRLSANEAAQLLGVSVPTLYAYVSRGLLRSLADGTSKRRHYDADEVRLLARRRADAKRAGKVAERTLDWGVPVLESRITQIANGTLRYRGRDAISLAMTATLEEAAALLWECPPARVHAAPGAERWFDTARWLGRLDRWRDRPPLERALALLPAAAPDVSDVSDLPDAPPDGGRAAPPADAAPARHRAPPDPPDPPAPAAELDARRRDAQLDEAAMLLRVAAAALAARAPSAEPVHRQFAAAWRLTDPRDAELLRMALVLCADHELNPSTFAVRCIASTGAPLFGAIAGGLAALSGPRHGGETLRVAALLDGAAAARDLERYVAARIAAYECEPDARTRLPGFGHPLYPDGDPRATLLLDALVARASPNAALDGALSLVEAAQAALGDKPTIDFALVALERTLALPPRAAFALFAAGRVAGWIAHALEQRADGKLIRPRARYVGVDHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WM7</accession>
    <name>Q63WM7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550790.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107489.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0864"/>
    <dbReference type="EnsemblBacteria" id="CAH34856">
        <property type="protein sequence ID" value="CAH34856"/>
        <property type="gene ID" value="BPSL0864"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0864"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.732"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EETHKMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="436"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="521" mass="55151" checksum="221627DC52A6CD72" modified="2004-10-25" version="1">MTIEFSPGAAIDADALLDTLPQRIAALPARVAEHAPDHVALIEDGRRLTYAQLARAVEAAAERLRGLGVRGGDRVMIVAENSIAQIVLLFAATRLDAWAIVSNARLSAAELDAIAAHAQPRLIAFVTGTSPDARAHADRRNAHAAAPFELDIGAWSHTVEAGTRAEPVEAHGARQCAALVYTTGTTGAPKGVMLSHRNLLFAAAVSSMQRRVAPTDVVYAVLPISHVYGLASVCLGSLYAGATLRLAPRFSPETLRRALADEGVTIFQGVPAMHAKLLEHLRAHGHAWRAPHLRFVYSGGSPLDADLKARVERAYGLPLHNGYGMTESSPTIAQTPIDAPRADCSVGAPIPGVAVRFCSADGADVAPGEVGELWVRGPNVMLGYYRDPEGTRAAVTAHGWLKTGDLARAGTDGAMTIVGRSKELIIRSGFNVYPSEVEQALNAHPDVVQSAVIGRAAEAGNEDVIAFVELAPNAAATESDLKEWCVGRLAPYKRPVQIRALDALPAASTGKVLKHRLRAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WV0</accession>
    <name>Q63WV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ADP-heptose--LPS heptosyltransferase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">waaF</name>
        <name evidence="2" type="ordered locus">BPSL0791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526219.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107416.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0791"/>
    <dbReference type="EnsemblBacteria" id="CAH34783">
        <property type="protein sequence ID" value="CAH34783"/>
        <property type="gene ID" value="BPSL0791"/>
    </dbReference>
    <dbReference type="GeneID" id="56527030"/>
    <dbReference type="KEGG" id="bps:BPSL0791"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.814"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GSAKRWP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011910">
        <property type="entry name" value="RfaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02195">
        <property type="entry name" value="heptsyl_trn_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="346" mass="37959" checksum="CCF85F6E94A5E613" modified="2004-10-25" version="1">MRRALVIAPNWIGDALMAQPLFALLKKLHPRIVIDAVAPAWVAPVLERMPEIHDVHATELAHGKLQMLHRWQLASDLRELGYDAAYVLPNSLKSALIPWLAGIPLRIGYTGEHRYALLNVRHANPGKARETRAPMAQHYAALAYAPGAKLPESFQTLPPPRLDADLNETARVSARFNLDTRKPLIVFCPGAEYGPAKRWPPEHFAALAQSVSQSFPYTQIVALGSPKDAAAAQAIAERAPNVRSLCGQTSLTEACALIARANAVVTNDSGLMHVAAALRRPLVALYGSTDPRHTPPLSELAKVQWLHLECSPCFERECPLGHLKCLRELSPEQVFGDLRGMLVGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XA1</accession>
    <name>Q63XA1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GBBH-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190130.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107265.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0636"/>
    <dbReference type="EnsemblBacteria" id="CAH34629">
        <property type="protein sequence ID" value="CAH34629"/>
        <property type="gene ID" value="BPSL0636"/>
    </dbReference>
    <dbReference type="GeneID" id="56596669"/>
    <dbReference type="KEGG" id="bps:BPSL0636"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.987"/>
    <dbReference type="eggNOG" id="COG3536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TAINLHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="137" mass="14989" checksum="2D42F84577FD1AE6" modified="2004-10-25" version="1">MSGQAAAAPVPSGIVVHAVSRVLELQYPSGECFRVPFELMRVYSPSAEVRGHGPGQETLQTGKREVTVTALEPVGNYALKPTFSDGHSTGIYSWALLYELATRQDALWREYFDKLKAAGVERDAPMPADSLPRGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XD4</accession>
    <name>Q63XD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204840.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107231.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0602"/>
    <dbReference type="EnsemblBacteria" id="CAH34595">
        <property type="protein sequence ID" value="CAH34595"/>
        <property type="gene ID" value="BPSL0602"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0602"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.653"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NARCARF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="386"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="532"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="787" mass="82700" checksum="AB8EFEC52C86E58C" modified="2004-10-25" version="1">MRSAVAVALAVALLGAALLSVERFGAARSRASAAIPASIGARLSGCAFIAVRIGAALSRRAPSPAHAAAPGVARPDFDAIERVFGPIRMRERRAHGATCTADAPDASHAGWIEPARVCSAAAHAAPGRGAEGAPNTMPRPSEAGAAAVPQSQPYLDMIDSTFREPAAIVLALSLLGMIALALLPVFRIRRLALRLGEAQGALEMSEARARAALVAVGDGVIFTGRAGRVECLNPAAERLIGMLADDCRGRPLVSTLRLSRTPTSASSGAFAASAGLDAPDSPGSAASPDAPLGDLEDGGSCDATLYRADGGAIAVRATASSIAPPPGHARRACGSGRVLVLKSLATEHELVRRLAWQTTHDPLTGLASRAEFERHVGFALAADVREPVALLFVDLDRFRIVNDTCGYAAGDAMLAALAARLVSCAASADVVARLGGDEFCVLLDARDEASAVSAAERLRASVDGFVFVWDGQPFSVTASVGVALLGGPGRAPRVEDAVRLAGIACDVAKARGRNRVQLADPHDHELAHHISDVSWCARVRQALEYDDFRLYVQPIVDTATQGATGLPRARRGELLLRMDALGEREGVAPPGLFIRAAERYGLVTDIDRWVVRTVLDALARTRSRRFSEYAINLSGISIGDERFLDYVLEQFARTRVAPALICFEITETAAIANLAGALRFMHELKALGCRFALDDFGSGMASLSYLKQLPVEYLKIDGSFVTGIANDAASLDIVASINDIGHAMNCKTIAEYVDSAATLQKLAALGVDYAQGYYIGRPVPWCEAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XG9</accession>
    <name>Q63XG9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936279.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107196.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0570"/>
    <dbReference type="EnsemblBacteria" id="CAH34560">
        <property type="protein sequence ID" value="CAH34560"/>
        <property type="gene ID" value="BPSL0570"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0570"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYEDAAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="27015" checksum="4F87AC151AD3BC0E" modified="2004-10-25" version="1">MRLVLAFQSTVAKVTDEPERNEDAVCIDEGRGVFAVADGASESFDSRAWAHLLASRFVELPAVSPEWVNAARQSYDRTWDYNSLGWSEQMAFDRGSFSTLLGCQWQEHLGNLEIVSVGDSVAVHVEAAKVVQSHPYTTAAEFDQRPRLLSTRAEANEFVSAASFNNDSGTVWHLSEGSVVLLMTDALGQWLLSENPAGSRLERLLSVNTDAAFTELVLSERREGVLRIDDTSLLVLAVRSRPQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XK3</accession>
    <name>Q63XK3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KDO 8-P phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11500"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="EC" id="3.1.3.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200146.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107162.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0537"/>
    <dbReference type="EnsemblBacteria" id="CAH34526">
        <property type="protein sequence ID" value="CAH34526"/>
        <property type="gene ID" value="BPSL0537"/>
    </dbReference>
    <dbReference type="GeneID" id="56593796"/>
    <dbReference type="KEGG" id="bps:BPSL0537"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1111"/>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VFMGVEN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="179" mass="18734" checksum="D39196789E01A9A0" modified="2004-10-25" version="1">MSAPPATAAERASRVKLMIFDVDGVLTDGGLHFTAAGDAMKSFNTLDGHGVKLLGEAGIATAIITGRRSEALAARAKEMRIAHLHEGVENKLAVFGELLRALGLEPGECGYMGDDWPDLAVMLRCGFAAAPANAHPDVIARAHWVAEARGGHGAVREVCDAILRAQHRYDALLAAACGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XT7</accession>
    <name>Q63XT7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="19">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ordered locus">BPSL0453</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 19">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="19">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="19"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526023.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107078.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0453"/>
    <dbReference type="EnsemblBacteria" id="CAH34441">
        <property type="protein sequence ID" value="CAH34441"/>
        <property type="gene ID" value="BPSL0453"/>
    </dbReference>
    <dbReference type="GeneID" id="56594482"/>
    <dbReference type="KEGG" id="bps:BPSL0453"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.508"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAFMPIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0186">Copper</keyword>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266860" description="Cytochrome c oxidase subunit 2" evidence="22">
        <location>
            <begin position="34"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="24">
        <location>
            <begin position="40"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="23">
        <location>
            <begin position="136"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="25">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="26">
        <location>
            <begin position="416"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAH34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="525" mass="55948" checksum="0F7C12EF3864E2CD" modified="2004-10-25" version="1">MEILGKEAMKTIKRALTGVLACSALLLSGAALAVGDSPGGPRVNEINLQPPVTKIAEELYDLHTMMLILCTVIFVGVFGVMFYSIFAHRKSKGHKAANFHESTTVEIIWTIVPFIIVVLMALPATKAVVAMKDTTNADLTVKVTGYQWKWGYDYVKGPGEGISFLSTLSTPRTEVNGRQPISDTYLQEVDHPLVVPVNKKIRVITTANDVVHSWYVPAFGVKQDAIPGFVRDTWFKAEKVGTYRGFCTELCGKEHAYMPVVVEVLSDDDYAKWVSTQKAKLAAGAVDPNKVYTRAELMAHGEEVYKANCAACHQPNGKGVGAFPALDGGKIVNGPIAGHLEQVLKGKGAMPSWASLSDLDIASVITYERNSWGNHKGDSLQPKQVADARNGKLPEDAQQADGGAAANAASGAAAQTQAQAPALPAAIYFETGKSELPADAKDAIAAAAEYVKAHPDAKLALSGFTDKTGSADANAELAKRRAQVVRDALKTAGVAEDRIILKKPETITGGADAKEARRVEIGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y42</accession>
    <name>Q63Y42_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ordered locus">BPSL0346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530993.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106973.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0346"/>
    <dbReference type="EnsemblBacteria" id="CAH34335">
        <property type="protein sequence ID" value="CAH34335"/>
        <property type="gene ID" value="BPSL0346"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0346"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.386"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHFAMNE"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="32022" checksum="2AE345465AE00295" modified="2004-10-25" version="1">MHMQSRFEGIWLPIVTPFHARETGTVDHAALARLARHYSDEGIAGFVAGATTGEGALLNAGEQEAIFATLRDAAPARPIVLGITASATHAAAERARALAALRPDGLLVTPPVYVRPTQAGVQRHIEAVVEAADLPVLVYNIPYRTGVNVELDTLKALSRDARVAGVKECGGTMERMLRLVHETPLRILSGDDNQNFAALCAGAHGAIASAAHVLPAWHVRVYALLREGRLDDARRIAVALQPLVADLFAEPNPAPVKALLAAQGWCDNALRLPFLPVEEALATRLVAHWESLRQSEAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC5</accession>
    <name>Q63YC5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197236.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106890.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0263"/>
    <dbReference type="EnsemblBacteria" id="CAH34251">
        <property type="protein sequence ID" value="CAH34251"/>
        <property type="gene ID" value="BPSL0263"/>
    </dbReference>
    <dbReference type="GeneID" id="56594386"/>
    <dbReference type="KEGG" id="bps:BPSL0263"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1445"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFNRFAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="34020" checksum="8D74CF7EEC3F677E" modified="2004-10-25" version="1">MQGQTIAMLGGTGFIGSRLVNVLVGAGAHVRIGARRREHARHLATLPVDIVELSAFDVRELARFVAGAQAAVNLVGVLRGGHGKPYGEGFERLHVALPAALAAACIEARVPRMLHVSALGADPHAPSMYLRSKGDGEIALRAQAAAGALDVTIFRPSIVFGPGDAFVNTFARLQRIFPVLPLAMPDALMQPVHVGDVAQAIANACVRDATRGRTYELGGPRTYRLEEIVRYAGRLIGRPARIVRLPDALARLQARVFEMLPGEPLVSRDNLASLSVPSVMTGPIAPELGIAPASLEHIAPTYVGDAALRSRFSDRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC8</accession>
    <name>Q63YC8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197230.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106887.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0260"/>
    <dbReference type="EnsemblBacteria" id="CAH34248">
        <property type="protein sequence ID" value="CAH34248"/>
        <property type="gene ID" value="BPSL0260"/>
    </dbReference>
    <dbReference type="GeneID" id="56594389"/>
    <dbReference type="KEGG" id="bps:BPSL0260"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1448"/>
    <dbReference type="eggNOG" id="COG5631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVNHRGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014601">
        <property type="entry name" value="Trans_reg_MarR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13463">
        <property type="entry name" value="HTH_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036158">
        <property type="entry name" value="UCP036158_MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="170" mass="18866" checksum="A3451A4F8E871606" modified="2004-10-25" version="1">MQRHPTKIVSSEHLVSETSAELSELEYALIMAGNAFNRWMVRCMAAAGAKDMTAVEVSLLHHVSHRDRKKKLADICFVLNIEDTHVATYALKKLVARGYVKSEKTGKEVFFDATDAGRALCLRYRDVRERCLIETLKDSGLTNEQIGDAAQLLRHASGLYDTAARAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YF4</accession>
    <name>Q63YF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197170.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106861.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0233"/>
    <dbReference type="EnsemblBacteria" id="CAH34221">
        <property type="protein sequence ID" value="CAH34221"/>
        <property type="gene ID" value="BPSL0233"/>
    </dbReference>
    <dbReference type="GeneID" id="56594418"/>
    <dbReference type="KEGG" id="bps:BPSL0233"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1479"/>
    <dbReference type="eggNOG" id="ENOG5032ZWZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHLQEEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008622">
        <property type="entry name" value="FliT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05400">
        <property type="entry name" value="FliT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="12198" checksum="5E44A65667B3C268" modified="2004-10-25" version="1">MNRKDEYFARYEAIAAVSGRMLVAARDAAWHAMGGLQEEYLRLVDGLKEAEQGVLLDDAERTRKFELIRRILADDAAIRDLASPEVARLSAFFHAGRSTLKDLYRARG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YH7</accession>
    <name>DAPF_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Diaminopimelate epimerase</fullName>
            <shortName evidence="1">DAP epimerase</shortName>
            <ecNumber evidence="1">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapF</name>
        <name type="ordered locus">BPSL0210</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545660.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106838.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YH7"/>
    <dbReference type="SMR" id="Q63YH7"/>
    <dbReference type="STRING" id="272560.BPSL0210"/>
    <dbReference type="EnsemblBacteria" id="CAH34197">
        <property type="protein sequence ID" value="CAH34197"/>
        <property type="gene ID" value="BPSL0210"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0210"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1507"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000011860" description="Diaminopimelate epimerase">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <sequence length="289" mass="30846" checksum="7B64B0F836638C29" modified="2004-10-25" version="1">MKLSFTKMHGAGNDFVVLDGYTRALPPLTGAQVRALADRHFGIGADQLLLVEKPTVDGADFKYRIFNCDGGEVEHCGNGARCFVKFVRDHGLTGKASVRVEVKHGVITLTMQDNGEVVVDMGAPVFEPARVPFDASGLDGRREGADTLWPLPVNGVTRWISVVSMGNPHAVQIVDDAEAFAVRVDGPAIECDPRFPQRVNAGFMQIVSRHEVNLRVYERGAGETLACGTGACAAVAAGIRRGRLDSPVTVHTHGGTLTISWNGACDERAPLMMAGPATTVFEGVIELPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YI7</accession>
    <name>ARGB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylglutamate kinase</fullName>
            <ecNumber evidence="1">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAG kinase</fullName>
            <shortName evidence="1">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argB</name>
        <name type="ordered locus">BPSL0200</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200214.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106828.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YI7"/>
    <dbReference type="SMR" id="Q63YI7"/>
    <dbReference type="STRING" id="272560.BPSL0200"/>
    <dbReference type="EnsemblBacteria" id="CAH34187">
        <property type="protein sequence ID" value="CAH34187"/>
        <property type="gene ID" value="BPSL0200"/>
    </dbReference>
    <dbReference type="GeneID" id="56594454"/>
    <dbReference type="KEGG" id="bps:BPSL0200"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1519"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112601" description="Acetylglutamate kinase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <sequence length="299" mass="32119" checksum="B97234627B73D564" modified="2004-10-25" version="1">MSEPIDLSQISPALKAEILAEALPYIRRYHGKTVVIKYGGNAMTEERLKQGFARDVILLKLVGINPVIVHGGGPQIDQALKKIGKQGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVTLINHFGGHAVGLTGKDGGLIHARKLMMPDRDNPGEYVDIGQVGEVEAINPAVVKALQDDAFIPVISPIGFGEDGLSYNINADLVAGKLATVLNAEKLVMMTNIPGVMDKEGNLLTDLSAREIDALFEDGTISGGMLPKISSALDAAKSGVKSVHIVDGRIEHSVLLEILTEQPFGTMIRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK4</accession>
    <name>Q63YK4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan D,D-transpeptidase MrdA</fullName>
            <ecNumber evidence="2">3.4.16.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Penicillin-binding protein 2</fullName>
            <shortName evidence="2">PBP-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">mrdA</name>
        <name evidence="6" type="ordered locus">BPSL0183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes cross-linking of the peptidoglycan cell wall.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transpeptidase family. MrdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204769.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106811.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63YK4"/>
    <dbReference type="STRING" id="272560.BPSL0183"/>
    <dbReference type="EnsemblBacteria" id="CAH34170">
        <property type="protein sequence ID" value="CAH34170"/>
        <property type="gene ID" value="BPSL0183"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0183"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1536"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02081">
        <property type="entry name" value="MrdA_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="61"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="283"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="818" mass="86743" checksum="E8D4504E817896DC" modified="2004-10-25" version="1">MTEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAPIVPNRGIITDRNGVVLAKNYSAYTLEITPSKLADTLDNTINALAEVVQIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRWRFPGVDVRARLFRQYPLGPTAAHVIGYIGRISKRDQDRIDAMSDENDSDPETYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVEVTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLALGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVTAIANFMKPFGFGQLTGIDIQGEARGILPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLAHATATLANDGVIMKPHLVKEVENPISRARHLTVPKESGVIPLKQNDLDVVKRGMENVVESPSGTAFKVFRGAPYLAAGKTGTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLLERKNPSTEAAAVAAAASATEPVNAPVIGDATKPVGIAAGFKALPQPMPLASASGADGASGASGASGASGASGASGASGAGGEPTEHANAGGNSAGGGIAGGAAGTANNGSGAAAPGGMPGANGAATGAPPASRRLPPRKPRRTPASDAAISAAASRDDPRKPSSGAPKTPAQDDNHAVSAARPAAGGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR0</accession>
    <name>Q63YR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009935896.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106755.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0128"/>
    <dbReference type="EnsemblBacteria" id="CAH34114">
        <property type="protein sequence ID" value="CAH34114"/>
        <property type="gene ID" value="BPSL0128"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0128"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1594"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQFSFDM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="227" mass="24245" checksum="22D4D25B5B35BDF3" modified="2004-10-25" version="1">MATILVVDDEMGIRELLSEILSDEGHVVDVAENAQAARDYRLRQAPDLVLLDIWMPDTDGVTLLKEWASQGQLTMPVIMMSGHATIDTAVEATKIGALDFLEKPITLQKLLKSVEHGLARGAAPLPASAAVKPAAGAAVASAAALPTLGDDPAVALAGQTTAAIPFDIPLREARDAFERAYFEYHLARENGSMTRVAEKTGLERTHLYRKLKQLGVELGKKPAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR5</accession>
    <name>Q63YR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative LysE type translocator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189288.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106750.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0123"/>
    <dbReference type="EnsemblBacteria" id="CAH34109">
        <property type="protein sequence ID" value="CAH34109"/>
        <property type="gene ID" value="BPSL0123"/>
    </dbReference>
    <dbReference type="GeneID" id="56596708"/>
    <dbReference type="KEGG" id="bps:BPSL0123"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1600"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HSLACAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="22294" checksum="8D4E7DD245188DC1" modified="2004-10-25" version="1">MFGITHLGLFMAAVFLLNITPGPDTAYIVGRSVAQGRGAGLMSALGISAGCCVHVLACAFGLTAVLAASATAFTVIKVVGAAYLVYLGVRLIFAKQEPAAERPARRGADKSLRQLFMQGFLTNVLNPKVVLFFVSFFPQFVSVDSNHKVLAFLMLGAVFLAMSTVWSCTVAWVAGTVTRRFAGKPGVKKWLDRGVGSAFVGLGVKLATSTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>P0DMK7</accession>
    <accession>O31395</accession>
    <accession>Q63LH5</accession>
    <name>IRLR_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional activator protein IrlR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">irlR</name>
        <name type="ordered locus">BPSS1040</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by IrlS.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197868.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111046.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0DMK7"/>
    <dbReference type="SMR" id="P0DMK7"/>
    <dbReference type="STRING" id="272560.BPSS1040"/>
    <dbReference type="EnsemblBacteria" id="CAH38501">
        <property type="protein sequence ID" value="CAH38501"/>
        <property type="gene ID" value="BPSS1040"/>
    </dbReference>
    <dbReference type="GeneID" id="56597413"/>
    <dbReference type="KEGG" id="bps:BPSS1040"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4228"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGQDDAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006291">
        <property type="entry name" value="PcoR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01387">
        <property type="entry name" value="cztR_silR_copR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0104">Cadmium</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000081112" description="Transcriptional activator protein IrlR">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <sequence length="229" mass="25985" checksum="9DC97F0F2FC83887" modified="2014-07-09" version="1">MRILIVEDEPKTGMYLRKGLTEAGFIADWVEDGVTGLHQAETEEYDLIILDVMLPGHDGWTVLERLRRAHSTPVLFLTARDDVGDRVKGLELGADDYVVKPFDFVELVARVRSILRRGQARESTVLRIADLELDLTRRKATRQGDVVLLTAKEFALLWLLMRREGEILPRATIASQVWDMNFNSDTNVVDAAIRRLRSKIDDAYEPKLIHTVRGMGYVLEVRSASAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HX7</accession>
    <name>Q63HX7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552284.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112295.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2292"/>
    <dbReference type="EnsemblBacteria" id="CAH39778">
        <property type="protein sequence ID" value="CAH39778"/>
        <property type="gene ID" value="BPSS2292"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2292"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5913"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAQGLSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="36482" checksum="87F543B00820887C" modified="2004-10-25" version="1">MYRHFLVPVDDTDAGIDTVAYALEFARSIGARITFVQTRIEFEAADAARRIGETERKEQTQRTDDAGKSGECGRSDESVRPAPTPDAAARPAAEATPAARAPELPIAKAEAAARAQGVPCDSVRAAGATTADALAGAMLAHDCDLLCVGPALGDAAAAPPHACVADRLAARGIAVLTCAFRRTPAAARAIAALYAAHREAAGALGAWLAQLRAAIAAGRALDADAAHAIANGLSHLRDGRQPKAARRLYAALRSATGALDAELGELERQRLRNARMLSGLLEAIHAGIAREAPPVRLEHALSAYAQCVCEHAGRGEGVIVPAAQRYLADDDWRAIDASLALIASGPAAAARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IR6</accession>
    <name>Q63IR6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530211.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112006.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2000"/>
    <dbReference type="EnsemblBacteria" id="CAH39478">
        <property type="protein sequence ID" value="CAH39478"/>
        <property type="gene ID" value="BPSS2000"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2000"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5514"/>
    <dbReference type="eggNOG" id="COG3794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TLTIKDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266478" evidence="2">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="12251" checksum="73D46A9CD2AF02D5" modified="2004-10-25" version="1">MKTLQTISSLALALAFAVSAPHAFAADDAYSLTLKNHRFSPADLTIPAGKKVKVTIKNLDATPAEFESDDFKAEKVVPAGKQVDVYIGPLKAGTYEFHDEYHEAESKAKLTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IT5</accession>
    <name>Q63IT5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FrmR/RcnR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941095.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111987.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1981"/>
    <dbReference type="EnsemblBacteria" id="CAH39459">
        <property type="protein sequence ID" value="CAH39459"/>
        <property type="gene ID" value="BPSS1981"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1981"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5485"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DCGPILQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="91" mass="10253" checksum="8BD9460CCC5AFAD9" modified="2004-10-25" version="1">MSHTIREKQKLLNRVRRIKGQVEAIERALKEECGCGEVLQRITSCRGAMNGLLAVVLEDHIRTHLVDADTGDNHEGSASEQLIDVVHSYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J16</accession>
    <name>Q63J16_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529142.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111906.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1900"/>
    <dbReference type="EnsemblBacteria" id="CAH39378">
        <property type="protein sequence ID" value="CAH39378"/>
        <property type="gene ID" value="BPSS1900"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1900"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5368"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWVAMHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="33941" checksum="29820D1387D9EACC" modified="2004-10-25" version="1">MGSEIGWELYRSFLGVLREGSLSGAARALGLTQPTVGRHVAALEAALRVPLFTRSSSGLMPTDVALALRAHAEAMESTADALARAATSFGEDVRGVVRISASDVVGVEVLPPIVARLRQRHPALTVELALTNRVQDLLRREADIAVRMTRPGQTQLIARHIGGIELGLHAHRDYLARCGTPRDAGELVRHALIGHDRPTAFIRQIAKSFPGFDRGAFALRTDSDLAQLALIRCGAGIGACQAALAKRDPALVRVLPKAFAGRLDMWVTMHEDLRGSPRCRAAFDALAEGLDAYVDEQRAPAIARRRRPLPGTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J63</accession>
    <name>Q63J63_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205691.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111859.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1855"/>
    <dbReference type="EnsemblBacteria" id="CAH39331">
        <property type="protein sequence ID" value="CAH39331"/>
        <property type="gene ID" value="BPSS1855"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1855"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5308"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQIVNTS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="24649" checksum="B6BBFA773DF2FF2E" modified="2004-10-25" version="1">MTELLLIRHAQASFDAADYDCLSPLGDEQSARLGAWMARGARRPALIATGTLRRHAQTADGCARAAGVDAPRLALAGLDELDADELIARHRPALASRDALLRAMAAEADPRRAFQTLFAAAVARWTGGAHDGEYGCAWPEFRARTLAAWDALAGQPAREIWAFTSGGPIGVIVAALFGVPAECSFELAWPLVNTSVTRIRIGRGGARVTTYNGWPHLDGERDERLVTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JF7</accession>
    <name>Q63JF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190760.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111765.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1759"/>
    <dbReference type="EnsemblBacteria" id="CAH39234">
        <property type="protein sequence ID" value="CAH39234"/>
        <property type="gene ID" value="BPSS1759"/>
    </dbReference>
    <dbReference type="GeneID" id="56598185"/>
    <dbReference type="KEGG" id="bps:BPSS1759"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5190"/>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RCNFTNM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="43570" checksum="75D4FA12D6ADCC0C" modified="2004-10-25" version="1">MEKFDIAVIGAGAAGMMTAAVAGQLGRRVVLLDHSPRLAEKIRISGGGRCNFTNLYAGPDNYLSANPHFCRSALARYTPRDFLGLLKNHRVTWHEKHKGQLFCDHSSDAIIDVLKSECDAGGVAWRRPVTVDAVRHAQADGFALDTSAGAIGAQALVVATGGLSIPKIGATDFAYRIAKQFGHKLVDTRPALVPLTFSADAWAPFAALSGVSLEARVSTGAKRGGGEFVEDILLTHRGLSGPGILQISSYWRSGEPIHVDLAPQIDAANELIRAKAGSRRQIGTLLAEWVPARLAHAWLEAERVHADARLADLPDKTLRRIGETLSRWTLTPSGTEGYRKAEVTKGGVDTRELSSATMMSERVPGLFFVGEALDVTGWLGGYNFQWAWASGVAAGRAAADGTRRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JG6</accession>
    <name>Q63JG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111756.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1750"/>
    <dbReference type="EnsemblBacteria" id="CAH39225">
        <property type="protein sequence ID" value="CAH39225"/>
        <property type="gene ID" value="BPSS1750"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1750"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5177"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPEWGVR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="PTHR20974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="204" mass="21637" checksum="3C2743C40E63E6A9" modified="2004-10-25" version="1">MPIDSASRQWAPAAERNREPILAVLKRVLPARGAVLEIASGTGQHAVHFAAALPDLVWQPTDVDAAARESIAAWAADAALPNLRAPLALDVCVEPWPLAAADAIVCVNMIHIAPWAAVCALFVGAARALPDGGVLYLYGPYRRGGAHTTESNAQFDAQLRRRNPAWGVRDLEAVVELGGASGLALDEVVEMPANNLSVVFRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI4</accession>
    <name>Q63JI4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111738.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39207">
        <property type="protein sequence ID" value="CAH39207"/>
        <property type="gene ID" value="BPSS1732"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1732"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6044"/>
    <dbReference type="OMA" id="GAMMFAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="21692" checksum="5B673299F5501FEE" modified="2004-10-25" version="1">MPAFSMDVGRARSARAALHGAAGWLACLLPVAVAHAPAFWAWNALAAAACAAAGAGQARASVHSRRSPLAGVAVLSGAQLADFASTYPDAVLALCSSASFVDDWVLHVRLFPFTAAAMVGLSVAAARGERGRRTRWPKRIVDAAVALGAMMFAMNLAAMLLKTWAGLAGWPWGAHALVCTMLVGMMLDHAAMRTMSDAIAAQRASHAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI5</accession>
    <name>Q63JI5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pigment biosynthesis-related tyrosinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111737.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1731"/>
    <dbReference type="EnsemblBacteria" id="CAH39206">
        <property type="protein sequence ID" value="CAH39206"/>
        <property type="gene ID" value="BPSS1731"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1731"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6042"/>
    <dbReference type="eggNOG" id="ENOG502Z83Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FIDYMFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="2">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="537" mass="58938" checksum="F07C2BCFDC1FF15F" modified="2004-10-25" version="1">MTMSNVNAPRVRRSVRDLQKLYDNGEKKPLEDLVRAWAGIQALPPSDPKSFFALGGYHGEPFQYRKPVDALPQSDIYPYWGGYCNHGNVLFPTWHRMYVYKLEEALQSIVPGVSMPFWDETDEYTLRHGIPSILTQETFELDGTPIDNPLRSFVLPDALSDRLPGDGSIYEKPKGYLTVRYPLSGLVGTPEALEQTKLHNAKFPLPEKNTELLNGNVRAWLRGDSPTPDDPDPTRNGVYAKYVRCLSAPNYTVFSNTTSASVWSSSNPGLVTAVESPHNDIHLAVGGFDYGGGETGQIAGANGDMGENNTAGMDPIFFFHHCNVDRMFWVWQKQTGHTDRLDIIRNYPGTNASDSQGPTPGFAPGESLNLKTPLNPFKKASGEAYTSEDCINIERQLGFTYGPGSLDDVTPELKSLLAVPSGNSTKKLTVTGIDRALIQGSFIMKAYASVTDANGKTREYYLGHKSILSRWNVVHCANCLTHLDVVAHFPLSAMPADDVPKAEFRVKIIHRGGGVPSASKAAIGVVSGLQPNFEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP5</accession>
    <name>Q63JP5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525217.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111677.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1672"/>
    <dbReference type="EnsemblBacteria" id="CAH39145">
        <property type="protein sequence ID" value="CAH39145"/>
        <property type="gene ID" value="BPSS1672"/>
    </dbReference>
    <dbReference type="GeneID" id="56529918"/>
    <dbReference type="KEGG" id="bps:BPSS1672"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5074"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRDKLHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="440" mass="47995" checksum="EF4E95AAA4D40BCD" modified="2004-10-25" version="1">MTQSTIPFGIMLQGAGSHMNAWRHPSNPPDASVNLDFIVRIARQAEANGIAFAFVADGLYINEKSIPHFLNRFEPISLLSALATATSRIGLAGTVSTSYSEPFTVARQFASLDLLSGGRAGWNVVTTPLEGTAKNYGTRHPEHDLRYEIADEYLSVAQGLWDSWDDDAFVRDRASGRFFDRDKLHALDHAGRFFEVAGPLNIQRSPQGQPVIFQAGSSDAGIALAGKYADAVFTHAPSLDETRAFARRVKDSAIAHGRRADDVKIFPGIGPIVGRTAAEAEEKYRAIRELLTIDEALAYLGRYFDHHDFTQYPLDAPFPELGDVGRNSFRSTTDRIKAEARAKGLTLRETALAVATPRPQFIGAAHDVADALIRWIDAGAGDGFILGFAVQAQGLDDFVELVIPALEARGRYRRTLVGSTLRDHLGLPRKESRRAAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ2</accession>
    <name>Q63JQ2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein FdhE homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">fdhE</name>
        <name evidence="2" type="ordered locus">BPSS1664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for formate dehydrogenase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FdhE family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551971.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111670.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1664"/>
    <dbReference type="EnsemblBacteria" id="CAH39138">
        <property type="protein sequence ID" value="CAH39138"/>
        <property type="gene ID" value="BPSS1664"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1664"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5063"/>
    <dbReference type="eggNOG" id="COG3058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PKNLYQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16341">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00611">
        <property type="entry name" value="FdeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689">
        <property type="entry name" value="PTHR37689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018296">
        <property type="entry name" value="Format_dh_formtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01562">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="322" mass="34972" checksum="18C11354B543DD15" modified="2004-10-25" version="1">MTDPTQRILDPSEIASLDHSAIPRVRMPERGAVFAARAARLRKLADLNPIAGYLRLMAAVADAQHELLQTFVPNTPEKAAAERAQRHSMPLMPALGGERDPRWRDLLQSLLDRVERAGLVNPPLAKLIDGMRLREAAALDAQADALVAQRFAEIEPASAPFLMAALQVVWTALASRIAPADVPYLEQPGLCPVCGAQPVASIVRVGGQYQGYRFLQCGLCSTEWHMVRTKCSHCDSTKGIAYHGIEGGSEAIKAESCDACHTYRKIGYQEKDYDVEPLADDLASLTLDLLMGEAGYRRASPNPLLWPDLPAEAGAAAGDERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JX0</accession>
    <name>Q63JX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188293.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111602.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1594"/>
    <dbReference type="EnsemblBacteria" id="CAH39069">
        <property type="protein sequence ID" value="CAH39069"/>
        <property type="gene ID" value="BPSS1594"/>
    </dbReference>
    <dbReference type="GeneID" id="56597946"/>
    <dbReference type="KEGG" id="bps:BPSS1594"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4975"/>
    <dbReference type="eggNOG" id="ENOG502ZUIR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VWMAQAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009987">
        <property type="entry name" value="IM_PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041883">
        <property type="entry name" value="PilM_N-ter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07419">
        <property type="entry name" value="PilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267279" evidence="1">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="16060" checksum="04905E7369A2FDE3" modified="2004-10-25" version="1">MYALAAALAFASLAAVYAALQGPAAVPALQPARAAQALADNLAVYRQAALDYARAHPGTRGAVPNARLAFPAWYPGADPLWRNYVENGTVVAYAASAPPVNIAGEVATLAEGSLLAGVAYRGAVVRPGRADPNAPASGVPLPAGLAIADGLPVWMGQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KB2</accession>
    <name>Q63KB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537316.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111460.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1454"/>
    <dbReference type="EnsemblBacteria" id="CAH38925">
        <property type="protein sequence ID" value="CAH38925"/>
        <property type="gene ID" value="BPSS1454"/>
    </dbReference>
    <dbReference type="GeneID" id="56530132"/>
    <dbReference type="KEGG" id="bps:BPSS1454"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4786"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGTIGNP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021763">
        <property type="entry name" value="DUF3326"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36891">
        <property type="entry name" value="PTHR36891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11805">
        <property type="entry name" value="DUF3326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="454" mass="48013" checksum="5A0C156D93AB18B2" modified="2004-10-25" version="1">MHIHEKAFSVSGPLASASLDHLRELTRQQLGPDETPVRFVVTRSDEHGFDCEIGVLSDGEMPESMRADGLFRCERRTRGGGGEFNAVLIVPTGVGAEIGGHDGDAGPVAMLLSSICDRLITHPNVVNAADINELPANGLYVEGSVICRLLLGQIGLQPVRANRVLAVVGSNECPTFVNAAINAVNAARAAYGLDCPRVLHLDPGIRLTSTYASSGRAAGTVENLDALVALLAEHRDTFDAVAIASHIHVPDACRTGYYAGTLGLVNPWGGVEAMLTHTLSTLFSVPSAHSPMYEDPRFAVRDYGIVDPRIAPEVVSLTFLQCILKGLRRAPRIVELARAGNAAGTLSVSDVSCIVIPQGCVGLPVLAALAQRIPVIAVRENRNVMRNDLRSLPWAPGQLRIVDNYWEAAGVLASMRAGLNPDSVRRPLASVDVVRASAAHAHGASSIATAANIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KJ2</accession>
    <name>Q63KJ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sarcosine oxidase beta subunit</fullName>
            <ecNumber evidence="2">1.5.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soxB</name>
        <name evidence="2" type="ordered locus">BPSS1369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.3.1" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524302.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111380.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63KJ2"/>
    <dbReference type="STRING" id="272560.BPSS1369"/>
    <dbReference type="EnsemblBacteria" id="CAH38841">
        <property type="protein sequence ID" value="CAH38841"/>
        <property type="gene ID" value="BPSS1369"/>
    </dbReference>
    <dbReference type="GeneID" id="56530207"/>
    <dbReference type="KEGG" id="bps:BPSS1369"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4683"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VPLDWEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006278">
        <property type="entry name" value="SoxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01373">
        <property type="entry name" value="soxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="414" mass="45097" checksum="E99884FB9043AE11" modified="2004-10-25" version="1">MSRYSIFSLFRNGLSYHENWEKQWKSPEPKREYDVVIVGGGGHGLATAYYLAKEHGVTNVAILEKGWIGGGNTARNTTIVRSNYLWDESAGLYEKAMKLWEGLAQDLNYNVMFSQRGVMNLAHTLQDVRDTERRVNANRLNGVDAEFLTPAQIKEIEPTINLNSRYPVLGASIQRRGGVARHDAVAWGFARGADRAGVDIIQNCQVTGIRREGGAVVGVDTVKGFIKAKKVAVVAAGNTTTLADMAGVRLPLESHPLQALVSEPIKPVVNTVVMSNAVHAYISQSDKGDLVIGAGIDQYTGFGQRGSFQIIEGTLEAIVEMFPVFSRVRMNRQWGGIVDVSPDACPIISKTDVKGLYFNCGWGTGGFKATPGSGWVFAHTIARDEPHALNAPFALDRFYTGHLIDEHGAAAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP8</accession>
    <name>Q63KP8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524252.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111323.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1313"/>
    <dbReference type="EnsemblBacteria" id="CAH38784">
        <property type="protein sequence ID" value="CAH38784"/>
        <property type="gene ID" value="BPSS1313"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1313"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4606"/>
    <dbReference type="eggNOG" id="ENOG5031SFK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTFWYRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="213" mass="22906" checksum="2B6FB7563DCAD59E" modified="2004-10-25" version="1">MKLSPGLVAELTVNLLLPWAAYRAALPYWGETGGLIASAVPPLVWSTVQLARFRRVDALSALVLFGIVLSIAAALAGGSARMLLMRESLASGAIGVAFLASLALRKPLVFHLARATLAREAHDGAARLDALWAERPAFVASMRLMTLVWGCGLVAENLLRAWMVWNWPVERVLVVAPFVGYGVYGALMMWTLWYRKVMRANALAGLPPGGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LE4</accession>
    <name>Q63LE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage terminase, endonuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531049.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111077.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1066"/>
    <dbReference type="EnsemblBacteria" id="CAH38532">
        <property type="protein sequence ID" value="CAH38532"/>
        <property type="gene ID" value="BPSS1066"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1066"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4263"/>
    <dbReference type="eggNOG" id="ENOG5030DH1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KHGWVMP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010270">
        <property type="entry name" value="Phage_P2_GpM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05944">
        <property type="entry name" value="Phage_term_smal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="24456" checksum="E68D8C2DE776383E" modified="2004-10-25" version="1">MTINTPARAHFNRVSAARAAAAASPGATMKGATAYELMLAKLAADRRALKGIQSIERKIELKRKLLPEYADYVAGVLSGGRGAQDDVLVTVMVWRIDAGDFDGALAIAAYALSNGLTLPDQFERSLASLVAEQFADAALSSFLDGETFDAASLELVDDLTREADMHDQVRAKLYKALGYATQAAAPARALDYLRRAVALNDRVGVKKDIDRLTKQVEAAGRRGDGADGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LH1</accession>
    <name>Q63LH1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38505">
        <property type="protein sequence ID" value="CAH38505"/>
        <property type="gene ID" value="BPSS1044"/>
    </dbReference>
    <dbReference type="GeneID" id="56597418"/>
    <dbReference type="KEGG" id="bps:BPSS1044"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4234"/>
    <dbReference type="eggNOG" id="ENOG5030XET">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="46" mass="4694" checksum="5BE72C364D9A43B6" modified="2004-10-25" version="1">MSLAAQDLIELLRLAQGGAGALTLHLLREIAGNLIAFGVADCRGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LN0</accession>
    <name>Q63LN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histidine transport ATP-binding protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="10" type="primary">hisP</name>
        <name evidence="10" type="ordered locus">BPSS0983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110991.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0983"/>
    <dbReference type="EnsemblBacteria" id="CAH38445">
        <property type="protein sequence ID" value="CAH38445"/>
        <property type="gene ID" value="BPSS0983"/>
    </dbReference>
    <dbReference type="GeneID" id="56530561"/>
    <dbReference type="KEGG" id="bps:BPSS0983"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7303"/>
    <dbReference type="eggNOG" id="COG4598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH38445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="255" mass="28122" checksum="0AD6AB9B5F30A632" modified="2004-10-25" version="1">MDKLTVDDLHKKFGDNEVLKGISLRAKAGDVISIIGSSGSGKSTFLRCINFLEQPCSGAITLGGETIRVTRDRRGAPRIGDPKQLQRMRVKLAMVFQHFNLWAHMTVLENVTEAPVSVLGLSRAEADARAREYLRKVGLAPGVEAKYPSHLSGGQQQRVAIARALAMEPEVMLFDEPTSALDPELVGEVLKVMQALAEEGRTMIVVTHEMGFARNVSNHVIFLHQGRIEEEGHPQDVLVHPKSERLSQFLSGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LT1</accession>
    <name>Q63LT1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110940.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38394">
        <property type="protein sequence ID" value="CAH38394"/>
        <property type="gene ID" value="BPSS0931"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0931"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7231"/>
    <dbReference type="OMA" id="RIYATHI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="29803" checksum="936791FAD1CD2E27" modified="2004-10-25" version="1">MPRVHRAFASLQTHYKKLDTAQKLYLNCALALLLYGVTYPLHAWWNFVGLALLSLAFWFAGMVCDALTLYKRIYATHIGKGLLLLAFTGFTNFAIALANQRINAFAGVDPSKFPHTEIFVAILSIPFIALLILMMLYTASVLFLPVYGVFFIAMDAKAKAFFSAGLMKQDDSEYPVITGIFRFVSFFVFAGVVLFFAKRMLGDYDRFMTSTAERSVYQLEMYEKSPCDVPAGARVAFLDDGNIVYALRVGAELKFFPQRCKRSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M06</accession>
    <name>Q63M06_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbsK</name>
        <name evidence="8" type="ordered locus">BPSS0853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528130.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110865.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0853"/>
    <dbReference type="EnsemblBacteria" id="CAH38316">
        <property type="protein sequence ID" value="CAH38316"/>
        <property type="gene ID" value="BPSS0853"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0853"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7139"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECALIVL"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="310" mass="32606" checksum="A58CAE50FC96754C" modified="2004-10-25" version="1">METIAVIGSNMVDLVTYVTRMPADGETLEAPNFELGCGGKGANQAVAASKLGARVAMISKLGDDLFAENTLRNFERFGVDTEHVRRVSGVSSGVAPIFVSPDSRNRILIVKGANRHLRPADIDAAAAKIEASRLVVLQLEIDIDTVYYAIDFAAARGIPVLLNPAPGVPDLDFARLAKLEFLVPNETELALVSGMPTDTPDAVERAAGSLVERGVKHVIVTLGEKGSLLVSRAGAVRVPPVAVDARDTTGAGDAYIGCFARHYVATADIPAAMRLASAYAAHSVTGLGTQKSYADAATFERFLQTIGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M63</accession>
    <name>Q63M63_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110808.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0798"/>
    <dbReference type="EnsemblBacteria" id="CAH38259">
        <property type="protein sequence ID" value="CAH38259"/>
        <property type="gene ID" value="BPSS0798"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0798"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4874"/>
    <dbReference type="eggNOG" id="ENOG50317G8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17387" checksum="6456E1D4FBBDFA84" modified="2004-10-25" version="1">MRDPRRNATSPSGGFMSGEKTPTRRVLAVLLVFRWLPVRWRTPRLCLWLLSHGPLPIDPCLPPLAWAQRCVQRGDAVIRRRGRRATEPGDLQARSVYGSAVALGYYDLADVASPRTLQPVADSTWTREQLERLRQIGVGHGAALREYAGDYFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M78</accession>
    <name>Q63M78_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205462.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110793.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0784"/>
    <dbReference type="ESTHER" id="burma-q62d41">
        <property type="family name" value="Tannase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38244">
        <property type="protein sequence ID" value="CAH38244"/>
        <property type="gene ID" value="BPSS0784"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0784"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7036"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LTPMAKN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="PTHR33938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266582" evidence="6">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="574" mass="59546" checksum="F6E235CA75CF8400" modified="2004-10-25" version="1">MRFMQIMRRARMLAPLAFAALQACGGDGVDPALPRLAAAAPAAMSGTCGALAAKLRYPRTAFTSVATAAAGALSVAGKPVGEHCVIAGKMNERVSAIDGETYAIGFEMRLPKAWNGRFFYQANGGLDGDVVAATGDIGGGGPLDNALRMGFAVISSDAGHSAAQNPLFGIDPDARLDYGYRAVDALTPMAKQVIRLAYGKAPDRSYFGGCSNGGRHAMVAAVRNAGDYDGIVAGDPGLHLPKAAIAEMAGAQQFARIATATAAAGRPDIRSGFTDTERRFVASRILAKCDALDSVADGLVEDIAACQARFDLNADVPGCTNGVRTSQCLTGAQKTALANVFAGARNSAGEALYASFPFDAGVSGDNWAAWKQGNAMTLDPAAAAFTFTTPPRRPSALADLGAYALGFDMDRDAPAIFATSGVYAASAWSFMTPPDEADLSALKRRGGKLIVYHGTSDPVFSSTDTTDWYVRVMQANGGDASDFARFFRVAGMNHCSGGPAADQFDMLTPLVAWVEAGKAPDAIVATARDASNAAPNPEVPASWGAARTRPLCPYPRVARYDGGDVNAAASFSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M91</accession>
    <name>Q63M91_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205460.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110780.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0769"/>
    <dbReference type="ESTHER" id="burma-q62d56">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38229">
        <property type="protein sequence ID" value="CAH38229"/>
        <property type="gene ID" value="BPSS0769"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0769"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7012"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MYPVISM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266158" evidence="2">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="101"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="326" mass="34408" checksum="ED6A1AD4EE194148" modified="2004-10-25" version="1">MDITRRSLLGAALAGALDTIAPAAHAQAAARGAAPPDDAPRAVPDETIPLWPGPAPDPAPTGAGDGERIGRRGSVSRVARPRLNVYRPVHGNGGAALVIAGGGYDHIELGNESAPMCAWLTSLGVMAFELVYRLPEQGWSRLAPLQDGQRAMRLIRARAKRDGVDPARIAIIGFSAGGHLAGMTAVEPDARRYASVDDADRESARPDLAALLYPVLTLMPPFDRTRTRLHVAGAHPAQADSEALSANLRVSARTPPTFLAHAFDDPIAPIDNSLLMASALRAARVSVELHAFQAGGHGWGMGKPGSAVHAWPALFEQWARLNRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MN5</accession>
    <name>Q63MN5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205436.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110636.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0615"/>
    <dbReference type="EnsemblBacteria" id="CAH38072">
        <property type="protein sequence ID" value="CAH38072"/>
        <property type="gene ID" value="BPSS0615"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0615"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6798"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMDTPGG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266166" evidence="5">
        <location>
            <begin position="38"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="6">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="504" mass="50708" checksum="D72F0A6C3575988B" modified="2004-10-25" version="1">MPRSSPRPPPARGKLPARLARAAVLIGLLLACAAAAAAAGAAAAARAPIVVIPVAGAIGPASADFVVRGLERAAREHAPLAIVQLDTPGGLDTSMRQIIKAIVASGVPVAAFVAPGGARAASAGTYIVYASHVAAMAPGTNLGAASPVQLGIGGQAPAGGRREPAGAPGAAGAGATDTESIETRKALHDAAAYIRGLAQLRGRNAEWAERAVREAVSLPANDALAQHVVDLLANDPADLAAKLDGRTIVTATGAHRLDTAQAPLETLEPDWRSRLLATIADPSVALVLVTLGMYGLFFEFANPGFVLPGVAGAISLLVGLFALQLLPISYAGLALVLLGIAFLIAETFLPTFGALGVGGIVAFAIGALMLIDTDVPGYGVPWPVIASLAAAGAILVFGVSGFALRARRRPVVTGAEAIVGSIGEVLDDGLVPDQPPQIGPSADPGAPLAPSAAGWARVHGERWRVASATPIAAGRRVRVTGRNGLTLTVAPLYDNVVPPRGEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N38</accession>
    <name>Q63N38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative copper-resistance membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009932959.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110481.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0459"/>
    <dbReference type="EnsemblBacteria" id="CAH37915">
        <property type="protein sequence ID" value="CAH37915"/>
        <property type="gene ID" value="BPSS0459"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0459"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6606"/>
    <dbReference type="eggNOG" id="COG1276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PVWVDWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="314" mass="32694" checksum="BBD85FDF00A35E16" modified="2004-10-25" version="1">MNDGFLGMVRLAGVALQSVCFAIAVGVLLGDQWLARAASPWQAQVGRRLARTLRLAALGMLLSSMLAFWVHCALMSETALWDAWPAVRSMLAGTGYGRAWLAGAALMLAVVGLSFARSGGDARVPFALWLALAGVALARSNGGHPVDAGLFSAPVWIDWLHLLAISAWVGLVIVATYVVVPRLADARGGERRNGAAFVQSLSDAATFALVVLLSTGAYNGWRGVGAPANLIGSAYGQVLLLKLGLVAFAAALGGHNRFFEMPALLAAFKAPPDARAFVRSLRRFGVVLQVESVVLLGVIAAAAVLASSPLPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N86</accession>
    <name>Q63N86_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110433.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0410"/>
    <dbReference type="EnsemblBacteria" id="CAH37865">
        <property type="protein sequence ID" value="CAH37865"/>
        <property type="gene ID" value="BPSS0410"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0410"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4400"/>
    <dbReference type="eggNOG" id="ENOG502Z90A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SGLGWYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1192" mass="126671" checksum="47B27DAE7E390DCD" modified="2004-10-25" version="1">MRGDLMSFFTQFEGSRLYIGPVASGDAGWLAYLLPRPSPSTEEIDLDLALKQLPGSFLFSFTAPLLSTTPLLDAFIGAVDQVIARSPADRGFLWLMDPTAPTISSVPLMGIAADGSYVSNALQAPIFETLSLNVRAGVTLQLDGDTLRLGTANGIFFSGASAPGAPQASQIPAGTLPLSGAARGCIRFPVFLQRQFLHDGWNWGFQFQIPHDDPVRSAIGEWLPLAFGHLPNPGDMLGFDASYDPSDPWNAHAIAADRSVLVFTGQNQDGTATVLSSCYATTYGELLTLAPVAGPLDMQPDAARFLFNAGAPDDKGNHDFQIAPEGDFVIHAHGPSDGGTYDLICGLQGTEFVAFQPFVDGGYAGDRLRFTARSPAYAPRYPFTEVSPVGAPVDVNAPLLDATYTSSWGTVARAPGAPGAAAYVAQPKGAALYGRDALIHSLGEKTLFGPMTPSVTLPSSAFPMVPYAGASAGDGVTALTAERMADFERQVVSPTRRRRIADGGAGVASSKAHALKLADMATATPYNTTTPSGLLVTVDAAGQWSKILLGQNLSPTLRQMSFCNPGAELQQAFATSDLFLVTANAAHLGAFSADGSGACGPSATFANRINVGDWSFEAAVGQNNRYDDYADVMIVKGRRGPLWDPQNPAASLVASPDMWTQKDAFAAPSDLVPNPAPPPDETVAAPNPDELIALSYWLQRYFQDALDQAEPEYFAKFNTIAKDPAWTGILFLRMKISSIPDDLVGIVAGVQAPELFNAHHFGIEISQIANDPAAPDIALTTSSSMFGLIYYVDPAYIAPPPGIDPRPVPPTAGTDYQFRVLTLKALFENTAVQRFQSYAQLTLNSLFDMPVVSMGEGGNPYATLVLRGSYQDNGGRAVYSLGTTATSTFYFDNNLFTKIEVDSAQMSTRDSGANGQIVSWFALSGFLDFAVVQANDSSGAFDILSFGSHAGEDQLRRGLAYSNLGVRMTFPVADPATIAFAFSASEIRFDMQTSTPRPDSLFVNFALGLQGLVQGSAQTSPEADGFLNVVTDATLTGVNGDRWYGLAYQLNMGTPGNLAGTIGLTSGLLTAWAPVSADAGRYRASLGIQLPGTGGGANLISLQNVLRLSIGQMWLTYDRDKRSFLLMLTEIALKFMGLLKIPPSGSTLFYLFGNPQSEGKASGLGWYAMYNNTPASRSKSARLLGKARGWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB4</accession>
    <name>Q63NB4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552321.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110405.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0383"/>
    <dbReference type="EnsemblBacteria" id="CAH37833">
        <property type="protein sequence ID" value="CAH37833"/>
        <property type="gene ID" value="BPSS0383"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0383"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6510"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IKERTFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010260">
        <property type="entry name" value="AlpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05930">
        <property type="entry name" value="Phage_AlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="72" mass="7985" checksum="98A7788590258D61" modified="2004-10-25" version="1">MTVQFQATAIQPRRIVRMPALLERVGLSESEVRRRIKAGTFPRPVKLGPRAIGFVVADVDAWLEALTTRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NG4</accession>
    <name>Q63NG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205391.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110355.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0335"/>
    <dbReference type="EnsemblBacteria" id="CAH37783">
        <property type="protein sequence ID" value="CAH37783"/>
        <property type="gene ID" value="BPSS0335"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0335"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6454"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDRVACG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017224">
        <property type="entry name" value="Opine_Oxase_asu/HCN_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037495">
        <property type="entry name" value="Opine_OX_OoxA/HcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="44268" checksum="FB577B180B2C5952" modified="2004-10-25" version="1">MTNEILTVDVAIVGAGPAGLAAARAAARSGCTVAIVDDNPRAGGQVWRHGPHAAPGALARASFGVLRQPNVRHLAAARVVAAPRPGALLVEDEQRALVLGYRKLILCCGARELLLPFAGWTLPGVTGAGGLQALVKGGAPVRGERVVIAGSGPLLIASLATARAAGARVVALVEQAPPGALARFALSLAATPSKLAQAARLTRGFVGTRYLTGAVVREAHGDARVRAVTIEQGGARETLDCERLACGFGLVPNLTLALALGCAVRERAIAVDDAQRTSVEHVYAAGECTGVGGVELARIEGELAGLAAGGAHAAPHGRARMAALLRRRARWRRFAARVARTFALRDAARALPPDDTLLCRCEDVTIGAVRAHASARDAKLLTRCAMGACQGRVCGAAAHAYFGWDDAPPRPPFSPARIDTLLAASDDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NK4</accession>
    <name>Q63NK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529840.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110315.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0295"/>
    <dbReference type="EnsemblBacteria" id="CAH37743">
        <property type="protein sequence ID" value="CAH37743"/>
        <property type="gene ID" value="BPSS0295"/>
    </dbReference>
    <dbReference type="GeneID" id="56531245"/>
    <dbReference type="KEGG" id="bps:BPSS0295"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6400"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPVPCYN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="413" mass="42868" checksum="FE71F8D4A7F1A1C4" modified="2004-10-25" version="1">MTLANKKISLPLQMILGLALGVVFGLLAPAASRDLAFISTLFGHAIKMVVLPLILLSVTLGAFRAGTQRGRLGKTAAFSLVFFVLMTVIAAALGLALNWLFRPGIGASHAQTASMPANLASGIDWMKFLTDMIPSNIVGALAAGNSLPVLVFGVLLGCALAAVEDRAAPFVAVCESMLAAFFKMTEWVVSLSPIAIFAAIAVLLSSKGLAAMAPLAKLLGIAYLGMALLAAWLTLIVKLAGHSPRAVVRKVSEPLILGFTTRSSEITFPVHLKKLTEMGVPSSVASTVLPLSYIFNREGAVLYTVLAVCYLADAYQLAWSWPLMITIAVLTIITIDGAANVPSGAVVAITVILAAIGLPADAVLLILGVDAFFDMGRTALNVYASTVATTLASRVSGAAPEIAQATTAHASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NQ1</accession>
    <name>Q63NQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system, substrate-binding exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202259.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110268.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0249"/>
    <dbReference type="EnsemblBacteria" id="CAH37695">
        <property type="protein sequence ID" value="CAH37695"/>
        <property type="gene ID" value="BPSS0249"/>
    </dbReference>
    <dbReference type="GeneID" id="56597001"/>
    <dbReference type="KEGG" id="bps:BPSS0249"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6336"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVVWDFN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267015" evidence="1">
        <location>
            <begin position="32"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="38734" checksum="7D8630086669E30E" modified="2004-10-25" version="1">MSENRPLLTALRRAALAFGMCATLVANGASAEPLYAGEDALYAKAADEGLVVSFDTGPEWANWKALFAAFRKRYPKVELTYNDIGSAATVVALDKSRRRPQADTAYYFAASALDAAGKDVVAPFKPVNFDKLPPVFREADGRWFTVHSLNVAFLVNRKLVKNVPRRWSDLLKPEYRNAVVYLDPRSTGQGQVVVFAAASALGGGVDDPKPGAEFFGKLKHAGNVLRIEGTTPYAKFVKGEIPILIGYENDGLKAKYADGLGDAVDVVIPQDGSVCAPYAMSLVKNGPNPAAAQLWLNFVMSDAGQALFAHGYVRPAVPGVALAPDVAAKMPNAPQVRALDVAKAAARKAEVDRLWSQAALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NS0</accession>
    <name>Q63NS0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188641.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110249.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0229"/>
    <dbReference type="EnsemblBacteria" id="CAH37674">
        <property type="protein sequence ID" value="CAH37674"/>
        <property type="gene ID" value="BPSS0229"/>
    </dbReference>
    <dbReference type="GeneID" id="56596981"/>
    <dbReference type="KEGG" id="bps:BPSS0229"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6307"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYDWLNG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005698783" evidence="1">
        <location>
            <begin position="28"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="553" mass="58032" checksum="63CB519C5C76858D" modified="2004-10-25" version="1">MKRNSKQFEIGAWLGACALAFAGAASAAAVQDRDHDSRPVDAKRVLLVSIDGLHEQDLARCIGANTCPNLALLAKSGVTYTNARTPGLSDSFPGLAALVTGGSPKSAGLFYDVSYDRTLYAPSDATCSGKQGWNVVFDETTGIDAMNGGALTHLDGGGAFNPQAIPHARVNGQCVSVYPHDYVKTNTVFEVVKEHLRGSHTAWADKHAWGYDWVNGPSGKGVDDLARTEINSIDPATGTPYTDIYTHTEKFDDYHVQAIVNQIDGKNSTGTAAAPVPTLFGTNFQTLSVAQKATVASGGGYLDASFTPGPEVANAIAYVDGALGRIVAELRQRGLYDSTVVIVTAKHGQSPTDHTKLVKHGDTLTALLEANGFVDPNGNFGQNNTASGNPNDGTGLVGTGFVQTDDVGLVWLRDPRQLSAAVATLKANLGCNAPGICADGPQAYILYGPSVAERFGDPALGRTPDIVVQPNPGVIYTSSKKKDEEHGGNAPDDSHLGLLVSYAGLRQGRTIDAPVLTTQVAPTILRSLGLEPRLLHAVALEGTRVLPGLGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NS9</accession>
    <name>Q63NS9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110240.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37665">
        <property type="protein sequence ID" value="CAH37665"/>
        <property type="gene ID" value="BPSS0220"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0220"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4171"/>
    <dbReference type="eggNOG" id="ENOG50316Q2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMRRVNR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="426" mass="43064" checksum="4F4DB318DAA0C591" modified="2004-10-25" version="1">MAVDETAHDAARVQARGFGGLDRPRRDAGAGAGADAGAGAGAGADADASADASADADADARGARAAAHAPEPAGEQADLLSGFGESPAADRQDAQRNADGRVDAEAADGERSRAVKADERLNEGVSQGVNAEASAGEHAAAGPAIIRRGASAPDASEPAAAKSGVDEATAARPPRARRASARRADGGKQAAERGARRGRAAEGAISKSAGADGGALGGEAAGGQAAENRAVPADTVRDSSPAPVARRDAAVRGRPAEARALPAAADRAPVNAAQPHPRSANPSPALLPAAAAQAATSAASADSDAQLRPLADRIRALQSETIDLRRAADAQMRRVNRLLLALAVVLLAAIVAWIVQAVQLSRQRDQFAAMQQRIDRLVAAQATQGATIATLSQRQDEVGAQVDRLTSRLSSAAVPAKRAHRTRHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NT5</accession>
    <name>Q63NT5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative heme/metallo cofactor biosynthesis related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200682.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110234.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0214"/>
    <dbReference type="EnsemblBacteria" id="CAH37659">
        <property type="protein sequence ID" value="CAH37659"/>
        <property type="gene ID" value="BPSS0214"/>
    </dbReference>
    <dbReference type="GeneID" id="56596967"/>
    <dbReference type="KEGG" id="bps:BPSS0214"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6285"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWGRQFF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023820">
        <property type="entry name" value="rSAM_GDL-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03913">
        <property type="entry name" value="rad_SAM_trio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="491" mass="53737" checksum="003B7766C187203B" modified="2004-10-25" version="1">MSTTDARPARYLFDSDYQRFVPVHAVWEITLACDLKCLHCGSRAGHRRTNELSTAECLEVIDALARLGTREVSLIGGEAYLRKDWTQLIRAIRSHGMYCAIQTGGRNLTPKRLAQAVDAGLNGVGVSLDGLAPLHDKVRNVPGAFERALDTLRRARDAGIAVSVNTQIGAQTMEDLPALMDTIIELGATHWQIQLTVAMGNAVDNDELLLQPYRLAELMPLLAKLYKDGVSRGLLMTVGNNIGYYGPYEHLWRGFGDERVHWSGCAAGQNVIALEADGTVKGCPSLATVGFSGGNVRDMSLEDIWRTSEGIHFGRLRSVDDLWGFCRTCYYADVCRGGCTWTSHSLLGKPGNNPYCHYRVLELQKQGLRERIAKVQDAGPASFAVGRFDLVTERIADGEPVASVVRSGQVIELAWKNRGKRSPEVGRVPPKLKMCRNCDGYVHAGEQTCPHCGGDIDAAARAHELDAQRRHALMNDLERLLGLPASTFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NW1</accession>
    <name>Q63NW1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523537.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110208.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0187"/>
    <dbReference type="EnsemblBacteria" id="CAH37632">
        <property type="protein sequence ID" value="CAH37632"/>
        <property type="gene ID" value="BPSS0187"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0187"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6252"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICSPLDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="32563" checksum="CF3AA30540BCF2C5" modified="2004-10-25" version="1">MDNLRRLDLNLLITLDALLSEHNVTRAAARLNLSQPSVSIHLAKLRDIFGDPLLLPGPRGMRPTARADELREPLRRALETLGRAVSPGAPFDPAASAHTWRVAASDYSESTVVLPALNGLRAAAPGTRLAVVETVPSRIAKQAEQGDIDLAFHITECAPGNLRHRALFTERYVLVGRAGHPRLKRRPTLAQFCKLDHVIVSPDGGGFQGGTDHALAKLGLARRVVLSVPHFLFMMSAVANSDLVAMMPSRLVRDSRALQVVEPPVDVPGFRMAMLWHERSHRDPAHQWLREHIAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P31</accession>
    <name>Q63P31_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS0117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205345.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110138.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0117"/>
    <dbReference type="EnsemblBacteria" id="CAH37562">
        <property type="protein sequence ID" value="CAH37562"/>
        <property type="gene ID" value="BPSS0117"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0117"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6151"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWNRRIE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="539"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="787"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="924"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="836"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="4">
        <location>
            <position position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110806" checksum="549F6E6326AF3D35" modified="2004-10-25" version="1">MPGKLKELLIQPFKLNHRKALFDPRRMLAHQRLLTYGGAIGISAFILFCLLLMIRMEAMDYVSNARSEFLIQQSKLTIKLQIRRTALMRAVMHAEGLWNRRIEPSTELLSQFDAHQGYAVLHTPQGAPAALAVGIPAPGRSASAFAPYLALLETQLLMGDGQSPLPDDRVEGYSFSPDGTYLSLLWSREDQAPEAFIESHSASGLIGDAMRGIRYLRDASTIVPLRADRRTVWLPPHPDPLTGKPMIRIVQPAIDATGKLFAIYVRSLPLDMFYSNLNDAPAGSTLTIVDRKGNVILGSSNQHGGDGGATASALGIRSLGDGFGGLVERYQDGMFVTSDQLPGTDWVLVHAYSWKTIAAALALRFSLVTGLVAGIIVMLWLFAIQFDRKGLIPNYRRAQRLLESEVLNRTILRTAPVGLGLLSAQDGSVLLQNNAMLELSARTSDEPLPIRLWEAYRHAVGRSSDEDGALLQHDLAIEREGANPVYLQANVVAARYRGANVLLCTLLDISLRKESELKLKEARIAADQANKAKSTFLATMSHEIRTPLNAIIGNLELLRRSPLSEQQSERLHVVESCSNALLHIINDILDLSKVESGQMTLENIPFDIHALLQETVDAYAPLAESKGLALLSSIGEGVARHYAGDPTRIRQVLSNLIGNAIKFTERGHISIDVHRAKAARDGSAIEIWVNDTGIGIRPDRIATLFDVYTQADASIHRRFGGSGLGLPLCQRLVTIMGGSIEIDSLPDFGTTVTVALPLREARHATALSNGPAARRRNATALARPTLHVLVAEDHPANRALLRDQLEALDHRVDVVENGREALRAFGEHQYDIVLTDLGMPELDGYGFARFANKMRAGTPIVAMTAHATDEDYQRSKKVGIAEIVLKPLSLTTLEKVLQRHAMRAPAEEIVTAAGPGPAHAEPRMRALPPAVAAALRTATLQSIDKIAQALAARNFETIRQELHSIKGGFALTGNRLLIARCAATEELAEAEDLDTLRAAWRKLEASLLEALERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P33</accession>
    <name>Q63P33_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205344.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110136.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0115"/>
    <dbReference type="EnsemblBacteria" id="CAH37560">
        <property type="protein sequence ID" value="CAH37560"/>
        <property type="gene ID" value="BPSS0115"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0115"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6144"/>
    <dbReference type="eggNOG" id="ENOG503171U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMENHCA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="38065" checksum="AC082425767A9276" modified="2004-10-25" version="1">MSKNGSPLKSDRSRHASAHHEAPDVPTPLVSLARYEGRDASPPRQHAIGAAGCVYFVQANRFEAWDARIGIPNDGIIFAAEPDGSLRMENHCARADCRVNGEAVAPGACRHLERGDVIAVAAAELTIQDGASAREPSAPRQPPVDLIALGNALPRSEPAHFADLAELANLPAAAHPHGRASAGAAAPLVILDEEALSDAAPPAFDSTNHDPLAHLLTEYRRALIHQERSYAHALKSIERPQIAVPLPDDPFLDAPGRYRRGSLLGDLLGSRQNIDYVLDEMNPFRAEALFADEARHDVLLLLAPRRRKKAHFPQTALLARHEHHLMSVDSHFPTLGAETDIQQEEPNDESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P69</accession>
    <name>Q63P69_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative HNS-like regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BPSS0077A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528499.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110100.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0077A"/>
    <dbReference type="EnsemblBacteria" id="CAH37522">
        <property type="protein sequence ID" value="CAH37522"/>
        <property type="gene ID" value="BPSS0077A"/>
    </dbReference>
    <dbReference type="GeneID" id="56530374"/>
    <dbReference type="KEGG" id="bps:BPSS0077A"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3994"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PKYREPA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="6">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="11670" checksum="9C6E488E186B13EA" modified="2004-10-25" version="1">MATYEELKAQLDALNKEAEAAKAREISTALSQIRETVLRYEIRPDQIFPQWTRLRSPDKRRGPLPPKYRNPMTGETWCGRGRAPKWMSGSPREAFLIDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PH2</accession>
    <name>Q63PH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109997.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63PH2"/>
    <dbReference type="STRING" id="272560.BPSL3404"/>
    <dbReference type="EnsemblBacteria" id="CAH37416">
        <property type="protein sequence ID" value="CAH37416"/>
        <property type="gene ID" value="BPSL3404"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3404"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3873"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IAMFIDV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="383" mass="40972" checksum="89E000F617CFAA45" modified="2004-10-25" version="1">MPLDRAVSNSVVGRAPARIIAFVRHEPVLSILVAALIALQAVHSLSAIALVRLVDWQTVATLAGLLMLTKALELSGFLMWLAHRIVHRVRSERALAALLVVFAAALSVWLTNDVALFVVIPLVLSLRELTPLPFKRLVIYIALAVNAGAIATPLGNPQNLFLWQLSGVSFGRFVIALGPLALVLMALLLAMVVFAFDGRPLDLSRDSTERPVDRAQAFATVAMFAGFVLLADAHHALAGVLAVAAVFLIVRRDAVLKIDWLLLLIFVLMFIVLRSAASLPAVHQAIAGIGLDTPLRAYAAGALLSQIISNVPAAILLSEFTHDWRALAFGVSVGGFGIAFGSLANLIAIRLSRARGMWLPFHLASIPFGIASAVLGALLLHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PJ5</accession>
    <name>Q63PJ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PadR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200072.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109974.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3380"/>
    <dbReference type="EnsemblBacteria" id="CAH37392">
        <property type="protein sequence ID" value="CAH37392"/>
        <property type="gene ID" value="BPSL3380"/>
    </dbReference>
    <dbReference type="GeneID" id="56593878"/>
    <dbReference type="KEGG" id="bps:BPSL3380"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1816"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MHPYELG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="213" mass="24061" checksum="5C89D83936941B3E" modified="2004-10-25" version="1">MAQSASRYSPLALIVLAMLTEAPMHAYRIQQLVKLRGKDEVVNVKQRNSLYQTIERLQRDALIAVRETERDGAFPERTVYEVTDAGRDTARMWLREQLARPAREYPSFPAALSVLPLLSVEDARRQFEARVAALEAELARLDETQNAALAMQIPRLFLLDGELMRVTLEAELDWVRSVIGHLKVGALTWSEAWLREVAARFAQADSPDSADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PW5</accession>
    <name>Q63PW5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative plasmid recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109853.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3257"/>
    <dbReference type="EnsemblBacteria" id="CAH37270">
        <property type="protein sequence ID" value="CAH37270"/>
        <property type="gene ID" value="BPSL3257"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3257"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMRYYHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="137"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="333" mass="37582" checksum="EAC76F846FC36635" modified="2004-10-25" version="1">MSRGVWVSRSEAEATTLYEALERYEEEISATKKGAVQEQSVLKSCKALDLAKRPLASIRSSDIAALRDEWLKSYKPATVLRRLAVLSHVFNIARKEWGMESLSNPVELVRKPQPNNARTRRVATTDLSPSSKKDDEPESERGAEDGEIELALAASNSELLPAIVWLATETAMRRSEIVSLQWQHVDLKRRVAHLPATKNGDARDVPLSPRAVAVLQALRDTQASAGKKTLEHDEIARADRVFTIRADAVTRAFERAVARARAKYLDICKEAGRRPNPKFLTDLRFHDLRHEATSRLASIFPLHELTKITGHKDPRMLMRYYHPKAEDLAKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QA2</accession>
    <name>Q63QA2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Ubiquinol-cytochrome c reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="4 17">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">petA</name>
        <name evidence="20" type="ordered locus">BPSL3123</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="17">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 18">The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="17">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="4 17"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109716.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3123"/>
    <dbReference type="EnsemblBacteria" id="CAH37133">
        <property type="protein sequence ID" value="CAH37133"/>
        <property type="gene ID" value="BPSL3123"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3123"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3572"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRTWLIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019470">
        <property type="entry name" value="Ubiq_cytC_Rdtase_Fe-S_su_TAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10399">
        <property type="entry name" value="UCR_Fe-S_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="19">
        <location>
            <begin position="90"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAH37133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="22252" checksum="F17CEBA21902CA8A" modified="2004-10-25" version="1">MMRDKEEEHVDSGRRTWLIATSVAGGVGGVATVIPFAASLAPSTKAKAAGAPVEVDIGALKPGEMLTVPWRGKPVWVLNRTDAMLADVVKADKEVADPQSKSPYSMPLPEYCANEYRSRADRKNILVVMAVCTHLGCTPSQRFTPGPQPNLPDDWPGGFLCPCHGSTYDLAGRVFKNKPAPQNLDVPPYMFTSATTLVIGKDEKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QE5</accession>
    <name>Q63QE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL3078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527813.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109673.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3078"/>
    <dbReference type="EnsemblBacteria" id="CAH37089">
        <property type="protein sequence ID" value="CAH37089"/>
        <property type="gene ID" value="BPSL3078"/>
    </dbReference>
    <dbReference type="GeneID" id="56528109"/>
    <dbReference type="KEGG" id="bps:BPSL3078"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2176"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HKAFGIH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="533" mass="57864" checksum="738CC753EA1BAF63" modified="2004-10-25" version="1">MKSSIQRNIGPFALMLTGLGSIIGSGWLFGAWKAAKIAGPAAICAWIIGAVVILAIALTYAELGAMFPESGGMVRYARYSHGSLVGFISAWANWIAIVSVIPIEAEASIQYMSTWPYAWAHALFVNGELTTPGLLLSAILVVIYFLLNYWGVKLFARANTAITIFKFLIPGLTIAGLLLSSFHSENLGTAGGSSGFAPYGWSAVLTAVATSGIVFAFNGFQSPVNLAGEARNPSRSVPFAVISSILIALVIYVLLQVAYIGAVNPADVAKGWAHFNFASPFAELAIALNLNWLAILLYVDAFVSPSGTGTTYMATTTRMIYAMERNNTMPKIFGSVHPLYGVPRPAMWFNLMVSFVFLFFFRGWSSLAAVISVATVISYLTGPISLMALRRAATDLERPLAIPCMKLIAPFAFVCASLILYWAKWPLTGEIILLMIVALPVYFYYQGKAGWSGWGRDLKAAWWLVAYLPTMAVLSLIGSKEFGGHGVLPYGWDMLVVAAIALVFYYWGVHTGYRTEYLDERESRDEILEGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU2</accession>
    <name>Q63QU2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphogluconate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">edd</name>
        <name evidence="7" type="ordered locus">BPSL2932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="4.2.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.12" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527741.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109526.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2932"/>
    <dbReference type="EnsemblBacteria" id="CAH36942">
        <property type="protein sequence ID" value="CAH36942"/>
        <property type="gene ID" value="BPSL2932"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2932"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2349"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CANIAHV"/>
    <dbReference type="UniPathway" id="UPA00226"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004456">
        <property type="term" value="F:phosphogluconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046177">
        <property type="term" value="P:D-gluconate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009255">
        <property type="term" value="P:Entner-Doudoroff pathway through 6-phosphogluconate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02094">
        <property type="entry name" value="Edd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004786">
        <property type="entry name" value="6-phosphgluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43661:SF1">
        <property type="entry name" value="PTHR43661:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01196">
        <property type="entry name" value="edd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="617" mass="64669" checksum="CFA702714EE71B31" modified="2004-10-25" version="1">MATLHPTLASVTERVIARSRPTRQAYLARIDAAQGHFPARSALSCANLAHGFAGLEGSDKFAIKAIREPNIGIVSAYNEMLSAHAPYKGFPDIIKAAARERGGVAQFAGGVPAMCDGVTQGNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMEVMGLHLPSAAFVHPHTPLRDALTAEAARRVLELTAERGQYTPIGHVIDERAIVNGIVALLATGGSTNHTLHLVAIARAAGILIDWDDFDALSAAVPLLAKIYPNGKADVNHFHAAGGIAFLVRNLLEGGLLHEDVTTVAGKGLAHYTKEPRLIDGKLTWVDGVGESADDKVLRPIAAPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQGARANGMPELHRLTPLLGVLQDQGFRVALVTDGRMSGASGKVPAVIHVSPEALLSGPLGKVCTGDTIVIDAQAGVLDVEIDEQAWAARAVAQPAHQAENEVGFGRELFGVFRAAAAPAEQGASVFGASVGEAAHVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV5</accession>
    <name>Q63QV5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="5" type="synonym">groES2</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">BPSL2919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194371.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109513.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2919"/>
    <dbReference type="EnsemblBacteria" id="CAH36929">
        <property type="protein sequence ID" value="CAH36929"/>
        <property type="gene ID" value="BPSL2919"/>
    </dbReference>
    <dbReference type="GeneID" id="56593756"/>
    <dbReference type="KEGG" id="bps:BPSL2919"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2365"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KVFYRQW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="11455" checksum="E0CCDDEBC357BEBF" modified="2004-10-25" version="1">MHVRPLYDRVIVKRIEQQRTTASGIVIPDSAAEKPEQGEIVALGNGRLLQDGTLRALQLEVGDQVIFGEYAGQSIKVDGEDFLVIREEDVLGVLEAGERAARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R03</accession>
    <name>Q63R03_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">secD</name>
        <name evidence="12" type="ordered locus">BPSL2871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550004.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109465.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2871"/>
    <dbReference type="EnsemblBacteria" id="CAH36881">
        <property type="protein sequence ID" value="CAH36881"/>
        <property type="gene ID" value="BPSL2871"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2871"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2425"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027398">
        <property type="entry name" value="SecD-TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13721">
        <property type="entry name" value="SecD-TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="SecD-TM1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="621"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="674" mass="71794" checksum="E202F92F0DFAAC20" modified="2004-10-25" version="1">MNRYPIWKYVVMVVALAIGFLYTLPNFFGEAPAVQVSSGKATVKLGADTLAQVEAALKANQVAADDVTFDNSSANATIRVRLKDTDTQLRVKDMLQKTLNADPNDPQYVVALNLQSASPRWLTALHALPMYLGLDLRGGVHFLLQVDMTGALTKKLDSDASDARTQLRDKGIRDGGVARVDQTVVANFADQDTAEQARKLLASSVSELQWATQPGGGGYQVVGTFTPAVQKAVEEAALKQNLTTLHNRVNELGVSEPILQQQGNDRIVVELPGVQDTAKAKDIIGRTATLEARLADPLNTHPNPNDPVPPGEELFTQGNQAPVLLKKQVIFTGDRIIDASAGFDEHQRPSVNIRLDSAGGRAVRAVSRENIGKPMAMVLFEKGKGEVLTVATIQSELGDRFQITGQPTPQAAADLALLLRAGSLAAPMDIIEERTIGPSLGADNIRMGFHSVIWGFVAIAVFMIAYYMLFGVVSVLGLSVNLLLLVAVLSLMQATLTLPGIAAIALALGMAIDSNVLINERIREELRRGASPQIAIQEGYAHAWATILDSNVTTLIAGLALLAFGSGPVRAFAIVHCLGILTSMFSAVFFSRGLVNLWYGGRKKLQSLAIGQVWRPAAEAGTAPQLGQDARANAPQPGARVAAPKQPAGAPRTGKPVARRRSGPGVPPKQGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R04</accession>
    <name>Q63R04_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Sec translocon accessory complex subunit YajC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yajC</name>
        <name evidence="11" type="ordered locus">BPSL2870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194088.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109464.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2870"/>
    <dbReference type="EnsemblBacteria" id="CAH36880">
        <property type="protein sequence ID" value="CAH36880"/>
        <property type="gene ID" value="BPSL2870"/>
    </dbReference>
    <dbReference type="GeneID" id="56593716"/>
    <dbReference type="KEGG" id="bps:BPSL2870"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2426"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMEMIIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="11535" checksum="700B036CF5ECF5C7" modified="2004-10-25" version="1">MSFIPNAYAQGAAGGAESSLMSFLPLILMFAVLYFIMIRPQMKRQKEHRNMLAAMAKGDEVVTSGGLVGKVTKVSEAYIGVEIAEGTEITVQKAAVTTILPKGTIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R10</accession>
    <name>Q63R10_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109458.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2864"/>
    <dbReference type="EnsemblBacteria" id="CAH36874">
        <property type="protein sequence ID" value="CAH36874"/>
        <property type="gene ID" value="BPSL2864"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2864"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3267"/>
    <dbReference type="OMA" id="MILEMRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="57" mass="5655" checksum="85B475318B20C2C9" modified="2004-10-25" version="1">MTIMTQMILDLRGALAAPARRAGAAAWRRLIGLAIAGGGAAVLAAQAARYFTAAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R80</accession>
    <name>Q63R80_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">wcbN</name>
        <name evidence="10" type="ordered locus">BPSL2793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194255.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109388.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63R80"/>
    <dbReference type="STRING" id="272560.BPSL2793"/>
    <dbReference type="EnsemblBacteria" id="CAH36802">
        <property type="protein sequence ID" value="CAH36802"/>
        <property type="gene ID" value="BPSL2793"/>
    </dbReference>
    <dbReference type="GeneID" id="56594717"/>
    <dbReference type="KEGG" id="bps:BPSL2793"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2515"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHPMRKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00213">
        <property type="entry name" value="GmhB_yaeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="8">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="189" mass="20428" checksum="C176C93FCE0144B4" modified="2004-10-25" version="1">MKNRALFLDRDGVINRDDGYVFEIEKFVFLDGIFELAGAAKALGYLSIVVTNQAGIGRGYYSEDDFFRLSDWMKGVFATEGAPIDGVYFCPTHPEHGIGRYKVESRFRKPNPGMILAAQHDFDLDLGASLLVGDKESDIQAGSTAGVGTTLLICDRDASRVATAASAVVRNPRDVIPFLTGPGPDAGSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF6</accession>
    <name>HBOH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-(-)-3-hydroxybutyrate oligomer hydrolase</fullName>
            <shortName evidence="1">3HB-oligomer hydrolase</shortName>
            <shortName evidence="1">3HBOH</shortName>
            <ecNumber evidence="1">3.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL2716</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10172"/>
            <dbReference type="ChEBI" id="CHEBI:10979"/>
            <dbReference type="ChEBI" id="CHEBI:10983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="EC" id="3.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; butanoate metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532230.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109312.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RF6"/>
    <dbReference type="STRING" id="272560.BPSL2716"/>
    <dbReference type="ESTHER" id="burps-hboh">
        <property type="family name" value="OHBut_olig_hydro_put"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36724">
        <property type="protein sequence ID" value="CAH36724"/>
        <property type="gene ID" value="BPSL2716"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2716"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2613"/>
    <dbReference type="eggNOG" id="ENOG502Z8QU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPEKDWG"/>
    <dbReference type="UniPathway" id="UPA00863"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047989">
        <property type="term" value="F:hydroxybutyrate-dimer hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01906">
        <property type="entry name" value="3HBOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016582">
        <property type="entry name" value="OHBut_olig_hydro_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10605">
        <property type="entry name" value="3HBOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011409">
        <property type="entry name" value="HObutyrate_olig_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000314421" description="D-(-)-3-hydroxybutyrate oligomer hydrolase">
        <location>
            <begin position="34"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01906"/>
        </source>
    </evidence>
    <sequence length="699" mass="71678" checksum="4C965DFD48073390" modified="2004-10-25" version="1" precursor="true">MTAIRGGSRRAPGLALALLGGVLLGACHGDENAQVNALPGFVSGSVRKTAYDGASDDLLTAGLGKTGLGSDTRPGFANPAQPSAAELRRLAIYSNYRALVDITPNGGYGRFWGPNVDLAGNDTLGEGKIAGTEYLAYSDDGSGRKNVTLLVQVPASFDPANPCIVTATASGSRGVYGAIAAAGEWGLKRGCAVAYNDKGGGNGAHEIGTGVVTLIDGTLATASSAGSSSLFTASESSSTLAAFNSAFPNRYAYKHAHSQQNPEQDWGRVTLQAVEFAYWALNEQFGPVVDGTRHGIRYRPGDITTIAASVSNGGGSALAAAEQDTRGWITAVVVGEPQINVRMTPGVTVEQGGAPVPSFGRPLADYATLANLLQPCAAAAVAATGAPYLSALPMGVTQSIRTQRCATLAAAGLVSGADTASQASDALAQLHAAGYLADSDLLQAPMWDSQAMPAIAVTYANAYTRSRVTDNLCNFSFATTNPVTGAVAAPAVSPMTNLFGAGNGVPPTNGINLVFNGASGGVDHRLATPDASFAGAFCLRQLWTANQLGIGTNVDAVRVAANLQHKPAIIVHGRSDALVPVNHASRAYVAQNSATEGRASQLSFYEVTNGQHFDAFLSVPGFDTRFVPVHYYDEQALNLMWNHLKSGAPLPPSQVIRTVPRGGVPGAAPALSTANLPPIVQSPGANAIAVNAGVIDVPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RL6</accession>
    <name>URED_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureD</name>
        <name type="ordered locus">BPSL2656</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH36664" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36664.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185533.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109252.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RL6"/>
    <dbReference type="SMR" id="Q63RL6"/>
    <dbReference type="STRING" id="272560.BPSL2656"/>
    <dbReference type="EnsemblBacteria" id="CAH36664">
        <property type="protein sequence ID" value="CAH36664"/>
        <property type="gene ID" value="BPSL2656"/>
    </dbReference>
    <dbReference type="GeneID" id="56594816"/>
    <dbReference type="KEGG" id="bps:BPSL2656"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2689"/>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CQHIIVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0996">Nickel insertion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000340437" description="Urease accessory protein UreD">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="291" mass="30980" checksum="EA704623B8A72259" modified="2008-06-10" version="2">MSAHEPHTSLVRPAAKAWHARLELGFERQPGGRTALAHRRHVGPLRVQRALYPEGDAICHAVIVHPPGGVAGGDRLEIDVRLDAGTHAVLTTPGATKWYKSNGLDARQRIDIDVGAHAKLDWLPQNNLFFDAAHASLEFVLALGDGASVLGWDATQLGRQAAGEAWSAGSIASFSKIVGPSGRPLWVERARLDAGDPLRAAPQGLGGFAVYGTLWALGAACTEALAESIAPALPFDDALRAGVTCVAPGTLLIRALAHSMEALQRLLAEQWLALRPIVHGVDPKPLRLWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RM2</accession>
    <name>Q63RM2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938469.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109246.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2650"/>
    <dbReference type="EnsemblBacteria" id="CAH36658">
        <property type="protein sequence ID" value="CAH36658"/>
        <property type="gene ID" value="BPSL2650"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2650"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2696"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLVPYNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="442" mass="47457" checksum="0C268AB89586C085" modified="2004-10-25" version="1">MTEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAGHGRDEIVAAVQAQAEEMDFAPTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGIAPNRNAYSGALLPSVDHLPHTLNLKEAAFSKGQPAWGAQLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPRGYLERLRELCDKHGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTNNAAVPMGAVAASGAIHDAIVGGAPAGIELFHGYTYSGHPLAAAAAVATIDLYEREGLLTRAARIAPIFEREIHKLKDARHVIDVRNLGIVGGVELTPRDGKPGARAYEVFVKCFEKGAMIRYTGDILAFSPPLIVEEAQIVELFSIVAQALKETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S50</accession>
    <name>Q63S50_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54 interacting regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539908.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109067.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2474"/>
    <dbReference type="EnsemblBacteria" id="CAH36478">
        <property type="protein sequence ID" value="CAH36478"/>
        <property type="gene ID" value="BPSL2474"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2474"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2913"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGWHVEV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045343">
        <property type="entry name" value="VpsR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20161">
        <property type="entry name" value="VpsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="461" mass="51190" checksum="92FE93339437E339" modified="2004-10-25" version="1">MDVAARHLIYYSHRPDADLQRCFDQHGWQVDVVDSPREMRRSAARDVIAGGLLDFSCGIGAAELRELEASLKTPNVGWIATTRRGQMEDDAVRRLVRDYCFDYVTVPYECDRIVESVGHAYGMVTLSEGLAPAAATVRNEGEMVGTCEAMLALFKMIRKVASTDAPVFISGESGTGKELTAVAIHERSSRAGAPFVAINCGAIPPTLLQAELFGYERGAFTGANQRKIGRIEAANGGTLFLDEIGDLPFESQASLLRFLQEHKVERVGGHQSIPVDVRIISATHVDMQIALRNGRFREDLYHRLCVLKLEEPPLRERGKDIEILARHMLERFKGDAHRRLRGFTPDAIAALHNYAWPGNVRELINRVRRAIVMSEGRMISAADLELSGYAEVAPMSLEEARESAERHAIEVALLRHRGRLADAARELGVSRVTLYRLLCAYGMRDDGGARAKRDEGLRRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S73</accession>
    <name>Q63S73_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease E</fullName>
            <shortName evidence="5">RNase E</shortName>
            <ecNumber evidence="5">3.1.26.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rne</name>
        <name evidence="8" type="ordered locus">BPSL2452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.</text>
            <dbReference type="EC" id="3.1.26.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per homotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer formed by a dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase E/G family. RNase E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.12" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527470.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109044.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2452"/>
    <dbReference type="EnsemblBacteria" id="CAH36455">
        <property type="protein sequence ID" value="CAH36455"/>
        <property type="gene ID" value="BPSL2452"/>
    </dbReference>
    <dbReference type="GeneID" id="56528732"/>
    <dbReference type="KEGG" id="bps:BPSL2452"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2938"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPQYASK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008995">
        <property type="term" value="F:ribonuclease E activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00970">
        <property type="entry name" value="RNase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028878">
        <property type="entry name" value="RNase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for zinc-mediated homotetramerization and catalytic activity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117095" checksum="88A0B5E6DA9A563D" modified="2004-10-25" version="1">MKRMLFNATQQEELRVAIVDGQKLIDIDIETAGREQRKGNIYKGVVTRIEPSLEACFVNYGEDRHGFLPFKEVARQYFKEGVDMRSARIQDALREGQELIVQVEKEERGNKGAALTTFISLAGRYLVLMPNNPRGGGVSRRIEGDERQELRETMAQLQIPDGMSMIARTAGIGRSAEELQWDLNYLLQLWRAIEAASQSGHPGQPMLIYLESSLVIRAIRDYFQPDIGEILIDTTEIHDQARAFMDIVMPDNVGKVKRYHDDVPLFSRFQIEHQIETAYSRTVPLPSGGAIVIDHTEALVAIDVNSARATKGADIEETATRTNLEAADEVARQLRLRDLGGLIVIDFIDMESAKSQREVEQRLKDALKHDRARVQMGKISRFGLMELSRQRLRPALSEGSHVTCPRCNGTGHIRDTESSALQVLRIIQEEAMKENTAAIHCQVPVEVTAFLLNEKRQEINKIESRFKVGVVLIPNKHLDTPHYKLERLRHDDARLDDPRASWKMAEEAARELEAETGYSKRAEETKPRQEAAVKGITPERPAPSPAPQRQSAPEAAAPVAAAPASGGGFMKWLKGLFGAQPAAVPAPAPAAQETAARPARERAERGERGEKAERGERGGDRNRHRRGGAAQQAGGRDQAAAGGGRAQAPRAEREGKETREPREGREARGGRDNREGREARETREAREPREQREPREAREQREARERAETVDAAEAPRGERRERGERRKPAPHVATLETVNRGESAHAETAEKPLYAPGAEAGVDADSNARDGEERRRRRRGRRGGRREREDEVAGAVQAAEGSEGVTAEAEALEHAEHAQQRVAPVANQAPEHAAQAGAGVAAAAAATVAAEAIAHVESGAKVEPQPAAEASAGDTEQAEAVPARSIEAPAQAASTGQAEAVQAAPAAPAHVTPATADVAREPAAPAETASAETTPAEIPPAEAAPAEAPAAEASEVAASAVASAPAPAAEPAPAAEPHRPAPVSAAPASAAPAEADAAREPAAVAEPHVPAAAATPTPASVATTPGASLDTALAAAGLVWVNTDTDKLRAAQAAAAQIVQPVRVPRERKPLPPVDATPMQQVETTHR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S81</accession>
    <name>RL32_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmF</name>
        <name type="ordered locus">BPSL2444</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192741.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109036.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S81"/>
    <dbReference type="SMR" id="Q63S81"/>
    <dbReference type="STRING" id="272560.BPSL2444"/>
    <dbReference type="EnsemblBacteria" id="CAH36447">
        <property type="protein sequence ID" value="CAH36447"/>
        <property type="gene ID" value="BPSL2444"/>
    </dbReference>
    <dbReference type="GeneID" id="56596359"/>
    <dbReference type="KEGG" id="bps:BPSL2444"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2946"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMHRAHD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000225709" description="50S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="59" mass="6683" checksum="E66322DA547E3112" modified="2004-10-25" version="1">MAVQQNKKSPSKRGMHRSHDFLTTSPLAVEPSTGEVHLRHHISPNGYYRGKKVVKTKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SB8</accession>
    <name>Q63SB8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004204640.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108998.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2406"/>
    <dbReference type="EnsemblBacteria" id="CAH36409">
        <property type="protein sequence ID" value="CAH36409"/>
        <property type="gene ID" value="BPSL2406"/>
    </dbReference>
    <dbReference type="GeneID" id="56596317"/>
    <dbReference type="KEGG" id="bps:BPSL2406"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2989"/>
    <dbReference type="eggNOG" id="COG3556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAIPLRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018706">
        <property type="entry name" value="DUF2214_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09980">
        <property type="entry name" value="DUF2214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="16489" checksum="251F8016E12934D4" modified="2004-10-25" version="1">MLTVRWLLAAVHLLGFGFAFASIAARNRALKRVAGSRQAADLSDVFKADAIWGVSALVLIMTGIVRAFGGFEKGGDYYLHAPLFHLKMGALALILVLELVPMTGLIRWRMTARRGMLPELARARAYARIGHVQAMLVAVIVLAAAGMARGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SH9</accession>
    <name>Q63SH9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192839.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108937.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2341"/>
    <dbReference type="EnsemblBacteria" id="CAH36344">
        <property type="protein sequence ID" value="CAH36344"/>
        <property type="gene ID" value="BPSL2341"/>
    </dbReference>
    <dbReference type="GeneID" id="56596247"/>
    <dbReference type="KEGG" id="bps:BPSL2341"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3078"/>
    <dbReference type="eggNOG" id="COG3758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRMPWKN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37943">
        <property type="entry name" value="PTHR37943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="219" mass="22554" checksum="6F6946D5998F60D5" modified="2004-10-25" version="1">MRAASSAMQASLIRADALVAAPWKNGGGVTREIAAHPLRERAGHGALDAFAWRVSVADVADAGPFSRFPGIDRTLVLLAGAGMTLVDAGGARHALRAPLDRVAFAGEAAIAAELHDGPTRDFNLMTRRDAARGSVDVWRSGASHALRADTVLLFCASGAPVVDLGVDLGVGARVALGACDTLRIDACAHGEFRCAIRGEGVLLAVGVTLLQDNAQGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SM7</accession>
    <name>Q63SM7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550197.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108889.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2293"/>
    <dbReference type="EnsemblBacteria" id="CAH36296">
        <property type="protein sequence ID" value="CAH36296"/>
        <property type="gene ID" value="BPSL2293"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2293"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3136"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PMAGKGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="483" mass="52793" checksum="CC4FDFB4DE341775" modified="2004-10-25" version="1">MQVQSMHFKARAGEKLADARLQENLRRLSTKFVSGRAEAVTQIDFVATRAQLKARRDRALERLDVWLEMFEREAARRGTTVLYAQTTQDAAKLVADIARRHDVKKVIKTKSMVTEEANLNAVLARLGVQSIETDLGEYILQINGNEPPSHIIAPVLHRDKEEIADLFAKTHGRARLTDISEMTREAREVLRPHFLSADMGVTGGNFVIAETGSVVLVTNEGNEGMCTVLPRVHVAVTGIEKVLPTLEDLATAMRLLPRSATGQKTSNYFSLLTGVRGDGDEDGPEHAYVVLVDGGRSGLIGGEFQEMLRCIRCGACMNHCPVYQKVGGHAYGWVYPGPMGSVLTPSYVGLANALDLPQAATLCGECDSVCPVGIPISGLLRKLREKQVERRLRPWRERAALAAWGFFARRPALYALATKLAVRVLERAGGSAGGVAGMLGRMPFAGGWARGWTATRDIPAPAGRTFRELYAASRTHLDPSSTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SN9</accession>
    <name>SYK_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="1">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lysS</name>
        <name type="ordered locus">BPSL2281</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205152.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108877.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SN9"/>
    <dbReference type="SMR" id="Q63SN9"/>
    <dbReference type="STRING" id="272560.BPSL2281"/>
    <dbReference type="EnsemblBacteria" id="CAH36284">
        <property type="protein sequence ID" value="CAH36284"/>
        <property type="gene ID" value="BPSL2281"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2281"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3148"/>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000012858" description="Lysine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <sequence length="508" mass="57144" checksum="02D59DF27507C910" modified="2004-10-25" version="1">MTEPTQPQAAVAADENQIVAERRGKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEALDAKALDVAVAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETRATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIRYQGRELDLAKPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVSPLARESDTVAGITERFELFVTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFPHLRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SP6</accession>
    <name>Q63SP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108870.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2274"/>
    <dbReference type="EnsemblBacteria" id="CAH36277">
        <property type="protein sequence ID" value="CAH36277"/>
        <property type="gene ID" value="BPSL2274"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2274"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2583"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTDKQGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="601"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="856" mass="89317" checksum="A197B467FECD0D39" modified="2004-10-25" version="1">MDMRRSGGAQGGGAMRAKCGAFALGVVALQQQAALPGAAAWAGGALAFGLCVWLALVWRGDARARAAGFCACCCAAALAGFGYAAARAQWRLADTLPAQWEGRDIVVTGAVRGLPSRDANGVRFLFDVDANDARIARFPATLSLGWYAFGRPGAQPPELVPGDRWRLRVRLKRPHGNANFGVRDAEAAWLARGIRALGYVSAPRDARRLAGRASGVAAALDRLRARLRGRIAEALGDAAHRGIVVALAIGAQDDIADDDRRILRDTGTSHLVAISGLHVGMVGGLCAWLAGGLWRRSGYVGRDWPLVVPAQKVAALGAIVGGAGYAALAGFNVPVQRAWWMLAAAGVAYLSARSLAPSSVLAAALGCVLLVDPWAVTSAGFWLSFCAVAAILAVSSGWRAPRDLDETRGARHALGGVGHEGAPPSHRARWRAACGFAWGWAARAFGRLARRVRDAARAQFAVTIALAPLTVLWFAQIPLAGPLANAFAIPWVGSLVTPIVLAGIVLPAPLDASAYALAHALVQALMRLLDATAGAGRTVWMLPAPDGFALAAAAVGVAWALMPRGWPVRCAAPLAWLPLVAPAPLAPPDGAFRLTALDVGQGSAVLIETARHTLLFDAGPGPEASNAGERIVVPFLRARGVRALDALVVSHADSDHAGGAPAVLGSIAVAQMAGGLPPSNRLWRAARAAGVADALPCVAGQRWRWDGVEFDALWPAGGPRAGGATNAQSCVLRVSAGGRAALLTGDVDARSERALVAGSRGALAAQVLVVPHHGSRTSSTEPFLDSVKPRIAIFQVGYANRFHHPHPTVWARYAGRGIELPRTDRDGAVRVDVTSSGALAEPVRYRDAHRRYWMGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ST1</accession>
    <name>TILS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tilS</name>
        <name type="ordered locus">BPSL2240</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524749.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108835.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63ST1"/>
    <dbReference type="SMR" id="Q63ST1"/>
    <dbReference type="STRING" id="272560.BPSL2240"/>
    <dbReference type="EnsemblBacteria" id="CAH36242">
        <property type="protein sequence ID" value="CAH36242"/>
        <property type="gene ID" value="BPSL2240"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2240"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2545"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHGDHQW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000181668" description="tRNA(Ile)-lysidine synthase">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <sequence length="489" mass="53136" checksum="FCAB789CEF8A1673" modified="2004-10-25" version="1">MIPPHEFSAERVVFDALGVALSALPDDTPIAIAYSGGLDSTVLLHAAARIAGAGRCIALHVHHGLSANADAWLAHCAETAQALGARFDAARVDVPRASGQGIEASARDARYRALETMCARYGARTLWLAQHADDQAETVLLQLLRGAGIAGLAAMAPQYRPALADVVRMRPLLHLLRAQLERYAQQHALRWIDDESNTDTRYARNALRVDVLPALAPHFPGFRDALARTAQHAAAAQRLLDDLAAIDLRAVARADVRVLSRDALVALDDERGANLLRYWMRSLGLPGASAARLAEMVKQLRAARDAHALRVDHAGWRLRLYRDDVQWEAGDGAASEAARADVADDDAADARDDRADASAAARLPACALAWRGHEVWRLPGWRGSFVFSPVAAHEHDAVPEALLSSAALRACARAGGERMRTRQGGPGRTLKNLFQERGVPAWQRDVPLLYVGERLLFVPRIGVNRATHDGADAPGGWRRIEWRPDMLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T96</accession>
    <name>Q63T96_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108670.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36072">
        <property type="protein sequence ID" value="CAH36072"/>
        <property type="gene ID" value="BPSL2071"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2071"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2342"/>
    <dbReference type="OMA" id="GAMCAGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="64" mass="7073" checksum="B0BD3233F5E816A9" modified="2004-10-25" version="1">MMAVAIAIVIAIAVVIAIANHIARFDEHFVKHFVKHFVKHFVKRSPDASWNESNVVTGAMCAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TA3</accession>
    <name>Q63TA3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108663.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2064"/>
    <dbReference type="EnsemblBacteria" id="CAH36065">
        <property type="protein sequence ID" value="CAH36065"/>
        <property type="gene ID" value="BPSL2064"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2064"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2330"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="44" mass="5474" checksum="E1E28F5B3217A34E" modified="2004-10-25" version="1">MRHEMRDEMRDEMHGEMHGEWPKSNPRRFKRTLVLYLTIFIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TN3</accession>
    <name>Q63TN3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526845.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108533.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1934"/>
    <dbReference type="EnsemblBacteria" id="CAH35933">
        <property type="protein sequence ID" value="CAH35933"/>
        <property type="gene ID" value="BPSL1934"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1934"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4078"/>
    <dbReference type="eggNOG" id="ENOG5032NVB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESGGPMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021267">
        <property type="entry name" value="DUF2844"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11005">
        <property type="entry name" value="DUF2844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266311" evidence="1">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17142" checksum="E5A66BB4DAC297D9" modified="2004-10-25" version="1">MNNKKSSPPTRRRPTRALVAAAAVTFAPATAQSQLGSTVANPSARALVQASSAALPNGAVTMRSYVDAGGTTIHEYATRTGLVFAYTWDGPTSPNLRKLLGERFPTFQSHAVTTDAHARASLHAGRVAQSDFVVEAGGRMRAYVGRAWLPGAVPPGVSIDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TP5</accession>
    <name>Q63TP5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521674.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108521.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1921"/>
    <dbReference type="EnsemblBacteria" id="CAH35921">
        <property type="protein sequence ID" value="CAH35921"/>
        <property type="gene ID" value="BPSL1921"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1921"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4065"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGNVMPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="554" mass="59041" checksum="68BB2BE2CBD1B92B" modified="2004-10-25" version="1">MTDTHDIDSSESAHAVATARADDAPEQSAADAGGEDRPRRGLRRGPRSLIARRRAAAKSKHSDAPESADAAPAADAGAGADVAKAPARAPRGKDAAAKPPRKTAGKREGAARQGAQPKRGAQQAAAAVAPSAEAGQDDVFAYVISPAFDADNNAPGGGVRAPMLRRGRQTQPKRVLSPDDDAPKLHKVLAEAGMGSRREMEELIIAGRVSVNGEPAHIGQRIMPTDQVRINGKPVKRKLPSKPPRVLLYHKPTGEIVSHADPEGRPSVFDRLPPMKTAKWLAVGRLDFNTEGLLMLTTSGDLANRFMHPRYSVEREYAVRVVGELSEASRQKLLHGVELDDGPANFLRIRDGGGEGTNHWYHVALAEGRNREVRRMFEAVGLMVSRLIRTRHGPIPLPRGLKRGRWEELDEAQVRRLMSTVGLKAPTEDKGGKRGGPAERRQPDPMQTSMGFINREPVLTTHGQLDQPRRGRRGPAGGGFGAGLGGGYAGLPGYGGASRQGGRDVDGNRASYGGAGANKRGAGKGGRNPNGNRAEGGARGGPRTPQQRNRSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TQ7</accession>
    <name>Q63TQ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="4">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sucA</name>
        <name evidence="8" type="ordered locus">BPSL1909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526855.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108509.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1909"/>
    <dbReference type="EnsemblBacteria" id="CAH35909">
        <property type="protein sequence ID" value="CAH35909"/>
        <property type="gene ID" value="BPSL1909"/>
    </dbReference>
    <dbReference type="GeneID" id="56526277"/>
    <dbReference type="KEGG" id="bps:BPSL1909"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4053"/>
    <dbReference type="eggNOG" id="COG0567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="600"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="954" mass="106451" checksum="12CDC28BDBD06295" modified="2004-10-25" version="1">MSDVMKQFQLNSYLFGGNASYVEELYEAYLDNPASVPDNWREYFDALQNVPATDGSNASDVAHNPIVESFAQRAKANAFIPRESGGNLATARKQVHVQSLISAYRFLGSQWANLDPLKRRERPAIPELEPAFYDFSEADLDQTFSASNLYFGFEQASLRDIVKGLRDTYCGTIGAEFMYISDPEQKRWWQERLESTRATPNFSADKKKHILNRLTAGEGLERYLHTKYVGQKRFSLEGGESFIAAMDEVVQHAGSKGVQEIVIGMAHRGRLNVLVNTLGKMPADLFAEFEGKHVDDLPAGDVKYHKGFSSDIATEGGPVHLSLAFNPSHLEIVNPVVEGSAKARMDRRGDADGLQVLPVQIHGDAAFAGQGVVMETLNLAQTRGYGTHGTLHIVINNQIGFTTSDPRDARSTLYCTDVVKMIEAPVLHVNGDDPEAVVLATQIAIDYRMQFHKDVVIDIVCFRKLGHNEQDTPAVTQPLMYKKIAQHPGTRALYAEKLVQQGVISADDADGFVKAYRKAMDDGHHTVDPVLSNYKSKYAVDWMPFLNRKWTDAADTAVPLAELKRLGERITTVPENFKVHPLVERVINDRRNMARGDQPLDWGMGEHLAYASLVASGYAVRLTGQDSGRGTFTHRHAVLHDQNRERWNDGTYVPLQNVSEGQAKFNVIDSVLSEEAVLGFEYGYSTAEPNTLVLWEAQFGDFANGAQVVIDQFISSGEVKWGRVSGLTMLLPHGYEGQGPEHSSARIERYLQLCAEHNMQVVQPTTPAQIFHLLRRQMIRLFRKPLIVATPKSLLRHKEAVSDLSELAKGSFQPVLGEVDGGIDAKKVKRVIACSGRVYYDLVAHRREAKANDVAIVRIEQLYPFAHKQFEAEMKKYENATEVVWVQDEPQNQGPWFYVEHHLKEGMKEGQKLAYSGRPASASPAVGYYAKHYEQQKALVEGAFGRLKSASIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TY9</accession>
    <name>Q63TY9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_PrkA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192719.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108427.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1828"/>
    <dbReference type="EnsemblBacteria" id="CAH35827">
        <property type="protein sequence ID" value="CAH35827"/>
        <property type="gene ID" value="BPSL1828"/>
    </dbReference>
    <dbReference type="GeneID" id="56595618"/>
    <dbReference type="KEGG" id="bps:BPSL1828"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3952"/>
    <dbReference type="eggNOG" id="COG2766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFYGMED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016230">
        <property type="entry name" value="Ser_kinase_PrkA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000549">
        <property type="entry name" value="Ser_prot_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="640" mass="73476" checksum="D61D8DF29029A02E" modified="2004-10-25" version="1">MDIYSSFANRFEKTREEEFSLEEYLALCKNDPSAYAAAGERMLEAIGEPEQIDTRNDPRLSRIFANKVIKVYPAFREFYGMEEVIEQVVAYFRHAAQGLEEKKQILYLLGPVGGGKSSIAERLKQLMERVPFYALKGSPVNESPLGLFDYDEDGPILEEQYGIPRRYLKSILSPWAVKRLHEYNGDIRRFRVVRRYPSILRQIGIAKTEPGDENNQDISSLVGKVDIRKLEQYAQDDADAYSYSGGLCLANQGLLEFVEMFKAPIKVLHPLLTATQEGNFKGTEGFGAIPFDGIILAHSNESEWKAFRNNRNNEALLDRIFVVKVPYCLRVSEEIKIYEKLIRNSSLAEAVCAPGTLKMMAQLSVLTRLHEPENSSLFSKMQVYDGENLKDTDPKAKSYQEYRDYAGVDEGMTGVSTRFAFKILSRVFNFDSTEVAANPVHLMYVLEQQIEREQFPPETEQKYLSFVKDLLASRYAEFIGKEIQTAYLESYSEYGQNIFDRYVTYADFWIQDQEFRDHDTGESFDRAALNAELEKIEKPAGISNPKDFRNEIVNFVLRARAANGGKNPAWVSYEKLRVVIEKKMFSNTEELLPVISFNAKGSAEEQRKHEDFVNRMVAKGYTPKQVRLLCDWYLRVRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U18</accession>
    <name>Q63U18_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative fimbrial chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL1799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1 6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the periplasmic pilus chaperone family.</text>
    </comment>
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    </dbReference>
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        <property type="protein sequence ID" value="CAH35798"/>
        <property type="gene ID" value="BPSL1799"/>
    </dbReference>
    <dbReference type="GeneID" id="56529486"/>
    <dbReference type="KEGG" id="bps:BPSL1799"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3913"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036316">
        <property type="entry name" value="Pili_assmbl_chap_C_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHAPERONPILI"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PILI_CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267145" evidence="7">
        <location>
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            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="8">
        <location>
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            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GeneID" id="56529485"/>
    <dbReference type="KEGG" id="bps:BPSL1798"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3912"/>
    <dbReference type="eggNOG" id="COG3539">
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    <dbReference type="OMA" id="TTGYCYK"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAH35797.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="341" mass="36715" checksum="5BB18432603DA95A" modified="2004-10-25" version="1">MSALARLLPRRAPGWLAWACAALVVALAQPAWAVRCLTNSGQTSLTEPIGNVASYPTDAPDGYVIWISAPRTTDGYCYKDLGGAGNLNIVDNIYFYANPDGKNPAAWGLEIGIRYRGIDHFGAGSRPGTGVPTGFAVPPCSQTDFNAKRCPKIPVSITYQVVVRKKGAWVQPPGDVYTVFQFDGEKGLNNTNPSFQYKLSGLQNLKPTPCMVDVTVTPEPGIVKFGQVQSSGNGFSPAVPRKPFSLALTKKCSIAVRVDGYFETSQTVRDGLLVPQSDSNFGIGIEDRNGHAIAFNRQFVLTQMPANVSYQNIVLDAVLKSFGAPKIGPFTGTATIRLFIY</sequence>
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    <accession>Q63UP7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ordered locus">BPSL1549</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Betaproteobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2011" name="Science" volume="334" first="821" last="824">
            <title>A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.</title>
            <authorList>
                <person name="Cruz-Migoni A."/>
                <person name="Hautbergue G.M."/>
                <person name="Artymiuk P.J."/>
                <person name="Baker P.J."/>
                <person name="Bokori-Brown M."/>
                <person name="Chang C.T."/>
                <person name="Dickman M.J."/>
                <person name="Essex-Lopresti A."/>
                <person name="Harding S.V."/>
                <person name="Mahadi N.M."/>
                <person name="Marshall L.E."/>
                <person name="Mobbs G.W."/>
                <person name="Mohamed R."/>
                <person name="Nathan S."/>
                <person name="Ngugi S.A."/>
                <person name="Ong C."/>
                <person name="Ooi W.F."/>
                <person name="Partridge L.J."/>
                <person name="Phillips H.L."/>
                <person name="Raih M.F."/>
                <person name="Ruzheinikov S."/>
                <person name="Sarkar-Tyson M."/>
                <person name="Sedelnikova S.E."/>
                <person name="Smither S.J."/>
                <person name="Tan P."/>
                <person name="Titball R.W."/>
                <person name="Wilson S.A."/>
                <person name="Rice D.W."/>
            </authorList>
            <dbReference type="PubMed" id="22076380"/>
            <dbReference type="DOI" id="10.1126/science.1211915"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.04 ANGSTROMS) OF 2-211</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-06" db="PDB data bank">
            <title>Molecular basis of the specificity of the Burkholderia Lethal Factor 1 for its eukaryotic target, eIF4A.</title>
            <authorList>
                <person name="Mobbs G.W."/>
                <person name="Aziz A.A."/>
                <person name="Blackburn G.M."/>
                <person name="Sedelnikova S.E."/>
                <person name="Minshull T.C."/>
                <person name="Dickman M.J."/>
                <person name="Baker P.J."/>
                <person name="Nathan S."/>
                <person name="Firdaus-Raih M."/>
                <person name="Rice D.W."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (0.99 ANGSTROMS)</scope>
    </reference>
    <reference evidence="6 7" key="4">
        <citation type="journal article" date="2022" name="Commun. Biol." volume="5" first="272" last="272">
            <title>Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1.</title>
            <authorList>
                <person name="Mobbs G.W."/>
                <person name="Aziz A.A."/>
                <person name="Dix S.R."/>
                <person name="Blackburn G.M."/>
                <person name="Sedelnikova S.E."/>
                <person name="Minshull T.C."/>
                <person name="Dickman M.J."/>
                <person name="Baker P.J."/>
                <person name="Nathan S."/>
                <person name="Raih M.F."/>
                <person name="Rice D.W."/>
            </authorList>
            <dbReference type="PubMed" id="35347220"/>
            <dbReference type="DOI" id="10.1038/s42003-022-03186-2"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531382.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108169.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3TU8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.04 A"/>
        <property type="chains" value="A=2-211"/>
    </dbReference>
    <dbReference type="PDB" id="3TUA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.09 A"/>
        <property type="chains" value="A=2-211"/>
    </dbReference>
    <dbReference type="PDB" id="6RVU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="0.99 A"/>
        <property type="chains" value="A=1-211"/>
    </dbReference>
    <dbReference type="PDB" id="7PPZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.52 A"/>
        <property type="chains" value="A=1-211"/>
    </dbReference>
    <dbReference type="PDB" id="7PQ0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A=1-211"/>
    </dbReference>
    <dbReference type="PDBsum" id="3TU8"/>
    <dbReference type="PDBsum" id="3TUA"/>
    <dbReference type="SMR" id="Q63UP7"/>
    <dbReference type="STRING" id="272560.BPSL1549"/>
    <dbReference type="EnsemblBacteria" id="CAH35550">
        <property type="protein sequence ID" value="CAH35550"/>
        <property type="gene ID" value="BPSL1549"/>
    </dbReference>
    <dbReference type="GeneID" id="56529274"/>
    <dbReference type="KEGG" id="bps:BPSL1549"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3594"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051097">
        <property type="term" value="P:negative regulation of helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12812">
        <property type="entry name" value="BPSL1549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033808">
        <property type="entry name" value="BPSL1549"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17752">
        <property type="entry name" value="BLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3TU8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3TUA"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6RVU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7PPZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7PQ0"/>
        </source>
    </evidence>
    <sequence length="211" mass="23342" checksum="CD8F2C23BBFFB400" modified="2004-10-25" version="1">MPNSLEAQIRQAMKTGSTLTIEFDQALNQKSPGTLNVFLHPANGGVRIDLDSGNQGEPAKILWLPWKQGELQTLQPGSISTVDMLFFTYYLSGCKVFAGDGGPVWHIDAPVEANQFWRRMSSDEWMEDWEVGTDRQVAYLHRAGQSDSLWNLSAYLEGAAPSTYGRDNLGQAVVGGIVTGRQQMSLYQYATTSSGSSAWSPLTYTLQQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UR3</accession>
    <name>Q63UR3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL1533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108153.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1533"/>
    <dbReference type="EnsemblBacteria" id="CAH35534">
        <property type="protein sequence ID" value="CAH35534"/>
        <property type="gene ID" value="BPSL1533"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1533"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1724"/>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFADCVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="276" mass="28457" checksum="C9FA5D28D21B2175" modified="2004-10-25" version="1">MLRPLTLADCVQPDWQAPPRVRALVSTRNGGVSEPPYGAWGGDGGEVAGGMNLGRHTGDDPAHVEANRARLLALAGQSRAAWLEQVHGTEVVRAEDVLAAGEGGAVRADASVAATPGAVCVVMVADCLPVLLCDDAGRAVGAAHAGWRGLVAGIVEKTAERVAALAGGGADRLHAYLGPAIGPGAFEVGADVRSAFLDAAPLADYAATECAFAARAHAPGKYLANLYALARLRLARVGVTRVSGGAACTATERERFYSYRRDRVTGRMAALIWLAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UT5</accession>
    <name>RLMN_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="1">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmN</name>
        <name type="ordered locus">BPSL1511</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192451.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108131.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UT5"/>
    <dbReference type="SMR" id="Q63UT5"/>
    <dbReference type="STRING" id="272560.BPSL1511"/>
    <dbReference type="EnsemblBacteria" id="CAH35512">
        <property type="protein sequence ID" value="CAH35512"/>
        <property type="gene ID" value="BPSL1511"/>
    </dbReference>
    <dbReference type="GeneID" id="56595750"/>
    <dbReference type="KEGG" id="bps:BPSL1511"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3548"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000350081" description="Dual-specificity RNA methyltransferase RlmN">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="101"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="1">
        <location>
            <begin position="108"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="378" mass="41131" checksum="4D42D97D44FC6BF4" modified="2004-10-25" version="1">MAGETIVNLLDLDAEGLVAYCGSLGEKAFRAKQLQRWIHQYNAADFDGMTDLAKSLREKLKGRAVIGTPDILSDHVSADGTRKWLINVGNGNAVETVFIPEETRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLSTGEIVGQLRMAEFALRASLGRAPGPNGKAERVITNVVMMGMGEPLLNYSAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLGAELPVALAVSLHAPNDALRDELVPLNKKHPLRELMAACQRYLKVAPRDFITFEYCMLDGVNDTEAHARELLAVTRDVPCKFNLIPFNPFPESGLVRSKTEQIKRFAQVLIDAGVVTTIRKTRGDDIDAACGQLAGAVKDRTRLAERTGASKIIEVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UV8</accession>
    <name>Q63UV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527172.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108108.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1488"/>
    <dbReference type="EnsemblBacteria" id="CAH35489">
        <property type="protein sequence ID" value="CAH35489"/>
        <property type="gene ID" value="BPSL1488"/>
    </dbReference>
    <dbReference type="GeneID" id="56529213"/>
    <dbReference type="KEGG" id="bps:BPSL1488"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3521"/>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVGCTRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="132" mass="14509" checksum="D87C9AD4A1243FC5" modified="2004-10-25" version="1">MEQRISEDRYTRGWNKLKEIDGKVGERVVAALAPIAPDFGRLLVEFGFGDIYSRPQLDLKSREIATIASLATLGHAQPQLKVHIEAALNVGCTRDEIVEVFMQMALYAGFPAALNALFAAHDVFGQRDAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V47</accession>
    <name>Q63V47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative porin signal peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527230.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108019.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1397"/>
    <dbReference type="EnsemblBacteria" id="CAH35398">
        <property type="protein sequence ID" value="CAH35398"/>
        <property type="gene ID" value="BPSL1397"/>
    </dbReference>
    <dbReference type="GeneID" id="56529118"/>
    <dbReference type="KEGG" id="bps:BPSL1397"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3406"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGHPTLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0626">Porin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266794" evidence="5">
        <location>
            <begin position="33"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="6">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="37581" checksum="BE028B3D36DAC04F" modified="2004-10-25" version="1">MTTLRLRSPHRCRPPALAAAATLAALSGPAHAQSTLTLYGVADAGVQYLSRADGRHAAWRLQNYGILPSQLGIKGEEDLGGGWRARFQLEQGINLNDGTATVPGYAFFRGAYVGMGGPAGTVTLGRQFSTLFDKTLFYDPLWYASYSGQGVLVPLSANFVDHSIKFQSATFAGFDVEALAAMAGIAGNTRAGRVLELGGQFTSRGLSASAVLHRSHGTAQGGADRSAQRRDIGTFAARYAFASLPLTVHAGVQRLTGELDPARTIVWGGARYQASGRFGFAGGIYHTDSPTPQVGHPTLFIASTTCSLSKRTVAYLNLGYAKNSGRSAQTVYEYDPTPLAGASQFGAMLGMYHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VJ1</accession>
    <name>Q63VJ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107875.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1254"/>
    <dbReference type="EnsemblBacteria" id="CAH35248">
        <property type="protein sequence ID" value="CAH35248"/>
        <property type="gene ID" value="BPSL1254"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1254"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1388"/>
    <dbReference type="eggNOG" id="ENOG502Z9XK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PIAYRTM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="358" mass="39520" checksum="59C5562EB378822E" modified="2004-10-25" version="1">MLSASFRPKSGFVVPVSIAGKTYHFLVDTGASHTAIDNRLAQSITQPSTDEQIPIAYRTMLEKGLTTADGVLPRERVRLWQPLPIALGSYQVPSFYPWLGLDLSLLSQVLGTQIDGIVGIEIFRQLSWVADNRSGTLTVWRHPPAAQRFAHCVPYQDSFGQSPAVSVDFRDRWTMFRFDTGARYSIASAPTLAYLASHKAAMPLGGTVPSMSANGVGESRDHFVSGLSFDGRPVGRLRVAEGGGDMLGMNFLARLDRYMFVPSTMEFCYDAGRFTQDDPQPLRTIAIRFVDGRVELFHNRPEDLRRYGLENGDVLVEIDGKRVEAPAIDDVRDRLSTAPAGSLDIVVERGGSRRAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL5</accession>
    <name>Q63VL5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526465.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107851.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1229"/>
    <dbReference type="EnsemblBacteria" id="CAH35224">
        <property type="protein sequence ID" value="CAH35224"/>
        <property type="gene ID" value="BPSL1229"/>
    </dbReference>
    <dbReference type="GeneID" id="56526632"/>
    <dbReference type="KEGG" id="bps:BPSL1229"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.297"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYRTIDN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="234"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="377" mass="40192" checksum="1C16F1CEF557670E" modified="2004-10-25" version="1">MNFTFSEEQQQFAHALRRYLDERYGFDARRAIIHSDAGVCDEQWRAFAELGLTALPVPEAHGGFGGGAVDMLVATQELGRALVVEPYWATAVGIEALRVAGSADGEDAALLARAAQGDAKLAVAFHEPHARHDLFAIETLARPDGDGFALTGVKSVVRHGAQADVLIAPARLPNGAIGLFAIARGAAGADIVDYRTIDGQRAATVRFSDTPARALAGGERDAAALERIADYGVVLLCGEAIGALDALNHATLDYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYASDDANARRKAVSAAKARVGQAARFVGQQAVQLHGGMGVTDEVAAAHLFKRLSIIETTLGDVDHHLARFASLPDFALLQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VW0</accession>
    <name>Q63VW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107756.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1135"/>
    <dbReference type="ESTHER" id="burma-a5tq93">
        <property type="family name" value="Pectinacetylesterase-Notum"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35129">
        <property type="protein sequence ID" value="CAH35129"/>
        <property type="gene ID" value="BPSL1135"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1135"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1256"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YVPYCTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562">
        <property type="entry name" value="PTHR21562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="465" mass="50814" checksum="C6FC35BE056CDBBA" modified="2004-10-25" version="1">MEESMLVRECLECLRRLCVAGLLSAAAADGHAAVAAAQDPSIPYYSWYEVTLPESSGASCGNGTPMRFYINRAQSDNLLYMMEPGGACWDHGTCTETATGAQAGLGAFNPDGIPHNYVNGTVQQSLKTSFLSPLMTRMDLAHILVGEPKVETQEWTQVFVPYCTGDIHMGSAVRSYASPSGDWRIQHYSGLKNVRVIAQWLVDHGFGKPSRLLVYGTSAGGYGTLGNYATLRGTLQPQSHSSLLDDAGTVFNTRFGADPAAYPSVGLYDKVRDEWGMTAPDGMITVNSRLTRYFDPGNMGSAYAALSATYPHDRFGYTTYRRDRIIAAYHYRPFVPAVIAAPDDATKDALSLAMFDRELSDLKQVLNPLPNFGYFIPWARDDFMGNHQVTAVSFTGSGIHENGIDADVGTFVADLLNQQDPADVPVMKAYRTEQWSDFTFSTFLAWLDSIFNLTGEAGPISGHRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W06</accession>
    <name>UBIC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable chorismate pyruvate-lyase</fullName>
            <shortName evidence="1">CL</shortName>
            <shortName evidence="1">CPL</shortName>
            <ecNumber evidence="1">4.1.3.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiC</name>
        <name type="ordered locus">BPSL1088</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = 4-hydroxybenzoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:16505"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="EC" id="4.1.3.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.40" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550738.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107710.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63W06"/>
    <dbReference type="SMR" id="Q63W06"/>
    <dbReference type="STRING" id="272560.BPSL1088"/>
    <dbReference type="EnsemblBacteria" id="CAH35082">
        <property type="protein sequence ID" value="CAH35082"/>
        <property type="gene ID" value="BPSL1088"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1088"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.470"/>
    <dbReference type="eggNOG" id="COG3161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELWGRRS"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008813">
        <property type="term" value="F:chorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042866">
        <property type="term" value="P:pyruvate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01632">
        <property type="entry name" value="UbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007440">
        <property type="entry name" value="Chorismate--pyruvate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38683">
        <property type="entry name" value="PTHR38683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04345">
        <property type="entry name" value="Chor_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000240538" description="Probable chorismate pyruvate-lyase">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="197" mass="21770" checksum="E009ED2A861D9EA1" modified="2004-10-25" version="1">MRFDAADAHWRETPRPGASSAQKDWLTRGGSLTAHLARLGRVTVRVTRETVAAPWADEHRALSCASRAPVWVREVVLAVDGAPFVAAHSIAPLAASKGVWQAMRRLRTRPLAELLYSDPEVTRSALVSRRVLAGHPLFSLASLALARAYATEHAFAARRSVFERRGTPLMVTECMLPALWRHLDAHGERRARGLEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W44</accession>
    <name>Q63W44_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522515.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107672.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1045"/>
    <dbReference type="EnsemblBacteria" id="CAH35041">
        <property type="protein sequence ID" value="CAH35041"/>
        <property type="gene ID" value="BPSL1045"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1045"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.519"/>
    <dbReference type="eggNOG" id="COG3911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TPPWPEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="200" mass="21820" checksum="7C23FB5BE0CAD327" modified="2004-10-25" version="1">MPEPGVGAHAGGLDADAALARFFVITGGPGSGKSTLIDALEARGYARSHEAGRGVIQDQVAIGGHALPWRDRAAFADMMLGWEMRSHHLARRARGPVFFDRGVPDVIGYLKLSALPVPAHLVAAAERFRYRRDVFIAPPWPEIYAQDAERRQDYAEAVRTYGAMVDTYAACGYRLIELPRASVDERCRFVLDVVEAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB5</accession>
    <name>Q63WB5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193808.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107601.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0973"/>
    <dbReference type="EnsemblBacteria" id="CAH34969">
        <property type="protein sequence ID" value="CAH34969"/>
        <property type="gene ID" value="BPSL0973"/>
    </dbReference>
    <dbReference type="GeneID" id="56596218"/>
    <dbReference type="KEGG" id="bps:BPSL0973"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.601"/>
    <dbReference type="eggNOG" id="COG2947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWDGIRN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="2">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="17485" checksum="F42A2BD32CE5AB16" modified="2004-10-25" version="1">MRYWLMKSEPDEASIDDLAAAPDQTLPWTGVRNYQARNFMRDTMQIGDGVLFYHSSCPEPGIAGLARVSSTPYPDPTQFDSRSPYHDPKSTREAPRWVLVDVRFVRKSPLVPLAALREHEALANMRVLAKGNRLSITPVTPNEWRFITQRLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WJ6</accession>
    <name>Q63WJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530837.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107520.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0894"/>
    <dbReference type="EnsemblBacteria" id="CAH34887">
        <property type="protein sequence ID" value="CAH34887"/>
        <property type="gene ID" value="BPSL0894"/>
    </dbReference>
    <dbReference type="GeneID" id="56526927"/>
    <dbReference type="KEGG" id="bps:BPSL0894"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.690"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TMWMKNT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266640" evidence="1">
        <location>
            <begin position="32"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="18321" checksum="B793C016D9FAB412" modified="2004-10-25" version="1">MRSSPRSSLARLARAAVFPVALALAASGMHAAFAQTTPLPPGAKQPSEFPRVKLRAGMYVIDAAVAANDADREQGLMYRSRLAPNEGMLFVFNENAVHCFWMKNTLIPLSIAFIRADGTITDIDEMKAETTDNHCPRNNGVYALEMSSGWFAAKGVKPGMKIDGLPKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WM6</accession>
    <name>Q63WM6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189587.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107490.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0865"/>
    <dbReference type="EnsemblBacteria" id="CAH34857">
        <property type="protein sequence ID" value="CAH34857"/>
        <property type="gene ID" value="BPSL0865"/>
    </dbReference>
    <dbReference type="GeneID" id="56596497"/>
    <dbReference type="KEGG" id="bps:BPSL0865"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.731"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17732" checksum="42D9357B0CFDC594" modified="2004-10-25" version="1">MSKSKHVSETPATQFLRRHGVAFGEHVYEYVEHGGTSESARQLGVDEHAVVKTLVMEDEHAKPLIILMHGDRTVSTKNLARQIGAKRVEPCKPEVANRHSGYLVGGTSPFGTKKAMPVYVESTILDLPSIYLNGGRRGYLVSLAPAVLATLLQARPVQCASVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WN3</accession>
    <name>Q63WN3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526255.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107483.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0858"/>
    <dbReference type="EnsemblBacteria" id="CAH34850">
        <property type="protein sequence ID" value="CAH34850"/>
        <property type="gene ID" value="BPSL0858"/>
    </dbReference>
    <dbReference type="GeneID" id="56526963"/>
    <dbReference type="KEGG" id="bps:BPSL0858"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.740"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTLTWPV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="142"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="30935" checksum="A91320711A265380" modified="2004-10-25" version="1">MAPKDLLLALVVILAWGVNFVVIKVGLHGVPPMLLGGLRFLLASVPAVFFVRRPRIPWRLLVLYGSTILLGQFVFLFSAMYVGMPAGLASLVLQAQAFFTLFFARFALGERLRAQNLVGLAIAAVGLVAIAVQGGRGMTLAGFALTIGAAALWALGNVVTKKVGKVDLVSLVVWASLVPPVPFFALSYGFEGPQRIGAALTSLSGASIFAIVYLAFVATLLGYGLWSRLMSRYPAGQVAPFSLLVPVVGLASSALLLDERLTHAQLAGAALVMAGLAVNVFGDRVVRRLFAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WP9</accession>
    <name>Q63WP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189216.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107467.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0843"/>
    <dbReference type="EnsemblBacteria" id="CAH34834">
        <property type="protein sequence ID" value="CAH34834"/>
        <property type="gene ID" value="BPSL0843"/>
    </dbReference>
    <dbReference type="GeneID" id="56596519"/>
    <dbReference type="KEGG" id="bps:BPSL0843"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.758"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFGGEKH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="483" mass="49610" checksum="2F2E1D01E6AE1B71" modified="2004-10-25" version="1">MQDISMLIGGERRPATGGATFERRNPLDGELATRAPAATAADARAAVDAASAAFAPWAALGPSARRALLLKAAAALEGKRDAFIAAMAAETGASAIWARFNVELAANGLVEAAALTTQIGGELIPSDVPGSLAMGVRQPAGVVLGIAPWNAPVILGVRALALPLACGNTVVFKGSELCPATHGLIADALHEAGLPRGVVNFVTNAPADAGAVVDAMIAHPAVRRVNFTGSTRVGRIIAERCARHLKPAVLELGGKAPFVVLDDADLDAAVAAAAFGAFANSGQICMSTERIIVDERIADAFVAKLADKAASLPLGDPRNGPVVLGSVIDAQTVERCNALIDDALAKGAVLRCGGKADSTLMPATLVDRVTPAMRLYAEESFGPVKGIVRVAGEEAAIACANDNAFGLSSAVFSRDVARAMRVAARIEAGICHVNGPTVHDEAQMPFGGMKDSGFGHFGGKAGIAEFTDLRWITVQTAPRHYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X49</accession>
    <name>Q63X49_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glpD</name>
        <name evidence="9" type="ordered locus">BPSL0688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526148.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107317.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0688"/>
    <dbReference type="EnsemblBacteria" id="CAH34681">
        <property type="protein sequence ID" value="CAH34681"/>
        <property type="gene ID" value="BPSL0688"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0688"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.929"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAYSDCW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="8"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="386"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="510" mass="56444" checksum="52DF80ADAB00A85D" modified="2004-10-25" version="1">MTQQNRYDLLVVGGGINGAGIARDAAGRGLSVLLCEQDDLASHTSSSSTKLIHGGLRYLEYKEFGLVRKALQERETLLRAAPHIMWPLRFVMPHMPNLRPAWLIRVGLFLYDHLAKRELLPGSRGIDMRRHPAGAPLVDSIKRGFVYSDGWVDDARLVVLNALDAQERGARILTRTKLVSAERRDGQWHARLQRADGSTLDVRARAIANAAGPWVGEVLHGALGRGAQHSVRLVKGSHIITPRLFDHDHAYIFQNPDKRIIFAIPYERDFTLIGTTDVEYRDDPSRVAIDRDETRYLCESINRYFKRKISPADVCWTYSGVRPLLEDENADNPSAVTRDYRLELDDGEGAPLLSVFGGKITTFRKLAEEATDMLGGALGAARGAWTAGVPLPGGDIANARFAPFAEAFAKRHPWLPAALARRYARAYGTRAERVIGRARSLAELGEQLAPGLYEAELRYLRDVEWAGCADDVLWRRSKLGLHVAPGTLEPVTAALDAWFGAAREAASAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X92</accession>
    <name>Q63X92_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dATP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189197.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107274.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0645"/>
    <dbReference type="EnsemblBacteria" id="CAH34638">
        <property type="protein sequence ID" value="CAH34638"/>
        <property type="gene ID" value="BPSL0645"/>
    </dbReference>
    <dbReference type="GeneID" id="56596660"/>
    <dbReference type="KEGG" id="bps:BPSL0645"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.977"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTEHVFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019177">
        <property type="term" value="F:dihydroneopterin triphosphate pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003564">
        <property type="entry name" value="DHNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01404">
        <property type="entry name" value="NPPPHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="17543" checksum="3B91FA76BB28C598" modified="2004-10-25" version="1">MTKPPKIPESVLVVIHTPALDVLVIKRADQPDFWQSVTGSKDALDEPIAQVAAREVAEETGIVVGGPGLAPAALVDWHHAIEYTIYPQYLHRYAPGVTRNVEHWFSLEVPARVDVTLSPREHTDYLWLPYREAAARCYSPSNAEAILQLPERLASRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XD7</accession>
    <name>Q63XD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189426.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107228.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0599"/>
    <dbReference type="EnsemblBacteria" id="CAH34592">
        <property type="protein sequence ID" value="CAH34592"/>
        <property type="gene ID" value="BPSL0599"/>
    </dbReference>
    <dbReference type="GeneID" id="56593645"/>
    <dbReference type="KEGG" id="bps:BPSL0599"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1032"/>
    <dbReference type="eggNOG" id="ENOG50330VF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPWILDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022261">
        <property type="entry name" value="RNP_Burkhold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="SSF56209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03795">
        <property type="entry name" value="RNP_Burkhold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="120" mass="13771" checksum="B7EE5FEC39A8EF08" modified="2004-10-25" version="1">MAENNAVPTHQSLLDFPEVYLRAIALSWENEQFKRELLADPLDALERYFDYRCPWILNLKVAEVPPDESHYGWDAKRQRWNLPVNTLRVGIPTPPKHLAEEGIALAAYNDAGPAYLFTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XJ8</accession>
    <name>Q63XJ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004548083.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107167.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0542"/>
    <dbReference type="EnsemblBacteria" id="CAH34531">
        <property type="protein sequence ID" value="CAH34531"/>
        <property type="gene ID" value="BPSL0542"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0542"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1106"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LQPECEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="30660" checksum="25FBA71F15123F58" modified="2004-10-25" version="1">MTFACIAAARRFDAAAHVPFAIAGRQVGWLRRGDVARLARWPDVFEFPAGRVELAARYDSVDARSMALASPIGALAAEGAIVGWRDEIYAIRNRFDDPPLAYIERAASRFFGTMTYAVHLNGIVEYAPSAPLAMWLGRRSATKATDPGMLDNVVAGGIGWGLGIEDTIAKECWEEAGIAAELAARAIPGRVAHVLRSLPEGTQAEQIFVYDLPLPRDFVPHNQDGEVAEHLLAGVDEIVAWLRAGEATVDASLAMLDSLLRHRAIAPEDARGIDALFAPPPLGLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XL0</accession>
    <name>HPRK_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPr kinase/phosphorylase</fullName>
            <shortName evidence="1">HPrK/P</shortName>
            <ecNumber evidence="1">2.7.11.-</ecNumber>
            <ecNumber evidence="1">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hprK</name>
        <name type="ordered locus">BPSL0530</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="1"/>
    <dbReference type="EC" id="2.7.4.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195225.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107155.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XL0"/>
    <dbReference type="SMR" id="Q63XL0"/>
    <dbReference type="STRING" id="272560.BPSL0530"/>
    <dbReference type="EnsemblBacteria" id="CAH34519">
        <property type="protein sequence ID" value="CAH34519"/>
        <property type="gene ID" value="BPSL0530"/>
    </dbReference>
    <dbReference type="GeneID" id="60547341"/>
    <dbReference type="GeneID" id="66546009"/>
    <dbReference type="KEGG" id="bps:BPSL0530"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1118"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMNNRQK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000067137" description="HPr kinase/phosphorylase">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="1">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <sequence length="322" mass="35165" checksum="16D1A692FE3CEFEF" modified="2004-10-25" version="1">MDTSSINAQSIFDDNAAMLKLSWLTGHEGWERGFSADTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR7</accession>
    <name>Q63XR7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195297.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107098.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0473"/>
    <dbReference type="EnsemblBacteria" id="CAH34462">
        <property type="protein sequence ID" value="CAH34462"/>
        <property type="gene ID" value="BPSL0473"/>
    </dbReference>
    <dbReference type="GeneID" id="56593838"/>
    <dbReference type="KEGG" id="bps:BPSL0473"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1182"/>
    <dbReference type="eggNOG" id="ENOG502ZCDP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESNHFAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="273" mass="29982" checksum="A9C60DDEB0476FC6" modified="2004-10-25" version="1">MNSITTTPNHLLDIVYPVLEGMAPGALQRALADAFDAESASLAQIEHAFNTLTSGKPPQEALRMFFASWSKTNNSAASVSGLANRVTLLARSDPGSPASARLYDVCASLQRITDEDLGALGGALHADLFYNMATTICGDDAWLLKSNCVASAQAFKDWTDRQRLRNRDLMQGLLTTLVHEVYTHGEVEFIHPLYKAWVEHRMNVPAERVRFVVAWVTVHTGGTESAHFAHAVRAIDTFCDAMDVRIDPASSTALFREYLRRKADVMRTCAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XT4</accession>
    <name>Q63XT4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein CtaG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX11/CtaG family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185071.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107081.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0456"/>
    <dbReference type="EnsemblBacteria" id="CAH34444">
        <property type="protein sequence ID" value="CAH34444"/>
        <property type="gene ID" value="BPSL0456"/>
    </dbReference>
    <dbReference type="GeneID" id="56594485"/>
    <dbReference type="KEGG" id="bps:BPSL0456"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1201"/>
    <dbReference type="eggNOG" id="COG3175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="SSF110111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="201" mass="21862" checksum="FC23681419A6D53B" modified="2004-10-25" version="1">MSKSEANVDRAFNRSMLLKLVVVAGLMFGFGFALVPMYRAICQITGINNLLQRDVSAREAKNTQVDYTRTVSIELDANARGPLGFKPRRNSIDVHPGELATVVYEVTNGQGRTVVAQAIPSYAPKQATEFFKKIECFCFTQQTLAANETRDMPVVFVIDPKLPKDVKTITLSYTFFELNTPAPAVKGAAVQTGGAAAKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y52</accession>
    <name>Q63Y52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106963.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0336"/>
    <dbReference type="ESTHER" id="burps-q63y52">
        <property type="family name" value="Hydrolase_RBBP9_YdeN"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34325">
        <property type="protein sequence ID" value="CAH34325"/>
        <property type="gene ID" value="BPSL0336"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0336"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.374"/>
    <dbReference type="eggNOG" id="COG3545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLERQFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="Hydrolase_RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="216" mass="23567" checksum="34EE557595F2107A" modified="2004-10-25" version="1">MQLREGHMRSCSKSTWPPRLVTAPGLHGSEGAHWQTWLERQFARALRVEQDDWDAPHVERWAQKVRDLLARERGPFVIAAHSFGCLATAHALAQAAQTRAADVVGVLFVAPANPRKFAFAGDFDARRLNVPSIVVGSESDPWMTLADAREFAQRLGSAFVNLGDAGHINTAAGYGPWPRAKYFVDTLVHCAAPLRLRDDDAPASGAPARQPLVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC7</accession>
    <name>Q63YC7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525893.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106888.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0261"/>
    <dbReference type="EnsemblBacteria" id="CAH34249">
        <property type="protein sequence ID" value="CAH34249"/>
        <property type="gene ID" value="BPSL0261"/>
    </dbReference>
    <dbReference type="GeneID" id="56527496"/>
    <dbReference type="KEGG" id="bps:BPSL0261"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1447"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LRIFMTK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="139"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="198" mass="21810" checksum="7E10480202F5B58F" modified="2004-10-25" version="1">MSESIARAPAPNPKRTLRETLARRRLDAQRAPRAHDALARRVLAILAQCAPRTVGFYWPLPGEFDARDAIASWLAGDASRQAALPVIGKPRTPLEFHAWTPDAPMREGRHRIAEPAAGARLVPELLLIPCVGFDHGCFRLGYGGGYYDRTLAAWPGATPPVTVGVAYDACGVRELPREAHDLPLDWIVTETRLYRSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YJ7</accession>
    <name>Q63YJ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPK2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189747.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106818.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0190"/>
    <dbReference type="EnsemblBacteria" id="CAH34177">
        <property type="protein sequence ID" value="CAH34177"/>
        <property type="gene ID" value="BPSL0190"/>
    </dbReference>
    <dbReference type="GeneID" id="56596688"/>
    <dbReference type="KEGG" id="bps:BPSL0190"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1529"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTHYENV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="4">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="32022" checksum="6E9BA798EBDC68B3" modified="2004-10-25" version="1">MAKQPSLDDYRVPYHTREKEAAAFTLDAFDPAAKPFSSGSKETDRERLSAVALQLDTLQERLHTQRHKRMLLVLQGMDSSGKDGTVRAVFHEVDPLGLRIVSFKAPTPVERSHDFLWRVHAQAPAAGELTIFNRSHYEDVLVPRVTAEIDKAECERRYRQIRQFEEMLAESGTRLVKCFLHISKDEQRARLQARIDDPNKHWKFDISDLEARKHWDAYQAAYRDALAATSAEHAPWYVIPADSKTHRNVMIAELLLRELTAMKLEYPPAKPELAGIQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YL1</accession>
    <name>Q63YL1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage-encoded membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106804.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34163">
        <property type="protein sequence ID" value="CAH34163"/>
        <property type="gene ID" value="BPSL0176"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0176"/>
    <dbReference type="eggNOG" id="ENOG5033NQW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="246" mass="27298" checksum="64BCC00CCDD35B8B" modified="2004-10-25" version="1">MDRFHGSSDGVGHRRTLVATPKGCEHVAALEELGAAVRCKSDRQRVNRDWAGAETKRGRMMNNISELNALLNLLGVAALLALLYGPIQSFIVDTVRQRFFEIRDGVFDAAAKGEIAFDDPHYVKFRASMNGLLRNAHECTIWRMVTLSIVGVKLFGKPSESDLNPFAEAPDFIKQAHQRATIWLGVLMWLRSPILIVLSMLGVLVIPVILIAATTSATARRLPLKLISTLQKDLRRDAALEVMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM3</accession>
    <name>Q63YM3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative phage-encoded membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0164</name>
        <name evidence="3" type="ordered locus">BPSS1071</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524440.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106792.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111082.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0164"/>
    <dbReference type="EnsemblBacteria" id="CAH34151">
        <property type="protein sequence ID" value="CAH34151"/>
        <property type="gene ID" value="BPSL0164"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38537">
        <property type="protein sequence ID" value="CAH38537"/>
        <property type="gene ID" value="BPSS1071"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0164"/>
    <dbReference type="KEGG" id="bps:BPSS1071"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1558"/>
    <dbReference type="eggNOG" id="ENOG5033ARY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RSQVSLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008473">
        <property type="entry name" value="Phage_holin_3_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05449">
        <property type="entry name" value="Phage_holin_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="90" mass="9721" checksum="250F25687FBA862B" modified="2004-10-25" version="1">MHVSSALVALAAHLAVIVRVLTYRKNGARHRFHVAWAAWVIVAISGGSAIELLFHPKPTGFFHAALAVLLAVLVYLARGNVARLLRSDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YN9</accession>
    <name>Q63YN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0148</name>
        <name evidence="3" type="ordered locus">BPSS1086</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531064.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106776.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111098.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0148"/>
    <dbReference type="EnsemblBacteria" id="CAH34135">
        <property type="protein sequence ID" value="CAH34135"/>
        <property type="gene ID" value="BPSL0148"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38553">
        <property type="protein sequence ID" value="CAH38553"/>
        <property type="gene ID" value="BPSS1086"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0148"/>
    <dbReference type="KEGG" id="bps:BPSS1086"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1573"/>
    <dbReference type="eggNOG" id="ENOG5032YUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HHVITLN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019289">
        <property type="entry name" value="Phage_tail_Gp41_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10109">
        <property type="entry name" value="Phage_TAC_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="114" mass="12006" checksum="A459B441593391C0" modified="2004-10-25" version="1">MTTIDTAHIETTGHAAPDENTHTLDTPIEREGQTITQVTLRKPAAGALRGTSLAALVNLDVDALRKVLPRISTPTLTEFDVAGMDPADLVALGGIFAGFLMPKALKASMESRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YQ8</accession>
    <name>Q63YQ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204748.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106757.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0130"/>
    <dbReference type="EnsemblBacteria" id="CAH34116">
        <property type="protein sequence ID" value="CAH34116"/>
        <property type="gene ID" value="BPSL0130"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0130"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1592"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWRYLCE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13362">
        <property type="entry name" value="Toprim_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="222"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="930" mass="102379" checksum="098BA0EB88049108" modified="2004-10-25" version="1">MATIDELKQRIDLHDLADRLGLKRGRGGDKALYHSPQHEDKSPSLSIYVNHPKHGTGWRDHSADAGGSCIDLVIHARGGTVADAVRYLHDAYGIPLDRPAPAERREKSTVEYIADRCLAERDRVREYLGGRGISAAAIDAAFAARSLGFNTWTSSKVAAGEVGHAGPAAAFIVREPADGRVVAVDMRYVDPALNGGVKTQTQGDKAGYGWTADARRLDKAKRIFIVESAINALSIDTCAMPGAAALALRGLANVDAIDFSSLRGKQVVICLDNDEPFADGHPRAGHRPGPEAAWALYERLASLNISAVLVDQAGWLADLADGETKQQPINDVNDYLQLRGPAELARALEQLEPWLIAGLAGDASRRGRPRIFLPSHDFAQYWRFRTRPDFTSYITKMDRNEESGVETPVMTDLCGFRIAGISRVSVASATSTMTGDADQAPTVYFAVSVQTPRHGAQLVRRVMLDDQLHNVDQWGKFGPIWAPAPFKRMVNILERGADLGARQAANFVGLAWRDGRLIVNEGPDCYFTEADKQCPYHNLTFPSGSTSDARRVITAYQTTFKQNAATIPLVWALGGHLKALLGFWPHITIQANKGAGKSTLIKRLERSLAFTMFSGQSLQTEFRLLTSISHTSHPVGWEELSARRQDVIDKAVGLLQENYQYTVTRRGTDMTEYLLCAPVMLAGEDVPVRSLLGKLVRTTLTGKRGPLLPDDLPRFPVRQWLEYLAGLDKRAVLEHYATLRDKALAKCIASGADDGANRMAANYAAVALAWRYLCEFAGMDPSEGGFPHDLLAEMNSHVAETSADREPWVWIMETVLSEIDGGNYKHPYTFDTVDGEFCLLLRTGHVMDHLAHTSALRDKWNGLPVKSDRVFKTQLKHAGVVVGEKEVERRIYTRRVPYLTPVSLERLAAFGLHVSVREDLATDALERSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR3</accession>
    <name>Q63YR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOL1/NOP2/Sun family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sun</name>
        <name evidence="7" type="ordered locus">BPSL0125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189046.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106752.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0125"/>
    <dbReference type="EnsemblBacteria" id="CAH34111">
        <property type="protein sequence ID" value="CAH34111"/>
        <property type="gene ID" value="BPSL0125"/>
    </dbReference>
    <dbReference type="GeneID" id="56596706"/>
    <dbReference type="KEGG" id="bps:BPSL0125"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1597"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IAYRTMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="196"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="284"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="50442" checksum="67EE0AD4A6049067" modified="2004-10-25" version="1">MTQTRPSRSRASGAPARAPRLSALHLVPDSLGFALDGAAQAVDAVDRGAALPAALAAVHAALPSNAQAASRGAIQDIGYRAMRRRGTADWLIAQLVAKAPPAHVHALLVCAFALLVDDEHAAYAPFTVVDQAVTAIGARRECSFAKGLVNAVLRRFLRERAAWLERLQADRRALWNYEPWWIDAVERAWPDAWQRILAAGDAPGPLTLRVNARRMTADAYLDTLRAERIDAEKIGLHAIRLASARPVERIPGFADGIVSVQDAGAQLSAEWLGARDGMRVLDACAAPGGKTGHILELAHAEVVALESDPARAPRIGENLARLSLTADVRVGDAADPAQWHDGRPFDRVLADVPCSASGIVRRHPDIRWLRRAADIPALVAEQRRILSALWPLVKPGGELLYVTCSIFPEEGELQARWFGDACQDAVRLDAPGQLLPQGATGGAPAVGGSGESGRHVDHDGFFYARFQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>H7C754</accession>
    <name>H7C754_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ADP-heptose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">waaE</name>
        <name evidence="2" type="ordered locus">BPSL2510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009921652.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109106.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2510"/>
    <dbReference type="EnsemblBacteria" id="CAH36517">
        <property type="protein sequence ID" value="CAH36517"/>
        <property type="gene ID" value="BPSL2510"/>
    </dbReference>
    <dbReference type="GeneID" id="56528671"/>
    <dbReference type="KEGG" id="bps:BPSL2510"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2871"/>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEFANAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02198">
        <property type="entry name" value="rfaE_dom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="307" mass="33153" checksum="8687D2131B8FC4C5" modified="2012-04-18" version="1">MSREQIAKSRVLVVGDVMLDRYWFGNVNRISPEAPVPVVHVQRQEERLGGAANVARNAVTLGGQAGLLCVVGRDEPGERIVELLGESGVTPYLERDPSLPTTIKLRVLAQQQQLLRVDFEASPTHEVLLAGLARFDALLPSYDVVLMSDYAKGGLTHVTTMIAKARAAGKPVLVDPKGADWARYRGASLITPNRAELREVVGRWTSEDDLRARVTKLREALAFDALLLTRSEEGMTLFSHEGELHVSALAREVYDVSGAGDTVIATVATMLGAGLPLVEAVVLANRAAGIVVGKLGTATVEYDELFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HT7</accession>
    <name>Q63HT7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529544.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112335.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2333"/>
    <dbReference type="EnsemblBacteria" id="CAH39819">
        <property type="protein sequence ID" value="CAH39819"/>
        <property type="gene ID" value="BPSS2333"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2333"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5970"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RHIIARR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="448" mass="48143" checksum="D8F8C1E1131B1CE7" modified="2004-10-25" version="1">MTTVFHRAPRASLPIAVAGDGIEIVDSTGTRYIDACGGAAVSCLGHSNQRVIDAIKRQAQQLPYAHTSFFTTQPAEALADRLVAAAPAGLEHVYFVSGGSEAIEAALKLARQYFVEKGEPARRHFIARRQSYHGNTLGALAIGGNAWRREPFVPLLIEAHHVSPCYAYREQRADETEEAFAQRLADELESRILALGPDTVAAFVAETVVGATAGAVPPVREYFRKIRAVCDKYGVLLILDEIMSGMGRTGYLFACEEDGVAPDLLTIAKGLGAGYQPIGATLVSDAIYRTIVDGSGFFQHGHTYVGHASACAAALEVQRVIDEERLLENVKARGEQLRASLAVRSAEQPHIGDVRGRGLFVGVELVRDRDTKAPFDPRLKLNALVKREAMQRGLMVYPMGGTVDGHLGDHVLLAPPFICTAPQIDTIVERLGDAIDAALASIGAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HX1</accession>
    <name>Q63HX1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552285.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112301.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2298"/>
    <dbReference type="EnsemblBacteria" id="CAH39784">
        <property type="protein sequence ID" value="CAH39784"/>
        <property type="gene ID" value="BPSS2298"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2298"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5919"/>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IEWHPFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="26378" checksum="8BEE386287573164" modified="2004-10-25" version="1">MSAGACHRSRDRGNRGDQLGDARPCKLTAECWFDFVCPWCWIGKRHLHAAVDALRALRPDVRAEIVWHPYRLLPDVPRGGLPYDAFYRARLGGGDAVDARRAQVRQAGREARLEFAFERIRTMPNTHAAHAFVDAAADAAHAARVDVDAMIERIFAAFFAHGRDIGDIATLECIALESGLPQHTLPSRLGRLPPRSPRPLGVAHRDIAGVPAFRFGGRETLSGARSPAVLLHAMLRSLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I26</accession>
    <name>Q63I26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112246.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2243"/>
    <dbReference type="EnsemblBacteria" id="CAH39729">
        <property type="protein sequence ID" value="CAH39729"/>
        <property type="gene ID" value="BPSS2243"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2243"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6676"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRATDMN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266889" evidence="2">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="3">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="16447" checksum="3F0AEDF1B619960C" modified="2004-10-25" version="1">MPRYTQPHSPHHAAKRFGRLATAVLIALAAACLALPQAAAAAGDGTGGAGAATGGANGSANGPNDMTGANTANRATDMNGASSSHSTSAGTKLRDTAITTKVKAALLATNDLSSGDIHVKTRRGAVQLAGTVPDERQRTLAVDVTRQVDGVKTVRDKLTVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I86</accession>
    <name>Q63I86_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112186.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2184"/>
    <dbReference type="EnsemblBacteria" id="CAH39669">
        <property type="protein sequence ID" value="CAH39669"/>
        <property type="gene ID" value="BPSS2184"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2184"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6600"/>
    <dbReference type="eggNOG" id="ENOG502Z9HB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLYPPTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="413" mass="44033" checksum="B068036AE298A76D" modified="2004-10-25" version="1">MDLANRGTCLRMSRSGGWLTSDRVLAYGGATLILSIALLGAWGWTTSGFTANTTVRPGIDFTVFWSGSHVMLHGAPASVYDYPAFSRAEAAQLGAYVNRSFLPWVYPPTLLVLVTPLALLRYLPSLLLFCALGLLAYAKSVGALTGLRDRLAKPRLASFVILSFPGVLVAAVIGQNSLLTAACAAFATRLLARRPALAGLCISLLAVKPQMALLFPLLLVATRAWRACFAAAAGTLVFAAASVAMCGTASVHAFLSGTTMLRELVLEQGTQYWLASPAPFSAMRLVGAPLRVAYAVQIGVGALAAAAALDVWLRTRDTRLRAAALAVATLLATPYLWHYELAWLGIALFGVLACALDTGWLPGEQPVFVAGWLLPFFEFFNRATHFPQIGPVVLLAVLLVVMRRARTMPGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ9</accession>
    <name>Q63IJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524842.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112073.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2070"/>
    <dbReference type="EnsemblBacteria" id="CAH39550">
        <property type="protein sequence ID" value="CAH39550"/>
        <property type="gene ID" value="BPSS2070"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2070"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VFALMPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="322" mass="33280" checksum="CA8D5EFB6159C99D" modified="2004-10-25" version="1">MERLLKIYLSKPEFAGGLMLILLAMLLQGTSGGVFLSGGNVGTVMGIVPEVGLVAVGVAILMIAGEFDLSVGSVFAFGPMVACVLAARGWPMAISMPAALLCCAAVGFLNGKLTLRFHIPSFITTLGMLFIVRSLTIVISGGFPPPFPDDAPVWLFTDTIGPVRLSMFWFLGLCVILALVLSVSNYGNWIRATGGMPEAAQSIGIRTDRVKLGCFVLCSVLAGFAGMLQVMRLASPLPSLGDGLELQAVAAAVIGGTALGGGIGTVLGAVIGVVLIRAIDNGMVVSGVDANWFKFAIGALTVAAVIANSHLRNVAKKMKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IL2</accession>
    <name>Q63IL2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ATP-binding inner membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540568.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112060.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2058"/>
    <dbReference type="EnsemblBacteria" id="CAH39536">
        <property type="protein sequence ID" value="CAH39536"/>
        <property type="gene ID" value="BPSS2058"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2058"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5602"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="21523" checksum="7FF5DC3E64713DD2" modified="2004-10-25" version="1">MTKKWKLTHWIMLGMILGIVVGYACHQYAADEATAKAIAADFGVVTTIFLHMVKMIIAPLVFATLVSGIASMDSGKSIGRIGAKVLGWFIVASLVSLSIGLLFVNIAKPGANLNMPLPPANASTHLQASALSVKEFYRCIGVVPVWRAQHLGLHSQALIFGECRGWLECRRRDSCVRNARVTNAATFARAKFKLMIGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IS0</accession>
    <name>Q63IS0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112002.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1996"/>
    <dbReference type="EnsemblBacteria" id="CAH39474">
        <property type="protein sequence ID" value="CAH39474"/>
        <property type="gene ID" value="BPSS1996"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1996"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6375"/>
    <dbReference type="eggNOG" id="ENOG5031DCT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FCTIYFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025421">
        <property type="entry name" value="DUF4148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13663">
        <property type="entry name" value="DUF4148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266069" evidence="2">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="14011" checksum="77A41D3CD015FDE5" modified="2004-10-25" version="1">MSIIEFPFWIRHRYGERMKATFLTVALAAAFVSPAAFADAPAGKTRAQVYQELVEAKANGLDYVTDASYPEISPLYAPRFANKAKPQQPAHAVADTRSDAKAGSSGNLSEAAQDEHCVGPRTFCNPYAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IU7</accession>
    <name>Q63IU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111975.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1969"/>
    <dbReference type="EnsemblBacteria" id="CAH39447">
        <property type="protein sequence ID" value="CAH39447"/>
        <property type="gene ID" value="BPSS1969"/>
    </dbReference>
    <dbReference type="GeneID" id="56529611"/>
    <dbReference type="KEGG" id="bps:BPSS1969"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5466"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASWTLKC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="532" mass="59363" checksum="09C58E28C92A9AFF" modified="2004-10-25" version="1">MSSTTDWNAARALDERAPQAATGGHARAKTDFDVLIVGAGLSGIGAAYYLRERCPDATYAILEGRETMGGTWDLFRYPGVRSDSDMFTLGFSFRPWHSDKAISDGQTILDYIRDTARAYGIDKTIRFGHKVTAASWDSTSARWTVRVQRATGDARHDEAVYTCRFLYMCSGYYDYEEGHAPSWPDMDAYQGRIVHPQHWPSDLDYKDKRVVVIGSGATAVTLVPSMAADARHVTMLQRSPTYIVSLPARDAIANALRRWLPSGLAHRLVRLKNVLLTMYFYNLARRRPDATKKFIVRAAGKQLGPQFDVNKHLTPRYKPWDQRVCLVPNGDLFKAIRAGRASIATDEIERFTPGGLRLKSGQRLEADVIVTATGLKLKMLGGAAVTVDGKPVDLSQTVSYKGMMYSGVPNLASSFGYTNASWTLKAELIAQYVCRLLEHMRTHGYDVCVPRLAPGSMELEPVVDLTSGYIQRAAGVLPKQGTKKPWKSYQNYARDFATFRFGPLADGAMQFERRRPALAERDDTRQPAYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH7</accession>
    <name>Q63JH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555084.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111745.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1739"/>
    <dbReference type="EnsemblBacteria" id="CAH39214">
        <property type="protein sequence ID" value="CAH39214"/>
        <property type="gene ID" value="BPSS1739"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1739"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6052"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFPITNW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="509" mass="56478" checksum="B67F980DACFFB0A5" modified="2004-10-25" version="1">MDTVILSDWLAARLERHSAEPMYRQLLRLMQQAILSGELTPGTKLPSSRTLATDLAIARNTVLHVYDQLTTEGYVLTTTGSGTYVADTRPDAAAMRAQAGAPAHPSDETRGAQQRAHGALSARGAQLIRHAGVSRRQWGAFMPGVPDVSEFPTRTWSRLQARLWKEANPELLTYAPGGGYRPLRRALSDYLRVARSVKCSPDQIIITTGIHQSIDLSVRLLADVGDRAWVEEPCYWGVRSVLQAAGLALAPVPVDQEGLAPRAQDLKRPPRLVLVTPSHQYPLGMVMSLARRRMLLEYARQHQCWIIEDDYDSEFRYGSRPLASLQGLDDAGRVIYVGSLGKMLFPSLRLGYMVVPEHLVETFRTGLSELYREGQLMQQAVLAEFIMDGYLTSHVRRMRALYGERRQLLIDAIHARFGDALPVMGDEAGLHLVIGLPNGCDDRAITQTAFDAGVIVRPLTTYYNHADTAREGLLLGYACVPNERIAPAFDTLAQIIEAHLNRRAKQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI0</accession>
    <name>Q63JI0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111742.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1736"/>
    <dbReference type="EnsemblBacteria" id="CAH39211">
        <property type="protein sequence ID" value="CAH39211"/>
        <property type="gene ID" value="BPSS1736"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1736"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6048"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWGMATA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="205"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="422" mass="45658" checksum="61306E592E03724F" modified="2004-10-25" version="1">MNTMTIATQSAPPTQSLRRELKAAEARRRTMALLLVAPLAIFLLLVFVVPIGALLTRAVQNPEIATALPRTVAALSNWDRKAAPADAAYAALAADLTQIADGEAMGALARRLNTEIPGYRSLVAKTARAMPLTGDANAPLAPAQTRAKLIELDERWGDAAYWQAIAKNGGRYSPFYLLAALDHKQDGFGSIVPADPDQSIYLAVFGRTLLIGFAVTLFALALGYPLAYWISTLPERRANLAMILVLIPFWTSVLVRVAAWIVLLQSEGLVNRALIDTGLISQPLALLFNRVGVYISMTHILLPFMILPLYSVMKSIPPSYQRAAVSLGSHPFAAFWRVYVPQTYPGVGAGALLVFILAIGYYITPALLGGPNDQMVSYYVAYFTNVTINWGMACALGGLLLAATLVLYAIYGRFTRSQLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JJ1</accession>
    <name>Q63JJ1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.79</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prpD</name>
        <name evidence="9" type="ordered locus">BPSS1725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17725"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="4.2.1.79"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940955.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111731.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1725"/>
    <dbReference type="EnsemblBacteria" id="CAH39199">
        <property type="protein sequence ID" value="CAH39199"/>
        <property type="gene ID" value="BPSS1725"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1725"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5142"/>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECTKHLG"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="7">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="8">
        <location>
            <begin position="287"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="483" mass="52504" checksum="57BAB51E72C959D4" modified="2004-10-25" version="1">MSAPIPNVRPAPDSVLVEIADYALNHRIDSALALETARHCLIDTLGCGLEALSYPACTKLLGPIVPGTIVPHGAKVPGTSLQLDPVQAAFNIGAAIRWLDFNDTWLAAEWGHPSDNLGGILATADWLSRTAVASGKRPFAMKDVLVAMIHAHEIQGCLALENSFNAVGLDHVLLVKVASTATVGCLLGLTRDELINALSLAFVDGQALRTYRHAPNTGSRKSWAAGDATSRAVRLALIAKTGEMGYPRALTAKTWGFYDVSFGGKPFRFQRPYGTYVMENVLFKISYPAEFHAQTAVEAAMTLHARLAAAGRTADEIRRVTVRTHAAAMRIIDKQGPLANPADRDHCIQYMIAVPLLFGRLTAADYEDAVAADPRIDALRAKIACVEDPQFTQDYHDPAKRSIANALTIEFDDGSTLAEVAVEYPIGHMRRRAEGMALLIDKFRTNLARRFPAKQQQAILDVSLDQAKLEAMPVDEYVDLYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JM5</accession>
    <name>Q63JM5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ordered locus">BPSS1692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525195.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111697.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1692"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="CAH39165">
        <property type="protein sequence ID" value="CAH39165"/>
        <property type="gene ID" value="BPSS1692"/>
    </dbReference>
    <dbReference type="GeneID" id="56529897"/>
    <dbReference type="KEGG" id="bps:BPSS1692"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5104"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="511" mass="56231" checksum="A66136B0AFEAC86B" modified="2004-10-25" version="1">MCGIVGVISQSPVNQLVYDSLLLLQHRGQDAAGIATADGSNFHMYKANGMVRDVFRTRNMRSLPGTAGIGQVRYPTAGSASSEAEAQPFYVNAPFGIILAHNGNLTNWQQLKDEMFRIDRRHINTNSDSEVLLNVLAHELQLSTTGLELDPDSLFKAVAGVHRRAHGSYAIVSLIAGYGLLAFRDPFGIRPLCIGKLETEQGTEWMVASESVAVEGIGFEFVRDVQPGEAVFIDVNGKFHSRQCADKPSLNPCMFEYVYLARPDSCLDGVPVYNVRLRMGDYLAEKIRRELPNVPIDVVMPIPDSSRPAAMQVAAKLGVEYREGFFKNRYVGRTFIMPGQAVRKKSVRQKLNAMSIEFKDKHVLIVDDSIVRGTTSHEIVQMARDAGAKSVIFASAAPPVKFPNVYGIDMPTRGELVAHGRTDEEVAKIIGADYLIYQDVGDLRRAVRDINPSLEGFEASCFDGDYITGDVTPEYLDAIERARLAPASQADRDPSGEGAERSQMNLQLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JN3</accession>
    <name>Q63JN3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipopolysaccharide biosynthesys-related glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111689.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1684"/>
    <dbReference type="EnsemblBacteria" id="CAH39157">
        <property type="protein sequence ID" value="CAH39157"/>
        <property type="gene ID" value="BPSS1684"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1684"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5094"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACMCAVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="96"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="240"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="450"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="634"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="820" mass="89861" checksum="43BD2D80EE48D5CB" modified="2004-10-25" version="1">MNRDLAEHPLQRAATFQDVERAARDARSADAPPPAHRARDAARPLRVAIVHDWLVTYAGAERVLEQIVACFPDADLFGLVDFLDDRTFLRGKPVTTSFIQRLPYARTKYRSYLPLMPLAIEQLDVSGYDLVISSSHAVAKGILTGPDQVHVSYVHSPIRYAWDLQHQYLEQSQLTRGVKSALARLILHYIRNWDVRTSNSVDRFVANSAFIARRIRKVYQRDAAVVFPPVDVDAFALSTRKEDFYLTASRMVPYKKIDLIVDAFAQMPGRRLVVIGDGPDMRKIRAKAAPNVEIMGYQPFAVLQDRMRRAKAFVFAAEEDFGISVVEAQACGTPVIAFGKGGALETVRDAASHERPTGVFFDEQSVRAIVAAVDDFERAPARFKPEDCRANAERFSAAHFRRRFVAQIDALLPNAQARAKLAGAMRPAGRASLAASGLRALVLDQSGVLGGAELSLLEIMKHLRESADVVLFDDGPFRAALDDAGVHVDVVGQRALAGVHKQGGVSLRAAGSLLALVREVARRARDADVIYANTQRAMVVGALAGRLARKPVVWHLRDIVSDAHFGPKQRLAIKQCARLGVTRVIANSDASARAFLELTGFERRAVQVVFNGISAEPFVALEPVRPAALRVRFGLPADAWIVGSFSRLAHWKGQHVLLEAARLYPDMHVALVGAPLFGEDEYAAELRGFVALHGLGERVHFLGFQRDVAACMKAVDVVAHTSITPEPFGRVIVEGMLAKRPVVAARAGGVVEIVDDDVNGLLCEPGDAHALADALAALRTDAVLCGRLVANGYDTAVNRFGTQIYVEQVERILVETARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW2</accession>
    <name>Q63JW2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT</name>
        <name evidence="3" type="ordered locus">BPSS1602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556283.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111610.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1602"/>
    <dbReference type="EnsemblBacteria" id="CAH39077">
        <property type="protein sequence ID" value="CAH39077"/>
        <property type="gene ID" value="BPSS1602"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1602"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4984"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVTHREV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="368" mass="41089" checksum="8150BE1134F60955" modified="2004-10-25" version="1">MNQHAAAAPLRDLAGEVLGLIDLKQMFTDIHIEQDRPVTIKTPRGWVETSDEPVLLDDMRPLLDAIDEHWESALRQGTLDRPFVLTRCRLRCHVYRAGGGRKIVISMRRLPLRPLPLEELGLPVYVRSMLDNTKGIILVTGPTGSGKTTTIASLLEHVNATRNTHIVTIEEPIEYYLERRQSIISQREVPTDTPNFPHGLREALRQKPDVVMVGEVRDAQTADTLLQAGESGHLVLATMHTGSAVSALNKLLSFFPVEQRDRHAVALAESLIGIVCQSLVPSADGESLVLASELLFNNNNQVAKLIADPAKLHLVNEFLRRREDNMSRSLNDDLAALAARNRITTKDALRATYNRLELHEMMQSIVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K09</accession>
    <name>Q63K09_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528837.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111563.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1557"/>
    <dbReference type="EnsemblBacteria" id="CAH39030">
        <property type="protein sequence ID" value="CAH39030"/>
        <property type="gene ID" value="BPSS1557"/>
    </dbReference>
    <dbReference type="GeneID" id="56530034"/>
    <dbReference type="KEGG" id="bps:BPSS1557"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4919"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYGSWIN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="16678" checksum="FDA1B4125194196D" modified="2004-10-25" version="1">MAIEVVELHHVGFRVAPEQADAMLDFYRDVLSLPLDRTRWKIPGIYGSWIDLPNGTQLHILGSDAPSRYAKGPGQDPVSNHIALAVEDVRAAEQTLVARGIGYFTLENIASPNLKQLFLHDPAGNLVELHQADARRPGITQADRQAPPVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K57</accession>
    <name>Q63K57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111515.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K57"/>
    <dbReference type="STRING" id="272560.BPSS1508"/>
    <dbReference type="EnsemblBacteria" id="CAH38981">
        <property type="protein sequence ID" value="CAH38981"/>
        <property type="gene ID" value="BPSS1508"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1508"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5762"/>
    <dbReference type="eggNOG" id="COG3521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VAGYYPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017734">
        <property type="entry name" value="T6SS_SciN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038706">
        <property type="entry name" value="Type_VI_SciN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12790">
        <property type="entry name" value="T6SS-SciN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03352">
        <property type="entry name" value="VI_chp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="225" mass="24218" checksum="6C01D3DB1A57098B" modified="2004-10-25" version="1">MLVALAALAGCAARVTEEQARADVRWDYAPDALRIDIDASARLNEYLNAPHTLLLAVFQSADAKAFRQLADDPDRLRMTLAAGGPAADFIQTTRYVVAPGQHVALSIDRAQQARYVGIVAGYYDADGPRAARLFEVPLRIDKRGWFSSTYRAAPRTLELKLRLGAQSITDAREAPLNLPPPGARAWTALDSGAKTLALPSADANEGGSGKRDKRGNAAARAPRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KG9</accession>
    <name>Q63KG9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AraC family regulator of pathogenicity genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551822.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111403.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1391"/>
    <dbReference type="EnsemblBacteria" id="CAH38866">
        <property type="protein sequence ID" value="CAH38866"/>
        <property type="gene ID" value="BPSS1391"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1391"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4715"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRIATCR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="380"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="483" mass="54741" checksum="53B56E6C6F694B6A" modified="2004-10-25" version="1">MFSMLYFPMVSALSLLGADAPTHLHSHLKLILGGEFNAALERSSEWAETTVASERTSWDLQLHADLQLVLGFEVEAEENYRRAQRKIRGSNSKIRIATCRNAAWQALFRYRVTTALACFSRICDEPGIEAGGLVEARFGIACALYEMGRIDDAFDAIDSMEKIAEQQSDEMRAYWKDLIAVLRFDLVVQSELRRVAAFVDHVYWQSAQSMSRVDRAHGVSEAAVSVETPLLRGRVAYLLQLRCAAAGNRDAVAELARCLDAAGEQGFVDFRYTLRLEIALALLAGDAPNLAQFVLEPISDTLHGAESSRRYREYFYCAAKVHLAQDHTQESLALYRRYALIAMRCLREDALIGRQFLVGQELKQLPQSDDVTVRLPLKYRRAYHYILQNLNRSDLSVREIAAEIGVTERALQNAFKIYLGLSPRELIRSRRMERIRTELVDFTLTGERNVKEAARKWGVQNGSTLVIAYRKEYDETPSETLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM5</accession>
    <name>Q63KM5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532072.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111346.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1336"/>
    <dbReference type="EnsemblBacteria" id="CAH38807">
        <property type="protein sequence ID" value="CAH38807"/>
        <property type="gene ID" value="BPSS1336"/>
    </dbReference>
    <dbReference type="GeneID" id="56530244"/>
    <dbReference type="KEGG" id="bps:BPSS1336"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5551"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFYDEHH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="18451" checksum="8BB5BCCA5452BBCB" modified="2004-10-25" version="1">MISIRLLEPADAAAFSALRLVAIDTSPSAIWPTRAEEAGRSMREVEARLRASGTQAVFGALTDDGGLIGIAGVRREALAQLAHKAVLWGVFVAPAHRGNGLARRLIDAALTHASRDWGVEQVNLCVNTENEPAKALYASLGFETFGVERRAMRVGDRFYDEQHMVRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP5</accession>
    <name>Q63KP5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940632.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111326.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1316"/>
    <dbReference type="EnsemblBacteria" id="CAH38787">
        <property type="protein sequence ID" value="CAH38787"/>
        <property type="gene ID" value="BPSS1316"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1316"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4611"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WSINAVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="162"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="312" mass="33444" checksum="3A5D3C25BC5B6A1C" modified="2004-10-25" version="1">MTQRLLAAAWRRPVWLLWVPPAFWAGNVVLGRAFSTSFPPVSLAVGRWLVALVALAPFVWRDVLRERWLLLRHWKLIWACGALGIAGYNALAYVALRTVPAASVAFLNSTLPLMVPLAAAMLGVERITSRAIVGIVVSFGGVAWIVARGHWEDLVALRFDHGELIVILATANYAIYSVLLRRKPAAIGPLAFLAATMATGLAVLAPFWALELAGGARIPFDPKAIGAVLYIGVFASLIAFILWGHCVQVLGATVTGVSFHLVALFTAVLAALTLGEPVRSYHLVGIALILFGFFVATRAAPGVRSAPNARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ5</accession>
    <name>Q63KQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ATP-binding ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551773.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111316.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1307"/>
    <dbReference type="EnsemblBacteria" id="CAH38777">
        <property type="protein sequence ID" value="CAH38777"/>
        <property type="gene ID" value="BPSS1307"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1307"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4598"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPMTRLD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="373"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="416"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH38777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="679" mass="72203" checksum="FD9B0A55D9153E8A" modified="2004-10-25" version="1">MSASRAAPSLPDARVLAVDGLTVTFRREDAAFVAVRDLSFHVDRGETLAIVGESGSGKSVTSLALMRLVEHGGGAIAGGAIALRRRGGAVLDLARATPSTLRTVRGADVAMIFQEPMTSLNPVFTVGDQISEAIALHQYKSAGEARAETLRLLDLVRIPEARRVFARHPHQLSGGMRQRVMIAMALSCRPALLIADEPTTALDVTIQAQILQLIRGLQDEMDMGVIFITHDMGVVAEVADRVLVMYRGEKVEEGACDAIFAAPSHPYTKALLAAVPRLGSMRGTDAPAKFPLLRFDPAAGDALVVAGGDATAASGDAARESVLFVDSDAAAASAASTASTASTVSTVSADSAASAAPTACARPAIDAGAPPLLRVRELVTRFPVKSGVFGRVSQYVHAVERVSFELRAGETLALVGESGCGKSTTGRSLLRLVERVSGSIEFEGREIGALKGRELQALRRNIQFIFQDPFASLNPRLTVGFSIMEPLLVHGVASGRQAQARVDWLLERVGLPADAARRYPHEFSGGQRQRIAIARALALNPKVVVADESVSALDVSVQAQIVNLMLDLQRELGVAYLFISHDMAVVERISHRVAVMYLGQIVEIGPRRAVFETPRHPYTKKLMSAVPIADPARRHAPRTLPADELPSPIRALGDEPEVAPLVAVGPAHFVAEHRVGGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L02</accession>
    <name>Q63L02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1211"/>
    <dbReference type="EnsemblBacteria" id="CAH38678">
        <property type="protein sequence ID" value="CAH38678"/>
        <property type="gene ID" value="BPSS1211"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|272560.6.peg.5382"/>
    <dbReference type="eggNOG" id="ENOG502Z9TZ">
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="DUF2875"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11394">
        <property type="entry name" value="DUF2875"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="512" mass="56017" checksum="44E7C5EA9DC98B03" modified="2004-10-25" version="1">MVGSIRNGMLVAAGVAIAAFVASFVWLKRAPVEPPHAAASSTSASPVLPAAATHGNNGAPALLAQTGEKFVLEVRGLGLVTGRNANDEIWNAIEAKADNHSTYMSQNPADYPDSEDSRMTYLGVGTGLSFQLAAHHSVGYWPVPVFIWEPPKALHVSRPANELSGIRQEASLGVTLLLWQQDANTDDGASIITELFTFFEAHPDVPEAVIYTLDGSMKRWLKDTPGYADTFGQSNIPTMPDSMVTLLVSRSDRVDRLIRPYAVEQTENVDKNTTEYDITKLWNFFWEKNNGEGPGSFEAYYQEQQKTAGIQPRAFLGFMSAQWWQTQLPAFWKTISNKGPGEFKPTPYIPVRWTTWQVRQFDNAPLLGYLHRPIDVKLADAHGKPLKTAQQAQALKAGWQQAVDTLPTGETPKRIFYDTTGDRAWVAPINQALAQSGPSAPSLDDVKEGYDIGRRIGNTGISSPLVQIGLGLIASYHEGGASATIHRRPNGTATIVMVSPPTHKQPDVNPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L30</accession>
    <name>Q63L30_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transmembrane antiporter Na+ or K+/H+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111191.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1178"/>
    <dbReference type="EnsemblBacteria" id="CAH38646">
        <property type="protein sequence ID" value="CAH38646"/>
        <property type="gene ID" value="BPSS1178"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1178"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5343"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAWATTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="50"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="449" mass="46859" checksum="97B567B67FD52BB2" modified="2004-10-25" version="1">MFRPRLCIVLTRLWRPNVGRDTNAVGSPAITPVEPRRIRMVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQIGLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGCLSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGPSHIVAGIAAFVLLAKLAARFVVTPLAADAAKRASPARLMSVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWLVPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGLVELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVRLWRRAVLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LV1</accession>
    <name>Q63LV1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205483.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110920.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0911"/>
    <dbReference type="EnsemblBacteria" id="CAH38373">
        <property type="protein sequence ID" value="CAH38373"/>
        <property type="gene ID" value="BPSS0911"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0911"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5010"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRSDWYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="497" mass="54210" checksum="63DFCFC225F1F4D6" modified="2004-10-25" version="1">MPERLAPSPRSPSMPFDPIVDMPAHTLAEAIRRKDVSCVETMRAYLAHIERVNTDVNAIVALREPDALLAEAAQKDAALARGEYAGWLHGMPQAPKDLAMTKGIVTTLGSPIFRTMTPSVDAIVVERMRAAGAVFIGKTNTPEFGLGSHTFNEVYGVTRNPYDLSKSAGGSSGGAAAALAARMLPVADGSDFGGSLRNPAAFCNVYGFRPSQGRVPRWPSVDVFVQQLGTEGPMGRTVVDVAQLLAIQAGYDRRDPLSLAEDPRRFTQSLDADMRGKRIAWVGDWNGYLAMEAGVLELCESSFDTLRAIGCDIDAALPAFPAERIWRSWLAHRHLLSGGNLLMHYREPSRRALLKPEAIYEAQGLFALGAADVYEASAARSAWYQALIAFFERFDYIAAPSAQVFAFDVELRWPQAIAGRAMDTYHRWMETVVPWTLAGCPVISVPVGFNAAGLPMGMQLIGRPRDDFAVLQLARAYEKERDWVSARPPALSGARND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LZ2</accession>
    <name>Q63LZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205479.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110879.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0870"/>
    <dbReference type="EnsemblBacteria" id="CAH38332">
        <property type="protein sequence ID" value="CAH38332"/>
        <property type="gene ID" value="BPSS0870"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0870"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7161"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVHVFAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="496" mass="52016" checksum="EEFEE0162CC5C780" modified="2004-10-25" version="1">MADWSGYSNAAAGSAAGGAGGRPALAAGAVGFPTALASAVGLIMASPVILTATSGFGMGGWAFAAAMLIAFVMMQAQATTFAEAAAMLPTAGSVYDYLSCGLGRFWAITGTISAYFLVHVFAGTAETILSGIMALVNFESLNAAFERHDSAWLVGVGLVATFAFTNIIGIKVFSKLEIVLTVGMWLSLTIFGVLGLVAAPAVQLDGWFGRSEIGASAPAVLSLVGMAMFMFVGCEFVTPLAPEMKTPGKTIPRAMALGLAGVAVCMFVYGAAIKRQVPNVAVTADGLTHLLDTPGAIPAFALQVLGPFGRAWFGIAFLCAGAATINTLMAGLPRILYGMAVDGALPKCFAYLHPRFRTPVVGIVAAAVVPIAHAWIIHGDLGSIMHLVLAATCAWGTAYLLVTLSVVMLRIRRPDLPRPYRSPWFPLPQIVSSVGIVLAIWYIAPPGTNSRDIYVPFGAMLGLTALYALFWTIVVQRKHPFRPVPVEEVLRNECVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MH9</accession>
    <name>Q63MH9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532900.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110692.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0679"/>
    <dbReference type="EnsemblBacteria" id="CAH38138">
        <property type="protein sequence ID" value="CAH38138"/>
        <property type="gene ID" value="BPSS0679"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0679"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6890"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRQWNTP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012368">
        <property type="entry name" value="OxRdtase_Mopterin-bd_su_IorB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036389">
        <property type="entry name" value="IOR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="743" mass="78028" checksum="A981012FC496EAF8" modified="2004-10-25" version="1">MTTDLDLPDAVRASRRTFLKAAGAAAAVGLTIGFEWLDASRPALGATAPAAPAGDAAGAFAPNAFLRVAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWRDVRVESAPADASRYANLQFGKLQGTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWNVPAAELTTGDGVVRHAASRREATYGSLATAAAALPVPEQVALKSPSDFRLIGKPVPRVDARAKSDGTAQFTIDVAMPGMLVALLQRPPVFGGKVKSFDASAAKAVPGVVSVVQVERGVAVVAKGFWAAKQGRDALKVEWDESGAEKRSSDAIMREYRQLAERPGASARRDGDAEHALAGAAKRLRASYEFPYLAHAPMEPLDAVVKLSADRCEIWAGDQFQTIDQGNAARVAGLDPSQVQIHTLYAGGSFGRRANAWSDYVVEAVSIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHRLDAALSKDGKLVGWRHRIVGQSILAGTPFEAVMVKNGIDQTSVEGAANLPYAIPNVSVELTTTRSAVPVLWWRVVGSSHTAYAVEAFIDEAAHAAGKDPYLFRRDLLAHAPRLKGVLELAAEKAGWDPGKPLPKGRGRGIAVAEAFKSYVAQVAEVSVDEHGAVKVERVVCALDCGTAINPDVIAAQMEGGIGFGLGAVLHGAITLKDGKVEQNNFDGYRVLRIAEMPKVEVYIVPSGEAPTGVGEPGVAPIGPAVANAIFAATGKRHYALPFPAAGEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MN1</accession>
    <name>Q63MN1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mmsA</name>
        <name evidence="4" type="ordered locus">BPSS0619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.27" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523210.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110640.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0619"/>
    <dbReference type="EnsemblBacteria" id="CAH38076">
        <property type="protein sequence ID" value="CAH38076"/>
        <property type="gene ID" value="BPSS0619"/>
    </dbReference>
    <dbReference type="GeneID" id="56530930"/>
    <dbReference type="KEGG" id="bps:BPSS0619"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4651"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VGAAKEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="25"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="509" mass="53933" checksum="C25AE8DB57572BDE" modified="2004-10-25" version="1">MNATPSSRKGHHVPTVKLLIAGEFVESHATEWRDIVNPATQELLARVPFSTVAEVGAAVEAAHAAFAKWKSTPISARMRIMLKFQDLVRANLPQIAKTLTAEQGKTLPDAEGDVFRGLEVVEHACSVGTLQLGEFAENVAGGVDTYTLRQPLGVCVGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLSTMQLVELAIEAGVPKGVLNVVHGGKEVVDALCSHPLVKAISFVGSTAVGTHVYRLGSEHGKRVQSMMGAKNHAVILPDANREQTVNALVGAAFGAAGQRCMATSVAVLVGAARDWLPDIVAKAKTLKVNAGAEAGTDVGPLVSRAAKQRVLGLIETGEQEGARLVLDGRGVSVPGYEHGNFVGPTIFADVRPEMSVYTHEIFGPVLCVMSVDTLDEAIALVNANPFGNGVGLFTQSGAAARKFQSEIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQVVQFYTQTKTVTARWFDDDATAGAVNTTIRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ4</accession>
    <name>Q63MQ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-54 activated regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530092.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110617.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0596"/>
    <dbReference type="EnsemblBacteria" id="CAH38053">
        <property type="protein sequence ID" value="CAH38053"/>
        <property type="gene ID" value="BPSS0596"/>
    </dbReference>
    <dbReference type="GeneID" id="56530952"/>
    <dbReference type="KEGG" id="bps:BPSS0596"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6772"/>
    <dbReference type="eggNOG" id="COG3284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTLGMVK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="325"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="646" mass="68948" checksum="56D6C14749B967B1" modified="2004-10-25" version="1">MPQSSVLPAAASRVDLLAQAHARSLSVGLRASELPDFSPLSRAALRELIDGSQSLYTHARPVMDTLHTQIADTQSLVLLTDRDGVILHSIGDADFVEKANRVALCPGVSWAEDARGTNAIGTALIAGQALAVHGAEHFLRANHVLTCSCAPIVDPFGRLLGALDVSGDPRGFSPHTLALVKMSAQLIENHLFANQCADALRVRFHAHDEFVDSLFAGLVAFSPSGALIAANRSAQFQLGANLDALQQRGCDELFGLSFAKLAQHAAREPLACFTLTLGTGVRVRARCEFAHAQRTAVAVSGRAAPPRATDAARDEEPDAITFATLDTGDARMTAVLQRVGKVRGRDLPVLVLGETGTGKEWLARALHHASPRRDGPFVAVNCAALPDSLIEAELFGYEDGAFTGARKRGSPGKIAQADGGTLFLDEIGDMPLAQQVRLMRVLQERAVMPLGGARAVPVDVRIVCATHRDLRAMIAAGTFREDLFYRINGLAVTLPPLAERSDLETLVARVLARLARSEPMPATVSAAVLAAFARCRWPGNLRQMTNVLRTAGMLAEGEARIDVEHLPDDFWLDCDARARDAAPPRTCADAAAGAAAAGASTLQDHQVALIDGALDRHRGNVSAAARELGLARNTVYRHLRRRRSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR6</accession>
    <name>Q63MR6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate mutase</fullName>
            <ecNumber evidence="1">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pchB</name>
        <name evidence="4" type="ordered locus">BPSS0582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.5" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543138.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110603.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0582"/>
    <dbReference type="EnsemblBacteria" id="CAH38039">
        <property type="protein sequence ID" value="CAH38039"/>
        <property type="gene ID" value="BPSS0582"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0582"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6757"/>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIHWFIN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009697">
        <property type="term" value="P:salicylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008241">
        <property type="entry name" value="Isochorismate_pyruvate-lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029775">
        <property type="entry name" value="Isochor_pyr_lyas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01803">
        <property type="entry name" value="CM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029775-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="11386" checksum="3720A696D1FFB672" modified="2004-10-25" version="1">MKTPDECTGLADIREAIDRLDADIIAALGARMQYVKAASRFKPTEASIAAPERVAAMLPDRRRWAEQAGLDGAFVEALYAQVIAWYIEQQTRHWRRQRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY0</accession>
    <name>Q63MY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530039.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110539.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0518"/>
    <dbReference type="EnsemblBacteria" id="CAH37975">
        <property type="protein sequence ID" value="CAH37975"/>
        <property type="gene ID" value="BPSS0518"/>
    </dbReference>
    <dbReference type="GeneID" id="56531033"/>
    <dbReference type="KEGG" id="bps:BPSS0518"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6678"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LHYWEQS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="19248" checksum="17C9800BDFA8B5C8" modified="2004-10-25" version="1">MANALVDYFLQIDGVEGESTDQQYPGLIQIQSWQWAEENSGRWGFGSGGGAGKVEMKDFEFRMVSNKASPKLFLMCATGEHIQNAKLICRKSGKGQQEFLTISFASGLVSSFRTLGNMPISQLGHASGEVDGVLPTDQIRINFAQIEFEYREQRNDGTMGAVIKAGYDLKQNAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY7</accession>
    <name>Q63MY7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004206084.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110532.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0511"/>
    <dbReference type="EnsemblBacteria" id="CAH37968">
        <property type="protein sequence ID" value="CAH37968"/>
        <property type="gene ID" value="BPSS0511"/>
    </dbReference>
    <dbReference type="GeneID" id="56597053"/>
    <dbReference type="KEGG" id="bps:BPSS0511"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6669"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMGGEPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="333" mass="34939" checksum="FC65EEF2D441EE15" modified="2004-10-25" version="1">MTRTGMILLSLGTAAFVALLAWQGLGAVAATLASAGWGLALVAAFHLVPLVIDATAIAVMFRPGEPGSRLGEALRARWVGEAVNSLLPAGQIGGPVLMVRYLAQRGARLADAAAAITVSTTMQALAQMVFALVGIAAFSAYATHDAAAHLRTPALIATAVLGGCAALFYCAQRRGLFGRGLRAASTLLGPRDWSSLATRADAIDHALDRLYRERAKVRATFVLSFVGWIVGTAEVWLALRFLGHPVSWLDALLLESVGQAIRGAAFAIPGSLGAQEGGYLLLAPLVGLPPDAALALSLAKRARELALGLPGLLYLHFSERNWQRRRAPQPIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N31</accession>
    <name>Q63N31_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="9">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">potG</name>
        <name evidence="9" type="synonym">potA</name>
        <name evidence="11" type="ordered locus">BPSS0466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="9"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525494.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110488.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63N31"/>
    <dbReference type="STRING" id="272560.BPSS0466"/>
    <dbReference type="EnsemblBacteria" id="CAH37922">
        <property type="protein sequence ID" value="CAH37922"/>
        <property type="gene ID" value="BPSS0466"/>
    </dbReference>
    <dbReference type="GeneID" id="56531083"/>
    <dbReference type="KEGG" id="bps:BPSS0466"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6613"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INNGEIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="384" mass="42201" checksum="B6B0CC52F561B52D" modified="2004-10-25" version="1">MKSTPSIDTAQLARPPVGTPAGTNEFVRIENVVKKFADSTAVDNVSLSIAKNELFALLGSSGCGKSTLLRMLAGLETATSGRIFVDGEDLATLPPYRRPVNMMFQSYALFPHMSVESNVAFGLKQEGTPKHEIRERVADALNLVQMSRYARRKPHQLSGGQQQRVALARSLVKRPKLLLLDEPMSALDKKIRQKTQLELVNIIEKVDVTCVMVTHDQEEAMTMASRLAVMSEGRIVQIGTPSQVYEFPNSRFSAEFIGSTNLFEGVVVEDEPDHIFVESEDLEARMYVSHGVTGPLGMPVGISVRPERVRVSRERPSAPHNWARGVVTDVAYMGSYSLYHVRLPSGKTVVSNLSSSHLMQDGAPAYNDDVFVSWSPASGVVLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N50</accession>
    <name>Q63N50_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529959.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110469.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37903">
        <property type="protein sequence ID" value="CAH37903"/>
        <property type="gene ID" value="BPSS0447"/>
    </dbReference>
    <dbReference type="GeneID" id="56531102"/>
    <dbReference type="KEGG" id="bps:BPSS0447"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6590"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAMPLDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="201" mass="21970" checksum="DC92423B3768A654" modified="2004-10-25" version="1">MNSHIAAVDLKKAYRLINHGPTVLVSAHHDGVDNVMAAAWACALDFSPPKLTVVLDKAAKTRELIEQSGRFVIQVPTAAQLQLTQEVGSHSLASRPDKLRRAGVELFSIDGHDAPFVAGCSAWLACTLVREPHNQQAYDLFIGEVDAAWSDTRAFKNGRWQFEQADPAWRSLHHVAGGHFYAIGEALSAREADRHDAEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N72</accession>
    <name>Q63N72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545573.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110447.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0423"/>
    <dbReference type="EnsemblBacteria" id="CAH37879">
        <property type="protein sequence ID" value="CAH37879"/>
        <property type="gene ID" value="BPSS0423"/>
    </dbReference>
    <dbReference type="GeneID" id="56531127"/>
    <dbReference type="KEGG" id="bps:BPSS0423"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6560"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FSFLEGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="451" mass="48129" checksum="3513306187A3C135" modified="2004-10-25" version="1">MKAFAAALGRLWHLGGIDLPVAVTLLARTWAIASGLVTVLLIARCLSPELQGYYYTFNSLVAMQIFAELGMNTVLVQCISHEMAELRIVGGRIAGERRTKARLKSLLTFGVAWCGGAACVFVAILLPGGWLFFGASAPHAPDIALAWGLFVVLTGVMLVLNGLLAFLEGCGQIGQVAAVRLAQAIGSSLGIWALLGARAQLLSFAGGLAIGCLIAAAALLARYRRLIVDLLRVNDAAGAVRWRTEIWPLQWRIAVSWASGYLIFNLFNPLLFATHGAVAAGRFGMSLQIVTALNSVGMAWITTKVPQFCRLIARRQRARLDELFRTTLRQSLFFLAAGGVLAVLVAALARPYAPWLGNRLVPVALFAALCVVCLANHVVFAEAAYLRAHKQEPFMIVSVANGLATALAAWALIPRWGAQGAVLAYAIGSVGVGFVGGTFVFVRKRAEFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N87</accession>
    <name>Q63N87_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110432.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0409"/>
    <dbReference type="EnsemblBacteria" id="CAH37864">
        <property type="protein sequence ID" value="CAH37864"/>
        <property type="gene ID" value="BPSS0409"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0409"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4399"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIAQNTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="2115"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2859"/>
            <end position="2879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="4131" mass="438098" checksum="FE283F5CDE48C92E" modified="2004-10-25" version="1">[encoded data, 4131 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N89</accession>
    <name>Q63N89_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110430.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0407"/>
    <dbReference type="EnsemblBacteria" id="CAH37862">
        <property type="protein sequence ID" value="CAH37862"/>
        <property type="gene ID" value="BPSS0407"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0407"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4397"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MYSPMER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="67"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="27434" checksum="F7A1198BE56ADE12" modified="2004-10-25" version="1">MRLYRSMYSPMERRALIEESPSFGYRTLAHLLGFNKNTVQRIFRLMGWQVRMRPIGFRPRVQAMPSVATAPNERGSTDMCRVWAGRDGWVTLARVIDCHTRELLGWHLSRSGRASTASSALEHARIARFGTLGRVPKPFLLRGDNGLVFTSRDYTALVRSYGLRQAFITPHCPQQNGMVERVIRTLKEQCVHRHRFETLQHASRAIADWIQFYNHRRPHQALKMKMPAEAFALCRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NF8</accession>
    <name>Q63NF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Shikimate 5-dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aroE</name>
        <name evidence="6" type="ordered locus">BPSS0341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.25" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531451.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110361.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0341"/>
    <dbReference type="EnsemblBacteria" id="CAH37789">
        <property type="protein sequence ID" value="CAH37789"/>
        <property type="gene ID" value="BPSS0341"/>
    </dbReference>
    <dbReference type="GeneID" id="56531198"/>
    <dbReference type="KEGG" id="bps:BPSS0341"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6460"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEHEGDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="5">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="29601" checksum="E01F9FF89A23432A" modified="2004-10-25" version="1">MSGRSFLIGLIGAGIGGSLSPAMHEAEGCGQGLNYVYRRIDLDALGLTADALPELLAAAERMGFDGLNITHPCKQRVIEHLDELSADAAALGAVNTVCFAHGRRIGHNTDWSGFAKAFARGLPGASLERVVQLGAGGAGAAVAHAALTMGAAQLALFDVDPVRARSLADQLQARFPHARLSAGGTLADALANATGLIHATPTGMLGHPGLPLPAHLLRSGLWVADIVYFPLETELIRAARALGCRTLPGGGMAVYQAVDAFELFTGRAPDAERMFEHFRALVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NR8</accession>
    <name>Q63NR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196059.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110251.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0231"/>
    <dbReference type="EnsemblBacteria" id="CAH37676">
        <property type="protein sequence ID" value="CAH37676"/>
        <property type="gene ID" value="BPSS0231"/>
    </dbReference>
    <dbReference type="GeneID" id="56596983"/>
    <dbReference type="KEGG" id="bps:BPSS0231"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6311"/>
    <dbReference type="eggNOG" id="ENOG50333Y3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FACKLDG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="94" mass="10417" checksum="A902507CCE2796C9" modified="2004-10-25" version="1">MAMKKTDLEKNKALKLTHAMKQTTSARFGKGAEDAAADRRERRRLEQAQGLVPFACKLNIELVARLNERAAAHPDGMTGLLTELLQRGLDETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NW8</accession>
    <name>Q63NW8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ImpA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205362.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110201.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0180"/>
    <dbReference type="EnsemblBacteria" id="CAH37625">
        <property type="protein sequence ID" value="CAH37625"/>
        <property type="gene ID" value="BPSS0180"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0180"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6242"/>
    <dbReference type="eggNOG" id="COG3515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAWSGEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010657">
        <property type="entry name" value="ImpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017740">
        <property type="entry name" value="TssA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37951">
        <property type="entry name" value="PTHR37951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06812">
        <property type="entry name" value="ImpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ImpA_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="381" mass="40633" checksum="84D7D13FD1D6A37F" modified="2004-10-25" version="1">MTPSRKPAGRAAAARTPKPDGWMAPVDAAAPCGADLEYDPEFVVLAAKVAPRAEAQYGDFVGSPEPVNWSDVERDCRRLMMRSKDMRLAVLFARSRTRLAGATGLAEGIGLLAAWLAAFPDAIHPQADVDADRDAALEIRRNALQALTDADGLLADVREIALTRSSATRLQVRDVERAFAQPRPGDALAPESVVRQLDDLHAQQPETLAGFGDALAGLAAIDAWSGEHLGDYAPDLSALDALLRRIAGANARGDRAEAEPIAPAEADAPPASEAAAAHAHAHAHAHAHAHAHAHASPPRRREPAAQALAAAIAGEPAAQPVDRYAARELIRQARQWFEQHEPSSPIPILLRRAEHFVGKRYADVVQAIPAELLALWSADET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NX3</accession>
    <name>Q63NX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110196.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0175"/>
    <dbReference type="EnsemblBacteria" id="CAH37620">
        <property type="protein sequence ID" value="CAH37620"/>
        <property type="gene ID" value="BPSS0175"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0175"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4116"/>
    <dbReference type="eggNOG" id="ENOG5030VXW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAQYWRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="239" mass="24702" checksum="D091B25AB9DE9490" modified="2004-10-25" version="1">MRAFKLFRRGPPDIERAETAARRDFEPSCAGVDMEGNAGDETGACLAEAQPPRAPQAGPQGATDGGDAVFGVIGAAFAADTPGERQGGMAAGASAVCGTVAAQDLLHTLYEQYCRVLDDPRASLASDDAARLAIERTRDAGPQIDPQRSADGADSIDALLSRARVLDDAFGTFAPGEAPDPADAEPVPEVLRLFAPAEYHAASARRPAGLPPALARREHQTLAIDSPLPAPVATSEHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ4</accession>
    <name>Q63NZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative D-amino acid dehydrogenase small subunit</fullName>
            <ecNumber evidence="2">1.4.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dadA</name>
        <name evidence="2" type="ordered locus">BPSS0154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.99.1" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196258.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110175.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0154"/>
    <dbReference type="EnsemblBacteria" id="CAH37599">
        <property type="protein sequence ID" value="CAH37599"/>
        <property type="gene ID" value="BPSS0154"/>
    </dbReference>
    <dbReference type="GeneID" id="56596898"/>
    <dbReference type="KEGG" id="bps:BPSS0154"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6208"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAGMRPA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="2"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="415" mass="44745" checksum="10A28891B4C6BCAC" modified="2004-10-25" version="1">MRICVLGAGVVGLTSAYCLAREGHDVTVLEARPDAVLDASFANGGQLSYSYVAPLADPAVLGKLPAWLARRDSALRFVPRLDVDQWLWCAAFLAACRTARARRTAAEMLELGALSRIALHALVERETLDFDYARNGKLVVYRDRREFDRARRAMDHLIAAGARQQALDTAACVALEPALAPASGLLAGGIHTPSEEVGDCRRFGIELARVLRERLRVAIHYETPVDTLRTEGATIVAARTPRGEIAADAFVLSAGNGSAPMLRRLGMRLPIYPLTGYSLTLPARHDATPRVSVTDLHRKIVYAPLGARLRIAGMVEIAGLRSSGAARRLALLAQQAQEIFPHAGDYAHGETWCGHRPATPDGKPLIGATPFRNLWLNTGHGALGFTLACGSARVLADLIAGRPPALDTRAYALHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P03</accession>
    <name>Q63P03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-independent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dbpA</name>
        <name evidence="10" type="ordered locus">BPSS0145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203996.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110166.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0145"/>
    <dbReference type="EnsemblBacteria" id="CAH37590">
        <property type="protein sequence ID" value="CAH37590"/>
        <property type="gene ID" value="BPSS0145"/>
    </dbReference>
    <dbReference type="GeneID" id="56531405"/>
    <dbReference type="KEGG" id="bps:BPSS0145"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6195"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
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    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="220"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="465" mass="50959" checksum="71B075177C1355A9" modified="2004-10-25" version="1">MTYPPTATPFSALALTPATLANLAQLGYTDMTPIQAASLPIALAGHDLIAQAKTGSGKTAAFSLALLARLDARRFDVQALVLCPTRELADQVAQEIRRLARAEENVKVLTLCGGTPMRPQTQSLEHGAHIIVGTPGRIMDHLDRGHLTLDALNTLVLDEADRMLDMGFFDDIAKVARQCPPTRQTLLFSATYPDGIAKLSQQFLRHPKRVKLEERHDDSKIRQRFYEVTEDERLHAVGLLLNHYRPVSTIAFCNTKQQCRDLLDVLHAQGFHALALHGELEQRERDQVLIRFANRSCSVLVATDVAARGLDIAQLEAVINVDVTPDPEVYVHRIGRTGRADQDGWALSLASMNEMGRVGGIEQALAREVEWHPLAELKAGGDAPLLPPMETLQILGGRKDKIRPGDVLGALTGDAGFSGAQIGKINVTEFSTYVAVERGIARDALRKLNAGKIKGKRVKVRLMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P48</accession>
    <name>Q63P48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523699.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110121.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0098"/>
    <dbReference type="EnsemblBacteria" id="CAH37544">
        <property type="protein sequence ID" value="CAH37544"/>
        <property type="gene ID" value="BPSS0098"/>
    </dbReference>
    <dbReference type="GeneID" id="56531454"/>
    <dbReference type="KEGG" id="bps:BPSS0098"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6127"/>
    <dbReference type="eggNOG" id="COG3517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAQSMQK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010269">
        <property type="entry name" value="T6SS_TssC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044032">
        <property type="entry name" value="TssC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044031">
        <property type="entry name" value="TssC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35565">
        <property type="entry name" value="PTHR35565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05943">
        <property type="entry name" value="VipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18945">
        <property type="entry name" value="VipB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03355">
        <property type="entry name" value="VI_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VipB" evidence="1">
        <location>
            <begin position="68"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="VipB_2" evidence="2">
        <location>
            <begin position="381"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="499" mass="56409" checksum="E213C710F4E516D8" modified="2004-10-25" version="1">MAARESQARSADAQLATHSDFNALLSREFKPKTEQAREAVEHAVKTLAEQALANSVTLSDDAYKSIEAIIGEIDRKLSEQINLILHHDDFQQLESAWRGLHHLVTNTETDEKLKIRFMDVSKDDLRRTMKRYKGVAWDQSPFFKQIYEEEYGQLGGEPYGCLVADYYFDHTPPDVDLLSSIGKVAAAAHAPFITGASPSVLQMDSWQELANPRDLTKIFTQNLEYAPWNSLRNSEDARYIGLAMPRFLARLPYGIRTNPVDEFDFEESTDGSDHRKYVWANAAYAMAVNINRSFKHYGWCTLIRGVESGGVVENLPCHTFPTDDGGIDMKCPTEIAISDRREAELAKNGFIPLIHRKNTDYAAFIGAQSLQKPAEYYDPDATANANLSARLPYLFACSRFAHYLKCIVRDKIGSFKEREDMQQWLNEWIMNYVDADPANSSQETKARRPLAAAEVVVEDVEGNPGYYQAKFFLRPHFQLEGLTVSLRLVAKLPSVKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PF8</accession>
    <name>Q63PF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative branched-chain amino acid ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL3418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195806.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110011.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3418"/>
    <dbReference type="EnsemblBacteria" id="CAH37430">
        <property type="protein sequence ID" value="CAH37430"/>
        <property type="gene ID" value="BPSL3418"/>
    </dbReference>
    <dbReference type="GeneID" id="56593918"/>
    <dbReference type="KEGG" id="bps:BPSL3418"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1768"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICGFDVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="28275" checksum="230E31980D02A17A" modified="2004-10-25" version="1">MILGDTILETRGLTKEFKGFTAVNGVNLRVRRGSIHALIGPNGAGKTTCFNLLTKFLKPTSGQIVYNGIDITDERPSQIARRGVIRSFQISAVFPHLSALQNVRIGLQRSLGTAFHFWRSERLLKRLDDRAMDLLTQVGLTDFAHVPTVELAYGRKRALEIATTLAMEPELMLLDEPTQGMGHEDVDRVTALIKKVANGRTILMVEHNMNVIAGISDTITVLQRGEVLAQGTYAEVSKNPLVVEAYMGSADAALAGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PH3</accession>
    <name>Q63PH3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ATP synthase protein I AtpI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524510.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109996.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3403"/>
    <dbReference type="EnsemblBacteria" id="CAH37415">
        <property type="protein sequence ID" value="CAH37415"/>
        <property type="gene ID" value="BPSL3403"/>
    </dbReference>
    <dbReference type="GeneID" id="56593903"/>
    <dbReference type="KEGG" id="bps:BPSL3403"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3871"/>
    <dbReference type="eggNOG" id="COG3312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAICWVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="176" mass="19018" checksum="7444A424EB2DA89A" modified="2004-10-25" version="1">MADRAPDKRHEDRRAAQRTVSGAVGRRAAAADDWDAEQQEDDVVPLTRAEAQALFGPEVSRPSRVTPYRVVVAQMVLSLVATLAWWLFSRSPGAAAQSAFLGGAIGWVPSALFVARLRLSGAGTVMGWVAGEALKLGVTIAMFAAVAFGYPGVHWVPLLVTYLVVLKTYWIALAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q48</accession>
    <name>Q63Q48_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">BPSL3176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196768.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109770.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3176"/>
    <dbReference type="EnsemblBacteria" id="CAH37187">
        <property type="protein sequence ID" value="CAH37187"/>
        <property type="gene ID" value="BPSL3176"/>
    </dbReference>
    <dbReference type="GeneID" id="56594188"/>
    <dbReference type="KEGG" id="bps:BPSL3176"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2062"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="39"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="285"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="423" mass="45221" checksum="C8B498609408D298" modified="2004-10-25" version="1">MTQAAFDYVDGTLHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGIAFDDARATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGGGLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAMYQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSLAIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANAHLVRPRETVESLFEHETILPEGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q87</accession>
    <name>HIS82_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol-phosphate aminotransferase 2</fullName>
            <ecNumber evidence="1">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazole acetol-phosphate transaminase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisC2</name>
        <name type="ordered locus">BPSL3138</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199913.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109731.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q87"/>
    <dbReference type="SMR" id="Q63Q87"/>
    <dbReference type="STRING" id="272560.BPSL3138"/>
    <dbReference type="EnsemblBacteria" id="CAH37148">
        <property type="protein sequence ID" value="CAH37148"/>
        <property type="gene ID" value="BPSL3138"/>
    </dbReference>
    <dbReference type="GeneID" id="56594090"/>
    <dbReference type="KEGG" id="bps:BPSL3138"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2105"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPDMACT"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000153339" description="Histidinol-phosphate aminotransferase 2">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <sequence length="356" mass="38142" checksum="6F985612DA171FE7" modified="2004-10-25" version="1">MTTPEDIIRRDVLAMTGYPVPDATGFVKLDAMENPYSLPAPLAAELGERLAHVALNRYPAPRPAALIDRLRAVTGVPAACDVLLGNGSDEIISMLAMACAKPGAKVLAPVPGFVMYELSAKFAQLEFVGVPLRADLTLDIDAMLAALAEHRPALVYLAYPNNPTGTLYPDEDVERIIAAAAASLVVIDEAYQPFAQRSWLPRAAQFDNVVVMRTMSKLGLAGIRLGYLVGLPAWLVQFDKVRPPYNVNVLTQAAAEFLLERVDVLDAQAAQLRDARTALAHAIGALPGATVFPSAGNFLLVRVPDAAAVFDVLLTERVLIKNVSKMHPLLANCVRVTVGSPEENARLLAALKLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QC7</accession>
    <name>Q63QC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage-related peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109691.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3096"/>
    <dbReference type="EnsemblBacteria" id="CAH37107">
        <property type="protein sequence ID" value="CAH37107"/>
        <property type="gene ID" value="BPSL3096"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3096"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3548"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYGYEMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_4" evidence="1">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="192" mass="22009" checksum="7314C519012E13E0" modified="2004-10-25" version="1">MIAIALRGRQLFQYDDTLRVPDEKIAALLKGEQLVPPLPLPPEVFATREVEQVRPALKDASRDWNLLDTDFRTRLLLVYKIMREQHGYEMALLEGYRSPERQNRLAQMGSNVTNAAAFQSYHQYGLAADNAFLRDGKLVISEKDPWAMRGYQLYGQVAEEVGLTWGGRWKMMDLGHVEYHKPGFKLGRSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QD8</accession>
    <name>Q63QD8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521971.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109680.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3085"/>
    <dbReference type="EnsemblBacteria" id="CAH37096">
        <property type="protein sequence ID" value="CAH37096"/>
        <property type="gene ID" value="BPSL3085"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3085"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2166"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWRHPIH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="35"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="33143" checksum="23B0A5FA8EC3279A" modified="2004-10-25" version="1">MSTKTYEIRPNQSIELLKELHILTRDGKMNQDSRRKLKQVYHLFQFIEPLLADVEREKGGVTLVDHGAGKSYLGFILYDLFFKARARADSHIYGIETREELVARSTELAARLGFGGMSFLNLSVADSIASPTLPETVDVVTALHACDTATDDAIRFALAKRARHIVLVPCCQAEVAGVLRRNKGKSLASALTEVWRHPLHTREFGSQITNVLRCLQLEAHGYQVSVTELVGWEHSMKNELIIAQYKNLPRRKPGERLDEILGMFGLAQLRERFFAPDTGTAGGAHAEPAAADAEPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R68</accession>
    <name>Q63R68_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">wzm</name>
        <name evidence="8" type="ordered locus">BPSL2805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194135.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109400.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2805"/>
    <dbReference type="EnsemblBacteria" id="CAH36814">
        <property type="protein sequence ID" value="CAH36814"/>
        <property type="gene ID" value="BPSL2805"/>
    </dbReference>
    <dbReference type="GeneID" id="56594705"/>
    <dbReference type="KEGG" id="bps:BPSL2805"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2503"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFRQVQP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="29216" checksum="7074B5330CADF1EC" modified="2004-10-25" version="1">MTNFGRSLAVQRRVIFALLMREVLTRYGRHNIGFLWLFVEPMIFTVGITILWNATGATHGSNLPISAFALTGYSTVLLWRNMPGRCSMAVTPNLALMYHRNVKVIDIFIARILLEVVGNTASFFVLMITFHALGLVDYPEDILEVMFAWVMIIWFGASLGFIIGALSEKTELVEKLWHPVTYLMFPLSGAIFMVDWLSPAFQKIVLWLPMVHGVEMLREGYFGSLVAAHYDIGYMACACLAMSLVGLALVRDVGREVTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC7</accession>
    <name>Q63RC7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109341.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2745"/>
    <dbReference type="EnsemblBacteria" id="CAH36753">
        <property type="protein sequence ID" value="CAH36753"/>
        <property type="gene ID" value="BPSL2745"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2745"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3135"/>
    <dbReference type="eggNOG" id="COG3791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTENMVA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="3">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16355" checksum="B96887CE9AF545BA" modified="2004-10-25" version="1">MPFLPASLCRVNRRFAMSSSESLEGGCACGAIRYRIVGTPNDAGFCHCRLCQRTTGAALIAWATVPIGAFEYVKGEPRVFVSSAWGERRFCPQCGAQLEYRRSDAPSTVEVNYATLDDPSAIAPKAHTWYASRIPGLEVAGGLPVRDDGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RE9</accession>
    <name>Q63RE9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Fe uptake system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109319.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2723"/>
    <dbReference type="EnsemblBacteria" id="CAH36731">
        <property type="protein sequence ID" value="CAH36731"/>
        <property type="gene ID" value="BPSL2723"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2723"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3105"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPRITWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="28715" checksum="57EA08408AB868E7" modified="2004-10-25" version="1">MPMSATLDIERLNWSPAGAGALLRELSLTVRAGELAGLIGPNGSGKTSALRCAFRFARPHAGTVTLDGRDVWRAPPRWSAQRIAVLQQEAPDDFGLTVEELARMGRTPHKRLFDADTADDARVVEAALRDVDLWALRERGFASLSGGEKQRALLARALVQQPALLLLDEPTNHLDVRHQLELLARVRALRVTTLATIHDLNLAAAYCDRLHVLAGGRIVASGAPADVLTRALIADVFGVDAIVDAHPVSGRPRVTLIYPEDAERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF9</accession>
    <name>Q63RF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527615.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109309.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2713"/>
    <dbReference type="EnsemblBacteria" id="CAH36721">
        <property type="protein sequence ID" value="CAH36721"/>
        <property type="gene ID" value="BPSL2713"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2713"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2619"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VNTAFMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="480" mass="48760" checksum="0BF91C0DF8385032" modified="2004-10-25" version="1">MTHGLHGPKRWYALVVLCLGVLMIVLDSTIVNVALPSIGADLHFTETALVWIVNAYMLTFGGCLLLGGRLGDLYGQRRMFLAGLTLFTLASLACGLAPTQFVLIAARAVQGFGGAVVSAVALSLIMNLFTEPGERAKAMGVYSFVCAGGGSLGVLLGGVLTSVLSWHWIFLVNLPIGVAAYALSAALLPKVRPQAADARLDVAGAIAVTASLMLAVYGIVNGNETGWLSTQTVATLAGAAALLAAFIAIETRAAHPLMPLALATQRNVAVANVIGVLWAAAMFAWFFLSALYMQRVLGYGPLQVGLAFLPANLIMAAFSLGLSARIVMRFGIRRAIGAGLVIAAAGLALFARAPADGGFVAHVLPGMILVGVGAGVAFNPVLLAAMSDVAPSDSGLASGIVNTSFMMGGALGLAVLASVASARTDALAAARAALPVALNGGYHAAFACGAAFAALAAGLAYALRIRAQSNAAAELHGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RH2</accession>
    <name>Q63RH2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185699.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109296.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2700"/>
    <dbReference type="EnsemblBacteria" id="CAH36708">
        <property type="protein sequence ID" value="CAH36708"/>
        <property type="gene ID" value="BPSL2700"/>
    </dbReference>
    <dbReference type="GeneID" id="56594980"/>
    <dbReference type="KEGG" id="bps:BPSL2700"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2635"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPNKEGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="15858" checksum="218D280D8AAC057F" modified="2004-10-25" version="1">MRPKRFDSKSGCSVEVTLSVIGGLWKPVILFHLLKEKKRFMELTRLMPNTTQRMLTLQLRELEADGIVARHVYPQVPPKVEYELTPFGKTLAPVLISLREWGDAYRTHQLGAGSASSAEPARGAASCDAPARPRSRAAGAMKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW7</accession>
    <name>Q63RW7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative siderophore receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL2553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550100.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109150.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2553"/>
    <dbReference type="EnsemblBacteria" id="CAH36561">
        <property type="protein sequence ID" value="CAH36561"/>
        <property type="gene ID" value="BPSL2553"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2553"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2815"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHPYPQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266544" evidence="7">
        <location>
            <begin position="30"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="70"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="323"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="778" mass="85218" checksum="CBF0D8D2F5E1C3A5" modified="2004-10-25" version="1">MFHQLAAPGARRRLAAACAAALAWPAAHAASTAAAVPADSTPAAAAEMTASGKTLDTVKVTAQRAAFAPDAPGVVEALTREQIDSHVNVTTEDALKYAPNLMVRRRYIGDRNSVFAGRDFNELQSARGLVYADGILLSNLLGSSYSYPPRWSLIQPDDIARVDVLYGPFSALYPGNAIGSTVQITTHKPQRLEASVSTQFFTQRYRDGYGFADSFGGNHQSARIADRVGRFWYALSLDRLENDSQPMQYASPNGAFDPRLGAPVPVTGAVSDIGPNGRPRTIVGAQTIERTEQLNETLRFGYAFTDHVDATVTLGHWENHYRQHGDTFLRDAAGNPVYGGNVSFGGRNYTVSPGAFAPQTGDQENWLYGLGLDARLASGWKLSATASAYEVSRDVLRSASGAPPGAWDGGPGTVFHGDGTGWRTVDLRAESPDVRGHRFSFGYHFDTYFLRNATYNTADWQNAVPTTLVNRYRGNTRTQALYAQDAWRVAPGWLATLGLRYERWDAYGGELGGATATLGYAERGATAFSPKLSLEWQPASAWRLRLSFATGTRFPTVAELFQGTISNNAIVNNNPNLQPEKAIDWDFTAERDVGFGVVRASVFQSDLRNSIYSQTTLAGASTYTNVSNVDRVRVRGVELAFSGQDVALKGLDVDANVSATNAQTLADAANPNYVGARWPRIPRMRANLLASYRFDEHWMTSVGVRYSGRQYNALDNSDVNPGVYGGTSSFMVVDLKARYRFDRHWLASFGIDNVTDRRYYVFHPYPGRTFYGELKWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RY2</accession>
    <name>Q63RY2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine deaminase</fullName>
            <shortName evidence="1">ADE</shortName>
            <ecNumber evidence="1">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Adenine aminohydrolase</fullName>
            <shortName evidence="1">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="3" type="ordered locus">BPSL2539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522340.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109135.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2539"/>
    <dbReference type="EnsemblBacteria" id="CAH36546">
        <property type="protein sequence ID" value="CAH36546"/>
        <property type="gene ID" value="BPSL2539"/>
    </dbReference>
    <dbReference type="GeneID" id="56528644"/>
    <dbReference type="KEGG" id="bps:BPSL2539"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2836"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DERLMQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="37500" checksum="44637D1585A70519" modified="2004-10-25" version="1">MTPTFKDKIARAPKAELHIHIEGSLEPELIFELAQRNGVKLAYESIDALRAAYAFTDLQSFLDIYYAGASVLLTEQDFYDMTAAYVERALADHVVHAEIFFDPQTHTERGVPIETVVAGIDRALADAEKRGFSSKLILCFLRHLSEESALATFDAALPLFDRYARRLIGVGLDSSERGNPPSKFARVFAKARERGLKLVAHAGEEGPPEYVTQALDVLKIDRVDHGVRSAEDAALVARLAGEKIALTVCPLSNLKLCVFDDLTKHTLKTLLDRGVAVTINSDDPAYFGGYVNENYFATVDALQLGEADVYTVIRNGFEASFVSADERAALIAKLDAHWHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S13</accession>
    <name>Q63S13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189725.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109104.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2508"/>
    <dbReference type="EnsemblBacteria" id="CAH36515">
        <property type="protein sequence ID" value="CAH36515"/>
        <property type="gene ID" value="BPSL2508"/>
    </dbReference>
    <dbReference type="GeneID" id="56596451"/>
    <dbReference type="KEGG" id="bps:BPSL2508"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2873"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFGHAYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267491" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="10419" checksum="585EAC63DBA4FB6E" modified="2004-10-25" version="1">MLKKLLATAALCAAAAHGWAAVDVNAANDDALRGIRGIGPAKAKAIVDERSAHGPFKDAADLARRVKGMGGKTVERLQAEGLAIGAARAPAAAGAPQKAAAAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S27</accession>
    <name>Q63S27_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938358.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109090.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2495"/>
    <dbReference type="EnsemblBacteria" id="CAH36501">
        <property type="protein sequence ID" value="CAH36501"/>
        <property type="gene ID" value="BPSL2495"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2495"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2887"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNTDCYQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="73"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="385" mass="43383" checksum="8F0AA7C562E4054C" modified="2004-10-25" version="1">MSERYDVEYPVMPPAPRKGRGAVGNLQGRYETVEREAVDDGWTRDDDGEPRAPLRTQVFEERARTILTRNASPDIPFNVSLNPYRGCEHGCIYCFARPTHSYLGLSPGLDFESRLYAKVNAAELLARELAKPRYVPEPIALGVNTDAYQPVERERRITRQVIQVMHDHGQPFAAITKSSLIERDLDLLAPMAERRQVMAAVTITTLDPELARALEPRAATPSRRLRTIRALRDAGVPVGVSIAPMIPFVTEPDLERVLEACADAGATHASYIVLRLPWEVAPLFTEWLAAHFPDRAERVMARVRDMRGGKDYDADFSRRMKGEGMWAELLKQRFRMAVKRCGLNERARGILDFSQFCAPRRSKPPPPVRPRAAAQTGDQPQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S62</accession>
    <name>Q63S62_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004205776.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109055.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2463"/>
    <dbReference type="EnsemblBacteria" id="CAH36466">
        <property type="protein sequence ID" value="CAH36466"/>
        <property type="gene ID" value="BPSL2463"/>
    </dbReference>
    <dbReference type="GeneID" id="56596379"/>
    <dbReference type="KEGG" id="bps:BPSL2463"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2927"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRMLYIH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022569">
        <property type="entry name" value="Fd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11953">
        <property type="entry name" value="DUF3470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="11913" checksum="36EB369BAE5DC299" modified="2004-10-25" version="1">MTHVVTEACIKCKYTDCVDVCPVDCFREGPNFLAIDPDECIDCAVCVAECPTNAIYAEEDVPGDQQHFTALNAELAKDWPSITKTKPAPADADEWKDVQEKLHLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SJ7</accession>
    <name>Q63SJ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192001.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108919.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2323"/>
    <dbReference type="EnsemblBacteria" id="CAH36326">
        <property type="protein sequence ID" value="CAH36326"/>
        <property type="gene ID" value="BPSL2323"/>
    </dbReference>
    <dbReference type="GeneID" id="56596122"/>
    <dbReference type="KEGG" id="bps:BPSL2323"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3100"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KTLWVNN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266753" evidence="1">
        <location>
            <begin position="26"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="330" mass="35897" checksum="F122BD62A2D9B5FE" modified="2004-10-25" version="1">MRNFLSLGRRLALAAAVLAPVAAFANNVIVLNSAEATLSLIDQQSRQVVGQYPTGKEPHHLMATPDNASLIVANSVSNSLMFLDPKTGKPQRTLEGIDDPYQLGFSPDRKWFVAAGLRLDRVDIYSYDGRDLKLAKRLPLAVMPSHLAFTKDSKTVLVSLQVSGELAAIDLATQTLKWKMKVGKVPAGLWLTPGDKYVLIGMTGADYVAVVDWRNQKVVKTIPTGKGAHNFRSLADGTHVAVTNRVANTISILDENALTNVGDITGLLPGPDDMELSADRKTLWVTFRFAKKVGVIDLPSRKLIQTISVGRSPHGIYFYDRAPWTAPNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SR3</accession>
    <name>Q63SR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524737.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108853.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2257"/>
    <dbReference type="EnsemblBacteria" id="CAH36260">
        <property type="protein sequence ID" value="CAH36260"/>
        <property type="gene ID" value="BPSL2257"/>
    </dbReference>
    <dbReference type="GeneID" id="56528932"/>
    <dbReference type="KEGG" id="bps:BPSL2257"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3174"/>
    <dbReference type="eggNOG" id="COG3317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DSMQELK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042268">
        <property type="entry name" value="BamC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010653">
        <property type="entry name" value="NlpB/DapX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06804">
        <property type="entry name" value="Lipoprotein_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266560" evidence="1">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="380" mass="41190" checksum="030F564CFE8DD79D" modified="2004-10-25" version="1">MKHSAFSSRAIQVSVLALALAALAGCDTLNDYLAPDRVNYKSTGSAPPLQVPQDLTAMPLSPSYVAPPTNSGLGSAPTRAVTAAGNATEGQPSAQDPFGMHVERDGDRRWLVVDGRTPEQLWPQLKEFWQDNGFALKTDAPSTGIMATDWAENRANIPDDWFRRTIGRVIDFAYSSGTRDRFRTLVTRTADGNTDISITHSAMEEKLTGAQGGTSSRWEERPRNPVLEAVFLAKLMEKFGLTDAQAKQLLADARPATAPATVVGSGAASTLDLAESFDRAWLRVGLALDRTNFTVDNRDRAKGVYYVRYANSMEELKRDGLFGKLFYGGPTAAKPGKEFLVNVRAQGDAKTQVAVIDANGQIDTSSDAQRIISLLHAQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SW2</accession>
    <name>Q63SW2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="9">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moaA</name>
        <name evidence="11" type="ordered locus">BPSL2209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205145.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108804.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2209"/>
    <dbReference type="EnsemblBacteria" id="CAH36211">
        <property type="protein sequence ID" value="CAH36211"/>
        <property type="gene ID" value="BPSL2209"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2209"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3237"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYCMSEN"/>
    <dbReference type="UniPathway" id="UPA00344"/>
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        <source>
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        </source>
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    <sequence length="329" mass="36272" checksum="ADFFBE2F1E55BA95" modified="2004-10-25" version="1">MARALVDRFGRAVTYVRLSVTDRCDFRCVYRMTQDMRFLPRSDVLTLDALAALARACVALGVRRIRLTGGEPLVRPGLTTLVERIARLPGLDELALTTNGARLAQFAAPLKAAGLARVNVSLDSLREDRFGALTRTGRLRDVPAGIAAAKRAGFRRIRLNCVILRGRNDDEVLDLVRFARAQRLDLAFIEEMPLGAIDEHDRASCFVSSDEVLARIRGRYALFPSDVSTGGPARYFRMADSEIRVGVIAPHSHNFCGDCNRVRVTASGRLLLCLGNEHGAELRDVLRTSPGDDARLRGAIAAAMPLKPERHRFDLDAPHIVRFMNMTGG</sequence>
</entry>
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    <accession>Q63SX8</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
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                <person name="Davis P."/>
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                <person name="Feltwell T."/>
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                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
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                <person name="Yeats C."/>
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                <person name="Parkhill J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">K96243</strain>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
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                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
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                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
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                <person name="Cronin A."/>
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                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
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                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
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                <person name="Whitehead S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">K96243</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="45" mass="5556" checksum="170D544F1497DAE3" modified="2004-10-25" version="1">MWNEKRFGYKMRSCAICTTWYIREYEEDAADMNVNLYQIVKNSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX6</accession>
    <name>Q63TX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Betaproteobacteria</taxon>
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            <taxon>Burkholderiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192710.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108440.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1841"/>
    <dbReference type="EnsemblBacteria" id="CAH35840">
        <property type="protein sequence ID" value="CAH35840"/>
        <property type="gene ID" value="BPSL1841"/>
    </dbReference>
    <dbReference type="GeneID" id="56595626"/>
    <dbReference type="KEGG" id="bps:BPSL1841"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3968"/>
    <dbReference type="eggNOG" id="ENOG50316J8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CIADEAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="12071" checksum="B47438904A3E6E32" modified="2004-10-25" version="1">MERLARLLPFRQFGRLRHLRGRTPCAPLVAAHSRDHADTQPSLLPSALPAFARVSLNGSLHHAEPARRAPVRVYHGPSRFIMVGTVDAICRMIDRCIAEERSLTQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U56</accession>
    <name>Q63U56_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobH</name>
        <name evidence="6" type="ordered locus">BPSL1760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EC" id="5.4.1.2" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521551.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108360.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1760"/>
    <dbReference type="EnsemblBacteria" id="CAH35759">
        <property type="protein sequence ID" value="CAH35759"/>
        <property type="gene ID" value="BPSL1760"/>
    </dbReference>
    <dbReference type="GeneID" id="56529445"/>
    <dbReference type="KEGG" id="bps:BPSL1760"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3861"/>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAPIFCD"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="208" mass="21367" checksum="07408F115A2B6AF0" modified="2004-10-25" version="1">MLDYLRDGRAIYRESFATIRAQADLTGVPPDLEKLAVRVIHACGMVDIVRDLRFSAGAGEAGRAALAAGAPILCDARMVAEGITRARLPASNPVICTLGDPEVPHLARELGNTRSAAALELWRAHLAGSVVAIGNAPTALFHLLDMIDAGAPRPALILGFPVGFVGAAESKALLAADSRGVPFVAIAGRRGGSAMAAAAVNALASEAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U72</accession>
    <name>OTCC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine carbamoyltransferase, catabolic</fullName>
            <shortName evidence="2">OTCase</shortName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arcB</name>
        <name type="ordered locus">BPSL1744</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521536.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108344.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63U72"/>
    <dbReference type="SMR" id="Q63U72"/>
    <dbReference type="STRING" id="272560.BPSL1744"/>
    <dbReference type="EnsemblBacteria" id="CAH35743">
        <property type="protein sequence ID" value="CAH35743"/>
        <property type="gene ID" value="BPSL1744"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1744"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3843"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYVKNWS"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112903" description="Ornithine carbamoyltransferase, catabolic">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <sequence length="336" mass="38017" checksum="470CDF2CA9D0FA6B" modified="2004-10-25" version="1">MSFNLHNRNLLSLIHHNARELRYLLDLARDLKRAKYSGTEQPRLLRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPASSQIGHKESMRDTARVLGRMYDAIEYRGFSQEIVEELAHHAGVPVFNGLTDEYHPTQMLADVMTMREHSDKPLHDIRYAYLGDARNNMGNSLLLIGAKLGMDVRIGAPKSLWPAADFIAQCEAFAAESGARLTLTEDPYEAVKGVDFIHTDVWVSMGEPVEAWDERINALLPYQVNRKLIESTGNPRTRFMHCLPSFHNCETKVGKQIAERYPHLKDGIEVTDEVFESPRCIAFEQAENRMHTIKAVLVSTLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U88</accession>
    <name>Q63U88_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative exported porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205056.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108328.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1728"/>
    <dbReference type="EnsemblBacteria" id="CAH35727">
        <property type="protein sequence ID" value="CAH35727"/>
        <property type="gene ID" value="BPSL1728"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1728"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3823"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NLRINHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266329" evidence="7">
        <location>
            <begin position="38"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="22"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="42437" checksum="32498A75E8E6E3A2" modified="2004-10-25" version="1">MSARAARQLPGNRRLARLAGAAAAACAAGFGASTAHAQSSVVLYGLIDTSITYANNQRTHGAGSPGSPGWAVTSGALNASRWGLRGREDLGDGVSAIFALENGFSGASGALSQKGVDMFGRQAWIGLKSKEGGALTLGRQYDLILDFVTPLGASGPGWGGNLAVHPYDNDDSNRNIRINNAVKYTSPTYRGWTLGAMYGFSNTAGPFGNNAAWSAGLSYANGPLKLGAGYLRINRNPNAANANGALSTTDGSATITGGSQQIWAVAGRYAFGPHSIGAAWSHSATDRVSGVLQGGSIAKLDGNSLVFDNFTLDGRYVVTPRLSLAAAYTYTMGRFDARSGETRPKWNHMVAQADYAFSIRTDAYLAAVYQRVSGGNGIPAFNATIWTLTPSANGNQVVVALGLRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB9</accession>
    <name>Q63UB9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2063 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521491.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108297.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1690"/>
    <dbReference type="EnsemblBacteria" id="CAH35689">
        <property type="protein sequence ID" value="CAH35689"/>
        <property type="gene ID" value="BPSL1690"/>
    </dbReference>
    <dbReference type="GeneID" id="56529388"/>
    <dbReference type="KEGG" id="bps:BPSL1690"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3770"/>
    <dbReference type="eggNOG" id="COG3219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MARFHIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018640">
        <property type="entry name" value="DUF2063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044922">
        <property type="entry name" value="DUF2063_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09836">
        <property type="entry name" value="DUF2063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2063" evidence="1">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="27814" checksum="6792C423EAC8A5F9" modified="2004-10-25" version="1">MRSDAAASDYACAFAPGLTNPSIGAPDDAIAHGHKRVARRYDVYRNNVTVSLIEALAAIYPAVQRIVGVEFFRAMARFHVRETLPVSPLLFEYGRDFPDFIAGYEYARTMPWLADTARIERAWLDAYHAADLSTLTADAFTAIPPDALAAVRLVPHPATRIVRSPYPAVSIFAMNRSDGPVTSLHSAEAEDALVTRPAHDVIVSRLPLGGAVFLISLIDGASLGDAVAITLEDNPAFDLPASLRGMIEAGVFTAIHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UJ2</accession>
    <name>Q63UJ2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL1608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527101.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108224.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1608"/>
    <dbReference type="EnsemblBacteria" id="CAH35608">
        <property type="protein sequence ID" value="CAH35608"/>
        <property type="gene ID" value="BPSL1608"/>
    </dbReference>
    <dbReference type="GeneID" id="56529330"/>
    <dbReference type="KEGG" id="bps:BPSL1608"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3668"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRVGIQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="352" mass="37319" checksum="1704374313ABD298" modified="2004-10-25" version="1">MPGLKKLVGSSLALAVVVTLMAWLALRSPQVYVQGTYVFGTRVQLALYGVPLDRAQQATNAVFAHFQAMQRGLHAWQPSEITRLNRSIAAGEPFRASPATAEILRAARRLSLDTQGLFEPGIGRLIRLWGFQSDQFRVAPPSPDAVRRELARGARIADLAISPDGVVTSANRAVAIDLGGFAKGWALDDAAAILRRQGIANALIDVGGNLLALGSKGGAAWRVGVQDPRKPGTLATLELRDGEAIGTSGDYERFFQAEGVRYCHLIDPRSGFPAVQSEAVTVLVAPGPHAGALSDGASKPPFIAGRAAMPLARRLGVQAVLIVDAQGRVWATDAMAARARFADPALRAARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UP6</accession>
    <name>Q63UP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative betaine aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527142.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108170.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1550"/>
    <dbReference type="EnsemblBacteria" id="CAH35551">
        <property type="protein sequence ID" value="CAH35551"/>
        <property type="gene ID" value="BPSL1550"/>
    </dbReference>
    <dbReference type="GeneID" id="56529275"/>
    <dbReference type="KEGG" id="bps:BPSL1550"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3595"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGGHYSF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="478" mass="50484" checksum="9660FA773F3EAB52" modified="2004-10-25" version="1">MKTCEQFYIGGAWRPSTGKGMIDVIDSGTEAVIGRVPEGTAEDAKAAVAAARAAFDGWAATPPAERARYLHKITENLKARSEELAQSITGEVGMPIKLSRAIQVGGPIYNWGAYAKLAETFAFEEQVGNSLVVREPVGVVAAITPWNYPLNQITLKVAAALAAGCTVALKPSEVAPLNAFILAEAIHDAGLPAGVFNLVCGYGPVVGEALASDADVDMVSFTGSTRAGKRVAELAAAGVKRVALELGGKSASVILDDADFAAAVKGTVSACYLNAGQTCSAHTRMLVPESRYEEARDLAKAAAQAYVAGDPRDDATRLGALASSVQQKRVQDYIRRGIDEGAELVTGGLGMPEGITRGFFVKPTVFGRVKPDATIAQEEIFGPVLSILTYRDEDDAVRIANDSPYGLGGAVWAGSDERAMRVARRIRTGQVDINGGAWNMAAPFGGFKQSGIGRENGVYGLDEYLEYKSMQLRPHKRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UT2</accession>
    <name>SYH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">BPSL1514</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521334.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108134.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UT2"/>
    <dbReference type="SMR" id="Q63UT2"/>
    <dbReference type="STRING" id="272560.BPSL1514"/>
    <dbReference type="EnsemblBacteria" id="CAH35515">
        <property type="protein sequence ID" value="CAH35515"/>
        <property type="gene ID" value="BPSL1514"/>
    </dbReference>
    <dbReference type="GeneID" id="56529238"/>
    <dbReference type="KEGG" id="bps:BPSL1514"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3551"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136130" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="446" mass="49628" checksum="B9DF1AEEFEEFF816" modified="2004-10-25" version="1">MTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEERAAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSRAHFDGLQRLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGVERILELLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVANGTVSVKPLRGTGAEGEKNVQQSVPVESLTEFLINAMVATAEDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V12</accession>
    <name>Q63V12_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192469.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108054.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1432"/>
    <dbReference type="EnsemblBacteria" id="CAH35434">
        <property type="protein sequence ID" value="CAH35434"/>
        <property type="gene ID" value="BPSL1432"/>
    </dbReference>
    <dbReference type="GeneID" id="56595832"/>
    <dbReference type="KEGG" id="bps:BPSL1432"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3454"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHVEMRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="15787" checksum="CC2682EB35C48B8D" modified="2004-10-25" version="1">MESIEIETGDWSRLGGDASRIRDAVFVREQRIPAELDLDDDDPHARHAVAYLVDGTAGARRAVATGRLLPTGAIGRVSVLADARGRGVGSRLLDALLAEARGRGDALVRLYAQQRAVAFYLRIGFRIVGEPFVAAGVQHIEMAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V76</accession>
    <name>Q63V76_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197666.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107990.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1365"/>
    <dbReference type="EnsemblBacteria" id="CAH35363">
        <property type="protein sequence ID" value="CAH35363"/>
        <property type="gene ID" value="BPSL1365"/>
    </dbReference>
    <dbReference type="GeneID" id="56595292"/>
    <dbReference type="KEGG" id="bps:BPSL1365"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.115"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRFWRGS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021766">
        <property type="entry name" value="PhoR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014310">
        <property type="entry name" value="Sig_transdc_His_kinase_PhoR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11808">
        <property type="entry name" value="PhoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02966">
        <property type="entry name" value="phoR_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="213"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="436" mass="49063" checksum="714C5CB97F73CA2B" modified="2004-10-25" version="1">MNIIWARFLVSLVLLALVSVIIGAIAGPVPGLVFALAMLVVQGFVSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDRDQIEWCNAIAEVHFGLDAKRDLRQHVTHLVRHPDFVRYLNGQHYDETLVMRGMGGNRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLSDDERARYLELMEQQASRMRHIVTDLLVLAKLEGESKPPADRAVDMRTVLDHLRDDAQTLSGGHHEITFKVDETLAVTGAQTEIFSALGNLVTNAIRYTPEGGTIRVEWRRDGAQAVFSVTDSGLGIPAAELPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAQLSIQSEEGRGSTFTARFPAHRTISRRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VG7</accession>
    <name>Q63VG7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC transport system, iron-binding exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550682.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107899.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1278"/>
    <dbReference type="EnsemblBacteria" id="CAH35272">
        <property type="protein sequence ID" value="CAH35272"/>
        <property type="gene ID" value="BPSL1278"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1278"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.232"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HPYNVSL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267616" evidence="3">
        <location>
            <begin position="33"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="37517" checksum="6B8C881E0E5C652B" modified="2004-10-25" version="1">MFVKQARPLLRTLLRPLAFAFALAAVAPAAHAANEVNLYTTREPKLIQPLVDAFTKQSGIAVNTVFVKDGLLERVKAEGARSPADVLMTVDIGNLLDLVDGGLTQPVRSASLDGAIPANLRGAGGNWYALSLRDRVLYVDKNMQLDAITYESLADPKWKGKVCIRSGQHPYNTALVAAMIAHDGEAAAEQWLRGVKANLARKATGGDRDVARDILGGICDIGLANAYYAGHMKHAQPGTDARKWGDAIKVVRPTFANAKSGGTHVNVSGAAVAKHAPNRDNAVKLLEYLASPPAQALYAQANYEYPVRAGVALDPVIAGFGPLKVDPLPLVEIAKYRKRASQLVDKVGFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VK6</accession>
    <name>Q63VK6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107860.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1239"/>
    <dbReference type="EnsemblBacteria" id="CAH35233">
        <property type="protein sequence ID" value="CAH35233"/>
        <property type="gene ID" value="BPSL1239"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1239"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1370"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SQGANQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="384" mass="42177" checksum="1994970B94B86B96" modified="2004-10-25" version="1">MPTTPTLLSRLPEVGTTIFTVMSALAAEKGAVNLGQGFPDFDCDPRIVDAVAHAMRDGRNQYPPMAGVAPLREAIADKIERLYGRRYDAATEITVTAGATQALLTAILCAVHPGDEVIVIEPTYDSYLPSIELAGATPVFVTLNAPDYAIPFDKLAAAITPKTRAILINTPHNPTGTVWREADMRALEDIVRGTGLLIVSDEVYEHMVYDGARHESVARYPELAARSIIVSSFGKTFHVTGWKIGYVAAPAPLTAEFRKVHQFNVFTVNTPMQFGLADYLRDPEPYLTLPAFYQQKRDFFRAGLANTRFALLPCAGTYFQCVDYSAISDLPEAEFAKWLTTEIGVAAIPVSAFYHEPHESGVVRFCFAKREDTLATALERLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VR6</accession>
    <name>Q63VR6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185803.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107800.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1178"/>
    <dbReference type="EnsemblBacteria" id="CAH35173">
        <property type="protein sequence ID" value="CAH35173"/>
        <property type="gene ID" value="BPSL1178"/>
    </dbReference>
    <dbReference type="GeneID" id="56595109"/>
    <dbReference type="KEGG" id="bps:BPSL1178"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.354"/>
    <dbReference type="eggNOG" id="ENOG502Z9HI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WASGINL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="205" mass="21152" checksum="67216B40EBF4D59F" modified="2004-10-25" version="1">MVEAISLGAGLAWASGLRLYLTVLIAGVFARAGFIHLPDTLAVLTSPWVIGSAAVLAVAEFLADKVPAFDSLWDAVHTFIRIPAGAVLAAASLGHADPALLVVAGLAGGTLAGSAHIAKAGTRALINLSPEPISNWIASTTEDGLTVGGLVLAFFVPLLFLALMIGFLAFSAWALPRLWRGVSGGFRGMANHMVSRLNSIGSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VR8</accession>
    <name>Q63VR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196449.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107798.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1176"/>
    <dbReference type="EnsemblBacteria" id="CAH35171">
        <property type="protein sequence ID" value="CAH35171"/>
        <property type="gene ID" value="BPSL1176"/>
    </dbReference>
    <dbReference type="GeneID" id="56595107"/>
    <dbReference type="KEGG" id="bps:BPSL1176"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1300"/>
    <dbReference type="eggNOG" id="COG3042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NCTQRGG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005590">
        <property type="entry name" value="DUF333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03891">
        <property type="entry name" value="DUF333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266809" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="98" mass="10445" checksum="1195C6FC30D403EE" modified="2004-10-25" version="1">MLVRLLFGCALGIAAATALAQPLPPNQSTTLANPASVNCEKLGGKVVIHDGPRGQFGICAFKDGRECEEWALYRDDRCVQLDAHGWPIAQRGGKPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX8</accession>
    <name>Q63VX8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaE</name>
        <name evidence="12" type="ordered locus">BPSL1117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522462.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107738.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1117"/>
    <dbReference type="EnsemblBacteria" id="CAH35110">
        <property type="protein sequence ID" value="CAH35110"/>
        <property type="gene ID" value="BPSL1117"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1117"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.431"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NECRRMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="11">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130098" checksum="935D51A2FCEE3D7C" modified="2004-10-25" version="1">MSDPRFVHLRVHSEFSIADGIVRLDDIVKSAAEDGQGALALTDLGNAFGLVRFYKEARDAGIKPIAGCDVWITNHDDRDKPSRLLLLVKDKRGYLNLCELLSKAWLTNQYRGRAELDASWLEGELAEGLLALSGAQQGDIGLALAAGNEAAARRHAQRWARVFPGGFYIELQRYGQPGAEAYIQQAVAIAAELKLPVVATHPLQYMTADDFTAHEARVCISEGDILANPRRQKRFTTEQFFRTQGDMAALFADLPSALANTVEIAKRCNLTLELGKPKLPRFPTPDGMSLDDYLVQLSQEGLDKRLVQLYPDEAEREAQRGKYNQRLDFECGTIKKMGFPGYFLIVADFINWAKNNGVPVGPGRGSGAGSLVAYSLGITDLDPLRYNLLFERFLNPERVSMPDFDIDFCQHGRDRVIQYVKEKYGADAVSQIATFGTMAAKAAVRDIGRVLDLGYMFTDGVAKLIPFKPGKHVTIADAMKEEPLLQERYDNEDEVHQLLDLAQRVEGLTRNVGMHAGGVLIAPGKLTDFCPLYTQGDEGGVVSQYDKDDVEAVGLVKFDFLGLTTLTILDWAERYIRRLDPSKENWSLAQVPLDDPTSFQILKKANTVAVFQLESRGMQGMLKDAQPDRFEDIIALVSLYRPGPMDLIPSFCARKHGREKVDYPDPRVEPVLKETYGIMVYQEQVMQMAQIIGGYSLGGADLLRRAMGKKKPEEMAKHREIFAEGAAKNGLTREKSDEIFDLMEKFAGYGFNKSHAAAYALLAYYTAWLKAHHPAEFMAANMTLAMDDTDKVKILFDDCLVNGLAVLPPDINRSNYRFEPVAEADGKRSRTIRYGLGAIKGSGQNAIEEILRAREEKPFADLFDFCERIDRRVVNRRTIEAMIRAGAFDSLHENRAQLLASVPLAMEAAEQAAANALQAGLFDIGGVPAHQHALVDEPAWDDKRRLQEEKGALGFYLSGHLFDAYRDEVRRFVRQKLGELKEGRDKVVAGVIASLRTQMTQRGKMVIALLDDGTGQCEVTVFNEQFDANRALFKEDELLIVQGQARNDAFTGGIRFTAESVMDLERARSRYAQAVRMTMNGNADAAALRRVLEAHVAKPDETPPAAAPAPRGGRDGGRRAQAAIPNGLAVRIAYSNARAQGEMRLGDAWRVKPSDALLADLRAAFGGSVVEIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VY5</accession>
    <name>Q63VY5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107731.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1110"/>
    <dbReference type="EnsemblBacteria" id="CAH35103">
        <property type="protein sequence ID" value="CAH35103"/>
        <property type="gene ID" value="BPSL1110"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1110"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1224"/>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACAMPTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266378" evidence="1">
        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="49"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="173" mass="18281" checksum="AA2704F8A73495C4" modified="2004-10-25" version="1">MRLRIARSLRAPLGALTVAALLAACTMPTHPDSGAPAPDPFNPATIQLIDDTSWELVGWRNADGSARDIPHGDNGEPIKLALSTQTGVRRAAGFSGCNRYMGTYDVKNGVLAFGPLAGTRMACVSPARAALERDYLAALGHISKAGVQMRAPQQLVIITDADATLTFARRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W42</accession>
    <name>Q63W42_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107674.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35043">
        <property type="protein sequence ID" value="CAH35043"/>
        <property type="gene ID" value="BPSL1047"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1047"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="85" mass="8805" checksum="07C5943F68219F4D" modified="2004-10-25" version="1">MKAYAGRIAAVEVDGSGEMRACAVCWPVRFGDPWEAVGGRACDRSCIGERAEPGRCRGEPHAGRARVGASVPNPVRAAPAGPSRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W86</accession>
    <name>DCD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dCTP deaminase</fullName>
            <ecNumber evidence="1">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dcd</name>
        <name type="ordered locus">BPSL1002</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dCTP deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192666.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107630.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63W86"/>
    <dbReference type="SMR" id="Q63W86"/>
    <dbReference type="STRING" id="272560.BPSL1002"/>
    <dbReference type="EnsemblBacteria" id="CAH34998">
        <property type="protein sequence ID" value="CAH34998"/>
        <property type="gene ID" value="BPSL1002"/>
    </dbReference>
    <dbReference type="GeneID" id="56596187"/>
    <dbReference type="KEGG" id="bps:BPSL1002"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.567"/>
    <dbReference type="eggNOG" id="COG0717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009693" description="dCTP deaminase">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <sequence length="189" mass="21312" checksum="AC48B8320870E0A2" modified="2004-10-25" version="1">MSIKSDKWIRRMAEEHKMIEPFVPDQVRAAEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W89</accession>
    <name>Q63W89_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative OmpA family transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192130.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107627.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63W89"/>
    <dbReference type="STRING" id="272560.BPSL0999"/>
    <dbReference type="EnsemblBacteria" id="CAH34995">
        <property type="protein sequence ID" value="CAH34995"/>
        <property type="gene ID" value="BPSL0999"/>
    </dbReference>
    <dbReference type="GeneID" id="56596191"/>
    <dbReference type="KEGG" id="bps:BPSL0999"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.571"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGNYMDK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027367">
        <property type="entry name" value="Gly-zipper_YMGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13441">
        <property type="entry name" value="Gly-zipper_YMGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267226" evidence="3">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="95"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="21432" checksum="2493A87C70C2F37D" modified="2004-10-25" version="1">MNTKIATRLSVFALAGALLAGCATQQGTNTAVGTGTGAALGAGIGALAGGGKGAAIGAGVGALVGGVTGYNWQAIKNKLAPSAQQTGTQVTEQPDGSLKLNVPSSVTFATDQYAITPAFTPLLNDLATTLNQNPQITASVVGYTDSTGSAAHNQTLSQNRAQSVVNALAQRGVAANRLSAQGMGASNPIADNATEAGRAQNRRVEIYLRAPQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WC2</accession>
    <name>Q63WC2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA polymerase III chi subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522571.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107594.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0966"/>
    <dbReference type="EnsemblBacteria" id="CAH34962">
        <property type="protein sequence ID" value="CAH34962"/>
        <property type="gene ID" value="BPSL0966"/>
    </dbReference>
    <dbReference type="GeneID" id="56526867"/>
    <dbReference type="KEGG" id="bps:BPSL0966"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.611"/>
    <dbReference type="eggNOG" id="COG2927">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQFEPSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007459">
        <property type="entry name" value="DNA_pol3_chi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036768">
        <property type="entry name" value="PolIII_chi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38767">
        <property type="entry name" value="PTHR38767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04364">
        <property type="entry name" value="DNA_pol3_chi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102400">
        <property type="entry name" value="SSF102400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="138" mass="15394" checksum="B9428D7DD80A90AC" modified="2004-10-25" version="1">MTRIDFHTNVGDSLAYACRLLRKAYQAGQPVVVCAEPARLRALDERLWTFSPLDFIPHCAIDNAHAASTPIVLTADLERAPHHGILLNLGAQVPAQFARFERLLEVVGNAPDELAAGRDRYRFYRDRGYALNNHKQGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WN0</accession>
    <name>QUEG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="1">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queG</name>
        <name type="ordered locus">BPSL0861</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550792.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107486.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WN0"/>
    <dbReference type="SMR" id="Q63WN0"/>
    <dbReference type="STRING" id="272560.BPSL0861"/>
    <dbReference type="EnsemblBacteria" id="CAH34853">
        <property type="protein sequence ID" value="CAH34853"/>
        <property type="gene ID" value="BPSL0861"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0861"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.736"/>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICDTDLS"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00916">
        <property type="entry name" value="QueG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000416066" description="Epoxyqueuosine reductase">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="409" mass="44283" checksum="A7904FE5062C9759" modified="2004-10-25" version="1">MDRNPELAIADARPSQDGRAAPSRLDDAQLAELASRIKAWGRELGFGAIGISDTDLSEAEAGLAAWLEAGCHGEMDYMAKHGMKRARPAELVAGTRRVISARLAYLPAGTLDGAPDAQGARRDWRAREAARIADPQAAVVSVYARGRDYHKVLRNRLQTLAERIEAEIGAFGHRVFTDSAPVLEVELAQKAGVGWRGKHTLLLQRDAGSFFFLGEIYVDVPLPADAQTSPDAAPETPGAHCGSCTRCLGACPTGAIVAPYRVDARRCISYLTIELHGSIPEPLRPLIGNRVYGCDDCQLVCPWNKFAQAAPVADFDVRHGLDRASLVELFEWTAEQFDERMQGSAIRRIGYERWLRNLAVGLGNALRAAPGGIGPDARAAIVAALRARLDDPCVSALVREHVEWALRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WQ5</accession>
    <name>Q63WQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541054.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107461.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0837"/>
    <dbReference type="EnsemblBacteria" id="CAH34828">
        <property type="protein sequence ID" value="CAH34828"/>
        <property type="gene ID" value="BPSL0837"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0837"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.764"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIDRRWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="403" mass="40828" checksum="9C1FE4E4B807F707" modified="2004-10-25" version="1">MSDCTTRPAGFARPSREAARLPLAGLLALATAGFITIVTEALPAGLLPLMGRDLRVSDALVGQLVTVYAAGSIVAAIPLVAATRGMRRRPLLLAALAGFVVANTATAASPYYAPVLVARCVAGVSAGLLWALLAGYASRMVDARQRGRAIAIAMLGAPVAMSVGIPLGTALGAALGWRATFAGVTALTLALIAWVRASLPDAPGRPSGERLPVARVLRMPGVLPVLAVMFAYVLAHNILYTYIAPFLASAGMGARIDATLFAFGAASFAGIGLTGVWIGNGLRRLALASIALFALASVLLGVASGSPAVVYASVAVWGLTFGGAATVFQTASANAAGEAADVAQSMIVTVWNLAIAAGGVAGGVLLERFGAGAMPWALVALLVPAWFGAWRARRHGFPAARAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XA0</accession>
    <name>UBIE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
            <ecNumber evidence="1">2.1.1.163</ecNumber>
            <ecNumber evidence="1">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Demethylmenaquinone methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiE</name>
        <name type="ordered locus">BPSL0637</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="1"/>
    <dbReference type="EC" id="2.1.1.201" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189973.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107266.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XA0"/>
    <dbReference type="SMR" id="Q63XA0"/>
    <dbReference type="STRING" id="272560.BPSL0637"/>
    <dbReference type="EnsemblBacteria" id="CAH34630">
        <property type="protein sequence ID" value="CAH34630"/>
        <property type="gene ID" value="BPSL0637"/>
    </dbReference>
    <dbReference type="GeneID" id="56527152"/>
    <dbReference type="KEGG" id="bps:BPSL0637"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.986"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043333">
        <property type="term" value="F:2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000193259" description="Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <sequence length="243" mass="26955" checksum="ACE84431CF68A06D" modified="2004-10-25" version="1">MSKTHFGFETVEENEKAKKVAGVFHSVASNYDLMNDLMSAGLHRAWKAFTIAQANVRPGGKVLDIAAGTGDLTKAFAKAAGPTGEVWHTDINESMLRVGRDRLLDKGVVTPSLLCDAEKLPFPDNYFDVVTVAFGLRNMTHKDSALAEMRRVAKPGGRVMVLEFSKVWEPLKKAYDVYSFKVLPWLGDKFAKDADSYRYLAESIRMHPDQETLKTMMEQAGLDAVKYYNLSGGVVALHVGTKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XL8</accession>
    <name>KPRS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="1">RPPK</shortName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="1">P-Rib-PP synthase</shortName>
            <shortName evidence="1">PRPP synthase</shortName>
            <shortName evidence="1">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prs</name>
        <name evidence="4" type="ordered locus">BPSL0521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E53851" last="E53851">
            <title>Combining functional and structural genomics to sample the essential Burkholderia structome.</title>
            <authorList>
                <person name="Baugh L."/>
                <person name="Gallagher L.A."/>
                <person name="Patrapuvich R."/>
                <person name="Clifton M.C."/>
                <person name="Gardberg A.S."/>
                <person name="Edwards T.E."/>
                <person name="Armour B."/>
                <person name="Begley D.W."/>
                <person name="Dieterich S.H."/>
                <person name="Dranow D.M."/>
                <person name="Abendroth J."/>
                <person name="Fairman J.W."/>
                <person name="Fox D."/>
                <person name="Staker B.L."/>
                <person name="Phan I."/>
                <person name="Gillespie A."/>
                <person name="Choi R."/>
                <person name="Nakazawa-Hewitt S."/>
                <person name="Nguyen M.T."/>
                <person name="Napuli A."/>
                <person name="Barrett L."/>
                <person name="Buchko G.W."/>
                <person name="Stacy R."/>
                <person name="Myler P.J."/>
                <person name="Stewart L.J."/>
                <person name="Manoil C."/>
                <person name="Van Voorhis W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23382856"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0053851"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH AMP AND SUBSTRATE ANALOGS</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195243.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107147.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3DAH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C=1-318"/>
    </dbReference>
    <dbReference type="PDBsum" id="3DAH"/>
    <dbReference type="AlphaFoldDB" id="Q63XL8"/>
    <dbReference type="SMR" id="Q63XL8"/>
    <dbReference type="STRING" id="272560.BPSL0521"/>
    <dbReference type="EnsemblBacteria" id="CAH34511">
        <property type="protein sequence ID" value="CAH34511"/>
        <property type="gene ID" value="BPSL0521"/>
    </dbReference>
    <dbReference type="GeneID" id="56593812"/>
    <dbReference type="KEGG" id="bps:BPSL0521"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1126"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q63XL8"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000441886" description="Ribose-phosphate pyrophosphokinase">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2 7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 3 7">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="7"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="33"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
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            <begin position="43"/>
            <end position="47"/>
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    </feature>
    <feature type="strand" evidence="8">
        <location>
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            <end position="59"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="146"/>
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        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
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    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="167"/>
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        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="177"/>
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    </feature>
    <feature type="strand" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
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    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
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    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="259"/>
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    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="269"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="281"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23382856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="23382856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="3DAH"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="3DAH"/>
        </source>
    </evidence>
    <sequence length="318" mass="34211" checksum="610A0423F8988DA7" modified="2004-10-25" version="1">MSSHDGLMVFTGNANPALAQEVVKILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPTNDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNYPDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLKERGAKQVFAYATHPVLSGGAADRIAASALDELVVTDTIPLSAESLACPKIRALSSAGLLAETFSRIRRGDSVMSLFAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XN8</accession>
    <name>Q63XN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ordered locus">BPSL0501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537839.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107127.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0501"/>
    <dbReference type="EnsemblBacteria" id="CAH34491">
        <property type="protein sequence ID" value="CAH34491"/>
        <property type="gene ID" value="BPSL0501"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0501"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1150"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLWGVAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="378" mass="41141" checksum="9F971DDFF9CBC4AA" modified="2004-10-25" version="1">MDYATLKVIWWLLVGILLIGFALTDGFDMGVAALLPFLGKTDDERRIIVNTVGATWEGNQVWLITAGGAMFAAWPLVYAASFSGFYFAMLLVLFALFFRPVGFDYRSKRDDPRWRTSWDWALFAGGFVPALVFGVAFGNLLQGVPFAFDTDMRVTYHGSFWALLNPFALLCGLVSLTMLVAHGAAFVKMKTDGAIARRASIALRVSSLVAVVLFVLAGALIASFIGGFQITQAAPLDTVANPLLKQASTAPGLWLVNYGLYPWMIAAPAVGIAGGVLAMLLAGSKREKTAFICTGLMITGVILTAGFSMFPFIMPSSLDPKSSLTVWDSTSSQLTLEVMLVAVIVFLPIILLYTGWVYRVLRGKVTPRVLDENRHSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP5</accession>
    <name>Q63XP5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107120.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0495"/>
    <dbReference type="EnsemblBacteria" id="CAH34484">
        <property type="protein sequence ID" value="CAH34484"/>
        <property type="gene ID" value="BPSL0495"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0495"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.553"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMTMKRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="254" mass="27788" checksum="53CB85BC338A398A" modified="2004-10-25" version="1">MPFRFRTRRPMDIGWSTLAPDARSDTPLYLQLARNLAGAIHGGAWRAGEALPSERGLSAAAGVSRITARRALALLVEQGLIRRVRGAGSFITPRVADPLSRLVGFTAKMRQRGFAPDSVWLARSLRAASRDELARFGLSPGATVARLERLRRADGVVMAYERSTLPANCVPEPQALEGSLYGYLQSRGLDVVRASQRFRAVNASADVAQWLGLAPGAALLVITRIGYGADRRAIEATETYCRDDYYDFVAELKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR8</accession>
    <name>DNAE2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaE2</name>
        <name type="ordered locus">BPSL0472</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543942.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107097.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XR8"/>
    <dbReference type="SMR" id="Q63XR8"/>
    <dbReference type="STRING" id="272560.BPSL0472"/>
    <dbReference type="EnsemblBacteria" id="CAH34461">
        <property type="protein sequence ID" value="CAH34461"/>
        <property type="gene ID" value="BPSL0472"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0472"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1183"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NSWPMGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01902">
        <property type="entry name" value="DNApol_error_prone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000103374" description="Error-prone DNA polymerase">
        <location>
            <begin position="1"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01902"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118134" checksum="C627677138FFFF65" modified="2004-10-25" version="1">MDAASGILPDYAELFCRSNFSFLHGASSAEELVERAAKQGYRGIAITDECSLAGAPRMHVAAKAVGLPLVVGAYFGVTPDDAAPGHDPGPGAFGLVLLAQNREGYGNLSELISWRRMNAPKGTYRLTPRMLAAPPRALAHLRGVPDCFAILVPTYPARADVLDAQLAWFDALFGERARLGLVQLQRALDGAHREQVRAAGERRGMHIVALGDVTMHIRSCKPLQDTMTAIRLGMPIAECGHALAPNGEQHLRTRQRIAQLFPADALAQTCRMLDACHFSLDDLRYEYPHEIVPAGHTPTSYLAQETWAGARRRYPDGVPDTVRQRIEFELALIADLKYEPYFLTVYDIVKYARSKDILCQGRGSAANSVVCYCLGVTEVNPQQSTLLFERFLSRERGEPPDIDVDFEHQRREEVIQYLYEKYGHDRAALAAAVSTYRPRGALRETGKALGVDPMLVERVAKEHRWFDGSRDLLARFASVGLDPEVPLIRTWAEIAARLLNFPRHLSQHSGGFVVSRGKLTRLVPVENAAMEGRRVIQWDKDDLEALGLMKVDVLALGMLSALHRAFDMITAWRGPPLPDGRPFRLEHIPQDDEATYDMICRADTVGVFQIESRAQMSMLPRLRPRGYYDLVVQVSIVRPGPIQGGAVHPYLERRRIAAGEAHGEITYPSEALERVLERTLGIPIFQEQVMQIAIVAAGFTPGEADALRRAMAAWKRKGDLGKYHERIVAGMLERGYSREFAEQIFEQIKGFGEYGFPESHAASFAKLAYASSWLKRHEPAIFLAALLNSQPMGFYPPAQLVQDAKRHGVTVLPIDATKSGWEASLEAQPGAAPPDGRPAVRLGLSLVRGLGEEAARRIGAARAAGPFASVDELARRACLERRDLEALAAANAFATLAGNRRDALWQAVAAAPERGLLAAAPIDEAVRPALGAPTEADDVFADYRTIGLTLNRHPVALLRPALDARRLSSAAALRDRRNGRLARACGLVTARQMPGTAKGVLFVTLEDETGCVNVIVRPELLERQRRETLDSQLLAVSGVWQCESDVRHLVAQYLEDLTPLIAGLRTESREFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y13</accession>
    <name>Q63Y13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535631.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107002.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0376"/>
    <dbReference type="EnsemblBacteria" id="CAH34364">
        <property type="protein sequence ID" value="CAH34364"/>
        <property type="gene ID" value="BPSL0376"/>
    </dbReference>
    <dbReference type="GeneID" id="56527380"/>
    <dbReference type="KEGG" id="bps:BPSL0376"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1292"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQMLWFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266662" evidence="1">
        <location>
            <begin position="21"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="65"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="528" mass="57192" checksum="F02C650161C9AB25" modified="2004-10-25" version="1">MRFTHIAAAALVAAASVAAAKPLTVCTESSPDGFDVVQYNSLVTTNASADVVFNTLVSYDEATKKVVPALADKWDVSADGLAYTFHLRPNVAFQTTDSFKPTRALDADDVVFTFGRMLDDANPWHKVAGASGFPHAQSMGLAKLVKAVTKIDESTVKFELNEPNATFVPILTMGFASIYSAEYADQLLKAGKQADLNAKPVGTGPFVLKSYTKDAVIRYEANPTYWGPKPKVERLIYAITPDPSVRAQKVKAGECQIALSPKPQDVAAAKADRALRVVETPAFMTAFVALNTQKKPLDNDKVREALNLAFDRATYLKVVFDNTATPATNPYPPNTWSYAKSIAPYPHDPAKAKQLLAQAGFPNGFSTTIWVRPTGSVLNPNPKAGAELLQADLAKIGVKADVRVIEWGELIKQAKLGQHDLLFMGFAGDNGDPDNILTPQFSCNSVKSGLNFARYCDPKLDKLIADAKETADQAKRAKLYEAAQKIIHDEALWIPLGYPTAAAITRPNVAGYRVSPFGRQHFDAVSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y65</accession>
    <name>Q63Y65_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189860.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106950.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0323"/>
    <dbReference type="EnsemblBacteria" id="CAH34312">
        <property type="protein sequence ID" value="CAH34312"/>
        <property type="gene ID" value="BPSL0323"/>
    </dbReference>
    <dbReference type="GeneID" id="56594641"/>
    <dbReference type="KEGG" id="bps:BPSL0323"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1363"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MASNEQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="273"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="519" mass="53642" checksum="3F3E187D9A585223" modified="2004-10-25" version="1">MNTTRLTVKTRLRILVAIVVLVLAAAGGIGLAGVARVGDALTHVFEDRAKTLQRISSVDELVTQARYAVGDAVLDPSAAKTEAVAAAAARDVAAIDRLLADFRATPRAGAEREQAERLAADWATLRDKGIRPAVDLLKANNLSEAQWVVTQTLDPVAQRVKGEAAQLRQNQLEAAQRAYDRARGVARLVQWAVAGCVLAGVAAVAILCAAMARALARQLGGEPDYAASVANEIASGNLALDLHAADAAAGSVLHAMHAMRARLAATIGTLQRAADAIAHATSDIAHGNHDLSRRTDEHAAGLQQTASSMEQLAATVRTNADHARQASALALAASTQAEQGDAAARDAIARMEALSVRSQQIRSISSTIEGIAFQTNLLALNAAVEAARAGQAGRGFAVVAQEVRGLAHSSAQAAKEISALIADVTGEVELGADTVKAAGSTIVGMLASVRQVATLVDEISHASDEQRSGIDQVSRAVAQMDEMTQHNALLVQKAAGAAGALADEAAALREAAAIFRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YF6</accession>
    <name>Q63YF6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fliE</name>
        <name evidence="4" type="ordered locus">BPSL0231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534368.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106859.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0231"/>
    <dbReference type="EnsemblBacteria" id="CAH34219">
        <property type="protein sequence ID" value="CAH34219"/>
        <property type="gene ID" value="BPSL0231"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0231"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1481"/>
    <dbReference type="eggNOG" id="COG1677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMQVKAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="11479" checksum="61928D555FBEEE3B" modified="2004-10-25" version="1">MVAPVNGIASALQQMQAMAAQAAGGTSPATSLAGSGAASAGSFASAMKASLDKISGDQQKALGEAHAFEIGAQNVSLNDVMVDMQKANIGFQFGLQVRNKLVSAYNEIMQMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK3</accession>
    <name>Q63YK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative rod shape-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523092.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106812.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0184"/>
    <dbReference type="EnsemblBacteria" id="CAH34171">
        <property type="protein sequence ID" value="CAH34171"/>
        <property type="gene ID" value="BPSL0184"/>
    </dbReference>
    <dbReference type="GeneID" id="56527576"/>
    <dbReference type="KEGG" id="bps:BPSL0184"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1535"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWAMALP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026034">
        <property type="entry name" value="MreD_proteobac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37484">
        <property type="entry name" value="PTHR37484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018472">
        <property type="entry name" value="MreD_proteobac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="170" mass="18907" checksum="0ED36E807979A51D" modified="2004-10-25" version="1">MSRPQYILQPVNPYFIVFSLAAAFLLNLMPWGRVPGVPDCVALVLLFWNIHQPRKVGMGVAFALGILMDVHDAGLLGEHALAYTLLSYGAITIHRRVLWLPLGVQIFYVAPLLVIAQLVPFVIRLLMGAAFPGWSYLVDGFVEAALWPVASHLLLMPQRRPVDPDDTRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YP7</accession>
    <name>Q63YP7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106768.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0140"/>
    <dbReference type="EnsemblBacteria" id="CAH34127">
        <property type="protein sequence ID" value="CAH34127"/>
        <property type="gene ID" value="BPSL0140"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0140"/>
    <dbReference type="eggNOG" id="ENOG50317F6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CRSASNM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="64" mass="7174" checksum="19E0ACE7F67134E6" modified="2004-10-25" version="1">MLSNKPVYMRLMPDERRTLEELSASQNRSTSSVARLIYLEGVERYQAKVTDASAQAHANPVVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YQ3</accession>
    <name>Q63YQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage-encoded membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106762.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0134"/>
    <dbReference type="EnsemblBacteria" id="CAH34121">
        <property type="protein sequence ID" value="CAH34121"/>
        <property type="gene ID" value="BPSL0134"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0134"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.149"/>
    <dbReference type="eggNOG" id="ENOG50314ZX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHCLTAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="69" mass="7519" checksum="DB4CE5B78FAD1881" modified="2004-10-25" version="1">MRNHTMKPYVFGVGVLLMLSFSLTGIHCLTADVLRLFDVRHARTIAFAVGVAALVALVAALAWSVPPRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR4</accession>
    <name>HTPX_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protease HtpX homolog</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpX</name>
        <name type="ordered locus">BPSL0124</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189409.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106751.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YR4"/>
    <dbReference type="STRING" id="272560.BPSL0124"/>
    <dbReference type="EnsemblBacteria" id="CAH34110">
        <property type="protein sequence ID" value="CAH34110"/>
        <property type="gene ID" value="BPSL0124"/>
    </dbReference>
    <dbReference type="GeneID" id="56596707"/>
    <dbReference type="KEGG" id="bps:BPSL0124"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1599"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REYMADS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000077458" description="Protease HtpX homolog">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <sequence length="285" mass="30929" checksum="DD286008BE417DB2" modified="2004-10-25" version="1">MFNWVKTAMLMAAITALFIVIGGMIGGSRGMTIALLIALGMNFFSYWFSDKMVLRMYNAQEVDEATAPQFYRMVRELATRANLPMPRVYLIDENQPNAFATGRNPEHAAVAATTGILRVLSEREMRGVMAHELAHVKHRDILISTISATMAGAISALANFAMFFGGRDENGRPANPIAGIAVALLAPIAGALIQMAISRAREFEADRGGAQISGDPQALASALDKIHRYASGIPFQTAEEHPATAQMMIMNPLSGGGLQNLFSTHPATEERIARLMDMARTGRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS2</accession>
    <name>Q63YS2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525849.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106743.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0116"/>
    <dbReference type="EnsemblBacteria" id="CAH34102">
        <property type="protein sequence ID" value="CAH34102"/>
        <property type="gene ID" value="BPSL0116"/>
    </dbReference>
    <dbReference type="GeneID" id="56527597"/>
    <dbReference type="KEGG" id="bps:BPSL0116"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1608"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KHGAWQQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="111"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="37400" checksum="2120A03F5914B5D4" modified="2004-10-25" version="1">MKIAILDDYQDAVRKLNCFEMLADHEVKIFNNTVRGLGQLASRLAEVEALVLIRERTHITSQLLGKLPHLRMISQTGRVSTHIDLEACTERGIAVLEGTGSPTAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIWGYGKVGRLVAGYGKAFGMNVLIWGREHSLEAARADGFEAAESREAFFEQADVLSLHLRLHDDTRGVVKLDDLLRMKPTSLLVNTSRAELLEENALVSALARNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFRNILAFDAGDLSSVANPDALTQGRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YY2</accession>
    <name>Q63YY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202848.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106683.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0058"/>
    <dbReference type="EnsemblBacteria" id="CAH34041">
        <property type="protein sequence ID" value="CAH34041"/>
        <property type="gene ID" value="BPSL0058"/>
    </dbReference>
    <dbReference type="GeneID" id="56594148"/>
    <dbReference type="KEGG" id="bps:BPSL0058"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1683"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHSPMCE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="328" mass="36942" checksum="9C2273D39130CE1C" modified="2004-10-25" version="1">MNDRIRIRDLFTRDEIRALTARSNWRGAWAVGSTWAVIALAFAGLAYARAHFPAWGFALALAAGMTIIAGRQLCLGILQHDAAHGTLFRTRWANDVLVDWLCARPIWNALHKYRPYHLMHHATTSSRADPDLSLVAGLPTTRASLARKCLRDLSGVTGVKFLIGRALMDAGVLQWSLTNDIRRLPQTGRRWWDYPRAFLRAAAGMLITNAILLGALWASGHPWLYGVWVLAYVTPFPLFIRIRSMAEHACLETSDDPLRNTRTTHAGWLARATVAPIRVNYHVEHHLMASVPYFRLPKMHRMLRARGCVARPPSYWQVLRTVSAKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H7C774</accession>
    <name>H7C774_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528701.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111399.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1387"/>
    <dbReference type="EnsemblBacteria" id="CAH38862">
        <property type="protein sequence ID" value="CAH38862"/>
        <property type="gene ID" value="BPSS1387"/>
    </dbReference>
    <dbReference type="GeneID" id="56530189"/>
    <dbReference type="KEGG" id="bps:BPSS1387"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4708"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LLMHFAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="17852" checksum="DB043A978A4A36AA" modified="2012-04-18" version="1">MRRVLLDRSDEVMRFVADRTGESRYDDYATIGLERDGRIVAGVVYQGHGGPNVLMHFALDGSRHLATPAFVCAVFTYPFKVLRCNRVTGLVRTDNHEAQRLDEHLGFVREGVMRAGASDGTDFILYGMLKAECRFLSGKYVEALRVELAGSIDGVLASVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I18</accession>
    <name>Q63I18_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LPS biosynthesis related transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529463.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112254.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2251"/>
    <dbReference type="EnsemblBacteria" id="CAH39737">
        <property type="protein sequence ID" value="CAH39737"/>
        <property type="gene ID" value="BPSS2251"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2251"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5854"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHGSWTT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="316" mass="35427" checksum="DEA91D7B1EC087A0" modified="2004-10-25" version="1">MSPKRLRVLTWHVHGNYLYYLSQAPHDFYVITKPNHPPGYAGCVGHLPWGENVREVPYECVPDAEFDCVLYQHHRHYAHDREHLLSAAQRALPAIFVEHDPPREHPTDTCHPVQNPNVLLVHVTPFNALMWDSGVTPTRVIEHGVLLPRDVVYRGTLPKGVTVVNHLVRRGRRLGSDLFETVRHLVPVDLVGMGSAQAGGIGEVPNPELPAFLSHYRFFFNPIRYTSLGLAVVEAMTIGLPIVALATTEMAQLVRTGHNGVADTRIDVLVDAMRTLIRDPRLAAEWGAAARRDALERFGIERFARDWDDALRAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I66</accession>
    <name>Q63I66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529417.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112206.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2204"/>
    <dbReference type="EnsemblBacteria" id="CAH39689">
        <property type="protein sequence ID" value="CAH39689"/>
        <property type="gene ID" value="BPSS2204"/>
    </dbReference>
    <dbReference type="GeneID" id="56531707"/>
    <dbReference type="KEGG" id="bps:BPSS2204"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5789"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WMTRENF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="255" mass="28101" checksum="02ADF1F19D212477" modified="2004-10-25" version="1">MNSLDSNHLLNPARAPARPLGDAAERRSLKASPRVQRVLDELVTRIVDGEYTSGLLPPQDVLARELGVPRSVMREVTRMLTARRMLHARTKAGTRLTPRSEWRLFDDHVMQWRMRIASDTDFLLDVAAMCDLIEPEAAAQVALHSDDTQRRAVRAAHAALRDALEPDALRRALELLHASIVEASRNQFIRQMAEVARAGVMAIDLDAATLQERNEAIRDAAAKLVAAIDGRDADGARTAMIALRAAVNETSLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I67</accession>
    <name>Q63I67_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid transport, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537978.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112205.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39688">
        <property type="protein sequence ID" value="CAH39688"/>
        <property type="gene ID" value="BPSS2203"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2203"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5788"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FSMLKIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="26"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="476" mass="51168" checksum="A19EAFBE881122BD" modified="2004-10-25" version="1">MSSERQFQAIAQREGGLRRTLSARQMTMIAIGGAIGTGLFLGSGFAIGFAGPSVLISYAIGALISLLLMGCLAEMTVAHPTSGSFGAHAEHYLGPWAGFLVRYAYWACIVLAVGTEVTAVALYMKYWLPAVPGWVWIAGFSAVLVFVNALSVDVFGSVEYGFSVVKIAAIVAFIAIGGYVVFVDPSLVADPNAGAPGLRHYFGHGGFFPKGLWGTWVAVIVSIFSYLSIEMIAVAAGEAQDPERAVTRAFRSTVIRLVLFYLVTLALMLAIVPWTAAGRDESPFVKVMIAIHLPGAAGVINFVVLIAALSAMNSQLYITTRMMFSLACAGHAPRGLGRLTRRGVPLNALLLSTAGIAIATLVSVAYPDASFTIMMAISMFGAMFTWTMIFVTHYFFRRKRAAQGLPPPRFRMPGFPLATLAGAALMLAIMATTYFTPEFHMTLVFGAPFLAALSVLYFARYRRRPHALARAESQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I87</accession>
    <name>Q63I87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552234.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112185.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2183"/>
    <dbReference type="EnsemblBacteria" id="CAH39668">
        <property type="protein sequence ID" value="CAH39668"/>
        <property type="gene ID" value="BPSS2183"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2183"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5764"/>
    <dbReference type="eggNOG" id="ENOG502Z9HB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYARYAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="474" mass="49900" checksum="7392D7E541FFB0FC" modified="2004-10-25" version="1">MKAHPHGHAAMHRDVECPALPTAGPRRRPHWLSAKRVRTYAIAALVCYAAFGGIYLARWLSGGLGSPLPPALDFVPAWSAAHLAVHGHALDAWRFAALHPVELQAAPSMRGMRGVLLWLYPPQTLLLVAPLGWLPYPVAALAWVVGTGVLFVATVRAIVPRRLSTLCALAFPGTFLVALVGQNSLLTAALAGFGLVALRRRPALAGCCFGLLVIKPQLAPLFPLALLCASQWRALSAWAATVALVAALSTFAFGFGAWAAFAHGAASALQTIGAGQATLARIPTFFAMATFAGLPLFAARLLQAAAIAFAAGAVIYAWRGACAHALRSAALVCASLLVSPYLYDYDLAWYAIVIAWAVRHAHAQGWRPLEREGLAALALMPLAGLVAVEPLGFQFLPLVTAGALAAIVVRIARERHGAPCLADDEAAADAIDSIRFMTARGAPDAAPRRARAAAWPLAGRRRRGVQGEASCGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63II2</accession>
    <name>Q63II2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941143.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112090.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39570">
        <property type="protein sequence ID" value="CAH39570"/>
        <property type="gene ID" value="BPSS2090"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2090"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6478"/>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008008">
        <property type="entry name" value="DUF746"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05344">
        <property type="entry name" value="DUF746"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF746" evidence="1">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF746" evidence="1">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="142" mass="16251" checksum="811FBC060502DAB1" modified="2004-10-25" version="1">MTAWRAWLLELDPSGKWERRVRLSHRPPHCPNCGSHQTRFDECSNGAFPRFKCANCGTKFTRRRGTPFVNAKMSSPERMRLVIRRLSLPLLVMQVADLVGTSHGMVRKWHSMFTDFADRLEPSGSLSARIRLRSNSANAPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IT1</accession>
    <name>Q63IT1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529215.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111991.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1985"/>
    <dbReference type="EnsemblBacteria" id="CAH39463">
        <property type="protein sequence ID" value="CAH39463"/>
        <property type="gene ID" value="BPSS1985"/>
    </dbReference>
    <dbReference type="GeneID" id="56531900"/>
    <dbReference type="KEGG" id="bps:BPSS1985"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5490"/>
    <dbReference type="eggNOG" id="ENOG5033NZN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHETFAP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="28048" checksum="E1D629433E96D665" modified="2004-10-25" version="1">MSTTDVSQDMRVAPDSVRVWRGFRLPSLGLDQFLGKLGTVFVPATVKMQIDAGLRAYAPTVPAGLPGKPATVPDETAILFWASPETYWNGFTRLAVRTYTLTHGGVYLTQDNQSRADFPVRFDGALGVDQPVYLYDAPADWMHGAIRHLVAARPPAVDPASFRSNVAKALGDIQRSVPLAGALACAGNDYVVYWELGPVAAGAAQAPSGVPRLQTALTDWSETFASAPTFLPIGLWDEWAGMDVRSGSSFNMQFAREASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J85</accession>
    <name>Q63J85_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">udg2</name>
        <name evidence="12" type="ordered locus">BPSS1833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
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        <property type="protein sequence ID" value="CAH39309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
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    <dbReference type="EnsemblBacteria" id="CAH39309">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="UDP-Glc/GDP-Man"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="324"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        <location>
            <position position="86"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="121"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="267"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="273"/>
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        <ligand>
            <name>NAD(+)</name>
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            <position position="331"/>
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            <position position="338"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="473" mass="51046" checksum="C1761657157F9105" modified="2004-10-25" version="1">MNLTIIGSGYVGLVTGACLADIGHDVFCLDVDSKKIDVLNNGGVPIHEPGLGEIIARNRAAGRLQFSTDVEAAVAHGDVQFIAVGTPPDEDGSADLQYVLAAARNIGRHMNGFKVIVDKSTVPVGTAERVRAAVADELKARGEDSMFSVVSNPEFLKEGAAVEDFTRPDRIVIGCDDDVPGERARELMKKLYAPFNRNHERTLYMDVRSAEFTKYAANAMLATRISFMNELANLAERFGADIEAVRRGIGSDPRIGYHFLYAGCGYGGSCFPKDVEALIRTAAEHGQALRVLQAVSAVNDEQKHVLARKVVARFGGDLTGRRFGVWGLAFKPNTDDMREAPSRALIAALLSRGAHVVAYDPVAQDEARRVLAIDLGEYPDALGRLAFADDEAQVAQDADALVIVTEWKAFKSPDFAALGKRWKTPVIFDGRNLYEPIAMRELGIEYYPIGRPGAAPRTAAGESDAARAARAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JA9</accession>
    <name>Q63JA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111813.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1809"/>
    <dbReference type="ESTHER" id="burps-q63ja9">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39285">
        <property type="protein sequence ID" value="CAH39285"/>
        <property type="gene ID" value="BPSS1809"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1809"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5252"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALCRLIC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="30674" checksum="AFBD2184DB25FB15" modified="2004-10-25" version="1">MSAREAAAESPWLIVHEARNARVRLFCFHYAGATASIFRTWPGGLPDWIEVVAVQLPGREYRLGEPLIEHAEPIVEALADIVPPLLDLPYAFFGHSMGALIAFDLAHLLRARGFAQPLLFVASGRSAPRFRWRDAGIQTLADEAFIAAVRDYNGTPEALIADPALRELWLPRLRADLTISATYRYVGPPPLDCPMLVLHGSNDGLVSDAGLSGWLAETIGAVRYVGFSGGHFFMHGEEAGVLAEVRRELERVLARAAQDEPNGMREPAARMSHLTEESGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JB0</accession>
    <name>ACDH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="1">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mhpF</name>
        <name type="ordered locus">BPSS1808</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552044.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111812.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JB0"/>
    <dbReference type="SMR" id="Q63JB0"/>
    <dbReference type="STRING" id="272560.BPSS1808"/>
    <dbReference type="EnsemblBacteria" id="CAH39284">
        <property type="protein sequence ID" value="CAH39284"/>
        <property type="gene ID" value="BPSS1808"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1808"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5251"/>
    <dbReference type="eggNOG" id="COG4569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSAYVHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03215">
        <property type="entry name" value="ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000387634" description="Acetaldehyde dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="162"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <sequence length="297" mass="32346" checksum="03A1F8782B7CA1CB" modified="2004-10-25" version="1">MKSKSSRTRVAILGSGSIGLDLMFKVKASEQFDLKFVVGRNANSDGLRLARSCNVETSSDGLDFLKAHEDAYDLVFDATSAAAHKVNNRFFSDAGKFVIDLTPAKVGRLCVPCINLDDMGAEQNVNLITCGGQASLPLAYALKQAVDEIDYLEVVSAIASRSAGIATRENIDEYMTTTEYALAKFSDAKKTKAILNINPAEPGVRMQTTLYAYARYRDFDRVRASVADMVEKVREYVPGYRLVVEPLESQGRITIGLTVRGRGDYLPEYAGNLDIINCAALAVASHRHATARLGATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JV5</accession>
    <name>Q63JV5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940868.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111617.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39084">
        <property type="protein sequence ID" value="CAH39084"/>
        <property type="gene ID" value="BPSS1609"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1609"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4993"/>
    <dbReference type="OMA" id="HARMPRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="22183" checksum="F8C03CC52ABB1E24" modified="2004-10-25" version="1">MPRIQSSSPPITPSITANQPTNGANARAAVTRQKRPAGHATLSKLASSGKKVLHARMPRKGKLAQPGANSSGAATSKPAVPKADAPPAHAQVQANAHEGDLIDLSDPPPTTKPAGMQPSLLDAQPNDLHALHTPVLQPTVLHSAAAPAAHGAQPLGQTLAAAGMPSLQDIHHTTDQAIAMQHAIGQANQRLAIAEMLNSFMQKVIDMIKKAASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JX5</accession>
    <name>Q63JX5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205646.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111597.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39064">
        <property type="protein sequence ID" value="CAH39064"/>
        <property type="gene ID" value="BPSS1589"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1589"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4970"/>
    <dbReference type="eggNOG" id="ENOG5032VXM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REQHYAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="29335" checksum="5EE913E1B932BE21" modified="2004-10-25" version="1">MTLKHLPPTFCWTKIGHESGEELPTVVLRKEWERRLGGGRFLWGIGQPLGNSAQIAAHRTGSLIALFSPASSRARQPERKTEDVLLWNAWIDASGQVRQLPLHTFITSRATLPSGRRREHYYALVCASPTELSIGTRLRVYPDHLRSVSTGKVLGAAQSAAVVDCVGRDAEQSGRSYPLALSVELEAPYFVRLTQPSLLKARDLADITKATRDGDFDTFVEQVTRLRSRPAAKQTRGFTRDLFDLSPAESAAPFGNAAPAHANHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K49</accession>
    <name>Q63K49_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551886.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111523.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1517"/>
    <dbReference type="EnsemblBacteria" id="CAH38990">
        <property type="protein sequence ID" value="CAH38990"/>
        <property type="gene ID" value="BPSS1517"/>
    </dbReference>
    <dbReference type="GeneID" id="56597862"/>
    <dbReference type="KEGG" id="bps:BPSS1517"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4868"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010261">
        <property type="entry name" value="Tir_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05932">
        <property type="entry name" value="CesT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="147" mass="16579" checksum="4FE3CF6E35CCBC2F" modified="2004-10-25" version="1">MATQDIYCALVNEWFQHLGLEKTKDTSSKPVTINVDDRFDVHCCLASNEKMLMIAEWPALNLTEVTLAKALKENQPASQAMQPNIALRDDKYWQCWIDIPINGCGLPELMEGFRLVTQYADRLLDGISEDGGASAVNSFRSKHSFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K60</accession>
    <name>Q63K60_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556233.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111512.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1505"/>
    <dbReference type="EnsemblBacteria" id="CAH38978">
        <property type="protein sequence ID" value="CAH38978"/>
        <property type="gene ID" value="BPSS1505"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1505"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4852"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NMEDINM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="354" mass="38058" checksum="5C38A08874BFE187" modified="2004-10-25" version="1">MSDLVHTALAALADTRTLTGIDLSDADLSGRDLSGCTFERVSLRGANLSAAQLDATRWLQCDLTGARLDGATLGESSWHAVALRAASLRATTGDAFAMTETDLAGATLTDALWARATFERGDFSAAQCGRAKLLRCEAADCRFERTDFANAELERFVAMRAELSSARFDATRLTHAFFAEANLRGQRFERCDLTMTHFSRAALAGCDFSGASLMQTMFFDADLERATLAGARGRHVRFAGATLDGANLAHAAFDESDFARARLRTANARGLRARMSLFAHADCAEATLAGGHFVYCDFSHATLSHADCTGADFSHANLHGLADHAARWDGARKTGARATDPALAHAERWTAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K94</accession>
    <name>Q63K94_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184857.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111478.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1471"/>
    <dbReference type="EnsemblBacteria" id="CAH38943">
        <property type="protein sequence ID" value="CAH38943"/>
        <property type="gene ID" value="BPSS1471"/>
    </dbReference>
    <dbReference type="GeneID" id="56597723"/>
    <dbReference type="KEGG" id="bps:BPSS1471"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5714"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFTFDHH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="232" mass="26822" checksum="A181A32B0A31EFE0" modified="2004-10-25" version="1">MPPSDHAKMKQGSKAAAPDAEARRDEARRKYDPEQTKRNILDVATQEFSAMGLSGARVDAIAERTNTTKRMLYYYFDSKEGLYEAVLEKVYGDIRTLERELNVGELEPREGLSRLVEFTFDYHDRHRDFVRLVTIENIHGAKYIEQLKSFKNRNVSIIKTLEELLARGVESGVFRDDVDPFDLHLLISSFCFHRVANRYTFGTAFGRDPSSPRLRARHRAMITDTVLRYVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE9</accession>
    <name>Q63KE9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556209.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111423.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1411"/>
    <dbReference type="EnsemblBacteria" id="CAH38886">
        <property type="protein sequence ID" value="CAH38886"/>
        <property type="gene ID" value="BPSS1411"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1411"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5644"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGDYDTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="40079" checksum="6337633329C8E622" modified="2004-10-25" version="1">MRANRNNGLTAGALPPNSAAPDDAAKAAPPVAQSDRGAGPLAGLTALKADRAQCMSARPSIRSTTKAPAVMSHARADTSRELTPVEARIAQTFVRPEHLRAIAAAARAGSFAVSFRASGQLSLKRLANGAPAKGHDILEKTIKPGSVQEVYGADSERRLAQIERADIDGYVGHWGRDKLLGLYMGPAANERDTPMLFAALRSTPSGHRYYPVDHDDLEGSLALLKRTQGPSGTAGSFWMSLPYTGDYDTHDMINMAGHRTPVPSGSRDEHRIMRSLNVAIEAIDPIRKASSGSHRLIQHGPQHNYVAHMRTNEQGAVIDEAVARASFPLAMCDRGTWSVIETPEALAAFYRQHGVVLKEKWREKRANTFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KL8</accession>
    <name>Q63KL8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184504.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111353.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1343"/>
    <dbReference type="EnsemblBacteria" id="CAH38814">
        <property type="protein sequence ID" value="CAH38814"/>
        <property type="gene ID" value="BPSS1343"/>
    </dbReference>
    <dbReference type="GeneID" id="56597546"/>
    <dbReference type="KEGG" id="bps:BPSS1343"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4644"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NISICNI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="94" mass="9817" checksum="E0DA5022E10EE8FF" modified="2004-10-25" version="1">MTALVQRFGAAIRQLREARAWSQEQLAEHAGLNRSYVGEIERGTAIASIVTVDKLARAFGVPIARLLSPAGDAGPPPHGFGAPPASSAPLSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KN9</accession>
    <name>Q63KN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111332.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1322"/>
    <dbReference type="EnsemblBacteria" id="CAH38793">
        <property type="protein sequence ID" value="CAH38793"/>
        <property type="gene ID" value="BPSS1322"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1322"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4619"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMTPYAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="31720" checksum="1566CE3BD41B8EE4" modified="2004-10-25" version="1">MAKLDHRNQSRYWHSPGISGVDLLLADFTTHDYAPHVHDSLVVAVTEVGGSVFKSRGQTRLAEPNAVLVFNPCEPHSGRMGGSSRWRYRSFYLAEAGLSRVLTLLGMAQPRFFTSNVLDDPQLVEQFLTLHRAMDEQDDLLRQQELLVSSFGTLFSRHGLQAGLGAGPGFGTKAGLPALKPALDLMNDCFDHALTLEQIAAAAGLTSFQLITAFNRVIGLTPHAYLNQLRLRAALRELQAGRSLADAALTSGFYDQSALCNHFKRTFGMTPMQYTRALAPGKRALAPIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KY0</accession>
    <name>Q63KY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative binding-protein-dependent transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197717.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111241.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1233"/>
    <dbReference type="EnsemblBacteria" id="CAH38700">
        <property type="protein sequence ID" value="CAH38700"/>
        <property type="gene ID" value="BPSS1233"/>
    </dbReference>
    <dbReference type="GeneID" id="56597452"/>
    <dbReference type="KEGG" id="bps:BPSS1233"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4482"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMIVVTQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="292" mass="32283" checksum="7CEF08EE9F18F01B" modified="2004-10-25" version="1">MFNHGKTSLPWLFLGPPLALMAVLGLVPTIAAINLALKNRVLRYADSDYVGLRNFVRLASDRRFLNAIEVSALWEAVTVAGAVAVGIVLAVFLFERVHGRWRHAAALILIMPVLLPRVSAAFIWKFMYAPLTGILGWLLGALGMTNVAWLADPRLALAAVALVDVWQWGLFFCVVVLKLLETLPPEPLEAARLDYASTWQVYAYIALPMLKAPIMSLVFIKMVESLRSFDLIYVMTKGGPGIATETLDMYAYAQGIGLSGKVSYASSMAVLMMVATTLVFTFIWKRVDKWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KY1</accession>
    <name>Q63KY1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556162.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111240.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1232"/>
    <dbReference type="EnsemblBacteria" id="CAH38699">
        <property type="protein sequence ID" value="CAH38699"/>
        <property type="gene ID" value="BPSS1232"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1232"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4481"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="STNTYGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267321" evidence="1">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="426" mass="46198" checksum="6D0FE08090BE4910" modified="2004-10-25" version="1">MNTIRLLGAAALVGACAPLAAAAATPVCKVPTLKVLAQKSLGLSVMEKSLPDYEKTSGTRIEINYFGENDRRAKSRLDASTGAGSYQIYYVDEANVAEFASAGWIAPLIKYYPKEYDYDDFLPGRRAVASYKGVAYFAPLIGGGDFLFYRRDLLDAAHLPVPKTLDELVAAVRKLNAPPKLYGWVARGQRGSGMNVWRWAPFMLAQGGAWTDPHGQPAFNSPAAVQATERYRDLFNYAPPGAATYDWSNALEAFRSGKVAFMIESTPFADWMEDPSKSSVAGKVGYARPPAPLPSAAYGHGLAISSVGAKDDCTRQAAGRFIAWATSKEQEQARLRNGVFSDYNRTSTIGSDYFRQHVKPQILAGLNDTNPVTKATIWATPQWPDIGDNLGVALEEVFTGTQTDVRGALDDAAQYAKDAMAHGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L48</accession>
    <name>Q63L48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sensor kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111173.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1160"/>
    <dbReference type="EnsemblBacteria" id="CAH38628">
        <property type="protein sequence ID" value="CAH38628"/>
        <property type="gene ID" value="BPSS1160"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1160"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5322"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PEQWRRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CHASE" evidence="8">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="364"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="443"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="655" mass="70651" checksum="598E2CFE03A28285" modified="2004-10-25" version="1">MAVAALGVAASYGVARLVLQQERHAAQARFERRAAHMTTTLRQELLTTATVLRGARGMLGERASPASVGWTNYQAQLDLDRARSPIRSLGFVDAKTVIGAGAQTGADPQTRAALLRAADSGLATLDAHAAPSDGAYAPDSGAGALALYLPVYAANGPLPAAERRRADTAGFVVATLDARRLVELSSANDRDIDLRLSAGEAGLLVYTTERDYSGADASHPPLVRTDSLNFGGTPLTLAYTTENRWAAIRSNAVATTVFVAGAATSALLAVLAYLLVGARERAADDSPLNEARMMGIIRSSMEAIITVDETQTIVIFNPAAERVFGVSAMDAIGSPLARFIPERFRAAHAKHVEQFGVTGVSERQMGRQRVLFGLRENGEEFPIEASISQIRDGSGKLYTVMLRDVTERVRNENALRQSREELRELSANLQNVREEEKTRIARELHDDLGQQLTALKMDVSAVAIALARYRDTQADAPPIAAVEQQLHGMRRLIDSTVASVRRIAADLRPVMLDDLGLVPAIEWLVNDFTNRYGIDVERRLDTADTSFSNAGATTLFRIVQEALTNVARHADATRVDLTLAIDQDFCLLQIRDDGRGVPSDERRDANGDKSFGLIGIRERAHMLSGTVTIDSAPGQGFSIKVALPLAAIRQTDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L51</accession>
    <name>Q63L51_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative respiratory nitrate reductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narJ</name>
        <name evidence="2" type="ordered locus">BPSS1157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009971854.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111170.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1157"/>
    <dbReference type="EnsemblBacteria" id="CAH38625">
        <property type="protein sequence ID" value="CAH38625"/>
        <property type="gene ID" value="BPSS1157"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1157"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4382"/>
    <dbReference type="eggNOG" id="COG2180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYSFVVG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="24940" checksum="CDCFD0A8440B3F12" modified="2004-10-25" version="1">MSDAPAAPRGAVYSALSALLDYPEDALVDALPAIDACVRDAKGLTKDARAGLARLIAYLGERDLLTLQENYVALFDRGRATSLHLFEHVHGESRDRGQAMVDLLRMYERHGLYLSAHALPDYLPVFLEYLSRLPERDARNLLTETAQILQALAAALAKRGSHYAFAIGALLSLAGKGPPDVPAAPDDDAHPTVDHRVLDADYTDEPVRFVGAATPGAEPVRFYDKRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L90</accession>
    <name>Q63L90_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539146.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111131.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1118"/>
    <dbReference type="EnsemblBacteria" id="CAH38586">
        <property type="protein sequence ID" value="CAH38586"/>
        <property type="gene ID" value="BPSS1118"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1118"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4335"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVYLGQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="61"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="38933" checksum="89D9B3BA50258DB5" modified="2004-10-25" version="1">MGRRLLLALALLAFIFGGLFLWRESRVQAADHPPAPPAALTVSAVAVRAAPERVTLDAVGSLDAVRQLTLAPEVAGRVVALQFDAGSAVRKGQLIVQLFDEPERAKLASIQAKAAYAKRQLDRSQALAQTGAEPRNLFDRHRFDFDAAAADIRETQAVITQKAVRAPFDGVLGLRRVNLGQYLNAGDAIATLTDLDTLYANFTVPQKNLSQLRLGQSVSITTDAYPERTLVARVSAIEPQIGTDTRNVAVQATLPNPDHLLRPGMYIQARLELPPREHALTVPDTAVQTSQRGESVLVVGKPGRDGLGVVRLQPVRTGRRADGRIAIADGLRPGDVVVTSGQVRLAAGDRVKVALDDGAGSGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LC4</accession>
    <name>Q63LC4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage major tail tube protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205533.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111097.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1085"/>
    <dbReference type="EnsemblBacteria" id="CAH38552">
        <property type="protein sequence ID" value="CAH38552"/>
        <property type="gene ID" value="BPSS1085"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1085"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4283"/>
    <dbReference type="eggNOG" id="COG3498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNNWQGL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006498">
        <property type="entry name" value="Tail_tube"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35861:SF2">
        <property type="entry name" value="PTHR35861:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04985">
        <property type="entry name" value="Phage_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01611">
        <property type="entry name" value="tail_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="18986" checksum="C6E748A885A11613" modified="2004-10-25" version="1">MGMPRKLKGFNVFHNGANFVGEVEELNLPKLKRKMEAWQGSGMTGPVKIDYGSEELQLEWTCGGFMVEVLEQYGAVQHDGVLLRFAGGYRREDSKKHDQIEVVVKGRHEEIDMGTAKAKEDTKFKITTNASYYKLTVNGRDLIELDCVNAVEKINGMDLASDLRRAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LE2</accession>
    <name>Q63LE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009971798.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111079.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1068"/>
    <dbReference type="EnsemblBacteria" id="CAH38534">
        <property type="protein sequence ID" value="CAH38534"/>
        <property type="gene ID" value="BPSS1068"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1068"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4265"/>
    <dbReference type="eggNOG" id="ENOG5030XG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWREIAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="9306" checksum="4DA4DFA14A99355D" modified="2004-10-25" version="1">MARPLYRIRQFAQSRVRGGKLFCVGACQVQQRVAGLFWLEIAYCSDRTGAEAAIRAAVIARRRARLKPRVLGLFDRDGQALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LH7</accession>
    <name>Q63LH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528289.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111044.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38499">
        <property type="protein sequence ID" value="CAH38499"/>
        <property type="gene ID" value="BPSS1038"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1038"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4226"/>
    <dbReference type="eggNOG" id="ENOG5030VXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAITWHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025421">
        <property type="entry name" value="DUF4148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13663">
        <property type="entry name" value="DUF4148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266132" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="90" mass="9596" checksum="BEC9DD17E8BDFF9D" modified="2004-10-25" version="1">MNTKTTIVWATAAALTALALSPAAFAQGKTRDEVRQELIRAQHEGVVPAGKNDYPPSAALVARNKELHAISVHGGKTDLALDQHDQTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LI1</accession>
    <name>Q63LI1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111040.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1034"/>
    <dbReference type="EnsemblBacteria" id="CAH38495">
        <property type="protein sequence ID" value="CAH38495"/>
        <property type="gene ID" value="BPSS1034"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1034"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5166"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MYAGYLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="246" mass="27335" checksum="D1447609F80BCD10" modified="2004-10-25" version="1">MRRTGVFAMEHEVRPSMATTRRHATATALAAAARPCAAPHADSFLGILIEVFARVVAALALGVFAYAAYLQWRLDPSRITLILLAVSTTLTVGLSLFAEPPKKRDWSPLALFFSVGGTFYYLVFQLTASRQLLPEAAGAAIQLIGLFWQLFAKVSLRKSFGILPANRGIVSRGAYRFVRHPMYLGYLIIDAGFLLTNFSARNLIAVALQIGLQLGRIRREERLLSEDAAYRAYRRSVRYRVIPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LK1</accession>
    <name>Q63LK1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528269.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111020.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1014"/>
    <dbReference type="EnsemblBacteria" id="CAH38475">
        <property type="protein sequence ID" value="CAH38475"/>
        <property type="gene ID" value="BPSS1014"/>
    </dbReference>
    <dbReference type="GeneID" id="56597385"/>
    <dbReference type="KEGG" id="bps:BPSS1014"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4193"/>
    <dbReference type="eggNOG" id="COG3448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRCLHPP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="397" mass="41736" checksum="A3DCF90A3C8D4DFF" modified="2004-10-25" version="1">MSSSLAFAHRLARGLVRWLWRFVPIPVTLSRRERVRSCAGALVGIGCVGVTMRALPGLPGDVPLLVAPMGASAVLLFAVPASPLAQPWSLIGGNLVAATVGVACAQWIADPVLAASVAIAGAIGAMFALRCVHPPSGAVALTAVVGGPAVHALGFRFVAEPIALQSAALLGAALVYHALTGHRYPHGGAARPHADSNAHAAAAPLHARFVRADLEAALKNRSEWLDVAPEDLESLLRETELRAYARTFDELSCAEIMSRRPISIAPDTPLPAAMTLLERHRIKALPVVDADARVVGIVTRADLSKAAPYATPGFLRNLSARLPRSLVGPAFVARAVMSTRVHTVRTTTPIAELVPLFADHGHHHIPVVDADHQLAGIVTQADLIAGLYRQSQVRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LP8</accession>
    <name>Q63LP8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110973.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0965"/>
    <dbReference type="EnsemblBacteria" id="CAH38427">
        <property type="protein sequence ID" value="CAH38427"/>
        <property type="gene ID" value="BPSS0965"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0965"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5080"/>
    <dbReference type="eggNOG" id="COG2140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HPNNDEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266562" evidence="6">
        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="88"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="266"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="420" mass="45903" checksum="3A38B099032F96A2" modified="2004-10-25" version="1">MNMTNLSRRKMLAGTAGALAAAGIAVSAKAASFGNPDSPAEGAVNARNPQSLTDPGPQNPALMKEFPSFQSPPATDINGMPIFWASFNNAHKRIQNGGWAREVTQEDFAISETISGVNMRLARGGIREMHWHQQAEWAFMLDGRCRITVLDEEGRPSVQDVKTGDLWYFPPGLPHSLQGLGVDGAEFLLAFDNGRASEFNTLLVTDWIAHTPPDVLALNFGVPADAFRRIPLDNLWIFQGDDPGPLAAAQRASASSRGAPKHPFIFSMGDMKPNVKTRGGEVRIVDSTNFAVSKTIAAALVTVRPGGMRELHWHPNADEWQYYIRGDARMTVFDTGPKAQTADFRAGDVGYVKKSLGHYVQNTGTTDLVFLEIFKADRYAEVSLSDWLAHTPPQLVEAHLHIAPDVIARFPRNRPDVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LU3</accession>
    <name>Q63LU3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205484.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110928.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0919"/>
    <dbReference type="EnsemblBacteria" id="CAH38381">
        <property type="protein sequence ID" value="CAH38381"/>
        <property type="gene ID" value="BPSS0919"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0919"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7217"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALMLPDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="303" mass="31399" checksum="0CC561F3BF1BCB10" modified="2004-10-25" version="1">MNFDVVIIGGSFAGQAAALQLARARRGVLLIDAKRPRNRFARTSHGFLGQDGHAPSAINATAGRQLAAYPTVQFDAGDAIDAAAVSDGFRVSLADGRQAQGRRLILATGVRDILPALPGLQERWGVSVLHCPYCHGYELERRPMGVLASSEQAVHQAMLVSDWGPTTLFTQGAFVPTREQSAMLSARGVTVEQTPVAALVGAAPALEAVCLADGRTAALCGLFIAPRTVPACDLPERLGCVFDDGPTGPYLSVDERQQTSVPGVFAAGDVARPVANATLAAAAGVIAAAGAHHSLIYGAGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LY5</accession>
    <name>Q63LY5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-ethylmaleimide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184894.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110886.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63LY5"/>
    <dbReference type="STRING" id="272560.BPSS0877"/>
    <dbReference type="EnsemblBacteria" id="CAH38339">
        <property type="protein sequence ID" value="CAH38339"/>
        <property type="gene ID" value="BPSS0877"/>
    </dbReference>
    <dbReference type="GeneID" id="56597237"/>
    <dbReference type="KEGG" id="bps:BPSS0877"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7168"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWFIANP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="37538" checksum="4472409CDA3617E6" modified="2004-10-25" version="1">MPSLFDPLTIGDLTLANRIIMAPLTRARAGDTRTPNALMARYYAERASAGLIISEATSVTPQGVGYASTPGIWSPEQVDGWRLVTDAVHAAGGRIFLQLWHVGRVSDPVFLDGALPVAPSAIAPGGHVSLVRPQRPYVTPRALELDEIPGVVAAFRRGAENARAAGFDGVEVHGANGYLLDQFLQDSANRRTDAYGGSIENRARLLLEVVDAAIDVWSAARVGVHLAPRGDAHTMGDSDPAATFGHVARELGRRRIAFLFARESFGGDAIGQQLKAAFGGPFIVNENFTLDSAQAALDAGQADAVAWGKLFIANPDLPRRFKLNAPLNEPNAATFYAQGEVGYTDYPALESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M54</accession>
    <name>Q63M54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroP</name>
        <name evidence="8" type="ordered locus">BPSS0807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523917.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110817.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0807"/>
    <dbReference type="EnsemblBacteria" id="CAH38268">
        <property type="protein sequence ID" value="CAH38268"/>
        <property type="gene ID" value="BPSS0807"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0807"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7072"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIMYLTP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="461" mass="49714" checksum="B4077180EFAF1DDC" modified="2004-10-25" version="1">MATDQDNDGLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIRMAGPSVLLGYALAGVVAFFIMRQLGEMVVDEPVAGSFSYFASKYCGHFTGFLSGWNYWVLYVLVSMAELSAVGIYVQYWWPGVPTWISALVFFVVINAVNLASVKSYGETEFWFSIVKVAAIIGMIGFGGYLLLSGHAGPDAGVANLWRHGGFFPNGIGGLAMAMAVIMFSFGGLELVGITAAEADDPSHSIPRATNQVIYRILIFYIGALGVLLSLYPWQKVVTGGSPFVLIFHALSSDIAASVLNVVVLTAALSVYNSCVYCNSRMLYGLAQQGNAPQALARVNRRGIPIAALGVSAFATALCVVINYFMPGKAFELLMGLVVSAIIINWAMISVIHLRFRQAKRAAGETTRFRSLGYPLTNYFCLAFMAAILVVMFRTPELRLSVYLIPVWLVVLALGYRFRQRGAGYALGGGVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA9</accession>
    <name>Q63MA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family S58 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532874.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110762.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0751"/>
    <dbReference type="MEROPS" id="P01.003"/>
    <dbReference type="EnsemblBacteria" id="CAH38211">
        <property type="protein sequence ID" value="CAH38211"/>
        <property type="gene ID" value="BPSS0751"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0751"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6989"/>
    <dbReference type="eggNOG" id="COG3191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHAAIFK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="376" mass="38622" checksum="8D21C099EDB03FED" modified="2004-10-25" version="1">MRTRDLGIRIGRGKPGRLNAITDVAGVRVGHHTVHVEAGDASAHTGVTVIEPRAARARDEPCFAGVHVLNGNGDATGLEWIREAGLLTTPIAYTNTHSVGIVRDALVAAERAQGGAREREHVYWCMPVVMETFDGLLNDIWGQHVCVGHVAQALAAARSGPVAEGCVGGGTGMICHEFKGGIGTASRIVAEAAGGWTVGALVQANYGQRAALRVAGYPVGEVLRDAHSPFDEAGGAGEPGMGSIVVTLATDAPLLPHQCTRLAQRASVGLARVGGGTDNSSGDIFVAFATGNTGLPIASYGRPGPTTVGVRMVADAHISALFDAAAEAVEEAIVNALVAATDLAARGVRVEALGAARLVDALRETGWRPRAGDAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MB5</accession>
    <name>Q63MB5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110756.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0745"/>
    <dbReference type="EnsemblBacteria" id="CAH38205">
        <property type="protein sequence ID" value="CAH38205"/>
        <property type="gene ID" value="BPSS0745"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0745"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6980"/>
    <dbReference type="eggNOG" id="ENOG5032TW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTHCSAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="17717" checksum="6D219F73B64D9172" modified="2004-10-25" version="1">MWLPRQHVDWSTGKPDPTAEDFKSHCSAFAAAMGARLDVYMLRPPEHSQILLANAQAAWLASDSGRAAGWRELHEAYEAQAAANRGELVVAAFQSADPKMPGHMAIIRPSLKSNVQLADEGPEIIQAGAVNRLDWNVRDGFARHPGAWPNGIKYFAHVVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ME1</accession>
    <name>Q63ME1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110730.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0716"/>
    <dbReference type="ESTHER" id="burps-q63me1">
        <property type="family name" value="CarbLipBact_2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38176">
        <property type="protein sequence ID" value="CAH38176"/>
        <property type="gene ID" value="BPSS0716"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0716"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4769"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWYAEVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="14"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="31406" checksum="043394605E8CF427" modified="2004-10-25" version="1">MNERARAMTGRTGILLIHGLGGTQYDLGSLHKAMRRAGGDTHMITLPGHGTRPEDLVDVRAEAWLDAVTAQYRALEREYDTVHVAGMCMGALVALLLCRRVRHARGRLALLAAPMFIDGWSTPWYRSLRHLLYRVPGVPARLRVDEDEPFGIKNPTIRAIVKKKFERQDNFHYPWVPLACIRQVDRLRSWARAAAADTHCPTLVLHAREDELTSLRSADFLLKHLPDARGIVLENSYHMICADNDRDEVARQVLTFFGFDPSHAMSPAMARRMGRADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MK4</accession>
    <name>Q63MK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205440.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110667.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0648"/>
    <dbReference type="EnsemblBacteria" id="CAH38105">
        <property type="protein sequence ID" value="CAH38105"/>
        <property type="gene ID" value="BPSS0648"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0648"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6843"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTFEFGI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="215"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="318" mass="34896" checksum="55188BCD419DB8FF" modified="2004-10-25" version="1">MHPHLVVALAYDRLCTFEFGCVVELFALPRPELGVDWYRFAVCASEPGPVRAAGGIKVQAPYRLALMDRADTIVIPGWRDPDETPPEPLLKKLRAAHRRGARLCSICSGVFVLAAAGVLDGATVTTHWRYAERLRARYPALRVNPDALYVDAGRIVTSAGSAAGLDMLMHLVRRDHGSAIANRVAQRLVLPPHRDGGQAQFVPRPLPSVGGDRLAKLIDWMRTHAGQPHTLASLAARAAMSPRTLQRQFRDATGLGPYEWLIRERVGLAKEMIERDPALPVARVAALAGFGSEESLRRHFRRIAATSPAAYRRSFDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MN6</accession>
    <name>Q63MN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110635.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0614"/>
    <dbReference type="EnsemblBacteria" id="CAH38071">
        <property type="protein sequence ID" value="CAH38071"/>
        <property type="gene ID" value="BPSS0614"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0614"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6797"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="28685" checksum="81390380ED59E76F" modified="2004-10-25" version="1">MGFTFGFGSLLFVFALFLVASSIRIFREYERGVVFLLGRFWKVKGPGLVLIVPVIQQAVRIDLRTVVFDVPAQDVITRDNVSVKVSAVVYFRVVDPEKAVIQVARYFDATSQLAQTTLRAVLGKHELDALLAEREQLNADIQKTLDAQTDAWGIKVSTVEIKHVDLNETMIRAIARQAEAERERRAKVIHAEGELQASEQLLKAAQRLALQPQAMQLRYLQTLTTIAADKNSTIVFPLPIDLLSSVLERFGRAPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MX0</accession>
    <name>Q63MX0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4150 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190606.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110549.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0528"/>
    <dbReference type="EnsemblBacteria" id="CAH37985">
        <property type="protein sequence ID" value="CAH37985"/>
        <property type="gene ID" value="BPSS0528"/>
    </dbReference>
    <dbReference type="GeneID" id="56531023"/>
    <dbReference type="KEGG" id="bps:BPSS0528"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6689"/>
    <dbReference type="eggNOG" id="ENOG50333NR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ILIMGMP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025425">
        <property type="entry name" value="Tox_PAAR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13665">
        <property type="entry name" value="DUF4150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4150" evidence="1">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="129" mass="13028" checksum="9EE210510F5DBD38" modified="2004-10-25" version="1">MFANCSAGGMAIAPGNDVCKTPPLAIPIPYPNIANKPEAVPNVPNILINGGPAHNLNTIIPVTHSDEGGSMGGVASGTVSGPSRHAKGSSKVMIQGAPETRLTDTNLPNNQNTAGFSAVPSQTITMTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N76</accession>
    <name>Q63N76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate cytidylyltransferase (O-antigen-related)</fullName>
            <ecNumber evidence="3">2.7.7.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rfbF</name>
        <name evidence="3" type="ordered locus">BPSS0419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.33" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551345.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110443.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0419"/>
    <dbReference type="EnsemblBacteria" id="CAH37875">
        <property type="protein sequence ID" value="CAH37875"/>
        <property type="gene ID" value="BPSS0419"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0419"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6555"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWRAIDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="29432" checksum="B962731A1772AE41" modified="2004-10-25" version="1">MKAVILAGGFGTRFTEETISRPKPMIEIGGKPILWHILKLYSHHGINEFIICCGYRGYVIKEYFANYFLHMSDVTFDVQKNSMEVHYRYSEPWRVTLVDTGEMTMTGGRIRRVRQYVEGDDMFCLTYGDGLCDVDLGRLIAFHREHGGKATLTAVHPPARFGVLDIGADRQVIDFTEKPRIDGGMINGGFFVLSPSVIDLIDGDATVWEREPLERLARANELKAYPHDGFWQCMDTLRDKLLLDSMWATGTAPWKKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NH6</accession>
    <name>Q63NH6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531458.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110343.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0323"/>
    <dbReference type="EnsemblBacteria" id="CAH37771">
        <property type="protein sequence ID" value="CAH37771"/>
        <property type="gene ID" value="BPSS0323"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0323"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6439"/>
    <dbReference type="eggNOG" id="COG1556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSRYIAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="144"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="24359" checksum="305928541DC02489" modified="2004-10-25" version="1">MSARDDILGRIRAALGSERARLAAQFPAPVQAKGAGASAAPNANAAFAPDASLSTASSAARGSAISLGDVDLVARFVAKAQQVSATCTHIATAAGAPAAVDAYLRDAGLADAPLVVAAALDALPWRAHRALPGVDLRRDGLVSVTPSFAAIAETGSVVCLSSSATPTSLNFVAATHVVLVNRSAIVATMEDAWARVRATIATLPRAVNVITGPSRTADVEQTVQVGVHGPKRVLVLICDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NP9</accession>
    <name>Q63NP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544944.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110270.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0251"/>
    <dbReference type="EnsemblBacteria" id="CAH37697">
        <property type="protein sequence ID" value="CAH37697"/>
        <property type="gene ID" value="BPSS0251"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0251"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4217"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANPYVDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="170" mass="17236" checksum="EF6DF956C526E832" modified="2004-10-25" version="1">MADALARVALRQQGPRRHLMPVGLIGPRDATGEQLRIAEGVARALAATGLVIVGGGKGGVMEAAARGARRANGLVIGLLPEDDAGGANPHLSVALPTGLGITRNALIARASLCLVAVGGGLGTLSEIALGLQWGKPVFTICDAPQVTGVENFDAPDRLLARVAQWLADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P64</accession>
    <name>Q63P64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523721.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110105.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0081"/>
    <dbReference type="EnsemblBacteria" id="CAH37527">
        <property type="protein sequence ID" value="CAH37527"/>
        <property type="gene ID" value="BPSS0081"/>
    </dbReference>
    <dbReference type="GeneID" id="56531471"/>
    <dbReference type="GeneID" id="66548877"/>
    <dbReference type="KEGG" id="bps:BPSS0081"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6100"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRHTSCS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="139" mass="15754" checksum="B34586F81A15672A" modified="2004-10-25" version="1">MQQSIQHITVEARGRGLVEFTPQVRAFVEVQSVSTGLLTVFCRHTSASLLIQENADPSVQRDIERYFAALAPEDDARYEHDTEGADDMPAHLRTALTQVQLSIPVEHGRMVLGTWQGIYLFEHRRAPHRRDVVLHLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PK0</accession>
    <name>Q63PK0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL3374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545343.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109969.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3374"/>
    <dbReference type="EnsemblBacteria" id="CAH37387">
        <property type="protein sequence ID" value="CAH37387"/>
        <property type="gene ID" value="BPSL3374"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3374"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1823"/>
    <dbReference type="eggNOG" id="COG3594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KVVHFAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="4"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="392" mass="41140" checksum="3A77A4BDE2279EE5" modified="2004-10-25" version="1">MRDSYLDTARGAGIILVVYGHVLRGLFSAGLVPAGWPSALLAATDYTIYTFHMPLFFLLSGLHVPKSLRRAGDVFLLTKLRTIVYPYFVWSLLQGAVQIALSARGTNHAFTPNDLLAIGWRPFGQFWFLYALFICMLIAWAVSAITLRARTHGGASGANGENGGTEVSGENGEPSGAPCAVPAMPIVLVLLAIGGLAAVAFVAGSATRWGIVSMTFAYFPFFVLGMLIGERLPAFLERVSSGPALVAVAATFAASVAFAHRFGESDSIWALPAALSGSALVLLVAHRAARRGDAARHAPRASWLEYLGFASMPIYLAHILATAATRIALVTLGIVDVGAQLALGTFAGVLGPTLLYALALRAGTARLAGFPPLPAGYAMTPDKGRIGRADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PP6</accession>
    <name>Q63PP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109923.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3327"/>
    <dbReference type="EnsemblBacteria" id="CAH37340">
        <property type="protein sequence ID" value="CAH37340"/>
        <property type="gene ID" value="BPSL3327"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3327"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3781"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMTYTPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="254" mass="25515" checksum="285C490DDB548E28" modified="2004-10-25" version="1">MTMFSERCLAGGTYLVTGASSGIGRAAAIAIAQLGGRLVLGGRDPARLADTLAALPGDGHASHAAALDDADAAADWVGALAETHGPLAGVFHAAGVELIRPARMTAQAQLEQVFGASLYAAFGIARAAAKKNVIADGGSVVYMSSVAGSTGQVGMTAYSAAKAGIEGLVRSLACELAPRRIRANAIAAGAVKTEMHARLTRGTPEDALAAYEASHLLGFGEPGDVAAAAIFLLSGASRWITGTSLVVDGGYKVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q29</accession>
    <name>RL30_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmD</name>
        <name type="ordered locus">BPSL3195</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202755.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109789.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q29"/>
    <dbReference type="SMR" id="Q63Q29"/>
    <dbReference type="STRING" id="272560.BPSL3195"/>
    <dbReference type="EnsemblBacteria" id="CAH37206">
        <property type="protein sequence ID" value="CAH37206"/>
        <property type="gene ID" value="BPSL3195"/>
    </dbReference>
    <dbReference type="GeneID" id="56594561"/>
    <dbReference type="GeneID" id="67433086"/>
    <dbReference type="KEGG" id="bps:BPSL3195"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2043"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="PRO" id="PR:Q63Q29"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000273759" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="60" mass="6621" checksum="F77136A99A2CB701" modified="2004-10-25" version="1">MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q81</accession>
    <name>Q63Q81_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL3144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109737.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3144"/>
    <dbReference type="EnsemblBacteria" id="CAH37154">
        <property type="protein sequence ID" value="CAH37154"/>
        <property type="gene ID" value="BPSL3144"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3144"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3593"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="34765" checksum="FC8858B7731D63B1" modified="2004-10-25" version="1">MPRSVMSAIEIRHVKKRYKSLQALKGVSLSVEEGEFFGLLGPNGAGKTTLISILAGLARADEGTIAVRGHDVVKDFRAARRALGVVPQELVFDPFFTVRETLRIQSGYFGLHRNDDWIDEVMANLDLTDKADANMRALSGGMKRRVLVAQALVHRPPVIVLDEPTAGVDVELRQTLWKFISRLNREGHTIVLTTHYLEEAESLCDRIAMLRRGEVVALDHTRTLLQRFSGLQLFVRLSHGALPAELRALEAEPAPAAQPEHLLRITDYDEVERILSLCRAAGCGFDEIEIRKADLEDVFVQVMNGADVIEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QC6</accession>
    <name>Q63QC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555848.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109692.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3097"/>
    <dbReference type="EnsemblBacteria" id="CAH37108">
        <property type="protein sequence ID" value="CAH37108"/>
        <property type="gene ID" value="BPSL3097"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3097"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2146"/>
    <dbReference type="eggNOG" id="COG3523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NFVREFM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009612">
        <property type="entry name" value="IcmF-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010623">
        <property type="entry name" value="IcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017731">
        <property type="entry name" value="TssM1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06761">
        <property type="entry name" value="IcmF-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06744">
        <property type="entry name" value="IcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03348">
        <property type="entry name" value="VI_IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="6">
        <location>
            <begin position="190"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related" evidence="5">
        <location>
            <begin position="494"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF_C" evidence="4">
        <location>
            <begin position="1130"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1297" mass="142076" checksum="D918A8339A5A52FD" modified="2004-10-25" version="1">MQRFLNVLTHPRTLTIVGFAALAAVLFIAADALQIGLVWAAVALGVALALWLATKLWRRWRVRRANRQLGDMLEQQAETGKMSAAVAEPAKRAELDVLRTRLADTVKTIKTSKIGQVSGGSALYELPWYIVIGNPAAGKSSAVINSGLQFPFADKNSAVIHGIGGTRNCDWFFTTEGILLDTAGRYSVHEEDRSEWLGFLDLLKRYRPKAPINGIIVTASIAELTGNRPEFAINLAKNLRQRVQELTEKLEVFAPVYVMFTKADLITGFTEFFSSNDRQEYDRVWGATLPYEPDEKRDVVALFDQRFEELYDGLKEISVAQLSVSRGNKLSPGQLSFPLEFSTIKPALRSFLATLFEDNPFQYKPIFRGFYFTSALQEGETNSAAAQRIAHRFGLNSQSLPKPHSAFSKNGFFLRDLFSKVIFADRQTVRQFASPTKTRVRYATFFGFVAALALALGGWTWSTIGNQQLVSNVQADLDNVTRLQQNRNDLQSRLQAMDILEDRIEQLEQFRRDKPLSVSLGLYQGNRLEQHLLTEYYNGVRQILLAPVSDNLASFLKDVNAHPDQLAPMTRAPESGATPAGPMPVSTHPAAPGAAPSPAVAQGRQQGGLYNDASPTNVEDAYNALKTYLMLSDKRHVEQAHLTDQVARFWRGWLETNRGNMPRDEMIRSAERMITFYLSRVSDNDWPMIEANLALVDQTRENLRRVVRGMPARQRVYEEIKARASTRFAPMTIARIVGEGNTGLVAGSYAIPGTFTRDAWFQYVQPAIRDAATKELQAKDWVLNTASADDLTLEGSPEQIQKTLVAMYKTEYAQHWQKFMQGIAVQGFGNFTQAVDAMNKLGDPQDSPIRKVLETAYDQTSWDNPSLANATIKKAQTGVVNWVKQWFTRQPGGQIAANVDINGNPADVPMGPIGQEFVGLGRIVATHDGTSMLKGYMDTLSKVRTRFNVIKNQGDPGPGARQLMQQTLDGNGSELADSLKFVDEQMLTGLTDSQRKSLRPLLVRPLMQAFAVVIQPASVEVNKVWNAQVYQPFQNSLANKYPFAAGAKVEAGAGEIAQVFGPDGSIAKFVGTTLGPLAVRRGDTLSARTWGDMGLALTPDFTGGFARWVAPLAGGAATSAAASSEPQTVFQVLPQPSSGTTEYTIAIDGQQLRYRNTPPQWTNFVWPNPQGSPGATLSATTFDGRTLQLVNEPGRYGLEKLINSAQRKRRPDGTFDLTWTQGSVSVSVTMRIISTSQPTGGGDQPQQQSLRGLRLPSSVADASAGGAANATAQPGSGAAAAQVAATAASASNAQGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QD4</accession>
    <name>Q63QD4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL3089</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004204896.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109684.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3089"/>
    <dbReference type="EnsemblBacteria" id="CAH37100">
        <property type="protein sequence ID" value="CAH37100"/>
        <property type="gene ID" value="BPSL3089"/>
    </dbReference>
    <dbReference type="GeneID" id="56528098"/>
    <dbReference type="KEGG" id="bps:BPSL3089"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2159"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267446" description="Aminopeptidase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="323"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH37100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="721" mass="79093" checksum="DC2C11541D53CDC0" modified="2004-10-25" version="1">MWINNRRLRYLSLLGALALAACGGDDGGTGSAVSLGAAHSPSNGANGANGTNGGAATPAAVDKSTKPVEMPDTVVPVNYKLWFRPNADLNQFSGRADVEIKVLKPVNAIVVAGHRIQFTNGKTTLQPGNVQLVATPQDKGDFYQLRPASGQIAPGNYSLHMEWQGIINFKSYDDPVNHTGGSCGNDPYPGCSAAEGIFRVDLKSTDGTTSGAILTQGETNLSRQWFPGWDEPAFRPTYEVTAEVPQAWRVVSNAAELPSVNVGGGYKLVSFEKTPPMPSYLLFFGGGLFDVLEDDFSSPLPNSNGLHLRIFTPPGMREWARPAMQRTKQALDYYYRYTGIALPLKKFDTVAANDAFKDQKGLNFGGMENWGSILEFADDILPEPGKPMSRYGNQVLTHEVAHQWFGDLVTTDWWDDVWLNESFARFFETKTTIQFFPDEFNWLDHIKSKYRVINKDISQDAFPIQPNFNGWASNDFVISASSFVYNKGGMVLKMLEGYLGEQTLRKGLQQYLNDYAFGNGTPKRLWDALSAASGQQVGPIGDSFVRQTGVPLLALDTQCDLTKNQNVVTLTQSPFPNKNKYPGAQWTIPVTLAYGDGLVNRKTLALKDTQTQIRLDGCSAVVANPTGFDYYVTNYSDAAWSALLTQINASTDPVLLLNLKSEAALLVASNLAPPSRATSISSINSPAAMKLRQVPSILETPKERPQLRYQGKFTPRQQRTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QG0</accession>
    <name>NUOB2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit B 2</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit B 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit B 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoB2</name>
        <name type="ordered locus">BPSL3063</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186860.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109658.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QG0"/>
    <dbReference type="SMR" id="Q63QG0"/>
    <dbReference type="STRING" id="272560.BPSL3063"/>
    <dbReference type="EnsemblBacteria" id="CAH37074">
        <property type="protein sequence ID" value="CAH37074"/>
        <property type="gene ID" value="BPSL3063"/>
    </dbReference>
    <dbReference type="GeneID" id="56597076"/>
    <dbReference type="KEGG" id="bps:BPSL3063"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2199"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RENTANV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000358381" description="NADH-quinone oxidoreductase subunit B 2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <sequence length="167" mass="18469" checksum="DFF69B102604E50B" modified="2004-10-25" version="1">MANHPLTLEKDGFIVTTLDAAMAAAQKNSLWYMTFGLACCAVEMMHAAGARYDMDRFGMIPRASPRQCDLMIVAGTLTNKMAPAMRRVYDQMAEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGLMQLQRKVAERSTHSRPKLFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM8</accession>
    <name>Q63QM8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ffh</name>
        <name evidence="12" type="ordered locus">BPSL2995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194338.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109590.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2995"/>
    <dbReference type="EnsemblBacteria" id="CAH37006">
        <property type="protein sequence ID" value="CAH37006"/>
        <property type="gene ID" value="BPSL2995"/>
    </dbReference>
    <dbReference type="GeneID" id="56594248"/>
    <dbReference type="KEGG" id="bps:BPSL2995"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2275"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="103"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="104"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH37006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="455" mass="49195" checksum="52DE570FE7EA80FB" modified="2004-10-25" version="1">MLDNLTQRMARVVKTLRGEARLTEANTQEMLREVRLALLEADVALPVVRDFIAKVKEKALGEDVIGSLSPGQALVGVVQKELTAVIGGDYEGKAAELNLAVAPPAIILMAGLQGAGKTTTVGKLAKLLREKYKKKVLTVSCDVYRPAAIAQLKTVSEQVGADFFPSTPDQKPVDIANAAVDWAKRHYHDVLLVDTAGRLGIDEAMMQEIAALHAALKPVETLFVVDAMLGQDAVNTAKAFNDALPLTGVVLTKLDGDSRGGAALSVRHVTGKPIKFVGVAEKLDGLEIFHPDRMANRILGMGDILALVEEAQRGVDIQAAEKLANKVKKGGDFDLNDFRAQISQMKNMGGLSSLMDKLPAQFQQAAAGADMSQAEKQIRRMEGIINSMTPAERAKPEIIKATRKRRIAAGAGVPVQEVNRMLNQYDQMRTMMKKLKGGNLQKMMRGIKGMMPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV8</accession>
    <name>Q63QV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109510.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2916"/>
    <dbReference type="EnsemblBacteria" id="CAH36926">
        <property type="protein sequence ID" value="CAH36926"/>
        <property type="gene ID" value="BPSL2916"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2916"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3331"/>
    <dbReference type="eggNOG" id="ENOG50346FP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMLEHCA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="112" mass="12700" checksum="D53A25E9E175994F" modified="2004-10-25" version="1">MLGASHAGVFNAADQAPRPWLKFDCCWETKMLSPHEFATLMLVRHAPDQIDMDRAELDALLERQLVMLEHSAEGRRRAHLTAMGRSLLDAFDPDDHPRRRPAKIHTCGESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R62</accession>
    <name>Q63R62_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109406.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2811"/>
    <dbReference type="EnsemblBacteria" id="CAH36821">
        <property type="protein sequence ID" value="CAH36821"/>
        <property type="gene ID" value="BPSL2811"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2811"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3207"/>
    <dbReference type="eggNOG" id="COG0121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFRHGRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="31856" checksum="8DFAC3150769FED7" modified="2004-10-25" version="1">MLTMCRWLAYTGNPIPLETVLFRAKHSLIDQSLHSRMGATTTNGDGFGIGWYGQPDEVPFIYRCVSPAWNDRNLREAARAIRSPLFVAHVRSATDTPVQETNCHPFRRGRWLFAHNGLIRRYHTLRRDLMMRIDPGLFASIEGSTDSEVMFHLALTFGLEHDPLAALERMAGAIEDAGAHHRVDAPLNMTVCATDGEQVVAVRYSSEHDSRSLFHSTSFRHLHELYPHDPRIRAIGDDAFLVLSEPLVDLHDAWEKIPESTAIIARRGDIRQVPFQPRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU4</accession>
    <name>Q63RU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552545.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109173.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2576"/>
    <dbReference type="EnsemblBacteria" id="CAH36584">
        <property type="protein sequence ID" value="CAH36584"/>
        <property type="gene ID" value="BPSL2576"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2576"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2787"/>
    <dbReference type="OMA" id="ECSAWLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="21407" checksum="025B15757816104C" modified="2004-10-25" version="1">MAVNPKTLEECSAWLKKANALDKARFAAKQAAAKPEGATSLNKALEESRRRAGGPTAADVSKQTGTARFVSWVNGVAKAHDDADRAAAERAAQRMQKGPAPNSGPNSAASNPRAAHVDGSGRTTNAPKAGNGGVASPSAPTSHVGPFVGSNSAAANQRADQVAANGRVSGGLEDPQIGAGRVTPITVASTADGGPAAIFDFFNRRKRKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX0</accession>
    <name>Q63RX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109147.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="TCDB" id="1.E.43.1.11">
        <property type="family name" value="the putative transglycosylase-associated holin (t-a hol) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36558">
        <property type="protein sequence ID" value="CAH36558"/>
        <property type="gene ID" value="BPSL2550"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2550"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2912"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWIMTIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="115" mass="12009" checksum="11C9FC7F257DEE97" modified="2004-10-25" version="1">MCDAPGSACDPSRHRQRPTSVHSWELTKERTTMAHGLIMWLIIGAIAGWLAGLLVKGGGFGLLVDIIVGIVGAVIGGWLAGILGIHIGGGFISSVIVAVIGAVILLFVIRLFKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ7</accession>
    <name>Q63RZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550108.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109120.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2524"/>
    <dbReference type="EnsemblBacteria" id="CAH36531">
        <property type="protein sequence ID" value="CAH36531"/>
        <property type="gene ID" value="BPSL2524"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2524"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2856"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TPHAKPH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006346">
        <property type="entry name" value="PGPase/MupP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01449">
        <property type="entry name" value="PGP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="25135" checksum="366420B3D95FD721" modified="2004-10-25" version="1">MSLSSPSFAAPLSDAPRLDACEAVLFDLDGTLADTAPDLAAAVNKMQRSRGIAQTPLDALRPLASAGARGLIGGAFGIAPADAEFDALRDEFLANYAADLCLHTTLFPGIGALLDDLDARGVRWGIVTNKAARFTDPLVALLGLAARAACVVSGDTASHPKPHPAPLLYAADRLSLAPERIVYVGDDLRDIQAGSAAGMPTVAAAYGYCGDGAAPADWRAQHLVETTDDLQRLLRVLRYNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD7</accession>
    <name>ASTD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-succinylglutamate 5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="1">1.2.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Succinylglutamic semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">SGSD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">astD</name>
        <name type="ordered locus">BPSL2387</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:10812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58520"/>
            <dbReference type="ChEBI" id="CHEBI:58763"/>
            <dbReference type="EC" id="1.2.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family. AstD subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.71" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527437.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108979.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SD7"/>
    <dbReference type="SMR" id="Q63SD7"/>
    <dbReference type="STRING" id="272560.BPSL2387"/>
    <dbReference type="EnsemblBacteria" id="CAH36389">
        <property type="protein sequence ID" value="CAH36389"/>
        <property type="gene ID" value="BPSL2387"/>
    </dbReference>
    <dbReference type="GeneID" id="56528800"/>
    <dbReference type="KEGG" id="bps:BPSL2387"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3015"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWNKQLT"/>
    <dbReference type="UniPathway" id="UPA00185">
        <property type="reaction ID" value="UER00282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043824">
        <property type="term" value="F:succinylglutamate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:arginine catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019545">
        <property type="term" value="P:arginine catabolic process to succinate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07095">
        <property type="entry name" value="ALDH_SGSD_AstD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01174">
        <property type="entry name" value="Aldedh_AstD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017649">
        <property type="entry name" value="SuccinylGlu_semiald_DH_AstD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699:SF197">
        <property type="entry name" value="PTHR11699:SF197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03240">
        <property type="entry name" value="arg_catab_astD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000262389" description="N-succinylglutamate 5-semialdehyde dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01174"/>
        </source>
    </evidence>
    <sequence length="487" mass="51839" checksum="DB57627D1A743BA2" modified="2004-10-25" version="1">MTELFIDGAWRDGAGPVFASRNPGTGEPVWEGAGASADDVERAVASARRAFAAWSALDLDARCAIVKRFAALLVERKEALATMIGRETGKPLWEARTEVASMAAKVDVSIAAYHERTGERRSPTADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARATVEIWRDAGLPAGVLNLVQGEKDTGVALANHRQIDGLFFTGSSDTGTLLHRQFGGRPEIVLALEMGGNNPLVVADVEDIDAAVHHAIQSAFLSAGQRCTCARRILVPRGAFGDRFLERFADVASRITADVYDADPQPFMGAVISARAASRLVAAQAKLLELGAAPIIEMRQRDPALGFVNASILDVTPVRELPDEEHFGPLAQIVRYTDLDDAIARANDTAFGLSAGLLADDETVWNTFRRAIRAGIVNWNRPTNGASSAAPFGGAGRSGNHRPSAYYAADYCAYPMASVESAQLQMPANLSPGLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SF4</accession>
    <name>Q63SF4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SufBD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205166.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108962.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2369"/>
    <dbReference type="EnsemblBacteria" id="CAH36371">
        <property type="protein sequence ID" value="CAH36371"/>
        <property type="gene ID" value="BPSL2369"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2369"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3038"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="484" mass="53172" checksum="903032FFBA2DBACE" modified="2004-10-25" version="1">MLNVDQPTPLARALEQTYRHGFVTDIESDSLPPGLDEGVVREISRRKREPAFLLKWRLAAFERWLAMSPPDWGKLRIAPIDFQAQSYYSAPKSLKDQPKSLDEVDPKLLETYEKLNVPLHERARLAGVAVDAVFDSVSVGTTFREQLAEAGVIFCSFSHAVEHHPELIERYLGTVVPPADNFYAALNSAVFSDGSFVYVPQGVRCPMELSSYFRINAQNTGQFERTLIIAEPGSHVGYLEGCTAPQRDEHQLHAAVVELVAHDDAHIKYSTVQNWYPGDADGVGGIYNFVTKRGLCAGARSRIAWTQIETGSAITWKYPSVVLRGDESSGEFHSIAVSNHCQQADTGTKMIHLGRNTRSRIVSKGISAGRAQNSYRGLVRVARTAEGARNHTQCDSLLIGPQCGAHTFPYVESARGDAVVEHEATTTRISEDLLFYCQQRGIDPQEATALIVGGFCQAVLEALPMEFALEAKALLAVSLEGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SH0</accession>
    <name>Q63SH0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527410.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108946.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2351"/>
    <dbReference type="EnsemblBacteria" id="CAH36354">
        <property type="protein sequence ID" value="CAH36354"/>
        <property type="gene ID" value="BPSL2351"/>
    </dbReference>
    <dbReference type="GeneID" id="56528835"/>
    <dbReference type="KEGG" id="bps:BPSL2351"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3060"/>
    <dbReference type="eggNOG" id="COG3256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TIHTQFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="762" mass="84357" checksum="F713B8805928A1C0" modified="2004-10-25" version="1">MRSTRRLWTWLGLVCLASFAVLLWLGRDIYLAAPPIPNTVVSENGRVIFTGEQIKRGQQVWLASGGQQLGTVWGHGSYVAPDWSADWLHREALELRDAWARQQFGAPYEKLPVDQQGMLDARLKREMRANRYDAANDRLTLSDTRAAAALRVASHYEALFGADPSLDTLRDQYAMTAGAVPGAADRTALASFFFWSAWSATTDRPGETGTTYTNNWPHEPLVGNTPTAANGMWSIASVIILLGAIAAMVWYHTAHGEHDAPLAVPTNDPLFNVKPTPSMRATKKYFYVVIGLLLTQVFMGAITAHYAVEGHSFFGIPLADVMPWVVSRTIHTQFGVLWIATAWLATGLYISPLLSGREPKLQKLGVDVLFWALIFIVVGSTVTGWLGSLKHLGTNFSFWIGNQGLAYTSMGRVWQILLFVGLLFWLFLMGRALMPALKNKATEGRGLIGMVFLSAACIGLFYASSLAWGQNTHYSMIEYWRWWLVHLWVEGFFEVFATAVIALIFARLGLIRFESANRAIVMETIVFLFGGILGTLHHLYFTGATTSIIAVGAVFSACEVVPLALVGFEGWQTYRKSSAAPWIQSYKWAILCFVAVGLWNTVGAGLLGFSINPPISLYYVQGLNMTPAHGHAALFGVYGMLGIGLMLFCLRGMSERNAWRDTLLKPAFWLLNVGLFMMVFLSILPSGIYEAYASVTQGLWYARSPEIVHAPIMNALVWLRVPGDVVFAFGVLYLGWFALRLLRRPAPSQPDERAVGQAAQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SJ1</accession>
    <name>Q63SJ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550172.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108925.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2329"/>
    <dbReference type="EnsemblBacteria" id="CAH36332">
        <property type="protein sequence ID" value="CAH36332"/>
        <property type="gene ID" value="BPSL2329"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2329"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3093"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGDKWFC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="183"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="297"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="597" mass="64870" checksum="9D66C2BF29F5F940" modified="2004-10-25" version="1">MNMMKDTVEANAPAAGAANIPDSRGINFFTSDPDCAALLRLHLGEARFRGFEPELRALGLRASDELDRLASRADRNPPVLQPRTRRGEPLESIDKHPDYVELERVAYAQLGLAAMSHRDGAPPPLVKYALTFLFVQAEFGLCCPVSMTDSLTRTLRRFGSRELVERFLPRLASRDFDVLYQGAMFMTEQAAGSDVGRIATRAVRGTSADGSATWRLFGDKWFCSNADADLAMVLARPEGAPDGVKGLALFLLPKTLADGSRNRYRIVRLKDKLGSRSMASGEIALDGAEAYLIGEIGRGFHQMADMINMSRLSNGVRAAGLMRRATTEALHVARHREAFGRKLIDMPLMQRQLVKMLVPTEQARSLFMQIALLLAKADAGDAQAGGCVRILTPLIKFRACRDARRVAGDAMEVRGGTGYIEEWSDARVLRDAHLGSIWEGTSNIVALDVARAVKREGALAPLRAFLLGALDTARLPGASATRLRRALDRASDAIAHVARTGDDAFVRQAASALYHATTAILLASEGMRLAPDHRRLALAHLVLRYKLSPVDPLATPRADADADAEAEAGVLAALLHDRPVTLDDALRLLDDRSGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SZ4</accession>
    <name>Q63SZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108772.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2177"/>
    <dbReference type="EnsemblBacteria" id="CAH36179">
        <property type="protein sequence ID" value="CAH36179"/>
        <property type="gene ID" value="BPSL2177"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2177"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2473"/>
    <dbReference type="eggNOG" id="ENOG50316QK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACRIVEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021294">
        <property type="entry name" value="DUF2866"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11065">
        <property type="entry name" value="DUF2866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="110" mass="12329" checksum="5E9B08D95CA0F0B9" modified="2004-10-25" version="1">MQPVFFYACPGCLPHDAEKGSVLKRSHQASAQPRTYNVRGCRVSEPIGAPWGGGCRIVEWIGGDGRIARRVAAVNVTEAEVYAMIRRPVEGRRYLMSDDEQMPRDTLPRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T23</accession>
    <name>FABZ_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="1">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ</name>
        <name type="ordered locus">BPSL2148</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH36150" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36150.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192266.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108743.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T23"/>
    <dbReference type="SMR" id="Q63T23"/>
    <dbReference type="STRING" id="272560.BPSL2148"/>
    <dbReference type="EnsemblBacteria" id="CAH36150">
        <property type="protein sequence ID" value="CAH36150"/>
        <property type="gene ID" value="BPSL2148"/>
    </dbReference>
    <dbReference type="GeneID" id="56595933"/>
    <dbReference type="KEGG" id="bps:BPSL2148"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3305"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091656" description="3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="155" mass="17412" checksum="5FEC69C5A1BA23E3" modified="2005-03-29" version="2">MSTEKINFDIHKILTLLPHRYPILLVDRVLELEPHKAIKALKNVTVNEPFFTGHFPKRPVMPGVLIIEALAQAAALLTFAEAQPKDPENTLYYFVGIDNARFKRVVEPGDQLILNVTFERYIRGIWKFKAVAEVDGKVAAEAELMCTVKTADAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TA7</accession>
    <name>Q63TA7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HNS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526737.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108659.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2060"/>
    <dbReference type="EnsemblBacteria" id="CAH36061">
        <property type="protein sequence ID" value="CAH36061"/>
        <property type="gene ID" value="BPSL2060"/>
    </dbReference>
    <dbReference type="GeneID" id="56526423"/>
    <dbReference type="KEGG" id="bps:BPSL2060"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.47"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KWLIGRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="5">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="114" mass="12912" checksum="CAAC113FBF21A134" modified="2004-10-25" version="1">MDHDPQLTERWLEIHAEIEALRRKAKAAAIMQIELLMTQYGISPGELKGVDGAPAHRKPKARYWNPETGQTWSGRGRMPKWLVGRELASHLIDGESALKRMKLLNRDAQDADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TE5</accession>
    <name>Q63TE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component regulatory system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108621.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2024"/>
    <dbReference type="EnsemblBacteria" id="CAH36023">
        <property type="protein sequence ID" value="CAH36023"/>
        <property type="gene ID" value="BPSL2024"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2024"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2284"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LTMHDNE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="21767" checksum="3A42ED654A918378" modified="2004-10-25" version="1">MLIADDHPLVLLGVRHMLAGMGDVSIVGEAHDPAGLLALLAATPCDIVITDFAMPEQPAADGLAMLTAIRDGYPSVRVIVLTMLDNPVLMHTMRQAGALAVLSKRGDLDELPRALAAVYQGRPFVGTHAGAAGGGAMRGTDAPRQLSPREIEVVRLCATGMTMTDIANRYGRSIKTVSTHKHNAMGKLGLKSDVDLFMYATENGLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TG5</accession>
    <name>Y2003_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein BPSL2003</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL2003</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193399.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108601.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TG5"/>
    <dbReference type="SMR" id="Q63TG5"/>
    <dbReference type="STRING" id="272560.BPSL2003"/>
    <dbReference type="EnsemblBacteria" id="CAH36002">
        <property type="protein sequence ID" value="CAH36002"/>
        <property type="gene ID" value="BPSL2003"/>
    </dbReference>
    <dbReference type="GeneID" id="56595393"/>
    <dbReference type="KEGG" id="bps:BPSL2003"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4157"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETRNQAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225816" description="UPF0145 protein BPSL2003">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <sequence length="111" mass="11953" checksum="E003B58E03849F2A" modified="2004-10-25" version="1">MADPQLITTAFDIPGYRIERSLGVARGIVVRSRSIVGTFGASIQTLFGGNISLYTSLCERARQDAYERMIDEARRMGGNAIVGMRYDATEIASGVTEVLCYGTAVQAVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TL0</accession>
    <name>Q63TL0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="Int. J. Biol. Macromol." volume="152" first="1113" last="1124">
            <title>Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.</title>
            <authorList>
                <person name="Sykorova P."/>
                <person name="Novotna J."/>
                <person name="Demo G."/>
                <person name="Pompidor G."/>
                <person name="Dubska E."/>
                <person name="Komarek J."/>
                <person name="Fujdiarova E."/>
                <person name="Houser J."/>
                <person name="Haronikova L."/>
                <person name="Varrot A."/>
                <person name="Shilova N."/>
                <person name="Imberty A."/>
                <person name="Bovin N."/>
                <person name="Pokorna M."/>
                <person name="Wimmerova M."/>
            </authorList>
            <dbReference type="PubMed" id="31751748"/>
            <dbReference type="DOI" id="10.1016/j.ijbiomac.2019.10.200"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-357</scope>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521691.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108556.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="6GXR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=2-357"/>
    </dbReference>
    <dbReference type="SMR" id="Q63TL0"/>
    <dbReference type="STRING" id="272560.BPSL1958"/>
    <dbReference type="EnsemblBacteria" id="CAH35957">
        <property type="protein sequence ID" value="CAH35957"/>
        <property type="gene ID" value="BPSL1958"/>
    </dbReference>
    <dbReference type="GeneID" id="66546921"/>
    <dbReference type="KEGG" id="bps:BPSL1958"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4106"/>
    <dbReference type="eggNOG" id="ENOG5033DS9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLVSWQD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="6GXR"/>
        </source>
    </evidence>
    <sequence length="357" mass="36126" checksum="B8DEEAA4E729DFE5" modified="2004-10-25" version="1">MAKLAASNQFGIPNQTDVFAVDGNGSLRVSWVVSAGAWNGPAQIGPAGLFPSRAAVASSNQFGIPNQTDVFAVGRDGALNVAWVVSADRWNGPTPISAAGLFPAGAAIAASNQFGIPNQTDVFAVSDSGALNVAWVVSAERWNGPIPISAAGHFPAGAPLATSNQFGIPNQTDVFVVDNKGALNVAWVVGAGSWNGPIPISPPGLFPPGAAVAASNQFGIPNQTDVFVVDNQGALNVAWVVGADRWNGPVPISPAGLFPPGAAVAASNQFGIPNQTDVFAVGRDGALRVAWVVSAGNWNGPVSISPTNLFPSGAAVAASNQFGIPNQTDVFAADSDGVLHVAWVVSAGNWNGPISIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U09</accession>
    <name>Q63U09_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521593.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108407.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1808"/>
    <dbReference type="EnsemblBacteria" id="CAH35807">
        <property type="protein sequence ID" value="CAH35807"/>
        <property type="gene ID" value="BPSL1808"/>
    </dbReference>
    <dbReference type="GeneID" id="56595595"/>
    <dbReference type="KEGG" id="bps:BPSL1808"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3928"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWFNIGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="17"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="26098" checksum="936F0C0E623809E5" modified="2004-10-25" version="1">MDAWLAPKYLMWLWQGFLLTLGLSLAAAVTATLAGFALAIARHAKRASPRRAAAAYVVAFRNTPLVVQLLFWYFGVAALLPEPAMAWLNAPHALDVGGLALRWPSFEFVAGWLGLSGYTSAFVAEEFQAGLRGVPAGQHHAASALGLSPLQAFRFVVLPQAVRIALPPLFGQYMNLIKNSSLTMAIGVAELSYASRQVETETFRTFAAFGVSTVLYVAAVALVEAAAQWTLRRRDRTFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U87</accession>
    <name>Q63U87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531283.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108329.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1729"/>
    <dbReference type="EnsemblBacteria" id="CAH35728">
        <property type="protein sequence ID" value="CAH35728"/>
        <property type="gene ID" value="BPSL1729"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1729"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3824"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAWRMLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="28032" checksum="BDAEC0AE722EB764" modified="2004-10-25" version="1">MHRVTHYRRADDGIEAISLDTDRAFPRHAHDEFGVGVIVSGAHRSWSGCGTVDARAGDTIMVNPGEVHDGLPLGARTARSWRMLYLTPALVAGFAAEEGCGGVELAHPAVRDARLAAAVERLFARVVAGAQTPAASIACDEALALLVAALLARHASGRAPRAGSAPAIRIVRERLDASPADAVSLAELASLAGVSRFQLLRGFARELGITPHAYLIQSRARLARALLARGLSIAQAAAEAGFADQSHLTRAFVRQFGITPGRFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U93</accession>
    <name>Q63U93_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534838.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108323.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1723"/>
    <dbReference type="DNASU" id="3094290"/>
    <dbReference type="EnsemblBacteria" id="CAH35722">
        <property type="protein sequence ID" value="CAH35722"/>
        <property type="gene ID" value="BPSL1723"/>
    </dbReference>
    <dbReference type="GeneID" id="56529406"/>
    <dbReference type="KEGG" id="bps:BPSL1723"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3816"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IEVDNQF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="167"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="41142" checksum="A080C49A5F127193" modified="2004-10-25" version="1">MTAATSVRAQAREEDLSVKEILDSRWFQPEMFKTLDYVKGFVGAKVIFQMLKLGVFDDLLAGKTLEEIASGRSLDPYLLRTVFEYLSVEGLLVKEGRGGGASFRLSDYGSRIKHYEGWFNILIGGYDNIFSNIGAMLEEGIGGYKRDGKWVGVGSCQISKYDTIPITKAFIESVKPDAKQIVDFGCGNALYLCTLAKELGDIKAVGIEPDTSAYEAGLKKVAEMGLQDQVRLVNVDALDYEIDEQPDFILFGFVLQEIIAQIGRPAFIEYLRKLGRKFADSYLMVMEVDYDIDNREVMHSPMGRGYYNPYFLLHPFTNQLLLPKREWDEIFAQAGYDVVRDEVTSPKADPSGFGICYVLKYRGAHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UA1</accession>
    <name>Q63UA1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108315.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1715"/>
    <dbReference type="EnsemblBacteria" id="CAH35714">
        <property type="protein sequence ID" value="CAH35714"/>
        <property type="gene ID" value="BPSL1715"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1715"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3807"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFVFIES"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="111"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="894" mass="95007" checksum="A6D49DB6C2CF3987" modified="2004-10-25" version="1">MKTFVFIESNTTGTGRLCLQKALLRGFDVLFVTSRPQLYPFLQEEMVVPLVADTADPQRIADALAPYAGIAGIFSTSEYYIETAATVATRLGLPAADPEAIRTCRDKGRLHRRLRDAGVGVADTEIVSERTQLRDLAHGAAYPRVLKPAFGSGSVGVRLVRTPAEMLAHGERMLDARGNERGIALARQVLVQSFVDGPEFSVEVVGLGAEHGHAVLGVTGKHLGPLPHFVEAGHDFPAPIAAAQRDAIVAETLRALDAVGHRFGPAHVECRVSGGKVVVIEINPRLAGGMIPQAIEWATGVDVLGAMIDLHAGTPPDLGPRRRGHAAIRFVLPARSGELRALSFEPDERFAGVRTRFMPLKQLGQRIEPAGDFRDRLALVIASATDPDALAHALEDVDRCVTVAIGDAGAAGEGAGAGRLRRTLHPEALAIVRKPAPRAERLAELDAFAAIDEAHLLMLVDAGICDRARAATVLAELARQRDAKFAAIADAIAPRGTYALYEQLLIERVGIDAGGAVHTARSRNDINACVAKLRAREWFDTCGGKLWRVRAAIVDKAQHTLDWPLPTYSQYQAAQPGSFGYYLWSVETALRRDQAALERLDEELAVCPLGAGAGAGTDFPIRPGVSAALLGFARSFDSALDAVASRDLVLHFLAAIAIASTTLSRLAHDLQLWTMRETDFLALPDELSGGSSLMPQKKNPYLLEIVKGKLAHVAGALNAAVFASQRTPFSNSVEIGTEMLAPCADAVQAFGESCDLLRLMVSGVTGDPAKMRAAAEAGLVSATQVANALVRETDISFHAAHRQIGALITQALDAHEDPAAALDALVRQPGASIDEAAARLAYGGGPGAAGAGLARSRALLRQSAERLWRRRAAWHAAHARRRGCVADLLAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB4</accession>
    <name>Q63UB4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108302.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35697">
        <property type="protein sequence ID" value="CAH35697"/>
        <property type="gene ID" value="BPSL1699"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1699"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3780"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="10124" checksum="BF9B11DB661B4E61" modified="2004-10-25" version="1">MRSCGIADGGAGVRSASRSQYPHASKWTAGAWSSVSDGSSTEQIGVVGVLPYRAARPSLTIGAKTMSYMANKPSQAVNRLRERAVIKAGAEKCVHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UD6</accession>
    <name>Q63UD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two component system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550438.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108280.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1669"/>
    <dbReference type="EnsemblBacteria" id="CAH35668">
        <property type="protein sequence ID" value="CAH35668"/>
        <property type="gene ID" value="BPSL1669"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1669"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3748"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PNDRSID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="27898" checksum="67BED231013F8B54" modified="2004-10-25" version="1">MVIYLIEDDEIQAQYYQSMLVEHGWQVKLLLDGERAFREIQRMPPDLIILDRRLPDLDGLEVLMWVRKNYSNIPVLILTNAILESEVVAALEAGADDYVIKPPRKQEFVARVKALYRRATETRTLSELIEIGPYRIQTSEKVVYFHHEAITLSPKEYEIIELLARNIGQIVSRDKMVYQVWGRLPDEAAFRTLDTHIYRIRRKLELTRYNRLILRAVYMHGYRLEYMGVNNMMAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UK5</accession>
    <name>Q63UK5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521396.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108211.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35595">
        <property type="protein sequence ID" value="CAH35595"/>
        <property type="gene ID" value="BPSL1595"/>
    </dbReference>
    <dbReference type="GeneID" id="56529318"/>
    <dbReference type="KEGG" id="bps:BPSL1595"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3651"/>
    <dbReference type="eggNOG" id="ENOG50316Q1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWRNTDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266597" evidence="1">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="15090" checksum="F204D4AAF8CCA77E" modified="2004-10-25" version="1">MKLRTWLLLGTSSAVLAACGWFHAGPGERDIDAAVRRALDAENRGALNSMLGQPLPVAADVASVKPLGDCTKLAERTYSCNVAIAWHDARSGEGDGALRTTLTFTEDNDGAWQTSHVDAALAAGVAKSLIDRISGAVAASGASQAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US2</accession>
    <name>PURA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylosuccinate synthetase</fullName>
            <shortName evidence="1">AMPSase</shortName>
            <shortName evidence="1">AdSS</shortName>
            <ecNumber evidence="1">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purA</name>
        <name type="ordered locus">BPSL1524</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534924.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108144.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63US2"/>
    <dbReference type="SMR" id="Q63US2"/>
    <dbReference type="STRING" id="272560.BPSL1524"/>
    <dbReference type="EnsemblBacteria" id="CAH35525">
        <property type="protein sequence ID" value="CAH35525"/>
        <property type="gene ID" value="BPSL1524"/>
    </dbReference>
    <dbReference type="GeneID" id="56529248"/>
    <dbReference type="KEGG" id="bps:BPSL1524"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3562"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224262" description="Adenylosuccinate synthetase">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="317"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="431"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <sequence length="448" mass="48331" checksum="2061AA89D3911455" modified="2004-10-25" version="1">MSASAVNVTPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKTILRLIPSGIMREGVACYIGNGVVLSPEALFKEIGELEEAGLSVRERLFISEATTLILPYHVAIDQAREARRGAGKIGTTGRGIGPAYEDKVGRRALRVQDLFDARTFADRLRENLDFHNFVLTQYLGGAAVDFQATLDTMLGYADRLKPMVTDVSRRLYEENHAGRNLLFEGAQGTLLDIDHGTYPFVTSSNCVAGAAAAGAGVGPQKLDYILGITKAYCTRVGSGPFPSELYDADNPSRQDQIGITLANVGKEFGSVTGRPRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVKLCVGYKIDGEDVDLLPRGAAEVARCEPVYETFGGWKESTVGIDSWDALPANARAYLTRVQEVAGVPIDMVSTGPDRDETILLRHPFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UV3</accession>
    <name>Q63UV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527168.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108113.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1493"/>
    <dbReference type="EnsemblBacteria" id="CAH35494">
        <property type="protein sequence ID" value="CAH35494"/>
        <property type="gene ID" value="BPSL1493"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1493"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3528"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VTHKKWF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="518" mass="56605" checksum="9B61810BB18E6A96" modified="2004-10-25" version="1">MSAAPGRPPLWSAANLRGDFFPWVLAIVTGLDYFDNAAFSFFASYIAGGINASPDELVWASSAYAVTAVLGILQQQWWVDRLGHRRYVAGCMLMFSLGAMAAAAADTSLQLAFARGFQGYFIGPMMGACRILIQVSFAPKDRPPATRAFLIMLLLGSALAPIAGGLLVAHFTWRALFACTVPAGILFAALAFVALPDSGHTPPDERGGAHFWPYVIFALAQGALQIVMQQVRFQLFAGSPLLVLLAAGGLAALAWFGHHQWHHPAPLVRLHAFRERTFRVGLLLYLFYYYETTGYSYLISRFLETGLGYPVENAGRLVGTMSLISASALFVYLRYAKLLTHKKWIIVPGFALAAFAALWMTRMSPEVGEAALVAPLLMRGLLLLFIVLPVANLTFRVFAIDEYSHGYRLKNIVRQLTISFATASVIIVEQHRLAVHQTRLVEQANVYNPLFRQTLDTLTRGFAAAGHAFSDAHALALVTVSRTIAQQASFLASLDGFYFLAGVAICGGLFAAWQKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UX8</accession>
    <name>Q63UX8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phosphorous metabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoH family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108088.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1466"/>
    <dbReference type="EnsemblBacteria" id="CAH35468">
        <property type="protein sequence ID" value="CAH35468"/>
        <property type="gene ID" value="BPSL1466"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1466"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1647"/>
    <dbReference type="eggNOG" id="COG1875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMSPWAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="463" mass="51732" checksum="C6749E69717AC64D" modified="2004-10-25" version="1">MQKLFVLDTNVLMHDPSSLFRFEEHDVYLPMMTLEELDNHKKGMSEVARNARQVSRTLDSLVADAGPISAGIPLARLGSREALGRLYFQTTLTSIEPVEGLPQGKADNQILGVVRALQRERPDRQVVLVSKDINMRVKAHALGLPAEDYFNDQVLEDKDLLYSGVRELPQDFWTKHAKGMESWQDTKTGTTYYRVTGPLVASMLVNEFAYLEPQNGEPAFHAIVRELNGKTALLQTLRDYSHHKNNVWGITARNREQNFALNLLMNPEIDFVTLLGQAGTGKTLVALAAGLAQVLDDKRYNEIIVTRATVPVGEDIGFLPGTEEEKMQPWMGAFDDNLEVLQKTDDAAGEWGRAATQELIRSRLKVKSMNFMRGRTFVDKYVIIDEAQNLTPKQMKTLVTRAGPGTKIICLGNIAQIDTPYLTEGSSGLTYVVDRFKGWGHSGHVTLARGERSRLADYASDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V29</accession>
    <name>Q63V29_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative D-amino acid dehydrogenase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527209.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108037.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1415"/>
    <dbReference type="EnsemblBacteria" id="CAH35417">
        <property type="protein sequence ID" value="CAH35417"/>
        <property type="gene ID" value="BPSL1415"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1415"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3434"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QATHDWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="2"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="434" mass="45896" checksum="C509EDE8A8416D1F" modified="2004-10-25" version="1">MDVIVIGGGIAGIATAYQLRAAGHRVCVVERHATVAQGATYGQGGVLLPTPLDVWFGPTFMRERRAQKSGVVYKPGLNGALRRFTRRLDALREPAAFAAQYAQLRPLVELSREAIADVEARFNLEFEQKSGVLHVVRDAAEWDATQPALDLMRDLGQPYETLTPDACAALEPSMPVDPAFAGGVLLAQERTANCPLFAKLVKQVLDEHDVQFRLGRAVAAIRTDARRAAVELAPDAADPRAAKSKEVDVISADAVVVAAGTESLALVAPLGVRAPLHPVRIHTLTAPLAYEEHAPHLSIVDSAKRIAITRLGQRLRIGGGAVLQSAKDLARPLPEPLSEAALALLGQATHDWLPGTAKISAARAWQGAKLLSPDGLPVVGPTADPRVFVNFGHGPAGWGLAFGSAKVVADDLGGGAQRVPADTLAALRAERFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VG6</accession>
    <name>Q63VG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936953.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107900.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1279"/>
    <dbReference type="EnsemblBacteria" id="CAH35273">
        <property type="protein sequence ID" value="CAH35273"/>
        <property type="gene ID" value="BPSL1279"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1279"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.230"/>
    <dbReference type="eggNOG" id="ENOG50317EN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEYDREN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="59" mass="6211" checksum="664D026011D027E7" modified="2004-10-25" version="1">MNDPRSKKNPVFGVAMLIVVVIALVIGTILYNAISQKHEYDEAHPHAASAASAASAQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VK7</accession>
    <name>Q63VK7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutathione S-transferase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107859.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1238"/>
    <dbReference type="EnsemblBacteria" id="CAH35232">
        <property type="protein sequence ID" value="CAH35232"/>
        <property type="gene ID" value="BPSL1238"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1238"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1369"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SNYYNMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="224" mass="24864" checksum="3675779EE9313182" modified="2004-10-25" version="1">MMKETSMLRLCGFPVSNYYNKVKFVLLEHDIPFEASIVSVPIKDPAFLADTPLGKVPYLMTEHGSLCESQAIIEYLAAIHPDKPIFPADPFAAAKAREITAVLELYLEWNVRELFPEAFFGGKVSDGTKAHVEKRMPRALDGFKRLAKFSPYVLGDTFCIADIAAFIHLPVVALATKAIYGRDFVVDAGIDWKAYVKRIEEARPAAKRVSDERKAFVAGLAKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VN6</accession>
    <name>Q63VN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196428.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107830.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1208"/>
    <dbReference type="EnsemblBacteria" id="CAH35203">
        <property type="protein sequence ID" value="CAH35203"/>
        <property type="gene ID" value="BPSL1208"/>
    </dbReference>
    <dbReference type="GeneID" id="56595141"/>
    <dbReference type="KEGG" id="bps:BPSL1208"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.318"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VWSNVFM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="35492" checksum="55594DA7A491C8F6" modified="2004-10-25" version="1">MKAIEITEFGAPDVLKLTERPQPEPKRGEVLIKVAASGVNRPDVFQRKGAYAPPPGASDLPGLEVAGEIVGGDLADSAANPFGLKLGDRVCALLAGGGYAQYVAAPLAQCLPVPKGLTDVDAASLPETFFTVWSNVFDRAQLGAGEGGAQETFLVQGGSSGIGVTAIQIAHALGFRVFATAGTDDKCRACEALGAERAINYKSEDFVEVVKSLTHDRGVDVILDMVAGAYVPRELAALADGGRLVVIALLGGAKAEINVAEILRRRLTITGSTLRPRPVEFKAAIAAQLKARVWPLIEDGRVKPVIYRVLPAAQAADAHALMESSEHVGKIVLDWGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VP2</accession>
    <name>Q63VP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526456.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107824.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1202"/>
    <dbReference type="EnsemblBacteria" id="CAH35197">
        <property type="protein sequence ID" value="CAH35197"/>
        <property type="gene ID" value="BPSL1202"/>
    </dbReference>
    <dbReference type="GeneID" id="56526660"/>
    <dbReference type="KEGG" id="bps:BPSL1202"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.325"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="12"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="515" mass="53836" checksum="981C1DB60ED2EE9E" modified="2004-10-25" version="1">MKNLRASFSTFPRDFVAGTVVFLVALPLCLGIANASGVEPFAGLVSGIVGGLVVAVLSGSPLSVSGPAAGLVVIVVDGIAQLGSFQAFLLAVLLSGVIQFGFGLLKAGRFAAYVPSPVIKGMLAAIGILLIVKQVPFALGLSGDGDAPGHAVFASSAIALASLALLAVWETRAMRRFAFVRLVPAPLAVVILGIGATVLLGFVSPSFAPPAEHRVALPELASFAALGEALKTVDLGPNFAYLLSPDVWRIAITIAVVASLETLLSLEAVEQIDPKRRPSQPNRELKAQGVGNLVAGAIGGLPITSVIVRSSVNVNAGAQSRMSAIVHGVMLVVSVFALTWLLNLIPLASLAAILIHTGFKLAKPALFTSVAKQGPGAFLPFAVTIAGVLAIDLLAGIALGLACSVFAVACANLRSPATLAQHDDHYLLSFRKDVSFLGKVQIKQYLAQIPDRAVVIIDATRADYIDHDVREMIDAFVAEAPRREITVDYRRQVQHVRGAGLRWFFRNPAAQQAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VS4</accession>
    <name>Q63VS4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550719.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107792.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1170"/>
    <dbReference type="EnsemblBacteria" id="CAH35165">
        <property type="protein sequence ID" value="CAH35165"/>
        <property type="gene ID" value="BPSL1170"/>
    </dbReference>
    <dbReference type="GeneID" id="60546749"/>
    <dbReference type="GeneID" id="66546605"/>
    <dbReference type="KEGG" id="bps:BPSL1170"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.364"/>
    <dbReference type="eggNOG" id="ENOG50317DW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="30" mass="3495" checksum="25B2E43E20563812" modified="2004-10-25" version="1">MSWMLWLAGASTFLLFAYLVYALLRAEDIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VT5</accession>
    <name>NTPPA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="1">dTTPase/UTPase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL1159</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185695.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107781.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VT5"/>
    <dbReference type="SMR" id="Q63VT5"/>
    <dbReference type="STRING" id="272560.BPSL1159"/>
    <dbReference type="EnsemblBacteria" id="CAH35154">
        <property type="protein sequence ID" value="CAH35154"/>
        <property type="gene ID" value="BPSL1159"/>
    </dbReference>
    <dbReference type="GeneID" id="56595089"/>
    <dbReference type="KEGG" id="bps:BPSL1159"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.379"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000267267" description="dTTP/UTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <sequence length="209" mass="21984" checksum="CB9130C6FAFE84CA" modified="2004-10-25" version="1">MPEHAAPSYPFVYLASQSPRRRELLDQLGVRYELLAPAPDEDAEALEAELPGEAPDHYVLRVCVAKAQAARARLVARGLPAAPVLVADTTVTIDGAILGKPADAADALAMLARLAGRTHDVLTALAVIDATGELMPPALSRSAVRFAPAAREALARYVETGEPFGKAGAYAIQGRAAEFVERIDGSHSGIMGLPLFETAALLRAAHVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX2</accession>
    <name>Q63VX2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LPS core biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
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            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">K96243</strain>
        </source>
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    </dbReference>
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        <property type="protein sequence ID" value="CAH35116"/>
        <property type="gene ID" value="BPSL1123"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1123"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1240"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="394" mass="43151" checksum="44A808A138DA7622" modified="2004-10-25" version="1">MTAPLTLSRPPRTILVSCTRRLGDVLLTTPLVRSLKARWPDAQIDMIVFRGTEGVLEHNPDIRRVITVAPRARPKERIADALRIWRKYDLACAAISSDRARFYAFFAGRRRIGLVDPGRLTRLTRFILNGIVLDEHRDVHTVTSNLSLADALDVPRCADVVAPGIGDDPAARARFDAKLYGTPALSRGEPYIVLHPYPMFRYKQWHEDGWVDLVRWARSSGFAVALSGGPAQAERDYAARIARAAGEPVLNMTGELSFGESAEMFRHARLFIGPDTGATHVAAACGVPTIALFGPSNPTRWGPWPAHWPAGDEPWPLRGSGRRGNVYLLQGEGDCVPCKLEGCDRHLDSWSRCLSELPSARVIGVAAAMLGFDAANAPADVATPVDVSRLAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W41</accession>
    <name>Q63W41_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport, integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107675.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1048"/>
    <dbReference type="EnsemblBacteria" id="CAH35044">
        <property type="protein sequence ID" value="CAH35044"/>
        <property type="gene ID" value="BPSL1048"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1048"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1138"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LDIIWRM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="33"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="475" mass="48717" checksum="A14BEE087B2DF20E" modified="2004-10-25" version="1">MRAQRTRRPASRLATASAMNADSGLPFPQRYWAIVCVALGITLAVLDGAIANVALPTIARDLRASDAASIWIVNAYQLAVTISLLPLASLGDRIGYRRVYIAGLMLFTAASLGCALSGTLPALATLRVIQGFGAAGIMSVNTALVRMIYPSSQLGRGVAINAMVVALSSAVGPTVASAVLAVAPWPWLFAINVPIGVAAVCGSLRALPANPGRSAPYDFIGAVMNACVFGLLIVSVDGLGHGGNRASVALTALVAAVIGYFFVKRQLTQPAPLLPVDLMRVPIFALSIGTSVASFTSQMLAFVALPFWLQNTLGFSQVQTGLYMTPWPLVIVVAAPLAGVLSDRYSAGALGGIGLALFASGLFALATIGAHPTPVDIVWRMALCGAGFGLFQSPNNRAILSSAPRERAGGASGMLGTARLTGQTLGAALVALIFGIAPQHGPTIALYAASSFAAVAAAVSLLRIRARRDTTAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W70</accession>
    <name>Q63W70_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAH35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107646.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1018"/>
    <dbReference type="EnsemblBacteria" id="CAH35014">
        <property type="protein sequence ID" value="CAH35014"/>
        <property type="gene ID" value="BPSL1018"/>
    </dbReference>
    <dbReference type="GeneID" id="56526817"/>
    <dbReference type="KEGG" id="bps:BPSL1018"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.550"/>
    <dbReference type="eggNOG" id="COG2271">
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    </dbReference>
    <dbReference type="OMA" id="ICMTCMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
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    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="435" mass="46750" checksum="3BC3F16E63D5BDA8" modified="2004-10-25" version="1">MASTLPATTPDAPSAFEAATYRKVSWRLAPLLLLCYVVAYLDRVNVGFAKLQMAADLHLSDAVYGLGAGIFFIGYFLFEVPSNVILHKVGARVWIARIMVTWGIISALTMFVSTPAMFYTMRFLLGVAEAGFFPGVILYLTYWYPAHRRGRMTTLFMTAVALSGVVGGPISGYILKTFDGMNGWRGWQWLFLLEGVPSVLVGILLLFALDDGIAKAKWLDGDEKALLSRNVAAEEARKEDLPLSAVFASPRVWLMGFIYFSFVMGLYGVGFWLPTIIKSTGVTDAFAIGLLSAVPYAAAVVAMLAVARSADRRRERRWHLAIPAAAGALGLVLSVVWAHDTLLAMLGLTIATMGILTTLPLFWSLPTAFLGGTAAAAGIAIINSVGNLAGFLSPYLVGWLKQASASNAAGMYMLAGFLVLGGLLALTVPKSLVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W99</accession>
    <name>Q63W99_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193001.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107617.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0989"/>
    <dbReference type="EnsemblBacteria" id="CAH34985">
        <property type="protein sequence ID" value="CAH34985"/>
        <property type="gene ID" value="BPSL0989"/>
    </dbReference>
    <dbReference type="GeneID" id="56596201"/>
    <dbReference type="KEGG" id="bps:BPSL0989"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.585"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ADHIAKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="22589" checksum="D8D585D97F97AA83" modified="2004-10-25" version="1">MTVIVVANPKGGVGKSTLSTNLAGYFAAQGAWVALADLDRQQSAHAWLDLRPAGLPAIETWALDPDSPSKPPRGLEYAIVDTPAGLHGNRMNVALEFADKVIVPLQPSMFDILATQQFLERLASEKAVKKGAIKVGIVGMRVDARTRSADQLHRFVEGLDLPVLGYLRDTQNYVQLAAHGLTLWDVAKSRVDKDLEQWGPIVEWAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB6</accession>
    <name>Q63WB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192801.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107600.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0972"/>
    <dbReference type="EnsemblBacteria" id="CAH34968">
        <property type="protein sequence ID" value="CAH34968"/>
        <property type="gene ID" value="BPSL0972"/>
    </dbReference>
    <dbReference type="GeneID" id="56596219"/>
    <dbReference type="KEGG" id="bps:BPSL0972"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.602"/>
    <dbReference type="eggNOG" id="COG3471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPRYGKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267646" evidence="1">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="25633" checksum="14C440B0EDE717A8" modified="2004-10-25" version="1">MTKKSALAVAVTLAAALPIALALAPSAARAQSMGQMQPPAGVLSLSAQASTDVPQDVVDITLFYEQQAKDPGTLTAELNKRADTALAQARGVTGVTARTGEFSVSPSVDRDGKISAWRGRTEVVLESHDFAAASKLAGQLSPMMQVGNVSFSLSPEAQRAAEQKLTSEAIKAFRARAEEATRAFGYSNYSIREVNVGSGRNVQPYPRMFAMAAPAMDSAKMSAPIAVEGGKTTVTVNVNGSVQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WD4</accession>
    <name>Q63WD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107582.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0954"/>
    <dbReference type="EnsemblBacteria" id="CAH34950">
        <property type="protein sequence ID" value="CAH34950"/>
        <property type="gene ID" value="BPSL0954"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0954"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1035"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPCRAHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="112" mass="11873" checksum="AFC102910DA151EE" modified="2004-10-25" version="1">MTRAAGGPCRAHRSDGRRRAVDAPRPGARRQPRSRALRRSARHRAALEYAHGLVVPNGIVAPSAADRVGLDQRVGIMGVVKHGALVYSGPCPDGPRRAAVAAADACPHGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WR9</accession>
    <name>Q63WR9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="272560.BPSL0823"/>
    <dbReference type="EnsemblBacteria" id="CAH34814">
        <property type="protein sequence ID" value="CAH34814"/>
        <property type="gene ID" value="BPSL0823"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0823"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.779"/>
    <dbReference type="eggNOG" id="COG1121">
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7 10" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="30953" checksum="1B4101AF7B707ACD" modified="2004-10-25" version="1">MTHPMHALELDHVTLALGGRTILRDVSFAVESGEFVGVLGPNGAGKTTLMRAVLGLVPAHPGAIRVAGEPVARGNPAIGYMPQIRSALAGRRVRGRDFVAMAADGHRWGLPHASAAVAADVDRVLDLVGASALAKRPLSELSGGERQRLLLAQCLLGTPTLLLLDEPLISLDPNHQRGVVELVRRVQRELGITVLFSAHELNPLLNALDRVLYLGNGVAALGTVDEVITKPVLSRLYGSPIDVMRVNGRIFVMSGDVEVEKHDHGHEDEHDHGHEHGHAHSHGGGHSHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WW8</accession>
    <name>Q63WW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107398.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0773"/>
    <dbReference type="EnsemblBacteria" id="CAH34765">
        <property type="protein sequence ID" value="CAH34765"/>
        <property type="gene ID" value="BPSL0773"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0773"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.830"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWYPIVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="556" mass="59502" checksum="6525058AF804C6B1" modified="2004-10-25" version="1">METFMATVGGQIAHAPMTGDEKRVIFASSLGTVFEWYDFYLAGSLAAYISKSFFSGVNPTAAFIFTLLGFAAGFAVRPFGAIVFGRLGDLVGRKHTFLITIVIMGISTFVVGFLPGYASIGIAAPVIFIAMRLLQGLALGGEYGGAATYVAEHAPSHRRGFYTSWIQTTATLGLFLSLLVILGVRTAIGEEAFGSWGWRVPFVASILLLAVSVWIRLQLNESPVFLRIKAEGKTSKAPLTEAFGQWKNLKIVILALIGLTAGQAVVWYTGQFYALFFLTQTLKVDGASANILIALALLIGTPFFVFFGSLSDRIGRKPIILAGCLIAALTYFPLFKALTHFANPALEAATQKAPITVVANPDECSFQFNPVGTAKFTSSCDIAKSALAKSGLNYENVAAPAGTLAQIKIGDTAIATYDGKAADAKDQAKAFDKTLASTLKAAGYPAKADPARLNWPMTTVILAILVIYVTMVYGPIAAMLVEMFPTRIRYTSMSLPYHIGNGWFGGFLPATAFAIVAAKGDIYSGLWYPIGVALVTFVIGLLFVKETKDSNIYAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WY1</accession>
    <name>Q63WY1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107385.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0760"/>
    <dbReference type="EnsemblBacteria" id="CAH34752">
        <property type="protein sequence ID" value="CAH34752"/>
        <property type="gene ID" value="BPSL0760"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0760"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="85" mass="9979" checksum="5A40C53787822259" modified="2004-10-25" version="1">MVMRKKIRHAKSRVESKSGLKRVFDDALDQSLREYLDAVTPREYVELRTMPPFELGLMFKSALRDALYDRHHGERRRMAEGSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XB0</accession>
    <name>Q63XB0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189186.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107255.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0626"/>
    <dbReference type="EnsemblBacteria" id="CAH34619">
        <property type="protein sequence ID" value="CAH34619"/>
        <property type="gene ID" value="BPSL0626"/>
    </dbReference>
    <dbReference type="GeneID" id="56596681"/>
    <dbReference type="KEGG" id="bps:BPSL0626"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.998"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VKFEACT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="16027" checksum="7256D2D45A5BE887" modified="2004-10-25" version="1">MEEQDRIAILQQFGRTYRAFMSAFEAHVGQPLPRWRIMVALEQHGGASSQKRLVELLRVDPGALTRQLKTLETLGWIEREADARDNRVTNVKLTQAGRAAFEACLPRRNAFLHDTMASLPDDVLNALSGALSMLEARVAEAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XF4</accession>
    <name>Q63XF4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107211.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0583"/>
    <dbReference type="EnsemblBacteria" id="CAH34575">
        <property type="protein sequence ID" value="CAH34575"/>
        <property type="gene ID" value="BPSL0583"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0583"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLSELYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="444" mass="50658" checksum="FD7CAE20F77622E3" modified="2004-10-25" version="1">MFTAENFRRIYDAENRKGIDLATRYFPSLEPFTLAVRDKVQEIRDLRKVETTLTAEDFKAQLLALKAELVVLKEDKSSAIDILMGDISQKVLQPSFKIDLSQKTGPKGKPVFCIDADPETFFVIKQLQHNIHRIYSIKQANRHDLVCQLRDMLGSKFPFELVRTDISSFYESINRKHLVEKLDRDQLLSPASKKYIKQALDSYGTISGALIGIPRGVGISAYLAELYLRPVDKAIRAIPGLVLYCRFVDDIVAVFARPPIGKSLGSFKDRIIAIFGDSGLAHNSAKTSEFKLADTSTKKFEYLGYRFLLKPSQFKISPSAAKVTKYRARMDAAFEDYWRERPINPKGAFRKLVGRIKFLTGNTRLSNSKSCAVTGIYFNNSIVTDLSSFQLLDKRLKARIAELKRTSLQNQLKKLRFTTGFEERRYHNFSTKELQTIVRAWKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR4</accession>
    <name>Q63XR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative diaminobutyrate--2-oxoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195305.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107101.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0476"/>
    <dbReference type="EnsemblBacteria" id="CAH34465">
        <property type="protein sequence ID" value="CAH34465"/>
        <property type="gene ID" value="BPSL0476"/>
    </dbReference>
    <dbReference type="GeneID" id="56593841"/>
    <dbReference type="KEGG" id="bps:BPSL0476"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1179"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NLMPGVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="450" mass="47314" checksum="728A4C37B74CAA21" modified="2004-10-25" version="1">MQDVDPAYAFVRARESGARTYADTFDTVFAHGAGTVLTDTAGRRYLDFLSCAGTLATGHNHPAVVERVRAFVDSGQAMQMLDMTTPVKHRFVERLFGILPPALARHARVQFCGPSGADAIEAAIKLFKTATGRRSVIAFHGGYHGMTAGALALTGNLRAKHAVASLMPDVHVMPYPYAYRCPFGLGAPHTAAASLHYIESMLSDPESGIAKPACVIVEAVQGEGGVIPAPPEWLAGLRALTARLDIALVIDEVQTGIGRTGAMFAFEHSGIRPDAVVLSKAIGGGFPLALVAYDERYDVWEAGAHAGTFRGNQIAMAAGVACLDVIESEGLIAGAAAKEAHVRARLERLAARHPEIGDVRGRGLMWGIELVDPDAAPDAAGARPAAPALARALKRYCFAHGLIVETGGRHGAVVRLLPPLTVSAAELDLAFDTLDAGLAALGEHARAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XW7</accession>
    <name>Q63XW7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198290.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107048.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0423"/>
    <dbReference type="EnsemblBacteria" id="CAH34411">
        <property type="protein sequence ID" value="CAH34411"/>
        <property type="gene ID" value="BPSL0423"/>
    </dbReference>
    <dbReference type="GeneID" id="56594336"/>
    <dbReference type="KEGG" id="bps:BPSL0423"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1238"/>
    <dbReference type="eggNOG" id="COG3162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWANKSY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="10895" checksum="BCE5FF053A8898EC" modified="2004-10-25" version="1">METSVIETVVACRDYQQLVRARRRFSFTLTALMIATYYGFILLVALAPHTLAAPLYAGATISVGVVAGVAIIIVAIGLTAGYVLRANRSFDRAVDALFNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y02</accession>
    <name>Q63Y02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189087.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107013.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0387"/>
    <dbReference type="EnsemblBacteria" id="CAH34375">
        <property type="protein sequence ID" value="CAH34375"/>
        <property type="gene ID" value="BPSL0387"/>
    </dbReference>
    <dbReference type="GeneID" id="56594299"/>
    <dbReference type="KEGG" id="bps:BPSL0387"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1280"/>
    <dbReference type="eggNOG" id="ENOG50331FT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWQLNTP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021951">
        <property type="entry name" value="DUF3567"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12091">
        <property type="entry name" value="DUF3567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="85" mass="9750" checksum="05C8533968FC28E0" modified="2004-10-25" version="1">MQMIYNSPNYCVVEFPPQDGHHAMNSGGYEIVDKNAQREIFIDGELAARFREHVKQLIQAEPTLDEVDEFLGQFDSLMTQPVVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y59</accession>
    <name>Q63Y59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106956.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0329"/>
    <dbReference type="ESTHER" id="burps-q63y59">
        <property type="family name" value="Haloacetate_dehalogenase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34318">
        <property type="protein sequence ID" value="CAH34318"/>
        <property type="gene ID" value="BPSL0329"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0329"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.366"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPTLDMW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="316" mass="35375" checksum="B71EBF407F8943AB" modified="2004-10-25" version="1">MTRRSRSYNNETTIRENKTMSFEEFAPFRVTAQDVDIFGVKGGAGPPILLLHGHPQTHMIWHRVAATLARHFTVIATDLRGYGASGKPPSDARHAPYSKRAMAADQVAVMRHFGFPRFYVCAHDRGARVAHRMALDHPDAVERMLLLDIAPTLAMYERTDRAFATAYFHWFFLIQPEPLPETLIGGQSDAYVEAVMGNRSAGLAPFSPEALHAYREALRQPGAVHAMCEDYRASATIDLDHDRADLERGHKLACPLRVLWGEQGVVARCFEPLDEWRRVARDVSGRALACGHYIPEEAPVALIDEIVSFFEAREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YB0</accession>
    <name>Q63YB0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidoglycan hydrolase FlgJ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Muramidase FlgJ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the glycosyl hydrolase 73 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FlgJ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197262.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106905.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0278"/>
    <dbReference type="EnsemblBacteria" id="CAH34266">
        <property type="protein sequence ID" value="CAH34266"/>
        <property type="gene ID" value="BPSL0278"/>
    </dbReference>
    <dbReference type="GeneID" id="56594371"/>
    <dbReference type="KEGG" id="bps:BPSL0278"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1427"/>
    <dbReference type="eggNOG" id="COG1705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGVFVQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019301">
        <property type="entry name" value="Flagellar_prot_FlgJ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013377">
        <property type="entry name" value="FlaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10135">
        <property type="entry name" value="Rod-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02541">
        <property type="entry name" value="flagell_FlgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYZ2" evidence="9">
        <location>
            <begin position="155"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="32719" checksum="265E5F27968423AF" modified="2004-10-25" version="1">MTTFTKPNDLSQRFALDVQGFDALRSKATAAAPREGVKMVAGQFDAMFTQMMLKSMRDATPSDGLLDSSSSKMYTSMLDQQLAQQMSSKGIGVADALTKQLLRNANVAPDAQGEGGLAAMNALAKAYANSNGAPGNGALAGTRGYSAASALTPPLKGNGNSAQADAFVEKMALAAQAASATTGIPARFIVGQAALESGWGKREIRGANGESSYNVFGIKATKGWTGRTVSAVTTEYVNGKPHRVVAQFRAYDSYEHAMTDYANLLKNNPRYASVLNAGHNAEGFAHGMQKAGYATDPHYAKKLISIMQQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR1</accession>
    <name>Q63YR1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523096.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106754.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0127"/>
    <dbReference type="EnsemblBacteria" id="CAH34113">
        <property type="protein sequence ID" value="CAH34113"/>
        <property type="gene ID" value="BPSL0127"/>
    </dbReference>
    <dbReference type="GeneID" id="56527586"/>
    <dbReference type="KEGG" id="bps:BPSL0127"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1595"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SKFARMP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017232">
        <property type="entry name" value="NtrY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037532">
        <property type="entry name" value="STHK_NtrY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="335"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="547"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="802" mass="86875" checksum="50B95DB20AAF5A63" modified="2004-10-25" version="1">MRVRRATSGKSLLIRVIVSTVAITALLLLVLLAAASANTEFFDRYYSWLYSANIIVALVFMLVVLGLVGMIVARLRKGKFGTRLLAKLAVFFTLVGVVPGGIIYIVSYQFVSRSIESWFDVNVETALTAGLNLGRGMLDTSLADLQTKARLMSEQLSSADANTNGTTLTLLRLRDQFGVQDATIVEPGRGTGASPDVHIIAQASGNFAALIPDDMPTPLMLSQAREHGVFAAIEGEVDGDPRARGSKGALRLRVVQRIPDSSTSLLQPAERFLQLTQPVSPTLARNADAVQRAYREYQEKSLGRSGLRKMYIGTLTLALFLATFIAMMIALALGNQLARPLFLLAQGTKEVAEGDYTPKREIKTRDELGFLTQSFNAMTRQLSEARLAVEKNRVALEHSKTYLESILANLTAGVFVLDRQFRLTTANRGAERIFRQPFNSLIGTTLDQIGVVAEFGAMVRKAFADREAAGRGGGEDRGHWQQQFAVEVPGETEPLTLLVRGTRLVSTAAAPGQPDDPQTSGYVVVFDDISDVISAQRSVAWGEVARRLAHEIKNPLTPIQLSAERLQMKLSDKLSQPDADVLKRGATTIVNQVAAMKRMVDDFRDYARTPPAVLVNLQLNDLVSEVLTLYGVGEGKSTIVVEQTPLPVIRGDATQLRQVIHNLLQNAQDSVADVEHPRVLLETKTVEYGDPDANGKTRVAVRLTVSDNGPGFPARILTRAFEPYVTTKAKGTGLGLATVKKIVDEHGARIDLRNRMHGDVVEGAQVSILFLQLADDTAGAGGGTNGGTAPAKTRATVQTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YZ7</accession>
    <name>Q63YZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III restriction system endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204734.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106668.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0043"/>
    <dbReference type="REBASE" id="10393">
        <property type="entry name" value="BpsKORF42P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34026">
        <property type="protein sequence ID" value="CAH34026"/>
        <property type="gene ID" value="BPSL0043"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0043"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1701"/>
    <dbReference type="eggNOG" id="COG3587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMQVDSE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015668">
        <property type="term" value="F:type III site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045572">
        <property type="entry name" value="RE_endonuc_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19778">
        <property type="entry name" value="RE_endonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="85"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112537" checksum="B031BAFB34039E32" modified="2004-10-25" version="1">MQLHFESDLDYQLEAIEAVCDLFRGQEACRAEFSVTAQAARRRAGPQISLGMAESGLGVGNRLTLDAHTFAENLARVQVRNGLPPSGAPSSNDFTVEMETGTGKTYVYLRTIFELHRRFDFTKFVIVVPSVAIKEGVHKTLQITEQHFRRLYAGVPFDYFVYDSAKLGEVRSFASKSIVQIMIVTVAAINKKDVNTLYKDSEHTGGEKPIDLIRATHPIVIVDEPQSVDGGLEGRGKEALEAMRPLCTLRYSATHADKYQMLYRLDAIDAYERKLVKQIEIASATVEDAHNKPFVRVISIGSRRGAIAARVELDVATAAGDVERQTVSVSDGDDLERVARRAVYANFSIGEIHAARGAEYLVLRYPGGDAFLSVGDAYGDVDTHAIQREMIRRTIREHLDKELRLTPLGVKVLSLFFVDAVDKYRKYDRHGQPFKGDYALLFEDEYRRAAKLPEYRALFDGVDAGLAAEAVHDGYFSIDKKGGWTDTSDRSAGSRENAERAYGLIMKDKERLLSFDTPLKFIFSHSALKEGWDNPNVFQICTLRDIHSERERRQTIGRGLRLAVNQRGERVRGFDVNTLTVIAGESYEQFAENLQKEIEADTGIRFGIVETHQFAALPVPADDGSVQPLGVERSAALWMHLRDAGYLDARGRVQDTLRAALKLRALPLPDEFDALRALIVDMLRKLAGRLDVRNADERRHIALRRDAHGKAVYLGDAFRALWDRIRHRTTYRVNFDNARLIERCVAALKAAPAVTRARLQWRKADIAIDASGVEATETEDAGAIAIDEGEVELPDLLTELQDRTQLTRRTIAKVLIESGRLDEFPLNPQRFIALVAAALERCKRDALVDGIEYRLLGEAQVHALSLFESEPLTGYLSSMRRGAAKSIHEDVPCDTPAERAFVESLEQDDAVRLYAKLPGWFKIPTPLGSYSPDWAVLIAEGDGPRLYFVVESKSGVADGDLRADERRRVQCGAAHFRALEAVADNPARYVRARRADDLPTAAANARDAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>P0DMK9</accession>
    <accession>Q63QL3</accession>
    <accession>Q9ZF70</accession>
    <name>LEP4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>Prepilin leader peptidase/N-methyltransferase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>Leader peptidase</fullName>
                <ecNumber evidence="1">3.4.23.43</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Prepilin peptidase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>N-methyltransferase</fullName>
                <ecNumber evidence="1">2.1.1.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name type="primary">gspO</name>
        <name type="ordered locus">BPSL3010</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Zinc is required for the N-terminal methylation of the mature pilin, but not for signal peptide cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.43" evidence="1"/>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109605.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0DMK9"/>
    <dbReference type="STRING" id="272560.BPSL3010"/>
    <dbReference type="MEROPS" id="A24.A10"/>
    <dbReference type="EnsemblBacteria" id="CAH37021">
        <property type="protein sequence ID" value="CAH37021"/>
        <property type="gene ID" value="BPSL3010"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3010"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3439"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000192618" description="Prepilin leader peptidase/N-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P22610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="32194" checksum="AA504AA7425B5DBB" modified="2014-07-09" version="1">MPTASMTPNPFLSGSPEHAAAAGPLAAFAALPTGMQLAFAIVLGLVVGSFINVVVHRLPIMMKRAWLAEIAEATGAPCADDGLPARYNLCVPRSACPHCGHALRAWENVPVLSYIALRGRCRHCRTPIGARYPLIELASGALAAGALALFGPSGAALAAFGLCAALLAMSAIDMQTGFLPDSLTLPLLWAGLCVNLWGTFASLRAAVIGAIAGYLFLWCILWLFKLLRGIEGIGYGDLKLLAALGAWLGWEALPQVVLIAAVAGAAVGLVATWRGRMRFEEPLPFGPFLAAGGAATLFFGTPFYLLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HU1</accession>
    <name>Q63HU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112331.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2329"/>
    <dbReference type="EnsemblBacteria" id="CAH39815">
        <property type="protein sequence ID" value="CAH39815"/>
        <property type="gene ID" value="BPSS2329"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2329"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6787"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFDLATY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="456"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="544" mass="57218" checksum="92A112036FEC6222" modified="2004-10-25" version="1">MVGKGNLMAQVAFLFPGQGAFYAGATRALSGAYPVVQRAMQAIDAVSVRRLRRPLLATVWDGHIGAEDLLQHAPDLLQLAIYATSVSYFEALRARGVRPDVLVGHSFGEIAALTCAGAFSIETGAEIVCDRIDALRAAAPADGRMAAVGASPDAVRAHLAACFRDARAGRVRIAVENHVSQTVVSGACEYVDEFRAYCARNNISAQVLNSPYAFHHEDLENARIEFGRRLKAYKNKALEYPVYSPILNRYYTAADDLGACLARHLVLPVRFGDGVARLKAAGIGAFVECGALNALSRISVRALGPGAVKTFPGASSAGGELAGLENVLAYFNGGSVMNDDIRASNLQLDFDEFWRNSGPGIVDKIKGELKRFFDARGLQATPAPQIVADHGVAAGFAGGLTAGAADYAPKVAAGVSSAAAPVAAPIVAAAPAAPLAVAPAAPVAQAAAVPAASARVPRDRLFVELVAIYAEAMEYPVEVFTETVELEAELGIDSVKQTEIIQRISARYGLPPLPANFRAGDFKAMGQIVDFVYEHQGEAALVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ4</accession>
    <name>Q63HZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200700.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112278.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2275"/>
    <dbReference type="EnsemblBacteria" id="CAH39761">
        <property type="protein sequence ID" value="CAH39761"/>
        <property type="gene ID" value="BPSS2275"/>
    </dbReference>
    <dbReference type="GeneID" id="56598385"/>
    <dbReference type="KEGG" id="bps:BPSS2275"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5889"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIRQMRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="42245" checksum="A89C9F224016B56D" modified="2004-10-25" version="1">MTQDVTVFRARYRASVHPRYNAWLHGGFVLAYGCAAIAFFLKDVARVSAVQWASVPAAFLLFNWLEFTVHRHVGHVKRRFGAMFYRRHTGDHHSFFANEQIAYREARDWRVILFPAWLIVVFSLGLFALHAVLGRFDANVAGLFASTMLGGYLLYECVHACEHLPDAHPLAKWPWIRQMRVLHRVHHRDALMRSCNFDVIWPLMDWLHGTLRWSEAPGADMSTRMRHEIDIACAGADVLAYASDASRWPEWHPSSLRVDGPAGSLAAGSRFDEDVRAAGRVDRLHWDVVRNEPGVMWQARAANTAGSLRILLTYECSGGPRGARFVRTLHYHSPNPLLRLANALVMRGRVERESAYSLTLLKRRLEAARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I27</accession>
    <name>Q63I27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112245.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63I27"/>
    <dbReference type="STRING" id="272560.BPSS2242"/>
    <dbReference type="EnsemblBacteria" id="CAH39728">
        <property type="protein sequence ID" value="CAH39728"/>
        <property type="gene ID" value="BPSS2242"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2242"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5843"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPLDQQV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="271" mass="28897" checksum="CB5F3590A7B081EA" modified="2004-10-25" version="1">MKCTLKPIGEQTIVITGATSGIGLVTARKAAKKGAKLVLVARNDTALEALCEEIRQHGGLAVAVAADVSRYEDVQRAAAKAVETFGGFDTWINNAGVTIFGSALSVPLDDQRRLFDTNYWGVVHGSLVASEHFRRQSDFRGGAIINMGSEASDAPVPLQSAYAASKHAIKGFTDSLRIELEADNVPVSVTLVKPAAVDTMFVMHAKNYMNVEAKLPPPIYDPDIVADAILFAAEHARRTLFVGGAAKLASSGAYHAPRLFDRLATSLFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I31</accession>
    <name>Q63I31_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188544.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112241.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2238"/>
    <dbReference type="EnsemblBacteria" id="CAH39724">
        <property type="protein sequence ID" value="CAH39724"/>
        <property type="gene ID" value="BPSS2238"/>
    </dbReference>
    <dbReference type="GeneID" id="56598345"/>
    <dbReference type="KEGG" id="bps:BPSS2238"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5836"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="30245" checksum="FFCDAA3FC4E4CC12" modified="2004-10-25" version="1">MSTAEASSPQGRTPQPGREREMAAKPRDEAAGYVGSGRLDGKVALVTGGDSGIGRAVAVGFAKEGADVAIVYLNESDDAAHTKHLIEQTGRRCETIALDIGERANAHVALRRAVERFGRLDVLVNNAGEQHVQTDIGQISEAQLTHTFRTNIFAMFFCTQAALTHMKAGARIVNTASVTAYHGNPVLIDYSATKGAIVSFTRSLALNLASRGIHVNAVAPGPIWTPLIQSTFDDEQRARFGANVPLKRPGQPDELIGCYVLLASDGADYMTGQTLHPNGGTIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I51</accession>
    <name>Q63I51_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541992.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112221.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2219"/>
    <dbReference type="EnsemblBacteria" id="CAH39704">
        <property type="protein sequence ID" value="CAH39704"/>
        <property type="gene ID" value="BPSS2219"/>
    </dbReference>
    <dbReference type="GeneID" id="56531692"/>
    <dbReference type="KEGG" id="bps:BPSS2219"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5808"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYTTIAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266891" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4397" evidence="2">
        <location>
            <begin position="37"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="252" mass="25666" checksum="E8A53E7AF322B497" modified="2004-10-25" version="1">MKPIRTVAALISAVALVAACGGDDTGTELGISNPQARFINAVPAGPSLDYYLNAQANATGIAYKGVTRYRSVGSGSQTASYDVTGTSVTIASQTFNAANGHHYTTIAIPSTSTPISVIDDPFAKGLLSDQARVRGFNASPNAQNVDIYVVPPGTNIAAQSPTLAGAAYQNAVPASGQDSIYLSGGTYQVIVTLPGSKTPILTTPPVSIANNADWLLLTIPAGGVADVVPNDIHVLVAQGNDADTSAQELGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I94</accession>
    <name>Q63I94_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microcystinase C</fullName>
            <shortName evidence="1">MlrC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M81 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112178.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2176"/>
    <dbReference type="EnsemblBacteria" id="CAH39661">
        <property type="protein sequence ID" value="CAH39661"/>
        <property type="gene ID" value="BPSS2176"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2176"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5756"/>
    <dbReference type="eggNOG" id="COG5476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAAPGAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009197">
        <property type="entry name" value="MlrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012702">
        <property type="entry name" value="UCP012702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1485" evidence="3">
        <location>
            <begin position="3"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="MlrC_C" evidence="2">
        <location>
            <begin position="303"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="502" mass="53421" checksum="D7E458CDD3600836" modified="2004-10-25" version="1">MNILIAGFQHETNTFAPTRASYQSFVRGEGFPPLARGAGVLSLRDVNVPIGGFIRAAQASGHALLPVVWAGACPSAHVTSGAFERIGGEIVAAVQAGGFDAIYLDLHGAMVTEQFDDGEGELLARVRRIVGERMPIVVSLDLHANVTARMAAHASALVAYRTYPHVDMAQTGERAARVLERLAAEARPLHCAIRRLPFLIPINGMCTHAEPASGAYRLLAQLERDGVVSMSFAPGFPAADFPECGPTVWAHAFEADAAQRAADALFAKLVGDEARWSVPLLAPDAAAAEAIRLSRTATRPIVIADTQDNPGAGGDADTMGMVRALLRCDARDAAVGVIWDPDAAAAAHRAGVGARIGLRLGGRSRVRGDAPLDAEFEVEHLSDGRFRFDGPMFNGAHGELGPVACLRIDGVRIAVSTNKMQTFERNQFRVAGIEPERTKIVVNKSSVHFRADFEAIADAILVAKSPGPMAADPADLAWARLDPDIRVRPNGPTLRSLRAMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IH8</accession>
    <name>Q63IH8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540225.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112094.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2095"/>
    <dbReference type="EnsemblBacteria" id="CAH39575">
        <property type="protein sequence ID" value="CAH39575"/>
        <property type="gene ID" value="BPSS2095"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2095"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5638"/>
    <dbReference type="eggNOG" id="COG3520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WADAQST"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03347">
        <property type="entry name" value="VI_chp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="492" mass="53073" checksum="30DF0658015C2E7C" modified="2004-10-25" version="1">MTTNPKPEPAGVDAGSHANSNAGRRAGAAANAEANAEPDAMPNALRGAAADVAPSAAPSATPNATPSATSQAAAARRDAWWRRLRAAPHGYDLFHALRWLDALSPEHAPSGYASRPRDEPVRFGQAPSLAFAAAMLADVRDDGPRPRVAIHGFGLFGPNGPLPSHLTEYAYERATQHDDPTFAAFADLFHHRLILLFYRAWADAQPTVSLDRPARARFDRYVASLIGPCDALLADSPRGSRPDSSFASSSDSLPDSPPDSSPDSPPDSRSDSPSDARLDPHPDSPRGAGALAPHAKYHQAGHLVRHTRNPEGLVQILRRYFGVRVRIVEHVPHWVMLDRAQRCAIRATRPTQPLGGAVLGRAVRDAQSRFRIVLGPLTLDEYRRFLPGGVHARQLAQWVREYVGIEFDWDVQLELARGEVPTLALGSRHGLGRTAWLGERLDPGPARDLVLGYDERMRASRARSGAADQAAAAGALIANLPEREPPCPISAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IV2</accession>
    <name>Q63IV2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205713.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111970.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1964"/>
    <dbReference type="EnsemblBacteria" id="CAH39442">
        <property type="protein sequence ID" value="CAH39442"/>
        <property type="gene ID" value="BPSS1964"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1964"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5460"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AERYWRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="181"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="417" mass="43308" checksum="55FA08032846A453" modified="2004-10-25" version="1">MKQPAPAECDAPPPVAPFHDGELAAQRRAGVAAAAAAFGGRGIRTFMPDQHRAFFAQLPLLVVGGVDGGGQPWATLRAGAPGFVSAPQPRTLDIAGGTLRGDPLEGNWRIGSLLGGLGIELHTRRRNRVNGVVASIAGDAMSVTVEQSFGNCAKYIQGRTPTPVPPQAGGAPPQRRVARLDAADRALLARADTFFIATANTSDAAGGARGVDVSHRGGPPGFVRVDDDGTLTTPDYSGNNFFNTIGNLLHDPRAGLLFVDFERGDLLYIAADAQIVWDGPALAAFDGARRLVRLRIREVRRSAAVLPFRWSAPRFAPQFAAWGDAGARSLASRAESAAVGGSATAIVSVTQAASAGRGESAEWPESSVSLKVLKASEASEASEASEASETPETPETPETPETPETPETPGVAGACVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J19</accession>
    <name>Q63J19_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol oxidase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cyoA</name>
        <name evidence="15" type="ordered locus">BPSS1897</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205698.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111903.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1897"/>
    <dbReference type="EnsemblBacteria" id="CAH39375">
        <property type="protein sequence ID" value="CAH39375"/>
        <property type="gene ID" value="BPSS1897"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1897"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5363"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TAMNSFF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009486">
        <property type="term" value="F:cytochrome bo3 ubiquinol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04212">
        <property type="entry name" value="CuRO_UO_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010514">
        <property type="entry name" value="COX_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034227">
        <property type="entry name" value="CuRO_UO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006333">
        <property type="entry name" value="Cyt_o_ubiquinol_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06481">
        <property type="entry name" value="COX_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000292">
        <property type="entry name" value="Ubi_od_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01433">
        <property type="entry name" value="CyoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="14">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="13">
        <location>
            <begin position="123"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH39375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="32595" checksum="A12DA4D5AE009042" modified="2004-10-25" version="1">MNRKAFRSLSWFGAIGALASLSSCGLDVLDPKGAVGAAEKSLIATSTWAMLIVVVPVILLTLLFAWRYRASNRNATYAPKWAHSTAIEIVIWTVPSLIILFLGILTWKTTHALDPYRPLESSVKPIDVEVVALDWKWLFVYPDLGIASVNQLAVPVGTPINFRITSDSVMNSFFIPQLGTQVYAMAGMQTRLHLIADEPGDFAGISANYSGRGFSDMKFRTLATSRDAFDAWVAKVRASADRLDMTAYGQLAQPSEKQPVRYYSTVDPRLFNNIIAKYNNGHVLDLTDAACRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J76</accession>
    <name>Q63J76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533201.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111846.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1842"/>
    <dbReference type="EnsemblBacteria" id="CAH39318">
        <property type="protein sequence ID" value="CAH39318"/>
        <property type="gene ID" value="BPSS1842"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1842"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5291"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHITRSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="179" mass="19222" checksum="C9D34E9D7A286DA0" modified="2004-10-25" version="1">MVQIVVIAGAAALAFALPLMLYAASRPGTRRVEHRARIEAGAARIFPAPADLRRFDACNPCERKAPALRGAYGAVRSGVGAGDAWTREKAGVGRFGTTGLGEPSHVRTRLDFVRRFDAHDVAEFALRPDGDATVVTWAMRGPSPFLSKLMRACLSIGKMVGKDFYTRLANPKALAEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J93</accession>
    <name>Q63J93_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544567.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111829.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1825"/>
    <dbReference type="EnsemblBacteria" id="CAH39301">
        <property type="protein sequence ID" value="CAH39301"/>
        <property type="gene ID" value="BPSS1825"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1825"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5272"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NFHGPWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="41730" checksum="9084969BC26A525E" modified="2004-10-25" version="1">MKHTETSIKSLQIGMHWFPERAGGLDRMYYSLVGALPSAGVAVRGVVAGSERVAADTGGAIRGFGPATSSLPRRMIAARHALRDVMRIERPDVVSSHFALYTFPGLDVTRGIPQVSHFQGPWADESHVEGADSLGQKVKHRLEQAVYARSSRLIVLSHAFGQILTSRYNVDPARVRVVPGCVDTAQFDLPMTPADARRKLQLPQDRPIVLAVRRLVRRMGLEDLIDAVKTVRRRHPDVLLLIAGKGRLEGELRKRIDDAELGENVKLLGFVPDNHLAALYRAATLSVVPTVALEGFGLITVESLASGTPVLVTPVGGLPEAVAGLSEALVLPEVGAAAIADGLAAALSGSLVLPDADACRRYARAHFDNTVIARRVAEVYEEAIRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP4</accession>
    <name>Q63JP4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187562.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111678.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1673"/>
    <dbReference type="EnsemblBacteria" id="CAH39146">
        <property type="protein sequence ID" value="CAH39146"/>
        <property type="gene ID" value="BPSS1673"/>
    </dbReference>
    <dbReference type="GeneID" id="56598025"/>
    <dbReference type="KEGG" id="bps:BPSS1673"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5075"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRFCYAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="333" mass="35238" checksum="F6F0B1FAEB79820C" modified="2004-10-25" version="1">MSYSLSLLDKSPIAEGATAADALRFTVALAQRAEALGYRRFWIAEHHGAPGLASSAPEIVVSHVLAHTSSIRVGSGGVMLQHYSPFKVAETFKLLASLAPGRVDLGVGKAPGGLPLTTRALQSLHDKPRRPAFAEQLAELDAFLNWGVAEDHPLAGALALPVPPEAPERVLLGGSPESAALAARLGWQFCYAGHFNGDEANVERSLDAYRSATGRAPLLALYAVAAPTKGDAERLIGALRIFKLKLASGQSVNLGSAQAAAEFARQSGATDYRIDELRPHVIAGAPDDVHRELDALSRRYGLAEFVVDSPVTHYPARLASVELLAPQRQPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JZ9</accession>
    <name>Q63JZ9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525296.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111573.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1567"/>
    <dbReference type="EnsemblBacteria" id="CAH39040">
        <property type="protein sequence ID" value="CAH39040"/>
        <property type="gene ID" value="BPSS1567"/>
    </dbReference>
    <dbReference type="GeneID" id="56530023"/>
    <dbReference type="KEGG" id="bps:BPSS1567"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4933"/>
    <dbReference type="eggNOG" id="COG3826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MARHRFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018655">
        <property type="entry name" value="DUF2086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09859">
        <property type="entry name" value="Oxygenase-NA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="146"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="29113" checksum="242600AA766DAC78" modified="2004-10-25" version="1">MNTLSEPRVPAARAHDETASGAAREAALARRIDALPWASIERDLERDGHAIVHGLLAPRTCEALAALYARDALFRSRVTMARHGFGRGEYQYFGYPLPRAVHALRTALYPHLAPIANRWHAQMRIDARFPAEHAHFIERCRAAGQLRPTPLLLRYREGDYNCLHQDLYGEHVFPLQAAVLLSKPGADFAGGEFVITEQRPRMQSRADVVPLEQGDAVVFAVHHRPVQGARGVYRVNLRHGVSRVRSGQRHTLGIIFHDAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K83</accession>
    <name>NADE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="1">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadE</name>
        <name type="ordered locus">BPSS1482</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525360.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111489.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63K83"/>
    <dbReference type="SMR" id="Q63K83"/>
    <dbReference type="STRING" id="272560.BPSS1482"/>
    <dbReference type="EnsemblBacteria" id="CAH38955">
        <property type="protein sequence ID" value="CAH38955"/>
        <property type="gene ID" value="BPSS1482"/>
    </dbReference>
    <dbReference type="GeneID" id="56530104"/>
    <dbReference type="KEGG" id="bps:BPSS1482"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4824"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVVQYAL"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000099013" description="NH(3)-dependent NAD(+) synthetase">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <sequence length="284" mass="30882" checksum="8AF21BEE0B0BCEAF" modified="2004-10-25" version="1">MSRPDQAARRRAIAAELHVSPTFDARDEAERRIGFVADYLRTAGLRACVLGISGGIDSSTAGRLAQLAVERLRASGYDARFVAMRLPYGAQHDEADARRALAFVRADETLTVDVKPAADAMLAALAAGGLAYLDHAQQDFVLGNIKARERMIAQYAVAGARNGVVIGTDHAAESVMGFFTKFGDGGADVLPLAGLTKRRVRALARMLGADEPLVLKTPTADLETLRPQRPDEHAYGITYEQIDDFLEGKPMDDAVAETVLRFYDATRHKRALPYTMFDWPGHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE5</accession>
    <name>Q63KE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dehydrogenase/oxidoreductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528721.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111427.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1415"/>
    <dbReference type="EnsemblBacteria" id="CAH38890">
        <property type="protein sequence ID" value="CAH38890"/>
        <property type="gene ID" value="BPSS1415"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1415"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4739"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMFMQAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="167"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="29959" checksum="17A794BA8499B830" modified="2004-10-25" version="1">MSRNVGVIGLGAMGLGVARSLLRAGFRVHACDVREDVLAAFAAEGGVRCATPAELGALCGVVVTLVVNAQQTDAVLFGEQGAAAAMPRGGVVISSATVAPDFAAQLGARLAAAGLLMLDAPVSGGAARAASGEMTMMTSGPAAAYEACGDVLAAIAGKVYRLGDAHGAGSKVKIINQLLAGVHIAAAAEAMALGLREGVDPDALYDVITHSAGNSWMFENRVPHILNGDYTPLSAVDIFVKDLGLVLDTARRSQFPLPLSATAHQMFMSASSAGHGGEDDSAVIKTFPGIALPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM1</accession>
    <name>Q63KM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transmembrane cytochrome b561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528645.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111350.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38811">
        <property type="protein sequence ID" value="CAH38811"/>
        <property type="gene ID" value="BPSS1340"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1340"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4641"/>
    <dbReference type="eggNOG" id="COG3038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GLIAWHL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="177" mass="19051" checksum="CA078E098DEEDF15" modified="2004-10-25" version="1">MTPSTRTPDRYDLLSRILHWSVAALVLAQFALGWTMPDVHGTAPPVGLVAWHVALGTALIVVIAARLLWSIVRRSPPAHQQGALLSFAASATHKLLYVALIAVPLLGWLNANGRTWQLKLTGAIPLPTIAAPHSLGAAIGEWHSLSATLFIVLIGMHALAALVHRFVMKDGAFERMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L21</accession>
    <name>Q63L21_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528473.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111200.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1190"/>
    <dbReference type="EnsemblBacteria" id="CAH38657">
        <property type="protein sequence ID" value="CAH38657"/>
        <property type="gene ID" value="BPSS1190"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1190"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4425"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HESHFCW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="33851" checksum="4A9586B4827A5126" modified="2004-10-25" version="1">MTKSTIVRSRPAQSVLDFGIVAPGRAGPAVLADSLELAGRLDRLGYHRLWLSEHHESHFCWAVPEVMVAALAQRTRALRIGTAAVLLPVRNPLLLAESFRVLEALTPGRIDLGVCAAVPLDPVALAALAEQPGPDVAALMASFDGRLGVLLDYLRGRFPDGHRFACGATPPFVDAPPVWVMGSGPGSAATAAARGAHYAYSLFHKGSRQDPAVPAAYRERRPDGRVALAVSCISADTAAAAAAQRRLVEGWLRDDMRVVLSGTHHDCREQVLALAQRFRADEVILLHLWHDPARRVDAIEAMASLIHPLAEPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LA3</accession>
    <name>Q63LA3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528317.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111118.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1105"/>
    <dbReference type="EnsemblBacteria" id="CAH38573">
        <property type="protein sequence ID" value="CAH38573"/>
        <property type="gene ID" value="BPSS1105"/>
    </dbReference>
    <dbReference type="GeneID" id="56530481"/>
    <dbReference type="KEGG" id="bps:BPSS1105"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4315"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CYVFINN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="246" mass="26467" checksum="D36F677AB807E1CC" modified="2004-10-25" version="1">MKTDWTEHEVSQRFHAYDDRIEARFGYQPLIAELTGSHGTAIRVLDYGCGGGKVARRLRAAGVARVTGVDIAPTMIEQAIAAGVDDGLDYVHIDGPSLPFDDASFDAAISCFLFVNIAERAALARVAAEVRRVLKPGGAYYVLDTNPRTTGVQYPTFRNGEPGIVYRDGDARPVHLNVPGEGVFDVVDTHWEIPTYRHAFETAGLALAAVMELGFRAADAGGAPGAHADADGSKPFVLFKATRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LQ5</accession>
    <name>Q63LQ5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202650.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110966.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0958"/>
    <dbReference type="EnsemblBacteria" id="CAH38420">
        <property type="protein sequence ID" value="CAH38420"/>
        <property type="gene ID" value="BPSS0958"/>
    </dbReference>
    <dbReference type="GeneID" id="56597323"/>
    <dbReference type="KEGG" id="bps:BPSS0958"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7272"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IMHAERN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010609">
        <property type="entry name" value="Gp5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06715">
        <property type="entry name" value="Gp5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="2">
        <location>
            <begin position="401"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="661" mass="72375" checksum="7E0EFE5BE8E8AADD" modified="2004-10-25" version="1">MKMSDIAGFLSLQNSRLLTIKTPLAGRSELVLSEFQCSEGLSVLFDMRLGLVSRDPTIELKQMIGQAVTISLQPSGAIVGGSPRHFHGYVTQFSHTGADGGLATYSATVQPWLWMLSRRVDSRIFQDKSARDILDAVFSQYSALASYEFRAGRTLKPYSYCTQYRETDLNFVLRLMELEGLFFYFEHTEDGHKLIIDDDSTRAKPIDGPPSLRYASGEILEDEAVVTQWAAQRQLMSGAVSMKAYDYKVPAARRYVSGEADFNQGEVERYEIYDYVGLHGFDSTDRGEELARFRLESLAASGKTFSGTSTGRTLASGRYFELSAHYDHDNGPMQDRQFLLTNVRHHGVNNYQSSEGSGSYHASFQCIRKKIPFRPPLAHARPVIPGPQTAIVVGPKGEQIHTDALGRVKIQFHWDRIGQRNHGSSCWVRVSQPWAGGGFGSVQIPRIGDEVVVTFLDGNPDRPLIISSVYNAQNMPPWALPAGATQSGFLTRSHKGTAENANAIRFEDKLGEEEIWLHAERNQRIEVEHDESHTVGAKRTKTVGADEIVTIGGAQTHTITGARTQTIGADHTQTIKGAHKQNVAGTHTQVIGGNASITTTGPQPGAAGTVGDIEIQSSQGKIHLKAATEIIIEVGASVIHLKADGTIEISGPTHIGLNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LY1</accession>
    <name>Q63LY1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195487.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110890.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0881"/>
    <dbReference type="EnsemblBacteria" id="CAH38343">
        <property type="protein sequence ID" value="CAH38343"/>
        <property type="gene ID" value="BPSS0881"/>
    </dbReference>
    <dbReference type="GeneID" id="56597241"/>
    <dbReference type="KEGG" id="bps:BPSS0881"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7173"/>
    <dbReference type="eggNOG" id="ENOG50316R6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSPAFGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025421">
        <property type="entry name" value="DUF4148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13663">
        <property type="entry name" value="DUF4148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266153" evidence="2">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="11868" checksum="24942F0B0ED69F3E" modified="2004-10-25" version="1">MKSFVYAAVAASILATPLASFAQADQQPPLTREQVRSELVQLEQNGYKPEAGETQYPANVQAASQRMLPAQQTLTHADTSGYGVQPAGAAESGGRASRSPASPAFGHSIYFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M82</accession>
    <name>Q63M82_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528056.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110789.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0780"/>
    <dbReference type="EnsemblBacteria" id="CAH38240">
        <property type="protein sequence ID" value="CAH38240"/>
        <property type="gene ID" value="BPSS0780"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0780"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7032"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QICMTTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="12"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="482" mass="49506" checksum="01B24B169BA9BF8C" modified="2004-10-25" version="1">MIDRRMLIGGAWCEAEHGATFERRDPVTGALASRAPAASAADAERAVAAAHAAFPAWAALAPTERRRRLLKAADLMDARGAAFVAAGVAETGATPAWIGLNVALAANVLREAASMATRISGDVMPSDVPGNLALAVRAPCGVVLGIAPWNAPVILGTRALAMPLACGNTVVLKASELCPGVHALIGAALHDAGLGDGVVNVLTHAAADAPALVERLIADPRVRRVNFTGSTHVGRIVARLAAEHLKPALLELGGKAPVVVLDDADLDAAVDAIAFGAFFNQGQICMSTERVIAARAIADALVDKLAAKARTLAAGDPRAGLPLGAMVSRDAAARAAALVDDAASRGAALPLGCRVDGAIMQPTIVDRVTPDMRLYREESFAPVVAVLRAGDDEHAIALANDSAFGLAASVFGRDLARALAVARRIESGICHVNGPTVHDEAQMPFGGVKASGYGRFGGAASIAEFTELRWLTVQTAPRAYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MK5</accession>
    <name>Q63MK5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527911.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110666.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0647"/>
    <dbReference type="EnsemblBacteria" id="CAH38104">
        <property type="protein sequence ID" value="CAH38104"/>
        <property type="gene ID" value="BPSS0647"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0647"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6842"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FEYWARE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="16453" checksum="675550624AD8A3DC" modified="2004-10-25" version="1">MSHVTEIPAADSAAAVAHFAASLAFETDCRDVHDALACGAPDFVLLDVRGPEQYAAAHVPGALNLPHRKIIESKLSEFARDTCFVVYCAGPHCNGAARAALRLARLGRPVKLMLGGVTGWLDEGFALARGNGAPRRQGGVRQRTAGNDPLRNRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N53</accession>
    <name>Q63N53_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110466.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0443"/>
    <dbReference type="EnsemblBacteria" id="CAH37899">
        <property type="protein sequence ID" value="CAH37899"/>
        <property type="gene ID" value="BPSS0443"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0443"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4439"/>
    <dbReference type="eggNOG" id="ENOG502Z7RB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPVQYRD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alginate_exp" evidence="1">
        <location>
            <begin position="55"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="449" mass="49532" checksum="F1618B7466D15240" modified="2004-10-25" version="1">MQPGVRPGASCAKTRPAILFNRWQEDWSALADPCVPRRPLDALKYVPLFGRVDSYLSLGAGLRERLEVNDAPLFGLGRARGDTYVLQRVQVHADLRIAGHVQAFVQLEDARPFGKDNVGPVDRNRVDLRQAFVTYVDAIGSGAFKARVGRQEMAFDLQRFVSVRDGPNVRQAFDGIWADWEQGPWRLIGYATQPVQYRDDGAFDDVSNRNLTFSGVRIERQRVGPGDLSAYYSRYNRTQAQFLDGAGGEHRDVFDVRYAGKRRNVDWDIEGMYQTGRVGAQRIEAWAVGSLAGYTFAGVGWMPRIGLQVDAASGDRRPRDGRIETFNPLFPNGYYFALAGYTGYTNLIHVKPSLTLKPSSALTLLAAVGLQWRATTADAVYAQGATPVPGTAGRGGNWTGFYTQLRADWAVTANLAAALEVVHFQIGDALRAAGGRNADYVGAELKFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB0</accession>
    <name>Q63NB0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposon Tn2501 resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tnpR</name>
        <name evidence="7" type="ordered locus">BPSS0386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552315.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110409.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0386"/>
    <dbReference type="EnsemblBacteria" id="CAH37837">
        <property type="protein sequence ID" value="CAH37837"/>
        <property type="gene ID" value="BPSS0386"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0386"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6514"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRQMEGI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="191" mass="20880" checksum="8452F0D2D060655E" modified="2004-10-25" version="1">MSRTFAYARVSKIDQTATNQLHEIEAAGFAVDKRRVVTESISGSVGASQRPGFSKLLDKMEEGDVLIVTKLDRLGRNAMDVRATVETLAERSIRIHCLALGGVDLTSAAGRMTMQVLNAVAEFERDLSIERTQAGIARAKSEGKAMGRPSALTKQQQQDVRQRLHEGASVASLAKFYGTSRQTIMRVRDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NE9</accession>
    <name>Q63NE9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194622.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110370.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0350"/>
    <dbReference type="EnsemblBacteria" id="CAH37798">
        <property type="protein sequence ID" value="CAH37798"/>
        <property type="gene ID" value="BPSS0350"/>
    </dbReference>
    <dbReference type="GeneID" id="56597190"/>
    <dbReference type="KEGG" id="bps:BPSS0350"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6470"/>
    <dbReference type="eggNOG" id="COG4341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QHSLQCA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017670">
        <property type="entry name" value="Phosphonate_degrad_HDIG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03276">
        <property type="entry name" value="Phn-HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="20188" checksum="8FEF89F3E50AA005" modified="2004-10-25" version="1">MALTLDDIRMLFDRHGDIAYSGEPVTQREHALQSAQLAEQAGANDALIAAALLHDLGHLLNRRGETPTAHGIDDLHQYCVLPFLRPLFPDAVLEPIRLHVDAKRCLCAIDASYYARLSADSVRSLHLQGGVFSDAEAEAFLKRPYAPDAIRVRRWDDLAKMAGKPTPGLDHYMRAVARAAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NJ1</accession>
    <name>Q63NJ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531467.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110328.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0308"/>
    <dbReference type="EnsemblBacteria" id="CAH37756">
        <property type="protein sequence ID" value="CAH37756"/>
        <property type="gene ID" value="BPSS0308"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0308"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6414"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYSSMDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="473" mass="51355" checksum="B0A738CF24E22FA1" modified="2004-10-25" version="1">MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGMWCVTLGYGRREIADAIRDQALRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYLAASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPPGYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGNGVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPTPADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NP6</accession>
    <name>Q63NP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187340.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110273.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0254"/>
    <dbReference type="EnsemblBacteria" id="CAH37700">
        <property type="protein sequence ID" value="CAH37700"/>
        <property type="gene ID" value="BPSS0254"/>
    </dbReference>
    <dbReference type="GeneID" id="56597006"/>
    <dbReference type="KEGG" id="bps:BPSS0254"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6341"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="17621" checksum="8F08FD15FFA22DF4" modified="2004-10-25" version="1">MKVAIGCDEAAYALKESIKRHLRATHPELELVDFGTHSADEAVLYPDIAIEVAQRVAAGEFPRAILLCGTGIGVAISANKVPGIRAAQCHDTYSAERARRSNDAQIVTMGARVIGTELANSIVDAWLRAEFDGGRSQPKVQRIADYERRAGLTQAGPNDAHRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NR1</accession>
    <name>Q63NR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188612.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110258.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0239"/>
    <dbReference type="EnsemblBacteria" id="CAH37685">
        <property type="protein sequence ID" value="CAH37685"/>
        <property type="gene ID" value="BPSS0239"/>
    </dbReference>
    <dbReference type="GeneID" id="56596991"/>
    <dbReference type="KEGG" id="bps:BPSS0239"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6323"/>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPKFDYQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="202" mass="20839" checksum="D486454179325F4D" modified="2004-10-25" version="1">MHTLYLIAIVAEAMSGALMGMQRGMDRFGLALVGAVTALGGGTVRDVLLGRYPLTWVAHPEYLLLTLAAATFASMTATHVARLKSLFTAVDALGLAAFSIIGCDVAAAVNGSPVVIVLAGAITGVCGGMLRDLLCNEMPLVLRKELYASIALLTGGLYVGMKAIGAAQGFATVVALAVGFALRMLAVRRGWRLKAFQAADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NT1</accession>
    <name>Q63NT1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551249.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110238.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63NT1"/>
    <dbReference type="STRING" id="272560.BPSS0218"/>
    <dbReference type="EnsemblBacteria" id="CAH37663">
        <property type="protein sequence ID" value="CAH37663"/>
        <property type="gene ID" value="BPSS0218"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0218"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6290"/>
    <dbReference type="eggNOG" id="COG2942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGGWFYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="367" mass="39866" checksum="022FA36DA93A0F8A" modified="2004-10-25" version="1">MSAPVSVSDQAARLRRHFAQIVLPIWRGPGFNPALQLPFEAVAPDTHAPLPVTRYRAMACARQLFIFSQAGDAQHAHALFAALCRHFRDPRHDGWFYSVDAQGAPLDRTKDLYTHAFVVFACAEYFAAFGNRDARELAQRTAALIVDRFAPRPGSALLDSARGEDFAAAAGGPLQNPLMHLTEGWLAAGRAFGDTAFDDALLRTAQAVERTFVDPHTGCVAELPIGCADNRFEPGHQFEWFYLVASAGARLAATGLPDALARAYAFAQRHGVDPDTGGVSATTDERGACVDGTQRIWAQTEYLRALATHGGEPDALARQIARFAERFLHPRGWYECKTAQGEVSRADMPSTTPYHLATAYASLPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ2</accession>
    <name>Q63NZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110177.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0156"/>
    <dbReference type="EnsemblBacteria" id="CAH37601">
        <property type="protein sequence ID" value="CAH37601"/>
        <property type="gene ID" value="BPSS0156"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0156"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4091"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYKGWSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="253" mass="26489" checksum="2C7190D57F5CCEC1" modified="2004-10-25" version="1">MTTSPSPLPAVRAIVTGHTRGLGEALAEQLLRRDIAVLGLSRGRHPSLASHAPERLVEAELDLSEPARVQAWLGGDTLGAFVAGASRVLLFNNAGTVEPIGPLDTQDTAAIARAVGLNVATPLMLASALAKLAPDALERRIAHISSGAARNAYAGWSVYCATKAALDHHARAVALDANRALRICSVAPGVVDTGMQATIRATSDERLPSRERFARLKSSGALSTPDDAARQLIDYVLSDDFGSTPTADIRHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ5</accession>
    <name>Q63NZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate/aspartate periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gltI</name>
        <name evidence="4" type="ordered locus">BPSS0153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554722.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110174.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0153"/>
    <dbReference type="EnsemblBacteria" id="CAH37598">
        <property type="protein sequence ID" value="CAH37598"/>
        <property type="gene ID" value="BPSS0153"/>
    </dbReference>
    <dbReference type="GeneID" id="56596897"/>
    <dbReference type="KEGG" id="bps:BPSS0153"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4087"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DCATTTN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266494" evidence="2">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="38"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="32868" checksum="4099839235A55F5F" modified="2004-10-25" version="1">MMKPLRPLLSIAVGCALAAAAHANDAGPTLKKIRDTGVVTLGVRESSVPFSYYDQQQRTIGYSQEIALKIVDEIKKTLNRPNLTVREIPITSQNRIPLVQNGTVDLECGSTTHTKERANQVSFSNSIFQYGMRLIVKKSSGVKDFPDLAGKTVATTAGTTEERLLRQWNAEKGMAMQIISAKDHADAFLNVKSGRAVAFFMDEPLLYGAKAKEANPGDYVITGNSPVSEAYGCMLRKDDPGFKQLADRVIARMQRSGEAEALYVKWFNRPIPPKGVNLDYPLSADMKQLFANPNDKALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ8</accession>
    <name>Q63NZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110171.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0150"/>
    <dbReference type="EnsemblBacteria" id="CAH37595">
        <property type="protein sequence ID" value="CAH37595"/>
        <property type="gene ID" value="BPSS0150"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0150"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6200"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AALPMYN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="269" mass="28191" checksum="FDCDB5980E65F29B" modified="2004-10-25" version="1">MYNVTPRHAALWRSLLRDALHAFARAGGPADVTLLGEPSGEPDGELLPLWRRGDLLLSQTCGYPYRMLGVGDAVHLIATPVFDAAGCDGPRYCSMLAVSAGAHARGATTLAACRGLRAACNGDDSHSGMNALRHAIAPHARGGRFFSAVTRTGSHLSALRALDAGAADLAAIDCVTLAYVRDALPARLRRVRIIGATAAAPGLPFIASRALAGEHVGALRDALDAAVAIDAERARALRLRGFARLAPDAYAEIERFEREAVALGYPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P74</accession>
    <name>Q63P74_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939053.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110095.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="DNASU" id="3096894"/>
    <dbReference type="EnsemblBacteria" id="CAH37517">
        <property type="protein sequence ID" value="CAH37517"/>
        <property type="gene ID" value="BPSS0073"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0073"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6088"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYVRTCR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="245"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="38128" checksum="C4C0F55CDEB682EE" modified="2004-10-25" version="1">MKPVAMAVTRTAAQRPAPLHTIFITLEVMKRIGLSRETLLEGTGISPSDVERPNAMVTHAQEMVLFANALKATGNSAIGLHIGNEIPVTAYGLRAHAMLVSPTLGDAMRLAFEHPLLGISYFRMKLLIDGEVARIIVGGYTYRHDLLVINTDMCFTAVRRQMIDLIGRSPHFTRIGFAYPKPSHADSYSEYFSCPAIFDSEINFLEFDASILMTKLPLAHPIEYEVARKACEKREFELAHWMPTDLVGQLLCMMYENPISQDVFEFADRLGMSLRSLQRKLKDMGTSFSALQDLVRQDIASKYLTEKHYTAKEIAARLGYKNASAFSRAMRRWSKISVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY2</accession>
    <name>Q63PY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADP-dependent malic enzyme</fullName>
            <ecNumber evidence="13">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL3242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="13"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197904.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109836.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3242"/>
    <dbReference type="EnsemblBacteria" id="CAH37253">
        <property type="protein sequence ID" value="CAH37253"/>
        <property type="gene ID" value="BPSL3242"/>
    </dbReference>
    <dbReference type="GeneID" id="56594587"/>
    <dbReference type="KEGG" id="bps:BPSL3242"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1994"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPVHILN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
        <property type="entry name" value="ME_PTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="12">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="11">
        <location>
            <begin position="163"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH37253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="756" mass="80791" checksum="7FC660C3A0913168" modified="2004-10-25" version="1">MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKVVGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYAATTGARTLADAIAGADVFLGCSSAGVLKQDMVKTMADRPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIADMDAYREQLGTTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEMRLKKIGSKLVGGVDFEIVNPEDDPRYQQCWQAYHEIGARDGVTPEVAKAALRKFNTLIGAMLVHLGDAHGMICGMIDTYHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVNEQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPELEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVGPFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q02</accession>
    <name>RL7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">BPSL3222</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH37233" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37233.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198366.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109816.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q02"/>
    <dbReference type="SMR" id="Q63Q02"/>
    <dbReference type="STRING" id="272560.BPSL3222"/>
    <dbReference type="EnsemblBacteria" id="CAH37233">
        <property type="protein sequence ID" value="CAH37233"/>
        <property type="gene ID" value="BPSL3222"/>
    </dbReference>
    <dbReference type="GeneID" id="56594533"/>
    <dbReference type="KEGG" id="bps:BPSL3222"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2016"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000243401" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="124" mass="12559" checksum="497C452EA2CE02BE" modified="2006-06-27" version="2">MAIAKEDILAAVEGMTVLELNELVKAFEEKFGVSAAAVAVAGPAAGGAAAAAEEKTEFTVVLAEAGSNKVAVIKAVREITGLGLKEAKDLVDGAPKPVKEGVDKASADEAKKKLEDAGAKVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q70</accession>
    <name>Q63Q70_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL3155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3155"/>
    <dbReference type="EnsemblBacteria" id="CAH37165">
        <property type="protein sequence ID" value="CAH37165"/>
        <property type="gene ID" value="BPSL3155"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3155"/>
    <dbReference type="eggNOG" id="COG4178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRYGLVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="62"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="399"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="437"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH37165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="606" mass="67952" checksum="C49C17528C1EAD68" modified="2004-10-25" version="1">MPRAAPPASRRRPHIRKLMTQSMQASAPAPDDPTQPQPSVSTWSLIKPYWVSEEWKVAWGLLVTIVAINLTLVWINVRINSWSASFYNALQSKDVRDFPSLLITFAVLAFAFIILAVYGLYLRQMLGFRWRQWLTTRFLNEWLGDRNFYRIERDRLADNPDQRIADDLQSLASTTLSLSLDLLSTVVTLISFATILWSIAGAATISLGGHAITIPGYMVWVAMIYAIAGSYVMHRFGHPLVSINYQQQRVEADFRFSLIRIRENAEQIAFYNGEPVETAHEQGLFQRIRENWWRVMRYTKRLTFVLNFYAQLASLFPIAVAAPRYFAGAFTFGVLMQISRAFGTVSDSFSWFINSYGTLAEWRATVNRLREFKRVMGASHLKETMSPATEHGGINLHYVDARQITTSGLKLALPNGAALASIGDVAIEPGSRWLVRGPSGSGKSTLMRALAGLWPFGDGAIDAPVDARMMFVPQQSYLPIGTLKAALAYPSATDTFSDDACSEALRACGLADYVERLGETGHWTRILSPGEQQRLAGARVLLHKPDYLFLDEATSALDADNEARLYRLFDERLPKAAIVSIAHRESVASFHQQTLDVRRDEARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q95</accession>
    <name>Q63Q95_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202812.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109723.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3130"/>
    <dbReference type="EnsemblBacteria" id="CAH37140">
        <property type="protein sequence ID" value="CAH37140"/>
        <property type="gene ID" value="BPSL3130"/>
    </dbReference>
    <dbReference type="GeneID" id="56594098"/>
    <dbReference type="KEGG" id="bps:BPSL3130"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2113"/>
    <dbReference type="eggNOG" id="COG3671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQIRSFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="129" mass="14933" checksum="7B6126754DC577B3" modified="2004-10-25" version="1">MPESPNQFPPSYQSATESERQQSLRTLTHILYLLYAIHWLTGGITGIVAIIINYVKRDDAVGTAYQAHFEWQIRTFWRALIAYLIGFALLLVGIGFIVLGAVWIWTLYRIIKGWLYLNDNKTLDPQAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QB1</accession>
    <name>Q63QB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009932052.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109707.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3114"/>
    <dbReference type="EnsemblBacteria" id="CAH37124">
        <property type="protein sequence ID" value="CAH37124"/>
        <property type="gene ID" value="BPSL3114"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3114"/>
    <dbReference type="eggNOG" id="ENOG5033568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELWENPV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="29209" checksum="6CEF251DC0DAA03B" modified="2004-10-25" version="1">MSGVLTLSKQIADFAESDIPARATMHVNFYRLQCRHRKLTSGTAMRQTIVVSEPLDTEQELSQLGLKVSVAQKIAHAASAARASALEIDVAFTPGMLSHIYGNRQLRLELLPLGWRKGRFNNVESVINDELGIQIIFQNVDIACVPEHSPQAISGKGSGSRQLVQNGLQSELWENPVNPPTDPSQLESKRGVTPTVWMFCVSNDGKRLRAEVSKPSNFEGDQFEDFSKRIFVLDEESGTDPDISINPSSGGNDDADFDIDVSVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QD0</accession>
    <name>Q63QD0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Colicin V processing peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BPSL3093</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545619.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109688.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3093"/>
    <dbReference type="MEROPS" id="C39.005"/>
    <dbReference type="EnsemblBacteria" id="CAH37104">
        <property type="protein sequence ID" value="CAH37104"/>
        <property type="gene ID" value="BPSL3093"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3093"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2152"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDVMQSN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02419">
        <property type="entry name" value="Peptidase_C39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033838">
        <property type="entry name" value="CvaB_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="14">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="173"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="488"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="522"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH37104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="753" mass="81654" checksum="F930BA89014D56B7" modified="2004-10-25" version="1">MSLLDRLSFGIGSKLPMILQTEAAECGLACLAMIAGFHGHHVDLATMRTRFPVSLKGAGLGRVIDIAQRLDLGTRALKLDLEQLGQLRVPCMLHWNFNHFVVLKEISGKHAIVHDPAQGVRKLSLEEVSRSFTGVALELWPTGSFKPREASPAVKLRQLLGPVSGLSRSLGQILVLAVALEVFTLVSPFFLQWVIDEVIVSADRDLLTVLALGFGLLLLMQQATSAIRAWALMYLGTTLNVQWRANVFTHLLNLPVQYFERRHLGDVVSRFGSIDTIQQTMTTSFLSAVIDGLMTIVTLAMMFVYSRTLAFVALGTMALYALLRWLWYRPLRRATEDQIIHTAKQQSHFLETVRGVKTIKLFNRQTERRSSWLTLLVEQINASLHVQKLQLLYQQLNGLLFGLEGLVIIWLGARLVMDGEFTVGVLMAFNAYKGQFDSRVGSLIDKFFEVKMLQLQGERLSDIVFAKGEADAGGRHVPGETENLCASIEAENLVFRYAEGEPTVLDGVSLKIEPGESVALIGASGCGKTTLVNVLLGILEPTGGKIRIGGVDVERLGLDRLRSLVGTVLQDDVLFAGSIADNISFFDPDADPKWVAECAQLAAVHADIVAMPMGYNTLVGDMGTVLSGGQKQRVLLARALYKRPKILVLDEATSHLDLQRERQVNAAVSALKMTRVIVAHRPETIASASRVIMLDAGKVALDKPTAALAAAPRPPAAPAAAPASAEAQAAPAAACAAPAAPPAQAATQPATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI5</accession>
    <name>Q63QI5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fadD</name>
        <name evidence="4" type="ordered locus">BPSL3037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527788.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109633.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3037"/>
    <dbReference type="EnsemblBacteria" id="CAH37049">
        <property type="protein sequence ID" value="CAH37049"/>
        <property type="gene ID" value="BPSL3037"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3037"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2229"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIMPKFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="472"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="557" mass="60844" checksum="16C4B7628A640621" modified="2004-10-25" version="1">MDKIWLKSYPPGVPAEIDASRYSSVPDLLEESFGLYRNQQAFICMGKAITYGELDTLSRKLGAWFQSRGLPRGARVAIMMPNVLQYPVTIAAVLRAGYTVVNVNPLYTPRELEHQLKDSGAEAIVILENFATTLQAVIARTAVKHVVVAAMGDLLGLKGHLVNYVVRRVKKMVPAWSLPSYTRFNAALATGGRQTFKPAKPAPDDVAFLQYTGGTTGVAKGATLLHRNIVSNVLQAQAWHEPAHSKRPEVKQFITVIALPLYHVFALTVCGLLTLRTGGTGILIPNPRDIAGMIKELKGYPIITIPAVNTLYNALLNHPDFDQLDFSKLAVANGGGMAIQENVAKRWYEKTKTPIVEGYGLSETSPVATCNPVTATEYSGTIGLPLPSTEIAIRDDAGDDVPLGQPGEICIRGPQVMAGYWNRPDETAKVMMPDGFFKTGDVGVMDARGYVKIVDRKKDMILVSGFNVYPNEVEDVVASHPGVFEVAAVGVPDEHSGEAVKLFVVKKDPALTDKDLLAYCKDRLTGYKRPKYVEFRADLPKTNVGKILRRELRDGKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QK4</accession>
    <name>LPXC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="1">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="1">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxC</name>
        <name type="ordered locus">BPSL3018</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522022.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109614.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QK4"/>
    <dbReference type="SMR" id="Q63QK4"/>
    <dbReference type="STRING" id="272560.BPSL3018"/>
    <dbReference type="EnsemblBacteria" id="CAH37030">
        <property type="protein sequence ID" value="CAH37030"/>
        <property type="gene ID" value="BPSL3018"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3018"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2249"/>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVFYRSD"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000253652" description="UDP-3-O-acyl-N-acetylglucosamine deacetylase">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <sequence length="305" mass="33554" checksum="451B1FA9B7BB149F" modified="2004-10-25" version="1">MLKQRTIKSIVKTVGIGVHSGRKVELTLRPAAPDTGIVFSRVDLPTPVDIPASALSIGDTRLASVLQKDGVRVSTVEHLMSACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIEEQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFRLKFTIDFRHPAVDKTGQELEVDFANTSYVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKMLDAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEQAYEIVTFDDPKTAPTGFGFDAQTAFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QW4</accession>
    <name>RS9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsI</name>
        <name type="ordered locus">BPSL2910</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549989.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109504.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QW4"/>
    <dbReference type="SMR" id="Q63QW4"/>
    <dbReference type="STRING" id="272560.BPSL2910"/>
    <dbReference type="EnsemblBacteria" id="CAH36920">
        <property type="protein sequence ID" value="CAH36920"/>
        <property type="gene ID" value="BPSL2910"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2910"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2379"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000051190" description="30S ribosomal protein S9">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <sequence length="130" mass="14311" checksum="4617AFC9BA309666" modified="2004-10-25" version="1">MIGNWNYGTGRRKSAVARVFIKAGKGDIVVNGKPISDYFSRETSLMIVRQPLELTNHAQTFDIKVNVSGGGETGQAGAVRHGITRALIDYDATLKPALSKAGFVTRDAREVERKKVGLHKARRAKQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QY0</accession>
    <name>Q63QY0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase B</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dusB</name>
        <name evidence="14" type="ordered locus">BPSL2894</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10 11">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Dus family. DusB subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194278.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109488.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2894"/>
    <dbReference type="EnsemblBacteria" id="CAH36904">
        <property type="protein sequence ID" value="CAH36904"/>
        <property type="gene ID" value="BPSL2894"/>
    </dbReference>
    <dbReference type="GeneID" id="56593688"/>
    <dbReference type="KEGG" id="bps:BPSL2894"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2396"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02042">
        <property type="entry name" value="DusB_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032887">
        <property type="entry name" value="DusB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Dus" evidence="13">
        <location>
            <begin position="15"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="354" mass="38518" checksum="DD1C2BFBB25C3F37" modified="2004-10-25" version="1">MPVLGSHVLRNNLFVAPMAGVTDRPFRQLCKRLGAGYAVSEMVASNAQLWKSEKTMRRANHAGEVEPIAVQIAGADPAMMAEAARHNVANGAQIIDINMGCPAKKVCNVAAGSALLQNEPLVQRIVEAVVGAVGAGPDAVPVTLKIRTGWDRDHKNALRIATLAEAAGISMLTVHGRTRADLYRGDAEYDTIAAVKAAVRIPVVANGDITSPRKAKAVLDATRADALMIGRAAQGRPWLFREIDHFLQSGELLPPPRIDEIRQVMNEHLEDHYAFYGEFTGVRTARKHIGWYTRGLSGANGFRHRMNTLETTREQLAAVNEFFDAQQALSDRLVYVDDEDGDRGEPDDSNQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R19</accession>
    <name>Q63R19_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphonate metabolism PhnI protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phnI</name>
        <name evidence="2" type="ordered locus">BPSL2855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550010.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109449.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2855"/>
    <dbReference type="EnsemblBacteria" id="CAH36865">
        <property type="protein sequence ID" value="CAH36865"/>
        <property type="gene ID" value="BPSL2855"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2855"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2445"/>
    <dbReference type="eggNOG" id="COG3626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQFTRGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008773">
        <property type="entry name" value="PhnI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05861">
        <property type="entry name" value="PhnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007313">
        <property type="entry name" value="PhnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="404" mass="43527" checksum="C2FF20CDCCF6399A" modified="2004-10-25" version="1">MYVAVKGGERAIEASWRLLDQARRGDPAVPELSVEQIREQQRLAVARVMTEGSLYDEALAALAIKQAAGDLVEAIFLLRAYRTTLPRFGYTAPIDTGAMRLERRISATFKDIPGGQLLGPTYDYTQRLLDFALLAEGGAARHEPHEAESARAAADAGSPPPHATHAPPPAAARVIALLNDEGLIEEERPTAVGAEPGDLSREPLAFPADRATRLQNLARGDEGFLLAMGYATQRGYGHSHPFAGELRFGAVAVEMALDELDGETIEIGELDVTECQMINHFSGGDGEPPRFTQGYGLAFGHSERKAIAMALVDRALRASELGEAAHSPPQDQEFVLSHSDNVEASGFVQHLKLPHYVDFQSELELVRRLRAGHAAQAGAGAGANAHENAPARAERADTHTEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R52</accession>
    <name>Q63R52_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly(A) polymerase I</fullName>
            <shortName evidence="9">PAP I</shortName>
            <ecNumber evidence="9">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcnB</name>
        <name evidence="15" type="ordered locus">BPSL2821</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522151.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109416.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2821"/>
    <dbReference type="EnsemblBacteria" id="CAH36831">
        <property type="protein sequence ID" value="CAH36831"/>
        <property type="gene ID" value="BPSL2821"/>
    </dbReference>
    <dbReference type="GeneID" id="56528377"/>
    <dbReference type="KEGG" id="bps:BPSL2821"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2483"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMAKLDM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006378">
        <property type="term" value="P:mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00957">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010206">
        <property type="entry name" value="PolA_pol_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025866">
        <property type="entry name" value="PolyA_pol_arg_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12626">
        <property type="entry name" value="PolyA_pol_arg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01942">
        <property type="entry name" value="pcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="12">
        <location>
            <begin position="87"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="14">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_arg_C" evidence="13">
        <location>
            <begin position="375"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="515" mass="57595" checksum="212FC871259C2876" modified="2004-10-25" version="1">MIKKLIRKLLGQDARTAQDAPQDPAEPRSAAPAAPAGRAKPARGAAKKPRNGAPTIVHADVHGIDPALISKNAIRVTDTLQQAGFRAFIVGGAVRDLLLGIAPKDFDVATDATPTEVQRLFRRARLIGRRFQIVHVQFGQELIEVSTFRALVDAPQEPPADAAPAKRLKRDELDRRTHAVDASGRVLRDNVWGEQHEDAARRDFTINAMYYDPASQTVLDYHDGMADMRARLLRMIGDPATRYREDPVRMLRVVRFAAKLGFDIEEKTREPIKELADLINNVPAARLFDEMLKLLLSGHALACLKQLRKQGLHHGLLPLLDVVLEQPQGEKFVTLALNNTDARVRAGKPVSPGFLFATLLWHDMRQRFEQYSADGEFPVPALHRAMDDVIDMQTEKLAIHKRYSADMREIWGLQLRLEKRSGRSALRLLEHQRFRAGYDFLLLRCESGELDPAVGQWWTDFIDGDAATREALLTQGGSRDKSPRKRRRRGGRSRRTADSAEGAEGAARGESDAND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RP5</accession>
    <name>RISB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="1">DMRL synthase</shortName>
            <shortName evidence="1">LS</shortName>
            <shortName evidence="1">Lumazine synthase</shortName>
            <ecNumber evidence="1">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ribH</name>
        <name type="ordered locus">BPSL2627</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186056.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109223.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RP5"/>
    <dbReference type="SMR" id="Q63RP5"/>
    <dbReference type="STRING" id="272560.BPSL2627"/>
    <dbReference type="EnsemblBacteria" id="CAH36635">
        <property type="protein sequence ID" value="CAH36635"/>
        <property type="gene ID" value="BPSL2627"/>
    </dbReference>
    <dbReference type="GeneID" id="56594849"/>
    <dbReference type="GeneID" id="66548033"/>
    <dbReference type="KEGG" id="bps:BPSL2627"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2725"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000040385" description="6,7-dimethyl-8-ribityllumazine synthase">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="173" mass="18810" checksum="F606F2BDE5F44629" modified="2004-10-25" version="1">MEIGQYQPNLEGDGLRIGIVQSRFNEPVCNGLADACVEELERLGVSGEDVLLVTVPGALEIPLALQKLAESNQFDALIALGAVIRGETYHFELVSNESGAGITRIALDFNTPIANAVLTTETDEQAIARMTEKGRDAARVAVEMANLTMTLDQLSDDEEDEEDEDDEDEEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RQ0</accession>
    <name>Q63RQ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109217.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2621"/>
    <dbReference type="EnsemblBacteria" id="CAH36629">
        <property type="protein sequence ID" value="CAH36629"/>
        <property type="gene ID" value="BPSL2621"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2621"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2988"/>
    <dbReference type="eggNOG" id="ENOG502ZS95">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMMEQIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="22432" checksum="C7137BFF3B42F671" modified="2004-10-25" version="1">MSIVREPSSGRRTRRRTHGYIAGSTRSDGGIAMQRDRHTRWLLTSGDIRKDAPFFGTLGVLIGVAQLVGFRCFHKADWGTKLLFEHIVFDTLIVALIVVWLARIPTEWLRIERKREFPMLDKLIAHVARRAASFAVTAASVVAGVAAVAALSGSPVHAVKFAFFCAYLLSIGEAVLNPLIAPGQSRLNGVAKALLIGMPLGFQLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU8</accession>
    <name>Q63RU8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
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                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
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                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CAH36580">
        <property type="protein sequence ID" value="CAH36580"/>
        <property type="gene ID" value="BPSL2572"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2572"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2935"/>
    <dbReference type="OMA" id="IRTEEMF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="11781" checksum="68CD6C94D5EB0B68" modified="2004-10-25" version="1">MGMDSEAHMKALRRRVERLLESIDRNASERRASVVLGDLERQIRMEEMFARAAVRGVTGTLEELAARSAIGEHYDLDELSDGESACRVAVLLLRAKQRKLAAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ0</accession>
    <name>Q63RZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent formate dehydrogenase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdsD</name>
        <name evidence="1" type="ordered locus">BPSL2531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190152.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109127.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2531"/>
    <dbReference type="EnsemblBacteria" id="CAH36538">
        <property type="protein sequence ID" value="CAH36538"/>
        <property type="gene ID" value="BPSL2531"/>
    </dbReference>
    <dbReference type="GeneID" id="56528652"/>
    <dbReference type="KEGG" id="bps:BPSL2531"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2848"/>
    <dbReference type="eggNOG" id="ENOG5032Z86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFEAMPD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021074">
        <property type="entry name" value="Formate_DH_dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11390">
        <property type="entry name" value="FdsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9520" checksum="E1533D86FA2BAC19" modified="2004-10-25" version="1">MESRHLIDMANQIGAFFASMPDHDEAVAGIADHIRRFWEPRMRRALLAALDDPQDEAARDVAPIVREAIDTHRASLEPAPVAPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S38</accession>
    <name>Q63S38_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109079.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2484"/>
    <dbReference type="EnsemblBacteria" id="CAH36490">
        <property type="protein sequence ID" value="CAH36490"/>
        <property type="gene ID" value="BPSL2484"/>
    </dbReference>
    <dbReference type="GeneID" id="56596474"/>
    <dbReference type="KEGG" id="bps:BPSL2484"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2900"/>
    <dbReference type="eggNOG" id="ENOG5032Y5P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CELHNRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="11069" checksum="7B759B4092F56EE3" modified="2004-10-25" version="1">MRLKAPDLATAQHWANVLGVAGVGCELHNCYAPGALGGLPIDACQPEIWLDDERDEALARRLIEAASAGPAAGAAPWRCARCGETLDAQFTACWHCGASRDPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE2</accession>
    <name>Q63SE2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bo(3) ubiquinol oxidase subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome o ubiquinol oxidase subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Oxidase bo(3) subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquinol oxidase polypeptide IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquinol oxidase subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cyoD</name>
        <name evidence="16" type="ordered locus">BPSL2381</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooctamer of two A chains, two B chains, two C chains and two D chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase bacterial subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192747.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108974.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2381"/>
    <dbReference type="EnsemblBacteria" id="CAH36383">
        <property type="protein sequence ID" value="CAH36383"/>
        <property type="gene ID" value="BPSL2381"/>
    </dbReference>
    <dbReference type="GeneID" id="56596289"/>
    <dbReference type="KEGG" id="bps:BPSL2381"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3024"/>
    <dbReference type="eggNOG" id="COG3125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYHMMIN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009486">
        <property type="term" value="F:cytochrome bo3 ubiquinol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014210">
        <property type="entry name" value="Cyt_o_ubiqinol_oxidase_su4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02847">
        <property type="entry name" value="CyoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH36383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="110" mass="11811" checksum="630965738386D672" modified="2004-10-25" version="1">MAHSHPSHGDEAHGTVGGYIAGFVLSVLLTAASFGLVMGGVLPPREALVSLAVLAAVQIVVHLVYFLHMNTSSSQRWNVMAFSYTVLTALILIFGTVWVMHNVGMNMMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SF8</accession>
    <name>Q63SF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108958.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2365"/>
    <dbReference type="EnsemblBacteria" id="CAH36367">
        <property type="protein sequence ID" value="CAH36367"/>
        <property type="gene ID" value="BPSL2365"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2365"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2691"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLEICNI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="230" mass="25794" checksum="CC79322AFA139C5D" modified="2004-10-25" version="1">MMKESKIPVQDFLARLPLFSVLSRGELDNLARGTMRVQVPRGQTVFSRGDPCGGFHMIVYGQIKLSSFSPLGIEKIVRLLGPGDSFGEAVMFMDKPYAVTAKALSDTLLLHVTKAVVTEELDHNPAFARRMLASLSMRLHQLVVDVETYSLRSGTQRVISYLLEQTDAPVESGMQIRLETGKKAIASRLNLTPEHFSRVLRDLCTRELVVVNGRDIFIPDVDRLRSEMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SH4</accession>
    <name>Q63SH4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550164.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108942.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2346"/>
    <dbReference type="ESTHER" id="burma-a5tj72">
        <property type="family name" value="UCP037442"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36349">
        <property type="protein sequence ID" value="CAH36349"/>
        <property type="gene ID" value="BPSL2346"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2346"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3072"/>
    <dbReference type="eggNOG" id="COG4757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQFAYWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017208">
        <property type="entry name" value="UCP037442_abhydr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037442">
        <property type="entry name" value="UCP037442_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="51"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="336" mass="37211" checksum="EF64BE912438BA58" modified="2004-10-25" version="1">MQDSQPDALPPEPFVAPAADGFPVRGFAWRHRAPAAGRPVTVINCATSVRCRYYFRFAAYLFSQGSDVLVYDYRGIGESRPASLAGFHATWLDWGRLDCDAVLQYAARTCAGQPVDVVAHSVGGVVLGLAASNPIVRRALTVGAQYAYWRDYAGSHRLRMLAKWHVAMPMLARVFGYVPAKRLGWMEDTPRGVALSWSRSRPRFEDAYVRAPIRETPDARRDLVERFTRLTAPMLAIGLSDDEFGSVEAVERLLGYYTRSAVTHLRIAPEQIGVASIGHFAFFHSRFEQTLWPIALGWLKTGALAPETPGRVHRQPCAPEPARAARDEASGRTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SK9</accession>
    <name>Q63SK9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative respiratory nitrate reductase delta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108907.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2311"/>
    <dbReference type="EnsemblBacteria" id="CAH36314">
        <property type="protein sequence ID" value="CAH36314"/>
        <property type="gene ID" value="BPSL2311"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2311"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3113"/>
    <dbReference type="eggNOG" id="COG2180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CELFDRG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="225" mass="24363" checksum="BD61C27348166407" modified="2004-10-25" version="1">MSIYPILSALLTYPEQPLLDALPEIERALDAQPGARAALAPLVESLRATPLIELQERYVATFDRTPSHSLHLFEHVHGESRDRGQAMVDLLDEYRRHGFEPVGNELPDYVPLFVEFLGAIAGDGDDAHAAHLLGDAIDVLAALGERLARAQSPYAGAFDVLRACSPVEPRPVAEPPPRTMDEALERFGPGPDGVEPLLSPAADASLAQPIRFHPPRRAATPAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SN6</accession>
    <name>Q63SN6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fdx</name>
        <name evidence="5" type="ordered locus">BPSL2284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193872.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108880.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2284"/>
    <dbReference type="EnsemblBacteria" id="CAH36287">
        <property type="protein sequence ID" value="CAH36287"/>
        <property type="gene ID" value="BPSL2284"/>
    </dbReference>
    <dbReference type="GeneID" id="56596078"/>
    <dbReference type="KEGG" id="bps:BPSL2284"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3145"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SACGGVC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011536">
        <property type="entry name" value="Fdx_isc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02007">
        <property type="entry name" value="fdx_isc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="12410" checksum="35AC5E7E4126BDC5" modified="2004-10-25" version="1">MPQLVVLPHVELCPDGAVIDAMPGKSICDTLLENGVEIEHACEKSCACTTCHVIIREGFNELDPSEEDEDDLLDKAWGLEPTSRLSCQAIVKEGVDLVVEIPKYSINHAKENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SQ9</accession>
    <name>Q63SQ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BPSL2261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938137.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108857.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2261"/>
    <dbReference type="EnsemblBacteria" id="CAH36264">
        <property type="protein sequence ID" value="CAH36264"/>
        <property type="gene ID" value="BPSL2261"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2261"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3170"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEIMHGL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH36264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="221" mass="23742" checksum="61E25379C481F0EE" modified="2004-10-25" version="1">MDASSLIQTIAVYALPVVFAITLHEAAHGYVARLLGDNTAYMMGRVSFNPMRHIDPFGTIVIPLVLYFLTSGAFLFGYARPVPVTFRNLRNPRWGSLWVVLAGPGCNFVQALIWGFVSIGLAALAVDEPFFTRMAGAGVGVNLVLAVLNLFPLPPLDGGRVLAALLPPKQSIALSRLEPYGFFIVLALVATGLLTKLWLRPLVGAGYAVVTAILTPFASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SR2</accession>
    <name>Q63SR2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ordered locus">BPSL2258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191516.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108854.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63SR2"/>
    <dbReference type="STRING" id="272560.BPSL2258"/>
    <dbReference type="EnsemblBacteria" id="CAH36261">
        <property type="protein sequence ID" value="CAH36261"/>
        <property type="gene ID" value="BPSL2258"/>
    </dbReference>
    <dbReference type="GeneID" id="56596052"/>
    <dbReference type="KEGG" id="bps:BPSL2258"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3173"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="31796" checksum="9AB82F4266A3E3F1" modified="2004-10-25" version="1">MANGTQDGIQIRGSVPAIVTPMLEDGGLDLAAFRKLIDWHIEEGTDALVVVGTSGESATLSVDEHVLMIETAVKHAAKRIPIVAGAGGNSTTEAIELSKHAKAVGADATLQVVPYYNKPTQEGIYRHFKAIAEAVDLPVILYNVPGRTVADMSNETTLRLAQVPGIIGVKDATGNIDRAAQLIKAAPAHFSIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALAADVKTAREIHMKLLSLHKHLFIEANPIPVKWALQQMGKIAGGIRLPLTPLDERCHETVRGALREAGLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SS8</accession>
    <name>SYC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">BPSL2243</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192752.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108838.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SS8"/>
    <dbReference type="SMR" id="Q63SS8"/>
    <dbReference type="STRING" id="272560.BPSL2243"/>
    <dbReference type="EnsemblBacteria" id="CAH36245">
        <property type="protein sequence ID" value="CAH36245"/>
        <property type="gene ID" value="BPSL2243"/>
    </dbReference>
    <dbReference type="GeneID" id="56596034"/>
    <dbReference type="KEGG" id="bps:BPSL2243"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3194"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000159370" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="465" mass="52366" checksum="ACB712456C778065" modified="2004-10-25" version="1">MESLRIYNTLARDKQDFVPRQPGEVRMYVCGITVYDYCHIGHARMVVVFDIVQRWLRARGYRVTYVRNITDIDDKIIRRAVENGETIQSLTRRFTDAMNADFDALGVERPDLEPRATEFIPQMLGMIEKLEANGYAYQAKDGDVNYSVRKFANYGRLSGKSLEDLRAGERVAANDAKEDPLDFVLWKRAKPQEPAGASWESKYGAGRPGWHIECSAMGCTLLGAHFDIHGGGQDLQFPHHENEIAQSEGATGQTFVNYWMHNGFVQVDSEKMSKSLGNFFTIREVLEKFDAEVVRFFIVRTHYRSPLNYSDVHLDDARASLTRLYTALKDATPDAQPLDWSEAHAQRFAAAMNDDFNTAVAVAVLFELATEVNRTREPALARQLRLLAGLLGLLGREPREFLQHAAGAARTGALEPHEIEARIAARVAAKQAKNYAEADRIRAELLEAGIALEDKPGGSTEWRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T31</accession>
    <name>Q63T31_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="10">PEP synthase</shortName>
            <ecNumber evidence="6 10">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppsA</name>
        <name evidence="14" type="ordered locus">BPSL2140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193522.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108735.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2140"/>
    <dbReference type="EnsemblBacteria" id="CAH36142">
        <property type="protein sequence ID" value="CAH36142"/>
        <property type="gene ID" value="BPSL2140"/>
    </dbReference>
    <dbReference type="GeneID" id="56595924"/>
    <dbReference type="KEGG" id="bps:BPSL2140"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3316"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LETWFFL"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="392"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="489"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH36142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="799" mass="87769" checksum="4A3DA6232E6A64C3" modified="2004-10-25" version="1">MTNAANVAKDQAYVIPFEQLRMTDVEIVGGKNASLGEMISQLAEAGVRVPTGFATTALAFRDFLQHNNLTERIAQRLESLDIDDVKALAEAGAEIRKWIVDAPLQPRLEQEIRAQFEILKNGSPGELSFAVRSSATAEDLPDASFAGQQESYLNVVGIEDVLDRMKHVFASLYNDRAISYRVHKGFTHAEVALSAGVQRMVRSDVGAAGVMFTIDTESGFKDAVFITASYGLGETVVQGAVNPDEFYVFKTTLAQDKYPIIRRSIGSKLIKMEFTQPGEPGRVKTVDVPHEQRNRYSITDDDVIELAKYAVIIEKHYQRPMDIEWGKDGRDGKIFILQARPETVKSQAHGKVEQRFKLKGQSQVLATGRAIGQKIGAGPVRVIHDPSEMERVQPGDVLVADMTDPNWEPVMKRASAIVTNRGGRTCHAAIIARELGVPAVVGCGDATDVLKDGALVTVSCAEGDEGKIYDGLLETEVSEVQRGELPSVPVKIMMNVGNPQLAFDFSQLPNAGVGLARLEFIINNNIGVHPKAILEYPNVDADLKKAVESVARGHASPRAFYVDKLTEGIATIAAAFYPKPVIVRLSDFKSNEYKKLIGGSRYEPDEENPMLGFRGASRYIAEDFAQAFEMECMALKRVRDEMGLTNVEIMVPFVRTVKQAERVVGLLGKFGLKRGDNGLRLIMMCEVPSNAILAEEFLQHFDGFSIGSNDLTQLTLGLDRDSGMELLAVDFDERDPAVKFMLKRAIDTCRKLDKYVGICGQGPSDHPDFAKWLADEGIASISLNPDTVIETWQALAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T52</accession>
    <name>Q63T52_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108714.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2117"/>
    <dbReference type="EnsemblBacteria" id="CAH36120">
        <property type="protein sequence ID" value="CAH36120"/>
        <property type="gene ID" value="BPSL2117"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2117"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2403"/>
    <dbReference type="eggNOG" id="COG3195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KICHLRL"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="7">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="174" mass="19088" checksum="A543A8E51B2FE995" modified="2004-10-25" version="1">MMKAMHYTLEQLNAMSTDAFVAALSGIFEHSPWVAEAAAAARPFGSIDALHGTMKDAVEAAGDARQLALINAHPELAGKAAVRGELTAESTREQSGAGLDRCTQAEFDRLQQLNRAYREKFGFPFILAVRGFDRHGIIANFEARVGHTRDEELRASLAQIYRIARFRLDDLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TE3</accession>
    <name>Q63TE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196717.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108623.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2026"/>
    <dbReference type="EnsemblBacteria" id="CAH36025">
        <property type="protein sequence ID" value="CAH36025"/>
        <property type="gene ID" value="BPSL2026"/>
    </dbReference>
    <dbReference type="GeneID" id="56595368"/>
    <dbReference type="KEGG" id="bps:BPSL2026"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3"/>
    <dbReference type="eggNOG" id="COG5430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VTNDCQI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007893">
        <property type="entry name" value="Spore_coat_U"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05229">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00972">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267537" evidence="1">
        <location>
            <begin position="28"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SCPU" evidence="2">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SCPU" evidence="2">
        <location>
            <begin position="259"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="321" mass="32956" checksum="4EC2CAB3D9CCDDC8" modified="2004-10-25" version="1">MTPFRLFFVRIAATLALGLFSALHAHATCSVVSAAAASFGTVTSFAVARQPQSTSTTSSGLSCSGALLGLFVIGDQINASITSANGGKLVGPTGDAVPYTVFADQNYSIKLDLGVTYNWASGQLLNLLGIFGGPAQTLPMYFRTVQGSNVAAGTYTDTLTIAWNWDYCSGIGVLGICLGRDRGSGTAVVPVTITVTNDCMIAAPDVNFGAAPTVASFAPVTGSVSLTCTKGMVYTVGLSSGANPHASGRRQMANGANRLQYDIFGPGAAAVWGQSANRAGSGAAADGRSAQQFPYTARLYPDQPTPAVGTYTDSVVVDVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TG6</accession>
    <name>Q63TG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192588.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108600.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2002"/>
    <dbReference type="EnsemblBacteria" id="CAH36001">
        <property type="protein sequence ID" value="CAH36001"/>
        <property type="gene ID" value="BPSL2002"/>
    </dbReference>
    <dbReference type="GeneID" id="56595394"/>
    <dbReference type="KEGG" id="bps:BPSL2002"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4155"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMSAAFN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="382" mass="39863" checksum="64DD5AE0A8564236" modified="2004-10-25" version="1">MAYIYYLTHIHLGDDALAMLGAECARSGIARPLVVTDKGVAAAGLVDRALEALGLGALPVFDDTPSNPTEAAVLAAAQRYRDEGCDGLVAVGGGSAIDLAKGVAIAATHPAPLTRYATIEGGSERITAAAAPLIAVPTTSGTGSEVARGAILILADGRKLGFHSWHLLPKAAICDPSLTLGLPPGLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATHDGGDRAARLAMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTSLHHGTLNAVVLPAVLRFNESAPSVVAERRYARMRRVMNLPERADLSQALHDMTARLGLPTGLRQMGVDEQAFDHVIEGALADHCHKTNPRIASADDYRRMLVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH3</accession>
    <name>Q63TH3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TPP-binding acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526811.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108593.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1995"/>
    <dbReference type="EnsemblBacteria" id="CAH35994">
        <property type="protein sequence ID" value="CAH35994"/>
        <property type="gene ID" value="BPSL1995"/>
    </dbReference>
    <dbReference type="GeneID" id="56526361"/>
    <dbReference type="KEGG" id="bps:BPSL1995"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2247"/>
    <dbReference type="eggNOG" id="COG3962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PNTYHLE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="34"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="247"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="447"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="661" mass="69661" checksum="E412D52456A5D30A" modified="2004-10-25" version="1">MNRRAMDDDTRRSPSVNDFIDDPAASVQRTVRLTAAQALVRYLAAQRVATGDGDAPLFGGVFAIFGHGNVAGLGEALHQYRDALPTYRAHNEQAMAHSAIAYAKAHLRRRMMAVTTSIGPGATNLVTAAALAHVNRLPVLLLPGDVFVSRAPDPVLQQIEDFHDGAISANDAFKAVSRYFDRIVHPAQLLTALPRALRVLTDAALCGPVTLALPQDVQTMAYDYPAEFFAPRAVTFHAPAPVEAELDAALAPLRASARPFIVAGGGALYSEGGAAALAAFAERHGIPVGETQAGKSALPWDHPLNAGAIGVTGSPAANALAHDADCVIAVGTRLQDFTTGSNTLFARARVIGINANAFDALKHRATIVQADARLALDALGARLEGWRADAAWTARAHARANAWRDAVAAVTHAPPRARALPYDADVIGAVQRSAPDSAARDIAVCAAGTLPAELHKLWRAAAPGGYHVEYGYSCMGYEIAGGLGAKLAKPEREVIVMVGDGSYLMMNSEIATSVMLGAKLIVVVLDNRGYGCINRLQQACGGAPFNNLFDDCVQGPLGAPRIDFAAHARALGARAEHVADIAALEAAMARARASDRTYVICIDTDPARTTPDGGWWWEVAVPEVSPRDAVRDARADYERHLAARAGAPASRSTPSTPESST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TI8</accession>
    <name>SYV_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Valyl-tRNA synthetase</fullName>
            <shortName evidence="1">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">valS</name>
        <name type="ordered locus">BPSL1980</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521705.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108578.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TI8"/>
    <dbReference type="SMR" id="Q63TI8"/>
    <dbReference type="STRING" id="272560.BPSL1980"/>
    <dbReference type="EnsemblBacteria" id="CAH35979">
        <property type="protein sequence ID" value="CAH35979"/>
        <property type="gene ID" value="BPSL1980"/>
    </dbReference>
    <dbReference type="GeneID" id="56526346"/>
    <dbReference type="KEGG" id="bps:BPSL1980"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4132"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224453" description="Valine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="887"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="542"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <sequence length="955" mass="106726" checksum="FA96C0FA6861576C" modified="2004-10-25" version="1">MSDTTLAKSFEPQTIESQWGPEWEKRGYATPALDPSRPDFSIQLPPPNVTGTLHMGHAFNQTIMDGLVRYHRMLGHNTLWVPGTDHAGIATQIVVERQLDAQGVSRHDLGREKFVERVWEWKERSGSTITGQVRRIGASPDWSREYFTMNDKMSEAVREVFVRLYEQGLIYRGKRLVNWDPVLLTAVSDLEVVSEEENGHLWHIRYPLADGSGHLSVATTRPETMLGDVAVMVHPEDERYRHLVGRHVKLPLCEREIPIIADDYVDREFGTGVVKVTPAHDFNDYQVGLRHALAPIEILTLDAKINDNAPAAYRGLDRFDARKAIVDELDAQGLLESVKPHKLMVPRGDRTGVVIEPMLTDQWFVAMTKPAPQGTFHPGKSITEVSLEVVRRGEIKFVPENWTTTYYQWLENIQDWCISRQLWWGHQIPAWYGENGEIFVARNEEDARAQAAAKGYTGALKRDDDVLDTWFSSALVPFSSLGWPNETPEMKHFLPSSVLVTGFDIIFFWVARMVMMTTHFTGKVPFGTVYVHGLVRDAEGQKMSKSKGNTLDPIDIVDGIGLDALVAKRTTGLMNPKQAATIEKKTRKEFPDGIPAFGTDALRFTMASMATLGRNVNFDLARCEGYRNFCNKLWNATRFVLMNCEGHDCGFDKPEVCGAGDCGPGGYLDFSPADRWIVSLMQRVEADIAKGFADYRFDNIANAIYKFVWDEYCDWYLELAKVQIQNGTPEQQRATRRTLLRVLETVLRLAHPIIPFITEALWQKVAPLAGRYPAGKAEGEASLMVQAYPVAEPKKLDEACEQWAAELKAVVDACRNLRGEMNLSPATKVPLLAAGDAAQLQAFAPYVQALARLSEVRVLPDEAALDADAHGAPIAIVGGNKLVLKVEIDVAAERERLSKEIARLEGEIVKCNAKLGNEAFVAKAPPAVVAQEQKRLAEFQSTLTKLGAQLARLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TV8</accession>
    <name>Q63TV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550533.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108458.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1859"/>
    <dbReference type="EnsemblBacteria" id="CAH35858">
        <property type="protein sequence ID" value="CAH35858"/>
        <property type="gene ID" value="BPSL1859"/>
    </dbReference>
    <dbReference type="GeneID" id="56529551"/>
    <dbReference type="KEGG" id="bps:BPSL1859"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2094"/>
    <dbReference type="eggNOG" id="ENOG5033646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NAMWGWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="16411" checksum="70A8B2117FF7FE4C" modified="2004-10-25" version="1">MAPRLHVALSMQKVILPFLSGFLAALFFREATLALLHTAGLIDATGFSTTPFAPLGIPEFVANAIMSACWAILMAWLLRVSPERAAPWVPSLVFGGIVLTAARVFAIDPLRGIWPAGNMLPPLVVGFVANAVWGWGALVFMRAFMSDDGGSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TW4</accession>
    <name>Q63TW4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521630.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108452.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1853"/>
    <dbReference type="EnsemblBacteria" id="CAH35852">
        <property type="protein sequence ID" value="CAH35852"/>
        <property type="gene ID" value="BPSL1853"/>
    </dbReference>
    <dbReference type="GeneID" id="56529545"/>
    <dbReference type="KEGG" id="bps:BPSL1853"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3985"/>
    <dbReference type="eggNOG" id="ENOG50316KW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMGDYQE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="84" mass="9379" checksum="C593F50A3500EF3C" modified="2004-10-25" version="1">MEPKGRDIGDFGEPYKGYDIEVKTEQVWAGEKAHYRVLQGGAVMIDWRLVHIDGLLLSERRVIEQTLAVARSAVDRELLGAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX5</accession>
    <name>Q63TX5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521621.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108441.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1842"/>
    <dbReference type="EnsemblBacteria" id="CAH35841">
        <property type="protein sequence ID" value="CAH35841"/>
        <property type="gene ID" value="BPSL1842"/>
    </dbReference>
    <dbReference type="GeneID" id="56529532"/>
    <dbReference type="KEGG" id="bps:BPSL1842"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3969"/>
    <dbReference type="eggNOG" id="ENOG50330RP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQTVNQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021330">
        <property type="entry name" value="DUF2939"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11159">
        <property type="entry name" value="DUF2939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="244" mass="24938" checksum="255C483CD9819695" modified="2004-10-25" version="1">MNSIARPRGRFLKPVAIGIALIVVAAVALYAYASPYLALRQMKQAIDARDAQAISVHVDFPALRISLKQQLTDELMRRIDAQKRDNPLAILGAMIGSALVGPLVDAYATPDGVAALMSGLPPHARPGQRPPELNPPSDPASAAAAGTGAPPGNAGVPGSASGAAEQTASAAAASTSGASGTSGTPPGAPSATPGPSPQTSAGYRGFDEFVVTYRRDDGSARYAAVFRRSGIFGWKLSAIDLHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX9</accession>
    <name>Q63TX9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysT</name>
        <name evidence="11" type="ordered locus">BPSL1838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555914.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108437.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1838"/>
    <dbReference type="EnsemblBacteria" id="CAH35837">
        <property type="protein sequence ID" value="CAH35837"/>
        <property type="gene ID" value="BPSL1838"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1838"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3964"/>
    <dbReference type="eggNOG" id="COG0555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VFISGNM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="62"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="31752" checksum="12FFD55CC9463550" modified="2004-10-25" version="1">MTTFTFRKPSALPGFGVTLGITLAYLSLVVLIPLAATFLKTATLTWDQFVAATTSPRVLASYRLTFSAALGGALVNAVFGFLVAWVLVRYTFPLKRQVDAIVDLPFALPTSVAGISLAAVYAQNGWIGRYLAPLGIKVAFTPFGVLVALTFIGLPFVVRTVQPVLEDFEREQEEAAACLGASRWLTFRRVVLPAVTPALLTGFALAFARALGEYGSVIFIAGNVPMKSEITSLLIITKLEQYDYAGATALAVVMLVVSFVMLLLINTLQWYLQRRTSRGASGPTPAAHAATALGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U57</accession>
    <name>Q63U57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531267.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108359.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1759"/>
    <dbReference type="EnsemblBacteria" id="CAH35758">
        <property type="protein sequence ID" value="CAH35758"/>
        <property type="gene ID" value="BPSL1759"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1759"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3860"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HLTIDQA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012798">
        <property type="entry name" value="Cbl_synth_CobG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02435">
        <property type="entry name" value="CobG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="113"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="303"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="482" mass="48775" checksum="4D52B962FBCBBD12" modified="2004-10-25" version="1">MNPSAAVFSSAAARAASACPGLVRIVAARDGGLCRIKLPGGALTAAQARAVAAVARAFGSGVIEATNRANLQVRGVKAGREASASRALIDAGLGPLMDGASAASLEACAAARDDVRNVMLSPTAGRDPDALVDSAALAARLLAMLQTEPRCAALSPKFSVLLDGGERLAALDHPHDIWLSALRDAHGAPVDTQFAIGLAGCPPVDGGQAAPGAPCAGALAAVAPEHAVECVRALVTSFVELAPAGATRMRELLATCPPDAFLSHVESKLSESKQPFALRRDAHLAGWRRARVDAALRLGILPERDPARCAVGAQPPLGRLDAAALAALAALADTHGDGTLRITPWQGVMLPAVARAAAPEALARLAALGFVCDAAAPLAHIVACAGSRGCARSPADTKAHALALAARLAAPVDVHVTGCARSCALPHAAAHTLVASAASRYDLYRRDGATGFGRAVARQLTIDQAADALARGARPSQDDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UF1</accession>
    <name>Q63UF1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108265.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1655"/>
    <dbReference type="EnsemblBacteria" id="CAH35652">
        <property type="protein sequence ID" value="CAH35652"/>
        <property type="gene ID" value="BPSL1655"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1655"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1866"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAMAGFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Porin_4" evidence="7">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="372" mass="39537" checksum="3E613E20372E1D16" modified="2004-10-25" version="1">MAGCLLPGIATAQSSVTLYGVIDEGIDYVNNSGGQHLWRMRDGTYDGMYGSRWGLKGSEDLGGGLSALFKLEAGFSLENGQMRQGGREFGRQAYVGLSKTDLGTVTFGRQYDSVVDFVQPVTAVGQFGGPFVRGGDIDNTDNSFRVDNSIKYASPSFGGFTFGGMYSFTNSNAPGLGTTGMWSLGAAYSHGGFNAGAAYFYAKNPAARFTDGNFIGNTTGAAIGASGPFSYVGAPRNERIMGIGADYAFGSATAGIDYTNTKFDDANGTTSSVTFSNYEVWGQYKVTPAATLGAAYVYTDGKVNYNGARPKYHQVSLMGSYSVSKRTSFYAMAGFQQAAGDAKQADIFDFSIADASTTNRQLMFRLGMLHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UK9</accession>
    <name>Q63UK9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531370.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108207.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1591"/>
    <dbReference type="EnsemblBacteria" id="CAH35590">
        <property type="protein sequence ID" value="CAH35590"/>
        <property type="gene ID" value="BPSL1591"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1591"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3645"/>
    <dbReference type="eggNOG" id="COG1748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PCEAIVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="120"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="40118" checksum="66A4496C0D4D3BFE" modified="2004-10-25" version="1">MKIAIVGAGLIGHTIAHLLRETGDYEVVAFDRDADALAKLANEGIATQRVDSADAAAIREAVKGFDALVNALPYYLAVNVAAAAKAAGVHYFDLTEDVRATSAIRELAEGSNRAFMPQCGLAPGFIGIAAHELVNGFTEVRDVKMRVGALPEYPTNALKYNLTWSVDGLINEYCQPCEAVRDGRRQWVQPLEGLEHFSLDGIEYEAFNTSGGLGTLCETLEGKVETLDYKSVRYPGHRELIQFLLEDLRLATDRDTLKSIMRRAVPSTKQDVVLVFVTVTGVKHGQLVQDVFTRKIFAKEICGMPMSAIQITTAGAMCAVLDLFREKKLPQSGFVRQEQVPLHAFLANRFGKLYEGGTLERMHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UR6</accession>
    <name>Q63UR6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent DNA helicase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108150.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1530"/>
    <dbReference type="EnsemblBacteria" id="CAH35531">
        <property type="protein sequence ID" value="CAH35531"/>
        <property type="gene ID" value="BPSL1530"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1530"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1721"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVTNHAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="686" mass="74503" checksum="20E4AF516D337C3B" modified="2004-10-25" version="1">MARAVAAAMEASGKLMPEPEIFETRKRPARRMQDGAAAGRDDACAAPPGDESADSGDNTLIVEAGTGTGKTYAYLVPAMLWGGKVIVSTGTKHLQDQLFQRDIPTVRDALAVPVTVAMLKGRANYLCHYYLQRTADNGRLPSRQDTAYLQDILRFAKITRSGDKAELASVPETSPVWSMVTSTRDNCLGQECPHYKDCFVMQARREAQQADIVVVNHHLFFADIMLRDTGMAELLPSANTIIFDEAHQLPETATLFFGETLSTTQLLELARDAVAEGLAHARDAVEWVKLGGALERAARDVRLAFADDGIVRMSLAQLGDGHPLFGALDALDAALDALSTALAGQAERAESIAACQRRARELQDLLAGWVAPGAQDGAADAADAKPAAQTGEHGDPAEKVRWVEVFAHTVQLHETPLSVAPIFAKQRAGVPRAWIFTSATLSVRGDFTHYAAQMGLSSRRSMTLPSPFDYQAQGLLYVPRNLPQPSSPAFTDAVFDAALPAIEASGGGVFVLCTTLRAVDRIAMKLRDTIDARGWSTPLLVQGDASRTELLDRFRAYGNAILVGSQSFWEGVDVRGDALSLVVIDKLPFAPPDDPVLAARLDALTKKGLSPFAVHQLPQAVITLKQGAGRLIRAETDRGVLMICDTRLVDKPYGRRIWQSLPPFKRTREIDVVREFFAERREAEQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UU4</accession>
    <name>SURE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">surE</name>
        <name type="ordered locus">BPSL1502</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527164.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108122.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UU4"/>
    <dbReference type="SMR" id="Q63UU4"/>
    <dbReference type="STRING" id="272560.BPSL1502"/>
    <dbReference type="EnsemblBacteria" id="CAH35503">
        <property type="protein sequence ID" value="CAH35503"/>
        <property type="gene ID" value="BPSL1502"/>
    </dbReference>
    <dbReference type="GeneID" id="56529226"/>
    <dbReference type="KEGG" id="bps:BPSL1502"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3538"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235598" description="5'-nucleotidase SurE">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <sequence length="253" mass="26985" checksum="3CFCC204D47F1593" modified="2004-10-25" version="1">MRILLSNDDGYLAPGLAALYEALRPLAEILVMAPEQNCSGASNSLTLSRPLSVSRSAATGFYYVNGTPTDSVHVALTGMLDTKPDLVVSGINNGQNMGDDTLYSGTVAAATEGIMFGVPAIAFSLVHKEWAHLGDAARVAAEIVRHYLDHPLPGQPLLNINIPNLPYEELKGWRVTRLGKRHPSQPVIRQTNPRGEPIYWIGAAGDALDASEGTDFHATASGYVSITPLQLDLTHTQMLAATRDWARAGSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V64</accession>
    <name>Q63V64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531118.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108002.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35377">
        <property type="protein sequence ID" value="CAH35377"/>
        <property type="gene ID" value="BPSL1377"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1377"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.100"/>
    <dbReference type="OMA" id="QDPADYH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="63" mass="6328" checksum="F0F22B78DD9A21FA" modified="2004-10-25" version="1">MTRIVIIALVAAVLAGCASDPRQGRRGTPPQDPPDYQGVPTDMTPPSMLGEPGTGGAAATPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V97</accession>
    <name>Q63V97_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glyoxalase II</fullName>
            <shortName evidence="5">Glx II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gloB</name>
        <name evidence="7" type="ordered locus">BPSL1344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526568.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107969.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1344"/>
    <dbReference type="EnsemblBacteria" id="CAH35342">
        <property type="protein sequence ID" value="CAH35342"/>
        <property type="gene ID" value="BPSL1344"/>
    </dbReference>
    <dbReference type="GeneID" id="56526494"/>
    <dbReference type="KEGG" id="bps:BPSL1344"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.137"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="6">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="29131" checksum="1EAE3C9344A5633A" modified="2004-10-25" version="1">MNELEYVPVPAFDDNYIWLVSDGRQAVAVDPGEAAPVRRHLDARGWRLTAILLTHHHRDHVGGVAELLAGAREGEPIAVFGPAHEAIEHITRRVAGGERVRIGAPALEFDVIDVPGHTRGHIAYFQPAGPGNAAPHLFCGDTLFSCGCGRLFEGTPAQMLASLDALAALPGDTRVHCAHEYTLSNIQFALACEPGNAALAAWRDEARARRARGEPTLPTTIAHECAVNPFLRADSASIRATLEARLHEAAPDRLAAFTLMREWKNRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VJ8</accession>
    <name>Q63VJ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subfamily M24B unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107868.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1247"/>
    <dbReference type="EnsemblBacteria" id="CAH35241">
        <property type="protein sequence ID" value="CAH35241"/>
        <property type="gene ID" value="BPSL1247"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1247"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1378"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPALHVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="7">
        <location>
            <begin position="39"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="6">
        <location>
            <begin position="358"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="8">
        <location>
            <begin position="580"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="629" mass="68779" checksum="749DF3EDAE1214E5" modified="2004-10-25" version="1">MRAFIDINRGGHPMIDRLKYSFTDLARYDASVVDTHAGLSRLIDALQLDALVITSQDEYISEWLPRCNNPRYALSGFDGSVGSGVFLSAAAARRIGVPQFVLFVDGRYHLQAEKQCDPALVQVEKLGLNVAMWPAIGDWLAAHAADIKRAGYDAPRLSVAQRARLLGQTERAGVQWTSLAGREIDGAISLPGWRVERPVFELPRSATGVSIAANVATLNSRISEHLGDPRAKAAFITCAADDLSYLLNSRGYHLPYASSHVGFLFVVGEAVALFLPEGFDRCPVRIDSYSALHVIRNDAAALQRFLAQFDVEYVCYGFEAVNCALPDTVRSVWPDARHVDHNPVEAMRASKTPEVLDQFRDAFARSSEAIAEAMRWAKAGEPGKRHSEHDLARVISEAYGARAAVALSFTTIAANGANSASAHYTAISPDVELTEGELVLLDSGAYFEGGFATDCTRVVLRRTHADTRPQPWQREIYTVALKACIKGLVTRFPQAATGADVDAAVRGVCRAHGYDYNHGTGHGIGIHVHEGGVRFNVGSQYGLVPNAVISVEPGIYLPGKGGVRIENIVVIHPSEREPGMMEFENLVTVGYDWDLIDVDLLTDDERAYLRDYERLCVERGTQVTDCPLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VN1</accession>
    <name>NUOC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoC</name>
        <name type="ordered locus">BPSL1213</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186121.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107835.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VN1"/>
    <dbReference type="SMR" id="Q63VN1"/>
    <dbReference type="STRING" id="272560.BPSL1213"/>
    <dbReference type="EnsemblBacteria" id="CAH35208">
        <property type="protein sequence ID" value="CAH35208"/>
        <property type="gene ID" value="BPSL1213"/>
    </dbReference>
    <dbReference type="GeneID" id="56595147"/>
    <dbReference type="KEGG" id="bps:BPSL1213"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.313"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MERETYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000358071" description="NADH-quinone oxidoreductase subunit C">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <sequence length="200" mass="22765" checksum="86AC4B37D61D73F7" modified="2004-10-25" version="1">MASKIETLKANLEAALGARAVSLVEAVGELTLVVKASDYLEVAKQLRDDRSLGFEQLIDLCGVDYQTYGDGAYDGPRFAAVLHLLSVANNWRLRVRVFASDDDLPIVPSVVDIWNSANWYEREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPVSGYVEMRYDPQEKRVVYQPVTIEPREITPRVIREDRYGGLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX5</accession>
    <name>Q63VX5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase (LPS biosynthesis-related)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185786.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107741.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1120"/>
    <dbReference type="EnsemblBacteria" id="CAH35113">
        <property type="protein sequence ID" value="CAH35113"/>
        <property type="gene ID" value="BPSL1120"/>
    </dbReference>
    <dbReference type="GeneID" id="56595069"/>
    <dbReference type="KEGG" id="bps:BPSL1120"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.428"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PAWKNWP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="381" mass="41445" checksum="4FEB6EB2A403B187" modified="2004-10-25" version="1">MSRLHGRIHIFSRALPRLVLKPLRRKPAHLRRILIAHHLLLGDTLLLTPLVAKLREQHPDAQIVLACPKAIAPLYAKRPFGVDALAFDPRDGVSVRRLLASGPYDLGIVAGDNRHSWLALGAGCRWIVAHAGDAPGWKNWPVDELVPYPEAPAAWADFAAALVDGPAPRLYRPSDWPAPQASAPLPAALRERPYVVLHPGASTAVKRWPSERWRELASLIEAQGYQPVWSGGPSEVEFVAQIGPDSAQPNLAGRLGLADLWHVLAGARAVVCPDTGIAHLARLVGVPTVALFGPGNAGIHGAGRYWRDAPFIALTIADMPCRDQPSMFRRHVAWVRRCDRSAQTCVAWRGDHADCMGRLSVDAVHRALQNVLALAPSSSSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W00</accession>
    <name>TAL_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tal</name>
        <name type="ordered locus">BPSL1095</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533671.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107716.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63W00"/>
    <dbReference type="SMR" id="Q63W00"/>
    <dbReference type="STRING" id="272560.BPSL1095"/>
    <dbReference type="PRIDE" id="Q63W00"/>
    <dbReference type="EnsemblBacteria" id="CAH35088">
        <property type="protein sequence ID" value="CAH35088"/>
        <property type="gene ID" value="BPSL1095"/>
    </dbReference>
    <dbReference type="GeneID" id="56526747"/>
    <dbReference type="KEGG" id="bps:BPSL1095"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.462"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KFGYKTL"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="PTHR10683:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230946" description="Transaldolase">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00492"/>
        </source>
    </evidence>
    <sequence length="317" mass="35373" checksum="F7DC4E0CB742C75B" modified="2004-10-25" version="1">MTTALDQLKQYTTVVADTGDFQQLAQYKPQDATTNPSLILKAVQKDAYRPILEKTVRDHAGESVGFIIDRLLIAFGTEILKLIPGRVSTEVDARLSFDTQRSIDKGREIIKLYEAAGVGRERVLIKLASTWEGIRAAEVLQREGIRCNMTLLFSLVQAAACAEAGAQLISPFVGRIYDWYKKQKGADWDEAQDGGANDPGVQSVRRIYTYYKHFGYRTEVMGASFRTTSQITELAGCDLLTISPELLQKLHDSTEAVARKLSPDEARDARLERVAIDESSFRFQLNDDAMATEKLAEGIRLFSADAVKLEKMIEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W51</accession>
    <name>Q63W51_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL1038a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107665.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1038a"/>
    <dbReference type="EnsemblBacteria" id="CAH35034">
        <property type="protein sequence ID" value="CAH35034"/>
        <property type="gene ID" value="BPSL1038a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1038a"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1128"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="91" mass="9927" checksum="EB37E27EDA087D80" modified="2004-10-25" version="1">MTASAAKPPRSPGSRRFAREAGSARPRDGTTLLHPVFQAQPCGRRTMEILPGRKRIGPATGGRRADQREVACAGWPLLRRNVELCRDPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WI5</accession>
    <name>Q63WI5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">dfp</name>
        <name evidence="3" type="synonym">coaBC</name>
        <name evidence="7" type="ordered locus">BPSL0904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186216.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107531.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0904"/>
    <dbReference type="EnsemblBacteria" id="CAH34898">
        <property type="protein sequence ID" value="CAH34898"/>
        <property type="gene ID" value="BPSL0904"/>
    </dbReference>
    <dbReference type="GeneID" id="56594760"/>
    <dbReference type="KEGG" id="bps:BPSL0904"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.678"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="188"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="403" mass="43180" checksum="375F0E952CF7143C" modified="2004-10-25" version="1">MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSGRPVYTSQWDARMPNNMAHIDLSREADAIVIAPASTDFLAKLAHGFADDLLSTLCIARDCPLLVVPAMNRQMWQNPATQRNVAQLRHDGVAVLGPDSGAQACGEVGDGRMLEPEAIYEAIVTHFQPKALAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGADVHLVAGPVHLPTPWGVYREDVQTAQQMYDAVMNAVPDADVFIAVAAVADWRAAQPAEHKIKKTADHKMPALTFVENPDILASVAALPDAPYCVGFAAESGDLDVHGEEKRVRKRVPLLIGNLGPLTFGLDDNEVVLFEASGTTRLPRADKMTLAHALVAEIAKRLPDTRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WP0</accession>
    <name>Q63WP0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ordered locus">BPSL0851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189960.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107476.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0851"/>
    <dbReference type="EnsemblBacteria" id="CAH34843">
        <property type="protein sequence ID" value="CAH34843"/>
        <property type="gene ID" value="BPSL0851"/>
    </dbReference>
    <dbReference type="GeneID" id="56596511"/>
    <dbReference type="KEGG" id="bps:BPSL0851"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.748"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYCAFVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20522" checksum="C6F27BAD1204484C" modified="2004-10-25" version="1">MSEATSEVATLGGGCFWCQEAVFLDVDGVTAVESGYAGGHTRNPGYRDVCDGDTGHAEVVSVSFDPARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVIFTHSDAQRDAALELIRTLERDKLYDDPIVTQVEPLNGNYWPAEAYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WQ0</accession>
    <name>Q63WQ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550800.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107466.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0842"/>
    <dbReference type="EnsemblBacteria" id="CAH34833">
        <property type="protein sequence ID" value="CAH34833"/>
        <property type="gene ID" value="BPSL0842"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0842"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.759"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFRHEEP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="202"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="394"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="539" mass="57270" checksum="019F1DDB5EF4FF9F" modified="2004-10-25" version="1">MTPPDLRADAPARAPYTVRDAVIDLLRRFGIRKVFGNPGSTELPMFRNFPDDFEYVLGLHEAVAVGMADGYVQASGNAAVVNLHSAAGVGNAMGVLFTAYRNKTPLVVTAGQQARSILPFEPFLASVQAAELPKPYVKWSIEPARAEDVPAAIARAYHVAMQEPRGPVFVSIPADDWDRPAEPMPARTVSSEVRPAPEALARLGDALDASERPAFVVGAAVARAGAWDDAVRLAERHRARVYAAPMSGRCSFPEDHPLFAGFLPPIRERIVEQLAGHDFILAFGAPVFTYHIEGFGPHVPAGAALHQLVDDPSVAAWTPVGDAVVGNLRLAARDLLARAAPRERPMPAPRAPRGRVGPGAPGERMPVAFALQTLADVRGSRDVVVEEAPSARPAMHEHLPFSSADTFYTMDSGGLGYGMPAALGIALGSPGRRVIALIGDGSSLYSIQALWSAVHLKLPVTFVILNNARYAALQDFAPVFGFRDGEPVQGTALPGLDFVSLARGFGCDGVRVSDAARLRDALEQALASPVPVVVDVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WQ7</accession>
    <name>Q63WQ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189067.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107459.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0835"/>
    <dbReference type="EnsemblBacteria" id="CAH34826">
        <property type="protein sequence ID" value="CAH34826"/>
        <property type="gene ID" value="BPSL0835"/>
    </dbReference>
    <dbReference type="GeneID" id="56596527"/>
    <dbReference type="KEGG" id="bps:BPSL0835"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.766"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEANCFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="32536" checksum="741CD14F09A6015D" modified="2004-10-25" version="1">MESLSGFVVFVQVAETRSFVAAARALGVSASAVGKRIARLEARLNVRLFHRSTRSIALTAEGARFLERCRRVLAEIEEAEQELSRSAHAPSGRLRVSLPALSAPVLPVLADFMAAYPDIQLDLDFTDRLVDVIDEGFDAVVRGGEPRDSRLSARRLGTFAQVVVGSPDYFARRGTPRTPADLAHHTCLLYRFPTTGKLERWPLRPAPGDADVEPPRSMICNNVETRVCFAIRGRGLACVPDFAVRDELASARLRTVLDAYIERPQTFHVLWPSGRHASPKLRAFVDFIVGRMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WR2</accession>
    <name>Q63WR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transmembrane ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550807.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107454.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0830"/>
    <dbReference type="EnsemblBacteria" id="CAH34821">
        <property type="protein sequence ID" value="CAH34821"/>
        <property type="gene ID" value="BPSL0830"/>
    </dbReference>
    <dbReference type="GeneID" id="56526991"/>
    <dbReference type="KEGG" id="bps:BPSL0830"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.771"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKIVYFF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="314" mass="34391" checksum="44E9962BBD319C83" modified="2004-10-25" version="1">MRHLRLPLAHSASLVGAGPAADERARGKPARWLAAPSVAVLLLWMAIPLAMTIWFSLTRYNLLNPDVKGFAGLENYRFLATDPSFLPAIWHTLALIGSVLAITVAGGVLMAVLFDRKFYGQGIARLIAIAPFFVMPTVSALIWKNMILHPVYGLVARAMRALGMQPIDWFAQYPLTSIVIIVAWQWLPFAFLILFTAIQSLDQEQKEAARIDGAGAFAMFFYITLPHLRRAIAVVVMMETIFLLSIFAEIYTTTGGGPGDATTNLSYLIYALGLQQFDVGLASAGGILAVVLANVVSFFLVRMLARNLKGEYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WY4</accession>
    <name>Q63WY4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204884.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107382.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0757"/>
    <dbReference type="EnsemblBacteria" id="CAH34749">
        <property type="protein sequence ID" value="CAH34749"/>
        <property type="gene ID" value="BPSL0757"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0757"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="147" mass="15987" checksum="7BCACCFD270945AA" modified="2004-10-25" version="1">MECSGVSAGDASHSVSQLPLPVRVSDVAWFYVRYDDEDGSETPGTAYVVHTYSGARKLIASTRGRQPVLYLCLAKRVGDISLRRVVAVRDAPDTSLQVLELEDGRAVMLDLSRDGEGDFAYLEIDLPLCTSQLEVTELVAPNARAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X13</accession>
    <name>Q63X13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936452.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107353.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0727"/>
    <dbReference type="EnsemblBacteria" id="CAH34719">
        <property type="protein sequence ID" value="CAH34719"/>
        <property type="gene ID" value="BPSL0727"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0727"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.883"/>
    <dbReference type="eggNOG" id="ENOG5032RMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSHPWAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="30049" checksum="6A82944810965FB6" modified="2004-10-25" version="1">MKTRTNRPGGGVLARGRYAGYDVLAKRDTPSWNDATRRVLDARLAPREAPRYLDARQFATLDAVCARIVAQSEPRDARQADAEADAAAEAEVETATEAAAAAETAANEGASTRAPIPVAALIDERLLHDEGDGYRDARMPSYREAWRIGLAALDAHARAEHGRPFASLAGAERDAILRAAQRGALDGPAWRGMSSALFFSKRVLSDVASAYYSHPLAWNEIGFGGPASPRGYVRMDFNRRDPWEAPLAARDDGRADADAASPRRLAQPGKRKGNRDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XC2</accession>
    <name>Q63XC2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522821.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107243.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0614"/>
    <dbReference type="EnsemblBacteria" id="CAH34607">
        <property type="protein sequence ID" value="CAH34607"/>
        <property type="gene ID" value="BPSL0614"/>
    </dbReference>
    <dbReference type="GeneID" id="56527176"/>
    <dbReference type="KEGG" id="bps:BPSL0614"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1013"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CASTAMI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="255"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="44211" checksum="44A966CA767A7A74" modified="2004-10-25" version="1">MKRFDAETGNARVAAVESLLADDHTLNEAARRVAQVAARFADAVDRDARFPTEAVDAMREERLLGALVPIELGGRGASLAAVAAACRIIGQACSSAAMIYAMHQTQVASIVDHALSSDWHRRFAEQLAEREWLLASATSEEEVGGNLRNSRCAIEADGDMFTLAKLAPTISYGAQADAILVTARRDRDAPAAEQVLVTLLKENATLTRRSGWDTFGMRGTCSEGFALDARGYCEQIFPVPFAQIAERTMVPTSHILWAAVWTGIANDAFLRAHQFFRAQMQKQGGALPPSGRRIADALALLQAMQARIDGALRLHEHSASRSWSATMAQAAEINTLKTYVSTTALEVVKHATMICGMASYKNGTPYTLGRHIRDLHSAPLMISNDRIEANTANLLLALRPATLEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XE8</accession>
    <name>Q63XE8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107217.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0588"/>
    <dbReference type="EnsemblBacteria" id="CAH34581">
        <property type="protein sequence ID" value="CAH34581"/>
        <property type="gene ID" value="BPSL0588"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0588"/>
    <dbReference type="eggNOG" id="ENOG5032YM6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AIFAWIN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="188" mass="21972" checksum="5569A00E864C32CE" modified="2004-10-25" version="1">MLVALLSIISAAIFAWINYQRERLNQRIHYVNLRQQHFLALRVWSDQISDLFSEVIHFCELDPEKCPSGSFFERRNKYRIALSSMIDRGRWFFPNLNTESHGQGKELAFRGYRQDVLNSLVDAYNSVTDINYVTRCRNDDLKKRIVTAKKRFVSEIQSILDPVQLDQEFIDITTHVTGVDRQGKSNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XE9</accession>
    <name>Q63XE9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552423.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107216.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34580">
        <property type="protein sequence ID" value="CAH34580"/>
        <property type="gene ID" value="BPSL0587"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0587"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1053"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IWAIRVR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="208" mass="23940" checksum="A40C07A9EBC07008" modified="2004-10-25" version="1">MESENVVVVYRVPWNQGKLIGQKPPLKLREIWAIRTRLQVASNVRELAMFNLAIDSKLRACDLTRLRVQDVRHGSQVASRATVMQQKTQRPVQFEITEQTRESLEAWIDARGLKAADFLFPSRIHTSQHLSTRQYARLVQRWVASIGLDDTAYGTHTMRRTKASLIYRQTKNLRAVQLLLGHTKLESTVRYLGIEVDDALEMAEQTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XV9</accession>
    <name>Q63XV9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936133.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107056.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0431"/>
    <dbReference type="EnsemblBacteria" id="CAH34419">
        <property type="protein sequence ID" value="CAH34419"/>
        <property type="gene ID" value="BPSL0431"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0431"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1229"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWTIRPP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17346" checksum="D21F8532DEA49139" modified="2004-10-25" version="1">MTIVVRAARRTDWPTLRSLYLHARRDTFAWLPAERFAAGDFDEHTRGEALLVAQARDEGIVGFVSVWEPERFVHHLYVAGTRLREGIGAALLRALPGWPAARYRLKCLVRNERALAFYRAHGFVEIDSGVSADGEYRLLGTREAATAARPGKRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y24</accession>
    <name>BIOD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="1">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DTB synthetase</fullName>
            <shortName evidence="1">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioD</name>
        <name type="ordered locus">BPSL0365</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530983.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106991.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Y24"/>
    <dbReference type="SMR" id="Q63Y24"/>
    <dbReference type="STRING" id="272560.BPSL0365"/>
    <dbReference type="EnsemblBacteria" id="CAH34353">
        <property type="protein sequence ID" value="CAH34353"/>
        <property type="gene ID" value="BPSL0365"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0365"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1305"/>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SPHWAAE"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000302490" description="ATP-dependent dethiobiotin synthetase BioD">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <sequence length="240" mass="24922" checksum="0E28F2356909D720" modified="2004-10-25" version="1">MSAPLSLFVTGTDTEIGKTFVSAALLHGFARAGLRAAAMKPVAAGAYERDGAWRNEDADQLDAAANVALPAAIRTPFLLKAPAAPHIVAAREGVALDIGTIVDAHRRACEMADVIVVEGVGGFRVPLADTRDTADLAVALGLPVVLVVGVRLGCISHALLTAEAIAARGLPLAGWVANRIDPAMPFADDNIDTLRAWLEREHRAPLLGALAHMSPPSPDAASHALDVNLLLNALRAAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y67</accession>
    <name>Q63Y67_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204787.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106948.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0321"/>
    <dbReference type="EnsemblBacteria" id="CAH34310">
        <property type="protein sequence ID" value="CAH34310"/>
        <property type="gene ID" value="BPSL0321"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0321"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1365"/>
    <dbReference type="eggNOG" id="COG2942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVQAETF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00249">
        <property type="entry name" value="AGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034116">
        <property type="entry name" value="AGE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="485" mass="54437" checksum="3E702B1BAC5073FD" modified="2004-10-25" version="1">MTTSASPAPRPAPAAPPAAAPYVASFRDPQFLLAHVEDTLRFYAPHAFDPTGGFYHFFRDDGSVYDRTTRHLVSSCRFVFNHAMAYRHFGDARDLDYARHGLRFLRDAHWDAEHEGYDWEIEWRDGAKRATRDGTRHCYGLAFVLLAAAHAAMAGVEEAKPLIAHTFDLMEHRFWDRAAGLYADDATPNWTVSSYRGQNANMHATEALLAAYEATGHLTYLDRAEKIATNIVQRQAALSQGLVWEHFHADWSVDWEYNKEDSSNIFRPWGFQPGHQTEWAKLLLILERHRPLDWLVPRAIELFDAAFAHAWDSDHGGLCYGFGPDYTVCDHDKYFWVQAESFAAAALLAQRTGSERFWDWYDEIWRYSWAHFVDHRHGAWYRILTCDNRKYSDEKSPAGKTDYHTMGACYEVLHTLASTRDDSGRGANAGGGAGDDDRAPRAAHDNGRGGGGKGGGKSGGTDDHGHRGEGDAADGAGRRRNGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YA7</accession>
    <name>Q63YA7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flagellar hook-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200262.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106908.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0281"/>
    <dbReference type="EnsemblBacteria" id="CAH34269">
        <property type="protein sequence ID" value="CAH34269"/>
        <property type="gene ID" value="BPSL0281"/>
    </dbReference>
    <dbReference type="GeneID" id="56594368"/>
    <dbReference type="KEGG" id="bps:BPSL0281"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1424"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRVTQGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="42096" checksum="A16CEEE9CDA021D9" modified="2004-10-25" version="1">MRISSTQLYSLNVDMMNDQQAQIAQLYQQVSSGISLTTPADNPLAAAQAVQLSATSATLAQYTQNQTIVQTALQTEDTTLTSVNDVLNAAYQALMHAGDGGLSDSDRAALAAQIQGSRDHLLTLANTADGAGNYLFAGFQPTTQPFSNKPGGGVTYAGDYGARAVQIADTRTVSQGDNGANVFMSVPFLGSLPVPAAGASNTGTGTIGAVSITNPSDPTNTHQFTITFGGTAAAPTYTVTDNSVTPPTTTAAQAYSSGQGINLGGQTVAVSGKPAVGDTFTVTPAPQAGTDVFATLDTVIAALKSPVGNSQTASTALTNTMATASTKLMNTMTNVLTVQASVGGRLQEVKAMQAVTTTNTLQTTNSLSNLTDTNLPAAISQFLQLQNSLSAAQKAFVQMQNLSLFQYLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YH2</accession>
    <name>Q63YH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106843.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0214"/>
    <dbReference type="EnsemblBacteria" id="CAH34202">
        <property type="protein sequence ID" value="CAH34202"/>
        <property type="gene ID" value="BPSL0214"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0214"/>
    <dbReference type="OMA" id="LIEWNDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="84" mass="9153" checksum="695F1BB2620C11A5" modified="2004-10-25" version="1">MRQRLPLGIDSPISPTSVATTPPAISMIVFVEGEPVKKRATPSLIEWNDWPPKYSSTTPPTMSATEIARVMKILAETDDEDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM0</accession>
    <name>Q63YM0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552636.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106795.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0167"/>
    <dbReference type="EnsemblBacteria" id="CAH34154">
        <property type="protein sequence ID" value="CAH34154"/>
        <property type="gene ID" value="BPSL0167"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0167"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1555"/>
    <dbReference type="eggNOG" id="ENOG5030XG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="9220" checksum="4E6BDFB65D99224A" modified="2004-10-25" version="1">MARPLYRIRQFAQSRVRGGKLFCAGACQVQQRVAGLFWLEIAYCSDRTGAEAAIRAAVIARRRARLKPRVLGLFGRDGQALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM2</accession>
    <name>Q63YM2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative phage-encoded membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0165</name>
        <name evidence="3" type="ordered locus">BPSS1070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524439.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106793.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111081.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0165"/>
    <dbReference type="EnsemblBacteria" id="CAH34152">
        <property type="protein sequence ID" value="CAH34152"/>
        <property type="gene ID" value="BPSL0165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38536">
        <property type="protein sequence ID" value="CAH38536"/>
        <property type="gene ID" value="BPSS1070"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0165"/>
    <dbReference type="KEGG" id="bps:BPSS1070"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1557"/>
    <dbReference type="eggNOG" id="ENOG5032YF4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFINGNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032637">
        <property type="entry name" value="Phage_holin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16931">
        <property type="entry name" value="Phage_holin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="114" mass="11489" checksum="DC6C3E2BF17E7779" modified="2004-10-25" version="1">MAEPNTSSAAALFAAVGLAGIAPGVDGDALIGAFAGAALVVVTSKDLGLAKRAAYMLISLVMGYLAAPEIIHAVPIRSTGVAAFFAAALVIAVTLTLIERVKGMDLFALFRKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YY0</accession>
    <name>Q63YY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106685.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0060"/>
    <dbReference type="EnsemblBacteria" id="CAH34043">
        <property type="protein sequence ID" value="CAH34043"/>
        <property type="gene ID" value="BPSL0060"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0060"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1681"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QAKDFFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="364" mass="38339" checksum="8BFEE046D7059501" modified="2004-10-25" version="1">MKKPLRGTGRPGVAILLPPRLLGGYVFLTQELLLLAGTMKARSLDVVNSRLFDIAILSHDGRPVPTIGGLDVPATAALSDADAHEVVIVPAQFMPDAQIGALERVFIDWLERRYAAGALVVGLNAAPLLAKAGLLDGRGATGLPSERTLFARHFPAVRYTPSKPLVVDGRLITVSGINPAVDACAYVIDYCFGAGVSQRLLRVALTQSLPSYEHMAVWAAQYKRHGDAPVLAVQDSVERALAHPPTLAELAARAAMSERTLSRRFAAATGLTLRRYVAALRVELAAFLLRTSRMTLEHIADECGFASASALSHAFLAGQGCSPIQYRNRHRPDARREPAGGGGTGGTAAGSGEGAASSGGRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YY9</accession>
    <name>Q63YY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phenylacetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.39" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536404.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106676.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0051"/>
    <dbReference type="EnsemblBacteria" id="CAH34034">
        <property type="protein sequence ID" value="CAH34034"/>
        <property type="gene ID" value="BPSL0051"/>
    </dbReference>
    <dbReference type="GeneID" id="56527671"/>
    <dbReference type="KEGG" id="bps:BPSL0051"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1692"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PAAWMNN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008957">
        <property type="term" value="F:phenylacetaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="39"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="501" mass="53179" checksum="9B9731725839E4C8" modified="2004-10-25" version="1">MNLAALSTQHQRQSGFLARRQFGNWIDGRAAEPRSGCYLPVVDPATEMTIAEVAASDARDVDAAVAAARRAFDSGDWPRMRPASREKLLHQLAERLERYADELAALETLETGKLIGVARAIDVLGGAEYVRYMAGWATKLEGSTLDTSIAAPAGAEYFAYTRREAVGVVGAIVPWNFPLAIALWKVATALACGCTVVLKPSEETPLTALRLGELAQEAGLPDGVLNIVTGAGAEAGAALAAHPGIDKITFTGSVGVGRAIGHAAVERMARFTLELGGKSPLIVLDDADPDFAAHGAAQGIFFNQGQVCTAGSRVYVQKRLFERVVAGIAAAAEAMKIGSGFDPNTQIGPLVSKRHFERVLGHVDAAKEEGATLVTGGTRALDGGYFVKPTVFVDAAPAMRIVREEVFGPVVTVTPFDTVDDAVRLANDTDFGLAASVWSQNLSHVHRVVPRLKAGIVWVNTHNMLDPNLPFGGFKQSGYGRELGRAALEQFTELKSVCIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>H7C729</accession>
    <name>H7C729_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">fur</name>
        <name evidence="5" type="ordered locus">BPSL2943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194273.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109537.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2943"/>
    <dbReference type="EnsemblBacteria" id="CAH36953">
        <property type="protein sequence ID" value="CAH36953"/>
        <property type="gene ID" value="BPSL2943"/>
    </dbReference>
    <dbReference type="GeneID" id="56593781"/>
    <dbReference type="KEGG" id="bps:BPSL2943"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2337"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLYGVCT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="142" mass="16291" checksum="05DE8CD6797B3BFC" modified="2012-04-18" version="1">MTNPTDLKNIGLKATLPRLKILEIFQQSPVRHLTAEDVYRNLLHEELDIGLATVYRVLTQFEQAGLLSRSNFESGKAVFELNEGSHHDHLVCLDCGRVEEFFDAEIETRQQSIAKERGFKLQEHSLAMYGTCTTENCPYRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>H7C731</accession>
    <name>H7C731_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-oxoadipyl-CoA thiolase</fullName>
            <ecNumber evidence="4">2.3.1.174</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcaF</name>
        <name evidence="10" type="ordered locus">BPSS0275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:19481"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57348"/>
            <dbReference type="EC" id="2.3.1.174"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522007.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110295.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0275"/>
    <dbReference type="EnsemblBacteria" id="CAH37722">
        <property type="protein sequence ID" value="CAH37722"/>
        <property type="gene ID" value="BPSS0275"/>
    </dbReference>
    <dbReference type="GeneID" id="56597099"/>
    <dbReference type="KEGG" id="bps:BPSS0275"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6368"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NASPMND"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012793">
        <property type="entry name" value="PcaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02430">
        <property type="entry name" value="pcaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="9">
        <location>
            <begin position="277"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="41692" checksum="0B23848BA8668FCE" modified="2012-04-18" version="1">MTEAFLCDAIRTPIGRYGGALAPVRADDLGAVPLKALVERNRDVDWAAVDDVIYGCANQAGEDNRNVARMSLLLAGLPHAVPGATINRLCGSGMDAIGLAARAIKAGEASLMIAGGVESMSRAPFVTGKATSAFSRQAEIFDTTIGWRFVNPLMKQRYGVDSMPETAENVATDYRVSRADQDAFALRSQQKAARAQADGTLAQEIAPVTIAQKQGEPLVVARDEHPRETTLEALAKLKGVVRPDGTVTAGNASGVNDGACALLVASEAAARRHGLVPRARVLGIATAGVEPRVMGIGPAPATQKLLARLGMTLDQFDVIELNEAFASQGLAVLRLLGVADDDARVNPNGGAIALGHPLGASGARLVTTATYQLHRTGGRFALCTMCIGVGQGIAIAIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H7C732</accession>
    <name>H7C732_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative general secretory pathway protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gspC</name>
        <name evidence="1" type="ordered locus">BPSL0010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196816.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106635.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0010"/>
    <dbReference type="EnsemblBacteria" id="CAH33993">
        <property type="protein sequence ID" value="CAH33993"/>
        <property type="gene ID" value="BPSL0010"/>
    </dbReference>
    <dbReference type="GeneID" id="56594179"/>
    <dbReference type="KEGG" id="bps:BPSL0010"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1738"/>
    <dbReference type="eggNOG" id="ENOG5032UKC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CATLTYW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="136" mass="14164" checksum="0F5556CD72F40DE2" modified="2012-04-18" version="1">MNALSIRILSLALFAVLCATATYWVVTLSAHQAPLPAAAARTPVRTEDAAALFGGQLTRSPVQDIHLFGILALQRGAAAIVGIGGDAPHAVSLGSEIAQGAKLAEVRDRSIIVERNGARSEIFLPANTPSPAIYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>H7C740</accession>
    <name>H7C740_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wbiB</name>
        <name evidence="2" type="ordered locus">BPSL2679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205203.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109275.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2679"/>
    <dbReference type="EnsemblBacteria" id="CAH36687">
        <property type="protein sequence ID" value="CAH36687"/>
        <property type="gene ID" value="BPSL2679"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2679"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2663"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPRMPRD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="363" mass="39147" checksum="41EB7011FC56E2B4" modified="2012-04-18" version="1">MSDVNASLVDGKKILVTGGAGFIGCAISERLAARASRYVVMDNLHPQIHASAVRPGALHEKAELVVADVTDAGAWDALLSDFQPEIIIHLAAETGTGQSLTEASRHALVNVVGTTRLTDALVKHGIVVEHILLTSSRAVYGEGAWQKDDGTIVYPGQRGRAQLEAAQWDFPGMTMLPSRADRTEPRPTSVYGATKLAQEHVLRAWSLATKTPLSILRLQNVYGPGQSLTNSYTGIVALFSRLAREKKVIPLYEDGNVTRDFVSIDDVADAIVATLARTPEALSLFDIGSGQATSILDMARIIAAHYGAPEPQINGAFRDGDVRHAACDLSESLANLGWKPQWSLKRGIGELQTWIAQELDRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HY5</accession>
    <name>Q63HY5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530666.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112287.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2284"/>
    <dbReference type="EnsemblBacteria" id="CAH39770">
        <property type="protein sequence ID" value="CAH39770"/>
        <property type="gene ID" value="BPSS2284"/>
    </dbReference>
    <dbReference type="GeneID" id="56531625"/>
    <dbReference type="KEGG" id="bps:BPSS2284"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5903"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHNTQCW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="37037" checksum="D2391D16284362B4" modified="2004-10-25" version="1">METSPLKTTTPEAIPPFDPSASVEDKLRLAIHYAILAPSSHNTQPWRFMVGDGSVMLCADRLRALSVVDPYDRELLISCGAALLNLRVALSRFGLAYVIDMFPSPSDPDVIALVRLDPHGYHDESLVPLFDAILERVTTRTPYANEAVPCDVQRALVDAGAAEGAEIACVDAPHALDEIAELIADADRLQFADPRFRRELANWVHPRRHDDGMPAFAAGVPALLDFATPVVASAIRTFDLGGGLAAMHHKLVDGSPLIVGISTASDDRDAWVAAGQALERVLLVAAAAGLTASYLNQPIEIDALRERLRPLLHVDAHPQLLLRIGRGPVVAHAPRRPLMDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ2</accession>
    <name>Q63IJ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555373.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112080.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2079"/>
    <dbReference type="EnsemblBacteria" id="CAH39559">
        <property type="protein sequence ID" value="CAH39559"/>
        <property type="gene ID" value="BPSS2079"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2079"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MEHGVNP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="14624" checksum="2A8F7B7635ACAF99" modified="2004-10-25" version="1">MGTKVATDTPKRTSRKGIPNHPIEFRRHLAKLACEPDISVARLAMEHGVNPNRVFKWRRALRAGEYDPVDLLPVTVEAPAQEIEQPAPAPVARAAPAGAIEISVGNTRVRIEGSPHEATLLLVLRMLRGTSGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IL9</accession>
    <name>Q63IL9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941129.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112053.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39529">
        <property type="protein sequence ID" value="CAH39529"/>
        <property type="gene ID" value="BPSS2051"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2051"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5587"/>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HHERHIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008008">
        <property type="entry name" value="DUF746"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05344">
        <property type="entry name" value="DUF746"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF746" evidence="1">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF746" evidence="1">
        <location>
            <begin position="242"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="379" mass="42802" checksum="E526E1139C242B41" modified="2004-10-25" version="1">MATKGQSHTRLPAVGPDTEQDRGLTAFLTAQIAPLLSESHELRPRFPRCGSRHINSAGFRTRPIGRLPMFECQMCRRYFSRTAGTPLGEKHLKKLDLFVFLLSQPISCLEAGKQMGSLPDDIGQRVKVWRAWLLQLDPSGQWERRVRLGGRPTELNPAPLAFDEIGAREDRALTARLTCEFDDVNSLSQQPPACPDCGGRNTRFDECPNGAFPRFMCLRCRRRFTRRRGTPFLNTKMSSLERMRLFIRHLSLPLSVMQAADLVGTSHGIIHKWLRMFIEFADQLEPSGSLSARIQLGVEPTETTPCPFCGRAGSAWQTERGHWTCAGCGRLFSMRRTVVERNGVLEIVDESMAGDEELITSQRTIARDDRHDSEYGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IM6</accession>
    <name>Q63IM6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529289.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112046.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2043"/>
    <dbReference type="EnsemblBacteria" id="CAH39521">
        <property type="protein sequence ID" value="CAH39521"/>
        <property type="gene ID" value="BPSS2043"/>
    </dbReference>
    <dbReference type="GeneID" id="56531837"/>
    <dbReference type="KEGG" id="bps:BPSS2043"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5575"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CGYATIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="139" mass="15178" checksum="9450F2E0876316DB" modified="2004-10-25" version="1">MQENLDADYFNRFGADYLPGLLGVVVKQVEKNHVLAELTIRQAVLAHGILHAGTIVSLADTACGYGCLASLPEGASSFSTLELKSNFMGTARDGVIVCDARAIHSGRTTQVWDATVRHRETDKLLATFRCTQMILWPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IM9</accession>
    <name>Q63IM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative inner membrane fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS2040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529286.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112043.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2040"/>
    <dbReference type="EnsemblBacteria" id="CAH39518">
        <property type="protein sequence ID" value="CAH39518"/>
        <property type="gene ID" value="BPSS2040"/>
    </dbReference>
    <dbReference type="GeneID" id="56531840"/>
    <dbReference type="KEGG" id="bps:BPSS2040"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5572"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CQHGPID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="85"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="346" mass="37488" checksum="FE10CEF1AA09A5F6" modified="2004-10-25" version="1">MKHASAESPDSAGCAETPARAPAGSAADTAAPPAPDERASGHLSRASSARHLGVAALPAAGTAAAIALWAGFGLAPRVQDIAMLAVFYVLNILGMELALHRYFAHRTFKAKPAVKIALAILGSLAYMGPLMWWVAIHRLHHANADRPGDPHTPQLGGRGFAGRAKGILHGHVGWLFDPSSARPKGWNQYANDMYRDPTLLRIHLAYDYWLLLGLLLPGALGWLLDPSWRGALLGLLWGGTVRIFLATNAIWAVNSIGHALGGRRPFPGRDQSRNAAWLALVTLGAGWHNNHHAFPQYASTRLTRWQIDVTGMLIALLERLGLVWDVQHPDRDAVRERLANARRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IQ6</accession>
    <name>Q63IQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552147.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112016.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2013"/>
    <dbReference type="TCDB" id="1.B.95.2.3">
        <property type="family name" value="the outer membrane protein yaio (yaio) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39491">
        <property type="protein sequence ID" value="CAH39491"/>
        <property type="gene ID" value="BPSS2013"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2013"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5531"/>
    <dbReference type="eggNOG" id="ENOG5033155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIFEAGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030887">
        <property type="entry name" value="OMP_YaiO_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19413">
        <property type="entry name" value="YaiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04390">
        <property type="entry name" value="OMP_YaiO_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266476" evidence="1">
        <location>
            <begin position="33"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="YaiO" evidence="2">
        <location>
            <begin position="187"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="418" mass="44374" checksum="61888A609D768250" modified="2004-10-25" version="1">MHAFRCRRGPPVPLAIVALACACVFGAPRARAAAAHADAPVAASIASFEPAGGPAAAADAADTAVMPAPPASFAPPAAPPVPQVASLASSASTVPTTPTATTAPIASAPAATPLSAPPLAPPAAAPPAAAPLVIVPRRFDDTALVKVDSEGMPDGWSLAEVAPNQENQPALPEALVAHVQAPAQRHTELSLAYSMAHLTNGYGDWYGVHLRGLYQAGGRTIIGELAQLHRFNESTQLGAITYIQDMGPDWFGGIGFSGTTSGTILPSARVDLSLNRKLLSNRSLVLSAGAGYAWNRNGHRDQLYHLGAIWYAVPKWIFEAGWNYTVDSPGSVKAPAYYGAITYGEVGKSLIVLRGSFGREAYQATGNNAQITDFRSHEVSLKWRYWVTRKWGTQVEFDYYHNPYYLRIGGEVGMFYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IS8</accession>
    <name>Q63IS8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111994.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1988"/>
    <dbReference type="EnsemblBacteria" id="CAH39466">
        <property type="protein sequence ID" value="CAH39466"/>
        <property type="gene ID" value="BPSS1988"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1988"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6362"/>
    <dbReference type="eggNOG" id="ENOG50339B4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFKINTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="36309" checksum="70F0A7CABE8C7A3C" modified="2004-10-25" version="1">MNGGQRRTPAMPGAPTTLPFDRKGAHMSSLYSIRPDSGSEKVALERVWDGNSPLASGYTSFVALPRAGGPDLIAYNKATQKTDVYALGDAAPWISPVDSKIELAGGPWDSVASFVLGNVRYLLTYRADDGTFGFFALGADRSASPPYKFALPRNTPTRDFTNVAPFTSLGQQYILGYDFDTGRVANFSVAVTPSSAGGAPPLLALNVWYHEWAKGWTQFSFFQLGGANFFFKINTAKLNVNIDHIQDNPALGTVEVGSYLQDQLPDALKITNAACVPWAHGEPTLVTYIAASGATAVYRIHADCLGWTRIGTATTSAGASHVVPYRVGDQSYALFYQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IT3</accession>
    <name>DNS2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>Putative deoxyribonuclease-2</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Deoxyribonuclease II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">BPSS1983</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Gene" volume="305" first="1" last="12">
            <title>A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei.</title>
            <authorList>
                <person name="MacLea K.S."/>
                <person name="Krieser R.J."/>
                <person name="Eastman A."/>
            </authorList>
            <dbReference type="PubMed" id="12594037"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(02)01233-7"/>
        </citation>
        <scope>DISCUSSION OF SEQUENCE</scope>
    </reference>
    <comment type="miscellaneous">
        <text>Unlike their eukaryotic orthologs the putative Burkholderia deoxyribonuclease-2 are probably not secreted from the cell, as they do not have a signal sequence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524950.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111989.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63IT3"/>
    <dbReference type="SMR" id="Q63IT3"/>
    <dbReference type="STRING" id="272560.BPSS1983"/>
    <dbReference type="EnsemblBacteria" id="CAH39461">
        <property type="protein sequence ID" value="CAH39461"/>
        <property type="gene ID" value="BPSS1983"/>
    </dbReference>
    <dbReference type="GeneID" id="56531902"/>
    <dbReference type="KEGG" id="bps:BPSS1983"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5488"/>
    <dbReference type="OMA" id="ILYNDQK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="PTHR10858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230669" description="Putative deoxyribonuclease-2">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="350" mass="38837" checksum="4B5B6D59757B1B53" modified="2004-10-25" version="1">MTISPRDEQNRSVDLWFAYKVPKLTKDTDSDSATGYEYVYYDREIGSVQKSPNRMNNPKGALFYTLDSIFGDPGSTTGWILYNDEMPADADRSNNATLGHTKGVIAFDIASNSALWLLHSWPKYTSPSAPGVPTPLYGQTFLCVSLDLETAGKIAAQMALHQQPQVYLPRTAGLDHASPLYTLTQPLNASAPGDSDSLDFKTRGGAPFKVIAKNRKWGKDFWNDLVGPTLKADMDVETWIRGKIPPILDSDGVHKTYDIKFIDLRKLGAPWAWPETQDHAKWGITTTDDWVCVGDINRMVTQEKRGGGTIAFQDPQLWKALSQTDLIVPPPGKTEAQARAMIHRTHQPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX3</accession>
    <name>Q63IX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009972310.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111949.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39421">
        <property type="protein sequence ID" value="CAH39421"/>
        <property type="gene ID" value="BPSS1943"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1943"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6303"/>
    <dbReference type="OMA" id="MNGECRT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="19052" checksum="3603795D4FBBEF3B" modified="2004-10-25" version="1">MRGAGRASPSRARRYENVSKEPNTHREAGAPVHRYRLQVRNMNGECRTYELRLSSLDDGYTLEIDEWLNFPDMHLGDVTPVHVSRPVQFAVPAHEFYRRRRAFRTELIESVAAALRAGEVVRMRDSPDEYPGGHAGNPWVNWIRADLRANPGGRPPPVGDDMQDLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J17</accession>
    <name>Q63J17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AraC-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190629.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111905.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1899"/>
    <dbReference type="EnsemblBacteria" id="CAH39377">
        <property type="protein sequence ID" value="CAH39377"/>
        <property type="gene ID" value="BPSS1899"/>
    </dbReference>
    <dbReference type="GeneID" id="56598311"/>
    <dbReference type="KEGG" id="bps:BPSS1899"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5367"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HCERELA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="264"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="350" mass="39297" checksum="E96D8BCF9EBB543B" modified="2004-10-25" version="1">MTRRSTKDNLGLRRPTIPVAYLRHLLTVFEERGIDARDARAGTGLRDDVLGEPDARIAPSQWGRLVLNAIRLSGDEGIGFELGLRLRMSVHGFLGYAALTAADLRASLLVNARYFRMRNRQYRLHYAERDDGATLSLHGVQASPVLQHHAMFEIVLTGIAQNVGTVAGRADPPIELQFAWPEPDYYARYRDRLPPVRFGCAANAVWVSRDALDWPLPLADDVAHRQALAQVEREYADVRHEEGDLVARVRAELTLTAHGYPGPDALARRLLMSTRTLRRRLLDAGCGYRALVDEARLRDARRLLRASDLDLKTIAARLQFNDPANFTRAFRKWTGLTPSAYREAGGGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JK6</accession>
    <name>Q63JK6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187998.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111716.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39184">
        <property type="protein sequence ID" value="CAH39184"/>
        <property type="gene ID" value="BPSS1710"/>
    </dbReference>
    <dbReference type="GeneID" id="56598065"/>
    <dbReference type="KEGG" id="bps:BPSS1710"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5126"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TAFILME"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="19699" checksum="4B5F1D4C39C38E47" modified="2004-10-25" version="1">MSAPSRRLDRIDIGILNQLQQNARITNAELARAVNLSPTPCFNRVRALEKLGLIKQQVTLLDPQPLGLRINVFIQVSLEKQAEDALRRFEEAIDKRPEVMECYLMSGDADYLLRVVVPSMKSLERFILDQLTTIPGVSNIRSSFALKQVRYRTALPLPADGLTLADADDAPQEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JL3</accession>
    <name>Q63JL3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="13">ASA dehydrogenase</shortName>
            <shortName evidence="13">ASADH</shortName>
            <ecNumber evidence="8 13">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">asd</name>
        <name evidence="15" type="ordered locus">BPSS1704</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="8 13"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188178.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111709.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1704"/>
    <dbReference type="EnsemblBacteria" id="CAH39177">
        <property type="protein sequence ID" value="CAH39177"/>
        <property type="gene ID" value="BPSS1704"/>
    </dbReference>
    <dbReference type="GeneID" id="56598057"/>
    <dbReference type="KEGG" id="bps:BPSS1704"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6006"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MFDVPDE"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011534">
        <property type="entry name" value="Asp_ADH_gamma-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278:SF4">
        <property type="entry name" value="PTHR46278:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01745">
        <property type="entry name" value="asd_gamma"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="13 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="14">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="271"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="354"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002492"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH39177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="373" mass="39895" checksum="CC693EBDE89CB2D2" modified="2004-10-25" version="1">MNVGLVGWRGMVGSVLMQRMQEEGDFDLIEPVFFSTSNAGGKAPSFAKNETTLKDATSIDDLKKCDAIITCQGGDYTSDVFPKLRAAGWNGYWIDAASSLRMKDDAVIILDPVNLNVIKDALVNGTKNFIGGNCTVSLMLMALGGLFRENLVDWMTAMTYQAASGAGAQNMRELLAQMGALNGAVAAQLADPASAILDIDRRVLAAMNGDAMPTSQFGVPLAGSLIPWIDKDLGNGMSKEEWKGGAETNKILGKPAMGEPGSIPVDGLCVRIGAMRCHSQALTIKLKKDVPLDEINGMLASANDWVKVVPNEREASMRDLSPAKVTGTLSVPVGRLRKLAMGGEYLSAFTVGDQLLWGAAEPLRRMLRILLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW6</accession>
    <name>Q63JW6_BURPS</name>
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        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1598</name>
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    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="entry name" value="T4SS_pilus_biogen_PilP"/>
    </dbReference>
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        <property type="entry name" value="pilP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="16807" checksum="38CCEEE132147B9E" modified="2004-10-25" version="1">MMCALGVALFAGAARAAGPAPSDDGGATAARLTQLQSETVLLQAQLKKLETQQQVIERAAQLARALGGGAPAGQFAVTAIEGVGKRAFATLRMNGGAEFEVQRGDALPDGARVVAIEPRAVVVSNRGRTYRLSTGAPPSPAYAGNPPLPADAAAPLPTLPARPASGS</sequence>
</entry>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
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    <dbReference type="EnsemblBacteria" id="CAH39047">
        <property type="protein sequence ID" value="CAH39047"/>
        <property type="gene ID" value="BPSS1574"/>
    </dbReference>
    <dbReference type="GeneID" id="56530016"/>
    <dbReference type="KEGG" id="bps:BPSS1574"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4946"/>
    <dbReference type="eggNOG" id="COG4521">
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    </dbReference>
    <dbReference type="OMA" id="FIWDPVL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13560">
        <property type="entry name" value="PBP2_taurine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010068">
        <property type="entry name" value="Peri-bd_TauA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF38">
        <property type="entry name" value="PTHR30024:SF38"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01729">
        <property type="entry name" value="taurine_ABC_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267281" evidence="2">
        <location>
            <begin position="28"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="29"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="336" mass="35256" checksum="A7939B97B7A22BF4" modified="2004-10-25" version="1">MILKRILIAASFTAAAASAVHSHAARAETVNVAYQYGADPAKLAQAGAAYEKATGWKINWRRFDSGADVVAALASGDVQLGDVGQSPFTAAVSRGVPIQAVALNAITGVSEALVVRRGAHIDKPADLVGKTIATPYASNCHYALLAALKHWGIDAQRVKIVNLGPTEIVAAWARGVIDAAYTWDPALGRAKASGGKVLVDSAEVGKWGAPTFDLWAVRSDFAQAHPDFVSKFVKVTTQAIADYRANGKAWTSASRQVAEISRLSGAAAGDIAQLLAGNLYPSAAEQASPELLGGGTADAIASTARFLKEQRKIDRVLPDYRPTVTDRFVRAAIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K31</accession>
    <name>Q63K31_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Surface presentation of antigens protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bsaY</name>
        <name evidence="9" type="ordered locus">BPSS1535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205637.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111541.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1535"/>
    <dbReference type="EnsemblBacteria" id="CAH39008">
        <property type="protein sequence ID" value="CAH39008"/>
        <property type="gene ID" value="BPSS1535"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1535"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4890"/>
    <dbReference type="eggNOG" id="COG4791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPQLNAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006304">
        <property type="entry name" value="T3SS_SpaR/YscT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01401">
        <property type="entry name" value="fliR_like_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="26339" checksum="4E2655E74B72D2FB" modified="2004-10-25" version="1">MDVLMQAFYRHAGAIAIAYARVAPVFYLLPFLNDRTIVNGIVKNTIVFAIILGLWPSFAHPPLQGGALAGVALTEAAAGVVLGVALSLPFWVATALGELIDNQRGATISDSIDPATGVEASALAPFVSLFYAAAFLQQGGMLTIVGALEASYATVPAGALFSVDLPRIGALLTDLVAHGLALAAPVLIVMFVTDALLGLFSRFCPQVNAFSLSLTVKSIVAFAVFHLYFVYAAPHELTALLRVHPFSSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K55</accession>
    <name>Q63K55_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111517.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K55"/>
    <dbReference type="STRING" id="272560.BPSS1510"/>
    <dbReference type="EnsemblBacteria" id="CAH38983">
        <property type="protein sequence ID" value="CAH38983"/>
        <property type="gene ID" value="BPSS1510"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1510"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5764"/>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REVYYLC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DotU" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="23303" checksum="B90C01EF75D94D91" modified="2004-10-25" version="1">MMPLVAYARQLAQSPRGDAAEVALRLDILIERARDHAACAGAPAADVDDALFAVCAWIDEALLNSGWDDADRWTLRLLQKRYFDTSHAGVVFFERLGTLDGARASVLEVYLLCLRLGFRGRYGYDGGDGPLDAIRQRALDALSAHAPPCAAGEPPFPAAYAHAGPHAAAAKARTRRRIARAGLSVGLPLAVLLSLYLIYHVVIVRMVDAVYPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K67</accession>
    <name>Q63K67_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="8235" last="8235">
            <title>Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Lim Y.T."/>
                <person name="Jobichen C."/>
                <person name="Wong J."/>
                <person name="Limmathurotsakul D."/>
                <person name="Li S."/>
                <person name="Chen Y."/>
                <person name="Raida M."/>
                <person name="Srinivasan N."/>
                <person name="MacAry P.A."/>
                <person name="Sivaraman J."/>
                <person name="Gan Y.H."/>
            </authorList>
            <dbReference type="PubMed" id="25648885"/>
            <dbReference type="DOI" id="10.1038/srep08235"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525344.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111505.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="3WX6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B=1-169"/>
    </dbReference>
    <dbReference type="PDBsum" id="3WX6"/>
    <dbReference type="SMR" id="Q63K67"/>
    <dbReference type="STRING" id="272560.BPSS1498"/>
    <dbReference type="EnsemblBacteria" id="CAH38971">
        <property type="protein sequence ID" value="CAH38971"/>
        <property type="gene ID" value="BPSS1498"/>
    </dbReference>
    <dbReference type="GeneID" id="56530088"/>
    <dbReference type="KEGG" id="bps:BPSS1498"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4845"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WEHTTAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03344">
        <property type="entry name" value="VI_effect_Hcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3WX6"/>
        </source>
    </evidence>
    <sequence length="169" mass="18740" checksum="477D9362481BDF12" modified="2004-10-25" version="1">MLAGIYLKVKGKTQGEIKGSVVQEGHDGKIHILAFKNDYDMPARLQEGLTPAAAARGTITLTKEMDRSSPQFLQALGKREMMEEFEITIHRPKTDTTGGDLTELLFTYKFEKVLITHMDQYSPTPHKDDSNGIKEGLLGYIEEIKFTYSGYSLEHAESGIAGAANWTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K87</accession>
    <name>Q63K87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mandelate racemase/muconate lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rspA</name>
        <name evidence="2" type="ordered locus">BPSS1478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525362.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111485.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1478"/>
    <dbReference type="EnsemblBacteria" id="CAH38950">
        <property type="protein sequence ID" value="CAH38950"/>
        <property type="gene ID" value="BPSS1478"/>
    </dbReference>
    <dbReference type="GeneID" id="56530108"/>
    <dbReference type="KEGG" id="bps:BPSS1478"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4819"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYMRHTE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034589">
        <property type="entry name" value="D-mannonate_dehydratase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF6">
        <property type="entry name" value="PTHR48080:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00033">
        <property type="entry name" value="mannonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="402" mass="45062" checksum="2327BB0233A44AE3" modified="2004-10-25" version="1">MKIERLNIIVTCPGRNFVTVKIVTDEGVHGLGDATLNGRELAVRAYLEDHVFPCLIGRDPRDIEDIWQYLYRGAYWRRGPVTMTAIAAIDMALWDIKGKLAGMPVYQLLGGKSREGLMVYGHANGRDHDEAIDAAHRHIAAGYRAIRVQSGVPGLAKVYGVGKTAGAYEPAEKGLPPEEPWDTALYLRHTPELFRKVRDALGDAPHLLHDAHHRLTPIEAARLGRDLEPYRLFWLEDATPAENQDAFRLIRSHTTTPLAVGEVFNSIWDCKDLIRDQLIDYIRATIVHAGGITHVRRIADYAAMYQVRTGFHGATDLSPVCMAAAVNFGLWAPNFGIQELMPHTALTDEVFPHNYRFDDGYLVMDDVPGLGVDIDETLAANYPYERAYLPVARLRDGSMWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KD3</accession>
    <name>Q63KD3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528729.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111439.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1427"/>
    <dbReference type="EnsemblBacteria" id="CAH38902">
        <property type="protein sequence ID" value="CAH38902"/>
        <property type="gene ID" value="BPSS1427"/>
    </dbReference>
    <dbReference type="GeneID" id="56530153"/>
    <dbReference type="KEGG" id="bps:BPSS1427"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5662"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRAVGCI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="220" mass="23093" checksum="9815401928533A11" modified="2004-10-25" version="1">MERTLTAFDPHRRPFIVGIGGTTRAASSTERALGFALRGAQAAGARTRLFDGPFLHTLPHYAPERRALTDAQRELIDAVRAADALVIATPGYHGGVSGLVKNALDTLEELRADERPYLDARAVGCIVTAYGWQAAGTVLTSLRAIVHALRGWPTPFGATVNTLETRFETAGSCSDSKVAAQLETVGAQAAEFALAFASHRAATRVAGGETLAPVLEAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE2</accession>
    <name>Q63KE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane permease transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201828.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111430.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1418"/>
    <dbReference type="EnsemblBacteria" id="CAH38893">
        <property type="protein sequence ID" value="CAH38893"/>
        <property type="gene ID" value="BPSS1418"/>
    </dbReference>
    <dbReference type="GeneID" id="56530162"/>
    <dbReference type="KEGG" id="bps:BPSS1418"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4742"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIVCWFN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="440" mass="48576" checksum="0E56EA5F4D3BD0BC" modified="2004-10-25" version="1">MIPSQAAAARPLEAAGQAELDLTYRKVFWRIVPFLMLCYVVAYLDRVNVGFAKLQMSQDLAFSETVFGLGAGIFFLGYFLFELPSNMLMHRIGARIWIARIMITWGLLSALFAFVKTPTQFYVLRFLLGLAEAGFYPGVILYLTYWFPTHRRAKIIAVFMSAIPVSGIFGNPLSGWIMERFHGGSGFHGWQWMFVIEAVPAIAIGIATILYLDNNIRGAKWLTEREKKLLADEIEAQPHERDKHAHSLSTVLRDPRTWWMSLIYFTFVTGQYGLTFWMPTLVKSTGITDTLRIGLLSAIPFAFAIVAMNLFGRSADKRRERRWHLIVPALMGTVGFSVAAAYSHNTTVSILFLSIAAGGVLTCAPLFWSLPTAFLAGTGAAAGIAIINSIGNLAGFASPYLIGYLKDATSSTSAGMYVLAAMLVIGALAVWLTPAKLVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP3</accession>
    <name>Q63KP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative D-lactate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205588.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111328.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1318"/>
    <dbReference type="EnsemblBacteria" id="CAH38789">
        <property type="protein sequence ID" value="CAH38789"/>
        <property type="gene ID" value="BPSS1318"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1318"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4613"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RACNAYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="70"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="497" mass="52549" checksum="8123A57694AC1079" modified="2004-10-25" version="1">MREVTDDGQQWDGRAAAFAGVPSGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVREQHGKDISFHPGAPPDAVAFVRTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGVCIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGLFFPIDPGADASIGGMCSTRASGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGVTLRLHPRPDRLSAAVCSFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSLDERPTLFFEFAGFGAAVDEQIDWVGEICAGYGGGEFRWASRPEERSALWAARHDAWWAALALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATICGHVGDGNFHVCIAIDPADADELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRGIMNPGKVLHHDRYPPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS6</accession>
    <name>Q63KS6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS1286a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184472.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111295.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38756">
        <property type="protein sequence ID" value="CAH38756"/>
        <property type="gene ID" value="BPSS1286a"/>
    </dbReference>
    <dbReference type="GeneID" id="62345154"/>
    <dbReference type="GeneID" id="66550046"/>
    <dbReference type="KEGG" id="bps:BPSS1286a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4566"/>
    <dbReference type="eggNOG" id="ENOG50329RB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MFNNTGK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="57" mass="5844" checksum="21A0A9C511EA7D42" modified="2004-10-25" version="1">MKVMTMEQAKVVNGGGPISSLGTLAAASGPLFTALGQFMPTLGGYLQNPKNFNSNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS8</accession>
    <name>Q63KS8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Family C39 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSS1285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111293.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1285"/>
    <dbReference type="MEROPS" id="C39.005"/>
    <dbReference type="EnsemblBacteria" id="CAH38754">
        <property type="protein sequence ID" value="CAH38754"/>
        <property type="gene ID" value="BPSS1285"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1285"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5485"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPLNWAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="13">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="172"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="488"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="522"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH38754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="714" mass="78875" checksum="043683F786D2B86B" modified="2004-10-25" version="1">MSSDSQAMWFNTNKVRPILQDEVTECGLACLAMIATWHGRDTTLRTLRNRYPVKIDSGLSFFDLMEIANDLGMRARGLQFEANEIDALKLPCILHWGMNHYVVLTKVCYGSVHIVDPALGETKLPLAQALTQITGYALELNPDIGFKHVGTSDKIRLGDYLVGLTGIRKSILLGVAGGIAAQLLLLLGPSYVQLTIDEALKKTDVDILYLLTILFGIVFLFDTLYANLVGNIKSYLRNIVSQQLSANMVGHLARLPIGYYLFHNTGDSISRVSSVSEIGRFLVDGLIGGLLNVFTCVITLVLMLYYSPVLAGISLAGMVLFALSRLAIQPQLQDAMSQILTRGAEADALLIENIRSAHSIKLLSSETSRSSLWVNAFTQKLQAVRQQERLQLLFDAISKGIVHVEQLVIVTYGAWLVMHGQSTIGIIYAFIQYKNLFADKFVDSIQLYVRRKVLQVHMDRVADVLQTETEEPAPDAPVRSIEHFDGSLSIRALTYTPKGGRRAILEDVNLDVPAGAKIAIVGRTGSGKTTLLNLICGLYPPAPGALFVGGVDLSEVNLRLYRKHVAAVTQSDQLFRGTIRDNITNFAPAPRLGAMHEAARLACIERDIDVLDNRYDTPLGDTQKFLSAGQMQRLLIARALYCEPRLLILDEFSSNLDQATTHEICRNVLTLPCTIVLVTHDASILSMVDRIYEMRDGRLADITPARQPELEVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KT6</accession>
    <name>Q63KT6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184355.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111285.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1278"/>
    <dbReference type="EnsemblBacteria" id="CAH38746">
        <property type="protein sequence ID" value="CAH38746"/>
        <property type="gene ID" value="BPSS1278"/>
    </dbReference>
    <dbReference type="GeneID" id="56530304"/>
    <dbReference type="KEGG" id="bps:BPSS1278"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4554"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRLRHWD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="432" mass="46100" checksum="DCF41E100989DD11" modified="2004-10-25" version="1">MHVLVVGAGIAGLAAAWQLKRGGCDVTVVEAAERAGGRIRSAPFHGHVIECGAQFPSSGYRHLMPLFGEAGLDAQLVKTSPWAAFEHRGRLFRVHARRPWTIPASGLLGWRDSVRVSRARAALLARVRALDPNRYAAFAEFDDADAAHWAERAFGRAAVDAIFAPMIHGLYFQPLRGASRALLAAVTGFDGADTLAVAGGWQTLPVALAARLDVRYGTRVDALSAHANGVDACVGDRALRFDAAIVATPATVARRLWRGQTDAQRALLATGYARCAHVAFGLAPGWRAPARLRRVYGALLSPHARRVAALTFERGRGIGDGQGEVVSAMLGHAGASALRYASDDEIARVALDDLRTLLPGVAEAVVATRVQRWDEAEPLSPVGRARAIAAYRASIDARPRVLLAGDYMGSPWTDGAAETGRWAARRLLDARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L91</accession>
    <name>Q63L91_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940263.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111130.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1117"/>
    <dbReference type="EnsemblBacteria" id="CAH38585">
        <property type="protein sequence ID" value="CAH38585"/>
        <property type="gene ID" value="BPSS1117"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1117"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4333"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LCQGHCP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="223" mass="24714" checksum="8AE1BB7FC59A5DAF" modified="2004-10-25" version="1">MDDNFSKQEIPVSERVLNVLKRRGPLQAAELGAYLGTTGEAARQQLKKLEAEGLVEAQNVPQGVGRPARIWRLTSLGHGHFPDAHADMTVDLIRIIRTTLGQPTLDLLIAARETEMRRTYAHTLAGVTDPEERIARLAELRDREGYFAEWSRAPDGDGWLFIENHCPICAAATACQGFCRSELEIFREMLGDALTIERIEHIPAGARRCAYRIRPSGADAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LC9</accession>
    <name>Q63LC9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage baseplate assembly protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205529.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111092.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1080"/>
    <dbReference type="EnsemblBacteria" id="CAH38547">
        <property type="protein sequence ID" value="CAH38547"/>
        <property type="gene ID" value="BPSS1080"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1080"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4278"/>
    <dbReference type="eggNOG" id="COG3948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QTHERKY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014507">
        <property type="entry name" value="Baseplate_assembly_J_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020481">
        <property type="entry name" value="BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="104"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="301" mass="32526" checksum="028D0323EA8C1858" modified="2004-10-25" version="1">MRSTPIDLSQLPAPDIVDPLDFETLFAERKARLVSLYPPEHQAEIAATLALESEPVTRVLQENAYREVLLRQLINDKARGLLLAYARGTTLEHIAALFDVERLVVTAADPEHGIDAVYEDDDSLRERVQLAPRGFSVAGPEEAYVFHARAADGRVLSASARSPEPCVMVVTVLSREGDGTASDALIDIVRAALEGVRPQTDQVIVQSAQVVPYAIRATLRFFSGPDRGVALAEARKRTAKFAADMRRIGMEITVDGLHAAMRVAGVQKVLLDSPAGGVPVTHEQAPYCTGIELIDGGVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M20</accession>
    <name>Q63M20_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200942.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110851.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0840"/>
    <dbReference type="EnsemblBacteria" id="CAH38302">
        <property type="protein sequence ID" value="CAH38302"/>
        <property type="gene ID" value="BPSS0840"/>
    </dbReference>
    <dbReference type="GeneID" id="56597166"/>
    <dbReference type="KEGG" id="bps:BPSS0840"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7117"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGWFGAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="177"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="346" mass="36565" checksum="BEE9B8FD4654E3A6" modified="2004-10-25" version="1">MKALVYHGPGRKSLDERPMPELAAPTDVIVRVTRTTICGTDLHILKGDVPSCEPGRVLGHEGVGVVHRAGGAVSTFKEGDRVLISCISSCGQCEYCRRGMYSHCATGGWILGNRIDGTQAEYVRIPHAQTSLYRIAPGADEEALVMLSDILPTGFECGVLNGRVQPGGTVAIIGAGPIGLAALLTAQFYSPAQIVMIDPDPNRLALARRFGATACIDNGQVDAVAGVKALTGDGVDCAIEAVGIPASFELCQRIIAPGGVIANVGVHGMKADLHLETLWDRNITITTRLVDTSSTPMLLKTVGAGRLDPKQLITHRFSLADIGQAYETFGHAAHTRALKVIVEVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MD6</accession>
    <name>Q63MD6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195584.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110735.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63MD6"/>
    <dbReference type="STRING" id="272560.BPSS0721"/>
    <dbReference type="EnsemblBacteria" id="CAH38181">
        <property type="protein sequence ID" value="CAH38181"/>
        <property type="gene ID" value="BPSS0721"/>
    </dbReference>
    <dbReference type="GeneID" id="56597602"/>
    <dbReference type="KEGG" id="bps:BPSS0721"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6947"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VGEATAW"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="253" mass="27824" checksum="A9E1E8519CD0EE74" modified="2004-10-25" version="1">MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVVPCDVREPGRLEDVFARIAQEWGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCHSFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPVKAALEGSVRYLAAELGPRRIRVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTGNVEYIDGGYHVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MD9</accession>
    <name>Q63MD9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110732.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0718"/>
    <dbReference type="EnsemblBacteria" id="CAH38178">
        <property type="protein sequence ID" value="CAH38178"/>
        <property type="gene ID" value="BPSS0718"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0718"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4772"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAQTIYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="214" mass="23241" checksum="446F0C6D1C2CE519" modified="2004-10-25" version="1">MLDDWSNPALSSTLMNAATTADVRQHILDTAKPIMLCKGFTGVGLNEILAAAGVPKGSFYHYFGSKEAFGESILESYFDDYVAHLDELLVRGPGAAIDRLMRYWTQWQQMQMGNDPEGKCLVVKLGAEVCDLSEAMRAALERGTSQIVARLAACIAAALDDGSLKVDLEPQQTAAMLYELWVGATLIEKIRRDGEPLAVAMASTRRVLGLTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MF2</accession>
    <name>Q63MF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205450.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110719.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0705"/>
    <dbReference type="EnsemblBacteria" id="CAH38165">
        <property type="protein sequence ID" value="CAH38165"/>
        <property type="gene ID" value="BPSS0705"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0705"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6920"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RSFIVIN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="223" mass="24646" checksum="B3BBDE38E0BE4423" modified="2004-10-25" version="1">MRVLLVEDNPILAQSLADALSSARFAVDHMADGEAADHVLHTQDYALVILDLGLPKLDGLDVLRRLRARRNPVPVLILTAHGSVEDRVRGLDLGADDYLAKPFELTELEARARALIRRSLGHEHGRVECGPLAFDSVDRIFRLNNDALALTPRERSVLEVLILRNGRAINKETLSEKIFGLDESVNADAIEIYVHRLRKKLEGSGVAIVTLRGLGYLLEAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ML8</accession>
    <name>Q63ML8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0632"/>
    <dbReference type="EnsemblBacteria" id="CAH38089">
        <property type="protein sequence ID" value="CAH38089"/>
        <property type="gene ID" value="BPSS0632"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0632"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSEFYQP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="57"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="771" mass="82597" checksum="45A802ABBD5D3E1B" modified="2004-10-25" version="1">MPDAGAGAPSAPTPPTAATPAAAGASASTAAAPTPAATDTLVCMPDGGGPHRPAIGLVLSGGGARGYAHLGVLKVLEANRIPVDCIAATSMGAVVGGLYATGMTAQDMQRRLSQVNLADIAFDVTERSDLPQKKREDERLYIDSLTIGFDSKGFKAPVGLVQGNRLQALLANWTAAVPTSQPFDRLPIPFRAIATDLQTGQKVVLDHGSLPLAIRASMALPGLFSPAEIDGRALVDGGLVGNLPVDAARAMGADVVIAVDIGSPLRPLDALASPADVMQQMIGILIRQNVAEQRKQLTANDILLQPDLGKQTFTDFQNANQAIAAGEAAAVAALPRLARYALSPEQYEAYRAAHARPQQPIRITSIEIRTNGASVPKQIVRNALHVKPGDVYDPQAVSADLLSLTTSGNFENVTQQIINEGDEHRLVIDAQEKYWGPNFLLFGLGMSSSSTDEGGFRLHLGYRRPWLTPSGLEFRADTTLGSDMQSVHVELRQPLSNKTGYYVAPYADYKRRFANLYNGESDVKVTQYRIQTSRAGLDLGLPLARLGDFRIGLAYTHLSAAPSYSLLLDSWVDDDGNSLSFPSWYARQVSARARLVIDQLDDPLFPRKGYFAEFRAERSLATSEDKFTDVYGKLMVAERFGRHSVSASVEAGKSFGGVNLSNPFGYTLGGFQHLSAYAADQLSGDALLYGQVTYMNQLATFNASPIKALYLGASAEVGNVWSLDPAFPSGPLKQSYTFFTSLITSFGPVYVGMAFAPGGRRNIYFQLGRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MM1</accession>
    <name>Q63MM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545901.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110650.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0629"/>
    <dbReference type="EnsemblBacteria" id="CAH38086">
        <property type="protein sequence ID" value="CAH38086"/>
        <property type="gene ID" value="BPSS0629"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0629"/>
    <dbReference type="OMA" id="SGPCAMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="102" mass="10920" checksum="64AB3D64B73629A9" modified="2004-10-25" version="1">MEPSRRRFVKHRLAAATVAVVVAVAAAKETKETKETDKVGKVGKAAIVQTAAVRSGPCAMRAAMRARRRARVRRRRAGHFEAAPHGPPTGDFGGRGCDRCVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MM6</accession>
    <name>MACB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">macB</name>
        <name type="ordered locus">BPSS0624</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523215.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110645.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63MM6"/>
    <dbReference type="SMR" id="Q63MM6"/>
    <dbReference type="STRING" id="272560.BPSS0624"/>
    <dbReference type="EnsemblBacteria" id="CAH38081">
        <property type="protein sequence ID" value="CAH38081"/>
        <property type="gene ID" value="BPSS0624"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0624"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6808"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVILITH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51267">
        <property type="entry name" value="MACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000269929" description="Macrolide export ATP-binding/permease protein MacB">
        <location>
            <begin position="1"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01720"/>
        </source>
    </evidence>
    <sequence length="653" mass="70312" checksum="EC9A3DEC22D9210A" modified="2004-10-25" version="1">MTGPLLQLTRVTRRFPAGEKDVVVLDDVSLSIDAGEIVAIVGASGSGKSTLMNILGCLDHPSSGSYTVGGRETSELESDELARLRREHFGFIFQRYHLLPHLCAAENVEMPAVYAGSAQAQRRERALALLARLGLSDRASHRPSQLSGGQQQRVSIARALMNGGEVILADEPTGALDSKSGRDVIRVLRELNALGHTVIIVTHDEQVAAHARRIIEISDGRIVGDRLNPHADAADAAPDASGGAQPQRARRLSAGVGRFAEAFRMAWIALVSHRLRTLLTMLGIIIGITSVVSIVAIGEGAKRYMLDEIGSIGTNTINVYPGADWGDSRADAIQTLVAADAAALADQIYIDSATPETSRSLLLRYRNVDVNALVSGVGERFFQVRGMKLAQGIAFGADEVRRQAQVAVIDENTRRKLFGANPNPLGEVILIDNLPCVVIGVTASKKSAFGDMKNLNVWVPYTTASGRLFGQRHLDSITVRVRDGQPSDAAERSLTKLMLQRHGRKDFFTYNMDSVVKTVEKTGQSLTLLLSLIAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARQTDIMQQFLVEAVTVCLMGGAIGIVLSFGMSFVFSLFVDQWKMVFSAASIASAFLCSTLIGVVFGFMPARNASRLDPIDALARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MM9</accession>
    <name>Q63MM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523212.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110642.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0621"/>
    <dbReference type="EnsemblBacteria" id="CAH38078">
        <property type="protein sequence ID" value="CAH38078"/>
        <property type="gene ID" value="BPSS0621"/>
    </dbReference>
    <dbReference type="GeneID" id="56530928"/>
    <dbReference type="KEGG" id="bps:BPSS0621"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6804"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRSVAFS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="27890" checksum="2EDE6DD1892BE8C3" modified="2004-10-25" version="1">MIELDYADDGAIALVTLKRPSANTFSADGLLELQRTIERLEADSRVRALVVTGDGPKFFSAGADLNSFADGDHAMARTMASRFGAAFEALHDARFPTIAAINGYAMGGGLECALACDMRIAERHAQMALPEPSVGLTPCGLGTQTLPWLVGEGWAKRMILAGVRVDAQTALRIGLVEEVVDAGRARDAAIELARGAAALGPRALGVAKALIGLARQGVPRGAALALERERFVDLFDGGEPREGVAAFLGKRKPQWRSDEGGQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS8</accession>
    <name>Q63MS8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535045.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110591.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0570"/>
    <dbReference type="ESTHER" id="burma-q62dg2">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.951"/>
    <dbReference type="EnsemblBacteria" id="CAH38027">
        <property type="protein sequence ID" value="CAH38027"/>
        <property type="gene ID" value="BPSS0570"/>
    </dbReference>
    <dbReference type="GeneID" id="56530980"/>
    <dbReference type="KEGG" id="bps:BPSS0570"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6739"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLRDDAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="80"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="33773" checksum="29F6E826C0EDAC41" modified="2004-10-25" version="1">MLEPTIEAFVARVAAWYPDDAAARPIAEQRALYERFAAAWTPALPADVDTRDARLGAFGDGREIRLRRYRSRCAAACGTVLFFHGGGFVVGSLDSHALMTARIAADTGLDVIAVDYRLAPEHRAPAAFDDCLAVTLAALDGRLPFESIALPLRLAGDSAGGMLAASVATALRDGGRIGRDGGGRAGGGVCAVALVYPMLGFEPQAPARDTHAHAPMLTLDDVHAYRRHYWGDAGAPPGALPLDARRFDGLPPVLAIGAAHDPLRDDARVYAERIRSAGGAARFWCGDGLVHGCWRALDTSAQAARMHRAVCEFLLAPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N83</accession>
    <name>Q63N83_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525432.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110436.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37868">
        <property type="protein sequence ID" value="CAH37868"/>
        <property type="gene ID" value="BPSS0413"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0413"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6546"/>
    <dbReference type="eggNOG" id="ENOG50330RY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QDIETDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="15097" checksum="75CC8B73F65BEF07" modified="2004-10-25" version="1">MYPWIWLWAPNFYFPLSGGVDQTIQPDLFDAINSRAGNGEIERKAFQVASYGRQLGLIIEVLLDMAKKQEALSPEAKQSMERLEAIQGEIEQIKREAPTSIAADLAARLLQLKTQNPAEFVRLRAQLLGIVKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NP5</accession>
    <name>Q63NP5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ribose ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533774.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110274.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0255"/>
    <dbReference type="EnsemblBacteria" id="CAH37701">
        <property type="protein sequence ID" value="CAH37701"/>
        <property type="gene ID" value="BPSS0255"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0255"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4221"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HKQFTEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="265"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="505" mass="54256" checksum="7A0009343BE970AF" modified="2004-10-25" version="1">MSKSSVTLRDTTVTPVLLEASQVAKRFNGVSALRDGRLSLAAGRVHALCGGNGTGKSTFLNILMGLLRRDEGTIRLNGRDVDFASPAEALASRMAIITQELSPVPGMTVAENLYLGREPTRAGVVVDFRALKRRAQALLDRLGFAIDAGAPMHRLSLAQTQLVEIAKAFSHDCQVMIMDEPTSAIGERETETLFAAVRNVTAHGAGIIYVSHRLSELFDIADDYTVFRDGAYVESGRLADIDRAHLVRAIVGREMPVVDKARRPAHGEPCLKVEGLTRANEFEDVSLDVRRGEILGIYGLMGSGRSEFLNCVYGLTRPDAGAATLGGKPLPHGEPARSIRAGIALVTEDRKDSGLVLCGSVQENIAMAAYRRLSRGGVIRRSLVRRLAQAMVERLRIKAASLRMPVSAMSGGNQQKVVLAKCLSTAPVLLLCDEPTRGIDEGAKQEIYRLLDAFARDGGAVIVVSSEAPELLYLSDRIAVFKGGRVAAVRPGDGATQESLLHLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P60</accession>
    <name>Q63P60_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS0086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939072.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110109.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0086"/>
    <dbReference type="EnsemblBacteria" id="CAH37532">
        <property type="protein sequence ID" value="CAH37532"/>
        <property type="gene ID" value="BPSS0086"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0086"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6107"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPWGSEG"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01663">
        <property type="entry name" value="Cyt_c_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033944">
        <property type="entry name" value="Cyt_c_oxase_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="531" mass="59245" checksum="C8D32EA79F07C137" modified="2004-10-25" version="1">MSEISTNMPHVRDAAHHAPTGWRRWLFATNHKDIGTLYLLFSIVNLMIGGVMALMIRAELFEPGLQLMRPEFFNQLSTEHGFIMIFGAIMPAFVGLANWMIPLQIGASDMAFARMNNFSFWLLPVSSALLIGSFFVPGGAPAAGWTMYAPLSTQMGPGMDLSIFAIHIASASSIMGAINIVVTVVNMRAPGLTLMKMPMFAWTWIITSFLLIAIMPVLAGAVTMVLFDRHFGTSFFNASGGGDPVLYQHIFWYFGHPEVYVMILPGFGMISQVIPAFSRKPLFGYASMVYATASIGILSFMVWAHHMFVTGMPVAGQLFFMYATMTIAVPTGVKVFNWVATMWRGSLTFETPMLFSIGFIFVFLIGGLTGVTLAMAPLNVALHGTYYIIAHFHYVMVAASLFSIYAGWYFWVPKWTGYFYDERRGRIHFWGSMISFNVTFFPMHFLGLAGMPRRYAGYPAQFTDFNQIATIGAFAFGLMQVYFLFWVALPTYLGKTRRCVDAKPWDGAQGLEWTLPSPAPYHSFETPPAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P73</accession>
    <name>Q63P73_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110096.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37518">
        <property type="protein sequence ID" value="CAH37518"/>
        <property type="gene ID" value="BPSS0074"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0074"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="120" mass="13403" checksum="BA155FBB91C0EBA9" modified="2004-10-25" version="1">MLIEAVGTRAWVCHQCDPIDSIVSQPFHGALKQLTSNTHTVKDRFNKQSRNERSIGNDRETYSGHLVVAFADPSAALANLFDQKAAVEQMNLVWVDSILGYREADVVKCTDVTLSHRTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PB3</accession>
    <name>Q63PB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194548.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110056.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63PB3"/>
    <dbReference type="STRING" id="272560.BPSS0032"/>
    <dbReference type="EnsemblBacteria" id="CAH37475">
        <property type="protein sequence ID" value="CAH37475"/>
        <property type="gene ID" value="BPSS0032"/>
    </dbReference>
    <dbReference type="GeneID" id="56596777"/>
    <dbReference type="KEGG" id="bps:BPSS0032"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6031"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIVVHAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="16571" checksum="E97B48D68CAABED4" modified="2004-10-25" version="1">MYQRILVAVDGSETARHAFDAALDIARTSGAELQPFYVVENAAIYYNVPGYDPSILRTQLLQQGNELAKEFAEKMQAAGVKGALKIGEATSLADVPSLIVEGAKAFGADLLVLGTHGRRGFKRLVLGSVAEQCVRHSALPVLLIPAAAHPEDRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PC1</accession>
    <name>Q63PC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201048.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110048.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0024"/>
    <dbReference type="EnsemblBacteria" id="CAH37467">
        <property type="protein sequence ID" value="CAH37467"/>
        <property type="gene ID" value="BPSS0024"/>
    </dbReference>
    <dbReference type="GeneID" id="56596769"/>
    <dbReference type="GeneID" id="66548810"/>
    <dbReference type="KEGG" id="bps:BPSS0024"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6023"/>
    <dbReference type="OMA" id="GTIMATK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="66" mass="7158" checksum="D4C4FD09E7F1E038" modified="2004-10-25" version="1">MATKPKKTKGVSVSIEGKLPKMTLDMPVDAKKIKAIQKCLENGKLTITMSKVDLAGGRMGEGYLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PE4</accession>
    <name>Q63PE4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KfrA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194527.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110025.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0001"/>
    <dbReference type="EnsemblBacteria" id="CAH37444">
        <property type="protein sequence ID" value="CAH37444"/>
        <property type="gene ID" value="BPSS0001"/>
    </dbReference>
    <dbReference type="GeneID" id="56596744"/>
    <dbReference type="KEGG" id="bps:BPSS0001"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5995"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QSTEHYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021104">
        <property type="entry name" value="KfrA_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11740">
        <property type="entry name" value="KfrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KfrA_N" evidence="2">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="395" mass="43724" checksum="AA1799C36B6B4B91" modified="2004-10-25" version="1">MTLDEIRQSIREELDALRVSGARRQDLSLHACKRLFFDLGIRPSTANVRELTQTGSASDIPKDIDHFWERIRSASKVRLEGAALPKPLEEKAGALLGALYEEALKQARESLDGERQQASSEVAAAEQKYRDALIRQEALEAAVARSDARAEQLQSRLTDVEVQLASASTQGLAHQDSLQGLIRRMENENALLNQRLEAEQSQNAALRERIDALHAELRENTEHYAQQIKDAIAEAERRVKPMLVELDSLRSMASTYQQGLRDVNRKEFDFLQQLSAAKARADRLDAQLREQGDELTAALNEVQILRASQGMTPEIAALIRRLANAGNLDAAAFDTIGTSLDQHVTLPARCPKCGDGEPELSHDAHGYELLCPECEHASGTQPSRFAAAACFTRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PP0</accession>
    <name>Q63PP0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acpA</name>
        <name evidence="4" type="ordered locus">BPSL3333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109929.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3333"/>
    <dbReference type="EnsemblBacteria" id="CAH37346">
        <property type="protein sequence ID" value="CAH37346"/>
        <property type="gene ID" value="BPSL3333"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3333"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3788"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YFANYAP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017768">
        <property type="entry name" value="AcpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03397">
        <property type="entry name" value="acid_phos_Burk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="577" mass="62804" checksum="4AF0C7665C40FA39" modified="2004-10-25" version="1">MRASPVRAPTRGGPSNQPEDRGAEVTDKHPPSTDLPEDPDRRRVLGGIAALGASVALAGCETAVPAAPRSAAELRLDAVLRREVRNIVVIYAENRSFANLFGDFPGVQQPLGAVSPERYAQLDRDGKTPLATLPKIWGGLVPQAQVVDGKRYMIGEHDIVGLPNAPFVIPDAQGKPLPNGVITRDLWHRFYQNQMQINGGRNDQFAAWADSGGLVMGHYRNSAETLRLWNLARGYTLCDNFFMAAFGGSWLNHIFLISAQAPLYPDVHQSPAKHLVSVVEGDDPAGTRLKLAADSPASALDGPPKFENDGLFTPDGYAVNTMAPPYQPSSVRPPVEGNPAYADPSNPRVLPPQHYATIGDRLSEKGVDWAWYGGAWQYALEHRDTGSVPDFQYHHQPFNYFASYAPGTEARRRHLRDAGLGDDPSTNHLIADIDAGRLPTVTFYKPQGNLNMHAGYADVASGDRHIATVIEHIMRGPQWAHTVVILTVDENGGWWDPVSPPKGDRWGPGSRIPAMVISPFAKKGYVDHTLYDTNSILRFISRVHGLAPLDGVLARERAFAARGAQPPGDLTEALDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PS4</accession>
    <name>Q63PS4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Protein phosphatase CheZ</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Chemotaxis protein CheZ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cheZ</name>
        <name evidence="9" type="ordered locus">BPSL3299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CheZ family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524402.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109895.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3299"/>
    <dbReference type="EnsemblBacteria" id="CAH37312">
        <property type="protein sequence ID" value="CAH37312"/>
        <property type="gene ID" value="BPSL3299"/>
    </dbReference>
    <dbReference type="GeneID" id="56593996"/>
    <dbReference type="KEGG" id="bps:BPSL3299"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1918"/>
    <dbReference type="eggNOG" id="COG3143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGPQIHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007439">
        <property type="entry name" value="Chemotax_Pase_CheZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04344">
        <property type="entry name" value="CheZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002884">
        <property type="entry name" value="CheZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Enhances dephosphorylation of CheY-P" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002884-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="26471" checksum="57962E1C022E3970" modified="2004-10-25" version="1">MNEPIDVAVAGANAGERLADAADLASDRILARIGQLTRTLRDSMRELGLDKHVEKAAEVVPDARDRLRYVVAMTEQAAERVLTAIEVAKPVQERLQQEAAALDARWAKWYETPIERAEVRGLMDDTRAFLRALPDATGATNAQLLEIMLAQDFQDLTGQVIKKIMDMVYLIEQQLLNVLVENIAPERREQFAATAAALAAEQAGGAMTPESLLNGPQINPEGKTDVVQDQAQVDDLLASLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q44</accession>
    <name>Q63Q44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109774.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3180"/>
    <dbReference type="EnsemblBacteria" id="CAH37191">
        <property type="protein sequence ID" value="CAH37191"/>
        <property type="gene ID" value="BPSL3180"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3180"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3633"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLYVRER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="699" mass="76304" checksum="4BD0088B09F94C69" modified="2004-10-25" version="1">MRFAIALLVVLSIASIIGTVLTQDDPYPNYVNQFGPFWADIFRSLSLYTVYSAWWFMLILIFLVVSISLCVIRNAPKMLADAKSWKDKVREGSLRAFHHKAEFAVAGDRARATQTVAAFVAKAGYRHVVREAGGATLVAAKRGAMTKFGYIAAHLAIVVICVGGLLDSNLPIKFQMWMFGKSPVNTSATISEIGAEHRLSASNPTFRGYAWVPEGQYVSTAILNQPTGSLIQDLPFSIQLEKFIVDYYSTGMPKLFASDIVVVDRETGKRIPARVEVNKPFAYKGVSIYQSSFQDGGSLMEMTAYPMTGASAATFPFKGTIGNSVPLAAAGADGETVEFSDFRAINVENVTDANGKTDARGVAANRSIKELFDARLGSGAKTSKPVELHNIGPSVQYKVRGKDGQAREFNNYMLPVDMGGERVFLAGVRASPNDPFRYLRIPADSRDSVGEWMRLRAALEDPAVRIEAARRFARHSLGTGDAALRDRLEDSAQRVLTLFAGADGSIGRGADGNPIGGFQSVATFIDRSVPKDEKEKAAALLLRMLEGSMWEVWQIARERAGEPPVQQAQDTVRFVQNAINALSDSFLYGAPVYLQLDSFKQVQASVFQLTRAPGKNLVYLGSLLLVAGIFAMFYVRERRLWFWLKDTGAGVSVLMAMSTARKTFDFEKEFVQTRDAAGAALGAPAFRAPDGAGTKDSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q45</accession>
    <name>Q63Q45_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554622.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109773.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3179"/>
    <dbReference type="EnsemblBacteria" id="CAH37190">
        <property type="protein sequence ID" value="CAH37190"/>
        <property type="gene ID" value="BPSL3179"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3179"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2059"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MWYSVAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="187"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="43992" checksum="8FDEE74342663338" modified="2004-10-25" version="1">MDLTQVSSSRARRASGAAAPLLFDERPFLRRLSLVDWLFALALVAGAGFALARYHAHMDYYDTAVLIGTVPALVALGWRWKPARLLMAAIAALSLVSLQLYHGDLARADSAFLLKYFLSSQSAILWMSALFVLATLFYWIGMLSRSETGGAIGQRLTWIAVLMGFTGLMVRWYESYLIGADVGHIPVSNLYEVFVLFSLITALLYLYYEGHYGTRALGAFVLLVISAAVGFLMWYSIARDAQQIQPLVPALQSWWMKIHVPANFIGYGSFALSAMVAVAYLSKERGVLADRLPTLEVLDDVMYKSIAVGFAFFTIATILGALWAAEAWGGYWSWDPKETWALIVWLNYAAWLHMRLMKGLRGTVAAWWALTGLLVTTFAFLGVNMFLSGLHSYGKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QT9</accession>
    <name>PROA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="1">GPR</shortName>
            <ecNumber evidence="1">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proA</name>
        <name type="ordered locus">BPSL2935</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH36945" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36945.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109529.2">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QT9"/>
    <dbReference type="SMR" id="Q63QT9"/>
    <dbReference type="STRING" id="272560.BPSL2935"/>
    <dbReference type="EnsemblBacteria" id="CAH36945">
        <property type="protein sequence ID" value="CAH36945"/>
        <property type="gene ID" value="BPSL2935"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2935"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2345"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000189709" description="Gamma-glutamyl phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="423" mass="45106" checksum="6C80A878C798A1FA" modified="2005-08-30" version="2">MDIDQYMTDVGRRARRASREIARASTAAKNAALEAVARAIGRDADALKAANARDVARAKDKGHDAAFVDRLTLSDKALKTMIEGLRQVATLADPIGEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALAKLIGEGLAAAGLSQDAVQVVGTADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASVAKALAVCDNAKTHRYGTCNTMETLLVARGIAPAVLTPLGRLYREKGVELRVDADARAVLEAAGVGPLVDATDEDWRTEYLAPVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU0</accession>
    <name>Q63QU0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15 16">Protoporphyrinogen IX oxidase</fullName>
            <shortName evidence="15">PPO</shortName>
            <ecNumber evidence="15 16">1.3.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">BPSL2934</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:62000"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 16">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cell membrane</location>
            <topology evidence="3 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15 16">Belongs to the HemJ family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="15 16"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531998.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109528.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2934"/>
    <dbReference type="EnsemblBacteria" id="CAH36944">
        <property type="protein sequence ID" value="CAH36944"/>
        <property type="gene ID" value="BPSL2934"/>
    </dbReference>
    <dbReference type="GeneID" id="56528263"/>
    <dbReference type="KEGG" id="bps:BPSL2934"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3354"/>
    <dbReference type="eggNOG" id="COG1981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRLFIYH"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070818">
        <property type="term" value="F:protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02239">
        <property type="entry name" value="HemJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005265">
        <property type="entry name" value="HemJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40255">
        <property type="entry name" value="PTHR40255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03653">
        <property type="entry name" value="UPF0093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004638">
        <property type="entry name" value="UCP004638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="13 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAH36944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="140" mass="15936" checksum="9A5B3E7FDCF36129" modified="2004-10-25" version="1">MAMLWVKTFHIVLIASWFAGLFYLPRIYVNLAMETDPAARRRLLAMARKLLRFMTIIAVPALACGLWLWLVIGIGQGQGWVHAKLGVVLLLVVYHAYCGHLLKVFERGENRRSDKWYRVFNELPVLGMLAAVALAVIKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU1</accession>
    <name>Q63QU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527743.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109527.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2933"/>
    <dbReference type="EnsemblBacteria" id="CAH36943">
        <property type="protein sequence ID" value="CAH36943"/>
        <property type="gene ID" value="BPSL2933"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2933"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2347"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QEDTEIY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="119"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35066" checksum="09CFAAC4B1CDA40E" modified="2004-10-25" version="1">MLPRIETIRAQLRPSERKLADFVLAAPREVLDLSMTELAARAGASQPTIARFCQALGCSGFREFKIRLAQSVAPGVASVYRDVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVAEAIELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSDPHTFSMSAALLGANDVVVAISNTGRTRDIVDAARAALACGAKVISITHSHSPLAQLSTVSLASNVAEETDVFSPMTSRMSHLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGADAKAQKETGKDATKVAASGVAGDAAESAQQAARAQAPQVGEKTRIARDIEDVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU3</accession>
    <name>Q63QU3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">eda</name>
        <name evidence="5" type="ordered locus">BPSL2931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109525.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2931"/>
    <dbReference type="EnsemblBacteria" id="CAH36941">
        <property type="protein sequence ID" value="CAH36941"/>
        <property type="gene ID" value="BPSL2931"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2931"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3349"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFPAEYC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="21702" checksum="F2E231710E8F83A7" modified="2004-10-25" version="1">MMKTIGEIVKLGPVIPVLAFDSVEQGEQVSRALHAGGVKVLEITLRTAAGLEAIRRASELAEDIVVGVGTITKPEQCALAKQAGAKFGVSPGLTRQMHAAAVDAGLPLLPGVMTPTDIIVALELGYEIVKFFPAQQAGGVPMLQAFHGPFPTLRFCPTGGITAETAPSFLKLPNVVCVGGSWLTPKAALAAQDWAEITRLAQAASGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R34</accession>
    <name>Q63R34_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">hmpA</name>
        <name evidence="24" type="ordered locus">BPSL2840</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541395.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109434.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63R34"/>
    <dbReference type="STRING" id="272560.BPSL2840"/>
    <dbReference type="EnsemblBacteria" id="CAH36850">
        <property type="protein sequence ID" value="CAH36850"/>
        <property type="gene ID" value="BPSL2840"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2840"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2461"/>
    <dbReference type="eggNOG" id="COG1017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0216">Detoxification</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 21" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="21" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="22">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="149"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAH36850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="402" mass="43555" checksum="3F264B179AF4DAA0" modified="2004-10-25" version="1">MTQMTAEQMARVKATAPVLAEHGATITKHFYQRMFGRHPELKNVFNQTHQKTGSQPETLAKAVYAYAANIDNLGALGGAVSRIAHKHASLNIRPEHYPIVGENLLASIVEVLGDAVDADTLEAWRIAYGQLAAILIGAEANLYENAAWSGFRPFKVAKKVRESDEITSFYLTPADGGAAPGFEPGQYISVKRFVGDMGVDQPRQYSLSDAPHGKWLRISVKREAGHSEAVPAGKVSTLMHDGVDVDSVVEVTAPMGDFTLNRHATTPVVLISGGVGITPMMSMASTLVAAGSEREVRFLHACRAANVHAFRDWLNDTTDAHPNVKRAVFYEVVGPNDRVGVDHDHEGRITPAALERHALVPDADYYICGPIAFMKQQRDALVALGVAPERVQTEIFGSGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R95</accession>
    <name>Q63R95_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Putative tyrosine-protein kinase involved in EPS biosynthesis</fullName>
            <ecNumber evidence="20">2.7.1.112</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">BPSL2778</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.112" evidence="20"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532211.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109373.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2778"/>
    <dbReference type="EnsemblBacteria" id="CAH36787">
        <property type="protein sequence ID" value="CAH36787"/>
        <property type="gene ID" value="BPSL2778"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2778"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2535"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYGYNHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005700">
        <property type="entry name" value="EPS_ExoP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01005">
        <property type="entry name" value="eps_transp_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="17">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="19">
        <location>
            <begin position="390"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="18">
        <location>
            <begin position="547"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="291"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAH36787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="746" mass="80342" checksum="AD801C52D05B2688" modified="2004-10-25" version="1">MNPNPTGTSTPADSEGDTDFIAVLDILIEGRWLIAAIALGVFIVGVAYAVFSKPVYQADILIQVEDSPDTSAAKSLLGDVSSLFDVKSSAAAETQILASRLVVSRAVDNLKLFIDAKPKRFPVIGHWLARRSEGLSDPGLAGFGGYAWGQERIDVATFDVPRAMEGDTFELTMLDARRYRLDGGDLERGAVGVVGRLERIAAKGGPIALRVDAFAAKPGATFVLVRHSRLRTIEALQDNLDVQERVKQSDVVVASLRDTDPDLVSRALNEIGRQYIAQNIQRKSAEAAQSLEFLNGQLPTLKQQLTDSEARLTKLRDEHGSVDLTEEAKLVLAQSADAKTRLLELQQKRRELLSRFMPKHPSVVAIDQQIAALDGYRGTAEQQIKRLPALQQQFVRLMLDVKVNTDLYTALLNNMQQLQLVRAGKVGNVRLVDTAAVPEVPVKPKKALVALASLLLGVLAGCGTAVGRSMLFHGISDPNEIERRLGLSVYATVPRSDRQRALTERAKHKARALSLLCVAHPDEPAVESLRSLRTALQFAMLDAKNNVVVIAGPAPGVGKSFVSANLAAVLTMAGKRVLLIDGDIRKGHLNDYLGLARGKGFSELIAGSAQPDDVLHRDVIAGLDFISTGAMPKNPAELLLNARVSTLIDTFSQRYDAVVIDSPPVLAVADTGILAATAGTAFLVTLAGSTKLGEIAESAKRLAQNGVRLSGVVFNGINPRLGQYGYGSKYGGYRYVAYEYGAKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RB3</accession>
    <name>Q63RB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185593.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109355.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2759"/>
    <dbReference type="EnsemblBacteria" id="CAH36767">
        <property type="protein sequence ID" value="CAH36767"/>
        <property type="gene ID" value="BPSL2759"/>
    </dbReference>
    <dbReference type="GeneID" id="56594914"/>
    <dbReference type="KEGG" id="bps:BPSL2759"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2556"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="26161" checksum="FC731A8C9BE7C8C2" modified="2004-10-25" version="1">MIVFVTGASAGFGAAIARAFVQGGHRVVAAARRKERLDALAAELGSALLPIELDVRDRAAVEAVAAALPTEFAAIDVLVNNAGLALGVEPAHRASLDEWQTMIDTNCTGLVTVTRALLPGMVERGRGHIFNLGSVAGSYPYPGGNVYGATKAFVRQFSLNLRADLIGTPLRVTDIEPGLCGGTEFSNVRYRGDDEKAANVYANVQPLTAEDIADTIYWIATRPAHVNINTIEMMPVAQAPAGLAVHRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RL2</accession>
    <name>UREE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureE</name>
        <name type="ordered locus">BPSL2660</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreE family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205202.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109256.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RL2"/>
    <dbReference type="SMR" id="Q63RL2"/>
    <dbReference type="STRING" id="272560.BPSL2660"/>
    <dbReference type="EnsemblBacteria" id="CAH36668">
        <property type="protein sequence ID" value="CAH36668"/>
        <property type="gene ID" value="BPSL2660"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2660"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2684"/>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYDARCK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00571">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0996">Nickel insertion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223409" description="Urease accessory protein UreE">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="205" mass="22133" checksum="122489EF071C095A" modified="2004-10-25" version="1">MRTIDKRIAPNVRLAATLVARAPALTLAYDARCKSRLAATLDTGEDVALVLPRGTVLRDGDVLVADDGALVRVAAAHEAVLLVRAPDALTLTRAAYHLGNRHTPVEVGAGCLKLEYDPVLADMLTRLGATVERASAPFQPEAGAYGGGHRHGHDATFAEDYALAQQVFDEHHGHSHSHDHDHDHDHDHDHQHGPCCSHGHHHGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RV2</accession>
    <name>Q63RV2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Lysozyme</fullName>
            <ecNumber evidence="2 6">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 24 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109165.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2568"/>
    <dbReference type="EnsemblBacteria" id="CAH36576">
        <property type="protein sequence ID" value="CAH36576"/>
        <property type="gene ID" value="BPSL2568"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2568"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2932"/>
    <dbReference type="eggNOG" id="COG3772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAYYNDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4 6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="171" mass="18950" checksum="FF84AD5FD40FF943" modified="2004-10-25" version="1">MRGRQMANENMRLSQAGWTALRIREHAVMAYYNDAANNCTYGVGTLAHTGPCTPDERARPVTEAQVNAQLATRVSRAEAAVRRNVTTRELTQDQFDELVSYTYNAGDTGARAALQAANLSNDAGVVSHMNQRVYIHPRDANGRRLAPVRSNGLVNRRRLETAPFRRQPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW0</accession>
    <name>Q63RW0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor GreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Transcript cleavage factor GreB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">greB</name>
        <name evidence="7" type="ordered locus">BPSL2560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GreA/GreB family. GreB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185709.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109157.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2560"/>
    <dbReference type="EnsemblBacteria" id="CAH36568">
        <property type="protein sequence ID" value="CAH36568"/>
        <property type="gene ID" value="BPSL2560"/>
    </dbReference>
    <dbReference type="GeneID" id="56594901"/>
    <dbReference type="KEGG" id="bps:BPSL2560"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2804"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DQIFFGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00930">
        <property type="entry name" value="GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006358">
        <property type="entry name" value="Tscrpt_elong_fac_GreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01461">
        <property type="entry name" value="greB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="5">
        <location>
            <begin position="107"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="20732" checksum="333FAEF6A289DB8C" modified="2004-10-25" version="1">MNKAFVKESDGDDDDLDFAQAAIPPGAKNYITPAGHKRLRDELLHLIDEARPDVVKLVSWAASNGDRSENGDYIYGKRRLREIDRRIRFLTKRLDLAEVVDASRQENADQVFFGATVDYATQDGNEHTVTIVGVDEVDLDRGHVSWISPVARALLKARVGDTVTLLTPVGPEPIDVLDVRYPPPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW9</accession>
    <name>Q63RW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539816.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109148.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2551"/>
    <dbReference type="EnsemblBacteria" id="CAH36559">
        <property type="protein sequence ID" value="CAH36559"/>
        <property type="gene ID" value="BPSL2551"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2551"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2817"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPRTVWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267488" evidence="1">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="17958" checksum="F38F7B29080ED0AD" modified="2004-10-25" version="1">MKRVAFALAALAVLANAAPGAAQEGRLPQPLRATDVASLYASGSGAPLVVEVWSLDCGYCRENAAHLVEWQRRHPQVRVALVALDSLDEHGQELAGALAQMKLPAAVRQYANAEPMPERLRAALDPRWRGELPRTLWIGEDGTRRAKSGLLAPAVLDAWLQRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RY9</accession>
    <name>Q63RY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109128.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2532"/>
    <dbReference type="EnsemblBacteria" id="CAH36539">
        <property type="protein sequence ID" value="CAH36539"/>
        <property type="gene ID" value="BPSL2532"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2532"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2885"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTAHPYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="555" mass="61073" checksum="952F892DC49E11E8" modified="2004-10-25" version="1">MRIDEVLMAVVPLSTPPVLIVGAGPTGLAAALCLARARVPVRIVDKAARPARYSRAIGIQARTLELLEQQRVVDRFVELGHRARLAILYSAGQRIAELDFDPLQTRYPYLLFLDQTVTERLLTEHLATFDVHVERGVTLTHCAQPEGALDVRLRHGDGRDERLQPSYVVAADGARSTVRHLLDVDFVGHAFEQTFMLADLELGADWPDDEIHLFTTGEGLAGLFPMGGGRYRLVADRPPRNGALDDEREPSLELCREVVRARVTPDLKVGDLAWSSYFHLHSRMVARLRVGRVFFAGDAAHVHSPAGAQGMNTGIQEAFNLGWKLARVLAGNAPERLLETYHAERHPIERDVLRQTSFATQVVEADRGPLKLLRDHIVPILASFGPLRDAARRTVSELAIQYRKSPLTLERVLDGGPRAGERAPDALVHVLDGPLGKAPGVARLFDLHDPAHFTLLVLEPREAIDDTLPSDPGEDGRALAGALERIMPGAVRCWCATDAEGEGAPLLADAYGRARPVFYLLRPDGYVAARGRPATDANALLRHCETWFSGMRLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ3</accession>
    <name>Q63RZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent formate dehydrogenase gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fdsG</name>
        <name evidence="4" type="ordered locus">BPSL2528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109124.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2528"/>
    <dbReference type="EnsemblBacteria" id="CAH36535">
        <property type="protein sequence ID" value="CAH36535"/>
        <property type="gene ID" value="BPSL2528"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2528"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2880"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHVQGAE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="171" mass="18278" checksum="37D7A5F38425C778" modified="2004-10-25" version="1">MNHKRIYDCGGGNRMSPHSVAPDALVRAHAQPGRSLVAILHAIQDDAGYVPPACVEPLAKALNLSRAEVHGVLTYYHHFRTAPPAHVTIRLCRAEACRSMGGEALVAHAQARAGCRIDGGHGDRVALESVYCLGLCAQSPSLTINDEPHAKMSPARFDALFDAAVRTKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S02</accession>
    <name>Q63S02_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="9">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="9">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">serC</name>
        <name evidence="12" type="ordered locus">BPSL2519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="9">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9 10">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189993.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109115.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2519"/>
    <dbReference type="EnsemblBacteria" id="CAH36526">
        <property type="protein sequence ID" value="CAH36526"/>
        <property type="gene ID" value="BPSL2519"/>
    </dbReference>
    <dbReference type="GeneID" id="56596440"/>
    <dbReference type="KEGG" id="bps:BPSL2519"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2862"/>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYRASMY"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7 9" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="9 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="11">
        <location>
            <begin position="3"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="360" mass="39425" checksum="8CEA1B9BF2B78B96" modified="2004-10-25" version="1">MRVFNFSAGPAAMPEEVLRQAAAEMLDWNGSGMSVMEMSHRGKEFMSIHEAALADLRELLGVPANYRILFLQGGGIAENAIVPMNLLGSRTTADFVITGSWSQKSFNEAKKYCVPHLAATGKTDAGFTRVPAFSEWRMSDDPAYVHLCTNETIDGVETFDIPDLGNVPLVADVSSHILSRPIEIEKYGAIFGGAQKNIGMAGVTLVIVREDLLDRALSICPSAFEWKTVALNNSLYNTPPTYAIYIAGLVFKWLKAQGGLAAIEARNIEKSKLLYDAIDASGFYLNKVEKPARSRMNVPFFLADESRNEDFLAGAKERGLLQLKGHKSVGGMRASIYNAVPLAGVQALVEYMKDFERRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SB2</accession>
    <name>Q63SB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCO1/SenC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203008.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109004.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2412"/>
    <dbReference type="EnsemblBacteria" id="CAH36415">
        <property type="protein sequence ID" value="CAH36415"/>
        <property type="gene ID" value="BPSL2412"/>
    </dbReference>
    <dbReference type="GeneID" id="56596324"/>
    <dbReference type="KEGG" id="bps:BPSL2412"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2981"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNYEVTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="50"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="219" mass="23947" checksum="9F64BCE67CB61DD2" modified="2004-10-25" version="1">MPFPFFTARAQAASSPASARRTRFLRFAAACAAAAALAGCTPRGEPWRLANVTGHLPDLTFSLTGEDGRPIDASAFRGRAALVYFGYTHCPDVCPETMARLMRVLALLSPQARSEVRILFVSVDPARDTPAAMRDYVGAFDAEHAYGLTGSERQIESLAKRYRVAYQMEKRDPNGSYEVTHSSAVYVFDAQGRARLLATDQDSPDAIAADLRRIIVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SH2</accession>
    <name>Q63SH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative DNA photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533992.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108944.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2349"/>
    <dbReference type="EnsemblBacteria" id="CAH36352">
        <property type="protein sequence ID" value="CAH36352"/>
        <property type="gene ID" value="BPSL2349"/>
    </dbReference>
    <dbReference type="GeneID" id="56528837"/>
    <dbReference type="KEGG" id="bps:BPSL2349"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3065"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQWSASS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="486" mass="52814" checksum="4A740820FD0D8599" modified="2004-10-25" version="1">MSSSISIAPAVVWFRDDLRVSDHPALMRAAESGRPVIGVYVFDERAGGRPLGGAARWWLHGSLRALGAALAALGGTLALLRGDEHDTIVSFAAALGAGAVYWSRRYALAARAVDNAVQTALDAQGIAVETFNASLLFEPGDLVNADGRPYQVFSAYWRAAMRRGVPAPPLGAPRRLNGGALPAALARQCVALDALGLEPTGPDWAGGLRDAWRFGEDAAHRRLRAFVDSRLGGYAAERDRPGIASTSRLSPYVRFGNLSARQLWHAAADAYAHGAATQADLDKFLSELGWREFGWTQLHHFPDLPRRNLRHTLDGMPWRDDPAALAAWRRGATGYPFVDAGMRELWATGWMHNRVRMVCASFLVKHLLIDWRAGEAWFWDTLVDADAASNAANWQWVAGCGADAAPYFRIFNPVAQGRKFDPDGAYVRRWVPELAGLPPATIHEPWAAPGAQLAAAGVRLGETYPLPIVAHDAARRRALDAFGAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SK2</accession>
    <name>Q63SK2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine synthetase</fullName>
            <ecNumber evidence="5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA</name>
        <name evidence="7" type="ordered locus">BPSL2318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192601.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108914.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2318"/>
    <dbReference type="EnsemblBacteria" id="CAH36321">
        <property type="protein sequence ID" value="CAH36321"/>
        <property type="gene ID" value="BPSL2318"/>
    </dbReference>
    <dbReference type="GeneID" id="56596117"/>
    <dbReference type="KEGG" id="bps:BPSL2318"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3106"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="104"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="471" mass="52189" checksum="05A48454D2858168" modified="2004-10-25" version="1">MSKTVADVMQLAKDEDVKFVDFRFTDTRGKEQHVSVPVSAFGEDKFESGHAFDGSSIAGWKGIEASDMLLMPDPNAAFIDPFYEESTLVLTCDVVEPADGKGYERDPRSLAKRAEAYLKSTGIGDTAYFGPEPEFFIFDSVQWNTDMSGCFVKINSEEAPWSSAKEFEGGNTGHRPGVKGGYFPVAPVDQFQDMRSEMCLLLEQIGIPVEVHHHEVAGQGQNEIGTKFSTLVERADWTQWAKYIIHNVAHSYGKTATFMPKPVVGDNGSGMHVHQSIWKDGQNLFAGNGYAGLSETALFYIGGIIKHARALNAITNPTTNSYKRLVPHFEAPVKLAYSARNRSASIRIPHVSNPKGRRIETRFPDPMANPYLCFSALMMAGLDGIQNKIHPGEAADKNLYDLPPEEDAKIPTVCAGLDQALEALDKDREFLTRGGVFTDAMIDAYLGLKEQELAKFRMTTHPIEFEMYYSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T42</accession>
    <name>GUAA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="1">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">guaA</name>
        <name type="ordered locus">BPSL2127</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108724.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T42"/>
    <dbReference type="SMR" id="Q63T42"/>
    <dbReference type="STRING" id="272560.BPSL2127"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="CAH36130">
        <property type="protein sequence ID" value="CAH36130"/>
        <property type="gene ID" value="BPSL2127"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2127"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2416"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0332">GMP biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229412" description="GMP synthase [glutamine-hydrolyzing]">
        <location>
            <begin position="1"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GMPS ATP-PPase" evidence="1">
        <location>
            <begin position="211"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="238"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <sequence length="547" mass="60174" checksum="2E14E7FDA5F8A90C" modified="2004-10-25" version="1">MFLSPSAAMHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPGPGLGVRILGEVKRDYAELLRRADAIFIEELCGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TG1</accession>
    <name>Q63TG1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205106.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108605.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2007"/>
    <dbReference type="EnsemblBacteria" id="CAH36006">
        <property type="protein sequence ID" value="CAH36006"/>
        <property type="gene ID" value="BPSL2007"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2007"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4161"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FVWPIFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010645">
        <property type="entry name" value="MFS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06779">
        <property type="entry name" value="MFS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_4" evidence="3">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_4" evidence="3">
        <location>
            <begin position="358"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="564" mass="55942" checksum="26F4653BDB13766B" modified="2004-10-25" version="1">MSSLPSFLAAASGPRGPSHDQRAACRAALAGAVALAVALGVGRFAFTPLLPLMLAGGELDIRHGGWLASANYAGYFVGAMTCARIAVDPARMVRAGLAATVLLTFAMGLASPFWVWALVRFVGGAVSAWTFVFASQWGLRRVVEHGAPAWGGVIYTGPGIGIVATGLIGFALAGRHAALGWIGFAAASAVLTAFVWRAFGAAGAGTDGGQSRGGAKRAGDGVGVADAAGRAGERLAAGAAEGAGAVADAVSAANVADTADTADTANTANTANTANTANTANTANTANTANTANTANTANTANTANTANTANTANTANTANSANSANSANSANSANSATATAERNSPVAGVAGQHGAMAAPAARAPHVESAAARRDAFWLVLLYGLPGFGYIITATFLPVIARAALPAHSRWPDLFWPMFGAALIAGALLGARLPSGWDNRLLLGACCAVQALGVALGIVWPTAPGFALGSALVGLPFTAITLFAMREARRLRGERAAGLMGYATASYGVGQIAGPLAAAPLAAHAGSFSPALWLAATMLAVGAAGFAAVALRAWRAKTRGGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TL5</accession>
    <name>Q63TL5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550570.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108551.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1953"/>
    <dbReference type="EnsemblBacteria" id="CAH35952">
        <property type="protein sequence ID" value="CAH35952"/>
        <property type="gene ID" value="BPSL1953"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1953"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4098"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTVLYLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="24329" checksum="48B61C2489DFF942" modified="2004-10-25" version="1">MQASFNDQRVLVIGGSSGIGAAAARAFAVLDADVTIASRDANKLAAAARAIDGPRPVRQAVLDTTDAPAVDAFFAEAGPFDHVVMSAAHTPGGPVRKLPLADAQAAMDSKFWGAYRVARAARIAPGGSLTFVSGFLSVRPSASAVLQGAINAALEALARGLALELAPVRVNTVSPGLVATPLWSKLGDAAREAMYASAAARLPARRVGQPEDIANAIVYLAATRYATGSTVLVDGGGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TR7</accession>
    <name>Q63TR7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbriae assembly related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108499.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1899"/>
    <dbReference type="EnsemblBacteria" id="CAH35899">
        <property type="protein sequence ID" value="CAH35899"/>
        <property type="gene ID" value="BPSL1899"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1899"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4042"/>
    <dbReference type="eggNOG" id="COG3847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AINAKFT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007047">
        <property type="entry name" value="Flp_Fap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04964">
        <property type="entry name" value="Flp_Fap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="56" mass="5796" checksum="C251A03C45DA34CA" modified="2004-10-25" version="1">MKQLMHRFFKEEAGVTAIEYGLIAGLIAVAIATTVGTVGTDLSALFSTIASKLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U03</accession>
    <name>Q63U03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526913.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108413.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1814"/>
    <dbReference type="EnsemblBacteria" id="CAH35813">
        <property type="protein sequence ID" value="CAH35813"/>
        <property type="gene ID" value="BPSL1814"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1814"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3935"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLNWQRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="162"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="331" mass="35336" checksum="720E92615389D701" modified="2004-10-25" version="1">MSAADVVAVGAFFAIVVAGFIVRALRDLARRRPAARVRSRVEALREPRAAARPAAPARASRVGLQLFTRTHGEGEGGALRAWLRARGEHVRTAAGGGGVRAIAFASALAALAGFVGASFAGFAPWLRLALAAALAAGAARAVYRILIGRFKQRFLSVFPDALDLIIRAVRAGIPVAQAIGTAGRESEEPVRATFRAMGDALRVGADLKDVLEQQAERLQLADFSFFGVCLVLQRETGGNLTETLENLSGIIRTRRDIRMKTRALTAEGRIASKIIAAVPFAIAGFLFVVNRPYVNLLFHTRAGHKMLILAAVLLTVGLAMIRKIANLDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U13</accession>
    <name>Q63U13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug efflux system putative membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">amrA</name>
        <name evidence="3" type="ordered locus">BPSL1804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521590.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108403.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1804"/>
    <dbReference type="EnsemblBacteria" id="CAH35803">
        <property type="protein sequence ID" value="CAH35803"/>
        <property type="gene ID" value="BPSL1804"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1804"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3923"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFRIMPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="60"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="399" mass="42507" checksum="E545D26FD733A997" modified="2004-10-25" version="1">MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKARAAHLAALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASARAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQQDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTADSATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U47</accession>
    <name>Q63U47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cobalamin biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobW</name>
        <name evidence="3" type="ordered locus">BPSL1769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538305.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108369.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1769"/>
    <dbReference type="EnsemblBacteria" id="CAH35768">
        <property type="protein sequence ID" value="CAH35768"/>
        <property type="gene ID" value="BPSL1769"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1769"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3874"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IDVENWE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012824">
        <property type="entry name" value="Cbl_biosynth_CobW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02475">
        <property type="entry name" value="CobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="259"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="357" mass="38622" checksum="A4221517FD417231" modified="2004-10-25" version="1">MQMRKIPVTIVTGFLGSGKTTLLRHILQHAGGRRIVVIVNEFGELGIDGEILKGCGVGCDEAGREVDGRLYELANGCLCCTVQEEFYPVMEQLVERRAHIDHVLIETSGLALPKPLVQAFNWPSIKNGFTVDAVLTVVDAPATARGQFAENPAAVDAQRRADPNLDHESPLHELFADQLSSADLVIVNKTDLLDDAALAAVEATIRDEVPPQVKLVRARRGELDLATLLGLNAASEETIHLRHDHHGSADDADHHHDEFDSVVVEARVSSREAALGALGALVEAHAIYRVKGFAALPGVPMRLVVQGVGRRFDSYFDRRWRDGEAPASRFVLIGEDLDAAALQRAFDAALAAHGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U64</accession>
    <name>Q63U64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192716.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108352.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35751">
        <property type="protein sequence ID" value="CAH35751"/>
        <property type="gene ID" value="BPSL1752"/>
    </dbReference>
    <dbReference type="GeneID" id="56595537"/>
    <dbReference type="KEGG" id="bps:BPSL1752"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3852"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WEFDVLT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="17902" checksum="C25F4A9476229E62" modified="2004-10-25" version="1">MDRAAHAVEQWRRERPDLDPSPMIVLGRLQEAALVIARDRLNPLFARYGLQPGEFDVLATLRRSGAPYALTPTALYDAAMISSGSMTNRIDRLEKAGWVERRPNPADGRGTLVALTPAGLALIDDAVVAHVGNQQRALSALSDAEQRQLAKLLGKLLQGQADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UC4</accession>
    <name>Q63UC4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family M20 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521485.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108292.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1682"/>
    <dbReference type="EnsemblBacteria" id="CAH35681">
        <property type="protein sequence ID" value="CAH35681"/>
        <property type="gene ID" value="BPSL1682"/>
    </dbReference>
    <dbReference type="GeneID" id="56529382"/>
    <dbReference type="KEGG" id="bps:BPSL1682"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3762"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VGEFRIE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="426" mass="44997" checksum="9E61C68400692C84" modified="2004-10-25" version="1">MNPTVFPPLNAERLNARVEQLARFTRADVPWTRRAFSPLFTEARAWLAAQFAAAGLAVSMDAAGNLIGRREGSGRCTKPLITGSHCDTVVGGGRFDGIIGVLAGIEVAHTLNEQGIVLDHPLEVIDFLSEEPSDYGISCVGSRALSGVLDAGMLRATNGEGETLAQALTRIGGKPEALNMPLRAPGSTAAFVELHIEQGPVLEARGLPIGVVTNIVGIRRVLITVIGQPDHAGTTPMDIRRDALVGAAHLIEAAHARALSLSGNPHYVVATIGRIAMTPNVPNAVPGQVELMLEVRSDSDAVLDAFPETLLAGAAAQLDALRLSAHAEHVSRARPTDCQPLVMDAVEQAAAQLGYPSMRLPSGAGHDAVYVAPTGPIGMIFIPCLGGRSHCSEEWIEPQQLLDGTRVLYRTLVVLDRTLAAHETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UJ7</accession>
    <name>Q63UJ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547269.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108219.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1603"/>
    <dbReference type="EnsemblBacteria" id="CAH35603">
        <property type="protein sequence ID" value="CAH35603"/>
        <property type="gene ID" value="BPSL1603"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1603"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3662"/>
    <dbReference type="eggNOG" id="COG4314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASAFYVY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008719">
        <property type="entry name" value="N2O_reductase_NosL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41247">
        <property type="entry name" value="PTHR41247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05573">
        <property type="entry name" value="NosL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266341" evidence="1">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="176" mass="19069" checksum="2038E6A0D024BEFB" modified="2004-10-25" version="1">MKRRFLSAAVRTSIAALASAALVAACGHDAQTPPPAREITDATVSVLDGMSLKDYPGPKAQIVYADGEPDFFCDTLGLFSVYLRPEHDRKVRALYVQDMGATDWQHPVGHWIDAKRAIYVIGSKKPGAMGRTFASFAREADAARFAKAEGGKLYRFGEITPEMATTDGGVVKDQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UW3</accession>
    <name>Q63UW3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191066.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108103.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1483"/>
    <dbReference type="EnsemblBacteria" id="CAH35484">
        <property type="protein sequence ID" value="CAH35484"/>
        <property type="gene ID" value="BPSL1483"/>
    </dbReference>
    <dbReference type="GeneID" id="56595780"/>
    <dbReference type="KEGG" id="bps:BPSL1483"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3515"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQEAFYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="17776" checksum="60FE7B422331CD6E" modified="2004-10-25" version="1">MRLTDYTDYSLRVMLFLAVRGEGLSTIQEISDAYGISKNHLMKVVQQLGELGWIETVRGRNGGLRLNAQSVTLTVGEVVRKTENDFALVGCFAGESESHRSCVIQSACRLRGVFAAAREAFFAELDKHTIGELAQPASQLATLLGLAPVRIVSAADIRAAAPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V55</accession>
    <name>Q63V55_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108011.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1387"/>
    <dbReference type="EnsemblBacteria" id="CAH35388">
        <property type="protein sequence ID" value="CAH35388"/>
        <property type="gene ID" value="BPSL1387"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1387"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1556"/>
    <dbReference type="eggNOG" id="ENOG5033NU3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DARGYVE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="149" mass="16305" checksum="88342B924FE7213F" modified="2004-10-25" version="1">MAGLAQIDERGFVERVRQDLVKENPAFADDGGLSSRLWTAYRAARALGIERDENVVAFLRLEAYAPGFYEKPATKAWLTRPGRSADARFHDYLRVIKWRIEHPDGGLEHGGIGISGNRSGGGGAWADLGARWRRLVGRRDGGGNGESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VE7</accession>
    <name>Q63VE7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107919.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1297"/>
    <dbReference type="EnsemblBacteria" id="CAH35292">
        <property type="protein sequence ID" value="CAH35292"/>
        <property type="gene ID" value="BPSL1297"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1297"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1443"/>
    <dbReference type="eggNOG" id="COG4705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RREIFYW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="27081" checksum="5F7E2862ED4EB9D7" modified="2004-10-25" version="1">MNQPARSPAVAGMLNKVPEVTLAFWIVKIMSTTVGETGADYLAVHVGLGAAVTGALTACLLVGALALQWRARAYVPWIYWLNIVLVSVAGTQITDALTDGLGVSLHVSTPLFAAALAATFALWYRSERTLSIHTIVTPRREGFYWAAILLTFALGTAAGDLATEALGLGFRLGIVAFGGAIALVAAAALGGMNRVLAFWLAYILTRPLGASLGDFLSQAQAYGGLGLGTIRTSAVFLAVIVALVAGLSVAAARAGRLGARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL8</accession>
    <name>Q63VL8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526464.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107848.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1226"/>
    <dbReference type="EnsemblBacteria" id="CAH35221">
        <property type="protein sequence ID" value="CAH35221"/>
        <property type="gene ID" value="BPSL1226"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1226"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.300"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="196" mass="21982" checksum="B0A6B00483C7C68F" modified="2004-10-25" version="1">MADLPNHDATLTETCIESESVYDGAFLKVKRDTVRLPDGKHATREYVTHPGAVMVIPLFDNGRVLMESQYRYPIGKVMAEFPAGKLDPNEGALACAVRELREETGYTAREYVFLTRIHPIISYSTEFIDIYLARGLTAGERKLDDGEFLETFTATLPDLLEWVRTGRISDVKTIIGTMWLEKAVSGAWPLGDVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VN9</accession>
    <name>Q63VN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amino acid transport system, exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196429.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107827.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1205"/>
    <dbReference type="EnsemblBacteria" id="CAH35200">
        <property type="protein sequence ID" value="CAH35200"/>
        <property type="gene ID" value="BPSL1205"/>
    </dbReference>
    <dbReference type="GeneID" id="56595138"/>
    <dbReference type="KEGG" id="bps:BPSL1205"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.321"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VAEWHPN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266375" evidence="1">
        <location>
            <begin position="28"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="33"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="425" mass="45445" checksum="4DD018149A0CE1D2" modified="2004-10-25" version="1">MSSYWMRFAAAASAALTLALPMPFAAAAATGEPIRIALVEGMSGPFANAGAAVERNLRFGIERVNAQGGVRLRDGAHPLELVVLDSKGSVEEALVQLRAATDKGIGFVAQGNGSAVAAALVAALDRHNARDPEHRALFLNYSADDPALTGRDCSFWHFRFDAHAGMRMDALADVLARDRAVKKVYLLNQDYSFGHDVSALARAALKARRPDIAIVGDEFHPIGRVKDFSPYAAKIRASGADAVVTGNWGNDLTLLVRATREQGLAAKFYTFYGNSLDAPAALGDAGVKRVLAVADWHPNAGGARSDAFYRAFRARFPAAQDDYPVRRMSEMIEMLAAAMTRAGSADPVAVAKALEGMRYDDGFHPAQMRAADHQLIQPLYVIEMERAGAPGVRFDNAGSGYGFATVLEAPPTQGAAPAECRMKRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VP3</accession>
    <name>LEU1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="1">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuA</name>
        <name type="ordered locus">BPSL1201</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522419.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107823.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VP3"/>
    <dbReference type="SMR" id="Q63VP3"/>
    <dbReference type="STRING" id="272560.BPSL1201"/>
    <dbReference type="EnsemblBacteria" id="CAH35196">
        <property type="protein sequence ID" value="CAH35196"/>
        <property type="gene ID" value="BPSL1201"/>
    </dbReference>
    <dbReference type="GeneID" id="56526661"/>
    <dbReference type="KEGG" id="bps:BPSL1201"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.326"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000149155" description="2-isopropylmalate synthase">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01151"/>
        </source>
    </evidence>
    <sequence length="515" mass="55586" checksum="E784409E21E59850" modified="2004-10-25" version="1">MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIQTIASQVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNIEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAVDGDEVAGEASGNGPVDATFNAIETEVGSGAELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLYSNADKLNPQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ4</accession>
    <name>Q63VQ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185574.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107812.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1190"/>
    <dbReference type="EnsemblBacteria" id="CAH35185">
        <property type="protein sequence ID" value="CAH35185"/>
        <property type="gene ID" value="BPSL1190"/>
    </dbReference>
    <dbReference type="GeneID" id="56595123"/>
    <dbReference type="KEGG" id="bps:BPSL1190"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.338"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERVDLWQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="344" mass="38238" checksum="8CE445891BA8EE4B" modified="2004-10-25" version="1">MKIMIVTDAWEPQVNGVVRTLKSTARELTALGHRVELVTPLEFRTVPCPTYPEIRLSILPYRRLRERLDAFEPHALHIATEGPLGLAARRYARARKLPFTTAYHTRFPEYVQARFGVPLAATYRFLRWFHGASLAVMAPTPVVKDDLERFGFDNVVLWTRGVDLDIFRPIESKVLNTARPIFLYVGRVAIEKNVEAFLKLDLPGSKWVAGEGPALAELKSRYPEANYLGVLTQAELAKVYAAADVFVFPSRTDTFGLVLLEALACGTPVAAYPVTGPVDVLGDGGAGAMNDDLREACLEALKIDRRHARAWAERFSWRAASEQFASHLKPLQKSACPHTEGAAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W75</accession>
    <name>CAPP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="1">PEPC</shortName>
            <shortName evidence="1">PEPCase</shortName>
            <ecNumber evidence="1">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppc</name>
        <name type="ordered locus">BPSL1013</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191560.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107641.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63W75"/>
    <dbReference type="SMR" id="Q63W75"/>
    <dbReference type="STRING" id="272560.BPSL1013"/>
    <dbReference type="EnsemblBacteria" id="CAH35009">
        <property type="protein sequence ID" value="CAH35009"/>
        <property type="gene ID" value="BPSL1013"/>
    </dbReference>
    <dbReference type="GeneID" id="56596175"/>
    <dbReference type="KEGG" id="bps:BPSL1013"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.555"/>
    <dbReference type="eggNOG" id="COG2352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166585" description="Phosphoenolpyruvate carboxylase">
        <location>
            <begin position="1"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="994" mass="108735" checksum="55D70FE099C4A788" modified="2004-10-25" version="1">MKSSGSARATRRNAVSSSSAPAHAEPPARRAAKPARKLDGAAARPLAPTNAASAKPQGRTREDKDRPLFEDIRYLGRLLGDVVREQEGDAVFDVVETIRQTAVKFRREDDKAAAQTLEKMLRKLTPEQTVSVVRAFSYFSHLANIAEDRHHNRRRRIHALAGSAAQAGTVAYALDKLKQAGDASSKTIKQFFEGALIVPVLTAHPTEVQRKSILDAQHDIARLLAERDQPLTARELAHNEALLRARVTTLWQTRMLRDARLTVADEIENALSYYRATFLDELPALYADIEEALAEHGLRARVPAFFQMGSWIGGDRDGNPNVTAATLDEAISRQAAVIFEHYLEQVHKLGAELSVSNLLVGASDALKALAAASPDQSPHRVDEPYRRALIGVYTRLAASARVRLGEGTVPVRSAGRGAAPVRATPYADAEEFAADLRVLTDSLALHHGESLATPRLAPLMRAAEVFGFHLASIDLRQSSDIHEAVVAELLARGGVEADYAALPEADKLRVLLAALADPRPLRSPYLDYSDLAKSELGVLERAHAIRAQFGARAVRNYIISHTETVSDLVEVLLLQKETGLFEGTLGTPHANARNGLMVIPLFETIADLRNASDIMRAFFALPGVGELLAHQGHEQEVMLGYSDSNKDGGFLTSNWELYRAELALVDLFDERGIKLRLFHGRGGTVGRGGGPTYQAILSQPPGTVNGQIRLTEQGEVIASKFANPEIGRRNLETVVAATLEATLAPHSNAPKQLPAFEAAMQTLSDAAMASYRALVYETPGFTDYFFSSTPITEIAELNIGSRPASRKLQDPKNRKIEDLRAIPWGFSWGQCRLLLTGWYGFGSAVAAYLDGAPDAAERGKRVALLKKMNKTWPFFANLLSNMDMVLAKTDLAVASRYAQLVADKKLRKHVFERIVAEWHRTADALAEITGAHARLAANPLLARSIKNRFPYLDPLNHLQVELIKRHRAGDTNARLRRGIHLTINGIAAGLRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W88</accession>
    <name>Q63W88_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193796.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107628.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1000"/>
    <dbReference type="EnsemblBacteria" id="CAH34996">
        <property type="protein sequence ID" value="CAH34996"/>
        <property type="gene ID" value="BPSL1000"/>
    </dbReference>
    <dbReference type="GeneID" id="56596189"/>
    <dbReference type="KEGG" id="bps:BPSL1000"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.569"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="38053" checksum="86900759ABA00B2B" modified="2004-10-25" version="1">MSIDRALVDAALAAVVDPNTGRPYAAHRGIRNVAIDGDAVSADVVLGYPAKSQFDDARARVAAALAAVPGVRQARVDVSQEIVAHAVQRGVQLLPNVKNIVAVASGKGGVGKSTTAVNLALALAAEGASVGMLDADIYGPSLPTMLGIHERPESPDNKSMNPLVGHGLQANSIGFLVGEDNPMVWRGPMATSALEQLLRQTNWRDLDYLIVDMPPGTGDIQLTLAQRVPVTGAVIVTTPQDIALLDAKKGLKMFEKVNIPILGIVENMSIHVCSNCGHEEHVFGAGGAERMAREYGVAVLGSLPLDIRIREQADSGAPTVAADPHGKLAERYRAIARGVAIAIAERARDMSSKFPTIVVQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WD1</accession>
    <name>Q63WD1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191986.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107585.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0957"/>
    <dbReference type="EnsemblBacteria" id="CAH34953">
        <property type="protein sequence ID" value="CAH34953"/>
        <property type="gene ID" value="BPSL0957"/>
    </dbReference>
    <dbReference type="GeneID" id="56596235"/>
    <dbReference type="KEGG" id="bps:BPSL0957"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.620"/>
    <dbReference type="eggNOG" id="COG3749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIWPNNR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008318">
        <property type="entry name" value="UCP030820"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06073">
        <property type="entry name" value="DUF934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030820">
        <property type="entry name" value="UCP030820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="180" mass="19754" checksum="1035E226FE7DBEB7" modified="2004-10-25" version="1">MALIIKNREVVDDAWQLVRAAEDGTLPAPDALPAGQVLVPLALWQTARDALAASRTKDALGVWLSPDSEPADLAADFDRIAVIGVEFPRFADGRGYSIARLLRERHGWKGELRAIGDVLRDQLLYMSRCGFDAFAVRADKDVRDALNAFGEFSQRYQGAFDEPAPLFRRRAAAAEAKVSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WL4</accession>
    <name>Y877_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein BPSL0877</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL0877</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196455.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107502.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WL4"/>
    <dbReference type="SMR" id="Q63WL4"/>
    <dbReference type="STRING" id="272560.BPSL0877"/>
    <dbReference type="EnsemblBacteria" id="CAH34869">
        <property type="protein sequence ID" value="CAH34869"/>
        <property type="gene ID" value="BPSL0877"/>
    </dbReference>
    <dbReference type="GeneID" id="56594748"/>
    <dbReference type="KEGG" id="bps:BPSL0877"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.719"/>
    <dbReference type="eggNOG" id="COG2835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELICHAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005735">
        <property type="entry name" value="Znf_LSD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000291075" description="UPF0434 protein BPSL0877">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <sequence length="68" mass="7409" checksum="8A37D400637FE7D7" modified="2004-10-25" version="1">MDARLLEILVCPICKGPLHYDRGAQELVCHADKLAYPIRDGIPVMLVDEARQTVEGTPVDPAGPARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WV5</accession>
    <name>Q63WV5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">moaC</name>
        <name evidence="7" type="ordered locus">BPSL0786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535462.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107411.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0786"/>
    <dbReference type="EnsemblBacteria" id="CAH34778">
        <property type="protein sequence ID" value="CAH34778"/>
        <property type="gene ID" value="BPSL0786"/>
    </dbReference>
    <dbReference type="GeneID" id="56527035"/>
    <dbReference type="KEGG" id="bps:BPSL0786"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.821"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="17403" checksum="C2DBD8AF8741A50F" modified="2004-10-25" version="1">MSGSGFTHFDAAGHAHMVDVGDKQETRRIAVARGAIRMLPDTLALIRDGRAKKGDVLGVARIAAIQGAKRTADLIPLCHPLALTRVAVDFEFDDALPGVRCSAQVETLGRTGVEMEALTAVQVGLLTVYDMCKAVDRGMTITDVSVREKRGGKSGDWKADEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X10</accession>
    <name>Q63X10_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Family S45 unassigned peptidase</fullName>
            <ecNumber evidence="7">3.5.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.11" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107356.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0730"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="EnsemblBacteria" id="CAH34722">
        <property type="protein sequence ID" value="CAH34722"/>
        <property type="gene ID" value="BPSL0730"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0730"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.800"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EMDVRRH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008953">
        <property type="term" value="F:penicillin amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="833" mass="89452" checksum="2D7590F79CC2DCC1" modified="2004-10-25" version="1">MTDTDERRMPPNRPAARVAGDLAGGRRAGATHGLAQTMASTRNRTRRHLKILSGLILCCALLALVLAAAYLRASLPQLDGELRAPVLGAPMTAERDALGVPTITARDRFDAAYGIGYLHAQDRFFQMDMLRRSGAGELSELFGPIALGVDRDHRLYRFRALAAAAVAHLPPDDLRLLQRYTQGVNDGLAALRARPFEYALLRMQPQRWRPEDSLLVIWAMYFDLQGRLASREFARHWLQAHSTPEQLAFLLPPSSRFDAPLDAPGIAAAAAPVSATAPAWLRDARPATSVNGVSIDGQSAVGSNNWALAGSRTASGAAIVGDDMHLSFGLPNIWYRAMFKLGGGAGPAARVVGVTLPGLPAVVVGSNGRIAWGFTNGYADCLELLPLERDARDPSRFRLGGAWQRARETVETIRVHGAAPVELTVLDTTAGPVREIGGKAYAAHWIAQASGAANLAFAKMIEATGVEEAIGIAAGAGLPAQNVVIGDSTGRIGWTVAGALPDRRAPGEAGARGDGAPSWRAALPPDAHPRIVDPAGGQLWTANNRQLAGDAYRLIGDGGADLGARARQLRDGLTALERPDERAAYRLDLDDRALFMSLWRDRALRVLDEAALAGHPARAEFRRLLASGWTGRASVDSVGYTLARGYLYRLYDVLFGGLDARLKQQQHDADYALANRRWPVVIARLLDEQPPGWLPADAASWRDVQLAAIDRTIDALSANGAPLADAAWGRRNTLRIAHPFARSVPLVGRWLTAPADPVPGDANMPRVAAPRFGQSERLVVSPGREESGLFNMPGGQSGHPLSPFFLAGHEAWVKGEPLPLLPGPTEHTLRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X37</accession>
    <name>Q63X37_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189643.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107329.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0700"/>
    <dbReference type="EnsemblBacteria" id="CAH34693">
        <property type="protein sequence ID" value="CAH34693"/>
        <property type="gene ID" value="BPSL0700"/>
    </dbReference>
    <dbReference type="GeneID" id="56596604"/>
    <dbReference type="KEGG" id="bps:BPSL0700"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.917"/>
    <dbReference type="eggNOG" id="COG3791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHCGRIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="115" mass="12675" checksum="FE3F946F3092E0F2" modified="2004-10-25" version="1">MLYTGSCHCGKVRFEVEGEIDGACACNCSMCARKGSLLWFVPRDALRLQTPDEDIATYLFNKHVIRHRFCPTCGIHPFAEGTDPKGNAMAAVNLRCVDGVDLDALSVRHFDGRAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X76</accession>
    <name>RSMA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name type="ordered locus">BPSL0661</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-12" db="PDB data bank">
            <title>The structure of the ribosomal RNA small subunit methyltransferase A from Burkholderia pseudomallei.</title>
            <authorList>
                <consortium name="Seattle structural genomics center for infectious disease (SSGCID)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189099.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107290.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3UZU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.75 A"/>
        <property type="chains" value="A=1-275"/>
    </dbReference>
    <dbReference type="PDBsum" id="3UZU"/>
    <dbReference type="AlphaFoldDB" id="Q63X76"/>
    <dbReference type="SMR" id="Q63X76"/>
    <dbReference type="STRING" id="272560.BPSL0661"/>
    <dbReference type="EnsemblBacteria" id="CAH34654">
        <property type="protein sequence ID" value="CAH34654"/>
        <property type="gene ID" value="BPSL0661"/>
    </dbReference>
    <dbReference type="GeneID" id="56596644"/>
    <dbReference type="KEGG" id="bps:BPSL0661"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.959"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000101503" description="Ribosomal RNA small subunit methyltransferase A">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="88"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="137"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="146"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="163"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="172"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="3UZU"/>
        </source>
    </evidence>
    <sequence length="275" mass="30247" checksum="BAA24F32D1C0985F" modified="2004-10-25" version="1">MSNSRQHQGHFARKRFGQNFLVDHGVIDAIVAAIRPERGERMVEIGPGLGALTGPVIARLATPGSPLHAVELDRDLIGRLEQRFGELLELHAGDALTFDFGSIARPGDEPSLRIIGNLPYNISSPLLFHLMSFAPVVIDQHFMLQNEVVERMVAEPGTKAFSRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPHAPHELPAVDPAVLGEVVTAAFSQRRKMLRNTLGGYRDLVDFDALGFDLARRAEDIGVDEYVRVAQAVASARASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XF8</accession>
    <name>Q63XF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936294.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107207.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34571">
        <property type="protein sequence ID" value="CAH34571"/>
        <property type="gene ID" value="BPSL0579"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0579"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1063"/>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLIDADW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="526" mass="56543" checksum="7157690ACFD50770" modified="2004-10-25" version="1">MNPFFGAQREWQDVPVPARAYARLDNLHLPHADAPDRQAALRFDLIDADWLDNQAGADNPLFDLGRPHRMRAAWKRWFAAARGGDADDPFRAAPLYVLEVSVPFDAREWRKRLGLTREAMANDAHGEILAAFRRRWYELTVLREAAARAGAMLGLLHRGIADEGLRVCCFAALAPAAHAAGLTALGTLAGSPALTSASLKPLVRDVRATYLGVYDVGQANANALLGGIRGRDLHGMVRHGVFPTLYFDLGMPLQSQRHTAPANVRFCFTAEPPIVLSHWHDDHLGGVALPTAAGCPTSQQMDWIVPDYSLATRHKALVTAIWAAGGSVHVFSASPAGRRLQAATASGHLLTLTRGTARDPNNGGIVMQVSSAQQQARRFADPPRSWLLPGDCDYKHFPSTFTPTNVIALVAPHHGADLGKGSVPVPPAAGGYLRLVYSFGRDNKYQHPRQGFVDAHHAAGWTHPVVPATGAITCVSGDDVRTTNVHSPWPAKPRGVLVGWSKAPHSVSACTLGGGATNCTLPLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XH4</accession>
    <name>Q63XH4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204821.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107191.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0565"/>
    <dbReference type="EnsemblBacteria" id="CAH34555">
        <property type="protein sequence ID" value="CAH34555"/>
        <property type="gene ID" value="BPSL0565"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0565"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1085"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CYDATDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1317" mass="147362" checksum="3571D9581CA53979" modified="2004-10-25" version="1">MSVIKQQYKSLAPKGECLSDIVVLAQAWKKSHTFIRRHNWYADVLELDCSTVDLEERLNQWADEVAQPEFSTAELLLVPAPKNARWEFKAAPDLRAVPDILDVNLDDFGSEPSFGDWVPIENGDAPSQNSSDAGQKLRPLAHVAIRDQTLATAVMMCLAEAIESHQGDTTEGDLTKLRKLGVVSYGNRLQCRWVEKGDGTKRAHFSWGNSRTYRQYFEDYRAFLSRPRRVCAELSPQTATRKELFVVSLDIKSFFDCVDSKALVHELYRLQTTYQKHEGLSENDSTDVPFWELASLILSWRWRESDHQSAPLIRGQDFEHLAVGLPQGLVASGFFANAYLVGFDTEMWRVCEEQQQLPEDIRILDYCRYVDDLRIVVEAPLAMGAAGSERTLQRVQQFVSEMLANHCLRLQANVSLTLSLQKSSITPYRSISAQSNVSSLMEALNADLSGTFDLESLVQTAGGLEGLLWMSEQIEDAPPSSRSRLALANVAVPNTDVRDDTVKRFVASRLAQVMRHRLAMTDTESPADTDVAVSDAVSAGAALSHEFEQTARKLIKCWAENPSLALLLRCGLDLFPHPRLLSPVTEALISKLPGAQNAFDSEQIKQVRTAEYVAADILRAGATETGYRDRDEYPEFVDIEGYRESLGAFARWILLEYKHAPWYLLQQVRLYLASIGDFSNIRSVNGSMEESYALLHRASLYQPVRSGELLRLLPFALVAQQLNPNPRRFGVWLAECLRRTRSEGEQAKAVTTVALNRPDLMLEALRSKTIKANGWVKHVPTPLAEVDRKLLKRGKTTDGTRTLIRCMLDNDNLFAQENGLLVLAQALLRSPDIQKRLSDGLDASQITLRCEEWEQIHSIPTATDFMKVELAPPPGTQNPLYETPLWVAEDKAWLYGLGRILRAALTGEFDFTSRRYLVTEEVGRYFGLRSTWYKRRFGMLNSGTGLLHEPTPISPWLSGLLSTLLQWPGVEFRANDAAAAGDANTPEELLALIEKRAAEQRALYGSRSRTPMYVIPASGDDAPLNERPLRVAIVQPLRPRRDDFDAKDPTHWTKGMLAEHRRHLAAVCRLAEQQLRTWASAHSKVDTDKGPLVDIVLFPELSVHPEHVGLLRRLSDKLKANVFSGLTFVHSDKVGGPINQGLWLIRSETAEHGRSIQYVWQGKLHPMKLERAMGIKPYRPHVTLVELPIGTKSPTRIAAAICYDATDLDLVADLRTKSDVFLVAALNQDVQTFDNMVAALHFHMYQPVILANSGEFGGSTAQVPLPKHERLVAHVHGSNQIAVSVFEVDPAPFKSTATPKATKELKAPPAGYKGRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XL3</accession>
    <name>Q63XL3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutY</name>
        <name evidence="15" type="ordered locus">BPSL0527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4 13"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522857.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107152.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0527"/>
    <dbReference type="EnsemblBacteria" id="CAH34516">
        <property type="protein sequence ID" value="CAH34516"/>
        <property type="gene ID" value="BPSL0527"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0527"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1121"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDPYRVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="53"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="368" mass="39897" checksum="4BB61AF2546B6CA4" modified="2004-10-25" version="1">MKPPRTPPAPPVITPLHSAFAPTLIAWQRKHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVVPYYVRFLERYPDVAALAAAPIDDVMALWAGLGYYSRARNLHRCAQAVVERHGGAFPASPEALAELPGIGRSTAAAIASFAFGARATILDGNVKRVLARVFGVEGFPGDKRIENEMWALAEALLPDAAEPTDVTAYTQGLMDLGATLCVRGKPECGRCPFAGECVAQRSGRQRELPAARPKKAVPTRRTWMLVLRDGDAVLLQRRPPAGIWGGLWSLPEADGDAALARRAREFGGAALVPLAPLTHTFTHFRLEIEPRLAELDGAAGGAPPAADDETAWVLLDRLDAYGVPAPVRKLLDGLSGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU6</accession>
    <name>Q63XU6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522910.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107069.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0444"/>
    <dbReference type="EnsemblBacteria" id="CAH34432">
        <property type="protein sequence ID" value="CAH34432"/>
        <property type="gene ID" value="BPSL0444"/>
    </dbReference>
    <dbReference type="GeneID" id="56527311"/>
    <dbReference type="KEGG" id="bps:BPSL0444"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1214"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HKAQPVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="14250" checksum="677A74B595B925F7" modified="2004-10-25" version="1">MTFFTDYTNLALIAILVVSGGLLAWPALRRGGGGLSAAEATQLINRRNALVVDLRPAAEYGAGHLPSARSVEFGELQAKAGQLAKNKATPVLLVCQNGQQSQKARKIVEEAGYQDVHVLQGGVAAWQQAGMPVVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC3</accession>
    <name>CCA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multifunctional CCA protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">CCA-adding enzyme</fullName>
                <ecNumber evidence="1">2.7.7.72</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">CCA tRNA nucleotidyltransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA CCA-pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA adenylyl-/cytidylyl-transferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA nucleotidyltransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">tRNA-NT</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">2'-nucleotidase</fullName>
                <ecNumber evidence="1">3.1.3.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">2',3'-cyclic phosphodiesterase</fullName>
                <ecNumber evidence="1">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Phosphatase</fullName>
                <ecNumber evidence="1">3.1.3.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">cca</name>
        <name type="ordered locus">BPSL0265</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Magnesium is required for nucleotidyltransferase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Nickel for phosphatase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Can also form homodimers and oligomers.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="1"/>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525896.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106892.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YC3"/>
    <dbReference type="SMR" id="Q63YC3"/>
    <dbReference type="STRING" id="272560.BPSL0265"/>
    <dbReference type="EnsemblBacteria" id="CAH34253">
        <property type="protein sequence ID" value="CAH34253"/>
        <property type="gene ID" value="BPSL0265"/>
    </dbReference>
    <dbReference type="GeneID" id="56527492"/>
    <dbReference type="KEGG" id="bps:BPSL0265"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1443"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004112">
        <property type="term" value="F:cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01261">
        <property type="entry name" value="CCA_bact_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01262">
        <property type="entry name" value="CCA_bact_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012006">
        <property type="entry name" value="CCA_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000813">
        <property type="entry name" value="CCA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0692">RNA repair</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000138973" description="Multifunctional CCA protein">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="232"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="413" mass="45087" checksum="B282BCB9719DB50D" modified="2004-10-25" version="1">MKIYAVGGAIRDALLGLPVRDRDYVVVGATPEQMAAQRFRPVGKDFPVFLHPDTHEEYALARTERKTAAGYHGFQFYYAPDVTLEQDLVRRDLTINAMAREVSPDGALVGPVVDPFGGQADLRAKLFRHVGDAFVEDPVRILRVARFAARFAEFAVAPDTAALMRAMVDAGEVDALVPERVWQELARGLMEAKPSRMFAVLRECGALARILPEIDALFGVPQRADYHPEVDTGVHVMMVIDHAAKQGYSLAVRFAALTHDLGKATTPADVLPRHIGHEGRSVDLLKPLCERLRVPNECRDLALVVAREHGNLHRVMEMGAAALVRLLERADALRKPARFAEALQASEADARGRLGLETKPYPQAERLRQALVAARAVDAGAIAQGLAGEPAKIKDAVHRARVRAVAQAVGVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YX4</accession>
    <name>Q63YX4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204738.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106691.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34049">
        <property type="protein sequence ID" value="CAH34049"/>
        <property type="gene ID" value="BPSL0066"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0066"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.74"/>
    <dbReference type="eggNOG" id="ENOG50344T9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYYDPWY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267713" evidence="2">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="16583" checksum="F14585381C772D77" modified="2004-10-25" version="1">MNRLILRCTTALIGSGAFVCACAQTYDGTTAPIDTSDCRAITGQADIDGTMQQVVGRACLQSDGTWRLVQNPDGSVPWYPLAAYPYPDPWYWGAPFFVGAGTTFVFVDHFHHFHRFHRFHPMTPGHVGPPAGGGVHHGPSRSGGMGGWGGTARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z01</accession>
    <name>Q63Z01_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor protein QseC</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL0039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524554.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106664.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0039"/>
    <dbReference type="EnsemblBacteria" id="CAH34022">
        <property type="protein sequence ID" value="CAH34022"/>
        <property type="gene ID" value="BPSL0039"/>
    </dbReference>
    <dbReference type="GeneID" id="56527683"/>
    <dbReference type="KEGG" id="bps:BPSL0039"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1707"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRMHRTL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013727">
        <property type="entry name" value="2CSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08521">
        <property type="entry name" value="2CSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="245"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="459" mass="49369" checksum="57BF2499BFA59E28" modified="2004-10-25" version="1">MSHSLRGRLLWWLLLPLAVFVAIAGAMSYDTARKTADLVQDGALVASARVIAEDVDWEGGALVANVPPAALELFASPAQDHVYYKVRTGGGRLLAGNPDLDGPAAPAASGAQPVLFDTALGGLAIRAVAYTRELYNAGNTETVTVVVGKTQTSRQMMIAAIWHPQLWRLALMLALAMALVYLGLTFELRPLMKLKEDVADRGPMELEPIRTERLHFELRPIVDAINQCIARLNLHAATQRRFIADAAHQLRTPIAVIDTQIQCARQRENGDAALAALLASMQRSSRRMADVTDKLLLLAHAEAASPARLAARVDIAAVVSGVLEEAIVLAERRRIDLGAELDDDLQVAGSESLLSALLMNLVDNAVRYAHEGGRVTVSARRDGDAVVLEVVDDGPGIPAEARPHVFKRFYRVARDEEGTGLGLAIVEEIAQSHGGAVSLATGPGNRGVRMTVRLPAYRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FD28</accession>
    <accession>Q63QL9</accession>
    <name>RL27_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name type="ordered locus">BPSL3004</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <title>Random sequencing of Burkholderia pseudomallei strain G9313 for clinical PCR development.</title>
            <authorList>
                <person name="Steiner B."/>
                <person name="Meyer R."/>
                <person name="Bowen M."/>
                <person name="Morrill W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>G9313</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF292383">
        <property type="protein sequence ID" value="AAG01348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194025.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109599.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FD28"/>
    <dbReference type="SMR" id="Q9FD28"/>
    <dbReference type="STRING" id="272560.BPSL3004"/>
    <dbReference type="EnsemblBacteria" id="CAH37015">
        <property type="protein sequence ID" value="CAH37015"/>
        <property type="gene ID" value="BPSL3004"/>
    </dbReference>
    <dbReference type="GeneID" id="60548291"/>
    <dbReference type="GeneID" id="66548402"/>
    <dbReference type="KEGG" id="bps:BPSL3004"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2265"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000181063" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAG01348." evidence="3" ref="1">
        <original>F</original>
        <variation>V</variation>
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="87" mass="9049" checksum="A3D214B2EA957F28" modified="2004-11-23" version="2">MAHKKAGGSSRNGRDSESKRLGVKVYGGQAINAGGIIVRQRGTRMHAGENVGMGKDHTLFALVDGHVKFTTKGAAKKHTVVVVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>H7C768</accession>
    <name>H7C768_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General secretion pathway protein H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gspH</name>
        <name evidence="14" type="ordered locus">BPSL0012</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GSP H family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106637.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0012"/>
    <dbReference type="EnsemblBacteria" id="CAH33995">
        <property type="protein sequence ID" value="CAH33995"/>
        <property type="gene ID" value="BPSL0012"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0012"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.12"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPRTDLN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022346">
        <property type="entry name" value="T2SS_GspH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002416">
        <property type="entry name" value="T2SS_protein-GspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12019">
        <property type="entry name" value="GspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01708">
        <property type="entry name" value="typeII_sec_gspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="GspH" evidence="13">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="17351" checksum="E00CAD4CA2B20A4E" modified="2012-04-18" version="1">MRPAGTASARRARGFTLLEMLVVLVIAGILVSVASLTLRRNPRTDLREEAQRIALLFETAGDEAQVRARPIAWRATEHGFRFDIRTGDGWRPLRDDVLRARDWDGGVTGAAIDYPGSDTHTDAVVFGTESIDVPVRVTLYSAVGSATIVGTGNGRYEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HS9</accession>
    <name>Q63HS9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estC</name>
        <name evidence="2" type="ordered locus">BPSS2341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523228.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112343.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2341"/>
    <dbReference type="ESTHER" id="burma-q629m1">
        <property type="family name" value="HNLyase_Bact"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39827">
        <property type="protein sequence ID" value="CAH39827"/>
        <property type="gene ID" value="BPSS2341"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2341"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5980"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPTHVHQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="PTHR10992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="301" mass="31892" checksum="FFE2CCAAC20BC909" modified="2004-10-25" version="1">MPTEPRDTVAERREPAASSSLPFVLVHGAWHGAWAYERVIPALAAHGHAAVARDLPAHGVNARFPASFAKRPLDAAAFASEPSPVAGTTLDDYVDHVLRTVDQARALGHERVVLVGHSMGGLAITMAAERAPEKIAKLVYLAAFMPTAGTKGLDYVRAPENQGEMLGPLMMASPKATGALRMDPRSDDPAYRAAAKRALCDDASDADHAAVGHLLGCDVPAAPFAARIETTAARWGALERHYIKCLRDKVLLPALQQRFIDEADALAPGNRTHVHTLDSSHSPFIAHAGAVADTLAAIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HT9</accession>
    <name>Q63HT9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MlaA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112333.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2331"/>
    <dbReference type="EnsemblBacteria" id="CAH39817">
        <property type="protein sequence ID" value="CAH39817"/>
        <property type="gene ID" value="BPSS2331"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2331"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6790"/>
    <dbReference type="eggNOG" id="COG2853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GCTTVQT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007428">
        <property type="entry name" value="MlaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30035">
        <property type="entry name" value="PTHR30035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04333">
        <property type="entry name" value="MlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01805">
        <property type="entry name" value="VACJLIPOPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266276" evidence="4">
        <location>
            <begin position="24"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="327" mass="33688" checksum="AC5D2C7CC4A44A25" modified="2004-10-25" version="1">MNKMRTTASALAVCLLASGCATGPNRHPGDPLEPMNRAVFQFNDAVDSAIAVPIAKGYQKVTPTPLRTAISNFFSNLGDLGNIANNLLQLRITDATQDVMRVAMNSVFGVAGLIDVASLAGLPKHHQDFGLTLARWGVPAGPYLVLPVFGPSSIRDGVGRAVDVRFNLLNYIEPAARNPMYIAQFISARSDLLGATDLLQQAALDKYSFVRDAYVQQRRSLTYHGRSDDESLPHYDEPGGEPAGGPGGGAPGGLPQYEDPGEGAGGMPPGGAREPAGLPQYQDPGDEAAASAAASAASSASSASSASPASSVAPASASSAQSPSSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV6</accession>
    <name>Q63HV6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sensor kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523251.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112316.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2314"/>
    <dbReference type="EnsemblBacteria" id="CAH39800">
        <property type="protein sequence ID" value="CAH39800"/>
        <property type="gene ID" value="BPSS2314"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2314"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5947"/>
    <dbReference type="eggNOG" id="COG4564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RNLMHPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017171">
        <property type="entry name" value="Sig_transdc_His_kinase_MctS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17200">
        <property type="entry name" value="sCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037314">
        <property type="entry name" value="STHK_MctS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="256"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="466" mass="50601" checksum="30488929D4943DD7" modified="2004-10-25" version="1">MRLKFKIFLLAIVPFLVTIAAIGLGVRQQATVLARTQHATIEAAYLSSKEIELKHYVDLATSAVAPLYEAGRANARDDALLRLQALAMLQRMEFGPDGYFFVYDLHGNALMHPREPERVGHNYWTLRDPRGSPTIQQLIAAASRGGGYVRYVWQRPSTGKLAPKLGYVVSLPRWGWMIGTGIYLDDVDNALARIDARASANIERTMTWLSAIALAGAAVIALCALVLNVSESRSADAKLKRLAQQVVESQEQERARLARELHDGISQMMVSAKLMFESALERLAHLPARENAAQAALSKGIARLGDTLREVRRISHALRPTMLDDLGLAAALDQLVRELGAETGVELGFTQVDHSGAPPLPAPVKTALFRIAQEALTNILRHAHATRAAVTLELSPREVALTIADNGRGFDAGRAQADARGGIGLRNMRERLDALGGTLEISSQIGHTVVAARVPLRGTDSPGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HW6</accession>
    <name>Q63HW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009982187.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112306.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39789">
        <property type="protein sequence ID" value="CAH39789"/>
        <property type="gene ID" value="BPSS2303"/>
    </dbReference>
    <dbReference type="GeneID" id="56531606"/>
    <dbReference type="KEGG" id="bps:BPSS2303"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5927"/>
    <dbReference type="eggNOG" id="COG1306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RPWIQDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025275">
        <property type="entry name" value="DUF4015"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13200">
        <property type="entry name" value="DUF4015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266442" evidence="1">
        <location>
            <begin position="30"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4015" evidence="2">
        <location>
            <begin position="145"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="463" mass="49701" checksum="B8BE5BBB6793E096" modified="2004-10-25" version="1">MTNPFAQWSRASACALAIVCFAPSGAAFAAQATADVPTAGASIASAASTPAPGTPTSAAAAARSFVTSPAAIHGAVVDARTGKPIPAAIVTIGGRPLRADDRGAFSADAAAADIAVRAPGYLATRARAEAGRPVTVALAPFRPKAVYLSVFGITSKTLREAAVDLKGATAINALVVDMKGDRGITPYPSAARRASGAAARTPNAPVVRDFAALVADLHRRGLYLIARIVVFKDDPLAAAHPEWTVRDADGNIWRDREKLRWIDPSLRETWAHNLDVAEEAAKLGFDEIQFDYVRFPDARELRFSVPNTRANRTAAIAGFLRAARERLAPYNVFVAADIFGYVCWNEDDTAIGQQIETLGGPLDYISPMLYPSGFTWGLPGCTQPTADPGQIVRRSLVEARSRTGLPGVRFRPWLQAFRDYAFDRRDFAAAEIRAQVDAAEAADTDGWMLWNARNRYDPRQLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I28</accession>
    <name>Q63I28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112244.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2241"/>
    <dbReference type="EnsemblBacteria" id="CAH39727">
        <property type="protein sequence ID" value="CAH39727"/>
        <property type="gene ID" value="BPSS2241"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2241"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5842"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="69" mass="7428" checksum="798709ED8EC77C46" modified="2004-10-25" version="1">MRPARPRDDNALYEPTRPLHEREGMDGVVLRSCAYNAVMQRPRVAGALALTAAALVVAALARARRGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I29</accession>
    <name>Q63I29_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112243.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2240"/>
    <dbReference type="EnsemblBacteria" id="CAH39726">
        <property type="protein sequence ID" value="CAH39726"/>
        <property type="gene ID" value="BPSS2240"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2240"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6672"/>
    <dbReference type="eggNOG" id="ENOG5033FKY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGHELSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="103" mass="11357" checksum="053A3055B0CBA7BB" modified="2004-10-25" version="1">MSMTSQHHPHTGHELSRARAHEGDRVQQDHDKGGHQGGHGKAPSPVDIQKALKGMDYPASKDEVVQCAERSHADGVVLDMLRRIPERQYETPASVSKEVGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I44</accession>
    <name>Q63I44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529441.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112228.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39711">
        <property type="protein sequence ID" value="CAH39711"/>
        <property type="gene ID" value="BPSS2226"/>
    </dbReference>
    <dbReference type="GeneID" id="56531684"/>
    <dbReference type="KEGG" id="bps:BPSS2226"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5818"/>
    <dbReference type="eggNOG" id="ENOG50316IR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QANICGG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="99" mass="11411" checksum="12A85D6808C0795A" modified="2004-10-25" version="1">METPKSTVHYESNVCGGSFESVLDRFGNWKREPLVYRPERRMFEGKDSVRRLGDEAFDSPDKARRALIRSCAPRDRFALAAPICDDDHQMWLVMAAFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I76</accession>
    <name>Q63I76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552238.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112196.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2194"/>
    <dbReference type="EnsemblBacteria" id="CAH39679">
        <property type="protein sequence ID" value="CAH39679"/>
        <property type="gene ID" value="BPSS2194"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2194"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5777"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIGICEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="16059" checksum="DC9845D700A502D4" modified="2004-10-25" version="1">MNTRPFALAGRRAQRGMAAVEFALVAAILCTILIGICEFGRVLFYWNTASEAVRLGARTAAVCDADASVVKTRIGQLMPLIGSANVRLAYTPAGCDSDAATARSTCTFVTVSVTNVTVKTLIPFVPLTLAMPPFVTTLPRESLATSTGGTVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG7</accession>
    <name>Q63IG7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112105.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2106"/>
    <dbReference type="EnsemblBacteria" id="CAH39586">
        <property type="protein sequence ID" value="CAH39586"/>
        <property type="gene ID" value="BPSS2106"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2106"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6495"/>
    <dbReference type="eggNOG" id="COG3522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTYFELD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="462" mass="51254" checksum="1718CF697F515EF5" modified="2004-10-25" version="1">MSATPAAALRQRVIWTEGMFLRPQHFQQLERHWERYVGMRCLPLQGFYWGYDELQIDRELLALGKVALLAATGVMRDGTPFDLSHPDDRPEPLDVPADAKDQLVVLALPLWRGGAQEVSFGAGGNGEGRGGDGNAHAGFARYVVREYEVADANEVALGPALLQTGRLNVRLMLESELTGDWQALGVARVVERRTDGRLLVDDGYIPPRLVAQRDPVLLRHTRELHGLLTQRSEALGERLSEPGRGGVSEVADFLLLQLVNRYLALTWHAQQDVAAHPETLFCDWLKLACDLSTFTAAGRRPQSLAVYRHDDLRASFGELMAELRRSLSTVLEQNAIQIELRDVGNGMKVATIADPALRDTAGFVLAVRADVPADSLRARFPAQAKLGPVERIRDLVQLQLPGIAMRQLPVAPRQIPYHAGHTYFEIDKGGEMWKQLERSGGLAFHFAGEFPGLSMEFWAIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IR5</accession>
    <name>Q63IR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112007.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39479">
        <property type="protein sequence ID" value="CAH39479"/>
        <property type="gene ID" value="BPSS2001"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2001"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6384"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="82" mass="8822" checksum="9E21E1C2546C9200" modified="2004-10-25" version="1">METNMKPTEFKITVSGAALDGRQIAHASAQLNIALLTALVGENATQIKGPAWNVVLPNGGRIIVAEEAERLLRVTEQERIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW5</accession>
    <name>Q63IW5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP synthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111957.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1951"/>
    <dbReference type="EnsemblBacteria" id="CAH39429">
        <property type="protein sequence ID" value="CAH39429"/>
        <property type="gene ID" value="BPSS1951"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1951"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6312"/>
    <dbReference type="eggNOG" id="ENOG5032RTR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLALRWM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="16745" checksum="46897E8D10C57145" modified="2004-10-25" version="1">MKREAREARDDAARGDARHAGAGAAPDDPRGAARRDPPPGSRAARGGATHPAARAAEPAAPKPAADRVERAAHTAAARAARGARDPEPSLGRRLAQIGVLGWTIVAPTLAALALGRWLDRMFATRVFFSAPLLMLGAALGLWLAWRWMKAQQHGDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX7</accession>
    <name>Q63IX7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552097.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111945.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1939"/>
    <dbReference type="EnsemblBacteria" id="CAH39417">
        <property type="protein sequence ID" value="CAH39417"/>
        <property type="gene ID" value="BPSS1939"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1939"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5426"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANIYRLG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="374" mass="40997" checksum="65EFD79633B5277D" modified="2004-10-25" version="1">MRRLAIVYRLGVKELWSLVRDPILLVLIAYTFTASIYSAATARPDTLHMAPIAIIDEDASPLSARIASAFFPPQFALPRMVTLAEADRGMNAGDFTFVLDIPPNFQRDVLAGRPAQIQLNVDATRMSQAFTGNGYVQQIVSGEIDDFARRYRANTAPPVDIAMHMRFNPNLDQTWFGSLMEVINNVTLLSMVLTGAALIREREHGTIEHLLVMPVTPGEIMLAKVWSMGLVVACAAAFSLAFVVRGALHVPIEGSVALFVIGMAIHLFATTSMGIFLATLVRSMPQFGMLLVLVLLPLQLLSGSLTPRESMPFAVQNIMLAAPTTHFVEIGQAILYRGAGIETVWRKFLILAVIGTALFLLSLKRFRKTIGQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IY6</accession>
    <name>Q63IY6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transport system, exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187814.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111936.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1930"/>
    <dbReference type="EnsemblBacteria" id="CAH39408">
        <property type="protein sequence ID" value="CAH39408"/>
        <property type="gene ID" value="BPSS1930"/>
    </dbReference>
    <dbReference type="GeneID" id="56529651"/>
    <dbReference type="KEGG" id="bps:BPSS1930"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5416"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVRVDID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="2">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="361" mass="38879" checksum="1F65D19D3A6AD879" modified="2004-10-25" version="1">MRQRIVFVAAIVGFLASLAAAWVYSIQEPPQPPVFKPASNPYPRGVYATGIVESDQSSGANVNLYPEVTGTVTRIFVREGDAVKAGDALLAIDDAVQRATAAQLAAQADAAQALLDEIRAQPRRETLDVAAAQVEAAAASLKTAQDQYDKQQRAFAIDPRAVSRDALDNALNGVKLARANLGVLTRQYRLTRAGAWVYDVRNQEKQAVALRKAADAAAALLARYTLRAPADGVVLAMNAAVGSYLSPQGMYDTYTQGATPALVLGSPANHLQVRCYVDEILISRLPAGKMPSAHMSVRGTAMEADLAFVRVQPYVTPKIQLSDQRAERVDVRVLPVIFRVVPRKDLRLFPGQIVDVYIASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ4</accession>
    <name>Q63JQ4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">SelB translation factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">selB</name>
        <name evidence="7" type="ordered locus">BPSS1662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551970.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111668.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1662"/>
    <dbReference type="EnsemblBacteria" id="CAH39136">
        <property type="protein sequence ID" value="CAH39136"/>
        <property type="gene ID" value="BPSS1662"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1662"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5061"/>
    <dbReference type="eggNOG" id="COG3276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAIDRVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015190">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09106">
        <property type="entry name" value="SelB-wing_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="641" mass="69031" checksum="9A4A1F5E55B19D59" modified="2004-10-25" version="1">MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPGHEKLVHTMAAGACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALNAHLRDTALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNRATDVGHAGERCALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTITHWTPLHVHLGTLHRVAHVALLEGETLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLMHLTGLPAQAWALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIAAPLADDALWRALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAATLMAEDAVRALLRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JU5</accession>
    <name>Q63JU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528900.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111627.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1619"/>
    <dbReference type="EnsemblBacteria" id="CAH39094">
        <property type="protein sequence ID" value="CAH39094"/>
        <property type="gene ID" value="BPSS1619"/>
    </dbReference>
    <dbReference type="GeneID" id="56529969"/>
    <dbReference type="KEGG" id="bps:BPSS1619"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5005"/>
    <dbReference type="OMA" id="ARDSEHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013390">
        <property type="entry name" value="T3SS_HpaP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09483">
        <property type="entry name" value="HpaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02557">
        <property type="entry name" value="HpaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="203" mass="21422" checksum="1689A7A23A3E6AB4" modified="2004-10-25" version="1">MSAADLRPVRIIAGAPAAEPAGAPAPRAARRGFDYAQLMRRSRVAPAGAPAPRGDGERPRDAAMPWRDGAAPSFERDPAALPDALGREAMARACAGADAFVNQVFAQRERVVRVAEALAAEIAALGGGDASGQWEISLPLDAALLPDTVLHLVLSRFDLRLRFETPDAATRHLLCTHGATLHARLDTLLAHHGAPRTIEIDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JX2</accession>
    <name>Q63JX2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 3 secretion system secretin</fullName>
            <shortName evidence="2">T3SS secretin</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sctC</name>
        <name evidence="5" type="ordered locus">BPSS1592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family. T3SS SctC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205648.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111600.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1592"/>
    <dbReference type="EnsemblBacteria" id="CAH39067">
        <property type="protein sequence ID" value="CAH39067"/>
        <property type="gene ID" value="BPSS1592"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1592"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4973"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLMARIS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02219">
        <property type="entry name" value="Type_III_secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003522">
        <property type="entry name" value="T3SS_OM_pore_YscC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01337">
        <property type="entry name" value="TYPE3OMGPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02516">
        <property type="entry name" value="type_III_yscC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026397510" description="Type 3 secretion system secretin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="4">
        <location>
            <begin position="175"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="601" mass="63364" checksum="0D3001BA001F0354" modified="2004-10-25" version="1" precursor="true">MKAKIPVLLSLLCSLASLSVDAAPIRWRSADIQYAAEGKDVKDVLRDFAASQNIAANVAPGVSGAVSGKMKMSPQRFLDTLAASFGFVWYYDGTVLYVTPASDMKSTLVKLDHANTGDLRDLLEQMKVSDSRYPITYNAQQRTALVAGPARYVELVTSVAARLDENSARTGGTQIRVFSLKHAWAADRDVNVDGTAVSMPGVASLLNRMYHPGEGKRASQTTLGKPISRAAPMTDLGGGRSGVPPPPLPPYMQAAQSGDGAAMPAGVPGVPGGDPRPSGMVAAAIANPGAARAPGGGMPDANGVPAGAGDAADLPVIQADPRTNSILVRDVPEHMAQYPDLIALLDVKPRLIEIEARIIEIDEGALKQLGVDWRAHNSHFDLQTGTGLTSQNGYANGTLNPTFGSITLSGNDSVGVPASPLGLSLTAVLGDAGRYLLARINALESSNQARTDASPKVTTLDNVEAVMDNKKQFFVRVAGYTSADLYSISTGVSLRVLPMVVDEGGRTQIKLDVRIVDGELSQQTVDNIPVIVSNEINTQAFIEQGQALLIAGYKVDARSSTQSGVPVLSKLPLVGALFRSTDKQNSHSERLFLVTPRVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K01</accession>
    <name>Q63K01_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528843.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111571.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1565"/>
    <dbReference type="EnsemblBacteria" id="CAH39038">
        <property type="protein sequence ID" value="CAH39038"/>
        <property type="gene ID" value="BPSS1565"/>
    </dbReference>
    <dbReference type="GeneID" id="56530025"/>
    <dbReference type="KEGG" id="bps:BPSS1565"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4930"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIEEWLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="134" mass="14920" checksum="E9ABE7A19C79D2C5" modified="2004-10-25" version="1">MTEAEPIRLEQFVARPPAQVWAALTTPAALARWWAAGDVRPVPGHRFTLDMGPWGRQPCEVIAVEPERRFAIAFAQRTLDTTITWRLEPAPGGTRVCFEHAGFDLDAPQARIAYDGMKRGWPSVLARIEQAIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K06</accession>
    <name>Q63K06_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative L(+)-mandelate dehydrogenase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mdlB</name>
        <name evidence="7" type="ordered locus">BPSS1560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551898.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111566.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1560"/>
    <dbReference type="EnsemblBacteria" id="CAH39033">
        <property type="protein sequence ID" value="CAH39033"/>
        <property type="gene ID" value="BPSS1560"/>
    </dbReference>
    <dbReference type="GeneID" id="56597906"/>
    <dbReference type="KEGG" id="bps:BPSS1560"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4924"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWSWEKI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="103"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="334"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="44053" checksum="E67142BC024F9017" modified="2004-10-25" version="1">MSTVTSSPIVEASRPAASAAATPRALRGVLSLHDFEARARRALPRPIFGYVGGAAEDNRTRDDNRAAFDEYGFVTRVLRDVSQRQQGVELFGRRYASPFGIAPMGINALSTYRGDIVLARAAQHAGIASIMSGSSLIPLEDVAAAAPDTWFQAYLPGDAGRIRALVERVARAGYRTLVVTVDIPVSANRENNVRSGFSTPLRPSPRLFWDGLTRPRWLLGTFARTLLAHGMPHFENSFATRGAPILSANVLRDFSARDHLSWAHVRQIREQWAGELVIKGVLSVEDARIAREAGADGIILSNHGGRQLDGAVSPMRILRDVVQAVGNGYPVMIDSGFRRGSDVLKAVALGARMVFVGRPFNYAAAVAGEAGVAHAIRLLREEVDRNLAMLGANGCDALTPDMLIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K12</accession>
    <name>Q63K12_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111560.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39027">
        <property type="protein sequence ID" value="CAH39027"/>
        <property type="gene ID" value="BPSS1554"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1554"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5815"/>
    <dbReference type="OMA" id="FEHEKVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="16129" checksum="A1076318CF95796A" modified="2004-10-25" version="1">MVALSGWTAWYVTVGAYRDLPGGKCVIRQPRFVLNKDGVTRQAMLSTSFWLDVHRVHVSGCFEHEKVNLSIDRSGSLQTLFRGDGSLLCRVNHVAYTARDSAAAHPLPSALPDVGDEIDLRFRKLASNAWIVETGDDRVGMCISEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K14</accession>
    <name>Q63K14_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SctL stator family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533272.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111558.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1552"/>
    <dbReference type="EnsemblBacteria" id="CAH39025">
        <property type="protein sequence ID" value="CAH39025"/>
        <property type="gene ID" value="BPSS1552"/>
    </dbReference>
    <dbReference type="GeneID" id="56530039"/>
    <dbReference type="KEGG" id="bps:BPSS1552"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4909"/>
    <dbReference type="eggNOG" id="ENOG5032SRA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYICEWK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012842">
        <property type="entry name" value="T3SS_SctL/SctL2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02499">
        <property type="entry name" value="HrpE_YscL_not"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="27754" checksum="7B71E725AA2C06DA" modified="2004-10-25" version="1">MRSSNLRQFPDTLAPLGGVLLKRAPLSQAARAERLLDEARRRAQRLVRDAEREADACRAHAATAGYEAGFARAIAELAAGVERIDAQRATLLERVVDDVRRSLEHLLDDPDLLLRIVNALASRRACATDRPLRVSVPPHAKRIAPAIRERLNDAYPSAQVVVADTRTFVVESGEDILEFDPRAVARALGDAALAACRAAAATAATAADGALARRAALDAPHPLAHGAAAIDDDRPRASLDTSTAQEPCDDPAANRDAHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K50</accession>
    <name>Q63K50_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111522.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1516"/>
    <dbReference type="EnsemblBacteria" id="CAH38989">
        <property type="protein sequence ID" value="CAH38989"/>
        <property type="gene ID" value="BPSS1516"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1516"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5771"/>
    <dbReference type="eggNOG" id="ENOG50342W5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GCEFFCG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="51538" checksum="352479233840C112" modified="2004-10-25" version="1">MSTDDLVKAPPEHRAKMAGVRLGIGSAGDRLNFLERNGVMPAEDKVLTAARYAHNVKIDHKNASNLEFQLNRMRIGEVSLPKQAKPDSMEIRNALDVIPLALPDRNEKHTIPTDKYLMNRLSSGAVEQARHHGCEFFCGSGRDEMLNHYAHRGFDRAISISSNTSTKFDLLSNSSNGKSLLVLSGMSSTTRIKHQLLQLHFADVDLNRVKLVGDINLLKAKSGDDLRKELSQLPPIPSKTLFIGARWQIMESLGKQLFHVGDSAKEGTGYGKLGVKEHKVADFVFDTATLNLDGRQHLVAALRMPNGDLAYDAMKGFLDHGFNQVIMCGAGGRLAGDAQVGDYMLLERSQYGDQSISLARECIHVPGAKLFENAKPTSNVTVDSPLQETQRWLDENQETGNVDVETAHILRALTEAGPDVKVLPGLFVSDVVGEHPLEGKISSDDAYRRLPEFVTASLGMIREQDTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA0</accession>
    <name>Q63KA0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551866.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111472.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1466"/>
    <dbReference type="EnsemblBacteria" id="CAH38937">
        <property type="protein sequence ID" value="CAH38937"/>
        <property type="gene ID" value="BPSS1466"/>
    </dbReference>
    <dbReference type="GeneID" id="56530120"/>
    <dbReference type="KEGG" id="bps:BPSS1466"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4800"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DAWKVYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="22"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="503" mass="53792" checksum="1CAD09A01F6424B2" modified="2004-10-25" version="1">MQFNDILAALDVDLSRWQGRALTARSPVDGATLATLAADAPADAERKIDAAHQAFLKWRTVPAPVRGELVRVFGNVLREHKAALGRLVTLEAGKIASEGLGEVQEMIDICDFAVGLSRQLYGLTIASERPGHRMMETWHPLGVCGVISAFNFPVAVWSWNAALAFVCGDPVVWKPSEKTPLTAIACHTLFAKAVREFDKTHPGVVPEGLHQLVLGGRDVGEALCASPKVPLVSATGSVRMGIEVAQVLSRRLARSILELGGNNGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSVADQLLPRLEKAFASVKVGDPLEAGTLVGPLIDRASFDAMQKALGDAREQGGEVKGGERVELGRADAYYVRPALVRMPRQTAVVTRETFAPILYVLVYDDFDEALAIHNGVPQGLSSAIFTNDMREAERFMSAAGSDCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKSYMRRATNTINYSRELPLAQGVKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA3</accession>
    <name>Q63KA3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202123.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111469.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1463"/>
    <dbReference type="EnsemblBacteria" id="CAH38934">
        <property type="protein sequence ID" value="CAH38934"/>
        <property type="gene ID" value="BPSS1463"/>
    </dbReference>
    <dbReference type="GeneID" id="56597714"/>
    <dbReference type="KEGG" id="bps:BPSS1463"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4797"/>
    <dbReference type="eggNOG" id="ENOG503096N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVEDQEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014469">
        <property type="entry name" value="DUF2271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10029">
        <property type="entry name" value="DUF2271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266939" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="16536" checksum="CA1C5F3E0FA9EE5F" modified="2004-10-25" version="1">MKHALPIAALAGALAAPSLAHARQVTFETQLADYGGDGAYVVLYVTDRAGRYQGTLWMAGRQTKYYRHLRDWYRATGGSARLDGITGASVGAGRTLRATLDVADALLDAGYEIHIDTAVEDMNENASEVVVPLNAAGAGKAVKGRGYVKSFRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS2</accession>
    <name>Q63KS2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553451.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111299.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38760">
        <property type="protein sequence ID" value="CAH38760"/>
        <property type="gene ID" value="BPSS1290"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1290"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4571"/>
    <dbReference type="OMA" id="WIVGVWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="18805" checksum="C81C01B5E1ABAAFC" modified="2004-10-25" version="1">MTDDITTPSPAPRPLPSFGPLRWIVRHWRGGYSLAVSFWLNQAPIYALRTICSQVLMTRVFELLDPGQGPGDNDALANALAAVPPVVLADAALSLLNVWWIVGVWRAASRHIAATGRRFWARAAQVMVALAAVRIVYGIAVIPHSIESLQLLVIHPGSLLTDPVGTLRNWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L58</accession>
    <name>Q63L58_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphocarrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528377.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111163.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1150"/>
    <dbReference type="EnsemblBacteria" id="CAH38618">
        <property type="protein sequence ID" value="CAH38618"/>
        <property type="gene ID" value="BPSS1150"/>
    </dbReference>
    <dbReference type="GeneID" id="56530436"/>
    <dbReference type="KEGG" id="bps:BPSS1150"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4375"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEIGPAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9027" checksum="F61296492E118151" modified="2004-10-25" version="1">MAQALIEIGPKWGRYDTARAGEALAGAAGRFQSDIVVVANGRHANAKDAMSVVALRAKCGTRMQILSSGPDEDDALDSLASLLTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L77</accession>
    <name>Q63L77_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552479.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111144.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1131"/>
    <dbReference type="EnsemblBacteria" id="CAH38599">
        <property type="protein sequence ID" value="CAH38599"/>
        <property type="gene ID" value="BPSS1131"/>
    </dbReference>
    <dbReference type="GeneID" id="56530455"/>
    <dbReference type="KEGG" id="bps:BPSS1131"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5285"/>
    <dbReference type="eggNOG" id="COG2771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GCWGCKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="267" mass="29734" checksum="0E7A379B546E9653" modified="2004-10-25" version="1">MPIGGQMSCFVDPLKLIFDHYPGLWGCQDSESRFIHVNDAFAKVVGVRDPRELEDKSAFDLPCGSSNCAAQFQAQDREVRETGRAIKVLDIHPYASGVWMAFVFTKIPLVDRNDEIVGTIFHATELSQIDMITLGRVIGDSYAGKRIGGPVEQGSYRIDSPRDALELTERERQVLFFLARNKTAKDIANILGLSARTIEQYMENLRCKFSASSKNELIDLAAGAGYCNRIPQSLLRNQLSVVLERGEPQMRDAREAARVPPAIIAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L99</accession>
    <name>Q63L99_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532962.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111122.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1109"/>
    <dbReference type="EnsemblBacteria" id="CAH38577">
        <property type="protein sequence ID" value="CAH38577"/>
        <property type="gene ID" value="BPSS1109"/>
    </dbReference>
    <dbReference type="GeneID" id="56530477"/>
    <dbReference type="KEGG" id="bps:BPSS1109"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4321"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQDAWCY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="29366" checksum="169060ED6CEE0373" modified="2004-10-25" version="1">MQTHTVGLSSEYEAQRYSNAHNILRSEIIYGDGFQSPGGIEGFKTMLAENMAIEPGMRLLDIGSGLGGAAFHLASRFDVTVVGLDTAPRMTELATARQPALDPHARVRFVNGDVHAEALAGERFDIIYSRDALMYVHDKPRLFARCHALLATRGRLYVTDFCRGRASPAFDAYASVSGYDLRTIDDYARIVADAGFDVLSARDVSDDARRQLRGDLDRYEARLAARDPSIDPLDAEHIVERWRRKIGFVDEGCLLQGLFVAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LP7</accession>
    <name>Q63LP7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mntH</name>
        <name evidence="5" type="ordered locus">BPSS0966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205492.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110974.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0966"/>
    <dbReference type="EnsemblBacteria" id="CAH38428">
        <property type="protein sequence ID" value="CAH38428"/>
        <property type="gene ID" value="BPSS0966"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0966"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5081"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SPKWLRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="431" mass="45157" checksum="19EB5991E2AB016D" modified="2004-10-25" version="1">MSRSAGDFATAGDASSRTVRAARDALEGRRKGVAAALPFVGPAVIASIGYMDPGNFATNIQAGAAYGYELLWVVLAANVIAMVFQAMSAKLGIVTGRNLAELCREHFPRPVVWGMWATSEIAAMATDLAEFLGGALAFGLLLHLPLIAGMAATAVLTCAILTLEKRGFRPLEAAIAALVGVIGASYLGELLIAPQDWHAAAYHLVVPQLRDGTALTLAVGIIGATIMPHTLYLHSGLTQRRTTPRDARERRLLLRFSNREVAVALGVAGFVNIAMVMMASSAFHRAAPGMADIGDAYHTLIPLLGPAAGALFLVALFASGVSSSVVGTLAGQVVMQGFLRRRVPIWMRRLVTIAPAFAIVALGCDVTRAMVLSQVVLSLVLPLPMAALLLLSSRRALLGEHALRAPTLVAASAAAAAIVALNVYLIWAAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LU5</accession>
    <name>Q63LU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551593.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110926.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38379">
        <property type="protein sequence ID" value="CAH38379"/>
        <property type="gene ID" value="BPSS0917"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0917"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7215"/>
    <dbReference type="eggNOG" id="COG3554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDGCIDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009467">
        <property type="entry name" value="Glycolipid-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06475">
        <property type="entry name" value="Glycolipid_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20506" checksum="E6F70F8571BC37B6" modified="2004-10-25" version="1">MREVCWASLEHDGIEHLAFERHARGSVAESVVVGWSGGRAYGLAYRVVCDARWRAKHVIVTVMGGGTLELRGDGEGRWRNAADERLGALDGCIDVDIAATPYTNTLPIRRLGLARGERRPVDVVYVSIPDLAVSAMQQAYQCIVPDRVYRYESVVSGFTAHLEVDRDGLVVDYEALFRRASDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA4</accession>
    <name>Q63MA4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184716.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110767.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0756"/>
    <dbReference type="EnsemblBacteria" id="CAH38216">
        <property type="protein sequence ID" value="CAH38216"/>
        <property type="gene ID" value="BPSS0756"/>
    </dbReference>
    <dbReference type="GeneID" id="56530794"/>
    <dbReference type="KEGG" id="bps:BPSS0756"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6995"/>
    <dbReference type="eggNOG" id="ENOG5032BHG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RCIDWRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025421">
        <property type="entry name" value="DUF4148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13663">
        <property type="entry name" value="DUF4148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266433" evidence="1">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="100" mass="10323" checksum="D32A108B63FFADE2" modified="2004-10-25" version="1">MKSIVVTAAAALVLAAPVVSFAQSPNGSLTRAQVIQELVDLESVGYQPSRGNDNTYPDDIQAAQRRLDAKRLATRKTAETAYGPAVAGTAQAGKPAAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MC8</accession>
    <name>Q63MC8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528002.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110743.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38191">
        <property type="protein sequence ID" value="CAH38191"/>
        <property type="gene ID" value="BPSS0732"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0732"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4792"/>
    <dbReference type="eggNOG" id="ENOG50342YU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IARWPNT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267370" evidence="1">
        <location>
            <begin position="34"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="232" mass="23661" checksum="B01AD5B675119E89" modified="2004-10-25" version="1">MTMKHLKINAALACIIDLACVHGGAAWAGSAGAATAEGDAKSWRSLLCAANGGRDITDQGALKIGGDVTAAVVCQYPDPAARASADTRAHAKANAGVVGGPILSTPVTANLRVPGGTFSLAAGNPLPLSCGVDLAIARWPNTPAVSQGTSTFNCRGYNVGSSSNGCSVQWSGPTPVTVGATPYGGGTTLHFTCVATHLGAFSTVTDYAYRDPLDPRIWYDVRDRFGTVNVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MD7</accession>
    <name>Q63MD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase / NADH oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527988.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110734.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38180">
        <property type="protein sequence ID" value="CAH38180"/>
        <property type="gene ID" value="BPSS0720"/>
    </dbReference>
    <dbReference type="GeneID" id="56530829"/>
    <dbReference type="KEGG" id="bps:BPSS0720"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6946"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASMQRPW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="39639" checksum="D854B2E4A5F89505" modified="2004-10-25" version="1">MAALFEPFQLKDVTLRNRIAVPPMCQYVAEDGVPNEWHHVHLAGIARGGAGLVIAEATAVSPEGRITPGCTGLWSDGQAAAFARSVAAIKAAGAVPGIQLAHAGRKASANRPWEGDDHIADGDPRGWRTIAPSAVPYGAHLPKVPREMTLDDIARVKADYVAAAKRALDAGFEWLELHFAHGYLAQSFFSVHSNRRADAYGGSAENRGRFLVETLAAVREVWPERLPLTARFGVIEYDGRDEQTLAESIELAKRFKLEGLDLLSVTIGFSTPAARIPWGPAFLAPVAERVRREAQLPVASAWGIDAPALAERVVSEGQLDLVMVGRAHLADPHWPYRAALELGVDRAPWTLPAPYAHWLERYRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MG2</accession>
    <name>Q63MG2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3,4-dihydroxyphenylacetate 2,3-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpcB</name>
        <name evidence="2" type="ordered locus">BPSS0695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.11.15" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194590.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110709.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0695"/>
    <dbReference type="EnsemblBacteria" id="CAH38155">
        <property type="protein sequence ID" value="CAH38155"/>
        <property type="gene ID" value="BPSS0695"/>
    </dbReference>
    <dbReference type="GeneID" id="56597621"/>
    <dbReference type="KEGG" id="bps:BPSS0695"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6909"/>
    <dbReference type="eggNOG" id="COG3384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVFDVHW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008687">
        <property type="term" value="F:3,4-dihydroxyphenylacetate 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07370">
        <property type="entry name" value="HPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011984">
        <property type="entry name" value="HPCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02298">
        <property type="entry name" value="HpaD_Fe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="31439" checksum="4FD99AAC087C3E29" modified="2004-10-25" version="1">MGKLSLAAKITHVPSMYLSELPGRHHGCRAEAIRGHQAIGERCRALGVDTIVVADTHWLVNAGYHVNCNGHFAGVYTSNELPHFIRDMRYEYPGNPALGHLIAASANERGIGTRAHEIDSLELEYGTLVPMRYMNADQRFKVVSIAGWCMWHALDESRRFGEALRHAIDASDANVAFLASGSLSHRFNDNGSPEEAIHMISREFYRQVDLRVVELWKQGDFATFCKMLPEYNAHCHGEGGMHDTAMLLGLLGWDRYDKPVEIVTDYFASSGTGQINAIFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MK7</accession>
    <name>Q63MK7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194594.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110664.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="DNASU" id="3095225"/>
    <dbReference type="EnsemblBacteria" id="CAH38102">
        <property type="protein sequence ID" value="CAH38102"/>
        <property type="gene ID" value="BPSS0645"/>
    </dbReference>
    <dbReference type="GeneID" id="56597667"/>
    <dbReference type="KEGG" id="bps:BPSS0645"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6840"/>
    <dbReference type="eggNOG" id="COG5475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEWFDEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019226">
        <property type="entry name" value="DUF2158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09926">
        <property type="entry name" value="DUF2158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="89" mass="10006" checksum="2BCF1680F49B1AF4" modified="2004-10-25" version="1">MTTYRDTHTTSFRIGDVVTLKTGGPRMTVTYAGPVVFDTGEWVICQWFDENGEFRQEMFPNETVVLEPRTISAGLARMRSLSVRGGMQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-06-13" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MT0</accession>
    <name>LCDH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-carnitine dehydrogenase</fullName>
            <shortName evidence="1">CDH</shortName>
            <shortName evidence="1">L-CDH</shortName>
            <ecNumber evidence="1">1.1.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lcdH</name>
        <name type="ordered locus">BPSS0568</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19265"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17126"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57885"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine metabolism; carnitine metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.108" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009923734.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110589.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63MT0"/>
    <dbReference type="SMR" id="Q63MT0"/>
    <dbReference type="STRING" id="272560.BPSS0568"/>
    <dbReference type="PRIDE" id="Q63MT0"/>
    <dbReference type="EnsemblBacteria" id="CAH38025">
        <property type="protein sequence ID" value="CAH38025"/>
        <property type="gene ID" value="BPSS0568"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0568"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6737"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KREIQGF"/>
    <dbReference type="UniPathway" id="UPA00117"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047728">
        <property type="term" value="F:carnitine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042413">
        <property type="term" value="P:carnitine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02129">
        <property type="entry name" value="L_carnitine_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026578">
        <property type="entry name" value="L-carnitine_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000417898" description="L-carnitine dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02129"/>
        </source>
    </evidence>
    <sequence length="321" mass="34839" checksum="C8B924499DA56E8D" modified="2004-10-25" version="1">MAVITKIDTFAAIGAGVIGSGWVARALANGLDVLAWDPAEGAEMQLRANVENAWPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHRPERCIVGHPFNPVYLLPLVEVLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDALIDRVVEGTAEQQGPRSIKALERYRDECITEVIAAIAAVKARHGMRYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N06</accession>
    <name>Q63N06_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4 11">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ahpC</name>
        <name evidence="13" type="ordered locus">BPSS0492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4 11"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525522.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110513.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63N06"/>
    <dbReference type="STRING" id="272560.BPSS0492"/>
    <dbReference type="EnsemblBacteria" id="CAH37949">
        <property type="protein sequence ID" value="CAH37949"/>
        <property type="gene ID" value="BPSS0492"/>
    </dbReference>
    <dbReference type="GeneID" id="56531059"/>
    <dbReference type="KEGG" id="bps:BPSS0492"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6645"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03137">
        <property type="entry name" value="AhpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH37949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="20619" checksum="9DB00ABEA2C1FFCB" modified="2004-10-25" version="1">MPIINSPIKPFKATAYHNGDFVQVSDETLKGKWSVVVFYPADFTFVCPTELGDLAERYAEFQKLGVEIYAVSTDTHFTHKAWHDTSDTIAKIKYPMIGDPTLAISRNFDVLIEEEGLALRGTFVINPQGEIKLCEIHDNGIGRDAGELLRKVQAAQYVAAHPGEVCPAKWTPGADTLTPSLDLIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N62</accession>
    <name>Q63N62_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939434.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110457.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0434"/>
    <dbReference type="EnsemblBacteria" id="CAH37890">
        <property type="protein sequence ID" value="CAH37890"/>
        <property type="gene ID" value="BPSS0434"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0434"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6573"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RCLPHAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="36789" checksum="293C846A2FD2147C" modified="2004-10-25" version="1">MNHLRNLLGHLKHTDDFAAYRLPHDLIERACRYGSLVRVERGATLCASGARSDALYVVLDGATRCLPHARLPLPCGIDHGPGTFTGELDLLNDVGCEVTVVASSACRLARIERATLRHLLRREPALRDVLVRVFLLRRIGALASGAADTPLRERGAEPAFDVAIVGSGAAGMIAAAHAASLRLNTVVAEGRLPFGIDDEFASAAPPARRQFGPFLTLRDHTVRLDCNAYPFRLVTRGGERLRAHAVVIASSLRPEYSPRRARVTLRANTEWLDGAVDVDDDGFVRTGRAASGTTLAAAFESSQPGVFAIGAVRAGPRRSALGELTEGAVVVDAIRRFIRASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NH5</accession>
    <name>Q63NH5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glcA</name>
        <name evidence="9" type="ordered locus">BPSS0324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529870.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110344.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0324"/>
    <dbReference type="EnsemblBacteria" id="CAH37772">
        <property type="protein sequence ID" value="CAH37772"/>
        <property type="gene ID" value="BPSS0324"/>
    </dbReference>
    <dbReference type="GeneID" id="56531215"/>
    <dbReference type="KEGG" id="bps:BPSS0324"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6440"/>
    <dbReference type="eggNOG" id="COG1620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIVLWIQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="572" mass="59704" checksum="7243E795CAFC3CD6" modified="2004-10-25" version="1">MQVWNQVYLPLGGVGWSALAAGAPIILFFVSLAVLRLKGHVAGALTLALALVIAIAVYGMPAERAFASAAYGFAYGLWPIAWIIVTAVFLYKIVVKSGQFDVIRSSIVALTDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIADTAPVAFGALGIPVIVAGQVSGLDPMAVGAMAGRQLPFLSFFLPFWLVFVMDGVKGVRETWPAALVAGGSFALVQFFTSNYIGPELPDVTSALASLVALASFLKVWRPLRAREAARAQRLVSAGGGALALGGMPGGLGGARATGGREPSPYSFAQIARAWSPFVVLTVMVTIWSMKPFKALFAKGGALAFTTLQFHVAHLDKLTQKMAPVVAHPTPVPAVFNWDLLAATGTAILLSAIVSMAILNVPARTGVRTFFEVLKDLKRPVLSIGLVLAFAFVENYSGMSTTLALLLAGTGAAFPFFSPLLGWIGVFLTGSDTSSNALFCSLQATTAQQIGVPSTLLVAANTTGGVAGKMISPQSIAVACAAVGLVGHEADLFRFTLRHSLFFALVVGVMTCVQAYWLTGMIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NJ3</accession>
    <name>Q63NJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative multifunctional polyketide-peptide syntase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205383.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110326.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0306"/>
    <dbReference type="EnsemblBacteria" id="CAH37754">
        <property type="protein sequence ID" value="CAH37754"/>
        <property type="gene ID" value="BPSS0306"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0306"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6412"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RERTGTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2042"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2797"/>
            <end position="2872"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3635"/>
            <end position="3710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1634"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2133"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2776"/>
            <end position="2800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2900"/>
            <end position="2929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3501"/>
            <end position="3525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2079"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2832"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="4133" mass="435906" checksum="8BA9F18D80F00D19" modified="2004-10-25" version="1">[encoded data, 4133 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P80</accession>
    <name>Q63P80_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110089.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37508">
        <property type="protein sequence ID" value="CAH37508"/>
        <property type="gene ID" value="BPSS0064"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0064"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3980"/>
    <dbReference type="eggNOG" id="ENOG5031D4D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RASNCTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="186" mass="20209" checksum="EEFFCF5D4A5AE38F" modified="2004-10-25" version="1">MSRVVFRVSCFVQGAENAERRHATPGRGACIPARDRPESHYNPTFVPMTAPRTMLLLRHSILAALAATACASAHAQTADDTPVAAPACAIAIVTGVGGAATNLREYLAARERDRYRYLADHPLDCRVSEDGRASGCTGLAYLRRERVSVYDDGDDTVQNVVARVDLDHGTYPAIIAVQKRDVRCEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PH6</accession>
    <name>ATPF_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit b</fullName>
            <shortName evidence="1">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpF</name>
        <name type="ordered locus">BPSL3400</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH37412" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37412.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185283.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109993.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PH6"/>
    <dbReference type="SMR" id="Q63PH6"/>
    <dbReference type="STRING" id="272560.BPSL3400"/>
    <dbReference type="EnsemblBacteria" id="CAH37412">
        <property type="protein sequence ID" value="CAH37412"/>
        <property type="gene ID" value="BPSL3400"/>
    </dbReference>
    <dbReference type="GeneID" id="56593900"/>
    <dbReference type="GeneID" id="66545408"/>
    <dbReference type="KEGG" id="bps:BPSL3400"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1790"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAWKPIL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000368391" description="ATP synthase subunit b">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="156" mass="17122" checksum="F9A37A74CBE73834" modified="2009-04-14" version="2">MNLNATLFAQMVVFLVLAWFTMKFVWPPLINALDERSKKIADGLAAAEKGKAELEAAHKRVDQELAQARNDGQQRIADAEKRALAVADEIKTNAQAEAARIIAQAKAEAEQQIVKARETLRGEVAALAVKGAEQILKREVDQTAHAELLNQLKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM2</accession>
    <name>Q63PM2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938965.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109947.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3351"/>
    <dbReference type="EnsemblBacteria" id="CAH37364">
        <property type="protein sequence ID" value="CAH37364"/>
        <property type="gene ID" value="BPSL3351"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3351"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1852"/>
    <dbReference type="OMA" id="VAMDVGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008020">
        <property type="entry name" value="G8P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05356">
        <property type="entry name" value="Phage_Coat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266514" evidence="2">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="68" mass="6727" checksum="8FA9D7C10F93EF9F" modified="2004-10-25" version="1">MKKLFVAALSLASAGAFAADAGTPTMDVTSVVASINGVGPNIVLVGGAVLAVAAVTFGYRTVRSFIGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q62</accession>
    <name>UGPC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">sn-glycerol-3-phosphate import ATP-binding protein UgpC</fullName>
            <ecNumber evidence="1">7.6.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ugpC</name>
        <name type="ordered locus">BPSL3163</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:21668"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.10" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004542709.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109756.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q62"/>
    <dbReference type="SMR" id="Q63Q62"/>
    <dbReference type="STRING" id="272560.BPSL3163"/>
    <dbReference type="EnsemblBacteria" id="CAH37173">
        <property type="protein sequence ID" value="CAH37173"/>
        <property type="gene ID" value="BPSL3163"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3163"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2076"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APPMNLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015430">
        <property type="term" value="F:ABC-type glycerol-3-phosphate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017922">
        <property type="entry name" value="UgpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43875:SF12">
        <property type="entry name" value="PTHR43875:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51315">
        <property type="entry name" value="UGPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000289742" description="sn-glycerol-3-phosphate import ATP-binding protein UgpC">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01727"/>
        </source>
    </evidence>
    <sequence length="360" mass="38692" checksum="39D0F311B8B8906E" modified="2004-10-25" version="1">MAALSLKGVRKSYGGAQYVLHGIDVDIADGEFVVLVGPSGCGKSTLLRMIAGLETVTEGEIAIGGRVVNALEPKDRDIAMVFQNYALYPHMTVAQNMGYGLKIRGVERALIDARVQAAAQILELGPLLARRPRELSGGQRQRVAMGRAIVREPSVFLFDEPLSNLDAKLRVQMRLEIQRLHARLATTSVYVTHDQIEAMTLAQRVIVMNRGYAEQIGAPVDVYEKPATTFVASFIGSPAMNLLHGRLSEDGAAFDVADGPRLPVAGAAGAGRGIAPGREWILGVRPEHMTPQPGEAFATLAVDSCELLGADNLAHGRWGAHDVAVRLPHAMRPTRGETLPVALPARHLHFFDPATGKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q64</accession>
    <name>Q63Q64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199949.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109754.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3161"/>
    <dbReference type="EnsemblBacteria" id="CAH37171">
        <property type="protein sequence ID" value="CAH37171"/>
        <property type="gene ID" value="BPSL3161"/>
    </dbReference>
    <dbReference type="GeneID" id="56594067"/>
    <dbReference type="KEGG" id="bps:BPSL3161"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2078"/>
    <dbReference type="eggNOG" id="COG3047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AKQWSPT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005618">
        <property type="entry name" value="OMPW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36920">
        <property type="entry name" value="PTHR36920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03922">
        <property type="entry name" value="OmpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267051" evidence="2">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="243" mass="25899" checksum="F0403119744DFBE9" modified="2004-10-25" version="1">MKQKMAITGAVALAFAAAATGAHAQSAGSFYVTTGWFHLAPQDSSDPLKIMNVGGSPVNHEVPNTGAGIDNADTIGLAAGYFLTDHIATELVAGIPPRFNLNGKGSLEQFGVLGHAYQWSPALLLKYYFNDAKAKFRPYVGIGASYIWFTGAKITNTAFERGALGGPTSVQTSNQWAPVLNAGFTYNFTDHWFGGLSVSYIPVSLTATLTTQRPTPIGNVTQTSQAKITLNPIVTYLNIGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q74</accession>
    <name>Q63Q74_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">thiE</name>
        <name evidence="10" type="ordered locus">BPSL3151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205266.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109744.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3151"/>
    <dbReference type="EnsemblBacteria" id="CAH37161">
        <property type="protein sequence ID" value="CAH37161"/>
        <property type="gene ID" value="BPSL3151"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3151"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2092"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDHWQIA"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="9">
        <location>
            <begin position="175"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="342"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="364" mass="38046" checksum="5D5059F3DAC03A2B" modified="2004-10-25" version="1">MSAALPDAFWPPADELTEAAERIRATLGAWQRPAVRTRICLAPPEQPRAADLWVAIAGAHAAHIARLNAAGAQAIVIDDASATLHTGAARHALASRAPLADDWIAALAAFLDCGFAASDALVLALAWRDGDEARGGDPWPVDPARFPRVLGLPAAPEPAFAPCPQRLGLYPVLPSAEWVERVLDCGVRTVQLRVKDASPDALRAEIERAVAAGRRHPDARVFINDHWRLALDAGAYGVHLGQEDLETADLGAIARAGARLGLSSHGYYEMLVALQFKPSYLALGPVFATATKAVAAPPQGLARLARYVRFAGPQAPLVAIGGIAPDTLGAVLAAGVGSAAVVSAITAAADYQEAIVALQQNFGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q92</accession>
    <name>HIS6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisF</fullName>
            <shortName evidence="1">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisF</name>
        <name type="ordered locus">BPSL3133</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH37143" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37143.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550994.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109726.2">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q92"/>
    <dbReference type="SMR" id="Q63Q92"/>
    <dbReference type="STRING" id="272560.BPSL3133"/>
    <dbReference type="EnsemblBacteria" id="CAH37143">
        <property type="protein sequence ID" value="CAH37143"/>
        <property type="gene ID" value="BPSL3133"/>
    </dbReference>
    <dbReference type="GeneID" id="56528025"/>
    <dbReference type="KEGG" id="bps:BPSL3133"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2110"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000142137" description="Imidazole glycerol phosphate synthase subunit HisF">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="257" mass="26979" checksum="C9796CA1877274A9" modified="2005-02-01" version="2">MALAKRIIPCLDVTAGRVVKGVNFVELRDAGDPVEIARRYDAQGADELTFLDITATSDGRDLILPIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVSMNSSAVANPPLVRDAADKYGSQCIVVAIDAKRVSADGEPPRWEVFTHGGRKGTGLDAVEWARKMAELGAGEILLTSMDRDGTKAGFDLALTRAVSDAVPVPVIASGGVGSLEHLAAGITEGHADAVLAASIFHYGEHTVGEAKRFMAERGIAVRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QF0</accession>
    <name>RF1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
            <shortName evidence="1">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfA</name>
        <name type="ordered locus">BPSL3073</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527811.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109668.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QF0"/>
    <dbReference type="SMR" id="Q63QF0"/>
    <dbReference type="STRING" id="272560.BPSL3073"/>
    <dbReference type="EnsemblBacteria" id="CAH37084">
        <property type="protein sequence ID" value="CAH37084"/>
        <property type="gene ID" value="BPSL3073"/>
    </dbReference>
    <dbReference type="GeneID" id="56528114"/>
    <dbReference type="KEGG" id="bps:BPSL3073"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2181"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177650" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <sequence length="360" mass="40484" checksum="7764F5ED4DA2AC54" modified="2004-10-25" version="1">MKTSMQSKLDQLTTRLAELNDLLSRENVTADLDQYRKLTREHAEIGPVVEHYAQWRQARADELAAQELLADASMRDFAEDELRGARDRMGRLAAELQTMLLPKDPNDERNIFVEIRAGTGGDESALFAGDLLRMYLRYAERQRWQVEMMSESPSDLGGYKEVIVRIAGYGAYSRLKFESGGHRVQRVPATETQGRIHTSACTVAVMPEADEIGEVEINPADLRIDTFRASGAGGQHINKTDSAVRVTHIPTGIVVECQDDRSQHKNKDRALKVLAARIKDKQYHEQHAKEAATRKSLIGSGDRSERIRTYNFPQGRMTDHRINLTLYKLEQIMDGDLDELIAALVSEHQAELLASLGDAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI9</accession>
    <name>RSMH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">BPSL3033</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938761.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109629.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QI9"/>
    <dbReference type="SMR" id="Q63QI9"/>
    <dbReference type="STRING" id="272560.BPSL3033"/>
    <dbReference type="EnsemblBacteria" id="CAH37045">
        <property type="protein sequence ID" value="CAH37045"/>
        <property type="gene ID" value="BPSL3033"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3033"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2233"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000108597" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="313" mass="34209" checksum="EC98929C8CB38C8C" modified="2004-10-25" version="1">MGNEFQHRTVLLDEAVDALVTRPDGVYVDGTFGRGGHSRAVLARLGYAGRLIAFDKDPRAIETAESIEDARFEIVHDSFAAMKGALDARGIGRVSGVLLDLGVSSPQVDDPARGFSFRANGPLDMRMDPTRGESAAEWLARASVQELTEVIRDYGEERFAFQIAKAIVARRAESDRLGPLDSTGELAQIVGHVVKTREKGKDPATRTFQAIRIHVNQELADLQVVLEAALSLLEQGGRLVVISFHSLEDRIVKRFLQAHASAPAVDRRLPIRAADLPRPPLKLLGRMFPNDAEVAANPRARSAVMRIAERVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QT2</accession>
    <name>Q63QT2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer membrane protein assembly factor BamE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">omlA</name>
        <name evidence="4" type="synonym">bamE</name>
        <name evidence="7" type="ordered locus">BPSL2942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BamE family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109536.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2942"/>
    <dbReference type="EnsemblBacteria" id="CAH36952">
        <property type="protein sequence ID" value="CAH36952"/>
        <property type="gene ID" value="BPSL2942"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2942"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3362"/>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDYVFYF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00925">
        <property type="entry name" value="OM_assembly_BamE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026592">
        <property type="entry name" value="BamE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037873">
        <property type="entry name" value="BamE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007450">
        <property type="entry name" value="Lipoprotein_SmpA/OmlA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37482">
        <property type="entry name" value="PTHR37482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04355">
        <property type="entry name" value="SmpA_OmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SmpA_OmlA" evidence="6">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="28378" checksum="45D6761DD9D033AD" modified="2004-10-25" version="1">MIPRSLLQLQRSRVRSTVIAAVAVVGLAACSSYDSVTQRIAQSITPYRITVVQGNFVSQEKASQLQVGMSREQVRALLGTPLLTDMFHADRWDYLFYFKRGSTSVVQQRDLVVNFAGDRLAGWSGAENLPSELDLLADIDGDRRGKKARAAAAARAASAPEAAAAAPEAMQAAEQNDANAQAARAANRATAQVPGQSGAASRFAPSAQMAPNAPTPGGLPPGAAPAIQPQFQFHRPPPPPAQGGANQPVGPQGADALPNQPLTAPASGAQGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU6</accession>
    <name>Q63QU6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">purB</name>
        <name evidence="14" type="ordered locus">BPSL2928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109522.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2928"/>
    <dbReference type="EnsemblBacteria" id="CAH36938">
        <property type="protein sequence ID" value="CAH36938"/>
        <property type="gene ID" value="BPSL2928"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2928"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3345"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TQVNPCD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="12">
        <location>
            <begin position="41"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="13">
        <location>
            <begin position="358"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH36938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="483" mass="54193" checksum="A764A34CFF5143BA" modified="2004-10-25" version="1">MVKFAVLPFTFEPRPRASSPIMSDTRPDTLFALTALSPLDGRYASKTEALRDWLSEAAFMRHRVTVEVHWLIALSRAGFAEVPRFSEAAEQFLLQLVERFTAHDAARIKEIERVTNHDVKAVEYWLKESVKGQVELEQASEFIHFACTSEDINNTSHGMMLAGARQHVILPALRTVHGRLVALAHAHAEQPMLSRTHGQPASPTTLGKEIANVAARLARAIERIEKVEILGKMNGAVGNFNAHLSAYPEFDWEAFSRDVIEHRLKLTFNPYTIQIEPHDYMAELFDAVSRANTILLDLDRDVWGYISLGYFKQKTKAGEIGSSTMPHKVNPIDFENSEGNLGLANATLRHLADKLPVSRWQRDLTDSTVLRNIGVAFGYSLLAYDALIRGLDKLEVNPQRLNDDLDNCWEVLAEPVQTVMRRYGIENPYEQLKELTRGKGITRDALQQFIGTLAIAEDAKARLLAMTPASYIGKAVELAKRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R27</accession>
    <name>Q63R27_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ordered locus">BPSL2847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522133.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109441.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2847"/>
    <dbReference type="EnsemblBacteria" id="CAH36857">
        <property type="protein sequence ID" value="CAH36857"/>
        <property type="gene ID" value="BPSL2847"/>
    </dbReference>
    <dbReference type="GeneID" id="56528351"/>
    <dbReference type="KEGG" id="bps:BPSL2847"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2454"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="270" mass="27473" checksum="727C2876A7759D21" modified="2004-10-25" version="1">MKIAFIGGGNMAAALIGGLVKRGVDASGLLAVDVNEDARQRAQAQFGVRTAAAVDATLAGYDAIVLAVKPQVLKDVALALAPHLTTQLVVSIAAGIRGADLSRWLGDYPRVVRTMPNTPALVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDESQLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPAGVLRERVTSKGGTTAAALASFDAQHVKDAIVRGVLAAQARAREMGDELGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RG7</accession>
    <name>Q63RG7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527609.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109301.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2705"/>
    <dbReference type="EnsemblBacteria" id="CAH36713">
        <property type="protein sequence ID" value="CAH36713"/>
        <property type="gene ID" value="BPSL2705"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2705"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2629"/>
    <dbReference type="eggNOG" id="ENOG5033PIE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMTFQIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021340">
        <property type="entry name" value="DUF2957"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11170">
        <property type="entry name" value="DUF2957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267084" evidence="1">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="417" mass="43649" checksum="3B597425FCB75758" modified="2004-10-25" version="1">MYWRKSLAAALLAPVLTACGGGDDPPPAPVVRLCPKTIDYNTVFTGGSGSGELVRVQLDTTKMTFQITYLASPVPATTGTVQPTRDAAPNNIVTGTLTDETGLPTEKLNQCTFRLNNASLDPNRPARVFLGEGVLGGAIPGATIQFGGVIGVGQIPKTTFPYYPFISFSDQETDLSKIAGNYNQLGYHQVPSQNFAQAAVDAKVTINADGTYVETDNFGRKNGGQPLASSATVNQKLTLRADAPVFQSLNYQPQVPPTLASLDPSKAGKGILIVGKLRNQLVPIFIRTGAANADLTQGAPVADDESGISILSPQTAIASGSQDGEYTGVDSVLDYRATALVGAQATLLDPFHASQVALTRSLNLDYTQTVPGVVTTVQTNAASGPPTGKFVFTGGVFGLLDMSDVNNPYFTVGAFVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RS6</accession>
    <name>MINE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">minE</name>
        <name type="ordered locus">BPSL2595</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186076.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109191.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RS6"/>
    <dbReference type="SMR" id="Q63RS6"/>
    <dbReference type="STRING" id="272560.BPSL2595"/>
    <dbReference type="EnsemblBacteria" id="CAH36603">
        <property type="protein sequence ID" value="CAH36603"/>
        <property type="gene ID" value="BPSL2595"/>
    </dbReference>
    <dbReference type="GeneID" id="60548700"/>
    <dbReference type="GeneID" id="66547992"/>
    <dbReference type="KEGG" id="bps:BPSL2595"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2762"/>
    <dbReference type="eggNOG" id="COG0851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QIIVARE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000298090" description="Cell division topological specificity factor">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <sequence length="84" mass="9395" checksum="8F6BBC592ED00E24" modified="2004-10-25" version="1">MSILSFLLGEKKKSAAVAKERLQLIIAHERVGGRPPADYLPALQKELVAVISKYVKISNDDIRVSLERQDDLEVLEVKIEIPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU0</accession>
    <name>Q63RU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552541.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109177.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2580"/>
    <dbReference type="EnsemblBacteria" id="CAH36588">
        <property type="protein sequence ID" value="CAH36588"/>
        <property type="gene ID" value="BPSL2580"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2580"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2783"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="91" mass="10170" checksum="2C1DA6FFFC54A547" modified="2004-10-25" version="1">MRDLYMRISAFPLTQTERIAVSVGAFADRTYVYLQLSRVTVDETALRPLGRRVHIPAECLDRLIAALCEARDKLASDPDTWSAERADGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RY3</accession>
    <name>Q63RY3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189595.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109134.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2538"/>
    <dbReference type="EnsemblBacteria" id="CAH36545">
        <property type="protein sequence ID" value="CAH36545"/>
        <property type="gene ID" value="BPSL2538"/>
    </dbReference>
    <dbReference type="GeneID" id="56596418"/>
    <dbReference type="KEGG" id="bps:BPSL2538"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2837"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YCIVMTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014308">
        <property type="entry name" value="Xanthine_DH_XdhC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02964">
        <property type="entry name" value="xanthine_xdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="36072" checksum="EE6BAC5591DCCCC4" modified="2004-10-25" version="1">MQTWLTDLQHLLARGDAAVLVTVARVDGSAPRDAGTKMLVTRDAARHTIGGGHLEWKAIDIARQLLKEGAHTPHARRLERLALGPSLGQCCGGAVVLAFERLDIAELGWVTSLAKRVAAGAPTVRSVSFGPDADTVMLSEPEPGATRPDCLLWDMGGAPLLTETIAPHAFPVVLFGAGHVGAALVRVLGTLPCHVRWVDERDAQFPPPDALAGIRNLSLDANDAPDEAIDEAGPGAYFVVMTHNHARDLELAHRILARGDYAYFGMIGSRTKRMQFEHRLAARGIDPLQIARMQCPIGVPGIVDKAPEAIAIAVAAQILQTVDARRANGRPAASPGASAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S16</accession>
    <name>Q63S16_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exported transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="Lysozyme-like_dom_sf"/>
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        <property type="entry name" value="Lytic_transglycosylase_MltB"/>
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        <property type="entry name" value="MltB-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163:SF0">
        <property type="entry name" value="PTHR30163:SF0"/>
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        <property type="entry name" value="MltB"/>
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    <proteinExistence type="predicted"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
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    </evidence>
    <sequence length="450" mass="48914" checksum="15BE47A4FD6CB94A" modified="2004-10-25" version="1">MSVILPRNRPSRPLRFDMIFHQPAAPASLAFRLRFPLAALSLAATLFASAAVAQTQPAAAVVAQEPAQPQSQSQSQSQLQPQPQPQPQPQPSVQQGQTFEEEIIPQRYANNAKIDAFIADMVARHDFDANALHALFARVSYSATAAKLVMPAPSPAVKNWRVYQSRFLDAVRVNAGVKFWRANQGTLQRASTEFGVPPEVIVGIIGVETIYGRYMGNFRTLDALTTLAFDYPNTPNRDARQATFRKNLEDFLVWTRDSQLDPTGVLGSYTGAVGIPQFLPSSIRDYAVDYDGNGHIDLRASQADAIGSVANYLKQHGWETGRPVVWNIAPDTGSQGVAQAAADGRPEPHWVLSQLLRAGLVLDEPSVNIASEASTPVTVVDLPTPGRATEYKLGLQNFYVLTRYNRSFFYALAVYQLGERVKAQMEASGALTPSPADAATGSPAAQPPSE</sequence>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
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                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
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                <person name="Hance Z."/>
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                <person name="Keith K.E."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
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    <dbReference type="PATRIC" id="fig|272560.51.peg.2907"/>
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        </source>
    </evidence>
    <sequence length="487" mass="56042" checksum="6A33FF16D2C3DBE5" modified="2004-10-25" version="1">MLKTPMPTQHELEMVTLEELVPKDHLLRQIDAAVDFEFIRAKVAHLYCADNGRPALDPVVMFKLLFIGYLFGVRSERQLMREVQVNVAYRWFARFRLTDKVPDASTFSQNRRRRFTDTTVYQEIFDEIVRQAIKRGLVDGRVLYTDSTHLKANANKGKFDVVKLEQTPAAYTEALNAAVDADRAAHGRKPLDRDDDEPPSSKDTKISRTDPDSGYMVRDDKPKGFFYLDHRTVDAKHAIITDTHVTPASVHDSQPYLDRLDRQRERFEFKVEAVGLDAGYFTPAVCQGLEERGIAGVMGYRTPNHKPGMFYKRQFKYDAYRNEYVCPQGQALPYSTTNRLGYREYKSNAQICGRCPVRSQCTNSAIAVKVVTRHVWERAKERVDARRLTEWGQRIYARRKQTVERSFADAKQLHGHRYARMRGLRKVAEQCLLAAAAQNIKKIAMLLARKRKKGPAGPDWRFVRMLLRLVSGLRCSFDYPLAANPQS</sequence>
</entry>
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    <accession>Q63SJ6</accession>
    <name>Q63SJ6_BURPS</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
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                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RNA_helicase_HrpA"/>
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        <property type="entry name" value="DEAH_box_HrpA"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0347">Helicase</keyword>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="229"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1297" mass="144420" checksum="4B9D6FDCCBCDB38B" modified="2004-10-25" version="1">MPVSGKRDEIARAIAAHPVVIVCGETGSGKTTQLPKICLALGRGLGAGGAGLIGHTQPRRLAASSTGRRIAEELGTPFGEVVGYKVRFTDNLAPGASVKLMTDGILLAETQTDPLLKAYDTLIIDEAHERSLNIDFLLGYLRQILPRRPDLKLIVTSATIDAERFARHFGSDERPAPVIEVSGRLYPVEVRYRPIADDRPAAVRHAEGASSGRDRAKSAREAERDLMDGIVDAVDELCREGPGDVLVFLPGEREIRDAAEALRKHHPPHTEILPLFARLSAAEQERVFKASNARRIVLATNVAETSLTVPGIRYVVDTGLARVKRYSYRNKVEQLQIEPISQAAANQRAGRCGRVADGVCIRLYEESDFAGRARFTDPEILRSSLASVILRMKSLHLSAIESFPFIEPPPGRAIADGYQLLNELGAVDDENALTPLGRELARLPLDPRVGRMILAARDQQALREVLVIASALSVQDPRERPVDAQEQADQAHRRFADERSEFLQWLRIWAWFEEAVAHKKSNRQLVDACRQHFLSHLRLREWRDVHSQLLTVVREHGWRLNEADATFEQIHLSLLTGLLGNIGFKAEDEPHYLGARGIKFHLWPGSALVKKAGRWVMAAELVETSRLYARCIAKIEPEWIERIGAHLLKKSLSEPHWEKRPAQVAAFERATLYGLTIYHRRRVAFGRQDPARARELFIRGALVDGEFDTKLAFFAHNRKLLADIEQLEHKSRRQDVLVDDELIHAFYDQAIPAGIHTGAAFERWYRDEVSKSGQPEDKLRLLYLSRDDLMRHEAAGVTTELFPKRVTMAGVEMALAYHFEPGSPRDGVTLAVPLFALNQVDARRAEWLVPGMLKEKAHLLLKSLPQKLRRHCVPLPEYAAGFVERAGRERFGAGGLVDALIADVREQTQVATKTSDFKLETLPAHLFMNFKVIDEHGRQLAMGRNLAQLRAELGAQAQQHFQKIAAAATLAPAGEPAAAAAGASGARARRVPLGAPPRAAEPAAQAGAAAGATALYENLTTWNFGKLPELLEIRRRGETLFGYPALVDRGTHCDVEVFDSPDEAARIHRAGLRRLFALQLKEPIKYLEKNLPGLREMAIQYMSLGTQDELRDQLIATALDRACLQEPLPADDASFHARRDEGRSRLNLLAQEIARLVGQILAEYAGLAKKLAQAKPFPAAHADMQGQLAALVGKRFVVDTPYAQLAHFPRYLKGIALRIDKLKADPARDARQAAELQPLAQHYQRSVAQRGGVADARLAEFRWLLEELRISLFAQELRTPMPVSVKRLYKVWESMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SQ6</accession>
    <name>Q63SQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192762.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108860.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2264"/>
    <dbReference type="ESTHER" id="burma-q62j15">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36267">
        <property type="protein sequence ID" value="CAH36267"/>
        <property type="gene ID" value="BPSL2264"/>
    </dbReference>
    <dbReference type="GeneID" id="56596058"/>
    <dbReference type="KEGG" id="bps:BPSL2264"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3166"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGLMPVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="33168" checksum="5A782FA25F7EC317" modified="2004-10-25" version="1">MHSTQSVSDFVTVRGVKLHVRRWGRPDAPTLYMLHGWMDVAASFQFVVDALAGDWQVIAPDARGFGLSDWPVAAQGGGHYWFHEYLADLEALIDHYTPDGEVNLVGHSMGANVVCLYAGARPQRVRRVVDLEGFGLAPARAEQAPRRLAQWLDELRAPPELKRYASLEDVAARLVKTNPRLEPRRAAFLAAHWSTRDADGRYRLLADPAHKLRGPLLYRLDEVMAIWSKVRAKVLHVEAVDSPTLAFLAGEIPIAEFKARFAAFADWREKRVEDAGHMVHHDQPEQIAALIEAFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SS2</accession>
    <name>Q63SS2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ</fullName>
            <ecNumber evidence="5">2.1.1.200</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA Cm32/Um32 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trmJ</name>
        <name evidence="8" type="ordered locus">BPSL2249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42936"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10290"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42932"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10289"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.200" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544079.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108844.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2249"/>
    <dbReference type="EnsemblBacteria" id="CAH36251">
        <property type="protein sequence ID" value="CAH36251"/>
        <property type="gene ID" value="BPSL2249"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2249"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2554"/>
    <dbReference type="eggNOG" id="COG0565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="303" mass="31944" checksum="2EF6970242976400" modified="2004-10-25" version="1">MESQQKPSAPPSGAATSRPARTARGGFTSTRFVLVEPSHPGNVGAAARALKTMGFSRLVLVAPRVPRVQSDPEALAMASGADDVLASAHVVPTLADALNGVQWSLALTARSREYGPPRLAPRAAVASALQQVRTGDIALVFGNERTGLSNEHVERCSAIAHIPANPAYSSLNLAQAVQVLAYELRVALLEDDEAAVPPDAALGTLAQSDEIERMFVHLENALIALDFLDPRNPKKLMPRLRRLFARTGLEREEVNIVRGIAKHILLKAGGANARAGASGEGNGNGESATGDADYSGRDVSRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SU2</accession>
    <name>Q63SU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative siderophore non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108824.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2229"/>
    <dbReference type="EnsemblBacteria" id="CAH36231">
        <property type="protein sequence ID" value="CAH36231"/>
        <property type="gene ID" value="BPSL2229"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2229"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2529"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WNTQLRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2676"/>
            <end position="2747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1158"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="3007" mass="325521" checksum="F538BFD08F009FAB" modified="2004-10-25" version="1">MARSGAHPLADGGRAVVLQDGTHKIGLHMNQSYDVVETALRLRAGLAEHLGAAGPDVDEPLVDHVGGALPPALLVDVVRACGGMHATRVDVLGCATLRELAAWIERTGGAAREPRAAPDAAPNGARPEAPLAPEDADDAPASPAQEDLWLAAQVQEEGAAYHLSIALRFDAPVDDASMRRALVEMIARHPSLRTTFRRDAQGLRQCVRAAAQAEVDWSEAVLPAPDEAGERESGLRDALTRFAQSRFDLHAGPLLRARLHRGAPDCDVVQIVVHHIVFDAWSRMVVSREIVDAYHALRAGRAIAWSAAAASPGAFARGQRDALTPQRVARLREYWRVQLAGVPPVLDLPTDFTRPAVRDGIGATALRMLPAALAERLAAVGARHGASLFMTLMAAWQILLWRCSRQHEFAIGTPMAARDAGAFESTVGYLVNTVVLRASVRADEPFGGLLARVAQTVLDAHEHKALPLREVIELAGADRNPSHTPLFQAMFEFHNERPGVEAAQAAPVRAVPHDVGAAKYDLSLEIAYRHDGLACTIEYATALFARSSIDGLLAQYEALLEQIAAMPDAPVGSLSCLPDGERERVTRTWNATAFERTGSPLIHARFDARVRACPAAIALRMDAATMTFAALGERVDALAGRLLERTGGEPERIAICLERSFDMVSAILATLKAGCAYVPIDPQLPADRVAFMLSDSAAALLLTIEPIRRERLASFDIDTLCLDAPAPPRAAPPRAAPAVDPHAAAYVLYTSGSTGKPKGVAVTHANVTNLLDVMEASYPVGAHDRYLLKTNYAFDVSVPELFGWFVGDGSLAILAPQAEGSPDLIVEALLRHGVTHLNFTPSLLRQFVTEAAADARFARGHRLRHVFVVGEELTSALANDAWHALRPATIYNMYGPTETTVFATGYAHTAPIPNGRVPIGRALGNMRVYVLDERMRPMPIGMPGDLYIAGDGVARGYLNRDELTAERFLPDPFTPGGRIYMTGDLARWTRDGMLEFLGRTDQQIKIRGYRVELDEIASALNAHPLVGEAAVILKREPDGDARLVAYVVPAEGAAAAPSRDERARLRDALVGALEQRLPDYMVPADYAFAHALPKGITGKLDRKALEALPVERPARDAALGAVAPRNDTQRALCAIWQAVLRVPALGVTDNFFAVGGDSILSIQAAARAREQGIVFSARDIFRHQTVELLAAHVRWQQAPDEARRASAGDMPLLPIHHWFFEVDSTHVDHYHQSRLLDVPAGVDAAFVRAWLAALVARHDALRLRLRDTPAGWRAHFAEAPHADASARLMVCDVAWAGAPDAALDAFFADARRGVRLADGPLFVAALVAAGATGRGRLLLIGHHAVVDGVSWRVIVADLRRTFAQWPALRPDAPGPASDAYQAWARALVAAADSPALHAERAHWLRVLRAPAPALRLDRAAGGDATRRATRIGAVSLNAADTRALLADTHRAYRTQTIELLLAGLLLAFRRWQGHDALRIALEGHGREADALAHYGAERGLPDVGETVGWFTSYYPQWLTLAGAASAPAPAADSVAAAIMAVKTQYRATPRHGIGYGILRYVAGDPELAAEAAAHAPEIVFNYLGQFDVANDEAAGIAVLDLSSRDDIAAARSREHALGIDGGVKDGCLAFEIDYSGAAFDDESIAAFGAHFMHALREIAAHCKACAAWRPTPEDFPLAAVTQAELDAWHARHPSLETLYPATAIQRGMVFHSLLPKQASAYTNQVHARVGGGTFDAARLRHAWQTVLERHAALRTAFVGFEREQPLQIVLAHAACPWRDIDHRHLAPEARDAAFAALLAADKAAPFDFGRAPLMRFHLVRDDDAHYRFIWTYHHAVLDGWSVQLVWSDLLRVYEALAAGRPAALPAAVQFDAVLAWRQRHASDADKRYWREQIGARTQRTVLDIEQAGLAAASPAAPAVVERSLDEAASERLATAARACRVTLASVLQAAWALLLARHSGETAPVFGVTSSGRAIDVPGVETIVGPLIATVPARVDVDAALPLGDWLRAVHERHVEREAHAQLELVDILRESGVRGGQPLFDSLLVVENYPLAEPSAARILGLRDYGYAEDTHYGLTVSATPGPRLRVEINFDRSRYHIEDIEAMADNLKAVLTRVPDDLARPAGDVLGGADAARAQAGAEGEPRLSRVSRQGELRLGRHLVPHLVEDHAAATPERRALVYNERAYSYGELNRAANRIANRLMQAFPDLGTDALVGVRVSRSDRLVLTVLAIWKIGAAYIPIDPVLPGQRMREMLELAGAKALVVDAAVAAAEPAVAGVPRIAFDDLVQDDPCLEDNPDVHLSGNDLSYVLFTSGSTGKPKGAMIEHIGMLNNIANKALDLEMDEDSRVAQNASMSFDVSVWQMFIALTKGGATFVYDERAVNDIAGLIRRMAADGVTILEVVPTYLIAVVEYLEEHPECVRPASLRFLIVNGETVDATLIRRWFALFPATKLINAYGPTEASDDITHHIMSPGDEIVNPVPVGRALANFDLYVVDDELRPVPIGTRGEIVATGVGIGRGYIGMAGATAQAFVKSPFPDRYKGRLYRTGDLGEMREDGVLMFHGRKDRQVKIRGMRIELDEVEASLRAIAAVRQAVVLAIRPENREAFLCACVVPLDGAREEIVDALKAKLPPYMVPSVFRFERELPQLPSGKVDRNRLREQCLNETPRASEHALAPRSPLERRLAEVFGEVLGHDAFGVLDDFFALGGDSFKAIRIAAKYGPPLEVTDIYDHPTIEALAAHLERAPRAERSIVQMAGDPATAKAALVCIANAAGGPVNFVEMSRAMAEQAGEFAVFAVKLPRNAVDSDAAMLAEVTRLANAVCDDLLAASGLPIIVFAQCNGSALAIAVARELTRRSADLRALCMGGALMRTASGKRDARTDDEILGFLGGIGSTLPGRPDERAFFLHEFRYDSWLADVYYNHLVDEASRGALTPLDIPVWCLVGTDDPLVSQYETRHRDWLRIGRSVKLAEFAGIGHYLLRDCPHALARTLGQAWEAVSRRSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV6</accession>
    <name>Q63SV6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cysteine synthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545916.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108810.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2215"/>
    <dbReference type="EnsemblBacteria" id="CAH36217">
        <property type="protein sequence ID" value="CAH36217"/>
        <property type="gene ID" value="BPSL2215"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2215"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3230"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GSWCPDQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="354" mass="38569" checksum="FEB666335A70128B" modified="2004-10-25" version="1">MTYDAASNRKIRATVSGAMAEPRIVQLAPNLYAVALEVMKIIPAKHIIEQALRDGRIDRDTLVVESSSGNFALGLAVVCREQGLKLRIVGDPAIDPKLRGMLHNLGAEVDIIEKPDALGAYQRLRLARVAQLLGAHPNAFWVQQYDNPGNPDAYRPLAERLLDEMGPAFDLVACVGSGGSSVGLATHLRRHSEQVRVTGVDTFNSVLFGLPDGKRTLRGLGNSIMPKILDHTQFDEIHWLASPQANLAAIELHARHGLFCGPTSGAAYRIASHQAARQPARKTLFVAPDTGYRYQDTIFDARWLKANGEIAGAPCTAPHRVERLDQVDPAREWACIGWGRKSLAEQPGLVALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SZ5</accession>
    <name>Q63SZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL2176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531442.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108771.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2176"/>
    <dbReference type="EnsemblBacteria" id="CAH36178">
        <property type="protein sequence ID" value="CAH36178"/>
        <property type="gene ID" value="BPSL2176"/>
    </dbReference>
    <dbReference type="GeneID" id="56529018"/>
    <dbReference type="KEGG" id="bps:BPSL2176"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3275"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="313"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="572"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="646" mass="71014" checksum="305F0B0FE0889170" modified="2004-10-25" version="1">MIRFNQFSLARGTKPLFDATSFTLNPGEKAGLVGANGAGKSTLFAVLRGELHADAGDFSMPPAWRIAHVSQETPAVERSALDYTLDGDAALRAIEARIAQASAAHDGAAEADAHAAFADADGYTAPARAEALLLGLGFTLAQTREPVASFSGGWRMRLNLAQALMCRSDLLLLDEPTNHLDLDAIVWLEDWLHRYPGTLVIISHDREFLDAVCDVTLHLENRQVKRYGGNYSQFEVLRAQQLELQQSAYEKQQKTIAHLQSFVDRFKAKASKAKQAQSRVKALEKMERIAPAHIASPFTFEFRTPDSAPNPMLVMENVRCGYRADDGGEIPIVERVALSIQNGQRIGLLGANGQGKSTLIKTLAGTLAPLSGELRTGRGLTIGYFAQHQLETLREDDSALAHLARLAPDTREQELRDFLGGFNFSGEMATAPIAPFSGGEKARLALALIIWRKPNLLLLDEPTNHLDLETRHALTMALAQFEGTLILVSHDRHLLRATTDQFMLVAKHRLQPFDGDLDDYRDWLLQHAAEQRAAAKAACGPAGDADDGAPAVNRKDQKRQEAEARQRLSQLKKPLQARITKIEKEMERLHAQKAELDAFVADPASYAADQKTRLTEAIRKLGDVNGQLETLEADWLGAQDELEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T58</accession>
    <name>Q63T58_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptonal regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521226.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108708.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2111"/>
    <dbReference type="EnsemblBacteria" id="CAH36114">
        <property type="protein sequence ID" value="CAH36114"/>
        <property type="gene ID" value="BPSL2111"/>
    </dbReference>
    <dbReference type="GeneID" id="56529085"/>
    <dbReference type="KEGG" id="bps:BPSL2111"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3358"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHERVHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="309" mass="35253" checksum="0AD993CB8B8F4272" modified="2004-10-25" version="1">MSQQREAIDTYLLRVLHTLLMERSVTRAAVKLNQSQPAISAALRRLRDITGDPLLVRGKSGMVPTEYGLRLLEPVQNALREIERIKFQQHNFDPATSIRCYRIGCPDYLNVLFVPTVVERFRQAAPNATLEFHSLGPAFDYELALEDGKLDIVVGNWPEPPEQLHLSNLFVDEIVCLMSNSHPFAKRGGLTLDQYLNAPHLAPTPYSVGQRGAIDVHLARERLKRHVVVTLPYFNLAPYVLVKSDLIFTTTRLFADHYAKFLPLSVVPAPLDFPPMQYYQLWHERCHYSDEVRWLRGLVAEATRTLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU9</accession>
    <name>Q63TU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521640.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108467.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1868"/>
    <dbReference type="EnsemblBacteria" id="CAH35867">
        <property type="protein sequence ID" value="CAH35867"/>
        <property type="gene ID" value="BPSL1868"/>
    </dbReference>
    <dbReference type="GeneID" id="56595660"/>
    <dbReference type="KEGG" id="bps:BPSL1868"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4002"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QWEAGYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="219" mass="23655" checksum="56C257C36AED04A5" modified="2004-10-25" version="1">MPITSLLAQSLPVLLQGALLTVKFAVLSMLFGLVGAVALALMGIGRSRVLAGLARAYVSVMRGTPLLVQIFVVYYGLPSLGVSLDPTPAGVIALSANVAAYMSESMRGAINGIDKGQWLAAYSLGLSWRQTLRYVIGPQALRIAVPSLSNSLISLIKDTSLVSVITVTELLRSAQEIIASTYQPLPLYLAAAAVYWVLCQILEWVQRWYERRLALPSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U33</accession>
    <name>Q63U33_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative iron transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205071.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108383.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1783"/>
    <dbReference type="EnsemblBacteria" id="CAH35782">
        <property type="protein sequence ID" value="CAH35782"/>
        <property type="gene ID" value="BPSL1783"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1783"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3891"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MFPYQIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="706" mass="70587" checksum="9270888CC9C032C1" modified="2004-10-25" version="1">MTALAVRKRLRHGGRAPEPSPASRAAAPGRVGAIAGALVALIVVTAAMRLAPELRAWLAAPAGGDAAQLAHIMLFDLAAPRVAAALVAGGCLAAAGALLQSLTRNPLAAPDLLGITGGAQLGLIAAMLVPALAGHASVPLLFVCGLAAAACVSAAAGGWRATPLRLILAGSVCMLLFSAVTTLLLAFFEQTVVGASLWASGSLYQPGAAGLRDALLWLVAPLAALPLVIRPLDPLALGDDAAAAAGVRVDATRLAGTVVAVGFASVAVSIAGPLSYIGLIAPNLIRQMRGAKASRLGALVPLAALAGGALVLVTDSAVLALGLDATLSTGVAIAFVGTPLMLAMIRRGAAWSGAAQQPAHARAGTRGGARLVRALAVLPWPAVAVLLLAAGAAVLVVGASFGPVWIGPGRWFAALAQRDDLARTVLDLRAPRLLCALLAGALLGASGVLMQSIVRNPLAGPEVLGVTQGAGLATLATLVAWPLAAHGTLVAASLAGGGATLVLTLALNRRHRYAPLAVALTGIVIGTLWTTLAQWLITQESVQPARFVVWLVGGTYGRSWGEAAALLPWGVLAVPALALLARPLDLLALGDEQAAALGLPIAALRPLVLTIATLAACAAVAAVGPVGFIGLMAPHLAAMLGARAHATRLWLAAACGALVLAAADIAARTLLAPREIPAGVLTALIGAPYLLALLIAEARRERRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U98</accession>
    <name>Q63U98_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521514.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108318.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1718"/>
    <dbReference type="EnsemblBacteria" id="CAH35717">
        <property type="protein sequence ID" value="CAH35717"/>
        <property type="gene ID" value="BPSL1718"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1718"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3810"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQAYFLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="44622" checksum="CDAA15E7999C1854" modified="2004-10-25" version="1">MPFSESVADAPSAVEAGYALSTRNVRIYLAYRVLTLAIIDRAIFVIFLMHKGFDAYQIGILQGVFFLANIVTEVPAGMFGDAFGRKRSVLLGLVAYCAYALGVIASDGFVPFVCLYALLGVALALVYGSDTALLYDSLVVDGRVAHFNRVQLRANALGLISGAFAVLAGGLLQKVSWNAVYAAYFAIYAAALGAWGLAIEPPEASAELSAGRKDVTKELFAFIRGHWRSVALPILGFTVFAACTTPFFTFSQALFKENGFSVEHITWFFFAAQMLIGFVYLVMQRTMSFLGFYPVVLASTLLTAIVLAAMFFNVAAVDFTGFFLVMIINPIVTVVANEYFNKRLPSRIRASFLSLIGLCMSLTIAVMYFLYSYLAQYLAIYKVMASTSLIAACACAIFVVARCVDTKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UK2</accession>
    <name>Q63UK2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative transport-related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL1598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555888.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108214.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1598"/>
    <dbReference type="EnsemblBacteria" id="CAH35598">
        <property type="protein sequence ID" value="CAH35598"/>
        <property type="gene ID" value="BPSL1598"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1598"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3656"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RATEIQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022249">
        <property type="entry name" value="DUF3772"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12607">
        <property type="entry name" value="DUF3772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267583" evidence="9">
        <location>
            <begin position="29"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3772" evidence="10">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="809" mass="86110" checksum="22C29F3124CBF417" modified="2004-10-25" version="1">MIRLATFARRVALIGLLHLLCAALPAAAADLASGASVPPAPAISRDGALAELKRVQAALDRIKQQASAATTYKQLDALDESTQALSADVDKLTAALVPTRAQLQAQLDVLGPPPAPGAAPETPAVARQRADLNARKTQLDAALKQAADEKESLANLTQQYSKLRRSLLRDQLVLRSSSILGPRFWAPLFRPSDDDRQELGAFSAQIGQVLAAAWEPGRRLGTALLLAAALAVWTLGRRLAERALAWFSLTKLPETRVRRSALATSIALSSVVTTGIAVQFVYLALTRDYALSSALQDFADELAKLALTCALIAGLGRALLCTHHPSWRLPALADEVALAMRPFPAILAALLLVAGALEELNRTADTSLQVTLFGRGIVSLVVVVTIGASLLRANRARTALAAAGEPPEARSTLAGLIHAGVTLTVVAALAALLIGYISVARFLTYELVWFEIVIGSVYLLTRLTRDAYASAFAANLSSGRLIKHLFGLNDSHLDQARTVLTGISTSVLLLVAVIALLTGGFGTTPNDLLVSVISMFGGDKLQRLNIVPARILNAALALAIGIYLLRSVRRWLDNELLPAIGLDQGMRASLVTLFSNLGYVALVLLALSLLGVKWDNLAWIVSALSVGIGFGLQEIVKNFVSGLILLTERPVKVGDMISISGVEGDIRRINVRATEIQLSDRSTVIVPNSQLISQNLRNVTMGNSTQGVATLMLTFPLNTDPEQVRDLLLDAYREHASVLEKPAPSVTFSQLTPDGITLSVTGYVGSPRIAAATKSDLLFEILKRLRAAGIALSNPQTLMVQNLPPPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UN2</accession>
    <name>Q63UN2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521369.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108184.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1564"/>
    <dbReference type="EnsemblBacteria" id="CAH35565">
        <property type="protein sequence ID" value="CAH35565"/>
        <property type="gene ID" value="BPSL1564"/>
    </dbReference>
    <dbReference type="GeneID" id="56529289"/>
    <dbReference type="KEGG" id="bps:BPSL1564"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3611"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CRYLDCQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="74" mass="7972" checksum="923967C67641A83E" modified="2004-10-25" version="1">MPIIVKLDVMLAIRKVRSKDLAAAVGITEQNLSLLKQGKVKGIRFATLEAICRHLDCQPGDLLAFEDGPGADAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UR8</accession>
    <name>Q63UR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527154.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108148.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1528"/>
    <dbReference type="EnsemblBacteria" id="CAH35529">
        <property type="protein sequence ID" value="CAH35529"/>
        <property type="gene ID" value="BPSL1528"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1528"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3568"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CIDKAKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267595" evidence="3">
        <location>
            <begin position="31"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="249" mass="27428" checksum="1F0F419D4D7E7530" modified="2004-10-25" version="1">MIRSFPTTLPTSRFSVVAFAVALAATLSCAPVAGVAQTPAPAATSPAAAADAGAFAAPANFDARQKVLNQRTAENDYRYAVAQHNCYSTFFVNHCLDKARETMRAERANISQEQLALDDEQRAVRAQERDRQLALKEAERQAQAPQRAADEQANAAAYEGKQHENALKRAQRDAQAPQRAANQQAYDAKQAEFQRKLDAAHAQAAKDAQQRAENAARYEQKQRDAAQHKADVDERQRQAAEKAKQKQQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US3</accession>
    <name>HISZ_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisZ</name>
        <name type="ordered locus">BPSL1523</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192327.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108143.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63US3"/>
    <dbReference type="SMR" id="Q63US3"/>
    <dbReference type="STRING" id="272560.BPSL1523"/>
    <dbReference type="EnsemblBacteria" id="CAH35524">
        <property type="protein sequence ID" value="CAH35524"/>
        <property type="gene ID" value="BPSL1523"/>
    </dbReference>
    <dbReference type="GeneID" id="56595738"/>
    <dbReference type="KEGG" id="bps:BPSL1523"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3561"/>
    <dbReference type="eggNOG" id="COG3705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELVMPPM"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242827" description="ATP phosphoribosyltransferase regulatory subunit">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <sequence length="382" mass="41779" checksum="274B45DC25D61318" modified="2004-10-25" version="1">MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGNELRLRTFKLVDQVSGRTLGLRADMTPQVARIDAHLLNRQGVTRLCYAGPVLHTRPRGLHASREQLQIGAEIYGHAGLEADQEIQQLMLDALHLTGLKKIRLDLCHAGVLAALFARDAAAAERGEALYEALAGKDVPRLNELTDDLGADTRAALRALPRLYGDASVLDDARRLLPALPEIARALDDLAHLAAQVKDAEVAIDLADLRGYAYHSGAMFAAYVDGVPNAVAHGGRYDHVGQAYGRARPATGFSLDLREIARISPVEARGAAILAPWKQDDALRAAVGALRDAGEVVIQALPGHDHVLDEFACDRALVERDGAWVIEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V53</accession>
    <name>Q63V53_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205000.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108013.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35391">
        <property type="protein sequence ID" value="CAH35391"/>
        <property type="gene ID" value="BPSL1390"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1390"/>
    <dbReference type="OMA" id="KMGKANT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="131" mass="14011" checksum="B808402AD199D491" modified="2004-10-25" version="1">MELKMGKANTIELTNNTSFTLVLHTIYANTGNWSGDYPPAYLRPNDTLIFTSTLDGKGDLNGSARFDILDTAVKRCPDATYVQLNWDNPVGADNGGSSSVVGATAQFFNVNGPTISGDYGHPTFSWSVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD6</accession>
    <name>Q63VD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554495.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107930.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1306"/>
    <dbReference type="EnsemblBacteria" id="CAH35303">
        <property type="protein sequence ID" value="CAH35303"/>
        <property type="gene ID" value="BPSL1306"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1306"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1459"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHAFHEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="323"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="454" mass="50501" checksum="87A515E11C73C974" modified="2004-10-25" version="1">MIGTIARLYTACLLIGFALVPAFLIAYVRFFIDPRLVFENHQFHELAIAAATLEGLFVTYVTWRCYLASGEPLLRWLTLGFLGFALIYSLHGAFTGMAHQNIWLFLLYGPASRLVMSILLLVGQLSYFRDADPPERRTHLSMWLPWIAGYVVVCFAVAAIAYSPIAGHLWTRASMEGGAMIVSLVNVALLLVRRIRTPLMLVYGISVTSFALSSIAFIFGKPWNHMWWLAHAVFAGGFFMLSFGVVQALMTTRSFATVYSQQDLMARLAESMARTEGVLQELKRTNQKLEHLATTDPLTGASNRRKFIEQMQSEIARAKRDGTAFSLLALDLDNFKTINDNYGHQVGDVVLRNFVRQCLAAIRPYDHIARVGGEEFMVLLPRMLADTASGIAERVRTTIANASFGIDGKHTPVTVSIGVSQYGRDGDTVDEILSAADKLLYRAKNEGRNRVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VI9</accession>
    <name>Q63VI9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL1256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="4">Binds 2 heme c groups covalently per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538458.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107877.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1256"/>
    <dbReference type="EnsemblBacteria" id="CAH35250">
        <property type="protein sequence ID" value="CAH35250"/>
        <property type="gene ID" value="BPSL1256"/>
    </dbReference>
    <dbReference type="GeneID" id="56526602"/>
    <dbReference type="KEGG" id="bps:BPSL1256"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1390"/>
    <dbReference type="eggNOG" id="COG2863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATHKGIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024167">
        <property type="entry name" value="Cytochrome_c4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000005">
        <property type="entry name" value="Cytochrome_c4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266373" evidence="8">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="9">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000005-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000005-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="238" mass="25242" checksum="D0D50C89090E9327" modified="2004-10-25" version="1">MTVTSRPTAVLAVLCGLLSQTALSQEPQTERAPDTMEARVLACAACHGRQGEGTSNDYFPRLSGKPAGYLYNQLVAFRDGRRKYPPMNYLLAYLPDAYLRKIADHFASRRPPFPTIAAPAAAPAVLERGRLLVKSGDPSHKIPACASCHGASLTGMEPAVPGLLGLHAEYLSAQLGAWRYGTRTSIAPDCMQQVASRLTDTDVTAISAWLASQPAPANPSPAPAGSLDMPLACGSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VR4</accession>
    <name>Q63VR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107802.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1180"/>
    <dbReference type="EnsemblBacteria" id="CAH35175">
        <property type="protein sequence ID" value="CAH35175"/>
        <property type="gene ID" value="BPSL1180"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1180"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1305"/>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYWGGPT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015671">
        <property type="term" value="P:oxygen transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019795">
        <property type="entry name" value="Globin_bac-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01213">
        <property type="entry name" value="GLOBIN_FAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="17190" checksum="C8E8070CBADDDACF" modified="2004-10-25" version="1">MFFDSTDSTDSRMTDVTDDAPSPPTAFELVGGEARVRELVDRFYDLMDLEPEFAGIRALHPPTLEGSRDKLFWFLCGWLGGPDHYIERFGHPRLRARHLPFPIASSERDQWLRCIAWAMQDVGLDEPLRERLMHSFHDTADWMRNRPG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VS9</accession>
    <name>Y1165_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein BPSL1165</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL1165</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185607.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107787.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VS9"/>
    <dbReference type="SMR" id="Q63VS9"/>
    <dbReference type="STRING" id="272560.BPSL1165"/>
    <dbReference type="EnsemblBacteria" id="CAH35160">
        <property type="protein sequence ID" value="CAH35160"/>
        <property type="gene ID" value="BPSL1165"/>
    </dbReference>
    <dbReference type="GeneID" id="56595095"/>
    <dbReference type="KEGG" id="bps:BPSL1165"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.373"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000175778" description="Probable transcriptional regulatory protein BPSL1165">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <sequence length="242" mass="26122" checksum="0837E70982928550" modified="2004-10-25" version="1">MAGHSKWANIKHKKAAADAKRGKIWTRLIKEIQVAARLGGGDVNSNPRLRLAVDKAADANMPKDNVKRAIDRGVGGADGANYEEIRYEGYGIGGAAIIVDTLTDNRTRTVAEVRHAFSKFGGNMGTDGSVAFMFDHVGQFLFAPGTSEDALMEAALEAGANDVNTNDDGSIEVLCDWQEFSKVKDALEAAGFKAELAEVTMKPQNEVDFTGEDAVKMQKLLDALENLDDVQEVYTNAVVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VT8</accession>
    <name>Q63VT8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936880.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107778.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1156"/>
    <dbReference type="EnsemblBacteria" id="CAH35151">
        <property type="protein sequence ID" value="CAH35151"/>
        <property type="gene ID" value="BPSL1156"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1156"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16831" checksum="1F52B4DAE56CAA1D" modified="2004-10-25" version="1">MKGIKGEVFEKEFSNLQVTAYADLALWPLIDLPITIACAHALSAIHADAAGCVNIAWTYVQDASYWHGASFALAKIADDSPTKSITEVARNAALKKNEENREIKKEAFKWLDDHFGLENLTIDDAAESLGKIVPMKFSTRRSYVIEWKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W26</accession>
    <name>Q63W26_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4399 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107690.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1067"/>
    <dbReference type="EnsemblBacteria" id="CAH35062">
        <property type="protein sequence ID" value="CAH35062"/>
        <property type="gene ID" value="BPSL1067"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1067"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1158"/>
    <dbReference type="eggNOG" id="ENOG5032RWS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPQVLHF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025512">
        <property type="entry name" value="DUF4399"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14347">
        <property type="entry name" value="DUF4399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267212" description="DUF4399 domain-containing protein" evidence="1">
        <location>
            <begin position="41"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4399" evidence="2">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16225" checksum="8C2313AC8BF0EFE2" modified="2004-10-25" version="1">MRGVSFDGLSTQKERAMLYNKWLAGAFTAAALFASASAHAEARVYFVEPADGASVSSPVHVKFGLEGDIVLRPAGDMTPHTGHHHLLIDGKPVARGDVIPANDHSLHFGKPQTETEVRLSPGRHTLTLQFGDGAHRSYGPEMSQTITVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W65</accession>
    <name>Q63W65_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192390.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107651.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1025"/>
    <dbReference type="EnsemblBacteria" id="CAH35020">
        <property type="protein sequence ID" value="CAH35020"/>
        <property type="gene ID" value="BPSL1025"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1025"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1113"/>
    <dbReference type="eggNOG" id="COG3146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HFEVCYY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007434">
        <property type="entry name" value="FemAB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04339">
        <property type="entry name" value="FemAB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="392" mass="44304" checksum="9F5541A92EE57523" modified="2004-10-25" version="1">MKHERRDYRMGILTSVLDASAAEWDALVARAPRPTPFLKHAFLSALHRAGCATDGTGWTPRFVTLADSATDALVAAAPVYAKRHSYGEYVFDWAWADAYQRNGLPYYPKLLCAVPFTPVQGSRLLAVDDDSRRRLAATLVALAEQSDVSSLHVLFPTGDEARALADMGMMLREGVQFHWLNDGYRDFDAFLGTLEQKKRKNIRAERRKVADAGVTLRRVRGEDATDADWRFFARCYRQTYREHFSSPYLNLEFFREIGATMPENLLLVIAERDGRPIASALAVYQRGEAGGGTLYGRYWGALEHVPCLHFETAYYQLLEFCIEERLDTFEGGAQGEHKLARGFMPTVTHSAHWLAHPAFADAVGHFLAQETNQIHAYVDELREHNPFRAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W79</accession>
    <name>Q63W79_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526328.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107637.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1009"/>
    <dbReference type="EnsemblBacteria" id="CAH35005">
        <property type="protein sequence ID" value="CAH35005"/>
        <property type="gene ID" value="BPSL1009"/>
    </dbReference>
    <dbReference type="GeneID" id="56596180"/>
    <dbReference type="KEGG" id="bps:BPSL1009"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1094"/>
    <dbReference type="eggNOG" id="COG5430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TVWGSTT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007893">
        <property type="entry name" value="Spore_coat_U"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05229">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00972">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266396" evidence="1">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SCPU" evidence="2">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="17473" checksum="3C4E45AAD6E1BC9D" modified="2004-10-25" version="1">MYFLKHPLLSALAAAVLVATPSFRPATAATATATFTVSLTIQANCTISANALSFGTNGVLATAVNQQTTLSVTCSNTTSYNVGLDAGNVSGSTVSSRLLAGTTTGNTSTTVSFQLYQDSGHTTIWGNTVGTNTVSGTGNGTAQTLSVYGQVPAQTTPKPDTYESTVTATITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WE2</accession>
    <name>Q63WE2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL0945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554541.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107574.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0945"/>
    <dbReference type="REBASE" id="10396">
        <property type="entry name" value="BpsKORF945P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34941">
        <property type="protein sequence ID" value="CAH34941"/>
        <property type="gene ID" value="BPSL0945"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0945"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.632"/>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VQIIVEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="294"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="787"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115778" checksum="7D728E71D45E3AAB" modified="2004-10-25" version="1">MSNLHQEHHFEAEICQSLSTNGWLYAEGDAAHYDRTNALFMPDLLAWIEATQSDTWQRLSKTHGPALHDRLAERVRKSLNERGTLDVLRRGVEMLGLKEPLSLVQFKPALAINPVIQQHYAANRLRVVRQVRHSQNQSQDALDLVLFVNGIAVATAELKSDFTQSVQDAVDQYRFDRQPQPKGGQVEPLLSFPGGALVHFAVSQTEVMMTTWLAGLGTRFLPFNRGNQGAAGNVPNQDGFATAYLWEEVWARDSWLDILHRYLIGKRDEKKQLKAVIFPRYHQLDATRRLVADVLAQGSGQRYLIQHSAGSGKTNSIAWTAHFLADLHDDNHHKLFDSVLVVSDRTVLDAQLQEAIFDFERTTGVVATITKEHGSKSAQLGQALKDGKKIIVCTIQTFPFALQAVQELAATEGKRFAVIADEAHCSQTGEAAAKLKQLLSAEEWADLQDGGEIDTEALLAAQMEARTGAKGLTYVAFTATPKQKTLELFGRPGPDGLPEPFHVYSMRQAIEEGFILDVLKNYTSYKLAFRLAHNGQEYDEKQVERSAAMKGIMQWVRLHPYNIAQKVQIVVEHYRENVQPLLDGKAKAMVVVASRKEAVRWQKAIRAYIEKRNYPLGVLVAFSGEIDDPESYPAPVTEASKELNPGLNGRDIRDAFAEPEYHLLLVANKFQTGFDQPLLCGMYVDKMLGGIQAVQTLSRLNRAHPGKDTTYILDFVNEAGDILKAFKTYYETAELEATTDPHHVYDLRAKLDAAGYYDDFEVDRVARVEFDPKGTQAQLQAAIAPVTDRLLKRYKAAQQDKAAAEAQHDEKAAQAARDTLNALVLFKNDMGAFVRLYAFLSQIFDYGNTDIEKRFLFYKRLIPLLEFGRERDTVDLSKVTLTHHSLRNTGRQPLNLGHGEAPKLPPMDAVGSGAVQEKEKAFLDEIIQKVNGLFDGELTDDDQLVYVNGVLKGKLLENELLVQQAASNSKEQFANSPDLTDALMRAIIDAFDAHTTMSKQALDSPRVRDGLKDILLGPAQLYEALRARSGASRQPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WH8</accession>
    <name>Q63WH8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transmembrane fatty acid desaturase</fullName>
            <ecNumber evidence="10">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186237.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107538.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0911"/>
    <dbReference type="EnsemblBacteria" id="CAH34905">
        <property type="protein sequence ID" value="CAH34905"/>
        <property type="gene ID" value="BPSL0911"/>
    </dbReference>
    <dbReference type="GeneID" id="56594767"/>
    <dbReference type="KEGG" id="bps:BPSL0911"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.671"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQNTREW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="9">
        <location>
            <begin position="278"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="398" mass="46195" checksum="B09CB54AA82973E2" modified="2004-10-25" version="1">MLNSLLDFLSNGLLRFSWWQIVLFTLAVTHVTIVGVTVYLHRCQAHRALDLHPIMSHFFRAWLWMTTGMLTGQWAAIHRKHHAKCETEEDPHSPQTRGIWKVLLEGAELYRAEAKNEETMRKYGHGTPNDWLERNVYSKYPILGVSLMMVIDVALFGLVGLTVWAVQMVWIPFWAAGVVNGLGHFWGYRNFNAADASTNLFPWGIVIGGEELHNNHHTFATSAKLSNKWYEFDIGWMYIRIMSAFGLAKVKKIAPTPRLAARKTVLDQETLQAVLSNRYEVMARYAKTLKRAYRQELAHLKELGAREKYQLMRGARKWFHKDEAGLDEPQKRMLPEIFANSQKLHTFFQLRAELTAIWERSNASREQLLTQLQDWCHRAEQSGIKALQEFATRLRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WI8</accession>
    <name>Q63WI8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555961.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107528.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0901"/>
    <dbReference type="EnsemblBacteria" id="CAH34895">
        <property type="protein sequence ID" value="CAH34895"/>
        <property type="gene ID" value="BPSL0901"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0901"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.681"/>
    <dbReference type="OMA" id="APDGGMC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="247" mass="26180" checksum="733D587D2706767D" modified="2004-10-25" version="1">MTTIKTGDASGAGCAAAARARVAARIMRRALAVLGGAAFAGWFGAAFAASSGTTVPPLDTTPWLASVQAPKTPFFTRASDAQGVSFHFANSGHDVERGREVVVSETADGDMWQGGMVHATYIDAAGVETSGWLVRSHLRRVKKPVPPPTWDGRWRSSAGARRLIVHGERISYSFAGGGGTGGAQPRVEMLLRMRPVSDDEAVLSRMQAPDGGMCDLAVRRLGDYLIVSARDCFIPGVSPEGILRKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WJ8</accession>
    <name>Q63WJ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BPSL0892a</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107518.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0892a"/>
    <dbReference type="EnsemblBacteria" id="CAH34885">
        <property type="protein sequence ID" value="CAH34885"/>
        <property type="gene ID" value="BPSL0892a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0892a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.694"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LDGHNGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266837" evidence="2">
        <location>
            <begin position="34"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="528" mass="41969" checksum="2678E6A12AF07A9A" modified="2004-10-25" version="1">MDKTKQPPRAAKRCCRATLLAAAAFACCCGSYAAAQEAASAAPSTTTQPRDEAPLSAPLQVVQDAISAGTADVSANASADADVAMPLAEVAPPCSAPGACGAELRLAGGMGGNGEGAGAGGIGSGGDNAGSGRGSSGGANDGNGAVGAAGIGVGGTTGSTAGGTAATGRGNSVGNASGGGTSGGGASGHGTSGRGAAGGGASSGGASGGGTSGGGASGGGASGGGTSGGGASGGGASGGGASGGGASGGGASGGGASGGGASGSGASGSGASGGGTSGGGASGGGTSGGGASGGGTSGGGTSGGGTSGGGTSGGGTSGGGTSGGGTSGGGTSGGGASGGGASGGGASGGGTSGGGTSGGGTSGGGTSGGGTSGGGTSSGAGHGGHGGGTGGGGGHSGGHGNGNGGGASGGSGSGNGHGSGNGGGNGNGGGGGNGGGSGNGTGNGGNNGGGHGNGSSGGGTSGGNGHGNGGGTSSGSGNGGGNGNGSGHGNGGGHGNGNGSGGAGNGGANGVGSGNGGHGNGGGHGNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-06-02" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WM8</accession>
    <name>Q63WM8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">xerD</name>
        <name evidence="15" type="ordered locus">BPSL0863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203577.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0863"/>
    <dbReference type="EnsemblBacteria" id="CAH34855">
        <property type="protein sequence ID" value="CAH34855"/>
        <property type="gene ID" value="BPSL0863"/>
    </dbReference>
    <dbReference type="GeneID" id="56596499"/>
    <dbReference type="KEGG" id="bps:BPSL0863"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.734"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="14">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="13">
        <location>
            <begin position="144"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="333" mass="36616" checksum="F99A09471594A456" modified="2004-10-25" version="1">MARAVHACAADTAGGDAGRAPAPPADRPVDALAASPAWLDSRASIDLFCDAMWLEHGLSRNTLDAYRRDLQLFAQWLAARHAASVDHASEPTLTEYIAARSDGKATSSNRRLSVFRRYYGWAVREHRAAVDPTLRIASAKQAPRFPSTLSEAQVEALLAAPDVDTPLGLRDRTMLELMYASGLRVSELVTLKTVEVGLNEGVVRVTGKGSKERLVPFGEVAHGWIERYLRDARPALLGARAADALFVTARGDGMTRQQFWNIIKRHAQQADVRVHLSPHTLRHAFATHLLNHGADLRVVQLLLGHSDISTTQIYTHVARERLKTLHAAHHPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WY9</accession>
    <name>Q63WY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204879.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107377.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0750"/>
    <dbReference type="EnsemblBacteria" id="CAH34743">
        <property type="protein sequence ID" value="CAH34743"/>
        <property type="gene ID" value="BPSL0750"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0750"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.856"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARTHAYP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="602" mass="66235" checksum="D4156667A0651409" modified="2004-10-25" version="1">MSIQLHRLCVTGPGREPAELLFAGRSYLVFGPTDTGKSYVLESLRYGLGSSGKPRENQFSAGYTRLALQLKSAAGEELTFFRDLVDGSEAVCDGYHQTPPQGAVPGGKPRKIAVVLAQLCGASEKRILVKAGKREGLAAGDLRHFSLFDEIETLDLKPLVGTDTNLLTRRRASGAVILTGHDDEGLTLVASAAKRASAGGYVEAVDEELAILNARLPKDVSSSNVLEAMAKLDTRIQELQTFLRSNENALNELKRDRLHLQREVRRIANERIALTEARTRFELLREKYSSDLQRLEAVETAASVMDVFAPQPCPLCDTPLVVQSRHVHAENDSFALMAEAARAESQKISHLQHGLASAIRELDDDIESLTVDLREVRKREEDNLAEQDALFAKSPGADGVGLSALATQRTEWALVLRDLDRVDVLVKRREEYSQLTKRKTQTVDRNVAEDAVSVCNRIKALLSEWGVPGVEAVHFDEKNVDIQINQRNRISFGKGKRGIFLTAYVVALMEHALQSGNPHLGFVAVDSPVVTYKDPKHGGKGEELLDTTVADRFYEWLAARQESGQVIVLENEEPSTALLEQIPHTEFIGESGGAGRRGFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XB2</accession>
    <name>Q63XB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189681.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107253.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0624"/>
    <dbReference type="EnsemblBacteria" id="CAH34617">
        <property type="protein sequence ID" value="CAH34617"/>
        <property type="gene ID" value="BPSL0624"/>
    </dbReference>
    <dbReference type="GeneID" id="56596683"/>
    <dbReference type="KEGG" id="bps:BPSL0624"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1000"/>
    <dbReference type="eggNOG" id="ENOG502Z7KX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACVQVFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41260">
        <property type="entry name" value="PTHR41260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="31352" checksum="C89DBFA200E302B6" modified="2004-10-25" version="1">MEPLTLVAGPPLSAEDLDTLRRAKLALESPSLTIKLTSVVGAPVEKMIGKLPGFATDKINDATQLALRKCLHIALRTLGKSGGVASAGETPGKPSNLLHKLAVATTGAAGGAFGLFALPVELPVTTTLMFRSICDIARSEGEDLSSAETQLQCLAVLGMGGGFGPLPGAGKDDGQADGDAGGERDKKEEDADIGYFVLRGALAQAVSKASSEIASKGFATHGSAALLRLVQSIASRFSVQVTEQIAAKSIPAIGAVLGATVNTLFIDHFQQAAHGHFAVRRLERKYGQPAVKAAYQAIDASAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XC5</accession>
    <name>Q63XC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolases family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550889.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107240.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0611"/>
    <dbReference type="EnsemblBacteria" id="CAH34604">
        <property type="protein sequence ID" value="CAH34604"/>
        <property type="gene ID" value="BPSL0611"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0611"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1016"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MFANFDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="839" mass="90773" checksum="39A6206524D7E0C1" modified="2004-10-25" version="1">MKSAPDRVARGAAQWTLIATPAGAIARPSELGEAGWCAASVPGTVAQALAAARRFDPAHPYPLGDSDYWYRTTLHGAGPRIVRLNGLATIAEVWLDDTLLLCSDNMYVAHDLPVTLGGAHRLALCFRSLDRHLAEHPPRGRARWRTRLVDTPALRGVRATFLGRMPGWFPAIEPVGPWRPIDIVNPAGAPTIVHDTLRATLDGRDGVLDATLEFAAPLSRTARAQLVCGEHAAPLEATGPRTARATLRIANVTPWWPHTHGEPALYDVGVAIGGATIALAKTGFRTLAVERGADGRGFALSVNGTPLFARGACWTSADPVGLHADAPAYRRALVLARDAGCNMIRVGGTMIYEADAFYALCDELGLLVWQDFMLANFDYPSNDPRFAESLKREAEQFLGRHMARPSIAVLCGGSEIAQQAAMVGLAPDERRVPATEQWLAELCAAHRPDAAYVSDSPHGGVLPFAPREGVTHYYGVGAYLRPPEDARRAGVRFASECLAFANVPCDATLASIGSPAAHEPAWKRAVPRDPGAPWDFDDVRDHYLRALYGVEPARLRSIDPARYLTLSRAVVADLVGETLAEWRRVGSSCAGALVWQFQDVMPGAGWGLVDAHGRPKSAWHALRRVSQPRQILLTDEGLNGLDVHVLNDAPAPLEARIELVALRDGKTPIARAARTVHVAAHAGQCVNSADLLGRFFDFTYAYRFGPREHDVVIASLYASDGALLSQAFHFPERTAPTVFERGDIGLEASAAYRDGRWCVQVQTRTFARYVHVCAPGLLPDIDWFHLAPGAAARIEFAADPHSPAPDHRPPEADAAHCAPPAIEVRALNSNKTIRPRIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XH6</accession>
    <name>Q63XH6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009928823.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107189.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0563"/>
    <dbReference type="EnsemblBacteria" id="CAH34553">
        <property type="protein sequence ID" value="CAH34553"/>
        <property type="gene ID" value="BPSL0563"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0563"/>
    <dbReference type="eggNOG" id="ENOG502ZIXX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHEPIEL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17335" checksum="D7C1AE08E1767F1F" modified="2004-10-25" version="1">MMKIKIHWTTALTLRADPQLIYSPSVLESVDDVPGVYVFARKYGSRVTPLYVGKALNLKGRIKQQLNNLRLMRQIQDWEKNGARVLLLGYLKVHGSQDVGTALDVIERALIEHGLAEGHPLVNVQGTRTPFHTLSFTGNRMSEQVAPRQMFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XJ0</accession>
    <name>Q63XJ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107175.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0550"/>
    <dbReference type="EnsemblBacteria" id="CAH34539">
        <property type="protein sequence ID" value="CAH34539"/>
        <property type="gene ID" value="BPSL0550"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0550"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="224" mass="24709" checksum="210F7918F0183621" modified="2004-10-25" version="1">MDRGRCALLISPSSRRGERPTQIENPGHAPVASFRNGTYMVLIFFSISGVLGAVDRHPSITTRENEPAATRSLESDARLFAETIEPYPGALVVIANDWPLLYDIEFLGQECVPFAQRIVNAVRILGGTKEEAILGFLSSRSVEYIVVTSTDFEFSEVTAARRVNVDSQFGFDAGAADRLRVLLEKAAEAATHPVSTDDIMRATAGNPWVRRLQTYLAHSRQRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XK8</accession>
    <name>Q63XK8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putatve PTS system, EIIa component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195219.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107157.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0532"/>
    <dbReference type="EnsemblBacteria" id="CAH34521">
        <property type="protein sequence ID" value="CAH34521"/>
        <property type="gene ID" value="BPSL0532"/>
    </dbReference>
    <dbReference type="GeneID" id="56593801"/>
    <dbReference type="KEGG" id="bps:BPSL0532"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1116"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NLTGHHI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="119" mass="13665" checksum="B49D32FB195DE495" modified="2004-10-25" version="1">MNLKISGHHLEVTPAIREYVITKLDRVLRHSDQVIDGAVILTVDNHKEKDKRQKAEITLHLKGKDIFVESANGDMYAAIDLLIDKLDRQVVKHMERLQTHAHEPLKHQQAAEQIELPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XN6</accession>
    <name>Q63XN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195347.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107129.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0503"/>
    <dbReference type="EnsemblBacteria" id="CAH34493">
        <property type="protein sequence ID" value="CAH34493"/>
        <property type="gene ID" value="BPSL0503"/>
    </dbReference>
    <dbReference type="GeneID" id="56593869"/>
    <dbReference type="KEGG" id="bps:BPSL0503"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1148"/>
    <dbReference type="eggNOG" id="ENOG5031763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRDITLV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="94" mass="10021" checksum="9EABC16DEF821234" modified="2004-10-25" version="1">MALTLINKKASPDGTPPARPAGWRDRAAAWARGPTLARDISIVLAFKLVLLIALKYAFFNHPQAAHMSLPPAVVAAQLLSATPSAPTEGDRHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR9</accession>
    <name>Q63XR9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550915.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107096.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0471"/>
    <dbReference type="EnsemblBacteria" id="CAH34460">
        <property type="protein sequence ID" value="CAH34460"/>
        <property type="gene ID" value="BPSL0471"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0471"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.528"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRPECAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="32"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="491" mass="52942" checksum="E4132EF5EF750738" modified="2004-10-25" version="1">MRALLGIHLPRLPLDVCAPPSPDGGNGCAVLEQGVVLIADAPARANGVRAGMKRGGVLTLAPGTRLVERDPAREADALRAVALALLRFSPCVALDDEATLVVDVGASLRLFGGLPSLCRQVRATLAALGYAARVAAAPTGRGAWLLARAPGKPGTRRRVVRAASLARALDALPCELLPDARPYAGWFDGLGCRTLADLRRLPRAGLTRRCGPALVAALDRAYGDAVEPLAWMPVPPVFDARLELPERVEYAQAVLFVARRLVVQLCGWLAARQLSLSAMVFALEHERGRQAVPPTPLELAFAEPARDETHFMRVLGERLARVALPAAVIAVRVTATRVESVAPPADDLFPEPGGTREARARLVELLSARLGADNVLRAAPVADYRPEAANRWLPLDAPTGKPVAPGVAPPRPAWLLAPPQPLAMRGNRPFYRTPLRFVSSIERIEAGWFDGQLVERDYRIAQDDYGACYWIYQERGNRAAGQCWFLHGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XW2</accession>
    <name>Q63XW2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198028.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107053.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0428"/>
    <dbReference type="EnsemblBacteria" id="CAH34416">
        <property type="protein sequence ID" value="CAH34416"/>
        <property type="gene ID" value="BPSL0428"/>
    </dbReference>
    <dbReference type="GeneID" id="56594341"/>
    <dbReference type="KEGG" id="bps:BPSL0428"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1233"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYVGEPQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="178" mass="19187" checksum="9C2BF31349525DE0" modified="2004-10-25" version="1">MSPAPAPTSRRAGPLRYVAIAVAAVAIAVAGYFAFNGKSSAPEATFTLLSGQKLSTAADLKGKVYLVNFWATSCATCMQEMPQMVDTYNRFKGRGLEFVAVAMNYDPPMYVANYAQTRQLPFKVALDDGSVAKQFGNVQLTPTTFVIGKDGKILKRYVGAPQFAELDQLLQKALDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YA4</accession>
    <name>Q63YA4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550965.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106911.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0284"/>
    <dbReference type="EnsemblBacteria" id="CAH34272">
        <property type="protein sequence ID" value="CAH34272"/>
        <property type="gene ID" value="BPSL0284"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0284"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1420"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIKEEEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="20466" checksum="BD027161A73CD835" modified="2004-10-25" version="1">MQSRFEPGGGDARGVSVADLFAGFLGLGLISFGGALPFARRALVEERRWLSADEFTDLLGLCQFLPGGNVINLSVAVGMRFRGVPGAIAGLLGLVAGPTLVVIALGVLYAKTQQNPAVHHLFGGLAAAAAGLLIAMAVKVAKPLRHMRAGACVAVLAFVAIAVLRVPLLPTMLVVTPVSIWLASRAPRGANAGAQGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YF1</accession>
    <name>Q63YF1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106864.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0236"/>
    <dbReference type="EnsemblBacteria" id="CAH34224">
        <property type="protein sequence ID" value="CAH34224"/>
        <property type="gene ID" value="BPSL0236"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0236"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.252"/>
    <dbReference type="eggNOG" id="COG3295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWVLLMD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032307">
        <property type="entry name" value="PepSY_TM-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40115">
        <property type="entry name" value="PTHR40115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16357">
        <property type="entry name" value="PepSY_TM_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="27199" checksum="B4FB5FBBE4EB881F" modified="2004-10-25" version="1">MFCANGSRSVNAPESIEKHSGVVVPYPGSPRKLDAFELAERRRRSRRATFIKWLRKVHGWVGLWGAALGLLFGVTGVLLNHRAPPLKISSGEPQVSQLQLALPSPAPATPHAMAAWIRRELAFDGRLGRVRKEPAQPVAWGGRRVEQPEHWQFGLFGPRSNVQVEYWKGNGYVSVKRTDNAFLTALNNLHRGVGMNLFWVLLMDTIAGSMVLLSLTGVLLWTELNKRRTVGVVLVAGSVAAALAAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YL3</accession>
    <name>Q63YL3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202809.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106802.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0174"/>
    <dbReference type="EnsemblBacteria" id="CAH34161">
        <property type="protein sequence ID" value="CAH34161"/>
        <property type="gene ID" value="BPSL0174"/>
    </dbReference>
    <dbReference type="GeneID" id="56594113"/>
    <dbReference type="GeneID" id="66547164"/>
    <dbReference type="KEGG" id="bps:BPSL0174"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1548"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAHPRYE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="118" mass="12585" checksum="3238F5276A21308E" modified="2004-10-25" version="1">MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIMKVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS3</accession>
    <name>Q63YS3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189208.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106742.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0115"/>
    <dbReference type="EnsemblBacteria" id="CAH34101">
        <property type="protein sequence ID" value="CAH34101"/>
        <property type="gene ID" value="BPSL0115"/>
    </dbReference>
    <dbReference type="GeneID" id="56596716"/>
    <dbReference type="KEGG" id="bps:BPSL0115"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1609"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYWGNLL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="289" mass="32419" checksum="4EB8268A91462385" modified="2004-10-25" version="1">MFDQVVFAGGGNRCWWQAGFWDVVRPALDLRPRVIAGISAGAATACMLYTRDSRWVMRYYEEALRHNRRNVHWGNLLRAEPVFPHYRIYRQALLDIYGEPFAKLAGAPDIRIGVSHVPRWLGARSAVAAGLIAYNIEKYVRKTLHPTLGRSLGFRPEFVRAQDCARVDELADLVLQSSCTPPFTPVLRRDGRPVLDGGMVDNVPVGALDASPGAVLVMVTRRYPRPQTFVVDGGGQRRLYVQPSSKVPISSWDYTSPHQMQHAYDLGRRDGERFVGAMPQCLDEDGAVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YW5</accession>
    <name>DNAA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaA</name>
        <name type="ordered locus">BPSL0075</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106700.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YW5"/>
    <dbReference type="SMR" id="Q63YW5"/>
    <dbReference type="STRING" id="272560.BPSL0075"/>
    <dbReference type="EnsemblBacteria" id="CAH34058">
        <property type="protein sequence ID" value="CAH34058"/>
        <property type="gene ID" value="BPSL0075"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0075"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1660"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114151" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="238"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="533" mass="58352" checksum="AC277CE737A21B6D" modified="2004-10-25" version="1">MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDAAANTLSIAAPNRFKLDWVKSQFSGRISDLARDFWNAPIEVQFVLDPKAGQRSPAGATPLAPRAPLPSANPAPVAPGPASAPAVDAHAPAPAGMNAATAAAVAAAQAAQAAQANAAALNADEAADLDLPSLTAHEAAAGRRTWRPGAANANSEAADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIHAIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQEEFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVSLSEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV4</accession>
    <name>Q63HV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190769.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112318.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2316"/>
    <dbReference type="EnsemblBacteria" id="CAH39802">
        <property type="protein sequence ID" value="CAH39802"/>
        <property type="gene ID" value="BPSS2316"/>
    </dbReference>
    <dbReference type="GeneID" id="56598427"/>
    <dbReference type="KEGG" id="bps:BPSS2316"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5949"/>
    <dbReference type="eggNOG" id="COG2854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MMGAWLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008869">
        <property type="entry name" value="MlaC/ttg2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36573">
        <property type="entry name" value="PTHR36573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05494">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266053" evidence="1">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="198" mass="21244" checksum="91B3E85F9969E0F3" modified="2004-10-25" version="1">MKRHLFAFVAAAVVSVSAFAQTAPVEVVKNAVEGTVGAMKADPAARGGDMAKITQIVEARFLPATNFERTTRIAVGDAWKQASPQQQQELYKQFRILMTRTYAASLAQLGSQDAKFTFKAAGAGGADALVRSTVTTPGDSQSVGYRLGKIGNDWKIYDIDMSGAWLIQVYQGQFKAQLAQGGIDGLIAFLTKHNARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IB5</accession>
    <name>Q63IB5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555808.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112157.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2156"/>
    <dbReference type="EnsemblBacteria" id="CAH39640">
        <property type="protein sequence ID" value="CAH39640"/>
        <property type="gene ID" value="BPSS2156"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2156"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5728"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DVIAMPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="36828" checksum="D0227BC9138F249C" modified="2004-10-25" version="1">MERRWKRRPAGANWGEFGDDDQKGRLNWLTERKVLEGMAEVKAGKVFSLSLPLDVPRGGGLNARRQPPRVMAAQAGGRPYFGYRADESARNATDVVCDDAFCVHSQYSTQWDALSHVGGVFDADDDGRAEVVFYNGYRLGEHVLVPKEGDSVGGAHALGIEVMAQTGVQGRGVLIDLRHHYGDARRKVGYEALMRVLDADRVEVERGDMVCVHTGFAERLLGEEAGALTGGCVLDGEDERLLRWVDESGLSVLAADNHAVEERPGVLKARERPGALMPLHELCLFKLGIHLGELWRLTPLAQWLREKGRSRFLLTAPPLHIRGLVGSPVNPVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC8</accession>
    <name>Q63IC8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative POT-family proton dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523420.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112144.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39626">
        <property type="protein sequence ID" value="CAH39626"/>
        <property type="gene ID" value="BPSS2143"/>
    </dbReference>
    <dbReference type="GeneID" id="56531760"/>
    <dbReference type="KEGG" id="bps:BPSS2143"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5712"/>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMMGVWF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="500" mass="54291" checksum="F295BD6EE5D517FF" modified="2004-10-25" version="1">MNTRVSQTRSFTTVFLIEMWERFGYYGMAALLVLFMVDKLGFTDGQANLTWGAFTALVYASPSIGGWIGDKVLGARRSMIIGAVVLCAGYLMLAIPNDQLAFMYTSLGVIVVGNGLFKSNAANLVRRIYEGDNARIDSAFTIYYMAVNIGSTASMLATPWIKDHWGWHTAFAVCCAGMALGILNFVLMHRTLAHIGSQPDAQPVHWRRLAAVAAGGVALGLATMYVLGHKQLAVASVWVAAFAILAIFAYMIAKSNRAERSGLIAALLLIAQVILFFIFYVQMQTSLTLFALRNVDPRFMLFGTTLFTWSPAQFQALNPIWIMLLSPVLVAIYNGLGKRGRDLPVAGKYALGFGVVALGYLAFSISGRFAVDGRVSSWFMVAGYGFYSLGELLVSGLGLAMIARYVPARMGGFMMGAYFVATGVSQYLGSVVANFAQMPSNDLPATASLPLYIELFTGLGWLAAAGMAIGLLMLPLMNKLSREHHRCEAQRRETQALAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63II1</accession>
    <name>Q63II1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112091.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2091"/>
    <dbReference type="EnsemblBacteria" id="CAH39571">
        <property type="protein sequence ID" value="CAH39571"/>
        <property type="gene ID" value="BPSS2091"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2091"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6479"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="29382" checksum="F687E9410C263E12" modified="2004-10-25" version="1">MLVQTLPDVSAVRTEFDLDHRPVCMTLIGGRQWGYEWDTFGNLLAQSDPSGAISRYTYDEYGQLVEHTGPRGASTRFDYHPDGNLAAQIDALGHRTQYRYDARGYLVEAIDALGQQTQYEYDRNGHLTRAIEPGGREIHCAYDADGNLSRHRDPMGHVTQMEYSALGQVSRRLAPDGTTVEYRYDSHITSAGFRTRPIGRLPMFACQTCRRYFSRTAAPHSARNISRNSIYSCPCCRIRSRALMRANRWAAYRPTSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW4</accession>
    <name>Q63IW4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpC</name>
        <name evidence="11" type="ordered locus">BPSS1952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188221.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111958.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1952"/>
    <dbReference type="EnsemblBacteria" id="CAH39430">
        <property type="protein sequence ID" value="CAH39430"/>
        <property type="gene ID" value="BPSS1952"/>
    </dbReference>
    <dbReference type="GeneID" id="56596855"/>
    <dbReference type="KEGG" id="bps:BPSS1952"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5442"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPHRLDC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024037">
        <property type="entry name" value="Alt_ATP_synth_F1_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03166">
        <property type="entry name" value="alt_F1F0_F1_eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16466" checksum="E3C73DC7570FBB61" modified="2004-10-25" version="1">MGAELRVTIATPARVCVDDLPIVSLRAEDASGAFGIRAGHVDFVTLLRASVVRWRTADGATHYAALDGGVLRVTRGARIEIACRDAVLGESLAELEAVVRGVRATQLDEKRRARVDETRLHAQAVRRLLTYLRPEHAKDGVHAPLKPETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW6</accession>
    <name>Q63IW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111956.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1950"/>
    <dbReference type="EnsemblBacteria" id="CAH39428">
        <property type="protein sequence ID" value="CAH39428"/>
        <property type="gene ID" value="BPSS1950"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1950"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6311"/>
    <dbReference type="eggNOG" id="ENOG5033A7U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTIAIRC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017581">
        <property type="entry name" value="AtpR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12966">
        <property type="entry name" value="AtpR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03165">
        <property type="entry name" value="F1F0_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="99" mass="9991" checksum="AA0AA43795551E26" modified="2004-10-25" version="1">MWETARASFDGIAAAIGLALGFAAGACHFVSLGWNSRLFVAGRAGVALALQFARVALAVAVLVVLARAGFGMLVAGSAGFFAARAIAVRRAAALTGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX1</accession>
    <name>Q63IX1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
            <ecNumber evidence="9">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="9" type="ordered locus">BPSS1945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="9"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009972311.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111951.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1945"/>
    <dbReference type="EnsemblBacteria" id="CAH39423">
        <property type="protein sequence ID" value="CAH39423"/>
        <property type="gene ID" value="BPSS1945"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1945"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5435"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYYRTVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="29691" checksum="39A6F5F9B9DA8A38" modified="2004-10-25" version="1">MSDKLAAIEARTDTARQLQTVIGAMQGVAAARAHEAQQRLPGIRASAATVGAAIGDALSAGARSGETAAGARAAPRARLVVVLCSEQGFVGAYNAQLIEHATRPGPSVSREYMMVGSRGAMLADAGGVPLVWRTPMAARADDVVHLANRITDALYAHLAKRGAQPVSIVHAMPGGAARLEVTERRLLPFDYARFDTAPRAQPPLVHLPPATLLAELAQAYVFVELCEAAMLAFAAENEARTRAMIAARESVERALGDLLQAYRIARQDEITADIVELAASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IZ2</accession>
    <name>Q63IZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187971.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111930.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1924"/>
    <dbReference type="DNASU" id="3096350"/>
    <dbReference type="EnsemblBacteria" id="CAH39402">
        <property type="protein sequence ID" value="CAH39402"/>
        <property type="gene ID" value="BPSS1924"/>
    </dbReference>
    <dbReference type="GeneID" id="56596884"/>
    <dbReference type="KEGG" id="bps:BPSS1924"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5408"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEWDAFV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="149"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="216" mass="23168" checksum="773183E2651D3D92" modified="2004-10-25" version="1">MKTDRQIKQEVEDELTGDPMIDVAHFDVDVAGHIVTLTGHPSSYAEKLAAEKAANRVAGVRAVVVDVQVRLPSDDVRTDEAIADAVRSTLHWTVGLHDAAVHVQVEAGWVTLSGQVDWPYQSHVAARAISQMRGVTGVTNQIEVLGDISADEIAGGIRRAMQRHAEREANHIDVTVKDGTVTLAGKVGSYAERAVARGAAWSARGVRAVVDDLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J10</accession>
    <name>Q63J10_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cis-1,2-dihydroxycyclohexa-3, 5-diene-1-carboxylate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">benD</name>
        <name evidence="3" type="ordered locus">BPSS1906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525022.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111912.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1906"/>
    <dbReference type="EnsemblBacteria" id="CAH39384">
        <property type="protein sequence ID" value="CAH39384"/>
        <property type="gene ID" value="BPSS1906"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1906"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5375"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VWDTTMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="27380" checksum="A67378134F3CE497" modified="2004-10-25" version="1">MNTHHAPGRFSGKVTIVTGAAQGIGRGVARRAAREGATAVLVDRADLVHEAAADIVAAGGRALAVVADLETYAGAEAMARAAVDAFGSIDVLVNNVGGTIWTRPFDRYEAAQIEAEIRRSLFPTLWCCRAVLPGMIARGGGAIVNVSSIATRSVHRVPYAAAKGGVNALTASLAFEHAAHGVRVNAVAAGGTDAPPRKVPRNTEPQGDDDARWYRAIVDQTLSSSLMHRYGTIDEQVAAILFLASDEASYITGSVLPVGGGDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JC6</accession>
    <name>Q63JC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552037.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111796.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1792"/>
    <dbReference type="EnsemblBacteria" id="CAH39268">
        <property type="protein sequence ID" value="CAH39268"/>
        <property type="gene ID" value="BPSS1792"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1792"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5233"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EIVMFAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="291" mass="30824" checksum="E55ED8AAB7A30126" modified="2004-10-25" version="1">MKPLDLDAVRAFVLVAELASFTRAADALGTTQSAVSLKLKRLEAQLGKPLLERTPRRVTLAAVGAAFLPAARELLDAHERALAALSSAQRRLVIGVSEHVAVPDLPAVLTGLNRHDPGLTLEMHVGMSAGLLAQYDERRLDAAFVRHEPGEDPPRDDATLLFTEPLAWLAAPGWTPRADEPLPLAVLAGPCGVRAAALRALERAGVRWRERFTGGGVAAVAAAAAAGLAVCPLARRVAPRSLVDVGARLRLPALPDSQVALYSRVRDARSIDTLRRFADSLAGPAQSAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JF3</accession>
    <name>Q63JF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranyltranstransferase</fullName>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispA</name>
        <name evidence="3" type="ordered locus">BPSS1763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525142.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111769.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1763"/>
    <dbReference type="EnsemblBacteria" id="CAH39238">
        <property type="protein sequence ID" value="CAH39238"/>
        <property type="gene ID" value="BPSS1763"/>
    </dbReference>
    <dbReference type="GeneID" id="56529822"/>
    <dbReference type="KEGG" id="bps:BPSS1763"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5194"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="30650" checksum="DAA8DD37B77353D2" modified="2004-10-25" version="1">MTFDQWMRSVLERVETALGHYLPAGTVAPAQLHEAMRYAVLGGGKRVRPLLCHAAGELTGASEAARDAASAALEMIHVYSLVHDDMPCMDDDALRRGKPTVHVKYDEPTALLVGDALQSQAFVALTDAAALPADRQAALVRELALASGSIGMAGGQAIDLASVGVALTRDALETMHRMKTGALLRASVRMGALAGETPSGDAMRALDAYAAAVGLAFQVVDDILDVTTDSATLGKTAGKDAANDKPTYVSIIGLDASRALAAQLRADAHAALEPFGARAQRLAELADLVVNRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JG3</accession>
    <name>Q63JG3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111759.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1753"/>
    <dbReference type="DNASU" id="3096059"/>
    <dbReference type="EnsemblBacteria" id="CAH39228">
        <property type="protein sequence ID" value="CAH39228"/>
        <property type="gene ID" value="BPSS1753"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1753"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6068"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CANEYIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="286" mass="32439" checksum="0DA4ED2003A91E8D" modified="2004-10-25" version="1">MREEWLFSRYLNRKRVQRAASLGAGRAETEIALLELGAVEHFDLFDVSSVGIEYAKSIAEEKGFGHKVTCHVGPIGCAELNENTYDLITFVASLHHMEPLAETLERANRALTQHGIIWCANEYIGPDRFDYPVAHAAIAKSFFQQIPPGLRNHWHRELQFPTPQEVAEVDPTEAPCSSKIEPTMRDMFPALEIMPLYGAFAFMVFWGLNHDALYETPEGTELTRFILGMDKALTDAGILPTYFAHIIARKNNAPRQQIHRPGRHSSALLYRYAQRAASILRHLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JN0</accession>
    <name>Q63JN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187228.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111692.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1687"/>
    <dbReference type="EnsemblBacteria" id="CAH39160">
        <property type="protein sequence ID" value="CAH39160"/>
        <property type="gene ID" value="BPSS1687"/>
    </dbReference>
    <dbReference type="GeneID" id="56598042"/>
    <dbReference type="KEGG" id="bps:BPSS1687"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5099"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPGHSWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="352" mass="39040" checksum="A4534A40C56B2393" modified="2004-10-25" version="1">MTRDTFVAPPAHTGRIVQLDGLRAFAVLAVFFQHALKAPLWIGVDLFFVLSGLLITGILLERKARGESYFGYFYARRVRRIVPPYLLLLVVSSILFGVEWARHWPWYAFFSTNIGLSLGGIGHESLNVLWSLAVEEQFYIFWPFVVLLVPERALARVAAALIVAAPLLRAIATPWFDSFWPIYYLTPFRMDLLAAGALLAVALRRDRRALEPYYGAAIAAACAALAVLAWLHLSFPRFRAANTPLSNATLYSVSLVLCTSIVVIALRGRGLAQRVLTHPALVYVGTVSYTIYLIHLSVLYALWPLHPNRYLTAALAFGVTLAYASASWYGFERRLTRGAPRQALAGAARASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JS3</accession>
    <name>Q63JS3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203217.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111649.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1643"/>
    <dbReference type="EnsemblBacteria" id="CAH39117">
        <property type="protein sequence ID" value="CAH39117"/>
        <property type="gene ID" value="BPSS1643"/>
    </dbReference>
    <dbReference type="GeneID" id="56597994"/>
    <dbReference type="KEGG" id="bps:BPSS1643"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5035"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDSMRIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="306" mass="34053" checksum="F80BEF578C95DC10" modified="2004-10-25" version="1">MVSLDRFDVFRAVVEAGSFTGAANVLNQARAAVSFHVKQLEAELGVTLLTRTTRRVELTEAGERFYERCLRVLAEAEEAIDDARAEHGGMQGSLRVTSTVEYALRIVAPALSEFMSAHPALRVRLETHTSQADLVRDRFDVAIRLGRLEQFRDLPYRGVCIDTYDVRPVASPALLAAHGVARIDSPEALARLPQLGHSRLSQVASWLLHDRDGREHVYRPAAKPHLIADNASVLRAFAQQGGGVALLPEWLVRDDLASGTLIDALPGYRFAQQGVYALYPSARHVPQKIRAWIDFIKRYVRRRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT5</accession>
    <name>Q63JT5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940890.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111637.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1629"/>
    <dbReference type="EnsemblBacteria" id="CAH39104">
        <property type="protein sequence ID" value="CAH39104"/>
        <property type="gene ID" value="BPSS1629"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1629"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5015"/>
    <dbReference type="eggNOG" id="COG4791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IPFWAAE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006304">
        <property type="entry name" value="T3SS_SpaR/YscT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01401">
        <property type="entry name" value="fliR_like_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="34849" checksum="FF7D7BA74E142027" modified="2004-10-25" version="1">MTTYDIFALQHLGDEFIRFIVLLALSSERLLVLMAILPATADNVMKGPMRSGAAAVWCLFVAGGQQALIPQLHGAFLMIACVKEAVIGLVLGIAASTVFWAAEAIGTYLDDVAGFNNVQMQNPSSGAQTSLMATLFGQLTIASFWLLGGMTFLLGALYESFAWWPLGSFDPVPAPLLEMFAQARIDMLMNMIARIATPMMAMLLLVDLGLAFVARSAQKLDLMSVSQPLKGAIAVLIVAVLAGNFVSEMRGQISLSGLAQQIGRLARQPAGGVSGVSGVSGVSGVSGVSGVSGVSGVSGASGASGASGASGASGASGASGASGASGTSSTSSTWDATSVTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JV1</accession>
    <name>Q63JV1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201197.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111621.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1613"/>
    <dbReference type="EnsemblBacteria" id="CAH39088">
        <property type="protein sequence ID" value="CAH39088"/>
        <property type="gene ID" value="BPSS1613"/>
    </dbReference>
    <dbReference type="GeneID" id="56597965"/>
    <dbReference type="KEGG" id="bps:BPSS1613"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4999"/>
    <dbReference type="eggNOG" id="ENOG50302VM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFEDCAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="8650" checksum="9CE66D2E6D341FEE" modified="2004-10-25" version="1">MYEALERVAGEVGSLEQALAAPDAAARIGAIRRALGETAERVSAATAHAASDYDRDAMQKIYRGLLAAQRIVATLHEANAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW5</accession>
    <name>Q63JW5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type IV pilus biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilO</name>
        <name evidence="2" type="ordered locus">BPSS1599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e94981" last="e94981">
            <title>Redefining the PF06864 Pfam family based on Burkholderia pseudomallei PilO2(Bp) S-SAD crystal structure.</title>
            <authorList>
                <person name="Lassaux P."/>
                <person name="Conchillo-Sole O."/>
                <person name="Manjasetty B.A."/>
                <person name="Yero D."/>
                <person name="Perletti L."/>
                <person name="Belrhali H."/>
                <person name="Daura X."/>
                <person name="Gourlay L.J."/>
                <person name="Bolognesi M."/>
            </authorList>
            <dbReference type="PubMed" id="24728008"/>
            <dbReference type="DOI" id="10.1371/JOURNAL.PONE.0094981"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 1-192</scope>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187526.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111607.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="4BYZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.55 A"/>
        <property type="chains" value="A=1-192"/>
    </dbReference>
    <dbReference type="PDB" id="4BZ0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.76 A"/>
        <property type="chains" value="A=1-192"/>
    </dbReference>
    <dbReference type="PDBsum" id="4BYZ"/>
    <dbReference type="PDBsum" id="4BZ0"/>
    <dbReference type="SMR" id="Q63JW5"/>
    <dbReference type="STRING" id="272560.BPSS1599"/>
    <dbReference type="EnsemblBacteria" id="CAH39074">
        <property type="protein sequence ID" value="CAH39074"/>
        <property type="gene ID" value="BPSS1599"/>
    </dbReference>
    <dbReference type="GeneID" id="56597951"/>
    <dbReference type="KEGG" id="bps:BPSS1599"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4980"/>
    <dbReference type="eggNOG" id="ENOG502Z9DZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYIAVRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009663">
        <property type="entry name" value="PAP_PilO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06864">
        <property type="entry name" value="PAP_PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4BYZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4BZ0"/>
        </source>
    </evidence>
    <sequence length="432" mass="47871" checksum="3B54C9B51CAAF88A" modified="2004-10-25" version="1">MSAQVIQIGRQRFVGGLFWQSLSRRNELRAEAVELAKKLKFDLMVLRIDRGVAAAGYANTRDGFAPGHLSLGAMVSRAIALEGAFYNGRRQPAPNWLGAFALPDGRWAYFAVRDHAFMPNGDWVGSREEALERLHTDYAWGGWNVVIGEPELERQGFQNFQPKRLDDLLPRRGGRPRTERWWALRPVERRLSPRAALIAATAACVVLGGAFAYWHHRAKVEAEEREAALERVRAELAARQARSGPVAPPWAALPDALAFARACAMRFGRLAPGGWRLERYECTPGTAHYAWARNGSNVRYLLVVEPGATLDTDGERATLDVPLTAPTANDTPLADDSVVRTQLLARLQWLDAAAKLERLLPEQGPRAPLANLAQQAAALPASPTWRAYRLNANLGGIAPPEFVRAIDVPGLRVERIAYQNNQWTLEGVLYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JY2</accession>
    <name>Q63JY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS1582a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111590.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1582a"/>
    <dbReference type="EnsemblBacteria" id="CAH39057">
        <property type="protein sequence ID" value="CAH39057"/>
        <property type="gene ID" value="BPSS1582a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1582a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4959"/>
    <dbReference type="OMA" id="PRRAMAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="196" mass="21925" checksum="B6F5CF371294FF9B" modified="2004-10-25" version="1">MPVDRSRPAARARKSPPPARRPAGTFLPSAPCERGARAPANAPERHRRLAVFRSDDFDREPRRAMAHAGIRFARRCGGHPVAPPPDMVRRRSIRARRGPCAGAATKPERSRSSDCQKAADYTGHDGREAHGTAQFLAEKRLPRVGRNRGETGARRPFPMRKRIIPHTQTLPPRSAHRRARFQRRQAPRAATKRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K18</accession>
    <name>Q63K18_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2006" name="J. Mol. Biol." volume="359" first="322" last="330">
            <title>Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Zhang L."/>
                <person name="Wang Y."/>
                <person name="Picking W.L."/>
                <person name="Picking W.D."/>
                <person name="De Guzman R.N."/>
            </authorList>
            <dbReference type="PubMed" id="16631790"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2006.03.028"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 1-84</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MxiH/PrgI/YscF family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528826.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111554.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="2G0U">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-84"/>
    </dbReference>
    <dbReference type="PDBsum" id="2G0U"/>
    <dbReference type="SMR" id="Q63K18"/>
    <dbReference type="STRING" id="272560.BPSS1548"/>
    <dbReference type="EnsemblBacteria" id="CAH39021">
        <property type="protein sequence ID" value="CAH39021"/>
        <property type="gene ID" value="BPSS1548"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1548"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4905"/>
    <dbReference type="eggNOG" id="ENOG5032ZZJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PNKDWTL"/>
    <dbReference type="EvolutionaryTrace" id="Q63K18"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="DisProt" id="DP00956"/>
    <dbReference type="InterPro" id="IPR021123">
        <property type="entry name" value="T3SS_needle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037203">
        <property type="entry name" value="T3SS_needle-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011841">
        <property type="entry name" value="T3SS_needle_YscF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09392">
        <property type="entry name" value="T3SS_needle_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140129">
        <property type="entry name" value="SSF140129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02105">
        <property type="entry name" value="III_needle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2G0U"/>
        </source>
    </evidence>
    <sequence length="89" mass="9894" checksum="613FC2D20BE3352A" modified="2004-10-25" version="1">MSNPPTPLLADYEWSGYLTGIGRAFDDGVKDLNKQLQDAQANLTKNPSDPTALANYQMIMSEYNLYRNAQSSAVKSMKDIDSSIVSNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KC7</accession>
    <name>Q63KC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sodium bile acid symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266245.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111445.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1433"/>
    <dbReference type="EnsemblBacteria" id="CAH38908">
        <property type="protein sequence ID" value="CAH38908"/>
        <property type="gene ID" value="BPSS1433"/>
    </dbReference>
    <dbReference type="GeneID" id="56530147"/>
    <dbReference type="KEGG" id="bps:BPSS1433"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4761"/>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTAMVLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="38463" checksum="002F003197A16940" modified="2004-10-25" version="1">MNPSNVAPPENAAAQPAINFFERYLTVWVALCIVAGIALGQARPDLFRQIGRMEYAQVNLPVGLLIWVMIIPMLVKVDFGALHEVRRHVKGIGVTLVVNWLVKPFSMAFLGWLFIKQFFAPMLPAAQLDSYLAGLILLAAAPCTAMVFVWSRLTGGDPLFTLSQVALNDSIMVIAFAPLVGLLLGMSAITVPWATLLTSVVLYIVIPVILAQLWRKRLLANGQAALDAAMAKIGPWSIAALLATLVLLFAFQGEAILAQPLVIALLAVPILIQVFFNSALAYWLNRAVGEKHDIACPSALIGASNFFELAVAAAISLFGFHSGAALATVVGVLIEVPVMLLVVRIVNRTKGWYERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KF8</accession>
    <name>Q63KF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1402"/>
    <dbReference type="EnsemblBacteria" id="CAH38877">
        <property type="protein sequence ID" value="CAH38877"/>
        <property type="gene ID" value="BPSS1402"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1402"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5635"/>
    <dbReference type="eggNOG" id="ENOG5033AF7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAIDHIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013390">
        <property type="entry name" value="T3SS_HpaP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09483">
        <property type="entry name" value="HpaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02557">
        <property type="entry name" value="HpaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="228" mass="24864" checksum="87CC294327EBDA87" modified="2004-10-25" version="1">MMTTVAHIGSRPLRIIPGSTPAAPDETRQRRFDYASLVRAQARRGPVTRSAPPPPPGSEGGWALAPPSESCDEAAPAAGNTTRAPSTPFDEPLDGNPVVAPPTCPIDAHESFGRVRHAIAPVVSVIVERQSHFTRIVGMLAREIGAFCSDGAIVCAGNWEAQLTLDPELLPRTTLHVALSRFIIRIRFDVPDGETRDLLLTHRSLLERELDEVMRCWGEARDIQLSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KK4</accession>
    <name>Q63KK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sensor kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545843.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111368.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1358"/>
    <dbReference type="EnsemblBacteria" id="CAH38829">
        <property type="protein sequence ID" value="CAH38829"/>
        <property type="gene ID" value="BPSS1358"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1358"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4664"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWEGRIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="292"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="492" mass="55114" checksum="FC88E0AEBDC41697" modified="2004-10-25" version="1">MSSPSKNVEILLVEDSVTDALLIGEALIDVTEFAPHVVNAELLSAALECTKRAHFDVVLLDLGLPDAHGLDTFRQFHRQVPDVPVLVLTGLDDLSVGLQAIQEGAQDYLLKKRVETPLLSRAIRYAMERHRVAAALAASEERFQLAVSGASAGLWDWNPKTGAMYLSPHFKKIMGYEDHELPDEITGHRESIHPDDLKRVLDALKAHLEHRDTYDVEYRVRTRSGDYRWIQSRGQALWNSAGEPYRMVGWIMDVTDRKRDEDALRVSREELRRLSAHIQSIREEEKTRIARELHDDLGQQLTALKMAVTLVDNELKDAGWASRTSRLPNVYALIGQLLDTVRRIAADLRPVMLDDLGLMAAIEWLTHEFVERYRIPVTSRIEADDIAFTRGSATEVFRIVQEALTNVARHSEATEVTLDIIRDEPNCIVRIADNGCGTARDTRPNRHSLGLLGMRERAARLGGEIRIDTAPGRGFALTATLPLAVIEAADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KL4</accession>
    <name>Q63KL4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative HlyD family efflux pump protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186853.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111357.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1347"/>
    <dbReference type="EnsemblBacteria" id="CAH38818">
        <property type="protein sequence ID" value="CAH38818"/>
        <property type="gene ID" value="BPSS1347"/>
    </dbReference>
    <dbReference type="GeneID" id="56597550"/>
    <dbReference type="KEGG" id="bps:BPSS1347"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5565"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYSDSHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="6">
        <location>
            <begin position="87"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="417" mass="44112" checksum="CABEBA43EE64390C" modified="2004-10-25" version="1">MNDTATDTARAKAPTDPAVSDGAPASGHGLPASPETAATLAARRATRRRRFAWFFGVLAIVALGAALYWFIVGRFSEETDDAYVAGNVVQIAAQIQGTVTDVLVADTQQVKAGQALVRLDDAEAAAAFAQAQAQLAQAVRQVANTRLSMQTYEQTVKAREADLKLAQQAYRARAGASVEVVAPEELARAKSSLANAQAALAGAQAQREAARALGSERPVGQNPAVQQAAAQFKLAYRNLKRTTIVSPVDGTVGQRSVQIGQQVGPGVPLMSVVQLRQVWVEANFKEGQLRHMRVGQPVRLESDLYGARVTYHGRVEGFSAGTGSAFSMLPSQNAAGNWIKVVQRLPVVISLEPSELAAHPLRVGLSMRATVQTKARGGHLLDGDAPLPAQRTRVHEMHAGEAEAAAEAVIRANDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ2</accession>
    <name>Q63KQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative BCCT (Betaine/carnitine/choline) family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551775.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111319.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1310"/>
    <dbReference type="EnsemblBacteria" id="CAH38780">
        <property type="protein sequence ID" value="CAH38780"/>
        <property type="gene ID" value="BPSS1310"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1310"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4601"/>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHAWAIY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="676" mass="73433" checksum="B5F065958DDCC00A" modified="2004-10-25" version="1">MPPSRSTPRTTLKPPVVVPSLAVIGALLAVCALRPNEAGALFGAAQQWIVERFDWFYVLAITTFLIFLVLIAASRFGNIKLGPDDAEPEFSFVSWTAMLFAAGMGIGLMYFGVGEPIQHYLSPPTAAGGTPAAAREAMLMSFFHWGLHAWATYGVMGLVLAYFGFRYNLPLTLRSGLYPVLREGVNGWIGHTVDAFALVGTVAGIAVTLGYGVLQLSAGLHTIAGWQTDTDTFRIGLVAVVVALAGLSAASGLDKGVRRLSELNLMLAFALLAFVVVAGPTSFLLRAIGDNIGEYLSKLVSLSFRTYAYEAPNDKGWFGGWTLLYWAWWVSWSPFVGMFIARISRGRTIRQFVIGVLLVPTAFNLVWMTAFGNSAIWLDTHAAAGALAQTATNVDALLFRFFDYLPLTQLLSVAAIVLIAVFFVTSADSGAFVIDAIATRGAPQSPVWQRLFWAAVLGVTASVLLVAGGLKALQALTLVAALPVALVMLALCYGLWRGLKADHAHYSQDMAPATSFWTGQHWRHRLSQILRHTSDADAQQFIAQTVEPALRKVADELKAGGVDAHVARDDDDAVRLTVPAPAQRDFVYGARVSRKSAPAFRIREAAEPEPQREHVCEVLTFFADGRLGYDIEYLRGDEIIADVLRQYERYVSLAADTRTHLLNRAPEHAGPDGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS3</accession>
    <name>Q63KS3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553450.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111298.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1289"/>
    <dbReference type="EnsemblBacteria" id="CAH38759">
        <property type="protein sequence ID" value="CAH38759"/>
        <property type="gene ID" value="BPSS1289"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1289"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4570"/>
    <dbReference type="eggNOG" id="COG1988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FACGGLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="18740" checksum="FF38DC052A7A38D7" modified="2004-10-25" version="1">MASHAAHHASGWAAGLVAAALVAQAGAAGPWHVYSLAAFAAGVAGGTAPDWLEIAWWRRTRRLWVTHRTITHWGVGWAALLAFAYRSLSHRHPWAAPLFGFACGGLVHLIADWPNPLGVPWLWKRHSLNWWNSGHCDLIVVAAAWAGALWLAQAAWGHAAPLAHWLGWLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LJ5</accession>
    <name>Q63LJ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111026.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1020"/>
    <dbReference type="EnsemblBacteria" id="CAH38481">
        <property type="protein sequence ID" value="CAH38481"/>
        <property type="gene ID" value="BPSS1020"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1020"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5149"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRHEYFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="198"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="38036" checksum="CC2568F49C00C21A" modified="2004-10-25" version="1">MPSPVKPRTYAMPERSDRLDFYIRDEAARRAITEPHRHAYFQIQFNLGGDTEQRIGGFTRAFPRGALAFVLPYREHLIAHPPGAHFVVINFSQTFLRADLDVDPLDLEDVCAQRAPELAPFRFQEHLDFILTGAAFDDARRLAQRMLEANRARTFGSVPLLRGYLLQLIGLVCTQYAGPLTKLAQSGAHRTGRRDAFARVLRHVRANLTNDALTLAGTARAACLSPNYLAHLIRKETGSTFTDLVTARRIALAQSLLAHTTRRIADIAHAVGFRDEGYFSRRFRACVGVSPKEYRDANGAPGPADALDSADALDSVDTAGPRAAPGGGETRGAAGAKSPARAAAKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LK0</accession>
    <name>Q63LK0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198340.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111021.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1015"/>
    <dbReference type="EnsemblBacteria" id="CAH38476">
        <property type="protein sequence ID" value="CAH38476"/>
        <property type="gene ID" value="BPSS1015"/>
    </dbReference>
    <dbReference type="GeneID" id="56597387"/>
    <dbReference type="KEGG" id="bps:BPSS1015"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4195"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KHRYITH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="35491" checksum="E5CF36496554A142" modified="2004-10-25" version="1">MDMLDNMRLFVRVVEAGSFTAVAKEIDATTAQVSRAVSNLEAHVQTRLLHRTTRHLGLTESGQRYFERAKSILAEIDYANAEARNALLRPSGKLRIHAMTGLGQSHVVSSIVRYQEDNPDVSVELTLAQRMPNLVEEGYDVSIVSASHLPDSGYVAQTCGTSCSVLVASREYLARHGTPTTPDDLAKHVCLRLDTPASPGGEWRLERDDGDETVYALPPAPFQANVPDALSVAVRAGRGIGSIALYTALDDIREGRLVRVLPNYRLDTLSVYAVYATRRYLDAKIRTFLDHLRTTLAPALENDLKELNRLNGGVGKKALREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LQ3</accession>
    <name>Q63LQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Rhs-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939999.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110968.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0960"/>
    <dbReference type="EnsemblBacteria" id="CAH38422">
        <property type="protein sequence ID" value="CAH38422"/>
        <property type="gene ID" value="BPSS0960"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0960"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7274"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGKGTHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03527">
        <property type="entry name" value="RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="310"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1541" mass="171948" checksum="4B90BD61FF55D336" modified="2004-10-25" version="1">MGEVQSSAPSDSQQKLAALAQRGSNADAVQTVSNMGLAINAAQVTAAGTSAWAAGTFQCFAGRVIAPLGGAMLGGALAEALGADRPVTWVLDKMGLPAVAKPGKAPARVGHKIVHENAFIGALTGLLAGIAVGVAIAAAAAAIVATGGAAAVAIAAAGPFVVGFVSGAVGGFVGAAVAKGIGHTGSVTGAIAHGSPNVSFEGAPVARVTDPVTCSKDPGMPPPQIAQGSLTVSVNGLPLARIGHKITCSAVIQEGCTTISADETTGTFGKIDANVSLLEQLVLTATDVIMMRSATKEGGLLDGVLRELLGEPIDMATGDYADYRTDFTWPHVLPLTLSRAYAGRQPVEGLLGDRWISNWSQRLRYRWPADGPATVTFFDADGQQLVYPVPHEPFNAINFWAPHYALHGSRARAVVFDERSQQSLIFEPAHAEDDVARLTRIEDRNGNTIDFEYNALGRLCTVRHSGGMTLWVTCDSRGLLQRVSEQPGGEGELVRYRFDGKRLTDVHSRFQGEFHFGYTDEGWLNHWRDSGATQVALRYDERGRVIATRTNTALYDDRFEYDDEARLTTYIDALGHRHQRWFDAQNRLIRSRDPLGRVMCASYDENGWLASRTDPLGRVSTYRHDCRGRPLQVTDAFGRVSRYGWNGAGQLVEQQDHNGKVQWHYSAEGNLVALRARSGETRFRYDARGLLVGRTDPDGAVHAWRYDGAGRPERWTDPLGRHTYLEHDRYGRLIARIDAAGHRTTYGYERGPSNPRELLASITYPDGAIARFQYDSEGLLTEAVNPLGQRTRYAWGAFDLLASVTDPGQATTRYHRDGAARLIGVTNAAGQHWKFERDPAGQLIAQTDWSGRRTRYVLNPMGQVTEKHLPDGVAIRYEYDSQDRLVALTGPRRRHVFAWTASGLLTRAEVWTRNDEAGEWRRDDRLDLEYDDACRLVEESQHGRAVGYEYDPMGRTRSMATPSGRTLWQYDAAGQLGSMESNGHRFHFDYDGLGLETLRRYTPTQAHVARHPQWVEPYSEGYAQQQDHDGRWRLTKQACATWAELRERGAARTRHYEWDAAGRCVGMHEARRGLPIAQDRWRYDARGQVVDAHYERTETRSGRERYEYDALGNVSTRQIDAGEAMTHVYHGDQLVSAGPSRYEYDARGRMIARTERRDGFRPRTWRYQWDDFDQLEQVLTPEGERWRYRYDAFGRRISKACLSTPKAGRPARIDYLWCGSRLIEAWRAYGERDGTQYEIQRWHYRPGTHSVLAQERLKYDDKPDLQNSEWFALACDPNGAPHTLYSSDGRIMWSARRELWGRVADDPDRDTVRHAVREQLRTGLLTGDAFDPPDCELRFPGQWADEESGLHYNFHRYYDPATGQYLSPDPLGLAGGLRTHAYVHDPLQWVDPLGLQGYQGSGKPEFIGNRKLPQNDLPWIKYQKRVTGRPYEETWRVGDHNVNLDGKRAGYTVEAKWTGKNSAAWESSPYNPEHEFYNESKILDQAGRLLEFNDASGGSGVRYAVSNAEAQQHFTQLFEQHFPTEMQDGTLSVWHVPGNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LR8</accession>
    <name>Q63LR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184803.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110953.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0944"/>
    <dbReference type="EnsemblBacteria" id="CAH38407">
        <property type="protein sequence ID" value="CAH38407"/>
        <property type="gene ID" value="BPSS0944"/>
    </dbReference>
    <dbReference type="GeneID" id="56597307"/>
    <dbReference type="KEGG" id="bps:BPSS0944"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7252"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVRLLCN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="303" mass="33689" checksum="DE62FB48DB31BC7C" modified="2004-10-25" version="1">MRFDLTDLRLFLHVCEAGSITGGAERAHMTLQSASERIRGMEEELGVPLLQRAKRGTRATEAGRALEHHARVVLQQIDHMRGELQQFGAGLRGHIRLLSNTAALSEYLPDALAEYLPRHPKLSVSVEERSSQEIVHAIRGKTADFGIVADSVGLDGLEQMPFREDWLIAVAAVDHSLAARERVAFAELVDADFIGMTDGSALQVHLADQAKALGKRIDYRVQLKSFDAICRLIERGVGIGIVSRHAALRAQQTMQIRLIELTDPWAHRRLTICARSFDELPKYTREFIAFLAHDPGKDESFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M26</accession>
    <name>Q63M26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266684.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110845.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0834"/>
    <dbReference type="EnsemblBacteria" id="CAH38296">
        <property type="protein sequence ID" value="CAH38296"/>
        <property type="gene ID" value="BPSS0834"/>
    </dbReference>
    <dbReference type="GeneID" id="56597158"/>
    <dbReference type="KEGG" id="bps:BPSS0834"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7110"/>
    <dbReference type="eggNOG" id="ENOG5031717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEAMIEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="78" mass="8486" checksum="6432DC4A0AC3421B" modified="2004-10-25" version="1">MTLSGNIKDGDWTVEVTTSPVQGGYVCDIEVMHGAPGGAFRHAFRHGGTYPAERDAMIEGLRAGMTWIELKMSKAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M57</accession>
    <name>Q63M57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110814.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38265">
        <property type="protein sequence ID" value="CAH38265"/>
        <property type="gene ID" value="BPSS0804"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0804"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4880"/>
    <dbReference type="OMA" id="HNPAMQT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="125" mass="13145" checksum="44B56CD758371091" modified="2004-10-25" version="1">MPLAQKGTVGELQNFAAAAFAATTGASPALVDAAHHNPAMQTLREQPMTQENVTQLCQMETDAARKGDPANWQNRLAASSVADVARHAVAQTVALNVSLGRDGPIKTQEEGGWNVHEHVIGVHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M61</accession>
    <name>Q63M61_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200889.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110810.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0800"/>
    <dbReference type="EnsemblBacteria" id="CAH38261">
        <property type="protein sequence ID" value="CAH38261"/>
        <property type="gene ID" value="BPSS0800"/>
    </dbReference>
    <dbReference type="GeneID" id="56597121"/>
    <dbReference type="KEGG" id="bps:BPSS0800"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7062"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIGPAQE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="204" mass="22975" checksum="62F1FFEA949CC13C" modified="2004-10-25" version="1">MPTLDILTRQFPGHRANLKRTILATALACFNDHGLEATTIEMIRERCDTSVGNIYHHFGNKDGLIAALFLCALEDQAQLLADYLARARTAREGVAALVHSYVDWVSAQPEFARFQFMARTAVASGPRAQELAERNRARNRRVLAWFAHAPQRDEMVQWPAELLPSLIVGQSENYCRAWLSGRVKAPPVKYRDELATAAWRSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MH0</accession>
    <name>Q63MH0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527959.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110701.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0687"/>
    <dbReference type="EnsemblBacteria" id="CAH38147">
        <property type="protein sequence ID" value="CAH38147"/>
        <property type="gene ID" value="BPSS0687"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0687"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6901"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IDNIAHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="154"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="214"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="442" mass="48882" checksum="C197D8F6A9AD3E24" modified="2004-10-25" version="1">MLRSLVRLYLVVVVCASAAILFINTSFTRFFYERISSAARETLSTYAFVLNDYLERHPGASRQPALRELAKHGNEGFGFMSIDDARKLLSAEQQRDLDRGEIAISYDGKDYFMPLVDGTVLHARPDEPPSLDIQIYAYLTVALATLLAVALWIHYHWRDLRKLEAAARAFGDGRLSTRAELSRKSNIYELSQQFNDMAERIEASIQQQREMMHGISHELKTPLARLEFGLALLSSPDAPERMRERQAALRRDVRELDELVTELLTIGRLEQGERHLALMQVMVAELIDSVAASVAHEIADRRLTLDVSVRGAPACHVCDAKLVARALLNLIRNGMRYASTTISLRASLGEAGALVLSVDDDGPGIAAADRDRVFEPFHRLDSSRDRQTGGFGLGLTIVRSVALAHGGDVRLDDTPLGGARFAITLPALEAPGREQDARGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ1</accession>
    <name>Q63MQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110620.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0599"/>
    <dbReference type="EnsemblBacteria" id="CAH38056">
        <property type="protein sequence ID" value="CAH38056"/>
        <property type="gene ID" value="BPSS0599"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0599"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4626"/>
    <dbReference type="OMA" id="HPNRPDS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="52" mass="5503" checksum="FA46BB509FBF5CA6" modified="2004-10-25" version="1">MRHPNRPDSPDVAAVSFGMLADCMATANVGAQRRFAGDALGRAGRRTARMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N05</accession>
    <name>Q63N05_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200658.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110514.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0493"/>
    <dbReference type="EnsemblBacteria" id="CAH37950">
        <property type="protein sequence ID" value="CAH37950"/>
        <property type="gene ID" value="BPSS0493"/>
    </dbReference>
    <dbReference type="GeneID" id="56597035"/>
    <dbReference type="KEGG" id="bps:BPSS0493"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6647"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MNHYMYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041029">
        <property type="entry name" value="GbpA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18416">
        <property type="entry name" value="GbpA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266999" evidence="2">
        <location>
            <begin position="32"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="3">
        <location>
            <begin position="42"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GbpA_2" evidence="4">
        <location>
            <begin position="263"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="39284" checksum="EB1D1F7F97B82951" modified="2004-10-25" version="1">MKSLFDAPSSRPRARAALTLGAAATLTASFAALLAPMNADAHGAVGFPIARQYQCRLEGGYWDPPNGSAIPHDDCRAAYRAGNNSAYPFTQWNEVSANPVGQGNDLAQLKAAVPDGLLCAGGDTSKAGLDKAPASVWRKTQLTPNNGHIELQWENTTAHNPARMRVFISKPSYDPSRPLRWDDLQQIYDAPAPAPVPANGAGHLPGSIQSFYKLDVTLPAGRTGDAVLYSYWQRIDAGNEGFFNCSDVTIAADERASGFPWVAARAFVEPGIAPRAGQQVRFRVMINDARGAEVVDVRQPITPYNAERSVWAKQIADQVNGRYGNIAKIGVRSGNTIYFDATNLDANKVWLQPNYSSALSVVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NL1</accession>
    <name>Q63NL1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188476.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110308.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37736">
        <property type="protein sequence ID" value="CAH37736"/>
        <property type="gene ID" value="BPSS0288"/>
    </dbReference>
    <dbReference type="GeneID" id="56597824"/>
    <dbReference type="KEGG" id="bps:BPSS0288"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6390"/>
    <dbReference type="eggNOG" id="COG5042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GINTKGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PTHR38643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266194" evidence="1">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="38382" checksum="8B33318278EEFC68" modified="2004-10-25" version="1">MLTRSIFSAAVFSLAACAMAPSVAQNNGEAFAEAGAQGRPAKVMIISMFGPEGQAWLDRLGPWKDVAVPGLSPDYPNVHCNKQDVCVVTTGMGYANAASTIMALTFSRRFDLRRTYFLISGIAGVDPARGTLGTAAWAKYLVDFGLQWELDAREIPAGWNGGYLGINTKSPSDKPPLDYRTEVFELNGKLADTAYALSRNVQLADSAQAQAARAKFNYAPANQPPVVTRCDTSSGNTWFSGTLLGERARQWTKLLTDNKGTYCMTAQEDNATFEALKRAASVNRVDLSRVAVLRTGSDFDRPYQGQTSVDNLLNYADQGGFPLATENLYRAGNPLVQDIATHWGEWKDGVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU8</accession>
    <name>Q63NU8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6 8">Proline iminopeptidase</fullName>
            <shortName evidence="6">PIP</shortName>
            <ecNumber evidence="4 6 8">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pip</name>
        <name evidence="10" type="ordered locus">BPSS0201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 8">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6 8">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 6 8"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009923076.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110221.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0201"/>
    <dbReference type="ESTHER" id="burma-q62a61">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37646">
        <property type="protein sequence ID" value="CAH37646"/>
        <property type="gene ID" value="BPSS0201"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0201"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6270"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FYQDGAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="312" mass="35144" checksum="B3393518F00EDE20" modified="2004-10-25" version="1">MYPPIEPYAHGFLDTGDGHRVYWELCGNPNGKPAVFLHGGPGSGCSADHRRLFDPARYNVLLFDQRGCGRSTPHASLENNTTWHLVDDIERLRAMIGVERWLVFGGSWGSALALAYAQTHPARVAELVVRGIFTVRRSELLWYYQEGASWLFPDLWEDFIAPIPRAERADLIAAYRRRLTGDDEAAKREAARAWSVWEGRTIALLPNAAHETYFGDAHFALAFARIENHYFVHQGFMEDGQLLRDAHRLADIPGVIVQGRYDVATPARTAWELAKAWPRASLEIVPDAGHAYDEPGILRALIAATDRFARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU9</accession>
    <name>Q63NU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529751.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110220.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0200"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="EnsemblBacteria" id="CAH37645">
        <property type="protein sequence ID" value="CAH37645"/>
        <property type="gene ID" value="BPSS0200"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0200"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6269"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THEVPNN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267401" evidence="6">
        <location>
            <begin position="20"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="837" mass="92087" checksum="C0E928FD67DBE4CF" modified="2004-10-25" version="1">MSIRHATRSVALCSMLALASTLGCTSGAHDAPAAHAPRTAQTAHATAVAAGIAGLREPVRIVRDSVGVSHIYARNTHDLFFAQGYNAARDRLWQLDLWRRQGEGKMAEQFGPRFAAQDRAARLFLYRGDLEAEYASYHPEAKQILQAFADGINAYVREAKADPAKMPPEFRLTGAEPGEWRPESSLIRIYGITRNVTGEVALARQVAAVGLSKALSLNAFEPPVRQTAIPAGVDVGLIDKRILADYLLARNGLPFRAEDFPRSPLGAAQRDALAARLNAARLTLADDSANPLAPRYESNNWVVAGARTASGKPLLANDPHRRIGMPSLRYMVHLHAPGWNVIGAGEPALPGVSVGHNDRVAFGLTIFAFGDEEDLYVYDTRPGHPDEYRYRGRWEKMRIVEETVAVRGQANRVERLAFTRHGPVLYEDAAHRKAYALRAAYLEFPGTAAYLASLRLDQARDWPSFVAGMRRHYVPGENMVYADVDGNIGWFGGALAPIRREADWSGALPVPGDGRYEWAGLTEGEALPHVLNPAAGYIATANAYDLPDGYRYVDRSAHVWAEPFRQRRLDEVLRGASGLTVADMQRLQYDDRSLPAQAMLGFASQLKADEPGTRDALARLARWSGDMAIDSVPATIYEFWMREVMRRVRDVEVPAAARDAFPKLEVRQVLRYLQQPDGAFGADPVAGRDALLLAALRDGLANARAKLGENVDAWRWGRLHHAQFDHQLAGVLPAFGAFGTERYAVGGNDDTVHRGTYRPSDFRQTSGASYRQVIDVADWDRSMIQNTPGQSGDPRSPFHANLLKGWASGEYWPMAFSDRAVDALAHDTLILEPAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NX7</accession>
    <name>Q63NX7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188308.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110192.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63NX7"/>
    <dbReference type="STRING" id="272560.BPSS0171"/>
    <dbReference type="EnsemblBacteria" id="CAH37616">
        <property type="protein sequence ID" value="CAH37616"/>
        <property type="gene ID" value="BPSS0171"/>
    </dbReference>
    <dbReference type="GeneID" id="56596918"/>
    <dbReference type="KEGG" id="bps:BPSS0171"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6233"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NLMKYCL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03344">
        <property type="entry name" value="VI_effect_Hcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="17542" checksum="8A41719F640D8BB8" modified="2004-10-25" version="1">MAQDIFLKIDGINGESLDDSHKDEIEVLNWNWEIQQESTMHTGSGGGAGKASVKDLTFEHAIDRASPNLMKYALTGKHVDQAVLVMRKAGGNPLEYLKLTMSDVIITRVRPSGSRDDTERSRETVSLSFAKVKQEYVVQNAQGGSGGAVTTSFDIKGNKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NY7</accession>
    <name>Q63NY7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative siderophore biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205355.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110182.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0161"/>
    <dbReference type="EnsemblBacteria" id="CAH37606">
        <property type="protein sequence ID" value="CAH37606"/>
        <property type="gene ID" value="BPSS0161"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0161"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6221"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HIFANNY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="34094" checksum="888C72E8F4E8AC40" modified="2004-10-25" version="1">MNDLFLPRAVSLEPLTSDAGAPCSFGVLVKPRRARTHVGELSIEWLRALVRSQQLVVLRGFDSFADAPGMTRYCAAFGEIMMWPFGAVLELREQANPVDHVFASSYVPLHWDGMYLETVPEFQVFQCVQAIGDAHGGRTTFSSTTEALRVATPEARALWQRAHGRYRRTVELYSNTVEAPIVERHPRREFPILRFCEPPIADDPTFINPSSYTFGGIADSERDALLGSLTRALYDPRAHYAHRWRTGDVVLTDNFTLLHGRERFTSRSGRHLRRVHIHGDPPLRNPHLSKQPHDAAAADAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P86</accession>
    <name>Q63P86_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532659.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110083.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0059"/>
    <dbReference type="EnsemblBacteria" id="CAH37502">
        <property type="protein sequence ID" value="CAH37502"/>
        <property type="gene ID" value="BPSS0059"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0059"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6065"/>
    <dbReference type="eggNOG" id="COG3609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QWAADKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022789">
        <property type="entry name" value="ParD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03693">
        <property type="entry name" value="ParD_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9792" checksum="8DF46CAB40A83DDF" modified="2004-10-25" version="1">MRTTRTLSISLPYEMADYIRAKVSTGEFATESEVIRDALRTLIARDRVVEAWLRDAVNSGEFALDPDAQWAADKDEAKPARPRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PA0</accession>
    <name>Q63PA0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
            <ecNumber evidence="2">5.5.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcaB</name>
        <name evidence="2" type="ordered locus">BPSS0045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110069.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0045"/>
    <dbReference type="EnsemblBacteria" id="CAH37488">
        <property type="protein sequence ID" value="CAH37488"/>
        <property type="gene ID" value="BPSS0045"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0045"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3956"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRATPMI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047472">
        <property type="term" value="F:3-carboxy-cis,cis-muconate cycloisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012789">
        <property type="entry name" value="Protocat_PcaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02426">
        <property type="entry name" value="protocat_pcaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="1">
        <location>
            <begin position="379"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="465" mass="49431" checksum="761E4E190073B8C8" modified="2004-10-25" version="1">MDNKRNSSFSIDPMLEDSARLTALVCGSEPLNRIWSPHATLQRMLDVEAALARALAANGVIPANAVRPIEAACAASELDAQALMRDAALGGNIAIPLVRQLTARVKVRDAEAAKYVHWGATSQDIIDTAAVLQLRDTLDWLDPLLRDTCTALATLAAAHRTTPMIGRTWLQQALPITLGLKFAQWLDALLRHRERIVALRERALALQFGGAAGTLASLRDAAPAVARSLADDLRLALPAVPWHTQRDRIAETAACFGMLIGTLGKIARDISLSMQTEIGELAEPAAAGKGGSSTMPHKRNPVGCAAVLTAAVRAPGLVSTVLAGMVQEHERALGGWQAEWDALPELARLAGGALAQVAQIVEGLNVDVARLADNLDATRGLVLGEAVMLALGDRIGRLDAHHLVERASKQAVRSGRPLYDVLAADPDVAAHLTPQALRQLLDPAHYVGEAHAYVDAVLALHASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI8</accession>
    <name>Q63PI8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional protein PutA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Proline dehydrogenase</fullName>
                <ecNumber evidence="2">1.5.5.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">Proline oxidase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="2">P5C dehydrogenase</shortName>
                <ecNumber evidence="2">1.2.1.88</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">putA</name>
        <name evidence="10" type="ordered locus">BPSL3389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Oxidizes proline to glutamate for use as a carbon and nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the proline dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2"/>
    <dbReference type="EC" id="1.2.1.88" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524499.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109981.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3389"/>
    <dbReference type="EnsemblBacteria" id="CAH37400">
        <property type="protein sequence ID" value="CAH37400"/>
        <property type="gene ID" value="BPSL3389"/>
    </dbReference>
    <dbReference type="GeneID" id="56527765"/>
    <dbReference type="KEGG" id="bps:BPSL3389"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1805"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PPWNFPV"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025703">
        <property type="entry name" value="Bifunct_PutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005933">
        <property type="entry name" value="Delta1-pyrroline-5-COlate_DH-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041349">
        <property type="entry name" value="PRODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024090">
        <property type="entry name" value="PRODH_PutA_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024089">
        <property type="entry name" value="PRODH_PutA_dom_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024082">
        <property type="entry name" value="PRODH_PutA_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14850">
        <property type="entry name" value="Pro_dh-DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18327">
        <property type="entry name" value="PRODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000197">
        <property type="entry name" value="Bifunct_PutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81935">
        <property type="entry name" value="SSF81935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01238">
        <property type="entry name" value="D1pyr5carbox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PRODH" evidence="9">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_dh-DNA_bdg" evidence="8">
        <location>
            <begin position="144"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_dh" evidence="7">
        <location>
            <begin position="266"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="652"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="873"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000197-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1309" mass="139935" checksum="C697BD91E2BA746E" modified="2004-10-25" version="1">MASTTLGVKVDDLLRARLKDAASRLERTPHWLIKQAIFAYLERIEHGQLPPELSGHTGVADLSDSHADGDDDGAPHPFLEFAQSVQPQSVLRAAITAAYRRPEPECVPFLIGEARLPASLASDVQAMAAGLVEALREKSSGGGVEGLIHEFSLSSQEGVALMCLAEALLRIPDRATRDALIRDKISKGDWRSHVGHAPSLFVNAATWGLMITGKLVTTNSEAGLSSALTRLIGKGGEPLIRKGVDMAMRLMGEQFVTGETISEALANSRKYEARGFRYSYDMLGEAATTEEDALRYYASYEQAIHAIGKAAGGRGIYEGPGISIKLSALHARYSRSQQERTMNELLPRVRSLALLARRYDIGLNIDAEEADRLELSLDLLEALCFDPELAGWNGIGFVVQAYQKRCPFVIDYLVDLARRSRHRLMIRLVKGAYWDSEIKRAQVDGLEGYPVYTRKIYTDVSYLACAKKLLAAPDAVYPQFATHNAYTLAAIYHLAGQNYYPGQYEFQCLHGMGEPLYEEVTGRDKLNRPCRVYAPVGTHETLLAYLVRRLLENGANTSFVNRIADKTVSVKELVADPVEDALKVVPLGAPHAKIALPRELYGASRVNSMGLDLSNEHRLASLSSALLASAHHPWRAAPMLADDALAHAAPRDVRNPADLRDVVGTVSEATPDEVSAALAHAVAAAPIWQATPVDARADCLARAADLLEAQMHTLMGLIVREAGKSLPNAIAEIREAVDFLRYYSAQIRDEFSNDTHRPLGPVVCISPWNFPLAIFMGQVAAALAAGNTVLAKPAEQTPLIAAQAVRLLRDAGVPAGAVQLLPGNGETVGAALVADPRTRAVMFTGSTEVARLINKTLSSRLDPDGRPIPLIAETGGQNAMIVDSSALAEQVVADVLQSSFDSAGQRCSALRVLCLQDDVADRTLTMLKGAMRELALGNPDRLSVDVGPVIDADAKRTIDTHIAAMKDKGHAVTQLEMPDACAQGTFVPPTIIEIGNVDELKREVFGPVLHVVRYRRSGLDKLLEQIRATGYGLTLGIHTRIDETIAHVISRAHVGNIYVNRNVIGAVVGVQPFGGEGLSGTGPKAGGALYLQRLLATRPAGLPRSLEAALVADAPQEGETRDNPSAALTALRDWLIEQREPALAARCDGYLSHVLAGATAVLSGPTGERNTYTLGARGTVLCIAATASGARAQFAAALATGNRALFAGAAGEALAAALPAQLKAHAGVRKQADAAFDAVLFEGDSDELLALVKEVAQRPGPIVSVQGVAAGAFENGGDEDYALERLLTERSVSVNTAAAGGNANLMTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PQ7</accession>
    <name>Q63PQ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BcrAD_BadFG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109912.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3316"/>
    <dbReference type="EnsemblBacteria" id="CAH37329">
        <property type="protein sequence ID" value="CAH37329"/>
        <property type="gene ID" value="BPSL3316"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3316"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1899"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFSPAIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="8"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="29696" checksum="F9E318EFE6D61BE2" modified="2004-10-25" version="1">MGNDIFLIGIDGGGTGTRAVLADARGRELAQGSAGPSGLALGIEAAWRSIEAASAEACARAGVAFDWRHCVLGCGLAGVNHRAWLNAFRASAPLAALAIESDAYTTVVGAHGGAPGVIVALGTGSIAAALDASGACRIAGGYGFPSGDEASGAWLGLRALSYAQQALDGRAPLDALARALVAHTGAPDRDALIVWSCEANQTAYAQLAPIVLAHRDHPAAAHWIEQAGIEIGRMIDALDPAAALPVALCGGLAQALASAVPEPHGARLVAPQADSAHGALRLAEREAARLGLTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PS7</accession>
    <name>Q63PS7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525695.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109892.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3296"/>
    <dbReference type="EnsemblBacteria" id="CAH37309">
        <property type="protein sequence ID" value="CAH37309"/>
        <property type="gene ID" value="BPSL3296"/>
    </dbReference>
    <dbReference type="GeneID" id="56527850"/>
    <dbReference type="KEGG" id="bps:BPSL3296"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1921"/>
    <dbReference type="eggNOG" id="COG3865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DQDEVDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="166" mass="18134" checksum="02FA6FA9F31682C8" modified="2004-10-25" version="1">MTARVQRITPFLWFDGNAEEAATFYVSVFDNARLTRVARYGKEGAQASGQGEGAVMTVAFELDGQSFVALNGGPVFQFNPAVSFVVNCATQDEIDYYWGRLSEGGDASAQQCGWLRDRFGLSWQIVPVQLPELLAGDDPAKASRTMQALMQMKKIDLGALRRAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY0</accession>
    <name>Q63PY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197906.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109838.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3244"/>
    <dbReference type="EnsemblBacteria" id="CAH37255">
        <property type="protein sequence ID" value="CAH37255"/>
        <property type="gene ID" value="BPSL3244"/>
    </dbReference>
    <dbReference type="GeneID" id="56594585"/>
    <dbReference type="KEGG" id="bps:BPSL3244"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1991"/>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WWHWAVT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266524" evidence="1">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="198" mass="20778" checksum="80CD231AC52DB32C" modified="2004-10-25" version="1">MRVGRRAVPRGSSRRLLSLALVCACALAPVGGSRALAEDAFMLTSDDLHPGGRVGAPHVFNQGDCKGGNRSPQLAWRNPPPGTKGFAITMFDPDAPGRGWWHWAVVGIPASVSSVPADASASGFLRKLGAAEARNDFGTDGYGGPCPPPGKPHRYVITVHALKATDLRVATGRPAQMFDHEIGTESIGSAQLVVTYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY7</accession>
    <name>Q63PY7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109831.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3237"/>
    <dbReference type="EnsemblBacteria" id="CAH37248">
        <property type="protein sequence ID" value="CAH37248"/>
        <property type="gene ID" value="BPSL3237"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3237"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3692"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYLRFGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="228" mass="25293" checksum="5FCB8617058B7EEF" modified="2004-10-25" version="1">MHKPLYGLFEEPTMNKPDLRPAESVGIAGPAPVLVRELASGDRQQLLTHFLALGEEDRLLRFGQAVPDHVIENYVRTMDFGRDTVFGVFDHALELIGVGHLAYLPAEGDKRTAEFGVSVLERARGQGVGTKLFERAAIRSRNTHVTTLYMHCLSHNATMMHIAKKSGMRIEYAYGEADAYLSLPPADHSTIIAEMMQEQAAVFDYALKRQARRATQIFESLLPAGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QB3</accession>
    <name>Q63QB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521949.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109705.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3110"/>
    <dbReference type="DNASU" id="3094306"/>
    <dbReference type="EnsemblBacteria" id="CAH37121">
        <property type="protein sequence ID" value="CAH37121"/>
        <property type="gene ID" value="BPSL3110"/>
    </dbReference>
    <dbReference type="GeneID" id="56528077"/>
    <dbReference type="KEGG" id="bps:BPSL3110"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2132"/>
    <dbReference type="eggNOG" id="COG3522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LELKFWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="448" mass="49759" checksum="002239EEEBE97C62" modified="2004-10-25" version="1">MSYSAKVLWGEGLFLRPQHFQRQDAYHEARLFESIQAIQPYNWGVRSVRFDRDALGSNVLRASELSLVFPDGALYSAPQADELPPPIALDTLPEGINEFTFYLALHPLRETGSNYADDRDAGFVSRFVSEQASVADHFTDAAEADITFLKTNVKLIAHSEPRDQLLSIPLVRVRRTATSGFEIDDGFVPPCLAIEASPILHQRLRQLIDALQAKVNALYGFHREPTKNIIEFRSGDIASFWLLHTASAAFAALAHLHQHSALHPERLFQELLRLAGQLMTFSKGYVLADLPAYRHDDPGPGFARLDSILRELLETVISTRYFAITLEEVRPSFHVGRLDSGKIDDKTAFYLAVSADMPSVELVDAVPARFKVGAPDDVDKLVLSAMPGVRLAYTPQVPPAIPVRPGACYFALDARSPLYERMLQAQSAMIYAPSGINDLKFELIAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QC8</accession>
    <name>Q63QC8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555447.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109690.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3095"/>
    <dbReference type="EnsemblBacteria" id="CAH37106">
        <property type="protein sequence ID" value="CAH37106"/>
        <property type="gene ID" value="BPSL3095"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3095"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2149"/>
    <dbReference type="eggNOG" id="ENOG5033EKV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGAWRWQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="328" mass="32480" checksum="CE887B941880D320" modified="2004-10-25" version="1">MSAPDDSNSKAPPSLLSSDAGKGSGANHSRILANLEGRVSPQTENAPRSRKGPIALIALAVVAIAGWGAWRLQQPSADSAEVAAAASAPAVAAAPASRAAPASAAQIAPASAPQPATIVNDESAASAAKPAVAASAGDGSRLSRALANGASDVSTAGAAAGATAAAAAVAAAKPAKSAEKRAAAKPDKQDAAHAKAEAAARKRHEKAQAADAAQAKKSRREAAAKKNGKDDPDADLLAALVARTKPADATKPADATKPADAAKPSTSAAPKKAAAAATTSADTSLAARVKACSERGFFEDQLCRWRVCENHWGKDPACPTSATQNRQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI7</accession>
    <name>COQ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-demethoxyubiquinol 3-hydroxylase</fullName>
            <shortName evidence="1">DMQ hydroxylase</shortName>
            <ecNumber evidence="1">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coq7</name>
        <name type="ordered locus">BPSL3035</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527787.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109631.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QI7"/>
    <dbReference type="SMR" id="Q63QI7"/>
    <dbReference type="STRING" id="272560.BPSL3035"/>
    <dbReference type="EnsemblBacteria" id="CAH37047">
        <property type="protein sequence ID" value="CAH37047"/>
        <property type="gene ID" value="BPSL3035"/>
    </dbReference>
    <dbReference type="GeneID" id="56528159"/>
    <dbReference type="KEGG" id="bps:BPSL3035"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2231"/>
    <dbReference type="eggNOG" id="COG2941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPLWYGG"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="PTHR11237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000338670" description="3-demethoxyubiquinol 3-hydroxylase">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01658"/>
        </source>
    </evidence>
    <sequence length="208" mass="22593" checksum="45C2E2D279BD4800" modified="2004-10-25" version="1">MVFDELITEFDRGLRSIAGVSRMSRPVPKPAAAAPAELSAAERKHAAGLMRVNHVGEVCAQALYQAQKLTTSSAGLKEMFEHAAREEEDHLAWTAHRLKDLDSRPSLLNPLWYAGALAIGVVAGRLGDKMSLGFMAETERQVESHLDGHLSELPAADVESRAIVEQMRADEVKHGKSATDAGGIELPMPARMLMRAASKVMTSTAYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QK3</accession>
    <name>Q63QK3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.27" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522021.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109615.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3019"/>
    <dbReference type="EnsemblBacteria" id="CAH37031">
        <property type="protein sequence ID" value="CAH37031"/>
        <property type="gene ID" value="BPSL3019"/>
    </dbReference>
    <dbReference type="GeneID" id="56528175"/>
    <dbReference type="KEGG" id="bps:BPSL3019"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2248"/>
    <dbReference type="eggNOG" id="COG0678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYINHPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PTHR10430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="168" mass="17754" checksum="38447896F565C15E" modified="2004-10-25" version="1">MIQVGDTLPDAQLFEYLDDARAGCTPGPNAFGVREQTAGKRVVIFGLPGAFTPTCSAQHVPGYVAHAEPLRSAGIDEIWCVAVNDAFVMGAWGRDLHTAGKVRMMADGSAAFTHALGLTQDLSARGMGIRSRRYAMVVDDGVVKTLFVEAPGKFEVSDAASVLAGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM9</accession>
    <name>Q63QM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538773.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109589.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2994"/>
    <dbReference type="EnsemblBacteria" id="CAH37005">
        <property type="protein sequence ID" value="CAH37005"/>
        <property type="gene ID" value="BPSL2994"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2994"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2276"/>
    <dbReference type="eggNOG" id="COG4137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLVLTVY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="2">
        <location>
            <begin position="61"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="32138" checksum="BBD76371CF2C3FA2" modified="2004-10-25" version="1">MDIVLYALTVLLYGGLAVAGWRARRVGAARPLVASVPAVAPARESAPGGMGGLGRTILGAALLAHGVLLHMTIFPHDAMVFGFAFALSAMFWLGAGIYWIESFFFPLDGMRLLVLPLAGVASLLPLAFGGVRVLPYAAAPLFKVHFLIANIAYGLFAIAALHAVLMLMVERRLHALRHDGLRDASGWVAGWLDTLPPLLTLEKLLFRLIGAGFVLLTLTLATGILFSEQIDARALKLDHKTVFAILSWLMFGGLLVAHKASGWRGRGAARWVLASFVALLLAYVGSRFVLEVLLHRSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QN0</accession>
    <name>Q63QN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL2993a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194409.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109588.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2993a"/>
    <dbReference type="EnsemblBacteria" id="CAH37004">
        <property type="protein sequence ID" value="CAH37004"/>
        <property type="gene ID" value="BPSL2993a"/>
    </dbReference>
    <dbReference type="GeneID" id="56594246"/>
    <dbReference type="KEGG" id="bps:BPSL2993a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2277"/>
    <dbReference type="eggNOG" id="ENOG5033BBV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EPMIRCV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="106" mass="10858" checksum="B93C9047CF00ACB2" modified="2004-10-25" version="1">MRQILLLIVLFFASSWVARKIRQAQARGDGPFAGGAGRTADSASGGGGATQAGRPRDAALPEPMVRCAECGVHAPKSDAVVAGGEYFCSPEHAARHAAHSGSRSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R30</accession>
    <name>Q63R30_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycolate oxidase subunit GlcE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glcE</name>
        <name evidence="2" type="ordered locus">BPSL2844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544243.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109438.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2844"/>
    <dbReference type="EnsemblBacteria" id="CAH36854">
        <property type="protein sequence ID" value="CAH36854"/>
        <property type="gene ID" value="BPSL2844"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2844"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2457"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLNASCW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="38781" checksum="B9A224ED9E4582B5" modified="2004-10-25" version="1">MEEDDIVAGWAARIRDAAASGRALRIRGGGTKDWYGQALDGEILDTRAHHGIVSYDPAELVVTARAGTSLAELEATLAERGQMLPFEPPHCGRGATLGGAVAAGLAGPRRATTGAPRDFVLGVAILNGRGDRLRFGGQVVKNVAGYDVSRLMAGSLGTLGLMLELSVKVLPVPAAELTLKFDMSATDAVRKLNEWAGRPFPLSASAWRYGTLVLRLSGAEAAVKSAKTVLGGEAVDAVEAERFWEGVREQNDPFFSSLAPGHALWRLSLPSITEPMHLPGTQMMEWGGAQRWWITDADAQTVRMSAKQAGGHATLFRASESYDRSAGVFTPLPAPLMKIHRGLKTAFDPARIFNRGRLYPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF0</accession>
    <name>Q63RF0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane transport solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527622.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109318.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2722"/>
    <dbReference type="EnsemblBacteria" id="CAH36730">
        <property type="protein sequence ID" value="CAH36730"/>
        <property type="gene ID" value="BPSL2722"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2722"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2605"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YELSESC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005698775" evidence="1">
        <location>
            <begin position="40"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="347" mass="36629" checksum="38855FE20DDE22A3" modified="2004-10-25" version="1">MLKRTAAERGAPALRAAFTLPFAAAAMAAAAIVATVATAAEANAYPVTVRSCGRDVTFERAPARAVSNDVNLTEMMIALGLQTRMAGYTGIAGWKTGNARLRAALAGVPELATHYPSLEALVDARADFYFAGWNYGMHPGGPVTPASLERFGIRTYELTESCSLVMRRPPASLDDVYRDLANLGRIFGVDARAAQVAGAMRARIDAVRRTLASAAGGGTPPRVFVYDSGTDKPMTAGALAMPTALIAAAGGRNVMDDVPRGWTQVGWESVVARDPQAIVIVDYSAVTAEQKKQFLLSQPALAQVEAIRARRFIVIPYDAATPGVENAAAVETIARGLHPRAFAKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RG6</accession>
    <name>Q63RG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522238.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109302.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2706"/>
    <dbReference type="EnsemblBacteria" id="CAH36714">
        <property type="protein sequence ID" value="CAH36714"/>
        <property type="gene ID" value="BPSL2706"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2706"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2628"/>
    <dbReference type="eggNOG" id="ENOG502ZB7P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRVGYSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021340">
        <property type="entry name" value="DUF2957"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11170">
        <property type="entry name" value="DUF2957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267478" evidence="1">
        <location>
            <begin position="24"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="532" mass="54504" checksum="9E7BA2F7E6A777D5" modified="2004-10-25" version="1">MLCIPNLRAAVLSCMVAVMPFVAGCGGGDDPGPIQVGQCTGGSCPPSGPSTTPPTVTKLCPDALDYSTTYTGGSGSGEYVKVKFDTAKKTYQMQFIASSVPTSAGQINNTRAGLTISGTFHNATGLPTAEQNRCAFVLDNGATSDGAYSVTINRADPPMLFVGMGVVGGGIPGATIAFPGLELFPGFTIGTVPSRSFDFYPFIGFTDTETDFTKVAGVYNEVGVHLQPTGTSFQTAAPQGWQPDVVNWTQTLNADGSCTITPGSDYSCRTTGTPWTLRKNTDGTSDNVFVSRPPPSQPYPSAGQGQPLVIVTPSQAQGVMIVGKLNGQLVPVVIRVGYANVDAGNPLASVADAEIGISVLAPAAAVAANSLQGGYIGATSAVACGVVSFGGSSNAPASSGSAFDNTAPHPELPGTYRGGFFYPSAGNCTDGSAVSTLAANYTSTLFQGATAAFLDPMTSAVSAQFSLDYTQTAPGKIKVTATRDFNAQGSAGTVAVFKKGDYGWLIKVGNVYGMVVNNSQYNPFFTVGAFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RN1</accession>
    <name>Q63RN1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sir2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938464.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109237.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2641"/>
    <dbReference type="EnsemblBacteria" id="CAH36649">
        <property type="protein sequence ID" value="CAH36649"/>
        <property type="gene ID" value="BPSL2641"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2641"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3011"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGFWNAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="150"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="416" mass="45766" checksum="D2C3BB1AC285E9F9" modified="2004-10-25" version="1">MAEECRARRVDAESFARDIWLGVHRQLKASPPIRAEMDFIVEWAQSAPALQRAGRRRVDRAPGAPVDARRPLGRASLVARRPPPVARDSSFVVSRSKRFRPCAARAYDRSHFERNPERKSRAMSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRRWIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSSCSAYTWDAESFAPVVDEPACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWLARAGRVAVVEVGAGTAVPTVRAFSERTGDDVIRINVREAHARRDDVIGLPGGALETLRALDAAWRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RQ8</accession>
    <name>Q63RQ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ordered locus">BPSL2613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185596.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109209.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2613"/>
    <dbReference type="EnsemblBacteria" id="CAH36621">
        <property type="protein sequence ID" value="CAH36621"/>
        <property type="gene ID" value="BPSL2613"/>
    </dbReference>
    <dbReference type="GeneID" id="56594863"/>
    <dbReference type="KEGG" id="bps:BPSL2613"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2741"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="226" mass="23925" checksum="C4ABC7693BD73719" modified="2004-10-25" version="1">MIEVHAFETPRAQTEALAQAVGEALAATLAQRARATLAVSGGTSPRPFLQTLSGAALDWPRIDVTLVDDRWVPDTDDASNAKLVRETLLRNAAAHARFAPLVDLRESLDAQIAALNQSPAHPLPDVAVLGMGEDGHTASIFADAPEWDHAIATTERFVGVHPGAAPHARVSLSLGALKRIGRVFLLIAGSRKRAVLEAAAAAPQKNAISQLANDKGTKLDVYWCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR4</accession>
    <name>Q63RR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522307.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109203.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2607"/>
    <dbReference type="EnsemblBacteria" id="CAH36615">
        <property type="protein sequence ID" value="CAH36615"/>
        <property type="gene ID" value="BPSL2607"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2607"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2748"/>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIWCILG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="22394" checksum="727E9283326B51DD" modified="2004-10-25" version="1">MHPRLTLAIAVLEAIATLAFAISGFVEARKNRLDSVGTFVVALATAFGGGTMRDVLLERRPFYWVEHQAYVIAIFGLSLVAPLVLRMASRLSAERLLLAADAIGLGIFSISGTSIALDAQMPRFVAAMMGVTTGVFGGVIRDVLCNDIPLILRDSRPYATCAFAGCWVYLLLVWLQFDSVYSVLAATAFILVARLVTYQLDIRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RS2</accession>
    <name>Q63RS2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541356.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109195.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36607">
        <property type="protein sequence ID" value="CAH36607"/>
        <property type="gene ID" value="BPSL2599"/>
    </dbReference>
    <dbReference type="GeneID" id="56594878"/>
    <dbReference type="KEGG" id="bps:BPSL2599"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2757"/>
    <dbReference type="eggNOG" id="ENOG5033DV6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SINHWGT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="90" mass="9763" checksum="8362BC772966E732" modified="2004-10-25" version="1">MAISVKNSASNTVEVSINHWGTDGDTKPFKMAPGASDSWNRTDLRGFVMYVQLGGSATPYYVLSTSNIVIYDDKVTDSGQTLLPANKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S91</accession>
    <name>Q63S91_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sigma E factor regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RseB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524615.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109026.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2434"/>
    <dbReference type="EnsemblBacteria" id="CAH36437">
        <property type="protein sequence ID" value="CAH36437"/>
        <property type="gene ID" value="BPSL2434"/>
    </dbReference>
    <dbReference type="GeneID" id="56528750"/>
    <dbReference type="KEGG" id="bps:BPSL2434"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2956"/>
    <dbReference type="eggNOG" id="COG3026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DDFRYQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16327">
        <property type="entry name" value="RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033436">
        <property type="entry name" value="MucB/RseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038484">
        <property type="entry name" value="MucB/RseB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033434">
        <property type="entry name" value="MucB/RseB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005588">
        <property type="entry name" value="MucB_RseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38782">
        <property type="entry name" value="PTHR38782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03888">
        <property type="entry name" value="MucB_RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17188">
        <property type="entry name" value="MucB_RseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005427">
        <property type="entry name" value="RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267496" evidence="5">
        <location>
            <begin position="36"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="MucB_RseB" evidence="6">
        <location>
            <begin position="47"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="MucB_RseB_C" evidence="7">
        <location>
            <begin position="245"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="350" mass="38630" checksum="8B7483CAF2BFAD60" modified="2004-10-25" version="1">MRTLQLNQAILGWRRLPALLLCAAALLSAQPRAFAQPDDPVATRRQAAEWLDRIQQAAQQQNYEGTFVYQRGAYVQSSRIVHVATKGDGEYERVESLDGKPRKLLRHNDDLYTFVPERRLCVVERRQNKDSFPALLGASGEQVLSVYEPKSLGRDRVAGLDAQVVELVPKDAYRFAYKLWTDAKTGLLLRSQTLDTDDRVLEQIAFSQLQLGAAAPSQKTAIAAGMRNLGGWTVVRPPVAPVDIEAQGWQIAPTVAGFRKIREVRRPMAARDANDPPIAVDQAVFTDGLATISVFIEPAEKNSRKEGAGGTGATHVLVKRRGDFWITVLGEAPPSTLQQFASAIEYKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE3</accession>
    <name>Q63SE3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bo(3) ubiquinol oxidase subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome o ubiquinol oxidase subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Oxidase bo(3) subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquinol oxidase polypeptide III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquinol oxidase subunit 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cyoC</name>
        <name evidence="19" type="ordered locus">BPSL2380</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooctamer of two A chains, two B chains, two C chains and two D chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544233.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108973.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2380"/>
    <dbReference type="EnsemblBacteria" id="CAH36382">
        <property type="protein sequence ID" value="CAH36382"/>
        <property type="gene ID" value="BPSL2380"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2380"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3025"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIYWWGS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009486">
        <property type="term" value="F:cytochrome bo3 ubiquinol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02863">
        <property type="entry name" value="Ubiquinol_oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014206">
        <property type="entry name" value="Cyt_c_ubiqinol_oxidase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033946">
        <property type="entry name" value="Ubiquinol_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02842">
        <property type="entry name" value="CyoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="18">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAH36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="201" mass="22093" checksum="C40E3D293EE0B579" modified="2004-10-25" version="1">MSHNTMTLDHAASHDHPPSHSVFGFWLYLMTDCVLFAALFATFAVLGNQFAGGPTAKDLFDIPGVALETAALLLSSITYGFAMIGAHQRRRGAVFGWLAVTFVLGAAFLAMELREFSHLVAEGAGPQRSAFLSSFFTLVGTHGLHVTAGLVWMAVLVAQALRRPELTERDIRRLTCLSLFWHFLDIVWICVFSFVYLASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE9</accession>
    <name>Q63SE9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108967.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2374"/>
    <dbReference type="EnsemblBacteria" id="CAH36376">
        <property type="protein sequence ID" value="CAH36376"/>
        <property type="gene ID" value="BPSL2374"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2374"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3033"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PWSREMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017776">
        <property type="entry name" value="FeS_assembly_SufT_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03406">
        <property type="entry name" value="FeS_long_SufT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="182" mass="19250" checksum="A679245A6B7A3CA7" modified="2004-10-25" version="1">MRRSRESVVLRRPVKVECVPSGAPLELPAGTAAEITQALGTNFTLVAGGQMVRLRGEDADAIGKPPPGPLDVPDGPVTPDGARACVMRTLKTCYDPEIPVDIVELGLIYGCEIEPAGHDRLKVSITMTLTAPGCGMGEALADEVADKVLALPFVGEVNVDMVFDPPWDRSRMSEAAMLTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SG8</accession>
    <name>Q63SG8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205163.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108948.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2355"/>
    <dbReference type="EnsemblBacteria" id="CAH36357">
        <property type="protein sequence ID" value="CAH36357"/>
        <property type="gene ID" value="BPSL2355"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2355"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3056"/>
    <dbReference type="eggNOG" id="COG3213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLAWHRH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010266">
        <property type="entry name" value="NnrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05940">
        <property type="entry name" value="NnrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="42068" checksum="9E6BC2CE72616DA2" modified="2004-10-25" version="1">MPLVRSTNHSPLAPPDGRHAALWSTGFRSFYLGGAGFGAIAMLAWLGALAGHDSAGRAAPASGLFWHAHEMVFGFGGAIVSGFLLTSLRTWTSTNPAQGPSLAALWLLWLAGRVLMWTGPGWAAAAVDIALLPAIAYALVRPLIGAKNRHGIFLPVALGMLAALNALFHLWIRQGHADWALRCVDLAAGLLVLFIVIIGGRIIPSITATARPELPVRQWRLVESSVMSVTLAALLADATGAPAPAIAALAAAAAALHAARLVGWRFWAVGRRPMLSILHVAYASIAAGFALTALSAYGFVAHSLALHTFTTGAIGCAIVGMITRTALEHTGREPVAKLAERICYGLLIVATLARVAGPALAPAATAQWLAVAGVGWTAALLVYVVRYAGLLMSPAPSAPGSGARSGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SI0</accession>
    <name>HUTI_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazolonepropionase</fullName>
            <ecNumber evidence="1">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutI</name>
        <name type="ordered locus">BPSL2340</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524690.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108936.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SI0"/>
    <dbReference type="SMR" id="Q63SI0"/>
    <dbReference type="STRING" id="272560.BPSL2340"/>
    <dbReference type="EnsemblBacteria" id="CAH36343">
        <property type="protein sequence ID" value="CAH36343"/>
        <property type="gene ID" value="BPSL2340"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2340"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3079"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000306450" description="Imidazolonepropionase">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <sequence length="407" mass="43787" checksum="0D598C798DB8E369" modified="2004-10-25" version="1">MKSILWHNLKLCAHGDPNDTIADAAIAVNGDGTIAWTGRASDVPAGYVHWPREDLRGAWVTPGLVDCHTHLVYGGQRADEFAQRLAGASYEEIAQRGGGIVSTVRATRDASEAALFEQACARLRPLLAEGVTAIEIKSGYGLELASERRMLRVARQLGERFPVSVYTTFLGAHALPPEYAGRADEYIDEVCERMLPALADEGLVDAVDVFCERIGFTLAQSERVFEAAARRGLPVKMHAEQLSNGGGSALAARYRALSADHLEYLDAAGVAAMRASGTTAVLLPGAYYFIRETKLPPIDLLRRHGVPIALATDHNPGTSPLTSLLLTMNMGCTVFKLTVQEALLGVTRHAAAALGASDRHGSLAPGRQADFAVWPVSTLAELAYWFGRPLCERVVKGGVTVFTRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SU7</accession>
    <name>Q63SU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532163.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108819.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2224"/>
    <dbReference type="EnsemblBacteria" id="CAH36226">
        <property type="protein sequence ID" value="CAH36226"/>
        <property type="gene ID" value="BPSL2224"/>
    </dbReference>
    <dbReference type="GeneID" id="56528968"/>
    <dbReference type="KEGG" id="bps:BPSL2224"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2524"/>
    <dbReference type="OMA" id="GHERYVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="344" mass="38314" checksum="5E814C1CECAE4F74" modified="2004-10-25" version="1">MSASAPASRSFERRPVRVLRVLARRHVDSTRMVRPRDFDTALVAQVPGMSDIGDGERYVPLCVDWRDARLFLSRWDDDCAMTDVPFLYQRQRRTARQLLDVPFEQLEAPGRAARMTPIFIFSVGRCGSTLLSRLLAAVGEQAVSEPDVLTSVAHFDDAAERAAALPARERIVQSCVAAFEPACGPAPIIKLRARCNRAVDVFLNAMPHARYVFMCRNRDDWVRSSSRAFGDSGEALAELLKASVEAFDRMHAARVDPLLVWYEDLLADPLAALRRILRARDDLDAHRAAVERALRADAQEGSGLSRASLAARTGDAGALAAFDARWREIRPEALLREHGLARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SW3</accession>
    <name>Q63SW3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="4">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fpr</name>
        <name evidence="6" type="ordered locus">BPSL2208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191307.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108803.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2208"/>
    <dbReference type="EnsemblBacteria" id="CAH36210">
        <property type="protein sequence ID" value="CAH36210"/>
        <property type="gene ID" value="BPSL2208"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2208"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3238"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PKQDRAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06195">
        <property type="entry name" value="FNR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033892">
        <property type="entry name" value="FNR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="257" mass="28815" checksum="E4F4D31FD86A82A2" modified="2004-10-25" version="1">MSANAHETVLSVHHWNDTLFSFKTTRAPGLRFKTGQFVMIGLEIDGRPLMRAYSVVSAHYDDHLEFYSIKVPDGPLTSRLQHLRAGDKLLVAGKPTGSLIIDNLRPGKHLYLLSTGTGLAPFISVIRDPDYYGAFDKIVLMHGVRWKSELGYFDHITTELPENAYFGDLVRDKLIYYPSVTRETFERQGRLTELIESGKLFDDVGLPPLDPAVDRAMVCGGPSMLADLVEMLERRGFVEGTSHAPGDYVIERAFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T57</accession>
    <name>Q63T57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative amino hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535402.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108709.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2112"/>
    <dbReference type="EnsemblBacteria" id="CAH36115">
        <property type="protein sequence ID" value="CAH36115"/>
        <property type="gene ID" value="BPSL2112"/>
    </dbReference>
    <dbReference type="GeneID" id="56529084"/>
    <dbReference type="KEGG" id="bps:BPSL2112"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3357"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWLAHGI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="81"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="476" mass="51381" checksum="02E2D522487F9A5E" modified="2004-10-25" version="1">MERHPSARAGAHSLSQPPSLSPNRSKTLVVKHADVLVTMDGARRELRDAGLYVEDNRIVAVGPSAELPEQADEVLDLRGHLVIPGLVNTHHHMYQSLTRAIPAAQNAELFGWLTNLYRIWAHLTPEMIEVSALTAMAELLLSGCTTSSDHLYIYPNGSRLDDSIAAARRIGMRFHASRGSMSVGQRDGGLPPDAVVEREADILRDTQRVIETYHDEGRYAMLRVAVAPCSPFSVSRGLMRDAAALAREHRVSLHTHLAENVNDVAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVRLDEPGIALFARTGTGVAHCPCSNMRLASGIAPIARMRRAGVPVGLGVDGCASNDGAQMVAEARQALLLQRVGFGPDALSARDALEIATLGGARVLNRDDIGALAPGMAADFVAFDLRTPQFAGALHDPVAALVFCAPPQAAYSVVNGRVVVREGRLTTLEIEPLVERHNALARALCDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T67</accession>
    <name>Q63T67_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538203.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108699.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2102"/>
    <dbReference type="EnsemblBacteria" id="CAH36105">
        <property type="protein sequence ID" value="CAH36105"/>
        <property type="gene ID" value="BPSL2102"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2102"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3375"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="36822" checksum="4B19D2AFD25DF204" modified="2004-10-25" version="1">MSTSPNRPAHLTINGEPIPTLDEIAAQHFALTPWVMRTPVFERADLPSLDNTHVNFKFELLQASGSFKARGAFTNLLALGEDRKSVGVTCVSAGNHAAAVAYAAMRLGTSAKVVMFDTASPARVALCRHYRAEVVMASSPVEAFEIVRRIEAEEGRFFVHPFNGYHTILGTATLGYEWATQTPDLDAVIVPIGGGGLAAGTSTALRLANPRVHVYGVEPEGADAMSRSFAANHPVRMGAMHTIADSLMAPHTEEYSYELCRRHVDRIVTVSDDALRAAMLYLFAHLKVAVEPACAAATAALLGPLRESLQGRRVGVLLSGTNIDSTALAAHLEHARLHRAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T81</accession>
    <name>Q63T81_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tox-REase-5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BPSL2087A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205126.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108685.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2087A"/>
    <dbReference type="EnsemblBacteria" id="CAH36090">
        <property type="protein sequence ID" value="CAH36090"/>
        <property type="gene ID" value="BPSL2087A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2087A"/>
    <dbReference type="eggNOG" id="ENOG50332ZH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWSEEWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028904">
        <property type="entry name" value="Tox-REase-5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15648">
        <property type="entry name" value="Tox-REase-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tox-REase-5" evidence="2">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="200" mass="22140" checksum="9FCF426C2B505BD1" modified="2004-10-25" version="1">MAGLVFPVIEAAAVELGPILARVGVALLGGATVAGTASLSGDTPKEDSKATPDVRALPRTGESCKKCPPDAGTRIRRNHGVNWNSYRYQARITGFPFDTEACRWSEEWRWLEVDFDGFQPGECMLQETKGNYDQFLDGSIPGAEDFFKGFDSMETQITNQATRVRANPPARLTWYFQTQLTKRKMTPLLSSLGVRSVYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TA1</accession>
    <name>Q63TA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521787.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108665.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2066"/>
    <dbReference type="EnsemblBacteria" id="CAH36067">
        <property type="protein sequence ID" value="CAH36067"/>
        <property type="gene ID" value="BPSL2066"/>
    </dbReference>
    <dbReference type="GeneID" id="56526429"/>
    <dbReference type="KEGG" id="bps:BPSL2066"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2334"/>
    <dbReference type="eggNOG" id="ENOG5032QJR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIFCDVK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008617">
        <property type="entry name" value="Uncharacterised_YcgJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05666">
        <property type="entry name" value="Fels1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266763" evidence="1">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="123" mass="13430" checksum="2C9A75F37D7F3442" modified="2004-10-25" version="1">MKSSVLFMAALPLIAIAASAHAQPRHPAVYSPAAGVLCDRYVCADDQGISRALTERYLGKRVAAKAFSQGDFDPTEFTFANGVFCDVKERLCRDDRYYGADGKRSGAVSRRYTELLFGRRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH8</accession>
    <name>Q63TH8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191536.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108588.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1990"/>
    <dbReference type="DNASU" id="3093645"/>
    <dbReference type="EnsemblBacteria" id="CAH35989">
        <property type="protein sequence ID" value="CAH35989"/>
        <property type="gene ID" value="BPSL1990"/>
    </dbReference>
    <dbReference type="GeneID" id="56595407"/>
    <dbReference type="KEGG" id="bps:BPSL1990"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4142"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACAPMLL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="143"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="293" mass="32230" checksum="A9C48FD461BF8B8E" modified="2004-10-25" version="1">MDDTTPPETPAVDDLLQRIAGAYDTLPRQLKRIASYIDEHRSSVMMDRTSDIAQRCGVHPSAVVRFAQRFGFSGFSDLQAVFKDAYTGQNPTVQSYQQRIRSLIDGEAGPMTGGAVARQFIDASRAGLDELAAGLDDDQFDAAVTMLERAENIYVVGVRRSFPVASYIVYALQHTAKRVHLVSGLGGMYREQIRSVKKGDVVIAISFAPYGKETQYCLRAARHNHAQTLVVTDSRLSPLARDASAHLLVKEGSAFAFRSLTSTICLCQALFIALAYRLELNVEEVKDIGGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TJ1</accession>
    <name>Q63TJ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fosmidomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fsr</name>
        <name evidence="7" type="ordered locus">BPSL1977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192717.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108575.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1977"/>
    <dbReference type="EnsemblBacteria" id="CAH35976">
        <property type="protein sequence ID" value="CAH35976"/>
        <property type="gene ID" value="BPSL1977"/>
    </dbReference>
    <dbReference type="GeneID" id="56595420"/>
    <dbReference type="KEGG" id="bps:BPSL1977"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4129"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YFYMASF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="416" mass="44143" checksum="E2E25687019695E7" modified="2004-10-25" version="1">METSLDNRPSVARAAASPAPAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEFSLSFAQIGLITLTYQITASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNAGSSLGPLLAALIVIPHGQRSIAWFSAAALVAIFVLVQIGRWYRRHPAAKKKAAHAAHPTLSRRQVGLALGVLVMLVFSKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVIWTSILGVAPFTLMLPYANLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFFGLSFGLGGVGAAVLGQLADATSIAFVYKVCSFLPLIGVLTVFLPNVEGRTTLDKQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U07</accession>
    <name>Q63U07_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108409.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1810"/>
    <dbReference type="EnsemblBacteria" id="CAH35809">
        <property type="protein sequence ID" value="CAH35809"/>
        <property type="gene ID" value="BPSL1810"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1810"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3931"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQWTSFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018705">
        <property type="entry name" value="DUF2134_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09977">
        <property type="entry name" value="Tad_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tad_C" evidence="1">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="326" mass="32769" checksum="104E7108377B8758" modified="2004-10-25" version="1">MLWFVLFLPVLLLFGAFAIDLPRVAAARNELQNAADAAALAGAASLEAGAGAPAWAAAASAAAAALSLNASDGAALSSGDVQTGYWNVTGVPAGLEPTTLAPGEYDVPAVQATVTRAPNQNGGPLSLLMGGLLGLVGTPAAATAVAVAGAPATVGAGGLFPMVIDQCVLDQYWDARAGAPRVDPTTGAPYEFQVGNGRTYGGTCYAGQWTTFLVNANDVPTVRGLMAHGNPTPLSIGDSIWIEPGVKTALYYDVPVGVTVVVPVATQISSKTYVPVVAFAAFYVDASDGANLKAITGHFVGGYKIPASASGIGPAYGAYVAPRLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UG9</accession>
    <name>Q63UG9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193126.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108247.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1633"/>
    <dbReference type="EnsemblBacteria" id="CAH35632">
        <property type="protein sequence ID" value="CAH35632"/>
        <property type="gene ID" value="BPSL1633"/>
    </dbReference>
    <dbReference type="GeneID" id="56529352"/>
    <dbReference type="KEGG" id="bps:BPSL1633"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3703"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VSGMTIK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="221" mass="23861" checksum="25322A8AE19A809E" modified="2004-10-25" version="1">MSNVALHTRKVVVADDHPIVLRAVTDYVNSLPGFHVVASVSSGDALLSAMREQEVNLVVTDFTMHQANDDKDGLRLISHLMRAYERTPIIVFTMLTNSGVISQLCRMGVAGLVGKEEEIAELGRVCVSVARGVSQSLSPGMAHRLAAVGSIRPGEAAFNALTPKELEVVRLFTGGMSLTDIARTLNRSLGTVSTQKRSAMRKLHVDTNVDLINCAREQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US1</accession>
    <name>Q63US1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotide phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108145.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1525"/>
    <dbReference type="EnsemblBacteria" id="CAH35526">
        <property type="protein sequence ID" value="CAH35526"/>
        <property type="gene ID" value="BPSL1525"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1525"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3563"/>
    <dbReference type="eggNOG" id="COG2236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WEFNQIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="15"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="21202" checksum="8F3A64FD14DE6089" modified="2004-10-25" version="1">MSDPRNDDKNLWVGWDEYHRLIEMLALAVHDSGWKFDKILCLARGGLRVGDQLSRIYDLPLAILATSSYREAAGTQQGDLDIAQYITMTRGELTGNVLLVDDLVDSGVTLARVQQHLKERYPAVTAVRSAVLWYKGCSKVKPDYHVQYLPTNPWIHQPFEEWDTVRPHNLAAWIKRGNAQRDDASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UY2</accession>
    <name>Q63UY2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Replicative DNA helicase</fullName>
            <ecNumber evidence="4 13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dnaB</name>
        <name evidence="15" type="ordered locus">BPSL1462</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 13"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192724.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108084.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1462"/>
    <dbReference type="EnsemblBacteria" id="CAH35464">
        <property type="protein sequence ID" value="CAH35464"/>
        <property type="gene ID" value="BPSL1462"/>
    </dbReference>
    <dbReference type="GeneID" id="56595802"/>
    <dbReference type="KEGG" id="bps:BPSL1462"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3492"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="14">
        <location>
            <begin position="189"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="460" mass="50699" checksum="8C114D2724AF7EA2" modified="2004-10-25" version="1">MNAPKDPQIESLKVPPHSIEAEQSVLGGLLLDNGAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVVTVYEALTTSGKAEDVGGLAYLNALAQNTPSAANIRRYAEIVRDRAVLRRLVSVADEISADAFNPQGKEVRQLLDEAESKVFSIAEDGARGTQGFLEIGPLLTQVVERIDTLYHTANPSDVTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAVEYGLPVAVFSMEMPGTQLVMRMLGSVGRLDQHRMRTGRLTDEDWPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLARQCGKLGLIIVDYLQLMTGSSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADVILFIYRDEVYNPDSPDKGTAEIIIGKQRNGPIGPVRLTFLGQYTKFDNFAGAQNFYGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V22</accession>
    <name>SELO_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
            <ecNumber evidence="1">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">selO</name>
        <name type="ordered locus">BPSL1422</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:54289"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:54293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:58121"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SELO family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH35424" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EC" id="2.7.7.n1" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35424.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538218.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108044.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V22"/>
    <dbReference type="SMR" id="Q63V22"/>
    <dbReference type="STRING" id="272560.BPSL1422"/>
    <dbReference type="PRIDE" id="Q63V22"/>
    <dbReference type="EnsemblBacteria" id="CAH35424">
        <property type="protein sequence ID" value="CAH35424"/>
        <property type="gene ID" value="BPSL1422"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1422"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3441"/>
    <dbReference type="eggNOG" id="COG0397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000271813" description="Protein adenylyltransferase SelO">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="521" mass="57660" checksum="1F3D2AF5792F5CA1" modified="2007-01-09" version="2">MSFSRSEAAPAAPLPDLAATLAAPRDDAFQQLGAAFVTRLPAAPLPAPYVVGFSDDAARMLGLEPALRDAPGFAELFCGNPTRDWPQASLPYASVYSGHQFGVWAGQLGDGRALTIGELAHDGRRYELQLKGAGRTPYSRMGDGRAVLRSSIREFLCSEAMHHLGIPTTRALAVIGSDQPVVREEIETSAVVTRVAQSFVRFGHFEHFFANDRPEQLRALADHVIERFYPACRDADDPYLALLAEATRRTAELVAQWQAVGFCHGVMNTDNMSILGLTIDYGPFGFIDAFDAKHVCNHSDTQGRYAYRMQPRIAHWNCFCLAQALLPLIGLHRDAPSEDARAERAVEDAHAVLGRFPEQFGPALERAMRAKLGLALEREGDAALANQLLEIMDASHADFTLTFRHLARVSKHDARGDAPVRDLFIDRDAFDRWANLYRARLSEEARDDASRAAAMNRVNPKYVLRNHLAETAIRRAKEKDFSEVERLAAVLRRPFDEQPEHDAYAALPPDWASTLEVSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL1</accession>
    <name>Q63VL1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522404.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107855.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1234"/>
    <dbReference type="EnsemblBacteria" id="CAH35228">
        <property type="protein sequence ID" value="CAH35228"/>
        <property type="gene ID" value="BPSL1234"/>
    </dbReference>
    <dbReference type="GeneID" id="56526628"/>
    <dbReference type="KEGG" id="bps:BPSL1234"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.292"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYREAPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="136"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="249"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="408" mass="45146" checksum="10CCD0E31316B24F" modified="2004-10-25" version="1">MHFDYSAKVEALRARLGAFFDEHIYPNERAFYEEIARNRRAGDAWRPVELIETLKAKARAAGLWNLFLPDSARGAGLTNLEYAPLCEIMGRVPWAPEVFNCNAPDTGNMETLERYGTDAHKAAWLEPLLDGVIRSAFLMTEPEVASSDATNIRTRIERDGEHYVINGHKWWSSGAGDPRCKLYIVMGKTDPDAPRHAQQSMMLVPSDAHGVTVHRPLNVFGYDDAPHGHMEITLENVRVPASNLLLGEGRGFEIAQGRLGPGRIHHCMRLVGLAERALELMCRRASERIAFGKPVAAQTVTQERIAEARCMIEQARLLTLKTAYMMDTVGNKGARGEIAMIKVVAPNMACQVIDWAIQAHGGGGVSDDFPLAYAYASARTLRFADGPDEVHRNAIAKLELARHAPRSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WA1</accession>
    <name>COBQ_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobQ</name>
        <name type="ordered locus">BPSL0987</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107615.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WA1"/>
    <dbReference type="SMR" id="Q63WA1"/>
    <dbReference type="STRING" id="272560.BPSL0987"/>
    <dbReference type="PRIDE" id="Q63WA1"/>
    <dbReference type="EnsemblBacteria" id="CAH34983">
        <property type="protein sequence ID" value="CAH34983"/>
        <property type="gene ID" value="BPSL0987"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0987"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.587"/>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EIHHGVA"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000141293" description="Cobyric acid synthase">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="GATase cobBQ-type" evidence="1">
        <location>
            <begin position="248"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <sequence length="486" mass="51293" checksum="025C7674403E4C7A" modified="2004-10-25" version="1">MIQGTTSDAGKSTLVAGLCRLARRTGARVAPFKPQNMALNSAVTANGGEIGRAQALQALAAGIEAHTDLNPVLLKPTGDRGAQVIIHGKARANLDARAYHDYKPTAMRAVLESYGRLRGAYDAVIVEGAGSPAEINLREGDIANMGFAEAVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVRGFVINRFRGDPALLEPGLRWLEARTGKPVLGVLPYLHGLTLDAEDMLPASARTSAARRDAGVLRIVVPALPRISNHTDFDALRAHPRVDFTYWRRGPVPDADLLILPGSKNVLADLAWLRDAGWDALIKRHLRYGGKVIGICGGMQMLGRTLADPHGVEGAAGATSAGLGLLDYATTLTPEKTLVNAAGRLAFGGDARVAGYEIHMGRTEGPALASPALMLAGRGGERPDGALSADGQILATYLHGLFDTPHACAALLEWAGLDGAEALDYPALREASLERLADTFAEHLDLDRVFAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WD8</accession>
    <name>Q63WD8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107578.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0949"/>
    <dbReference type="EnsemblBacteria" id="CAH34945">
        <property type="protein sequence ID" value="CAH34945"/>
        <property type="gene ID" value="BPSL0949"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0949"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1032"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="126" mass="14278" checksum="629B6AE0F702D9EF" modified="2004-10-25" version="1">MQPSCWPDIERYLFICRPTLLRAPTDLVFLTQKRGDKIGHVPWADLSKRVYELTGKYLPRCAGINAHAFRHLVATSILKADGGDYKTAALVLNDRTQTVEKHYAGLRSNDGAERMGTLLKSQFNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WG6</accession>
    <name>Q63WG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194783.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107550.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0922"/>
    <dbReference type="EnsemblBacteria" id="CAH34917">
        <property type="protein sequence ID" value="CAH34917"/>
        <property type="gene ID" value="BPSL0922"/>
    </dbReference>
    <dbReference type="GeneID" id="56595012"/>
    <dbReference type="KEGG" id="bps:BPSL0922"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.658"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSAFNCI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="257" mass="28332" checksum="1F50707C674DC146" modified="2004-10-25" version="1">MSEQIRLSVKGVNKRFGGLQALSDVGLEIREGQIYGLIGPNGAGKTTFFNVITGLYTPDSGEFKLDGTEYTPTAVHQVAKAGIARTFQNIRLFGGMTALENVMVGRHVRTKHGLLGAVFQTPAERREEREIKERAIELLDYVGVLQYADYTARNLSYGHQRRLEIARALATDPKLLALDEPAAGMNATEKVELTRLLDKIRSDGRTILLIEHDVKLVMGLCNRMTVLDYGKVIAEGLPQDVQKNPKVIEAYLGAGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WN6</accession>
    <name>Q63WN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ThiF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190050.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107480.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0855"/>
    <dbReference type="EnsemblBacteria" id="CAH34847">
        <property type="protein sequence ID" value="CAH34847"/>
        <property type="gene ID" value="BPSL0855"/>
    </dbReference>
    <dbReference type="GeneID" id="56596507"/>
    <dbReference type="KEGG" id="bps:BPSL0855"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.743"/>
    <dbReference type="eggNOG" id="COG1179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMDDICV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="34"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="288" mass="30225" checksum="3159B9CBDB997277" modified="2004-10-25" version="1">MSRTDAIATPHDVTPQPSGELDADRARRFGGVARLYGADALAAFERARVAVIGIGGVGSWAAEALARSAVGELTLIDLDNVAESNTNRQIHALDGNYGKPKVDAMAERIALIDPACRVVKIEDFVEPDNLDALLGGGFDYIVDAIDSVRTKVALIAWCVARAQPLVTVGGAGGQLDPTRIRIDDLAQTIQDPLLSKVRAQLRKQHGFPRGPKARFKVSAVYSDEPLIYPEAAVCDVDDVAMHTATDAQAPGPTGLNCAGFGSSVCVTASFGFAAAAHALRALAARAGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WX9</accession>
    <name>KPTA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kptA</name>
        <name type="ordered locus">BPSL0762</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204889.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107387.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WX9"/>
    <dbReference type="SMR" id="Q63WX9"/>
    <dbReference type="STRING" id="272560.BPSL0762"/>
    <dbReference type="EnsemblBacteria" id="CAH34754">
        <property type="protein sequence ID" value="CAH34754"/>
        <property type="gene ID" value="BPSL0762"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0762"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.847"/>
    <dbReference type="eggNOG" id="COG1859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLYHGTV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231951" description="Probable RNA 2'-phosphotransferase">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <sequence length="184" mass="20378" checksum="EC4D356963B8237B" modified="2004-10-25" version="1">MSSSYFIATRASKFLSYVLRHRPDSIGVTLDAQGWADVSELLTKAAAAGMALTLDELKQVVAENDKKRFVLNDDATRIRAAQGHSVDVDLQLPVKAPPPVLYHGTVGKSMADIRKQGLTPMNRHDVHLSPDRETATRVATRRGKPVILVIETYPLLRDGYQFRVSDNGVWLVPEVPAKYIKFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WZ2</accession>
    <name>Q63WZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL0747a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204876.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107374.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0747a"/>
    <dbReference type="EnsemblBacteria" id="CAH34740">
        <property type="protein sequence ID" value="CAH34740"/>
        <property type="gene ID" value="BPSL0747a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0747a"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="11739" checksum="006A9DCA6F26F289" modified="2004-10-25" version="1">MAKENRSCQRSPFALGFEHGAEAVEDAPLHEIESRVPEYRIGYVIGRTYSEAIRHVSLEAGFKLAGELGARFDIDKADLVSALQVSAGCRRLIDEGYVQAAGRGSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X22</accession>
    <name>Q63X22_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoribosyl transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526170.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107344.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0718"/>
    <dbReference type="EnsemblBacteria" id="CAH34710">
        <property type="protein sequence ID" value="CAH34710"/>
        <property type="gene ID" value="BPSL0718"/>
    </dbReference>
    <dbReference type="GeneID" id="56527075"/>
    <dbReference type="KEGG" id="bps:BPSL0718"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.894"/>
    <dbReference type="eggNOG" id="COG1926">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFYAVGQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="235" mass="25068" checksum="7DB9D7C900691DC2" modified="2004-10-25" version="1">MDDYFRDRVDAGRQLAAHLADYANRDDVVVLALPRGGVPVAFEVAKALRVTLDVLIVRKLGAPGNPELAMGAIATGGVVLLEQSVLRAMRVTERELADTIERERDELARREAAYRGDRAPPALDGRTVIVVDDGIATGSTMLAALEAVRAHRPARLVAAVPVASPSSVRKVEAAADATVCVMRPDGLMGIGQFYRNFEQTSDDEVRALLARAREWARPNAPDAPDAPPAAAGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X53</accession>
    <name>Q63X53_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526146.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107313.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0684"/>
    <dbReference type="EnsemblBacteria" id="CAH34677">
        <property type="protein sequence ID" value="CAH34677"/>
        <property type="gene ID" value="BPSL0684"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0684"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.934"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHRICAS"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="435" mass="46664" checksum="F40F42CEB0B672B9" modified="2004-10-25" version="1">MSHATVHPSGALKGTVTLPASKPHVQRALLVALLNGATTRIENVSWCAETELQFAALRQFGLTVVERGDASLTLRGAGAGVEATGTIDAAGSGMLFRMSAALASLSERPVTIRCNDSLFSRDSVFDDGFFSHLGIDARRRAGNLVTISRKAHPERIALTTRKSTQFISFALFVAPFSADRTLRVADDGSQAGYIDMTIKAMSLLHATVTRAPGRLLAGEYRADDIVIGIPTDFTSLSYLASAALSVGARSAIDIANYRPGDTLNEAALFDVYRALGVRLTRDDARHALRIECERDRAARRAPRELSLRELPSAATNIIAAASNLGDSIRFGGVDGINNHKCQRAFVIHENLRAMGGRSALVFNDVGRFDKIDVMSDGPLQGGAELPSYRDHRICAANIVAALGARRKTVVCDTDKLDDGFPKFIDTLRALGAEIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X78</accession>
    <name>SURA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone SurA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase SurA</fullName>
            <shortName evidence="1">PPIase SurA</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Rotamase SurA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">surA</name>
        <name type="ordered locus">BPSL0659</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <text evidence="1">Is capable of associating with the outer membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH34652" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34652.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550859.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107288.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63X78"/>
    <dbReference type="SMR" id="Q63X78"/>
    <dbReference type="STRING" id="272560.BPSL0659"/>
    <dbReference type="PRIDE" id="Q63X78"/>
    <dbReference type="EnsemblBacteria" id="CAH34652">
        <property type="protein sequence ID" value="CAH34652"/>
        <property type="gene ID" value="BPSL0659"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0659"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.961"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGGDMGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01183">
        <property type="entry name" value="Chaperone_SurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023034">
        <property type="entry name" value="PPIase_SurA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015391">
        <property type="entry name" value="SurA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09312">
        <property type="entry name" value="SurA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000270006" description="Chaperone SurA">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC 1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC 2" evidence="1">
        <location>
            <begin position="301"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="448" mass="48943" checksum="5FE0C8657B7EFBF1" modified="2007-01-09" version="2" precursor="true">MKKILRFAAVASGLVASLITVAPSASAQALRAQGASLADEVVAVVNNDVITGRELDQRVGLIARRLQQQKAPVPPTDQLRAQVLNQMVLERIQVQRAKDDGIVVDNATVQATLGRLAQANGMQLDQYKARIEAQGVPWDLFVRDARTELMLSKLREKEVDSKITVSDAEVASYIASQRGPNAGSQQDLRLEHIFVKAPANAPQADIDVAQKKAEGLLQQALASGANFERLAKNQSEADDAKKGGDLGFKSPASLPSDVVDAVSKLRPGEVNPTLIRVPDGFEIVRLVERRASQNPAASPKIVQTHVRHILLRVGEGKSESQARQQLIDIRRQIESGGDFEKFARTYSQDGSASQGGDLGWISPGETVPEFERAMNTLQDGQVSNPVRTEYGYHLIQVLGRRDAEGSVQQQMDIARQAIGQRKAEQAYSDWLRELRDSSYVQIKLPVAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X97</accession>
    <name>UBIB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable protein kinase UbiB</fullName>
            <ecNumber evidence="1">2.7.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ubiquinone biosynthesis protein UbiB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiB</name>
        <name type="ordered locus">BPSL0640</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; ubiquinone biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC1 family. UbiB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189815.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107269.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63X97"/>
    <dbReference type="SMR" id="Q63X97"/>
    <dbReference type="STRING" id="272560.BPSL0640"/>
    <dbReference type="PRIDE" id="Q63X97"/>
    <dbReference type="EnsemblBacteria" id="CAH34633">
        <property type="protein sequence ID" value="CAH34633"/>
        <property type="gene ID" value="BPSL0640"/>
    </dbReference>
    <dbReference type="GeneID" id="56596665"/>
    <dbReference type="KEGG" id="bps:BPSL0640"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.983"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RRDYKRV"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010795">
        <property type="term" value="P:regulation of ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13972">
        <property type="entry name" value="UbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00414">
        <property type="entry name" value="UbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010232">
        <property type="entry name" value="UbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045308">
        <property type="entry name" value="UbiB_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01982">
        <property type="entry name" value="UbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="chain" id="PRO_0000200701" description="Probable protein kinase UbiB">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00414"/>
        </source>
    </evidence>
    <sequence length="525" mass="59775" checksum="4A181EFE29BC5F5B" modified="2004-10-25" version="1">MRIFRFVKIVFTVIRFGLDEVMLSRIENPRVKLLLRITTIGRRFADPPAVRLRRALESLGPIFVKFGQVLSTRRDLLPVDFANELAKLQDQVPPFDSAVAIAIVEKSLGARIDVLFDEFERVPVASASIAQVHFAKLKQGEHKGKAVAVKVLRPNMLPVIDSDLALMRDIATWAERLWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDYSTPAVLVMERMTGVPISQVDTLRAAGVDIPKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPKHFGRYIALDFGIVGALSDFDKNYLAQNFLAFFKRDYHRVATLHLESGWVPPDTRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLVLLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTLPQLPRLVHQALISHHEAPRAISDDLIRQILVEQRRTNRLLQALLVFGLAVGAGAVIARVLIVLAYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XJ2</accession>
    <name>Q63XJ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107173.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0548"/>
    <dbReference type="EnsemblBacteria" id="CAH34537">
        <property type="protein sequence ID" value="CAH34537"/>
        <property type="gene ID" value="BPSL0548"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0548"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.612"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIAHANA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1344" mass="147153" checksum="509340D97BFA837E" modified="2004-10-25" version="1">MVSEERRSIYMRTFTLEIVKPKHAEDFEDYCAEIYSVVFEDPTPKRNGRTGQSQGGVDIFVEPRVGKRKGIQCKRYYETKVTEKVIADEVVAADKAGWSIGELIVATTAASDSKLVKYAQDLTDARAESGKFKVSIEFWDDICNHIKRHAILQKKYSPNSPGGVYDDIRTSSEKTHSTVVETNELVSALSSKLDSLMTQVGGHAFVSSLVTNENNTVSRQLDKVAEFIKEMSYSGASALLSVIFDEFSSLNERQKARWYLLSGIVDWHAGDVSGAVQKFDTAYETYPDDDRVASGKVRGLLLSDHLDDAFDIAERARSRFPDSAHVWLAWANTKIALKQFLAEADLPRKFEGNADALQMMAISFHDAGNRALSLTYADRALHADGAGFYTWTNVLFIATDFASKDPFLASMGLLPPEVARTLQAVCECFEPRDERLWRKEIGPLVSDAAANLAVGRLLLGDALACLKICEEAGVFGESALKLAAPRVYAYHELGDLKKVVEVGAPHLKDMHISAQMMVGESAAILGMPELVRDIAESNAVATDSDAAKTAQALMWIALRNSGDSSSATDLLDKHDFKVETAPILLNAAARIYLAVGQQEKAAMLGGKIAALVTTASAQPVKIQAADTLTALGNYKAAISLLTSVPNANLSRGLQTRLLEAYAKGGYRAKARSIVDSAPPDWFEDDAFVGMAILAAQQANDWHRLKPLALRQRDRCPTDARAWEFWYRVALQTLRPGEIRRAFGEAPLELSGDPKVIRRVALAEIQYGDRDLGMRRLYRLFRCNLDNANAAAGFITALLTADDIPWGAAPTAVSAGVAATLLREDGSPFTIVVDPADVGNLPQAQNYFPHDSGFAANFMGKGVGDVVTIRHQLGEETTYRVASLMPALRYLLGYAHELTENSVEPIPGFRTISFKNDDGGIDMSRIHSQLKRWSGAADVVIDGYRQGRLTVGLCAQLLGRSPVDIILSWGPSQPPLVVAEGRVTGGPERSNPPGSSSSCVLDCITLVELGLFKALSVLGLLPHPVVSQRAYDLLLIALDEAKDERSIGRAREIDGELAIVRYGPEDRQQRVAMLTSIIESVQRYCEVAPAYGPAEVPNNFLEFKGVLDDESYDAIALCLEKRAELVSIDARLRALALSGFEVSSVSPQAVIAHATQTGQLPLAEHRQYLMLSLLSNRTYISIASYDFLWMLSQAGYSSIVLDAWAEVIASSNTWFDSAVRVVCGVFRSLHLLDVQFGALACVVERLASAIYRHPAFRSVADEAMREALQHTVEEVYEAAPWHPTLTAALRQRADELSEFIAASLFRAKEVAEGKTAPTKHSLRSLYCLCRPILFEKQEALPNVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XJ4</accession>
    <name>Q63XJ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195190.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107171.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0546"/>
    <dbReference type="EnsemblBacteria" id="CAH34535">
        <property type="protein sequence ID" value="CAH34535"/>
        <property type="gene ID" value="BPSL0546"/>
    </dbReference>
    <dbReference type="GeneID" id="56593787"/>
    <dbReference type="KEGG" id="bps:BPSL0546"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.610"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYADSFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="395" mass="41169" checksum="9D92127FDF743D5A" modified="2004-10-25" version="1">MSNPSATSTRMSAPELRATTSLAAIFALRMLGLFMIMPVFSVYAKTIPGGENVVLVGIALGAYGVTQSLLYIFYGWASDKFGRKPVIAAGLLIFALGSFVAAFAHDITWIIVGRVIQGMGAVSSAVLAFIADLTSEHNRTKAMAMVGGSIGMSFAVAIVGAPIVFHWVGMSGLFAIVGALSVAAIGVVLWVVPDAPRPVHVPAPFAEVLHNVELLRLNFGVLVLHATQTALFLVVPRLLVDGGLPVASHWQVYLPVMGLAFVMMVPAIIVAEKQGRMKPVLLGGIAAILIGQLLLGVATHTILIVAAILFVYFLGFNILEASQPSLVSKLAPGSRKGAATGVYNTTQSIGLALGGVVGGVLLKHGGPDTVFFACSALVAVWLIIAAGMKQPPRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XK4</accession>
    <name>Q63XK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522855.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107161.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0536"/>
    <dbReference type="EnsemblBacteria" id="CAH34525">
        <property type="protein sequence ID" value="CAH34525"/>
        <property type="gene ID" value="BPSL0536"/>
    </dbReference>
    <dbReference type="GeneID" id="56527218"/>
    <dbReference type="KEGG" id="bps:BPSL0536"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1112"/>
    <dbReference type="eggNOG" id="COG3117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VAGSTFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="204" mass="21690" checksum="1BAFCCF02B832728" modified="2004-10-25" version="1">MDGKFRLTSMIPLAAMAALAGGTYWLLQATLPPPGEAVVRPKSHTPDYFADNFSVTELDQTGSTQYRLTAAGLVHYEDDETSDLTRPALRAFQPGKPTVTATAKRGAVNGDVSIVDLYDDARILRAAGAGDPPMQADSQHFRVLVNDDVIETEKPVKLQRGLSIANAAAGMKYNNVTRVIELYGNVRGTIAASDTSGGAAGQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XS1</accession>
    <name>Q63XS1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative branched-chain amino acid transport system / permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195284.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107094.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0468"/>
    <dbReference type="EnsemblBacteria" id="CAH34457">
        <property type="protein sequence ID" value="CAH34457"/>
        <property type="gene ID" value="BPSL0468"/>
    </dbReference>
    <dbReference type="GeneID" id="56593833"/>
    <dbReference type="KEGG" id="bps:BPSL0468"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1187"/>
    <dbReference type="eggNOG" id="COG4120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RHILIHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="31120" checksum="8291E2B8EB189BF2" modified="2004-10-25" version="1">MSLFSLLGALEIGLIFSLVALGVLISFRILNFPDLTVDGSFPLGGAVAATLIAAGHDPFTSTLAAIAAGACAGFVTGWLNVRLKIMDLLASILMMIALYSVNLRIMGRPNVPLITEPTLFTVLQPDWMPDYVLRPALLAVVVVCAKLGLDWFFSSQLGLAMRATGANPRMARAQGIPTGRATLAGMALSNALVALAGALFAQTQGGSDISMGIGTIVIGLAAVIIGETLLPARRLFLTTLAVVLGAILYRFFIALALNSEFVGLKAQDLNLVTALLVTVALVLPATRKKLFGRKTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XV4</accession>
    <name>Q63XV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="1">6.3.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gshA</name>
        <name evidence="1" type="ordered locus">BPSL0436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107061.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0436"/>
    <dbReference type="EnsemblBacteria" id="CAH34424">
        <property type="protein sequence ID" value="CAH34424"/>
        <property type="gene ID" value="BPSL0436"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0436"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.490"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMHFVPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011718">
        <property type="entry name" value="GshA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042520">
        <property type="entry name" value="GshA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08886">
        <property type="entry name" value="GshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02049">
        <property type="entry name" value="gshA_ferroox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="442" mass="48909" checksum="B8F24C70423FFE19" modified="2004-10-25" version="1">MLYNLFSPVRESHMVPHLVTALNGPLLELERKILDATPAIERWFRLEWQEHTPPFYCSVDLRNAGFKLAPVDANLFPGAFNNLPPEVLPLAVQAAMAAIEKICPDAKNLLVIPELPTRNAFYLENVARLATIMRQAGLNVRFGSLDPSIAEVTPITLADGQKIVLEPLERTPRRLGLKNFDPCSILLNNDLSAGIPSVLENLHEQYLLPPLHAGWAVRRKSTHFSCYDDVAKKFAKMVGVDPWMLNPYFSPVEGVDWHASDGGEALAEAIDAVLKKIARKYREYGIGEKPYVVVKADAGTAGRGVMTVHDASEIGRMTKHERAQMAESKAGVPVSDVIVQEGVYTFERIGDEVAEPVVYMIDRYVVGGFYRTHGARERDQNLNAPGMHYVPLGFEHTALPDTHAKPGAAPPNRFYMYGVVARLGLLASSVELEKTDPEAIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y40</accession>
    <name>Q63Y40_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106975.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63Y40"/>
    <dbReference type="STRING" id="272560.BPSL0348"/>
    <dbReference type="EnsemblBacteria" id="CAH34337">
        <property type="protein sequence ID" value="CAH34337"/>
        <property type="gene ID" value="BPSL0348"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0348"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.388"/>
    <dbReference type="OMA" id="GILYDIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038712">
        <property type="entry name" value="PixA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021087">
        <property type="entry name" value="Uncharacterised_PixA/AidA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12306">
        <property type="entry name" value="PixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="257" mass="27887" checksum="3B66116E6A87947D" modified="2004-10-25" version="1">MSFGYEGLRRPILSRSTRPRATTAVRAQHPSRQQSTLPIPVGVPSARTAHHAYEASIAYMSRHFTKAIFMEPSATTTPPRHRVDLLVVIDSDYVKENYPDGSRVPGTPTPVDSRALFVICAGSDIGDIQSGEAICTAAVGDVVSVTCTTIQDNSSDAGILYDIWQAVNGQVFTPFKQNFSELTGAVQPDPESESRDGLPPLRKEAHVSNFTADVKSLGNAQLGLAFGIYTLARDGQRQDLLGYYLSPVVLQVRGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y44</accession>
    <name>Q63Y44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106971.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0344"/>
    <dbReference type="EnsemblBacteria" id="CAH34333">
        <property type="protein sequence ID" value="CAH34333"/>
        <property type="gene ID" value="BPSL0344"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0344"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.384"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMDVLMW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266663" evidence="3">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="33"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="197" mass="21718" checksum="5617B5DBFF20F4DC" modified="2004-10-25" version="1">MMRRKALGALCSLALAGAPVGSRAATPFYSLPLSSKDWHKGFRLTDLHGHTKTPQDYRGNVLLLFFGFLSCPSICSTTMLELTQAKERVGAQKDKVKILFVTLDPNRDTSPTIARWLASFGDDNIGLRDSEAHVRKAATALNLKYERVEGDVPGAYTIDHGVQTYVFDPQGRLRLIARAGIEPEYVAKDIVQLLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC6</accession>
    <name>Q63YC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525894.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106889.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0262"/>
    <dbReference type="EnsemblBacteria" id="CAH34250">
        <property type="protein sequence ID" value="CAH34250"/>
        <property type="gene ID" value="BPSL0262"/>
    </dbReference>
    <dbReference type="GeneID" id="56527495"/>
    <dbReference type="KEGG" id="bps:BPSL0262"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1446"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RQESAFM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012289">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14718">
        <property type="entry name" value="SLT_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266863" evidence="2">
        <location>
            <begin position="30"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_L" evidence="4">
        <location>
            <begin position="415"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="492"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="651" mass="72424" checksum="384CDAC30EF8E31A" modified="2004-10-25" version="1">MSTSLFRVYRAVAAPLVAIALAAVAAACAAQTADEASSNDDRVFVQLREAARRNDPVRAAQLAALIPNYPAPSYLEYFQIKPQLFDSAGHARLDAPDAPVLSFLSRYDGQAIADRMRNDYLLVLGARHDWRAFDEQYKRFVLDDDTQVKCYALESRASRGENVADMARELLVEPKYYGDACVDLITALATNKQFSSDDVWAQVRLAYEQNYTTLGGKIADALGPRPVGFDQVTSAPPLFLARGVGSDATSRQLALVAITRMARNDPEAAAGQLASLASTLSAAEQAIGWGEIGYQATVKRLPQAASWYRKSMDAPLSNPAYEWRVRAALLAGDWPMVRRSIEQMPERLRDDTAWIYWRGRALKESGDTLKANQEFERIAGQFNFYGQLAGEELGQKTTIPPRTKVTDAEIDAMSKVPGFALAQRFYALNLRLEGNREWNWPLRGMTDRQLLAAAEYGKRVDLLDRTVNTADRTTAEHDFSLRYPSPYRDIVERYARTNGLDVEWAYGLIRQESRFITNARSTVGAGGLMQLMPATAQLVAKKLGLGTVSRAQMHDIDTNVQLGTWYLSDIYQKFDDSAVLATAGYNAGPGRPAQWRQVLTRPVEGAIFAETIPFNETREYVKNVLSNETYYAALFEKKPQSLKARLGFIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YN4</accession>
    <name>Q63YN4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941339.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106781.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0153"/>
    <dbReference type="EnsemblBacteria" id="CAH34140">
        <property type="protein sequence ID" value="CAH34140"/>
        <property type="gene ID" value="BPSL0153"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0153"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1568"/>
    <dbReference type="eggNOG" id="COG4385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIRIKEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01634">
        <property type="entry name" value="tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="184" mass="20250" checksum="59C09A777D6078B2" modified="2004-10-25" version="1">MTRRATSLLPPNATALERRLADTNARISDIPVDIGALMDPDAIPLRFLPWLAWHLGVETWKDYWPEQVKRARVKAAIRIARKKGTAAAVREVCASFGANVAMREWFEKTPKGRPGTFEILMTVGARDGIPATAEYVADIIAEVDRAKRGTAHYTFTQGFGATGTQRIGAGARAAVYRRLSLTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS6</accession>
    <name>Q63YS6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2778 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200731.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106739.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0113"/>
    <dbReference type="EnsemblBacteria" id="CAH34098">
        <property type="protein sequence ID" value="CAH34098"/>
        <property type="gene ID" value="BPSL0113"/>
    </dbReference>
    <dbReference type="GeneID" id="56596721"/>
    <dbReference type="KEGG" id="bps:BPSL0113"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1614"/>
    <dbReference type="eggNOG" id="ENOG5032SJM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPVECTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021225">
        <property type="entry name" value="Tlde1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10908">
        <property type="entry name" value="DUF2778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2778" evidence="1">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17604" checksum="BC056C20F1806C0B" modified="2004-10-25" version="1">MPAECTFVLNRSRLSTLTCPGFGSVPAFSGNGRYINDPGSTAVADKGPLPAGVYYIIDRQSGGHLGWFRDTVMDAALNTYRAEWFALYRIDGQIDDWTIVNGIRRGHFRLHPVGRLGESDGCITLTSRGQFDKLRAFLKAQPTTQVPGTSFRAYGKVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z12</accession>
    <name>Q63Z12_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196788.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106650.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0025"/>
    <dbReference type="EnsemblBacteria" id="CAH34008">
        <property type="protein sequence ID" value="CAH34008"/>
        <property type="gene ID" value="BPSL0025"/>
    </dbReference>
    <dbReference type="GeneID" id="56594164"/>
    <dbReference type="KEGG" id="bps:BPSL0025"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1722"/>
    <dbReference type="eggNOG" id="COG1346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLHTAYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="25622" checksum="1D0CCAFA1CBE471C" modified="2004-10-25" version="1">MTTPDLSFLTAPSSAAISAGCFALTIALYFASKRLYACRKTLFFSPLVLVPAVLVAFVALTGIPYAVYFRDTRWLMWLLGPATIAFAVPIYEYRELMKRHWFSLAVGVVVGIAVAICGSLLLSKLLHLSPELQRSLVTRSVSTPFALAVSDRIHAPRDLTALFVIATGICGMLVGEFVLALVPLRSRLARGALFGAAAHAVGTAKAREIGSEEGVVSSLTMMIAGVAMVLIAPLLTLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>H7C7G3</accession>
    <name>H7C7G3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliC</name>
        <name evidence="7" type="ordered locus">BPSL3319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198207.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109915.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="H7C7G3"/>
    <dbReference type="STRING" id="272560.BPSL3319"/>
    <dbReference type="EnsemblBacteria" id="CAH37332">
        <property type="protein sequence ID" value="CAH37332"/>
        <property type="gene ID" value="BPSL3319"/>
    </dbReference>
    <dbReference type="GeneID" id="56593974"/>
    <dbReference type="KEGG" id="bps:BPSL3319"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1895"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IASQTTY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022578">
        <property type="entry name" value="Flagellin_DUF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12613">
        <property type="entry name" value="FliC_SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FliC_SP" evidence="6">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="304"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="39256" checksum="0265EA50F40084DE" modified="2012-04-18" version="1">MLGINSNINSLVAQQNLNGSQGALSQAITRLSSGKRINSAADDAAGLAIATRMQTQINGLNQGVSNANDGVSILQTASSGLTSLTNSLQRIRQLAVQASNGPLSASDASALQQEVAQQISEVNRIASQTNYNGKNILDGSAGTLSFQVGANVGQTVSVDLTQSMSAAKIGGGMVQTGQTLGTIKVAIDSSGAAWSSGSTGQETTQINVVSDGKGGFTFTDQNNQALSSTAVTAVFGSSTAGTGTAASPSFQTLALSTSATSALSATDQANATAMVAQINAVNKPQTVSNLDISTQTGAYQAMVSIDNALATVNNLQATLGAAQNRFTAIATTQQAGSNNLAQAQSQIQSADFAQETANLSRAQVLQQAGISVLAQANSLPQQVLKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-10-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V7S5</accession>
    <name>Q3V7S5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyochelin biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pchG</name>
        <name evidence="3" type="ordered locus">BPSS0588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535061.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110609.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0588"/>
    <dbReference type="EnsemblBacteria" id="CAH38045">
        <property type="protein sequence ID" value="CAH38045"/>
        <property type="gene ID" value="BPSS0588"/>
    </dbReference>
    <dbReference type="GeneID" id="56530960"/>
    <dbReference type="KEGG" id="bps:BPSS0588"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6764"/>
    <dbReference type="eggNOG" id="COG4693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CATHYAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010091">
        <property type="entry name" value="Thiazolinyl_imide_reductase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017494">
        <property type="entry name" value="Thiaz_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01761">
        <property type="entry name" value="thiaz-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="37094" checksum="120A1D061E722A50" modified="2005-10-11" version="1">MSTHPLPVVVAGSRFGQFYAAGLAASGAYRIAGILGQGSARTAALARRVGAPVFTDPGALPDDVRIACVAVGGAARGAQGAALARGLLERGIDVLIEHPLLPAEWDAVLRTAARHGRRCLLNSFYPHLPAVARFVDVAQRLSRIGRPLHVDLACSVQASYAALDVLASALRGVGPWSIEPARQASSPMRECTMVLAQTPVALRVHNEMAAAADGRMHLLFRIALMTAHGTWTLASPHGPLAWEPALREPPADDDGLFPIFGAAAPPHGLPSMQLYEAEPPAWDAIHARHWPRAAVRAVDRLASGDGLAASNQRSVEVTRVWQHLTAQLGFPEPPPGDASADTLEPLLERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV0</accession>
    <name>Q63HV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552295.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112322.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2320"/>
    <dbReference type="EnsemblBacteria" id="CAH39806">
        <property type="protein sequence ID" value="CAH39806"/>
        <property type="gene ID" value="BPSS2320"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2320"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6778"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTIFEQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="135"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="254" mass="28009" checksum="B667BAE1AD6F3BA7" modified="2004-10-25" version="1">MMVEGLPRATPRAAGATLAFSVARPSAALMARLMRGEVHVWRARAEEAGSYLKRDCLSLSEHERAARLRYGAHRELFVFARAMLRIVLGEYLSADPARLVFDVEPGGKPVLFGRDLEFSVSHASGAVLLALARKRVGCDLESLGRKLDIDALAAASLGERERDVFARTPRRAQARLLLQCWTRKEALLKAHGAGLRRDPRELEMPWPARRAARDECACGDVRWAVADIALGTGWRAAVAMEERGADVHGFCLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HW7</accession>
    <name>Q63HW7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529512.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112305.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39788">
        <property type="protein sequence ID" value="CAH39788"/>
        <property type="gene ID" value="BPSS2302"/>
    </dbReference>
    <dbReference type="GeneID" id="56531607"/>
    <dbReference type="KEGG" id="bps:BPSS2302"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6753"/>
    <dbReference type="eggNOG" id="COG0726">
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    <dbReference type="OMA" id="AYPFGLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
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        <property type="entry name" value="NODB_dom"/>
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    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267203" evidence="1">
        <location>
            <begin position="32"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="106"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="32520" checksum="D26E1604530F38F4" modified="2004-10-25" version="1">MRHSGSRLTRFRLAAAACCLALASAARPAFAGANAPAAAEPPTDAQRPAILVYHRFSTSAPPDSMTVRVSTFGAQLAFLRAHGYTFVPLRDVVAWAASPSAPLPDKAIAITVDDGHRSVYELLRPIVLRERLPVTLFIYPSAISNASYAMTWDELRALRATGRFDIESHTWWHPNFRTERRRLAPDAFRRFAATQFAHSRARLEREIGGPVDLLAWPFGLYDDELTSLAAQAGYVAGFTLDARKVRRGDAPLALPRLLIVDSCTPAVLARMLGERGDARADSHADLHVDSHAEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ5</accession>
    <name>Q63HZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196898.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112277.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2274"/>
    <dbReference type="EnsemblBacteria" id="CAH39760">
        <property type="protein sequence ID" value="CAH39760"/>
        <property type="gene ID" value="BPSS2274"/>
    </dbReference>
    <dbReference type="GeneID" id="56598384"/>
    <dbReference type="KEGG" id="bps:BPSS2274"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5888"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHRGVMK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="16848" checksum="1E4C2DECB9CFC625" modified="2004-10-25" version="1">MKQQRIEIAEEFDAPVHQVFRFFSEHENLKSIFSPAKIRRISDGEPARNGVGSAREMRVPGAPPFVETVTAYQENELIEYRITRGSPLRDHLGVMRFVPIDERRTYFHYVITFEGKVPFVAPVVRHVLEGSIRRGLGKVATRRLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I98</accession>
    <name>Q63I98_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS2172a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523392.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112174.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2172a"/>
    <dbReference type="EnsemblBacteria" id="CAH39657">
        <property type="protein sequence ID" value="CAH39657"/>
        <property type="gene ID" value="BPSS2172a"/>
    </dbReference>
    <dbReference type="GeneID" id="56531739"/>
    <dbReference type="KEGG" id="bps:BPSS2172a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5751"/>
    <dbReference type="eggNOG" id="COG2879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KGGPKCC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38453">
        <property type="entry name" value="PTHR38453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="68" mass="7764" checksum="6E1E4703853D7719" modified="2004-10-25" version="1">MFSDLGGEWRTAGRYLGQALRLMVGLPDYDGYVAHMRATHPDRPVMTYEEFFRERQNARYGSGAGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ7</accession>
    <name>Q63IJ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase / muconate lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-04" db="PDB data bank">
            <title>Crystal Structure of a Member of Enolase Superfamily from Burkholderia Pseudomallei.</title>
            <authorList>
                <person name="Patskovsky Y."/>
                <person name="Bonanno J."/>
                <person name="Sauder J.M."/>
                <person name="Gilmore J.M."/>
                <person name="Iizuka M."/>
                <person name="Gheyi M."/>
                <person name="Ozyurt S."/>
                <person name="Wasserman S.R."/>
                <person name="Smith D."/>
                <person name="Gerlt J."/>
                <person name="Burley S.K."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.34 ANGSTROMS) OF 2-400</scope>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524840.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112075.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="2POD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.34 A"/>
        <property type="chains" value="A/B=2-400"/>
    </dbReference>
    <dbReference type="PDBsum" id="2POD"/>
    <dbReference type="SMR" id="Q63IJ7"/>
    <dbReference type="STRING" id="272560.BPSS2072"/>
    <dbReference type="EnsemblBacteria" id="CAH39552">
        <property type="protein sequence ID" value="CAH39552"/>
        <property type="gene ID" value="BPSS2072"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2072"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5617"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAEAWHL"/>
    <dbReference type="EvolutionaryTrace" id="Q63IJ7"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="155"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2POD"/>
        </source>
    </evidence>
    <sequence length="400" mass="44516" checksum="4318CB447FE34713" modified="2004-10-25" version="1">MKITEIETLRPEEFPNLLWVLVHTDEGITGLGETFYGACSAEAYIHEWAANRLIGEDPLQIDRHAKRLSGYLGFRSAGAEMRGNSALDIALWDIFGKATGQPIYQLLGGKCRDTIRTYNTCAGPHYVRTAKQQSVANWGLANSVSARYDDLNAFLHRADELALDLLDSGITAMKIWPFDPYAEASDGYYISKSDLKRALEPFEKIRRAVGDKMDVMVEFHSLWNLPPALQIAEALREYETFWHEDPIRMDSLSSLKRYAERSLAPVCASETLATRWGFRDLLETNAAGIVMLDISWCGGLSEARKIASMAEAWHLPVAPHDCTGPVVLTASTHLSLNAPNALVQESVRAFYDGWYRDLVTALPTVKDGHITVPDGPGLGLELMPDIRERLTIAVRNTSDC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX0</accession>
    <name>ATPA2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha 2</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA2</name>
        <name type="ordered locus">BPSS1946</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205710.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111952.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63IX0"/>
    <dbReference type="SMR" id="Q63IX0"/>
    <dbReference type="STRING" id="272560.BPSS1946"/>
    <dbReference type="EnsemblBacteria" id="CAH39424">
        <property type="protein sequence ID" value="CAH39424"/>
        <property type="gene ID" value="BPSS1946"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1946"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5436"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VICIYCA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000238220" description="ATP synthase subunit alpha 2">
        <location>
            <begin position="1"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="666" mass="69788" checksum="ACE4F3CFA1E4193E" modified="2004-10-25" version="1">MTPTPDAPAAAAADAATGAGWLARRRGALARVALAPVAQAIGRVERVADGIAFVSGLEDTMLNEVLRFEGGVTGFAHTLDEDLISVVLLDPDAGVRAQTAVARTGAVLEVPAGPQLLGRVVDPLGRPLDGGAPLDAAHTLPIERAAPAIIERDLVSEPLDTGVLIVDALFTIGRGQRELIIGDRATGKTSLAIDAIVNQRHSDVICVYVAIGQRASAVRRVIDAVRRYGAPERCVFVVAPAACAPGLQWIAPFAGFSIAEYFRDRGQHALVVVDDLTKHAATHRELALLTREPPGREAYPGDIFYVHARLLERAAKLSAALGGGSLSALPIAETDAGNLAAYIPTNLISITDGQIVLDSALFAANQRPAVDVGLSVSRVGGKAQHPALRAASGRLRLDYAQFLELEAFTRFGGLTDARLRAQITRGERIRALITQPRFRALRTLDEVVLLKALAAGALDAMSPDLVAPLRERLPAWLDARIAALTPALAPPRDWLADDAALDALAESVGELIERIAADAARRATAGMPAEDAAGDIGGAFGGEQARGDADRDADHGANREVSREVSPEASREVSREVSCEVSHEADRDAAADAARVAGRAPGRAEPDRAAPRAMPDGPPRAQADGDRASASRPRPDARGDAARTAPSPQGGADANVDAEAEARHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX5</accession>
    <name>Q63IX5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative methyl-accepting chemotaxis transducer transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524990.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111947.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1941"/>
    <dbReference type="EnsemblBacteria" id="CAH39419">
        <property type="protein sequence ID" value="CAH39419"/>
        <property type="gene ID" value="BPSS1941"/>
    </dbReference>
    <dbReference type="GeneID" id="56529640"/>
    <dbReference type="KEGG" id="bps:BPSS1941"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5429"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDVNYVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17200">
        <property type="entry name" value="sCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="272"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="521" mass="55667" checksum="3FB42B3CA616799E" modified="2004-10-25" version="1">MPTLSFRQKLWLPLVISLIALLLVSISSAWLSYQTRMEERRNDLTNVAHVGLSIVREYAALAQRGVLTDAQARKEALERLRSVRYGSDGYFIVIDSSPRMIMHPIKPDTVGKDLRHVADADGRHHYLTFASVAQSPQGGFVDYVFAHPNAHPAKAVDKLGYVIRYAPWDWIISTGAYIDDIQAAFAKSLCLSAGVFALLAALLALSVVYTNRGIERMIGGDPRIAAHMAGVIASGDLATPFATRREDRSSLMFAISQMRDALANAVAQIRASAGYVATTAGEIADSNMDLSSHTECQATALQQAASSMQRLTERVRDTADRARAASELAGSAARITDRGGDMVVRVVAAMNDIRAESRKMVDIIGVIEGIAFQTNILALNAAVEAARAGNEGRGFAVVASEVRVLAQRSASAAKDIRALIGRAAERVGNGAELVEATGATIGEAQHAICRVTGIVQDIAAAATDQSQGLEQINAAVSQMDSVTRRNATLVEHAAIAAQSLNEQSRCLQDAVAAFRTEALGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX8</accession>
    <name>Q63IX8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BPSS1938</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205708.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111944.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1938"/>
    <dbReference type="EnsemblBacteria" id="CAH39416">
        <property type="protein sequence ID" value="CAH39416"/>
        <property type="gene ID" value="BPSS1938"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1938"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5425"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FTENFTD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="272"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="514"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="611"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="304"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH39416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1074" mass="114963" checksum="959694272DE0461F" modified="2004-10-25" version="1">MSAPSVVRFSDVSLRYGKTVALERITLEIPAGLTIGLIGPDGVGKSSLLALAAGARALQTGAVDALGGDMRSRRHRERVCRRIAYMPQGLGKNLYPTLSVEENLQFFARLFGHDADERRRRIDALTRSTGLFAFLSRPAGKLSGGMKQKLGLCCALIHDPDLLILDEPTTGVDPLARAQFWDLIARIRSERPAMSVIVATAYMDEAQRFDWLIAMDAGRVLATGAPAELLARTGCDSLEAAFIALLPEDERRGHKPVTLEPLRADAQTGTAIEARGLTMRFGDFTAVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPATEGTAQLFGKTVDPKDINTRRRVGYMSQAFSLYSELTVRQNLVLHARLFGVPAAEIDARVDEMARRFGLADIYDMLPDSLPLGMRQRLSLAVAMVHKPELLILDEPTSGVDPVARDSFWQLMIDLARRDRVTIFISTHFMNEAQRCDRISLMHAGRVLASDAPAALVRARGAATLEEAFIGYLVDASAQEAQGGAGGRPGAGERAAGESLAGRGAATDGDADGAHARPAAYANGAAQHRAPDADAAGTDVAAETGARDDARTAHAAGHSAGNDVRATVGSEVGSEVASEAGLAASAESGSERGVAHGAERAREPAADAGAAIDVEPGASAESATAAVAPARHAESAATSPRAGNAPAGTPFAAAPPSHAAPAEPPHRAFSAQRALSYMWREMLELRRDPVRATLALIGSLVLMCVIGIGISLDVEDLTYAVLDRDQTELSHDYALNLSGSRYFVERPPIADYAALDRRMRDGELSLAIEIPPNFARDVERGAPAQIGMWIDGAMPQRAETIRGYAIGMHTMWLADKARHRLGVTLAPRAEVVTRYRYNPDVKSLPAMIPAVMPLLLLMLPAMLTALAVVRERELGSILNLYVTPVTRTEFLIGKQVPYVVLAMLNFLLMTMLARIAFDVPVKGSFMTLLLAVLIFNVVATGIGLLASTFTRSQVAAIVMTIIGTMIPTVQFAGLLTPLSSLEGTGRLIGLVYPATYMLSISRGVFNKALSLHDLYSQFWPLAASVPVILGATILLLKKQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J31</accession>
    <name>Q63J31_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aromatic hydrocarbons catabolism-related reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556319.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111891.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1885"/>
    <dbReference type="EnsemblBacteria" id="CAH39363">
        <property type="protein sequence ID" value="CAH39363"/>
        <property type="gene ID" value="BPSS1885"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1885"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5351"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IATYPYH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="323"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="413" mass="43900" checksum="55B81DBE7CB761B4" modified="2004-10-25" version="1">MSTADPYLIAGGGHAARRAAETLRERDAAARIVMIGAEPELPYDRPVLSKEALVGGDAGERRAFVRDAAWYRERDIELRLGVRVEAIERGARRVRLSDGARLGYARLLIATGSRVRRFAGPVDAGVHVHYVRTLADTRALRAALAPGKRVAVLGGGFIGLEVAASAVRLGCRATVVDPAPRLLQRGMPEAVGAFALALHARHGVDVRLGALPERIRRAANGSAVVETSAGGIVADVVVAGIGVVPNVELAQAAGLDVDDGVCVDEMCRTTDPAIFAAGEVTRHFNPLVGRALRIESWQIAENQPAVAAANMLGAAETYAQWPWLWSDQYDCNLQTLGLFGGEQTLVLRGSPERDRAFCVFALNARRELAAVAAVNAGREIAVCRRLMTAGVALDPARLADPSDALRAMLPRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J34</accession>
    <name>Q63J34_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111888.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1882"/>
    <dbReference type="EnsemblBacteria" id="CAH39360">
        <property type="protein sequence ID" value="CAH39360"/>
        <property type="gene ID" value="BPSS1882"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1882"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6227"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRGVPWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="141" mass="14427" checksum="A6EDF6219C93EB79" modified="2004-10-25" version="1">MFGTTRDTQAGLRLAAFVQRLDGAIAFGAYVGGALAGMAGFKRPDGAKGRHRGVPWGMFVAPAARRPGVGAALLDAALAAAARTAGQVALAAVDSRGAARAFCERHGFVAYGVEPRALDAANGRADDLPMVRFPPLAPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J66</accession>
    <name>Q63J66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111856.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1852"/>
    <dbReference type="EnsemblBacteria" id="CAH39328">
        <property type="protein sequence ID" value="CAH39328"/>
        <property type="gene ID" value="BPSS1852"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1852"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5304"/>
    <dbReference type="eggNOG" id="COG2130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECPKGVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="36042" checksum="E32FB1A6B32FABB8" modified="2004-10-25" version="1">MSTPVNRQLRLKARPDGRVGHEHFTLAEAPLPPLGPGEMLVRVLYLSMDPTNRVWMSDIPQYLPPVAIGDVMRALGIGRVVASNAPGFAEGDLVQGLVGWQDYAHVRADEIAQYTKLPAALGLPLPRLLGACGMSGLTAYYGLTEIAPVQPGETLVVSAAAGSVGSVAGQIGKIHGTRVVGIAGGADKCRYLTDELGFDAAVDYKSDDWKRALKDATPDGVHVSFENVGGEIMRAVLSRMAIGGRVALCGVIANYNSGRPADDVSVLIAKRLTMRGFLILDYRKSREAIATLAGWLRDGRLKAEETVADGLTNAPDVLNRLFDGSHRGKLVLRVDPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH1</accession>
    <name>Q63JH1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190805.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111751.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1745"/>
    <dbReference type="EnsemblBacteria" id="CAH39220">
        <property type="protein sequence ID" value="CAH39220"/>
        <property type="gene ID" value="BPSS1745"/>
    </dbReference>
    <dbReference type="GeneID" id="56598099"/>
    <dbReference type="KEGG" id="bps:BPSS1745"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5172"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPYPFID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="23427" checksum="B9F87082219306C8" modified="2004-10-25" version="1">MQKAAFVAAYRLVGCGLILSATCHSIARRWNAPTFRLDNFLSYFTQLSSLYTAIVLLAGLWLATKPPSRRYESARGAVVLYMAITGIVYELLLAHLDAVHHATPYYTNWILHRVIPIAVFLDWLYVAPRVRIDWSQLARWLAFPVAYLGYTLVRGALIDWYPYPFVDPRAHGYLMVAAYSGAIAAGSIGFAALIVLLGNRTGAPAPQAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JR0</accession>
    <name>Q63JR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111662.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1656"/>
    <dbReference type="EnsemblBacteria" id="CAH39130">
        <property type="protein sequence ID" value="CAH39130"/>
        <property type="gene ID" value="BPSS1656"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1656"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5944"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TPDDMRG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="418" mass="43219" checksum="41497E32BA1DB313" modified="2004-10-25" version="1">MLTSVAPPSATSEAVSHRNTAVLVVFTALTNLADGVTKVALPLMATALTHSPARISGVSLTLTLPWLLVALHVGVLVDRFDRRTLLWLANAARMAAMALLIALLPSGRVTLPVLYASGLTLGLAEVVALTSAAALIPDAVAPSSRERANAWIAGAETVCNEFCGPLTGGMLVAAGTAIALGAVAVGYFGGGVALFFLIGRFRVAHAPHGRPPPVRLQIAEGLGCLWHQPLLRLMAVALTVLCMCWGAWLALMPLFATTVLGLDSRGYGVTVSALGVGGFVGALSVTLLNRRFGRRTVMLTDLLGTFAMMAVPVLSTNLWAVAASAFAGGLGGTLWTVNARTISQHLVPGPLLGRYNAAARLFSWGAMPIGAGLAGAIAELLGMRAAFAALAVAALLLIVPFLRVASAQALRIGPERRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JR1</accession>
    <name>Q63JR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188644.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111661.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1655"/>
    <dbReference type="EnsemblBacteria" id="CAH39129">
        <property type="protein sequence ID" value="CAH39129"/>
        <property type="gene ID" value="BPSS1655"/>
    </dbReference>
    <dbReference type="GeneID" id="56598007"/>
    <dbReference type="KEGG" id="bps:BPSS1655"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5943"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="46" mass="4564" checksum="7D04736976ED78BE" modified="2004-10-25" version="1">MQAAAPGIAVLGATGSFDASLDEDVAAALRREADATGTALGYRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K03</accession>
    <name>Q63K03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative LysE-family translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528842.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111569.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1563"/>
    <dbReference type="EnsemblBacteria" id="CAH39036">
        <property type="protein sequence ID" value="CAH39036"/>
        <property type="gene ID" value="BPSS1563"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1563"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4928"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIHFVIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="208" mass="21633" checksum="633FC703657A0E3A" modified="2004-10-25" version="1">MFSAHLLLVYVAAVVAVYAVPGPDMAFVLQTGIGRGARHGAAAAAGLGLARAVHVTLSACGVAALLKSAPWLYEAVRYGGALYLAYVAVQIFRSPAFALSAADAAAPAARLRHTFVKGLLTNLLNPKALLFCSVLLPQFVQRGGAPVIAQMAVLGAVLVLAGLCFDLACVAGATRIAEWLRAHPLAQLAQRWTFSAVLLGFALRLSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K40</accession>
    <name>Q63K40_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative invasion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bapC</name>
        <name evidence="2" type="ordered locus">BPSS1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188424.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111532.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K40"/>
    <dbReference type="STRING" id="272560.BPSS1526"/>
    <dbReference type="EnsemblBacteria" id="CAH38999">
        <property type="protein sequence ID" value="CAH38999"/>
        <property type="gene ID" value="BPSS1526"/>
    </dbReference>
    <dbReference type="GeneID" id="56597871"/>
    <dbReference type="KEGG" id="bps:BPSS1526"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4881"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQHESGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="20200" checksum="3408FC19CC54D335" modified="2004-10-25" version="1">MSARRAEAARPRGYAARIARVAAAFAIGIVSAGGVAHADCIDDAARRYGVNADLLRSIAYYESGLNPRALHRNGDGSTDIGLMQINSVHLPALRDQGIDRLRLYDASINARVGAALLRRQIDQYGDTWRAVGAYHSRTPGLSERYARAVHDVYVARPWAAKAAARRDAAHTMPARAPGLVIEEASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K76</accession>
    <name>Q63K76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004206326.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111496.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1489"/>
    <dbReference type="EnsemblBacteria" id="CAH38962">
        <property type="protein sequence ID" value="CAH38962"/>
        <property type="gene ID" value="BPSS1489"/>
    </dbReference>
    <dbReference type="GeneID" id="56597741"/>
    <dbReference type="KEGG" id="bps:BPSS1489"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4832"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPRLVAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266527" evidence="3">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="204" mass="21648" checksum="3ABB687831BBC80B" modified="2004-10-25" version="1">MKLDYFTARGALALLAAACVATAAHGADAPAAAATPPAATATDSLYQANATLTDQDGKTFRLADLRGTPTLVSMFYTSCKMVCPMLFETIGLTLDAGGEPARKRIKVVAVTVDPDRDSVAVLRKTANAHGLDARWRLVRTDRDSTRTVAALLGIQYRKLASGEFNHSSTIVLLDADGRIVAHTNTLGETDPAFVDAMRKQLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA4</accession>
    <name>Q63KA4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111468.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1462"/>
    <dbReference type="EnsemblBacteria" id="CAH38933">
        <property type="protein sequence ID" value="CAH38933"/>
        <property type="gene ID" value="BPSS1462"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1462"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5704"/>
    <dbReference type="eggNOG" id="COG5591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CYEVRGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13670">
        <property type="entry name" value="PepSY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="118" mass="12845" checksum="31C9CAD200D6D280" modified="2004-10-25" version="1">MADDGDDCRAPLADWKPRDAVRALAQQKGWRVDKLKADDGCYEIKGHDADGKRFKAKLDPVTLDVVRMKREGERKRDHDDDDDHGRAPDARAPAGGPPAGAPPGGVLKPGSKPDVQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KI9</accession>
    <name>Q63KI9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528682.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111383.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1372"/>
    <dbReference type="EnsemblBacteria" id="CAH38844">
        <property type="protein sequence ID" value="CAH38844"/>
        <property type="gene ID" value="BPSS1372"/>
    </dbReference>
    <dbReference type="GeneID" id="56530204"/>
    <dbReference type="KEGG" id="bps:BPSS1372"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4686"/>
    <dbReference type="eggNOG" id="ENOG5033C79">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EQMLPDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="9147" checksum="E8E11B5C5B1BD518" modified="2004-10-25" version="1">MKAEAVLPDHVNRVEIDGVSIRKGTVAAFLASARVWTDAQAAAHAREEAERDLLDTLPSLRVLGLFDVLEIRDARLRAFVDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KK3</accession>
    <name>Q63KK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188466.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111369.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1359"/>
    <dbReference type="EnsemblBacteria" id="CAH38830">
        <property type="protein sequence ID" value="CAH38830"/>
        <property type="gene ID" value="BPSS1359"/>
    </dbReference>
    <dbReference type="GeneID" id="56597564"/>
    <dbReference type="KEGG" id="bps:BPSS1359"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4665"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FEKFWFS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="16749" checksum="87652BD223241148" modified="2004-10-25" version="1">MIADERGNFVEILLVEDSPTDVMMTKEALEYYKVLNPLNVVEDGVAAMAYLRREGPYAGARRPGLIILDLNLPRKSGREVLQELKLDPELSTIPVVILTTSKSEEDVARSYGLHANCYITKPVDFAKFTDVVHSINEFWLSVVTLPPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM9</accession>
    <name>Q63KM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome-c methylamine utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205595.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111342.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1332"/>
    <dbReference type="EnsemblBacteria" id="CAH38803">
        <property type="protein sequence ID" value="CAH38803"/>
        <property type="gene ID" value="BPSS1332"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1332"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4630"/>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HNGVFKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="163"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="347"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="540" mass="57067" checksum="C9875A368EB55473" modified="2004-10-25" version="1">MTGGKRSGAARRAGAAFAARGPALAGAPGARNARRIVSTLAIAAVTRAAGGALAACASAIAFASGAAAPGALDAVRAAYPASSLSPARTPGAGGAAHVKPVQEALRAKAASPSPSLLPSPPSPTTSLLPGAPPQRVVATIGRGTPQVASKVDPTAAAFHPDPALAALGKRVFFDPALSEPRGTSCASCHDPGRAFAPTLSRAALAGPRVPQGSRPGHFSRRNAPSLLYVRYVPRRHFYQDDDALAPAPFGGLFSDGRADTLAEQLRGPLFDPDEMNNASPAALTRKIGGTALGAALAERFGPSVRRDPERMVRALGEAMQAYLQSDEMAPFSSRYDAYVMQRAPLTPQEKRGLALFRNPDKGNCMSCHTLSDTASRPERSLFTDFGYDAIAVPRNRALRANRDPRHFDNGLCDTAAKLRWPEPAQWCGYLRTPGLRNVAIKESFMHNGVFDTLRDAVAFYNTRSTDPKRWYHGRDTFDDVPAAYRGNINVNSTPMNRRAGTPPAMTDADVDDIVAFLRTLTDARYVGLMPAAPDGKAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KR7</accession>
    <name>Q63KR7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroG</name>
        <name evidence="8" type="ordered locus">BPSS1295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184633.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111304.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1295"/>
    <dbReference type="EnsemblBacteria" id="CAH38765">
        <property type="protein sequence ID" value="CAH38765"/>
        <property type="gene ID" value="BPSS1295"/>
    </dbReference>
    <dbReference type="GeneID" id="56597496"/>
    <dbReference type="KEGG" id="bps:BPSS1295"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4580"/>
    <dbReference type="eggNOG" id="COG0722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PCLSWED"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="7">
        <location>
            <begin position="64"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="372" mass="40360" checksum="213E09389B458F5C" modified="2004-10-25" version="1">MQNIDNPQRDRETGFADATQDTTRIDDVRIGAVRPLISPALLQDELPVPSAVQALVEASRDAIGDVLHGRDDRLLAIVGPCSIHDHDQALDYARRLKSAADALRDDLLIVMRVYFEKPRTTVGWKGYINDPRLDGSFRINEGLRAARRLLIDINALGLPAGTEFLDLLSPQYIADLIAWGAIGARTTESQSHRQLASGLSCPIGFKNGTDGGVQVAADAIVAARASHAFMGMTKMGMAAIFETRGNDAAHVILRGGKRGPNYDRASVDEACAVLRAAGQREQVMIDCSHANSNKSHLRQVDVAEDLARQLSDGERRITGVMVESNLEAGRQDLKPGVPLQYGVSITDACLSWAQTEPVLDTLAQAVRRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LI0</accession>
    <name>Q63LI0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205513.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111041.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38496">
        <property type="protein sequence ID" value="CAH38496"/>
        <property type="gene ID" value="BPSS1035"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1035"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="8886" checksum="4C575FA3D1C01A45" modified="2004-10-25" version="1">MFSTRSHVLPRVVLLGEPLANAPFVDGEITRPFRDGFWLLPYSTLCLPLAASDTVIVEPDRPGSAGALAGRQLDAGRQSPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LN7</accession>
    <name>Q63LN7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative gluconate dehydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198666.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110984.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0976"/>
    <dbReference type="EnsemblBacteria" id="CAH38438">
        <property type="protein sequence ID" value="CAH38438"/>
        <property type="gene ID" value="BPSS0976"/>
    </dbReference>
    <dbReference type="GeneID" id="56597342"/>
    <dbReference type="KEGG" id="bps:BPSS0976"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7296"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAPYPST"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="3">
        <location>
            <begin position="234"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="5">
        <location>
            <begin position="409"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="537" mass="59529" checksum="ED5E591F6C2B3C88" modified="2004-10-25" version="1">MADTQQADVVVVGSGVAGAIVAHQLAMAGKSVILLEAGPRMPRWEIVERFRNQPDKMDFMAPYPSSPWAPHPEYGPPNDYLVLKGEHKFNSQYIRAVGGTTWHWAASAWRFIPNDFKMKTVYGVGRDWPIQYDDIEHDYQRAEEELGVWGPGAEEDLLSPRKQPYPMPPLPLSYNERTIKTALNNHDPKYHVVTEPVARNSRPYDGRPTCCGNNNCMPICPIGAMYNGIVHVEKAEQAGAKLIENAVVHKLEVGPQKKIVAARYKDPKGVEHRVEGKYFVLAANGIETPKLMLMSTSHDFPNGVGNSSDMVGRNLMDHPGTGVSFYASEKLWPGRGPQEMTSLIGFRDGAFRATEAAKKIHLSNLSRVDQETQKIFKTGKLLKPAELDAQIRDRSARYVQFDCFHEILPQPENRIVPSRTATDAIGIPRPEITYAIDDYVKRGAAHTREVYATAAQVLGGTDVAFNDEFAPNNHITGSTIMGADPRDSVVDKDCRTFDHPNLFVSSSATMPTVGTVNVTLTIAALALRISDQLKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M04</accession>
    <name>Q63M04_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="6">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539063.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110867.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0855"/>
    <dbReference type="EnsemblBacteria" id="CAH38318">
        <property type="protein sequence ID" value="CAH38318"/>
        <property type="gene ID" value="BPSS0855"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0855"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7142"/>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QDNQIRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040603">
        <property type="entry name" value="FAN1_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="PTHR15749"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18081">
        <property type="entry name" value="FANC_SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="435"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="564" mass="63550" checksum="681FA2378323C4E5" modified="2004-10-25" version="1">MPPDPPSPPAFYYLSNFERALAWLVERYDDVLDAEEHAFVAAFGALPRASRALLVRMLMRKGPMFRASKLVYDEIGCPFAAAAPLVALGWIDPQPMLSLDALFALATKAELRDAFSDAPASGALRKADWLDALRARHDGERPWAQWLPSIDDRVLRVTVDALCNRLRLMFFGNLHQDWSEFVLADLGLLQYEAVAFAPSSRAFQRRGDVDAYLQLHACREQLDAWPDDAPLAPLVEAAAAVDCGNAWLAMRRAKLTYAIGRACERRADWGGALDAYASSAWPGSRQRRVRVLERCERFDAALALADEAAREPENEAQAQQIARMLPRLRRRAGLPTARAPRAQEIPRGCVELAHPGVPYPVEYVARDHLSRADAPVFYVENALVNSLFGLLCWEPVFAAVPGAFFHPFQRGPADLHAPDFRARRAAQFDACLAQLDGAQYRDTIRRHYAQKRGVQSPFVFWAALDETLLEHALACLPAEHLRLWFERLLDDVRGNRSGLPDLVRFWPAERRYELIEVKGPGDRLQDNQIRWLDYCVRHRMPVRVLDVRWTGDARASSQGEEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M58</accession>
    <name>Q63M58_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110813.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0803"/>
    <dbReference type="EnsemblBacteria" id="CAH38264">
        <property type="protein sequence ID" value="CAH38264"/>
        <property type="gene ID" value="BPSS0803"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0803"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4879"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEVFHSL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="22741" checksum="FEAD7DFCE063AD5E" modified="2004-10-25" version="1">MESRVVHVGERFNSISHLVGAVLSVAGLATLVTMGALDGDAYKVVSFSVYGAMLCVLYAISTLYHSVRGPRLKAILQKCDHAAIYLLIAGSYTPFTLVTLRGPWGWSLFGVSWGLAAFGIVQELTLGRRTRIVSMALYVLMGWLALVAIRPLVHALPAAGTAWLVAGGVIYSAGIYFFVNDERIRHGHGIWHLFVLAGSLCQFVSVAGYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M71</accession>
    <name>Q63M71_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201854.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110800.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0791"/>
    <dbReference type="EnsemblBacteria" id="CAH38251">
        <property type="protein sequence ID" value="CAH38251"/>
        <property type="gene ID" value="BPSS0791"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0791"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7043"/>
    <dbReference type="eggNOG" id="COG3618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWPVCLV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="29892" checksum="313C595EED73BE11" modified="2004-10-25" version="1">MTRTVDAHQHYWDPSRGDYGWLTPALAPLHRVFGPADLAPLRAAAGVARTIVVQAAPSVDETRYLLDLARCEPSIAGVVGWAPLDAPDARDTLAALARDPAFKGVRPMLQDLPDAAWIANPALAGAIDALVELDLAFDALVTPSHLAPLATFARRFPRLRIVVDHGAKPPIRAGRAAWQPWADGIAALGALPNVHCKLSGLATEAAHGWRRESLAPYVDHLFDAFGAARMIWGSDWPVLNLNGDYAGWHASARALAAARVGERACDAVFGENAAAFYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M96</accession>
    <name>Q63M96_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551516.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110775.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0764"/>
    <dbReference type="EnsemblBacteria" id="CAH38224">
        <property type="protein sequence ID" value="CAH38224"/>
        <property type="gene ID" value="BPSS0764"/>
    </dbReference>
    <dbReference type="GeneID" id="56530785"/>
    <dbReference type="KEGG" id="bps:BPSS0764"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7006"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGPLDHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="27357" checksum="1D20D199A37E2FA9" modified="2004-10-25" version="1">MAAIDLLKPYAGLRVLVTGGASGIGLAIADAFAECGGQVHVCDASGKALAALAQRPSRAALGTTLADVADAAAVERVFDDVTRTLGGLDVLVNNAGIAGPTGGIDEIDPAQWEQTVAVNLNAQFQFARRAVPMLRDAPHGGAIIALSSVAGRLGYALRTPYSATKWAVVGLVKSLAIELGPLGIRVNAIQPGIVRGPRIRRVIEARAAQLGIGYDEMQARYLEKISLRRMTDPDEIAATALFLCSPGGHGISGQAISVCGNVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MB3</accession>
    <name>Q63MB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200849.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110758.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0747"/>
    <dbReference type="EnsemblBacteria" id="CAH38207">
        <property type="protein sequence ID" value="CAH38207"/>
        <property type="gene ID" value="BPSS0747"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0747"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6983"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGRIEYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0626">Porin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266587" evidence="5">
        <location>
            <begin position="25"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="6">
        <location>
            <begin position="17"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="39149" checksum="2B56D6B7365F0A32" modified="2004-10-25" version="1">MKRKSLAMAVAGIGIGAAVPPALAQSSVTLYGIVDSGITYTNNQKGHSAWKATSGNEQAARWGLVGREDLGGGTSAIFRLENGFDIENGTASQGGRLFGRRTYIGLANDRWGAFTMGRQYNAVQETLAPLHIATVLGRYAHHPFDADDLDSTFRTNNSVQYQTPDWGGVRAIATYGFSNSTSFARNRTWSVGASYARGPLQLAAAYVRVDYPAIDATGAIASDNYYGFVKGVARQQIWGAGGAYAWGGATFGLLYTSALFSLQTGGAERFNNFEGSVRYRVTPAVQVALGETYTQVLASHAAAHDAHYLQTSAGIQYFLSKRTDVYLNVSYQRASSNAVAWIKGLDGASSTRTQIVAVTGIRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MH1</accession>
    <name>Q63MH1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS0686a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549591.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110700.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0686a"/>
    <dbReference type="EnsemblBacteria" id="CAH38146">
        <property type="protein sequence ID" value="CAH38146"/>
        <property type="gene ID" value="BPSS0686a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0686a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6900"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="6524" checksum="1BA4DD459C759279" modified="2004-10-25" version="1">MTAARGARPVGGVPPPTHVRARAGVASGVMAAGARSGACAPIVETAESGDSTDFTESAESTRAADIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR7</accession>
    <name>Q63MR7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pchA</name>
        <name evidence="6" type="ordered locus">BPSS0581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554846.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110602.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0581"/>
    <dbReference type="EnsemblBacteria" id="CAH38038">
        <property type="protein sequence ID" value="CAH38038"/>
        <property type="gene ID" value="BPSS0581"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0581"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6756"/>
    <dbReference type="eggNOG" id="COG1169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGHGQSI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="204"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="484" mass="51820" checksum="B515218673D1E41D" modified="2004-10-25" version="1">MSARLSALLDTFARAARRAADTGEPVLAAASFPLRPLNLFDLIASWDDGATPWCFVEAGDEPGAMRAPGKPPALFGWDCALDLNEAGDARFARLDARWRALVRAAVVTGAQPPRIVGGFRFDPLGPRYAHWHAFADASMTLAKLLVVREGEAYWAVCQRVVAAHDDPAALARECDARIGMLASLAPAADDEAPRLLRVQALQAAAWQHEVRRAVDAIRGEAFSKVVLARDVLQQYARPVAIGPLLRRLRRRDPRAHLFAIRRRDGCFVGATPERLARVAHGRAHTHALAGTIARGNDPAHDRALGAQLMASAKERLEHALVVDAIRDALAPLSRAIDVPAQPSLLRLPRLQHLSTPIAAALNERATLLQVVAALHPTPAVAGHPRAAALEHIRAHEGFDRGWYAGPIGWIDAHGNGDFVVALRSALISAGACRLFAGCGIVAASEPAREYRETSLKLSGMQAAIEARDAAAAARTVAPIPSAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MV9</accession>
    <name>Q63MV9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205425.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110560.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0539"/>
    <dbReference type="EnsemblBacteria" id="CAH37996">
        <property type="protein sequence ID" value="CAH37996"/>
        <property type="gene ID" value="BPSS0539"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0539"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6704"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVCAIPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="331" mass="36328" checksum="D6321E448F3E937A" modified="2004-10-25" version="1">MTTLGALVILYYPTDEQLSGLEALARDSDALAVIDNTPHEHAAARERVRALAARAHGEARVVWRHHGNRGGVAGAYNAGLSALFAQGMEAVALFDQDSTVPAAYFARMRDACAQLGTQPGVHAGAFIAGPRIYDANEQRFLPELMTSGVAVRRVRVEGERAPQRCAFLISSGSVISRGAYARLGRFDEALFIDHVDTEYCLRALAHNVPLYVVPSLVLTHRIGARRRHKVGPFELTAMHHGWLRRYYGARNAMQLGLQYGLRFPVALVPNLLTIWQVVQVVLCEREKGAKLRGIALGVLDGVFGRLGSFEAARAGHRTAREEAMREARQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MX4</accession>
    <name>Q63MX4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190563.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110545.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0524"/>
    <dbReference type="EnsemblBacteria" id="CAH37981">
        <property type="protein sequence ID" value="CAH37981"/>
        <property type="gene ID" value="BPSS0524"/>
    </dbReference>
    <dbReference type="GeneID" id="56531027"/>
    <dbReference type="KEGG" id="bps:BPSS0524"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6685"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YNGINRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="3">
        <location>
            <begin position="380"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="762" mass="82467" checksum="92874AA0B0AF6BA4" modified="2004-10-25" version="1">MRLIELRSPLLDPDAVALSFVVHENLSQEPSYQLDLLSHDSNLDFDALLGSTLSADIDLGEGDIRTFNTHVFGGYDTGQMSGQYTYTLELRSWLSFLAENRNSRIFQDLSVPQIVEQVFQGHQRNGYRFELEGTYEPREYCVQFQETDLNFVKRLLEDEGIYFWVEHEPDRHVVVISDTQRFEDLPLPNDTLEYLPDGEESRAIQGREGVQRLQRTRRIKSNNVALRDFDYHAPSKQLDSDAQVEQQSLGGIPLEYYDYAAGYRDPEQGERLARLRLEAIQADAHALGGEANARALAVGRAFTLVGHPALSRNRRYYVTNSELTFIQDGPDSTSQGRNVAVKFRALADDQPFRPLLVTKRPRVPGIQSATVVGPEMSEVHTDKLGRIRVHFHWDRYKTTEADASCWIRVTQAWAGKGWGVLAMPRVGQEVIVVYVDGDLDRPLATGIVYNGENPTPYDLPKDIRYTGLVTRSIKRAGGIPNASQLTFDDQHGAERVMIHAERDLQQTVERNSSTSIAQDLNLSVKGTSTSVVGISVSFTGISVSYTGLSVSFTGVSARFTGVSTSFTGVSTSFTGVSTSFTGVDTSFTGVSTGFKGVDTSFTGVATSMVGVSTSITGSSNSVTGVSNSMTGISSSWKDVSMSTTGQSESITGVSLSYTGTSNSMTGTSTSVTGTSTSITGTSMSNTGSSTSITGTSMSTTGSSVSTTGSSMSATGSSVGTTGSSVSTTGSKMSVTGFSFSYTGASYEDVGVDLKKLGMQTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY4</accession>
    <name>Q63MY4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA hydrolase/transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110535.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0514"/>
    <dbReference type="EnsemblBacteria" id="CAH37971">
        <property type="protein sequence ID" value="CAH37971"/>
        <property type="gene ID" value="BPSS0514"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0514"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4526"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEALSWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017821">
        <property type="entry name" value="Succinate_CoA_transferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03458">
        <property type="entry name" value="YgfH_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="5">
        <location>
            <begin position="355"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="2">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617821-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617821-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="534" mass="57562" checksum="2D4E795AD9790D53" modified="2004-10-25" version="1">MPQAPGARATPETPLRRSVARSTTTVRHSAMPTSRILAPSLRSLVRTADEAAALIGPNMTVAMSGFTGSGYPKAVPAALAARIAASHARGEDFRINVLTGASTAPELDGALAKADGISMRLPYQSDPTLREKINAGELDYQDIHLSHVAQYAWFGLFGELDVAIVEVAGIREDGRLIPSASVGNNKTWLDQAKRVILEVNARQPLGLDGMHDIYYGTALPPNRKPIPLVKSDDRIGEPYLRCPAEKIVAIVETDAPDRSNAFAAPDETSKQIAGLLIDFLRHEIKRGRLPEHLLPLQSGVGNITNAVLAGLGEGGFSNLSAYTEVIQDGMLDLLANGTLSFASATALSLSPDAVKRFADEIDTFRSKIVLRPQEISNHPELVRRLGIIAMNGMIEADIYGNVNSTHVMGTRIQNGIGGSGDFARNGYLSCFMSASTAKGGAISRIVPMASHVDHTEHDVAVVVTEQGLADLRGLSPKQRARKVIANCAHPDYRPMLEDYFERASRESFGKQTPHLLGEALSWHERYVRTGSMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N15</accession>
    <name>Q63N15_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004548628.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110504.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0482"/>
    <dbReference type="EnsemblBacteria" id="CAH37938">
        <property type="protein sequence ID" value="CAH37938"/>
        <property type="gene ID" value="BPSS0482"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0482"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6634"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRIACST"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="30558" checksum="CB4FFB4855E185F4" modified="2004-10-25" version="1">MKILGAGIAVPGGAAHALEFANDYALKAARQALAKARCLPSELDLIVSLSVSPNRMADAAPIAGPRLAHPVQRDLRASNAAVFDLLDADWTLALDLVQSHCRQLGYRRALVVKAEALADVEGAQAGGYADGAGAIVLAPGRGDRYHASYADLDAPSLATLAGVGARHAHETGAVARFEGGFDPAAGSFRRVPRNAGAAMREVVGDVRSKVDAPISELFRESWLRGWLEDEAGFAGEPRVDVIDGDAGVPAAFQLPAWLAARAGGGAAAGVRGGAQVVAALTLDAFKPRIACIAMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N28</accession>
    <name>Q63N28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529984.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110491.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0469"/>
    <dbReference type="EnsemblBacteria" id="CAH37925">
        <property type="protein sequence ID" value="CAH37925"/>
        <property type="gene ID" value="BPSS0469"/>
    </dbReference>
    <dbReference type="GeneID" id="56531080"/>
    <dbReference type="KEGG" id="bps:BPSS0469"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6616"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTLQVIH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="107"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="444" mass="50194" checksum="149CE320ECAD7E08" modified="2004-10-25" version="1">MQDIDEFLKKHRITEIEAIIPDMAGIARGKIIPRSKFETGESMRLPQAVMIQTVTGDYPEDGSLTGVTDPDMVCLPDASTIRLIPWAIDPTAQVIHDCVHFDGTPVEISPRRVLRRVLELYKAKGWKPVIAPELEFYLVDMNKDPDLPLAPPIGRTGRPETGRQSYSIEAVNEFDPLFEDIYEYCEVQDLEVDTLIHEVGAAQMEINFLHGDPLNLADRVFLFKRTVREAALRHHMYATFMSKPMENEPGSAMHVHQSIVDEETGRNLFTGDDGGPTDMFYAYIAGLQKYTPALMPIFAPYINSYRRLSRFMAAPINVQWGYDNRTVGFRVPHSSPVSRRVENRIPGVDCNPYLAIAGTLAAGYLGMTRRLEPTEPLASDGYSLPYQLPRNLEEGLTLMSACEPLAEILGEKFVKAYLALKETEYEAFFRVISSWERKHLLLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NR4</accession>
    <name>Q63NR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-allo-threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ltaE</name>
        <name evidence="6" type="ordered locus">BPSS0236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529784.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110255.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0236"/>
    <dbReference type="EnsemblBacteria" id="CAH37682">
        <property type="protein sequence ID" value="CAH37682"/>
        <property type="gene ID" value="BPSS0236"/>
    </dbReference>
    <dbReference type="GeneID" id="56531309"/>
    <dbReference type="KEGG" id="bps:BPSS0236"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6319"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="35554" checksum="86698F7416565038" modified="2004-10-25" version="1">MIDLRSDTVTRPSAPMLAAMTAAEVGDDVWGDDPTVARLQAVVAERAGKEAALFFPSGTQSNLAALMSHCERGDEYIVGQAAHTYKYEGGGAAVLGSIQPQPIENAADGTLPLEKIAAAIKPIDDHFARSRLFTLENTIGGKVLPAGYVDEAVALARSRGLAAHLDGARVCNAAVASGRAIAELCAPFDSVSICFSKGLGAPVGSVLVGSGALIERAHRWRKVLGGGMRQAGVLAAACLYALEHNVERLADDHANAERLAQGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKERGILTQMLYASRFVTHCDVSRDDIDTAVAAISAYFARSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P72</accession>
    <name>Q63P72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110097.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0075"/>
    <dbReference type="EnsemblBacteria" id="CAH37519">
        <property type="protein sequence ID" value="CAH37519"/>
        <property type="gene ID" value="BPSS0075"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0075"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3991"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMIIPVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="306" mass="33308" checksum="947101FD78272CAE" modified="2004-10-25" version="1">MAVFRVTALNLRGSWRVIFDPLLLAMTLGVVLPLAVLAVASINAPLEFGGVAWGEFTLRAYQRVIFDRDWDGSLVLQQGYISIFIRSMMMAISATILCLLLGFPTALFISTRTSKWKAALLVLVTIPFWTCVVVQMTGWIIALADNGLVAQTLGFLGLLHGPLSLLYTDIATLIGLVYAFTPFMILPIFAALDDFDWQLVEAAYDLGAHQMAVLWHVIVPVCWPGVMAGVGLVFVPALGAYAIPGLLGGNHAFMVGNLIDFQFAGGRDWPLGAAMSFVLLAFVLLAMLALRLKSIFLHPESDDEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P88</accession>
    <name>Q63P88_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110081.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0057"/>
    <dbReference type="EnsemblBacteria" id="CAH37500">
        <property type="protein sequence ID" value="CAH37500"/>
        <property type="gene ID" value="BPSS0057"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0057"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3969"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWMYRIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="222" mass="25166" checksum="4DADAE5135214702" modified="2004-10-25" version="1">MQPSRVDDRALAARVAGGDHAAFEQLMRRYNRRLYRLARATLRDDAQAEDVLQEAYLAAFRTIGRFRGDASLSTWLSRLVLNACFTRQRRGARRDNIAPMVNTSSIAGFERTTMDADLTSSPDHALMRTELRALLERKLDALPEAFRLVFVLRCVEELSVEETAQCLGIPEATVRSRHFRAKRLLRESLAREIDSAGRDVFSFAGERCDRIVRGVLARLISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PJ2</accession>
    <name>Q63PJ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109977.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3385"/>
    <dbReference type="EnsemblBacteria" id="CAH37396">
        <property type="protein sequence ID" value="CAH37396"/>
        <property type="gene ID" value="BPSL3385"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3385"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3850"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APREWMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="249" mass="26752" checksum="110DB350EC69FC7E" modified="2004-10-25" version="1">MMGVSFLSLFGSIRLAKMTSRHVQVSAPPDKSIAQPQPALRRRPRQRRAQASSAALQQAFVRVLLERGYAKATIREIAAVAGVSVGTFYEYFGDKESLAALTIHHYVKTLATRMRAVVDARRGELGRAVAAALIDTQVDAIEQDPCVWAAMFAIERKVSPIDAYRRHYDDYVALWRDALAGASDAPADARLDVTARVAHALCYGWVSQSLLTQGAKVDVAQLRDELHRAAGAYLAAAMDGGAGGGAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PQ8</accession>
    <name>Q63PQ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Cof-family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109911.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3315"/>
    <dbReference type="EnsemblBacteria" id="CAH37328">
        <property type="protein sequence ID" value="CAH37328"/>
        <property type="gene ID" value="BPSL3315"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3315"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3769"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CCAERGI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="30641" checksum="5ED02F29DFC162F0" modified="2004-10-25" version="1">MHPPMSAMYKAIATDLDGTLLNSDHQLDPYTIDTVRRLAGSGVPFVIATGRHYADVAGIRDVLGIRPYLITSNGARVHGPDDTRIHAQDVPADAVRQLVRPELVGTHGRVIVNLFTNDGWLIDRDAPQLLAFHQDSGFRYEIVDMLAHDGADIAKVLYIGEPEDLAVVSGNLARRFGDALYVTYSLPDCLEVMTANVSKGRALRVVLERLGVDPAHCVAFGDNMNDIDLLETAGYPFMMNNANPDLALRLPKVPRIGNNFEAGVARHLRALFALEDSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PU3</accession>
    <name>Q63PU3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109875.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3279"/>
    <dbReference type="EnsemblBacteria" id="CAH37292">
        <property type="protein sequence ID" value="CAH37292"/>
        <property type="gene ID" value="BPSL3279"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3279"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3730"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EAIRGFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="18518" checksum="D25AECBA6D44DD67" modified="2004-10-25" version="1">MPNVVAALEAQVTLDTFSQKILRLLQLDARRSVQEISDQVGLSSTPCWRRIKDMEQSGVIQRYTALLDREKLGLHICALAHVHLTRHNEGGVEQFEREIATCPEVTECYSTTGEADYILKIVAPDIKAYDIFLHERIFKIPAVSQVRTSVVLREIKFDTQLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PW3</accession>
    <name>Q63PW3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative plasmid conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109855.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3259"/>
    <dbReference type="EnsemblBacteria" id="CAH37272">
        <property type="protein sequence ID" value="CAH37272"/>
        <property type="gene ID" value="BPSL3259"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3259"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1965"/>
    <dbReference type="eggNOG" id="ENOG5032PRC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DALGPTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016703">
        <property type="entry name" value="Conjugal_tfr_TraD_b/g-type"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017849">
        <property type="entry name" value="Conjugal_transfer_TraD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="68" mass="7287" checksum="71FB2B23E844F189" modified="2004-10-25" version="1">MSADSNEKESNVNLGGKRSDAPEPTFIDEIGPLDVVPLIITRGNARELLGRRPGETVAQALVRMAKQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q12</accession>
    <name>RL4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">BPSL3212</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199276.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109806.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q12"/>
    <dbReference type="SMR" id="Q63Q12"/>
    <dbReference type="STRING" id="272560.BPSL3212"/>
    <dbReference type="EnsemblBacteria" id="CAH37223">
        <property type="protein sequence ID" value="CAH37223"/>
        <property type="gene ID" value="BPSL3212"/>
    </dbReference>
    <dbReference type="GeneID" id="56594544"/>
    <dbReference type="GeneID" id="66545621"/>
    <dbReference type="KEGG" id="bps:BPSL3212"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2026"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000242352" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="206" mass="22866" checksum="B74972733F8016E1" modified="2004-10-25" version="1">MELKLLNSNGQEGAVVNASDVVFGRDYNEALIHQVVVAYQANARQGNRAQKDREQVKHTTKKPWRQKGTGRARAGMSSSPLWRGGGRIFPNSPDENFSHKVNKKMHRAGLCSIFSQLAREGRLSVVEDIVLEAPKTKLLADKFKAMGLDSVLVITDTVDENLYLASRNLPHVAVVEPRYADPLSLIYFKKVLVTKAAVAQIEELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q99</accession>
    <name>Q63Q99_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">BPSL3126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199900.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109719.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3126"/>
    <dbReference type="EnsemblBacteria" id="CAH37136">
        <property type="protein sequence ID" value="CAH37136"/>
        <property type="gene ID" value="BPSL3126"/>
    </dbReference>
    <dbReference type="GeneID" id="56594102"/>
    <dbReference type="KEGG" id="bps:BPSL3126"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2117"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="28629" checksum="894518015EB9F537" modified="2004-10-25" version="1">MSDPQHNPDDGPEETFISHLVELRDRIIRAGAAVIVVFLGLVYWAPDIFRLLARPLMENLPKGGRMIVTDVTGSFFVPMKVTMLVALVIALPVVLYQIWAFVAPGLYQHEKKLVAPLVGSSYVLFLCGMAFAYFLVFPTIFRVMAHYNAPLGAEMSTDIDNYLSFVLGMFVAFGVTFEVPIVVVLLVRMGVLTVQKLKEIRPYVIVGAFVVAAVVTPPDVFSQLMLALPLVLLYEAGIIAARLFVKPPAKEEDESKAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QL4</accession>
    <name>Q63QL4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type IV pilus assembly protein PilC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pilC</name>
        <name evidence="11" type="ordered locus">BPSL3009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549962.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109604.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3009"/>
    <dbReference type="EnsemblBacteria" id="CAH37020">
        <property type="protein sequence ID" value="CAH37020"/>
        <property type="gene ID" value="BPSL3009"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3009"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2260"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRQMATM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="71"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="405" mass="42528" checksum="9D88DA98360729C1" modified="2004-10-25" version="1">MSTRGPASPIESRYRWAGVTIDGARRRGMLIAVDPSAARAALKRTGVTVLRLEARGRAPQPAARASEVTRFARQLAGLLHAGLALAPSLELLAQATQRSEMPRVAAGLAREIVAGRQFSAALRRYPRQFDPFFCQLVAVGETAGALAAVLTRLADDRERAAAQYARVKGALAYPAAVLLFALAITAALLVWVVPTFEQIFAGFGAPLPAPTRFVLALSAGVTRWSAPAAAAALFACVAVRHTARRSAAARVALARTLLRAPFVGPLVQTLAAARWSRALGTLLAAGTPLTDAFAALSNATGNPRFDLATAGIAARVLHGERLARAMRAEGCFPDDLVQPIAVAEESGTLDTMLIDAATLCDRRVDERISALANLCEPVVIVVLGALIGALVVAMYLPIVQLGNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QQ3</accession>
    <name>Q63QQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative galactonokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194214.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109565.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2971"/>
    <dbReference type="EnsemblBacteria" id="CAH36981">
        <property type="protein sequence ID" value="CAH36981"/>
        <property type="gene ID" value="BPSL2971"/>
    </dbReference>
    <dbReference type="GeneID" id="56594220"/>
    <dbReference type="KEGG" id="bps:BPSL2971"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2304"/>
    <dbReference type="eggNOG" id="COG3734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HFDTFMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008671">
        <property type="term" value="F:2-dehydro-3-deoxygalactonokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007729">
        <property type="entry name" value="DGOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042257">
        <property type="entry name" value="DGOK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042258">
        <property type="entry name" value="DGOK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05035">
        <property type="entry name" value="DGOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="35290" checksum="FDEC589DF5CE0E4D" modified="2004-10-25" version="1">MTAQASTPALIGLDWGTTSLRAYLFAADGSVLDTRALAAGVMSLPDAPGASPQQTFDAAFERACGAWLDRAPHVPALAAGMVGSAQGWREAPYVTMPAAADTFASSLVRFRTARGSALAIVPGALEPGELPDVMRGEETQIVGALAAEPALAAERAGALIGLPGTHAKWAWVRGGRIEWFRTYMTGELFATLRGHTILGRTMQASDAPDWSAFARGVRTARRKRDEGLLATLFSTRTLGLTGQLAPHAQGDYLSGLLIGHELNALEALLGGQHASLAALAPRLVGEGALCDRYRRALAEFGCGDARIVERASERGLWRIAVQAGLVGAACDAPLAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU8</accession>
    <name>Q63QU8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194310.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109520.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2926"/>
    <dbReference type="EnsemblBacteria" id="CAH36936">
        <property type="protein sequence ID" value="CAH36936"/>
        <property type="gene ID" value="BPSL2926"/>
    </dbReference>
    <dbReference type="GeneID" id="56593763"/>
    <dbReference type="KEGG" id="bps:BPSL2926"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2356"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHVPLEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="316" mass="34904" checksum="3A6C89BBEBB5C52D" modified="2004-10-25" version="1">MELKWLEDFVSLAETRSFSRSAELRHVSQPAFSRRIQALEAWLATELIDRSVYPTRLTQAGQVFYEQALAMLSQAHEARTLLRGHVGAPVPTIEFAVPHTLSLTYFPRWLQRIEAKMGPVHTRLRALNVHDAVLSLVEGGCDLVMGYHHPSHPVALDPARYDMLTLGTEPISPFSAPGRGGRARYALPGTADAPVPYLSYTPNAYLGRMTEVIIANARAPLFLDKVYETDMAEALKAMALAGHGVAFLPHSAVEDALASGRLVRLGRAAKGAAEPFMLTMEIRLYRDKLAAQGDEPRQKLVRTLWDVVREELGATA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QW3</accession>
    <name>RL13_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">BPSL2911</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522094.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109505.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QW3"/>
    <dbReference type="SMR" id="Q63QW3"/>
    <dbReference type="STRING" id="272560.BPSL2911"/>
    <dbReference type="EnsemblBacteria" id="CAH36921">
        <property type="protein sequence ID" value="CAH36921"/>
        <property type="gene ID" value="BPSL2911"/>
    </dbReference>
    <dbReference type="GeneID" id="60548380"/>
    <dbReference type="GeneID" id="61020623"/>
    <dbReference type="GeneID" id="64462181"/>
    <dbReference type="GeneID" id="66548313"/>
    <dbReference type="KEGG" id="bps:BPSL2911"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2378"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="PRO" id="PR:Q63QW3"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000261701" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="142" mass="15971" checksum="8D5D87446836803A" modified="2004-10-25" version="1">MKTFSAKAHEVTREWYVIDATDKVLGRVASEVARRLRGKHKPEFTPHVDTGDFIIVINASKLKVTGNKTLDKKYYRHSGYPGGIYETTFGKMQERFPGRALEKAVKGMLPKGPLGYAMIKKLKVYAEATHPHSAQQPKALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ2</accession>
    <name>Q63QZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RNA-methylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194083.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109476.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2882"/>
    <dbReference type="EnsemblBacteria" id="CAH36892">
        <property type="protein sequence ID" value="CAH36892"/>
        <property type="gene ID" value="BPSL2882"/>
    </dbReference>
    <dbReference type="GeneID" id="56593702"/>
    <dbReference type="KEGG" id="bps:BPSL2882"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2412"/>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFMYKAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="4">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="47058" checksum="E2B9A13FF9AE1FA4" modified="2004-10-25" version="1">MSSPTLFDFFAPCPRGLEAALAAELAQIAARHAIAPYDAGAQVPGGVHFRGAWAAGMAANLHSRIASRVLLKIAHRPYRNEQDVYALALEQPWERWFASTQTLRVDITAIKSPLKSLEFATLRVKDAICDRLREKTGARPSIDTAQPDVRVFAFLTAGDCTLYLDTSGEPLFKRGWRLDKGAAPLRENLAAGILRLAGWTPGTPLYDPMCGSGTFVAEAAQIALGVAPGVERRFGFEKLKQYDITAWQTLKVAAMDAKRAARGKRDDLLIFGSDISGDMLEKARANLERAGVPSLWLKQIDARNMTPPAAAPGVIVTNPPYGERIEVRGRGPRGDVRETGKNRGGDEAFRRTHADSPDSEFFRALGDALKQRFAGWQAFMLSSDRTLPGQLRLRESAKTPLFNGALECRLFRFDLIAGSIRQRPAAADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R59</accession>
    <name>Q63R59_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">mutL</name>
        <name evidence="9" type="ordered locus">BPSL2814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194266.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109409.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2814"/>
    <dbReference type="EnsemblBacteria" id="CAH36824">
        <property type="protein sequence ID" value="CAH36824"/>
        <property type="gene ID" value="BPSL2814"/>
    </dbReference>
    <dbReference type="GeneID" id="56594696"/>
    <dbReference type="KEGG" id="bps:BPSL2814"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2491"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="8">
        <location>
            <begin position="231"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="7">
        <location>
            <begin position="497"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="684" mass="72686" checksum="5573948A966E5E95" modified="2004-10-25" version="1">MSEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKRISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPAAGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFATAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPASGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDTGAGTPHGATLALEAHDAHDAPDGANAPGAPLYATMPGDDATPAFSPAGAAGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RB8</accession>
    <name>Q63RB8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186509.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109350.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2754"/>
    <dbReference type="EnsemblBacteria" id="CAH36762">
        <property type="protein sequence ID" value="CAH36762"/>
        <property type="gene ID" value="BPSL2754"/>
    </dbReference>
    <dbReference type="GeneID" id="56594920"/>
    <dbReference type="KEGG" id="bps:BPSL2754"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2562"/>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYCEGNG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032092">
        <property type="entry name" value="PilW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16074">
        <property type="entry name" value="PilW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="27816" checksum="0BA4CFF5F9D23139" modified="2004-10-25" version="1">MMRTTRWRAHTLVEVMIAMALGLLILLAAMSLYRVQRAAYSAAVDAARLRDAAQAALALISQQIQMAGFVPLDAYDARAVPGLFGCAAGRPVGADGQTACDPLASRSDGLVVRYVGDGVSTWPTASGQPTDCLGQGVGAADTQPLIVNRFYARVSASTGEPELYCEGSGRPGIAQPLVEGVERLSLRYRLYGAARWADASALSVDDWANVAAVSVCVQVRGRRTGRPARYVDCEGRVASAPDTRARLAWRRYVAVRNRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF3</accession>
    <name>Q63RF3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-hydroxychromene-2-carboxylate isomerase</fullName>
            <ecNumber evidence="1">5.99.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate</text>
            <dbReference type="Rhea" id="RHEA:27401"/>
            <dbReference type="ChEBI" id="CHEBI:59350"/>
            <dbReference type="ChEBI" id="CHEBI:59353"/>
            <dbReference type="EC" id="5.99.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. NadH family.</text>
    </comment>
    <dbReference type="EC" id="5.99.1.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186002.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109315.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63RF3"/>
    <dbReference type="STRING" id="272560.BPSL2719"/>
    <dbReference type="EnsemblBacteria" id="CAH36727">
        <property type="protein sequence ID" value="CAH36727"/>
        <property type="gene ID" value="BPSL2719"/>
    </dbReference>
    <dbReference type="GeneID" id="56594960"/>
    <dbReference type="KEGG" id="bps:BPSL2719"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2608"/>
    <dbReference type="eggNOG" id="COG3917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDLYRHW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018845">
        <property type="term" value="F:2-hydroxychromene-2-carboxylate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901170">
        <property type="term" value="P:naphthalene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03022">
        <property type="entry name" value="DsbA_HCCA_Iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044087">
        <property type="entry name" value="NahD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="3">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="212" mass="24134" checksum="54592B1BEC27CAC6" modified="2004-10-25" version="1">MTVGLDASQPIWFYDFLSPFSYLLLEQHDKWPGIAFALAPVALADLHRHWGQRYAYGVPAKRVFTYRHALFRAEQLGIPFRMPPAHPFDSTRALLLAIALDSDVQAIREIFRFIWREGRDPSAPDNFAELCGRVGIAHDDDRLTSDETLAQLRRNTDDAISLGVFGVPTFWLNRQLFWGEDALPMVLYCARTPSWLESSEVRRISTLPSGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX3</accession>
    <name>Q63RX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL2547A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109144.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2547A"/>
    <dbReference type="EnsemblBacteria" id="CAH36555">
        <property type="protein sequence ID" value="CAH36555"/>
        <property type="gene ID" value="BPSL2547A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2547A"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2907"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9278" checksum="0304DF9B7971510C" modified="2004-10-25" version="1">MRFSHRDGAAECDRRTNRPPPSAQTTRHQYKTENRLTCPPSIARYRLGKRVATLTADAGAGSALPADPSAEVCSPEAAKAELAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S46</accession>
    <name>Q63S46_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 7">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL2476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189313.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109071.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63S46"/>
    <dbReference type="STRING" id="272560.BPSL2476"/>
    <dbReference type="EnsemblBacteria" id="CAH36482">
        <property type="protein sequence ID" value="CAH36482"/>
        <property type="gene ID" value="BPSL2476"/>
    </dbReference>
    <dbReference type="GeneID" id="56596482"/>
    <dbReference type="KEGG" id="bps:BPSL2476"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2908"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="18480" checksum="E4FC0514BE8E80B3" modified="2004-10-25" version="1">MTTLTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIVVTRDAARRFDGCDTVTSLDDALALAARDGAAEAFLIGGAQLYEEGLRHADKLIVTEIDQDFEGDASFPAPDPAQWEAVSRDAHRAAQPNDFTYAFVVYRRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SA1</accession>
    <name>Q63SA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 interacting response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192300.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109015.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2423"/>
    <dbReference type="EnsemblBacteria" id="CAH36426">
        <property type="protein sequence ID" value="CAH36426"/>
        <property type="gene ID" value="BPSL2423"/>
    </dbReference>
    <dbReference type="GeneID" id="56596338"/>
    <dbReference type="KEGG" id="bps:BPSL2423"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2967"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECLSYEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="144"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="465" mass="50616" checksum="C4A2D2854AEA3D9D" modified="2004-10-25" version="1">MPHALIVEDDPNSLSGLTALLGADGFSVDTATSLAEARGALARSIPDVVLVDLNLPDGSGFDLLQNLPQQQPNGSLPVIVLTGNATVESAIEGLRHGVWDYLLKPVNIPRLRSLLARIPRPYELIEEVQALRATLRRLGRFGSLVGRSDAIQHVYDMIEHNARTETAVLLWGEPGTGKEAAARTLHELSRRRKGPFIAFDCRAAVQSPRNIETNGRAIESMLLGRERGAYTGVERRDPGLFEQASGGTLLLGEITALPLSLQEALLRALDSQNFMRVGGTTEIASDFRLIATTRRPAREAVANGTLREDLWLRLDAASIGLPPLRERDDDVVVMAEAFVDDLNRDARAAGLNITDKRLAPGFIRECLAYDWPGNVRELQERVRIAYDQSGDFIETLRAGDAYPQPGAALNGSSVQVRVGTPLADVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SB1</accession>
    <name>Q63SB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192175.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109005.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2413"/>
    <dbReference type="EnsemblBacteria" id="CAH36416">
        <property type="protein sequence ID" value="CAH36416"/>
        <property type="gene ID" value="BPSL2413"/>
    </dbReference>
    <dbReference type="GeneID" id="56596325"/>
    <dbReference type="KEGG" id="bps:BPSL2413"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2980"/>
    <dbReference type="eggNOG" id="COG2847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MKMQQVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266550" evidence="1">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="15794" checksum="307890A914A4622F" modified="2004-10-25" version="1">MTLKPTLLAALAALSLSLNAHAAGAASISAQNAWVRWLPNKLPAAGYVTLVNASDKPIDLVEVDSPEYGMTMLHQTVSNGSTQKMEMVDKLTIPARGKVDIAPGGYHFMLEEPKRAIKPGDTVHLRMQFSDGEKLDAPFAVKSPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SC5</accession>
    <name>Q63SC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527445.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108991.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2399"/>
    <dbReference type="EnsemblBacteria" id="CAH36401">
        <property type="protein sequence ID" value="CAH36401"/>
        <property type="gene ID" value="BPSL2399"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2399"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3001"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPKLNNC"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017835">
        <property type="entry name" value="Hopen-assoc_HpnI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="PTHR12726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03472">
        <property type="entry name" value="HpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="393" mass="42168" checksum="A45D08727BB2E2D6" modified="2004-10-25" version="1">MTESLSIVGWVLLALVCASCGYAVLAACAPAPRVPRAARARDGFEPVSVLKPLCGSEPHLYENLATFCEQRHPRYQLLFGVASAADPAIAVVRRLQADYPDCDIELVIDARVYGSNLKVSNLVNLAERARHGRIVIADSDIAVEPDYLTRVTAPLADPSVGVVTCLYHARSVGGFWTRIGAQFVDAWFAPSVRITHLGGSSRFGFGATLALTRATLDAIGGFKALKDELADDYWLAELPRRLGLRTVLSEVNVATDVAEPSFAPLWLRETRWLRTIRSLNPAGFAFLFITFTAPWLVIGAALAAWLGPASAAGATAAWAAAIGTLARLALHARGAAGWRAFWRDLPLVPVRDALLALEWLAAAFGTQVVWRGARMTVVGGDARATVVEAGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD1</accession>
    <name>Q63SD1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisM</name>
        <name evidence="7" type="ordered locus">BPSL2393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524642.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108985.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2393"/>
    <dbReference type="EnsemblBacteria" id="CAH36395">
        <property type="protein sequence ID" value="CAH36395"/>
        <property type="gene ID" value="BPSL2393"/>
    </dbReference>
    <dbReference type="GeneID" id="56528794"/>
    <dbReference type="KEGG" id="bps:BPSL2393"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3008"/>
    <dbReference type="eggNOG" id="COG4160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESFLWPW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="26474" checksum="9E1EC807C7645F18" modified="2004-10-25" version="1">MIEILQEFGRAFLYWDGQRMSGLAVTLWLLVASLGAGFVCAVPLAVARVSKNRWLSTPVRFYTYVFRGTPLYVQLLLLYTGMYSLAFVREHAWLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRAIAHGEVEAARAYGMSPFTMYRRVILPSSLRRALPLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SX0</accession>
    <name>Q63SX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABBC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524778.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108796.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2201"/>
    <dbReference type="EnsemblBacteria" id="CAH36203">
        <property type="protein sequence ID" value="CAH36203"/>
        <property type="gene ID" value="BPSL2201"/>
    </dbReference>
    <dbReference type="GeneID" id="56528989"/>
    <dbReference type="KEGG" id="bps:BPSL2201"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3246"/>
    <dbReference type="eggNOG" id="COG4239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="155"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="40761" checksum="03AFA7C4522E4A82" modified="2004-10-25" version="1">MSRLAVSSRIDAARARVSPSPARRVWLRFKAQRLGYWSLVIFAIAFAASLAAPLWSNDKPLVVRYDGQFYFPLFKSYPETTFGGDFPTPADYLDPYVRGKLDAPGNFVLYPPNRYYYDTLNYFSKRPNPAPPSRENWLGTDAQGRDLLARLVYGFRVSVEFALILTFIGTLLGIAAGAVQGFFGGRIDIVGQRLIEIWSSMPELYLLIIFASVFEPSFVLLIVLLSLFGWIGLSDYVRAEFLRNRTQDYVRAARAMGLTNWQIIWRHVLPNSLTPVITFLPFRMSGAILALTSLDFLGLGVPPPTPSLGELLAQGKANLDAWWISLATFCVLVATLLLLTFMGDALRNALDTRIADTARAAGRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T49</accession>
    <name>Q63T49_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535997.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108717.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2120"/>
    <dbReference type="EnsemblBacteria" id="CAH36123">
        <property type="protein sequence ID" value="CAH36123"/>
        <property type="gene ID" value="BPSL2120"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2120"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2406"/>
    <dbReference type="eggNOG" id="COG1953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLVLLKF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="510" mass="55040" checksum="04E6E4E5FA2A4C4A" modified="2004-10-25" version="1">MTIARLVRGRQGDVMAQFSVARQSASYRPNEDRAGGPDGGAQMPAGYSSRLYNEDLAPLASQRWGAYNIFAFWMSDVHSVGGYVFAGSLFALGLTSWQVLVALIVGISIVNVLCNLIARPSQQLGVPYPVACRATFGVLGANVPAVIRGLIAIAWYGIQTYLASSALVIVVLKFFPHWMPYADVHRYGFLGLSALGWAGFMLLWVLQAFVFWNGMETIKKFIDFAGPAVYVVMFALAGYMVWRAGWRNIGLNLGGVRYHGAEVIPVMVTAISLVVSYFSGPMLNFGDFSRYCSSYGGVKRGNFWGLPVNFLAFSLVTVITTAATLPVFGELITDPVETVGRIDHPSAVILGALTFTIATIGINIVANFVSPAFDFSNVAPRLISWRAGGMLAAVASVFITPWNLFNNPAVIHYTLDVLGSFIGPLYGVLIVDFYLVKRGALRRDDLYTTSADGAYWYRDGVNRRAIAALLPAAAIAVACVMAPALSGLANFSWFIGAALGGAFYRALAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TC1</accession>
    <name>Q63TC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536040.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108645.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2047"/>
    <dbReference type="EnsemblBacteria" id="CAH36047">
        <property type="protein sequence ID" value="CAH36047"/>
        <property type="gene ID" value="BPSL2047"/>
    </dbReference>
    <dbReference type="GeneID" id="56526410"/>
    <dbReference type="KEGG" id="bps:BPSL2047"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2309"/>
    <dbReference type="eggNOG" id="COG3673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAWFKPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="DUF2235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="DUF2235"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2235" evidence="1">
        <location>
            <begin position="42"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2235" evidence="1">
        <location>
            <begin position="295"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="802" mass="88764" checksum="E9C41018ECD28611" modified="2004-10-25" version="1">MSYRFASADRFDVNVVTKDEQDAILRRLHEDDGMACCKTLHIGIFFDGTRNNADRDRGARTESNVARLYAAFPIDKYHQAIYVAGVGTPFVEQIGDFGVGLQAAAGAAAGWAGEGRINWALLRIHDILHAYVHGQTLTAVLGKRYEELVKSMSLDMNFKGIDLGGTPPKPGSFGDIKLRANSGVGALKLIAAEQNGVELTWDLDTNWAQLKNELDSSKWNAAVQEWDAKRRKVLLDRRAQLKARIGDLLVKGKPKLQRIRLYVFGFSRGAAEARTFSNWLADALDPDFSLCGVPVSYDFLGIFDTVASVGIAQSAAATLFDGHGGWGRKELMAVPHYVRRCVHMVAAHEPRGSFPLDLIDCSMDGREEIVYPGVHSDVGGGYGPGEQGRGRDDADKLSQVPLLDMYREARKAGVPLDINGPGIGADVIAAFKVSAGLKQAFAAYVKKSENYYYEKDHGTPGLMRCHYGLYLRWRKMRLKDMHAQPSFKAAQARYPQDAADLDSANAELKEEWNDLLEVEKAGGPTITRYVEKFVTKWASENPKTAAVVSTSLLPAAVAAEVFVPGVSAATVLFGDKVVKLVQAQLKEKWEQWLQVRSDWNMGPPEPAISALYDNYMHDSRAWFKPLGDDDDVWNHRQIQELKTKQASFERAHAAWKKRVEMGMPSLLQVTQAMGVGSTGWGPVGGLPPEPEPRSPLTAQQADLLKRYDAAMQSAKQARAAKDPNAPTDSAVLTDPKVTGGLALQTSGREFYFLWGFLRWRTVFVNGVRWDQPRVPTVQEEMEGMRMQMQRQVDMKGIGVLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TE7</accession>
    <name>Q63TE7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative drug-resistance related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521735.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108619.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2021"/>
    <dbReference type="EnsemblBacteria" id="CAH36020">
        <property type="protein sequence ID" value="CAH36020"/>
        <property type="gene ID" value="BPSL2021"/>
    </dbReference>
    <dbReference type="GeneID" id="56526387"/>
    <dbReference type="KEGG" id="bps:BPSL2021"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4181"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWIFWIS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="539" mass="58087" checksum="1AA4BED66CAEFD54" modified="2004-10-25" version="1">MNGSTPTPPAAPRRDRNGNGDGTWRPAANPWLIAVVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTLTSYLVANGIVLPISGFLGRLLGRKRYFVLCIVAFTICSFLCGIATDLGQLIVFRVLQGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAVAIVVAPVLGPTLGGWITDNFSWRWVFLLNVPIGVLTSLAVIQLVEDPPWKRGRARGLSIDYIGITLIAIGLGCLQVMLDRGEDEDWFASTFIRTFAVLTVAGLVGATFWLLYAKKPVVDLSCLKDRNFALGCVTIATFAVVLYGSAVLVPQLAQQRLGYTAMLAGLVLSPGALLITLEIPIVSKLMPYVQTRFLVCFGFLLLAASLVYSHTLVPDIDYPNLLKIRSAQSLAIGFLFVPITTLAYLTVPRRLNDDASALFTMFRNVAGSIGISLSTALIRERAQARMAHLSTHLSPLSQNFDDTLRQNAQTIASLSGMPPPAALQTASGQLYETFVSQATILAYLDVFAMLAIFCFVCTPLTLLFSPVKAAGGPGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH4</accession>
    <name>Q63TH4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191266.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108592.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1994"/>
    <dbReference type="EnsemblBacteria" id="CAH35993">
        <property type="protein sequence ID" value="CAH35993"/>
        <property type="gene ID" value="BPSL1994"/>
    </dbReference>
    <dbReference type="GeneID" id="56595403"/>
    <dbReference type="KEGG" id="bps:BPSL1994"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4146"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3892">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPLEHVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018659">
        <property type="entry name" value="DUF2090"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09863">
        <property type="entry name" value="DUF2090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="15"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2090" evidence="4">
        <location>
            <begin position="333"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="666" mass="72517" checksum="2922DC6F5425EDEC" modified="2004-10-25" version="1">MTSPTLSFAQNRPLDVICVGRVAVDLYAQQIGARLEDASSFAKYLGGSSGNIAFGCARLGLKSAMLSRVGHDHMGRFVRETLAREGCDTSRLRTDTERLTALVLLGLKDRDTFPLIFHRENCADMALDEDDFDEAFIASSKALLITGTHFSTEQVMRASRRALDYARRNQVRTVLDIDYRPVLWGLTGKADGETRFIANEGVTAHLQRILPLFDVVIGTEEEFRIAGGKDALLDALAMVRAVTSAALVVKRGPLGCSIVDGDVPATLDALPVIRGVEVDVMNVLGAGDAFASGFLSQWLRGRPFADAARAANACGALVVSRHGCSPAMPTPAELAYFLAEAKRDPARMRRPDLDATLARLHRVTPARTPRDEVLGFAFDHRNQFFELARQTGASVARIDALKRLFVEAVAQTEAQLGLAGRIGVLIDDRYGQDALNDATGRGWWVGRPVELPGSLPLEFDHGRSIGTTLASWPLEHVAKCLVQYHPDEAAEPRIEQETQLRALYDAVQASGHELLLEVIPPRRADLPQAADTVYRALKRLYNLGIHPEWWKLAPLDAAQWQAIDALIAERDPYCRGVVLLGLSAGVDELVGGFGAAAASATCRGFTVGRTIFHEPSRAWLAGEIDDAELIARVRRTFETLIGAWRAARTDARARGRHAGAAPRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TJ3</accession>
    <name>Q63TJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108573.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1975"/>
    <dbReference type="EnsemblBacteria" id="CAH35974">
        <property type="protein sequence ID" value="CAH35974"/>
        <property type="gene ID" value="BPSL1975"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1975"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2227"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTWVKLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="48"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="32811" checksum="232EA46154095688" modified="2004-10-25" version="1">MNRTMFLRKLFGFVATAVILIVAILIGRTLWVHYMDEPWTRDGRVRAEIVNVAPDVSGAVVELPVRDNQFVKQGDLVMQIDPSHFRIAVEQAQAAVAARRAELQMRRADAARRADLDALVVSKESRENSAQTASSAEAQYQQALAALDAAKLNLERTRVVAPVDGYVTNLQVFKGDYASAGQAKLAIVDSHSFWVYGYFEETKLPRVKIGAKAEMRLMSGGVLKGHVESISRGIYDRDNPQSRDLVADVNPTFNWVRLAQRVPVRIHIDEVPKDLVLSAGTTCTVIVEPDGGGKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TJ6</accession>
    <name>Q63TJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative antibiotic resistance membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108570.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1972"/>
    <dbReference type="EnsemblBacteria" id="CAH35971">
        <property type="protein sequence ID" value="CAH35971"/>
        <property type="gene ID" value="BPSL1972"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1972"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2224"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSMNYAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001442442" evidence="2">
        <location>
            <begin position="28"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="650" mass="65054" checksum="07E5E5D56D6E64E3" modified="2004-10-25" version="1">MQSPAMRGTLALAVLAISLIMAGCASMGDVAPQDKQVDPASLDAGAAIAAAERDAGWPAADWWRAYRDPQLDSWIAASLAGNPSLAAAQARVREAQSLARIAHAEELPQLNGNLSLMRQHWPDNVYYGPGPLANADTWNNTGTLSLSYHLDLWGKDKHNAERALDAARARAADARAAQLELEANVVRAYVDFAKNYALLDIAHATYERQNALAELARKRLRAGIGTQLEVSQAEAPLPDYSRQIDSYEEAIQLGRHQLAALAGKGPGAGASLARPKLALDANAALPSALPAELLGRRPDIVAARWMVDAQARGIDVAKAAFYPNVDLIASLGGFAVSAPFATFLRAMNGGWSAGPALTLPIFEGGRLRAQLGVASAGYDQAVEHYNQTIVGALKDIADNVVRLHSLDSQQKDAARAVSLTRRSYDLSHAGFSRGLTDYVNVLIAQSQLLTAQENQTRIEAARLAAHASLMVALGGGLETGRDAPHDAPAGDARRTGASGASGASRASRASRASGASGASGASGASGASGASGASGASGASGASGASGASGASGASGASGASGASGASGASGASGASSTAGASATASASAAGHAPAGAAAPASPAGIRAAASARASMPAPAAAATAPAFASPVAGASTPMPAATAAARAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U14</accession>
    <name>Q63U14_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">amrB</name>
        <name evidence="5" type="ordered locus">BPSL1803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
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    <dbReference type="SMR" id="Q63U14"/>
    <dbReference type="STRING" id="272560.BPSL1803"/>
    <dbReference type="EnsemblBacteria" id="CAH35802">
        <property type="protein sequence ID" value="CAH35802"/>
        <property type="gene ID" value="BPSL1803"/>
    </dbReference>
    <dbReference type="GeneID" id="56529490"/>
    <dbReference type="KEGG" id="bps:BPSL1803"/>
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    <dbReference type="OMA" id="MAETMAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="919"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1043" mass="111277" checksum="7F918F8270F0B701" modified="2004-10-25" version="1">MARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSLYATYPGASAQVVEESVTAVIEREMNGVPGLLYTSATSSAGQASLSLTFKQGVSADLAAVDVQNRLKIVEARLPEPVRRDGISIEKAADNAQIIVSLTSEDGRLSGVELGEYASANVLQALRRVEGVGKVQFWGAEYAMRIWPDPVKMAALGLTASDIASAVRAHNARVTIGDVGRSAVPDSAPIAATVLADAPLTTPDAFGAIALRARADGSTLYLRDVARIEFGGNDYNYPSFVNGKTATGMGIKLAPGSNAVATEKRVRATMEELAKFFPPGVKYQIPYETASFVRVSMSKVVTTLVEAGVLVFAVMFLFMQNFRATLIPTLVVPVALLGTFGAMLAAGFSINVLTMFGMVLAIGILVDDAIVVVENVERLMVEEKLPPYEATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFAFALAVSIGFSAFLALSLTPALCATLLKPVADDHHEKDGFFGWFNRFVARSTHRYTRRVGRVLERPLRWLVVYGALTAAAALLITKLPAAFLPDEDQGNFMVMVIRPQGTPLAETMQSVRRVEEYVRTHSPSAYTFALGGYNLYGEGPNGGMIFVTMKDWKERKRARDQVQAIIAEINAHFAGTPNTMVFAINMPALPDLGLTGGFDFRLQDRGGLGYGAFVAAREKLLAEGRKDPVLTDLMFAGTQDAPQLKLDIDRAKASALGVSMEEINATLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDAADVTKLRVRNAKGEMVPLAAFATLHWTMGPPQLTRYNGFPSFTINGAASAGHSSGEAMAAIERIASTLPAGTGYAWSGQSYEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVAGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFATGAASGAQIAIGTGVLGGVISATLFAIFLVPLFFVCVGRVFDVVPRRRGGAQAALEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U20</accession>
    <name>Q63U20_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL1797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108396.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1797"/>
    <dbReference type="EnsemblBacteria" id="CAH35796">
        <property type="protein sequence ID" value="CAH35796"/>
        <property type="gene ID" value="BPSL1797"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1797"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3911"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFKNEAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="28"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="346"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH35796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="587" mass="62922" checksum="37FC8A17128B190C" modified="2004-10-25" version="1">MKLAALRSLADVIRLMLDKETHARRPIVAGVLVEALTSAFMLLGPIALKLAVDEMARPRFDAAKASVDIALFAVLWSASAISSIALLAYTGRIVHAVSNALLRRALHAQLPALASRASSDSGYVQGLLERLPYSLQVIIEGVLWKIVPVAIQLAVALVLIALLVPLRYAAILFAVLAAYFVFSHLSAEQYEKSAATTNEAAGALSAALGDVLANAPRVVYNGALAREIDYVGARAGARLDVDWRRSWLLTRAAACQYGIIALGMAAMFVLCVRDIAAGRITLGDFMLLQTYVLQFALPLGAYGFVLRQAGAALANVREALDIAPRPAPTAAAIGAAPPPGRSGAPIAVRRLAFRRADRFAIEPMSFDLPAGSYTAIVGHNGSGKSTLAKIIAGRLAPDEGVVTYGDVDLYRVASDARHRFALYVPQDVALLNRSLRENVRYYPSTLTDDDAARLLERLAFHKDGRPIDLDGEVGEGGARLSGGQVQKVELVRLMGVDVPAIVLDETTSGLDPHSDALGIAMLRERLGQRTTLVLITHRIANVEAADQVLFLSGGRLVAAGPHRRLVDTCDEYRAFWRRQPEPADAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UE5</accession>
    <name>Q63UE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108271.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1660"/>
    <dbReference type="EnsemblBacteria" id="CAH35658">
        <property type="protein sequence ID" value="CAH35658"/>
        <property type="gene ID" value="BPSL1660"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1660"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1872"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIKQMLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="599" mass="65179" checksum="60AC1C57A53B5D35" modified="2004-10-25" version="1">MPRAVLSQGIEQSISRAEMQARIASAYYMAPRGREPIVPLPPAASGAPGQRAEHAAGLMTLEKMIALVGERDPRVLVSELSARAAHERAAKAWAGHYPQLSVEYALGREGNWNAQGGPTSLSSVNADNFHGGQVNLSWELYAWGATQKRYEEAYALAKAEEDRYRRAWDLIVMEAISTYVNMYRLRKQLEITRQTLLGHSKLLKVVEDRVGAKLAPESRRSDALLRVQEIMADREDILSQLNEVDTTYRTLTGLEPPADLAEPQLAKEYEAKLACLSFDDNLKLAYSIHPQIQANLRTIEAAAYAVEGMKAERLPKFNLYARYNNNRLFSTQGSTLPFTGRGYEIGVNVVWTLFGSAYGNSIAERIFLKEKSEADNERAVREVERNIHIARDALAAAKGRTAILDETLRLSDEVLNQRQHSFSVQAMSDEAVNGLSNAYYSRARAATALLNLHMREVVASYTLVESSGLMNEVFPAPLSVRGPIGPAPVRNFFPGRVAGMNPEDGMPLERNVMPDLLTRKVVLTDGMSTTAEPQSGTAPTPASSAGGVPASASDAATARSLEVPPVMLSPAREAPLDNGSPQPPAGDAQAPAAATGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UI3</accession>
    <name>Q63UI3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192100.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108233.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1617"/>
    <dbReference type="EnsemblBacteria" id="CAH35617">
        <property type="protein sequence ID" value="CAH35617"/>
        <property type="gene ID" value="BPSL1617"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1617"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3678"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPMAFNR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="480" mass="53224" checksum="0FD0637F0091360B" modified="2004-10-25" version="1">MHLPNRTQVLVIGGGPAGATGAAFLAREGVEVTLVDKEVFPRYHIGESLLPSCLEILTLMGARDTFDRHGFQRKPGAYFNWKGETWKLDFGELGGTYRYSYQVRREEFDHLLLQHARAVGAQVHEGVSVREILFDDGRPCAALCVAQGAEEATTVEFDYLVDASGRNGLMSTRYLDNRKFHEIFRNVAAWGYWEGLSWPDDCAPGSILVSSIPDGWWWAIPLADRPTSVGVVMHRDAFVAARRTGTLEQVYAQALALSPVMANLTEHARLVTPLKTEQDYSYTCDSFAGNGYFLSGDAACFLDPLLSTGVHLAMYSGMLAAASLASILRAEVTEREAAAYYRDSYRQAYLRFLVFVQTFYEAHGKLGYYSKADELSHYMIEAGDIRRAFLNLVSGLEDIADAEQATSHLMGEMSRRIDQNLALRKDKRALSSAIGSTQVEDNARFFDAIEGLPCLSANMALDGLYVSTRPRLGLQRVAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UL9</accession>
    <name>Q63UL9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-ketogluconate reductase</fullName>
            <ecNumber evidence="6">1.1.1.215</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tkrA</name>
        <name evidence="6" type="ordered locus">BPSL1577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.215" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521382.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108197.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1577"/>
    <dbReference type="EnsemblBacteria" id="CAH35578">
        <property type="protein sequence ID" value="CAH35578"/>
        <property type="gene ID" value="BPSL1577"/>
    </dbReference>
    <dbReference type="GeneID" id="56529302"/>
    <dbReference type="KEGG" id="bps:BPSL1577"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3628"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWHPTQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008873">
        <property type="term" value="F:gluconate 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="5"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="103"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="325" mass="34780" checksum="040D88178DA75C90" modified="2004-10-25" version="1">MKHRIVVYKPLPDDVLAALRARADVVLAEGADALARALPDADGALGASLRITPELLDRAPRLRAWSTISVGFDNFDVADLTRRGIVLAHTPDVLTEATADTVFALILASARRVVELAEYVKAGQWRQSIGEALYGTDVNGKTLGIVGLGRIGTALARRAALGFRMPVLYTSRSAHPQAEAQFGARRVELDELLATADFVCLQVPLSPQTRHLIGARELAKMKRDAILVNASRGPVVDEAALIDALRAGAIRAAGLDVFEHEPLAADSPLLSMRNVVALPHIGSATRETRHAMARCAAENVIAALDGTLARNIVNRDVLQRTPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UW0</accession>
    <name>Q63UW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108106.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1486"/>
    <dbReference type="EnsemblBacteria" id="CAH35487">
        <property type="protein sequence ID" value="CAH35487"/>
        <property type="gene ID" value="BPSL1486"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1486"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1669"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HPFHQKG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="231" mass="22434" checksum="B06E987661670D0B" modified="2004-10-25" version="1">MLERDARLAPRAGFVPTATHPFHQKGAPAMLKKLLMLVVALSLSLTAALAAAVEVNTADQAALESVKGLGPVKSKAIIDERAKNGPFKDADDLANRVKGLGAKSVAHLEAAGLTIGGSTTPPTGAKAKTGTAKPAATATPAPAPAPAPTTSSATPAPSAATPAPATATPSTAASAPAAKKSRSSKKQDKAAAASAAAQASAPAAASTTKAKGSKKSRKNKAATPASAASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UX9</accession>
    <name>Q63UX9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family C40 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205011.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108087.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1465"/>
    <dbReference type="EnsemblBacteria" id="CAH35467">
        <property type="protein sequence ID" value="CAH35467"/>
        <property type="gene ID" value="BPSL1465"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1465"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3496"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QIMRAST"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="404" mass="40180" checksum="B155EA49219ECB48" modified="2004-10-25" version="1">MLRLSLSVLVISLLAACSSVPPKSARSSSGMAITTPRAYAPPRGFPNFVDHSVGREEISIQAMSLVGVPYRWGGNTPDSGFDCSGLVRYVVDRAASVNLPRTTADMSSIGESIEPDGIAPGDLIFFNTSGRPHSHVGIYVGKLRFVNAPSTGGTVRLDYLTNPYWAKRFDGIRRVAAPKAKPAPFDAPTYQASRPPEPAPRVSPAAAAPAYAAVNAPAASAARAAAPSAPGYAANSATPAAARAAAPPPSSEYAAHSAAAMASAPASAAPLPNAVPAAATAATAADPYEPPPSAMSAARRQAQAAGARSPVLAAGNPGGAVPPAAPPAGGPTSMAGASAADPIDAAADAFEPPPPTARAAARQAQLAAPGNVQVLRASTAGSAASAAATGSNDDPIARFANGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UZ1</accession>
    <name>Q63UZ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521296.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108075.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1453"/>
    <dbReference type="EnsemblBacteria" id="CAH35455">
        <property type="protein sequence ID" value="CAH35455"/>
        <property type="gene ID" value="BPSL1453"/>
    </dbReference>
    <dbReference type="GeneID" id="56529178"/>
    <dbReference type="KEGG" id="bps:BPSL1453"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3480"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FIAVVEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="303" mass="34029" checksum="6C30FE7BE7227A27" modified="2004-10-25" version="1">MDRYKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSEDGAAFLERCRGLLTEWAQAENEVVAGRRAVGGHLIVSAPAAFGRKHVAPLAPAFVADKPDLQMSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLASNRRVVCGTPEYFRRHGRPRTLDDLASHNCLAFNLQGGQNRGWYFRRNGKLVTMRVSGTLDCNDGELLHRWVSEGLGLGWRSTWEIAQQLARGELETVLDEYALPDYDILAVYPQQRYVPARVRYFIDYLRDVYARPGYWEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V35</accession>
    <name>Q63V35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550296.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108031.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35411">
        <property type="protein sequence ID" value="CAH35411"/>
        <property type="gene ID" value="BPSL1409"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1409"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3427"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="70" mass="6986" checksum="A3410825B8141855" modified="2004-10-25" version="1">MHEAWRAGASDHEVLDAAGVAMMMGGESAVVYACPVYKALEQFSAAAAVPPDAVPLDAVLAGTASVGAPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V79</accession>
    <name>PSTB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate import ATP-binding protein PstB</fullName>
            <ecNumber evidence="1">7.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ABC phosphate transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-transporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pstB</name>
        <name type="synonym">phoT</name>
        <name type="ordered locus">BPSL1362</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:24440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193614.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107987.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V79"/>
    <dbReference type="SMR" id="Q63V79"/>
    <dbReference type="STRING" id="272560.BPSL1362"/>
    <dbReference type="EnsemblBacteria" id="CAH35360">
        <property type="protein sequence ID" value="CAH35360"/>
        <property type="gene ID" value="BPSL1362"/>
    </dbReference>
    <dbReference type="GeneID" id="56595289"/>
    <dbReference type="KEGG" id="bps:BPSL1362"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.118"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51238">
        <property type="entry name" value="PSTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092796" description="Phosphate import ATP-binding protein PstB">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="36"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01702"/>
        </source>
    </evidence>
    <sequence length="282" mass="31429" checksum="205CA8168A734F0D" modified="2004-10-25" version="1">MNMAESHLDPSKLATGPAGFGAAAGQRPLAPLNAKIEVKNLNFFYNQFHALKNINLSIPEGKVTAFIGPSGCGKSTLLRTFNKMYALYPEQRAEGEIVMDGENLLQSKLDISLLRARIGMVFQKPTPFPMSIYDNIAFGVKMFERLTRSEMDDRVEWALTKAALWNEVKDKLSQSGYGLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELIAELKSDYTVVIVTHNMQQAARCSDYTAYMYLGELIEFGETEKIFIKPARKETEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VB0</accession>
    <name>Q63VB0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative malonate decarboxylase beta-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191701.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107956.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63VB0"/>
    <dbReference type="STRING" id="272560.BPSL1331"/>
    <dbReference type="EnsemblBacteria" id="CAH35329">
        <property type="protein sequence ID" value="CAH35329"/>
        <property type="gene ID" value="BPSL1331"/>
    </dbReference>
    <dbReference type="GeneID" id="56595255"/>
    <dbReference type="KEGG" id="bps:BPSL1331"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.154"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGCFGGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044262">
        <property type="term" value="P:cellular carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017556">
        <property type="entry name" value="Malonate_beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03133">
        <property type="entry name" value="malonate_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="32493" checksum="60A6C29DC2EE7161" modified="2004-10-25" version="1">MNAAATTLHPKLAPAGASWFEASARQRLAGLVDAGSLDEFAGPPARLASPHLPLFDLPQQFDDGMIVGRATLAGEPVFVAAQEGRFMGGAFGEVHGAKLTGLLRAARELRAAPVLILFDTGGVRLQEANAGEIAVSEIVRAVIDARAAGVPVVGLVGGRAGCYGGGGIIAACCSALAVSEAGRIGVSGPEVIESRRGVDEFDSRDRALVWRTMGGKHRRLVGGADAFVDDTIDAFRHAAIALLARVRAGGAFGTATLEAEHARLAARIARFRDCDDALDVWRALGAPDAGAIPALDAAAFAALADRLTEVCDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VB9</accession>
    <name>Q63VB9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192748.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107947.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63VB9"/>
    <dbReference type="STRING" id="272560.BPSL1323"/>
    <dbReference type="EnsemblBacteria" id="CAH35320">
        <property type="protein sequence ID" value="CAH35320"/>
        <property type="gene ID" value="BPSL1323"/>
    </dbReference>
    <dbReference type="GeneID" id="56595245"/>
    <dbReference type="KEGG" id="bps:BPSL1323"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.165"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PMPLDAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="145" mass="15928" checksum="52062EF77430E6DA" modified="2004-10-25" version="1">MSDLYFGADLFSEFDRLHRQMANLFGGFPSSIRASRLGGFPALNVGTTEDSIEIVVFAPGMRAADFDVSIDKGLLAISGERKAAQRAEGEVRAYAQERFSGAFRRVVELPQNADPDKIRARYENGCLLISVGKREASKPRAITVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VG5</accession>
    <name>Q63VG5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204975.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107901.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35274">
        <property type="protein sequence ID" value="CAH35274"/>
        <property type="gene ID" value="BPSL1280"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1280"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.229"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVLIQYW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="12"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="454" mass="48277" checksum="49A258AF9FE1D8F7" modified="2004-10-25" version="1">MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALGEMAVREPVPGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPHVPQWIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAMIGGGAAILFTGMRLGSGGAPSLANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERAIPRAINAVPMRILLFYVLTMIVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDIFGAGRMMYAMALQGQAPRALAAMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAASATFATVWVWLMILLSQIAMRRRLGAAEVAALKFKVPFWPVGPALTIAFMAFVIAMLGYFDDTRVALFVGAAWLAILALVFYTRIRPRLAAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VI0</accession>
    <name>Q63VI0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107886.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1265"/>
    <dbReference type="EnsemblBacteria" id="CAH35259">
        <property type="protein sequence ID" value="CAH35259"/>
        <property type="gene ID" value="BPSL1265"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1265"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1400"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AKHYADR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="22160" checksum="7B25293D5C152714" modified="2004-10-25" version="1">MKVLLIGASGRTGRALADLLLKQQDFEVTALVRRPDFALPGAKVVVADLTGDFSSAFNGITHAIYAAGSAESEGATEEEQIDRDAVARAADYAKARNVQKLVVISSLSAYWPQSSPEFLRHYSQMKREGDERVIASGIDYVILRPGPLTDDPGVGKIALTEERLDDAPPVARQDVAWAAIEAIKLGISKKTIGFVGGSVPIEQALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W33</accession>
    <name>Q63W33_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552395.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107683.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1060"/>
    <dbReference type="EnsemblBacteria" id="CAH35055">
        <property type="protein sequence ID" value="CAH35055"/>
        <property type="gene ID" value="BPSL1060"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1060"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1152"/>
    <dbReference type="OMA" id="WPPSENA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="100" mass="11247" checksum="29EA713B25359302" modified="2004-10-25" version="1">MARNRVSAEIAVRMDEIPRWHGAWTSCLPVLYWPPSENASNCRYCVFLTFRVVRALFIGARARVRFGLMAGNVGGTPAWRLPFAQAPHLQDTPSETATRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WE5</accession>
    <name>Q63WE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107571.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0942"/>
    <dbReference type="EnsemblBacteria" id="CAH34938">
        <property type="protein sequence ID" value="CAH34938"/>
        <property type="gene ID" value="BPSL0942"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0942"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1025"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="733" mass="80929" checksum="1E717721EF3B55D8" modified="2004-10-25" version="1">MPIRNLESSGAVARLNSVRLDVNIEEAAVQLARWEASRDSLIVPVSIDLRQFAEMAKAAGGGELAPDFYKDRARYVRQHIAGELGLDEYAASRLTFTMTKSDAWYLGPKPKLNRESMIAAVRAHPEKFVELMLQRELLEAAAYDSEQTFVTGGFGPGVYLGSLPKADARRLYLAEAKFRIRSKYQQIVCDFIAKAFTRKKASKGNTSAETLVAEAGNGFLFGVTRIVPSQFFEEDARKYPMTGISLDSGKFRQTRLYYLNILTEFALSLFDRASVRASAETFVATHCVDDGYIPLEPLAELKRPLIVVNATEQQLTEEALAPLKRIPEFFPKWTSSIGERAHFTARSVTGVAAAPAQLSKEKNYLFLNGEVELGETSIRLASKADGLTQAKAATASAAYNKLAEGDSVADAYTERKFAQLMEQETYVVAMQGLDYGPVSLEKLLPGRSGDVTLQEALKRCLVELSLKECLLGQKLVPTPSMPEELRSGHLTLLATRRIFQQGGRKAKQLVACVGVELTADGIAVRSTERSPWSRDTAAALDFVDRFPFLQPDGKQMIEDGQFWLVDPTTGERLTAWWGEFVPRIILNSTYPSIESALAAQEPGLQRRREAGETARYYSKGRDFNMLPYYMSMYSPDHQVRGEKTGTKIALQDCGGFVRTFVPPAGGIVGTGDTLSGMRDVMVYGGDGKPKEGDLLDHRLVQVYLHTLTNGVLVAGDNSKMSILEKLVRLALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WE6</accession>
    <name>Q63WE6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552966.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107570.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0941"/>
    <dbReference type="EnsemblBacteria" id="CAH34937">
        <property type="protein sequence ID" value="CAH34937"/>
        <property type="gene ID" value="BPSL0941"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0941"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.637"/>
    <dbReference type="eggNOG" id="ENOG5032Y1S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1369" mass="156140" checksum="BA818F5BA4785DF2" modified="2004-10-25" version="1">MSRQQKRSETDILNRGFREPFLLAGDCPFIKHLNWFTGFGKTYTAAFFSLELFLKYRVVPVFIAPMQSLVKGFVDDVRKQSASKRENDEVSRFLKERGRDVPIYLLYSRDYHRNDRTFFEAVLKLYDWLVQNREVLSMVEVEVARERSAASKSNVSEMRRRANICLTSSFHDVAPGDDTYEDAKAAYFKATSSALSSADGVIRRLITLSVDRAADSRWRDVLQVPPVAEMVRRLQPLQAFLKDPGVIAGTASKSQVQQQLYAFDPERGCNRWFKFETLADFLAEINREGSVLGRSISGTSVPARAVVFLDEEEDAYWYQFDSRRSVVNAAGRHDLNVVITEFFAFLDFRWPIAFEKSSDNYTLASKVYQNLEMFASVAPAVWREYAVEASSKKAQHIPDQRRVEILRAKLIESFPGGEADDWSDSELLEVLHRLLDRNDGYKDFEKFRLKANILADFRTYVASLGGLTGYSQYREFKRVRALVVDKKYFTMSRSSYGEVLDQPSQTFFSAEASVMDTAFLRRVELSEDTAGQTIRLEYHQSDVPESAYTLFNYLQLVLFIAGRLNVESGEKEITFSPDDHERYPNLVRFRGEVRKLFSNKNTKGGFENDTFADQLLTDDFFFGGTKSVVTLEESRWKAEEYNLPADINLTATITSLLDTPETDVLKALGRNNGVYLMSATGGLIEASSGAFNMGELRRGILARGGQYERMTDAETDIVSERADNYLARRERCIQIIDDDSPVSSFEPSGGFNGLQQFVHEAFPAKGEFGYAPLNTYKRHEIDGLVATLDKLLSTELRSGLVLTQTVQRIRPILQKLSGNPATGIRQVDDDGHHFVIAPVLPFYRKSGNREPVTLILYTAARFRRRDPKEIGTVHETDDAGQFSQELINALDITEHKVLLWSAYGSASRGLDFVTTDKGMRKDFELFCLLNDPYYTHHTRPGERGFSMEMFQSYLQVVRDTEDGWPAMSRRDVLYDYSRNRWRRLRKEHYIDITRTLFQALGRGERCPEAKMPPQYIYVSSRAAQMVHLGTRCAPELVSRASPAQRALLRAIAARNLDMQLFDDDNVRRQHVTDSLKRAVALREFTSDTPARFRSSDSARQLWTRLFSPSMFTDPASYLETLRTAGVTSAFVDSAFQRVRRRVDLYTREVSRVGVTESILTDSFDGTDVYNWVEMLAPPGLLEKIGSVGKALAKGRNGFLVSATDNAERLFPQPWFVTEIMKGYLAELEFERFVEQQFGVTVESNAGAGPIRFIDMRNHPLEADIFQVYDYYLEVADSDVIVAVDVKNWARITDRLKKDELEAEAVAKHQRISQIFKGRTVRAVYLNLHGAHKYHVQHSAEGGIRFMSLYVHPADTWIYNDNLVGVLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WL1</accession>
    <name>Q63WL1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodB</name>
        <name evidence="9" type="ordered locus">BPSL0880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185841.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107505.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0880"/>
    <dbReference type="EnsemblBacteria" id="CAH34872">
        <property type="protein sequence ID" value="CAH34872"/>
        <property type="gene ID" value="BPSL0880"/>
    </dbReference>
    <dbReference type="GeneID" id="56594744"/>
    <dbReference type="KEGG" id="bps:BPSL0880"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.715"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
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    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="89"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="192" mass="21144" checksum="21741F7034DBAE59" modified="2004-10-25" version="1">MAHTLPPLPYAEDALAPHISQETIQFHYGKHHQAYVTNLNNLIPGTEFENLPLEEIVKKSSGGIFNNAAQIWNHTFFWNSLSPNGGGAPTGALGDAINAKWGSFDAFKEAFTKAAVGTFGSGWAWLVKKADGSLDIVSTSNAATPLTTADKPLVTIDVWEHAYYIDYRNARPKFVEAFWNIVNWDFAAKNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WN9</accession>
    <name>Q63WN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0852"/>
    <dbReference type="EnsemblBacteria" id="CAH34844">
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        <property type="gene ID" value="BPSL0852"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0852"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.920"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
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        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="387" mass="40914" checksum="4128C59B970FCDF8" modified="2004-10-25" version="1">MAGTVGDANDAGDRADPADSADPGVPDDPADPDDPPEPAATPALPGFDAPPAAAPKKRTRRRGVAPAAIADDVAAAARELPPHVRLGTSSWYFPGWKDIVYGDDYAQSKLSREGLEAYAAHPLLKSVSLDRSFYAPLTVANYLRYAQQVPDDFRFVVKAPALVTDAVLRGARGEPSGPNPAFLNAQLAADEFVRPCLEGLGNKAGALVFQFPPLPDTLLADPAALVDRLSTFLGALPALPAAPDGPRYAVEIRDASLLTPRFIRALAAAGVRYCVGLHAKMPDPLRQAAALALLDGEPSGPLIVRWSLHGGFKYEQAKAKYEPFDRLVDEDPHTRTALAELAARYVLAGQPVLITVNNKAEGSAPLSCIALAKEIAAACVRWRGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WV1</accession>
    <name>Q63WV1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0790"/>
    <dbReference type="EnsemblBacteria" id="CAH34782">
        <property type="protein sequence ID" value="CAH34782"/>
        <property type="gene ID" value="BPSL0790"/>
    </dbReference>
    <dbReference type="GeneID" id="56596576"/>
    <dbReference type="GeneID" id="66546193"/>
    <dbReference type="KEGG" id="bps:BPSL0790"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.815"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HIHASPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="16546" checksum="37C95964C9CA413E" modified="2004-10-25" version="1">MPRFARLFEAAADTLNAYYQAVADANLDALMVLWIDEDFASCIWSDGTHLHGLEQIRSGFGARLSTQPVTIEPLDIRVYDSLGTVVYTVAEAHQQADLTAEPQMVFTTYVMIHERGEWRIAHIHASPIPEQTATQFAAKIRHAQGPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X43</accession>
    <name>Q63X43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189665.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107323.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0694"/>
    <dbReference type="EnsemblBacteria" id="CAH34687">
        <property type="protein sequence ID" value="CAH34687"/>
        <property type="gene ID" value="BPSL0694"/>
    </dbReference>
    <dbReference type="GeneID" id="56596610"/>
    <dbReference type="KEGG" id="bps:BPSL0694"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.923"/>
    <dbReference type="eggNOG" id="ENOG5032TVI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EQWTFDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="166" mass="17862" checksum="A7FC5F32907F119D" modified="2004-10-25" version="1">MTDPDRRTLERTTYDAWPRAARALFDGGDLAGKAGFTASLVVVDRGVDPPQPRTTLLSVGELYAPDARSLRFSLWPQSRAARALAAHPDATLAFVAGDAFHQARLRVDSSDSTEDGLARFAATLVGGEAQRVGYARLTAGIAFELAEADAPAVLARWARQVAQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XJ3</accession>
    <name>Q63XJ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ordered locus">BPSL0547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534302.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107172.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0547"/>
    <dbReference type="EnsemblBacteria" id="CAH34536">
        <property type="protein sequence ID" value="CAH34536"/>
        <property type="gene ID" value="BPSL0547"/>
    </dbReference>
    <dbReference type="GeneID" id="56527207"/>
    <dbReference type="KEGG" id="bps:BPSL0547"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1100"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="2">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="184" mass="18719" checksum="7483EC0C05C8F1EC" modified="2004-10-25" version="1">MASVNKVILVGNLGADPEVRYLPSGDAVANIRLATTDRYKDKASGEFKEMTEWHRVAFFGRLAEIVNEYLKKGSSVYIEGRIRTRKWQGQDGQDRYSTEIVADQMQMLGGRGGSGGGGGGGDDGGYGGGGGGYGGGRDMERGGGGGRASGGGGAGARSGGGGGASRPSAPAGGGFDEMDDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XV1</accession>
    <name>Q63XV1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptsH</name>
        <name evidence="5" type="ordered locus">BPSL0439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198013.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107064.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0439"/>
    <dbReference type="EnsemblBacteria" id="CAH34427">
        <property type="protein sequence ID" value="CAH34427"/>
        <property type="gene ID" value="BPSL0439"/>
    </dbReference>
    <dbReference type="GeneID" id="56594468"/>
    <dbReference type="KEGG" id="bps:BPSL0439"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1220"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIMAMMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="89" mass="9646" checksum="3762635369610F39" modified="2004-10-25" version="1">MLQQETTIVNKLGLHARASAKLTQLAGNFQAEVWMTRNGRRINAKSIMGVMMLAAGIGSTVTIETEGPDEREAMDALLKLIADKFGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XW4</accession>
    <name>Q63XW4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dctB</name>
        <name evidence="13" type="ordered locus">BPSL0426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204799.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107051.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0426"/>
    <dbReference type="EnsemblBacteria" id="CAH34414">
        <property type="protein sequence ID" value="CAH34414"/>
        <property type="gene ID" value="BPSL0426"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0426"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.478"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRFRATR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dCache_1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017055">
        <property type="entry name" value="Sig_transdc_His_kinase_DctB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036431">
        <property type="entry name" value="STHK_DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="439"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="677" mass="73382" checksum="1A20B34583F27E16" modified="2004-10-25" version="1">MNAETAGRAAAPAPGGAGPDATRRAWPGPAAFSGGGYATIDDPYSPEAVTVKRRLLVVLALAAMLAAACALTWTLTWQSGIADLRDSAAARVDRTTNALKSTLDRYESLPYLLGGHPFVQDVLADPANRRQVNRANAYLEDMNRHAHATATYVITASGLCVAASNWRGPDSFTGIGYQFRPYFIDAVKGGTGRFFGIGTISRDPGYYISQPVRRDGKIIGVAVVKLNLEWFQGADASEPLVVADDHGVIFLSSVPQWKYHTLKPLPGPIATSIHETRQYAHYPVTPLPLRVERVLGPDAQIVRMGAARRAPRYLATRRLLGEPDWQLVTLAPIEPVDADARNATIVTAFGFVSLSLLAFYWRTRRARVKEMLRSRVLLQSAYAELNRRVEERTADLSQANARLKKEVGERIRAEQELRAAHDELVQASKLAALGQMAAGITHELNQPLAALRSFSDNTRVLLDRGEQAAARENLEAIAALTERMGKITNQLKLFVGRAKPRNERAHVARALRNVLALLKERMKDVELVITLRDETRDPAAAARFDPSRDAPALIARCEDLRLEQVLINLLGNALDAVAAVAAPRIDVAIDATAATLAITVRDNGPGIAPESLARLFEPFFTTKEMGRGLGLGLAISSSIARDAGGSLTARNAPAGGAEFVLTLRRARTHHPDTSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XX8</accession>
    <name>Q63XX8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189368.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107037.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0411"/>
    <dbReference type="EnsemblBacteria" id="CAH34399">
        <property type="protein sequence ID" value="CAH34399"/>
        <property type="gene ID" value="BPSL0411"/>
    </dbReference>
    <dbReference type="GeneID" id="56594323"/>
    <dbReference type="KEGG" id="bps:BPSL0411"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1252"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMSRQLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="321" mass="35549" checksum="33F23E30FD3AF1E3" modified="2004-10-25" version="1">MNIHRLPMLNALRVFEAAARHESFSRAADELSVTHGAVSHQMRALEAELGVPLFVRHGKRLALTDAGGRYAQQVRAALALLADATREVRASERDKRLVVSTLPSFAARWITPRIGPFIERHPEIDLELRASDSLVDFARDDVDVAIRFGHGVYPGLHVEPLLDETFFPVCAPTLNGGMLPETPADLVRYPLLRSDDELWRPWFDAAGLDTLTEPKRGVLYQDSSNLLQAAIDGQGIALVRRSLAVPEVAAGRIVRLFDIAGPSPWHYFFVCPPSLAQTPRVQALRSWLLDEIARFRALCAAQEAQHTAAYAAARARGKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y19</accession>
    <name>Q63Y19_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522956.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106996.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0370"/>
    <dbReference type="EnsemblBacteria" id="CAH34358">
        <property type="protein sequence ID" value="CAH34358"/>
        <property type="gene ID" value="BPSL0370"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0370"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1299"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIGLEYC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="225" mass="23399" checksum="CA3F9CD9C08A5CDF" modified="2004-10-25" version="1">MKTVLIVGASRGIGREFVGQYLHDGWRVIATARDAAALAALDALGARALALDVAQPDDIAAFDARLGGAALDAAVVVSGVYGPRTAGVEPIGVEDFDAVMHTNVLGPMLLMPILLPRVEASRGVLAVLSSKMGSIGEATGTTGWLYRASKAAVNDALRIASLQARHAACIALHPGWVRTDMGGAQAALDPQASVAGMRRVIAQAAGDRERANGRFFQYDGVELGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y76</accession>
    <name>Q63Y76_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="synonym">glmS1</name>
        <name evidence="11" type="ordered locus">BPSL0312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189813.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106939.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0312"/>
    <dbReference type="EnsemblBacteria" id="CAH34301">
        <property type="protein sequence ID" value="CAH34301"/>
        <property type="gene ID" value="BPSL0312"/>
    </dbReference>
    <dbReference type="GeneID" id="56594652"/>
    <dbReference type="KEGG" id="bps:BPSL0312"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1376"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSYYSGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="459"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="610" mass="65861" checksum="535B051761280F0E" modified="2004-10-25" version="1">MCGIVGAVAQRNIVPVLIEGLRRLEYRGYDSCGVAVLDAGAPAPGTPKRARSVARVADLDAQVRESHLEGETGIAHTRWATHGAPVTHNAHPIFSSDALALVHNGIIENFEPLREALRAKGYAFVSQTDTEVIAHLIHSLYRGNLFAAVQQAVKQLHGAYAIAVTHKDEPHTVVGARQGSPLVVGFGERENFLASDALALAGSTDRFTFLEEGDVCELTLEGVTVVDRDGARAARDVRVVAAYGGAVELGPYRHFMQKEIFEQPRAIADTIAQTDAFDPPLFGERASSVFAGIDSLLILACGTSYYSGLTAKYWLESIAKIPTQVEIASEYRYRESVPNPRALVVVISQSGETADTLAALKHAQALGHAHTLAICNVATSAMVRQTELQFLTHAGTEIGVASTKAFTTQLVALFVLAATLGKLRGHVDAAREADYLKQLRHLPAALNSVLALEPQIIAWSDEFARKENALFLGRGLHYPISLEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDTLLEKLKSNMQEVRARGGELYVFADADTHIVNDEGLHVIRMPEHYGPLSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y81</accession>
    <name>Q63Y81_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550314.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106934.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0307"/>
    <dbReference type="EnsemblBacteria" id="CAH34296">
        <property type="protein sequence ID" value="CAH34296"/>
        <property type="gene ID" value="BPSL0307"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0307"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1382"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REGMTMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267691" evidence="3">
        <location>
            <begin position="35"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="433" mass="46799" checksum="020BB9C6D233F629" modified="2004-10-25" version="1">MYSMLRAPHGRRARLHARTLVAALTFANAAAAFAQSAPLTLDAALQSAADRSAAMQAAQASVQASAELAVKAGQLPDPMLKAGIDNLPVDGPQRLTIGQESMTMRRIGIAQEWVSGDKRRLRTALANEVVGRERAGYLAQLADVRRQTAIAWLDAAYAKKALALQRELADEMNRELAATQAAYRGAKATAADALQARALLAQARDRQANARQAFDTALIGLSRWVAAPALDVAGEPPAPVSFVPSLPPDELRRVQPTLIAADEDVEVADADVALAASERRPNWTWEIAYQQRGAPYANMVSIGVTIPLPLDRRDRQDRDVAQKRALATKARLMYEDARRQVDADIRTQSATLESGRARLAELGRALLPAADERVRLADAAYRTGAGSLADAFAARRARLDARLQVLDLERDVARAWAQLDYQIVPSAMLAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y89</accession>
    <name>Q63Y89_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106926.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0299"/>
    <dbReference type="EnsemblBacteria" id="CAH34288">
        <property type="protein sequence ID" value="CAH34288"/>
        <property type="gene ID" value="BPSL0299"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0299"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.326"/>
    <dbReference type="eggNOG" id="ENOG50316RG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWGWTIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="22394" checksum="610865B1B6867FA7" modified="2004-10-25" version="1">MAARAARAAGARTSAPAVRINRRTAPRSSVRGTDNKTRTETEVDMFQMLPSMTFGRRLSVWWSCMWRQTLASAPVWILGVAIVGLSISRTHSAAGRPPSGGAAALAVATFFVCLVVCLPIAGYMVRGGFAAHALTAPERLAFRQALMVGLTTFGWAVLAALPISVATMPLRHAGYPLAGQAIGWVLNVAAGLYIVLPRQARRLRLLAGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YE3</accession>
    <name>Q63YE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106872.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0245"/>
    <dbReference type="EnsemblBacteria" id="CAH34233">
        <property type="protein sequence ID" value="CAH34233"/>
        <property type="gene ID" value="BPSL0245"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0245"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.262"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PILNRMN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="PTHR43718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="105"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="36312" checksum="9CED20C8F847C4C9" modified="2004-10-25" version="1">MGGSKARCAMTTAMVKQELAVASFSTVYDIERIETALNDLNEGASDALRATYEKMLKTGNLRFCVKPTRMPAFDSLAQALPNFAEPLDDVRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNGCYSNPVIAIDEIDKAGSDAQYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIEPPDASGARRIAQTIYGEIRNAHAWGQRFPAALGDDALDVLAAMPPRTMRRVLLHAFGAARLDGRDAVAPRDIRTDESAGRRRPIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YL4</accession>
    <name>Q63YL4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phage portal vertex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phage portal family. PBSX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204766.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106801.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0173"/>
    <dbReference type="EnsemblBacteria" id="CAH34160">
        <property type="protein sequence ID" value="CAH34160"/>
        <property type="gene ID" value="BPSL0173"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0173"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1549"/>
    <dbReference type="eggNOG" id="COG4695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHQEIYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030935">
        <property type="entry name" value="PBSX_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006430">
        <property type="entry name" value="Phage_portal_PBSX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018494">
        <property type="entry name" value="PBSX_VPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01540">
        <property type="entry name" value="portal_PBSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="39441" checksum="BB5D1A854843ED6A" modified="2004-10-25" version="1">MSKRRSRAPRTLAAAPNPSAGSAAPARAEVFTFDDPTPVMNRAEILDYVECWSNGEWFEPPVSFAGLAKSFRASTHHSSALFFKANVLASTFRPHRWLSRHAFERWALDFLTFGNGYLERRRNMVGGTLRLEPALAKYVRRKADFSGFVYVNGWQERHEFAPDSVFQLVRPDINQEVYGLPEYLSSLHSAWLNESSTLFRRKYYENGSHAGFILYMTDAAQKQDDVDNMRDALKNAKGPGNFRNVFMYAPGGKKDGIQLIPVSEVAAKDEFFNIKNVTRDDLLAAHRVPPQLLGIVPSNSGGFGTPDTAARVFGRNEIRPLQARFAELNDWLGDEVVTFDDYEIPPAPVAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z36</accession>
    <name>GCS2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="1">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="1">GCS 2</shortName>
            <shortName evidence="1">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL0001</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195787.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106626.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Z36"/>
    <dbReference type="SMR" id="Q63Z36"/>
    <dbReference type="STRING" id="272560.BPSL0001"/>
    <dbReference type="EnsemblBacteria" id="CAH33984">
        <property type="protein sequence ID" value="CAH33984"/>
        <property type="gene ID" value="BPSL0001"/>
    </dbReference>
    <dbReference type="GeneID" id="56593934"/>
    <dbReference type="KEGG" id="bps:BPSL0001"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1749"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIFGLHV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000218190" description="Putative glutamate--cysteine ligase 2">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <sequence length="371" mass="41779" checksum="B6FD7D66D7FE277F" modified="2004-10-25" version="1">MALETFVNSEPFTFGVELEIQIVNTHNYDLTKAASDLMRLIKDAKFPGNITPEITESMIELSTGICRTHDQALGELHAIRDTLVSAADQLNVGLCGGGTHAFQQWSERQIFDAPRFQYISELYGYLAKQFTVFGQHVHIGCPDADSALFLLHSMSRFIPHFIALSASSPYVQNVDTGFHSARLNSVFAFPLSGRAPFVLTWHGFEEYFTKMVNTGVVNSMKDFYWDIRPKPGYGTIEVRVMDTPLSVDRAAAIACYIQTLARYLLIDRPLKLSEDDYLVYTFNRFEACRFGLEGTCVNPQTGERRTIAEDILDTLDRIAPHAAALGSRAALDEIGALAKARVNDASWLRTIFKQEKSLNETVRQQCLRWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H7C784</accession>
    <name>H7C784_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195287.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107095.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0469"/>
    <dbReference type="EnsemblBacteria" id="CAH34458">
        <property type="protein sequence ID" value="CAH34458"/>
        <property type="gene ID" value="BPSL0469"/>
    </dbReference>
    <dbReference type="GeneID" id="56593834"/>
    <dbReference type="KEGG" id="bps:BPSL0469"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1186"/>
    <dbReference type="eggNOG" id="COG1101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMLHQGN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="28881" checksum="BE875D25879FD4EE" modified="2012-04-18" version="1">MLSAQDLKLTFNPGTPIETRALRGLSLDIPDGQFVTVIGSNGAGKSTFLNSVSGDQPVDSGRIAIDGVDVTRKPAWDRAPLVARVFQDPMAGTCEALTIEENMSLAMARGARRGFLPALNRASRELFRDKLRLLNLGLENRLTDRIGLLSGGQRQAVSLLMASLRPSRILLLDEHTAALDPKTAAFVLELTARIVDESKLTTMMVTHSMRQALDYGDRTVMLHQGQVVLDVAGDERRGLDVPDLLQLFEKTRHEKLDDDALLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HR9</accession>
    <name>Q63HR9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194498.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112353.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2350"/>
    <dbReference type="EnsemblBacteria" id="CAH39837">
        <property type="protein sequence ID" value="CAH39837"/>
        <property type="gene ID" value="BPSS2350"/>
    </dbReference>
    <dbReference type="GeneID" id="56598466"/>
    <dbReference type="KEGG" id="bps:BPSS2350"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5993"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVGRYHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="39744" checksum="8171C499A04822AE" modified="2004-10-25" version="1">MKPSQFAKGFQARPDITTSEKRTALDRLNAIDGLVKSEAAAPAAPPSKSSKKNLPVTIVETPPTADAADESSQYRSWRIDNRYQPGQVIELPLKAIKPSPFNPRHFYLKSSIAELAVNLAKQGQQQAIHVIPDYDNPGSYFVSDGGRRVRALKEANKESVKAIVVDLPIGIQSYKLGYDLNVQRDSQTVFDNAIVWKRFLEEKYFQSQKELAEHLGLDESTVAVALSIGKLPEAVMQEMVARPDRFGSNMAYQVGRYHAARGTDSTLRLINKILSDDLSTRQVADIVKGRATTQESPKPASRQRYAQRHEIKLNGVSVGDLKSYGEDRLELRLRGLTREKRDEILQQLERMLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I88</accession>
    <name>Q63I88_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205740.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112184.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2182"/>
    <dbReference type="EnsemblBacteria" id="CAH39667">
        <property type="protein sequence ID" value="CAH39667"/>
        <property type="gene ID" value="BPSS2182"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2182"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5763"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLRMWTY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="39445" checksum="2D88442D1AD11959" modified="2004-10-25" version="1">MRDQIDIPLISLVVPFYNEGDAVTRFFAEVMPLMEAIESIRFEIVCVNDGSRDDTLEQLVAVGAREPRVRVIDLTRNFGKEAALTAGLDEANGDAVIPIDADLQDPPSLIPVMIDHWRDGAEVVAAKRSNRACDTFAKRTAAALYYRVHNALSEVKLPVNVGDFRLMDRQVVNALRSLPERRRFMKGLFAWVGYRTVIVEYQREARCAGHSKFSGWKLWNFALEGITSFSTVPLRSWTYIGLGIAALAFLYGGFIVARTLWLGNQVPGYASLISVMLFIGGIELVGIGVVGEYIGRIYYESKERPIYLVRRRYQARTKVSALPVGAAATRVAHGARAEFARRRAMPRARADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE0</accession>
    <name>Q63IE0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS2131b</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112132.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2131b"/>
    <dbReference type="EnsemblBacteria" id="CAH39614">
        <property type="protein sequence ID" value="CAH39614"/>
        <property type="gene ID" value="BPSS2131b"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2131b"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6532"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266293" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20122" checksum="67B769E5DBFF57ED" modified="2004-10-25" version="1">MSNAKALSVASASASASPALPASSASTTSAASTASVASAASVERRNWYDDPFWALSHSIAECPTPLGPLMTRAQMEDDAHYRVERGTTCWLAHRCSKPNAYLYDKPIAGELKKRFADGDPALAGTSIWITIQRRFVYAEGCVSASFDRDALRRRLEALPDVERVFLRLTDDPRGRAPYKTLVAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63II8</accession>
    <name>Q63II8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112084.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2083"/>
    <dbReference type="EnsemblBacteria" id="CAH39563">
        <property type="protein sequence ID" value="CAH39563"/>
        <property type="gene ID" value="BPSS2083"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2083"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6471"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPMIRRS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="317" mass="35732" checksum="82177D8F309429DB" modified="2004-10-25" version="1">MLRRFGIGGHVQFTATSIKLSPTTFWERHQRVIAPWLFLAPALTLFAVYVVAPIIRSIGFGFYSWDGLSTSHFIGFGNYFELYDDPNFWIALENNFIWLACFLLAVPAGLFFALFLNQNVFGMRAVKSLFFFPFVISQAVVGLVFGWFYDPSNGLLFHVLQWFGVTPVAVLSDERYVTYGIVVAGLYPQISYCMILYLTGLSNVRPDLIEAARLEGAQGWRMLWSIVLPQMRSATFVSIVVTVVGALRSFDMVSIMTQGGPYGSSRVLAYYMYEQALGDYGYRVGYGSAIASILFLIMLTYIGFVLVRVYKQERGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ1</accession>
    <name>Q63IJ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205729.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112081.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2080"/>
    <dbReference type="EnsemblBacteria" id="CAH39560">
        <property type="protein sequence ID" value="CAH39560"/>
        <property type="gene ID" value="BPSS2080"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2080"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6467"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RCAYYSR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="677" mass="74727" checksum="AB7ED34E0D563BD6" modified="2004-10-25" version="1">MASRDRLNLGTAVQPLTLRSRNMNAGSKRFQHVASSKSSGNAETASNSRTKGSARFKPKALVVAMSISGLLFGYQGEVFAELTAISSEPAPATDQGNLASGFNAAVTEARSLVFNQTNYTRLWNENPSWATNNWPDGKTLSCPNPNTNPTLSPGYLASLYNRCAYYSRDYVHQATGAYYLGLYDENYTMANKFATTYHENGGVNAPWWAISVIGKPYEQRDELPAPFELGENIANMYRLTADNRYLGQDFQNYISQMTSYVKANSTVGSTTGTSLNPDGFRMARTQNGETASYNEFLPDNMQLLLGGDLAASQIAYYRAIKDNPTLIAKALSDNPSLRSTYFSDNYRNLASKFDQNWYITSTTSNPSTTCASPYSPPSAFSPFIPHFAVGQVGTPGTFYSSNSNPNYSSLTYDDAYIREPNIFPLYKNIITDSSKMDNQARYVDQLEEANYICANKQIDKPGIEYHTYLPTSFYNANMPDKAWKWLTRLAKWQSSSTKRDSQGNIIGYNAYPEVSFVLISDTITKVLGLDYDAPNSVLSTKSGLPSSFAPGNYVTIKNIPIYNKAKNTTINVDVTQKINSNGATQTDLAFVTDLSTVAFNQGFHWAPKFYNPTGNQYCKITRTYRNGGSDNTFVNVMTDSTTKISTCQDGTNIGIWVYTGQGANISSYSATLSSTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IT0</accession>
    <name>Q63IT0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111992.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1986"/>
    <dbReference type="EnsemblBacteria" id="CAH39464">
        <property type="protein sequence ID" value="CAH39464"/>
        <property type="gene ID" value="BPSS1986"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1986"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6360"/>
    <dbReference type="OMA" id="DACINLQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="27637" checksum="C84954DD87784242" modified="2004-10-25" version="1">MWRGFRSPTLDYEQFAQFLGSVFVPACVLLQPPVGLRAYLPTMMPQAGKPAAVPDQTALIFWATPASHDRAMKALAVRIYQNLHGDVYDMTRSKLPEVPVALDPHADALVAEQPYFLIDRAADWMLGSAKHFVGARRANLRAADFLAAVHVWATSFQIEPPNGVDGALVCCGEDYVAAWIHGTYPQPRPCPALDQLAALTTPVLRMAPRPLALPAGLWDDWSGLDLTRDTCINLQFPRPRTSRAAPREPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IT7</accession>
    <name>Q63IT7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111985.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1979"/>
    <dbReference type="EnsemblBacteria" id="CAH39457">
        <property type="protein sequence ID" value="CAH39457"/>
        <property type="gene ID" value="BPSS1979"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1979"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5483"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYDIDSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Unchr_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_cc" evidence="1">
        <location>
            <begin position="277"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="41584" checksum="564D9E22B7BE2BA3" modified="2004-10-25" version="1">MKRLAAVAMSVTQSISIPIHYPAATAALLLLLLTGCGGGGDQSKVNAAASPANNLVVPAPGTASPGTTPPAPGAPAPAETASVLPFFGVNGHYVDGGVYASVPLATQASHLAGLGMNVYRQDVYIPDHVDTLASTVIPGLGSGITVLPMIQAHPWADPSLNGQPPTEASAYAYAYKLAAYAAKKLAGIPMVEFGNEYDIDSHNAPIQGDGINVSDYDNSTFPIWRGALRGSLDGWRSVDTNRTTKLIANATSGALHFGFLDGLMTGTQPDGTTGHPKITPDVIQWHWYSNGGDFENALGKTGRYNVLARLKDRYNLPIVVTEIGVNTDNSDTQIAAYIAKTIPELVAAKAAYNVIGFNWYELYDDRSGAYGLLTNSAQEKPRYGLMRAAIAGAVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IV7</accession>
    <name>Q63IV7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cdd</name>
        <name evidence="13" type="ordered locus">BPSS1959</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187960.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111965.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63IV7"/>
    <dbReference type="STRING" id="272560.BPSS1959"/>
    <dbReference type="EnsemblBacteria" id="CAH39437">
        <property type="protein sequence ID" value="CAH39437"/>
        <property type="gene ID" value="BPSS1959"/>
    </dbReference>
    <dbReference type="GeneID" id="56598472"/>
    <dbReference type="KEGG" id="bps:BPSS1959"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5452"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="EvolutionaryTrace" id="Q63IV7"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH39437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="13630" checksum="742FCEBADE742691" modified="2004-10-25" version="1">MTHHALIEAAKAAREKAYAPYSNFKVGAALVTNDGKVFHGCNVENASYGLCNCAERTALFSALAAGYRPGEFAAIAVVGETHGPIAPCGACRQVMIELGKPTLEVVLTNMQGDVRVTSAGDLLPDAFYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX2</accession>
    <name>Q63IX2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adhA</name>
        <name evidence="4" type="ordered locus">BPSS1944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205709.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111950.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1944"/>
    <dbReference type="EnsemblBacteria" id="CAH39422">
        <property type="protein sequence ID" value="CAH39422"/>
        <property type="gene ID" value="BPSS1944"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1944"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5433"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GLKMTDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="36087" checksum="1D84B1A78F72309C" modified="2004-10-25" version="1">MAQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGFVAAVGEGVRHVKEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSVYGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKGIRVTDTRPGQWIAISGIGGLGHVAVQYAKAMGLHVVAVDVAPQKLELARKLGAAFVVDASKDDPAAVIQKEIGGVHGVLVTAVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLDFAAEGLVRAHIHRDKLEHINGVFSALREGKVDGRIVLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IY3</accession>
    <name>Q63IY3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111939.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1933"/>
    <dbReference type="EnsemblBacteria" id="CAH39411">
        <property type="protein sequence ID" value="CAH39411"/>
        <property type="gene ID" value="BPSS1933"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1933"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5419"/>
    <dbReference type="OMA" id="MHRDRKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="9014" checksum="94607FF6E3EDF9D4" modified="2004-10-25" version="1">MTHPDRKAIASTVAVFASQIGLIAAVRGLFVADGSAPYFMLFAIVAGVLGFVDLYYRPIFAPAFARQRVAFVHRRRGAARDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IY7</accession>
    <name>Q63IY7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544562.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111935.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1929"/>
    <dbReference type="EnsemblBacteria" id="CAH39407">
        <property type="protein sequence ID" value="CAH39407"/>
        <property type="gene ID" value="BPSS1929"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1929"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5415"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HQARIAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="494" mass="51637" checksum="0E6B660F1F3CD0B0" modified="2004-10-25" version="1">MCTSHPASRPRGGRPRLAAIALGCAAFVAGCAVGPDFIAPARPAVDAYVPDGAARTRFAASDATQTLAPDAPFPDAWWRLFGSREIDAAVDDAFAGSPTLARARATLARSEHALIAGAGVFYPQADAQAGASRQRYVPLRTGANLPASLFNLFTLSTTVSYALDLWGGERRHVEGLAAQADAQRHALAAARLTLAANVVNTMIARAAYADEIALTRELIALTDEQIRLTRAQVSAGTSAYTAVLALQAARASLDASLPALEQKTGEADDLLATLAGRYPAEHVPPQVSLAAIALPARLPRTVPSELVRRRPDILQAEAVLHAASANIGVASAALFPSVTLSASGGFDATRASALFGPAGRAWSVGASITAPLFHGGALWYQRKAAVDAFDESNAAYRQTVLSAFAQVADTLRALDHDATALDAQARAMSAARDARRLATVQYEAGTAGYLQVLLADQQYRQARLAWVQASAQRLQDTVALYAALGGGWGGARQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JK9</accession>
    <name>LEUC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="1">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM isomerase</fullName>
            <shortName evidence="1">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuC</name>
        <name type="ordered locus">BPSS1707</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528981.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111713.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JK9"/>
    <dbReference type="SMR" id="Q63JK9"/>
    <dbReference type="STRING" id="272560.BPSS1707"/>
    <dbReference type="EnsemblBacteria" id="CAH39181">
        <property type="protein sequence ID" value="CAH39181"/>
        <property type="gene ID" value="BPSS1707"/>
    </dbReference>
    <dbReference type="GeneID" id="56529882"/>
    <dbReference type="KEGG" id="bps:BPSS1707"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5120"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000076733" description="3-isopropylmalate dehydratase large subunit">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <sequence length="469" mass="50803" checksum="3D13BF73B202E410" modified="2004-10-25" version="1">MAQTLYDKLWNSHVVHTEEDGTALLYIDRQLLHEVTSPQAFEGLKLAQRPVWRISANLAVSDHNVPTTDRSHGIADPVSKLQVDTLDANCDAYGITQFKMNDVRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLLQKKSKNMLVKVEGQLPRGCTAKDIVLAIIGRIGTAGGTGYAIEFGGSTIRALTMEGRMTVCNMAIEAGARAGMVAVDDTTVEYLKGRPFVPTGAEWDQAVEYWKTFRSDEGAQFDRVVELDAAQIVPQVTWGTSPEMVTSIDGRVPDPEREKDPVKRDAMERALAYMALAPNTPIEAIKVDKIFIGSCTNARIEDIRAAAYVVKKLNRRVAPNVRLAMVVPGSGLVKAQAEREGLDKVFTEAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAIEGHFVDIRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP6</accession>
    <name>Q63JP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BPSS1671</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205661.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111676.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1671"/>
    <dbReference type="EnsemblBacteria" id="CAH39144">
        <property type="protein sequence ID" value="CAH39144"/>
        <property type="gene ID" value="BPSS1671"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1671"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5072"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWFFAEP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="79"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="388"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="420"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH39144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="636" mass="67423" checksum="12E14847961C080E" modified="2004-10-25" version="1">MSDITHAVGGAPPTSGLPAARADAPRFRIVPARHRARTAGTVLAAVLIALVLNSVLGNPQWGWPVFAEWFLSEPVLSGLARTLLLTALGALFGFALGVPLALARVSRSPLLAACAWAFIWLFRSIPLIVLLLILNNLGYLYDHVRLGVPFTGITFAEVATTDLISPFCAAVLGLTLNHAAFAAEGIRGGILSVDQGQLEAAAALGLPRARQATRIVLPQAMRAFLPVAFNDLIALAKGSSMVYVLAMPELFYTVQVIYRRNLEVIPLLMVATVWYLIILTVLSIVQAQVERRYARGAVREPERSPAAALVGRLAGALPRRRVGAAGRSDATGDARPASKAAGAPSAADAPGAAAPGASASFAASRAPGRARSPGAARAPASGRRGGEIAVQRVSKRFGAHKVLDDVSFVAPAGSVTVILGQSGSGKSTLLRTINHLERVDGGFIDIDGELIGYRREGDTLYELKEKDVLRRRADVGMVFQNFNLFAHLTVLENIVEAPVASGRATRAEAERDARELLARVGLAAKAHAYPRQLSGGQQQRVAIARALALKPKVLLFDEPTSALDPELVNEVLDVIKELARSGTTLVIVTHEIGFAREVADTVLFMEHGRIVEAGPPAQVLGAPAHPRTRAFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ0</accession>
    <name>Q63JQ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Formate dehydrogenase-O, iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fdoH</name>
        <name evidence="14" type="ordered locus">BPSS1666</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528944.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111672.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1666"/>
    <dbReference type="EnsemblBacteria" id="CAH39140">
        <property type="protein sequence ID" value="CAH39140"/>
        <property type="gene ID" value="BPSS1666"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1666"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5065"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KACQSAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10558">
        <property type="entry name" value="FDH-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006470">
        <property type="entry name" value="Formate_DH_bsu_Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038384">
        <property type="entry name" value="Formate_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015246">
        <property type="entry name" value="Formate_DH_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09163">
        <property type="entry name" value="Form-deh_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01582">
        <property type="entry name" value="FDH-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH39140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="33011" checksum="90A574E4CD064E33" modified="2004-10-25" version="1">MALQSLDIKRVSATTTPPPSAREPVTGSVAKLIDVSKCIGCKACQTACMEWNDLRDEVGTNVGVYDNPADLTEHSWTVMRFAEYENPAGDLEWLIRKDGCMHCEDPGCLKACPSPGAIVQYNNGIVDFHEEHCIGCGYCVTGCPFNIPRISKQDNRAYKCTLCSDRVAVGQEPACVKTCPTGAIVFGTKEDMKQHAAERVADLKGRGFENAGLYDPQGVGGTHVMYVLHHADKPSLYHGLPDNPSISPMVKLWKGLAKPLAVAGIALSALVGFFHYTRVGPNDVTDDEEAAARDEARRIQEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JU7</accession>
    <name>Q63JU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188009.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111625.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1617"/>
    <dbReference type="EnsemblBacteria" id="CAH39092">
        <property type="protein sequence ID" value="CAH39092"/>
        <property type="gene ID" value="BPSS1617"/>
    </dbReference>
    <dbReference type="GeneID" id="56597969"/>
    <dbReference type="KEGG" id="bps:BPSS1617"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5003"/>
    <dbReference type="eggNOG" id="COG4790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMQMVSP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005773">
        <property type="entry name" value="YopR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01102">
        <property type="entry name" value="yscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="216" mass="23710" checksum="ABBB809452DE8B4F" modified="2004-10-25" version="1">MVQFNDITGLLIAVLVMSMVPFIAMVVTSYAKIVVVLGLLRNALGVQQVPPNMVLNGIAILVSLYIMAPIGFAAQQQLQGQALSPQPTQAMLQAFGAAKEPFRRFLAAHSREREKRFFLRSASVIWPQAAAAQLREDDLIVLAPAFTLAQMTDAFRIGFILYIAFIIVDLVIANVLMSMGMNQVQPTNVAIPFKLMLFVVMDGWSTLVHGLVLTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K81</accession>
    <name>Q63K81_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0261 protein BPSS1484</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0261 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546897.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111491.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1484"/>
    <dbReference type="EnsemblBacteria" id="CAH38957">
        <property type="protein sequence ID" value="CAH38957"/>
        <property type="gene ID" value="BPSS1484"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1484"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4826"/>
    <dbReference type="eggNOG" id="COG5441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SDISMMY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00677">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="2">
        <location>
            <begin position="7"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="405" mass="42714" checksum="DEEB7CAB2B08E157" modified="2004-10-25" version="1">MVPHRTRIYVAATVDTKGAEAHFVKDRIADAGLAAVVVDLSTRVPGLAADIGADAVAAHHPDGAAAVFCGDRGRAIAAMAVAFEHYIKSRDDVAALIGIGGSGGTALVTPAMQALPIGMPKLMISTMASGDVSAYIGSSDIAMLYSVADIAGLNRISRQVLANGAHMIAGAVRDMQPPHADLKPALGLTMFGVTTPCIQAVTSRLDARFDCIVFHATGKGGPAMEKLADSGLLDGVLDLTTTEVCDLLMGGVLACGADRFDLIARSRVPYVGSCGALDMVNFGHIDTVPPRYAQRLLYKHNPQVTLMRTTPDENRRIGEWIGAKLNACDGPVRFLIPEGGVSALDAPGQAFWNPQADEALFDALEATVVQTERRRLVRVPAHINDARFADAAVEHFLSLHAAHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KD5</accession>
    <name>Q63KD5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycine-betaine binding ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200833.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111437.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1425"/>
    <dbReference type="EnsemblBacteria" id="CAH38900">
        <property type="protein sequence ID" value="CAH38900"/>
        <property type="gene ID" value="BPSS1425"/>
    </dbReference>
    <dbReference type="GeneID" id="56530155"/>
    <dbReference type="KEGG" id="bps:BPSS1425"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4750"/>
    <dbReference type="eggNOG" id="COG4176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDVFRHI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017784">
        <property type="entry name" value="ABC_transptr_choline_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03416">
        <property type="entry name" value="ABC_choXWV_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="88"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="32307" checksum="52A4082730B58368" modified="2004-10-25" version="1">MSELIPLGSWVDQSVHYLLDHDAKTFDAIGRAIEGLAALVEHGLQAVPMWLMMACFIGVGLWRVGWRFAFFTAASLFLIFATGFWDQTVVTLGLTLSSTIVSLVLGIPLGIWAAKSKWVAAIVRPILDLMQTMPAFVYLIPAAMLFGLGRVPGILSTVIFAMPPAVRLTSLGIRHVNREIVEAGQAFGCTPWQLLYKVQFPNALPSIMQGVNQTIMMALSMVIIASMVGAGGLGNDVLASIQRLDIGLGFESGLSVVLLAIILDRITESFGRAPGTARAPLFSGLRQLFGPRSRSPVVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS9</accession>
    <name>Q63KS9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184588.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111292.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1284"/>
    <dbReference type="EnsemblBacteria" id="CAH38753">
        <property type="protein sequence ID" value="CAH38753"/>
        <property type="gene ID" value="BPSS1284"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1284"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4563"/>
    <dbReference type="eggNOG" id="ENOG5030XDQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FNAFSHC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="38093" checksum="4A03175074770119" modified="2004-10-25" version="1">MTLMRLFLFNAFSYCFLLRRVVKRIALGRSPARGLGMMRWCAGVCLRLFPSIRGSIEMSVRHMLSAHLNDDPVRIRGVADGIVRELFEAEVAGLMLRSHSIASMKTLIDRMECEGEGVLRAALARGGPLMLAGLHFGNLMLYVSKLRLMIPDDRKMMIVMHKDAPGAFFDDAQRLVQEYGAGKIELIDIEQRVHLRRLVAGLRKEAPVFLLFSDLHGRFGKTNACRLGGRWVRLAGGGVKLAVEHDIPMLVSYATGVPFRDACKVHFVELDARPAPRMLGVADDASRVAAAHQRIADKLEEALVKQPEQWHFWEHFTPYLMPSPLLEQNARAAAQTLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KW5</accession>
    <name>Q63KW5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="9">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
            <shortName evidence="9">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folE</name>
        <name evidence="11" type="ordered locus">BPSS1248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="9"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528547.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111256.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1248"/>
    <dbReference type="EnsemblBacteria" id="CAH38715">
        <property type="protein sequence ID" value="CAH38715"/>
        <property type="gene ID" value="BPSS1248"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1248"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4505"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRPQVQE"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="10">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="210" mass="23588" checksum="E6E864332DB252F8" modified="2004-10-25" version="1">MHQTGNERACGAHDQPHAEIRRTGRFDPIAFEAAVRALLEASGIEIDSAHTGRTAQRVRELWQRRLLDGYEVDPAQALGAGFDDPREDMVIVRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRYTYQEWITHRIATALVTHGQARGAACLIEAEQLCLLMGENRRGDERVITQCYAGEFERDVQARNEFLRGIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L03</accession>
    <name>Q63L03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532395.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111218.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1210"/>
    <dbReference type="EnsemblBacteria" id="CAH38677">
        <property type="protein sequence ID" value="CAH38677"/>
        <property type="gene ID" value="BPSS1210"/>
    </dbReference>
    <dbReference type="GeneID" id="56530378"/>
    <dbReference type="KEGG" id="bps:BPSS1210"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4447"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYLCFGK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9056" checksum="1113943DA846D5A6" modified="2004-10-25" version="1">MRGVIRIGDSTSHGGRVETGREGSTVMGRAVACVGDRCTCPMNGHEHCVIVEGDEDVRIEGRAVAFDGHRTSCGATLVSSIPTSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L43</accession>
    <name>Q63L43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
            <ecNumber evidence="3">1.14.11.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.11.17" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551692.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111178.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1165"/>
    <dbReference type="EnsemblBacteria" id="CAH38633">
        <property type="protein sequence ID" value="CAH38633"/>
        <property type="gene ID" value="BPSS1165"/>
    </dbReference>
    <dbReference type="GeneID" id="56530421"/>
    <dbReference type="KEGG" id="bps:BPSS1165"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4396"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFADVWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000908">
        <property type="term" value="F:taurine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="4"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="31846" checksum="657AB1E9CF2BBBCE" modified="2004-10-25" version="1">MISRKLSPALGAEIRGIDFSEPLSSQARDDVIGLLSEHQLLVFPGQRLSCEQQIAACGAFGELEPHPMTTNTSSFPEMTIVSNVTSDGKPVGYPTPPFELWHSDLCYLEHPAKMTFFYAESVPDAHGDTWFANMFRAYETLPDELKAAIDGKHAVFSLDSSLVKRCRKIGFDLNIAEDDFKPTVSHPAVRTHPHTRQRSIFVNWAHTDRIEGYSPEESDEILDRIFAHCRNEDFIYRHRYANEDLVIWDNASLIHTNSPNPPVGNRIMRRVMVSGPKPFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L68</accession>
    <name>Q63L68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111153.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1140"/>
    <dbReference type="EnsemblBacteria" id="CAH38608">
        <property type="protein sequence ID" value="CAH38608"/>
        <property type="gene ID" value="BPSS1140"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1140"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5299"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAWSDVG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="176"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="320" mass="34464" checksum="4CF80FF376820C93" modified="2004-10-25" version="1">MMESTMSTDTPNSAPLSLPQRVLVAVDASKASQRAIDYLKYVVPAGAAVRFVSVVDTPRAYMLPHTFAPSEFAAAHTELVNDASNALGGATLTFGRVDVTVETAIVDLAKKGGDVVDALLDETRDWHADLLVVGSRQYQGLLRWVEGSVSEPLLARTDCAILFVPPGVESATHAPKRVLFATDGSPIAARALRYGAQFATPDTHLRAIYVIDRAVRLTDFVPIHMLEDAFVEESERALAVARQLLDEVPGQSSTAALSTDLTSDDVAHTIVREAERWPADLLVMGTHGRRGVSRWLLGSIAQRVARLTPIPLLLVHGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L71</accession>
    <name>Q63L71_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533059.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111150.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1137"/>
    <dbReference type="EnsemblBacteria" id="CAH38605">
        <property type="protein sequence ID" value="CAH38605"/>
        <property type="gene ID" value="BPSS1137"/>
    </dbReference>
    <dbReference type="GeneID" id="56530449"/>
    <dbReference type="KEGG" id="bps:BPSS1137"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4358"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHMFRNS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="30317" checksum="D84D72954DED70DF" modified="2004-10-25" version="1">MQNDFSLVVAPIFACSLIGLLWVKLRLPMNAACLSALVSNIGIPCLLLSSLDQPNLTARVLVHTFAAGAVALACFAALGALFLRALKLPLRQYLPSLMLPNTSNLGLPVALFAFGEQGLLYAVAFSALVQIGHFTIGVWLLSGRASWKSIAASPTIWAVAAALFMTVNGLHPSAPLAATAKQLGNMAPPLMLLMLGASLANIRLAGLHRVALLALVRVAGGLGVGLALACLLGLPSVAAGAFVVQCTMPVAVLSHLIAQQHDGPTEDIAGMILISTGLSLAGLPLMLASAKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LF2</accession>
    <name>Q63LF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative bacteriophage gp30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205520.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111069.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1058"/>
    <dbReference type="EnsemblBacteria" id="CAH38524">
        <property type="protein sequence ID" value="CAH38524"/>
        <property type="gene ID" value="BPSS1058"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1058"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4255"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVEMKFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="5">
        <location>
            <begin position="81"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="26545" checksum="9A38308006F37AEE" modified="2004-10-25" version="1">MSDYGTSSAVGGMSTGEGQTTRVGLSRGQLSPQDHAVLCDAICRCSRVGVATTDGKILRQACVSQRLKAKNLVAKGLTGAPTQYLPEVTYDMRQSPPAPVMSSADPLMPHSWLPAWIQKYFPGGMDAYKQAKKTYFRRPDVVIVNDPSQPPVQSNIKQIVEMKFPPDDFSKGQREAYLDIAGDDRKLAAIGPEDCRCGEADRQSQPSTSTQKQPNLEDMFGDKLPSSGGIMPLMPPIPPVPLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LY3</accession>
    <name>Q63LY3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528149.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110888.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0879"/>
    <dbReference type="EnsemblBacteria" id="CAH38341">
        <property type="protein sequence ID" value="CAH38341"/>
        <property type="gene ID" value="BPSS0879"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0879"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7171"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVYQHAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266426" evidence="7">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="8"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="374" mass="39179" checksum="B90CC5B6132B85DA" modified="2004-10-25" version="1">MNKTLIVAAVAASFATVAHAQSSVTLYGVLDAGITYQSNVATPSGSGKSLWSVGAGVDQSRFGLRGSEDLGGGLKAIFTLESGFNIGNGRFNNGGGMFNRQAFVGLSSNYGTVTLGRQYDATQDYLSPLSATGTWGGTYFAHRLNNDRLNTNGDVAVNNTVKFTSANYAGLQFGGTYSFSNNSQFANNRAYSAGASYQFQGLKVGAAYSQANNAGANTTGATDPLTGFNIGGTNAASIQGRSRVYGAGASYAYGPLQGGLLWTQSRLDNLANGAPTTRADNYEANVKYNLTPALGLGVAYTYTNAKANGESTHWNQVGVQADYALSKRTDVYAQAVYQRSSKNANASIYNGDLSTPFSTSINQTAATVGLRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LZ5</accession>
    <name>Q63LZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GerE family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110876.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0867"/>
    <dbReference type="EnsemblBacteria" id="CAH38329">
        <property type="protein sequence ID" value="CAH38329"/>
        <property type="gene ID" value="BPSS0867"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0867"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7157"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CLNTIAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="235" mass="25718" checksum="5994BE1880EC4959" modified="2004-10-25" version="1">MTYDPALSDADAAPSYARALQACVGSLQALARPTATVFYRIDASGEPVDFELFGMTAAMHRAYVSRYRPLDPLHPSRCASQPGAVVTLASQLPDERRDTSSYWTGFLRRHGVVDVVEVLLRDGGAVLAAFSLLRLACDGRYSAPEIAALRAVQPVVEAALLPPLRAVRGIRRIACDVRLTHREEQIARLVRDGRSNKAIARDLALGQPTVKTHLLRMFRKLGVSNRTELVGALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M41</accession>
    <name>Q63M41_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200916.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110830.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0819"/>
    <dbReference type="EnsemblBacteria" id="CAH38281">
        <property type="protein sequence ID" value="CAH38281"/>
        <property type="gene ID" value="BPSS0819"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0819"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7090"/>
    <dbReference type="eggNOG" id="COG3703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SNMNPAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="156" mass="17361" checksum="63E79056C09547C9" modified="2004-10-25" version="1">MSQVCYFAYGSNMSAARLSERLSRFGEALIERWPGIVDGYRLTFNKVSSRQDWVGFANIEAAADCRVEGTLNAMSARALDALDSIELVPLHYRRAGVLVRDGATGRLTLAVTYVANPAMVRPNLRPTRDYLDHLLAAADVLPRAYLDHVRAVECWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MG7</accession>
    <name>Q63MG7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523777.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110704.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0690"/>
    <dbReference type="EnsemblBacteria" id="CAH38150">
        <property type="protein sequence ID" value="CAH38150"/>
        <property type="gene ID" value="BPSS0690"/>
    </dbReference>
    <dbReference type="GeneID" id="56530860"/>
    <dbReference type="KEGG" id="bps:BPSS0690"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6904"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWVFSMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="34"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="395" mass="42662" checksum="B2BC495CB77068BD" modified="2004-10-25" version="1">MLIWKTALSLTWKAGLVSPASAPAAAAHVDRVVLTGATGFIGGAVLVSLVNAGLLDRVVCIVRACDRAHALARLRAAALRSGLAPYWAERLSEANVIAGELGGALADADAAHIALASHVIHCAGVASLADARIVNETNVGATLRFARRFAGSRRLQRFVHVGAAFACGLRARGTIREDDTPARGREIDFAPYTRGKRDAEAQLRALGLPLVVVRPSCVVGHTLLGTQPSASTFWMFRIVHAARRFTARPMARIDVIAVDDCARALMLLALKPSLAHDTYHVSAGDEAPTVTQIVRAMDEAVGLDDEPRYALCSPAEFPSIARDVLGRRDAPRERVIRRALQSYAAFAELDHVFDNARVRREIDFEPLPFVDYVNECMRTSRGIDVLAQMPRTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MP3</accession>
    <name>Q63MP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530106.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110628.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0607"/>
    <dbReference type="EnsemblBacteria" id="CAH38064">
        <property type="protein sequence ID" value="CAH38064"/>
        <property type="gene ID" value="BPSS0607"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0607"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6789"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYTEETF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07146">
        <property type="entry name" value="ALDH_PhpJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017656">
        <property type="entry name" value="Put_phosphonoacetaldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03250">
        <property type="entry name" value="PhnAcAld_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="25"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="490" mass="53500" checksum="4EA521E53C8643B8" modified="2004-10-25" version="1">MLNHRSAAFARVARALDARGKTSSGATLVVSHPYNRETVAELPLDSGDDARRKLQRAARFRSALSRHERIAVFDKAIALLAAEKRDASILITLESGLCRKDTMYEVDRVINVLHAAIAELNRDDGQTFSCDNATSDERRKIFTVREPLRGVIVAITPFNHPMNQVAHKICPAIASNNRIVLKPSEKTPLSALYLLDLFREAGLPEPMFDVVIGEPNALGAALVCDEHVELVAFTGSVAVGKRIAQMAGYRRTVLELGGNDPLIVMEDADLERAAQLAAKGSYKNSGQRCTAVKRILVERTVARPFTELLVEHSRRWQTGDPMDERVDIGTLIDDAAAIECARRVDEARDAGARVLLGHQRDGAAYAPTVLERVGPALRLVQQETFGPVSPVITFCGLDEAVAIANSTRYGLSSGVCTNRLDYITHLIAHLDVGTVNVWEVPGFRLESTPFGGVKDSGLGSKEGMQEAIKNFTNLKTYSLPWDTLAHPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU1</accession>
    <name>Q63NU1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aconitate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">acnA</name>
        <name evidence="10" type="ordered locus">BPSS0208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556539.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110228.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0208"/>
    <dbReference type="EnsemblBacteria" id="CAH37653">
        <property type="protein sequence ID" value="CAH37653"/>
        <property type="gene ID" value="BPSS0208"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0208"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6278"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRASYMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012708">
        <property type="entry name" value="2Me_IsoCit_deHydtase_FeS-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670:SF43">
        <property type="entry name" value="PTHR11670:SF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02333">
        <property type="entry name" value="2met_isocit_dHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="9">
        <location>
            <begin position="657"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="864" mass="93904" checksum="6C286C89554F6CB1" modified="2004-10-25" version="1">MNTANRKPLPGTSLDYFDARAAVDAIRPGAYDALPYTSRVLAENLVRRCDPAILADSLTQLVERKRERDFPWFPARVVCHDILGQTALVDLAGLRDAIAERGGDPAKVNPVVPVQLIVDHSLAVECGGFDPGAFAKNRAIEDRRNEDRFHFIEWTKKAFENVDVIPPGNGIMHQINLEKMSPVIQAQDGVAYPDTCVGTDSHTPHVDALGVIAIGVGGLEAENVMLGRASWMRLPDIVGVELTGKRQPGITATDVVLALTEFLRREKVVGAYLEFRGEGAKSLTLGDRATISNMAPEYGATAAMFFIDEQTIDYLRLTGRSDEQVKLVETYAKAAGLWADSLAHAQYERTLTFDLSSVVRNMAGPSNPHKRLPTSDLAARGIAGKWEEKPGEMPDGAVIIAAITSCTNTSNPRNVIAAALLARNANARGLARKPWVKSSLAPGSKAVELYLKAANLLPELEKLGFGIVAFACTTCNGMSGALDPKIQREIVDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDALGHDKDGKPVTLKDIWPTDEEIDAIVASSVKPEQFRTVYEPMFARAADAGERAAPLYDWRPRSTYIRRPPYWEGALAGERTLKGMRALAVLGDNITTDHLSPSNAILPTSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPTLVNEMAIVDGEVKKGSLARVEPDGKVMRMWEAIETYMSRKQPLVVIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLIGMGVLPLEFKPGTNRATLAIDGTETFDVIGERTPRADLTLVIHRSSGERVAVPVTCRLDTAEEVSIYDAGGVLQRFAQDFLESSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P20</accession>
    <name>Q63P20_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyk</name>
        <name evidence="15" type="ordered locus">BPSS0128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533798.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110149.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0128"/>
    <dbReference type="EnsemblBacteria" id="CAH37573">
        <property type="protein sequence ID" value="CAH37573"/>
        <property type="gene ID" value="BPSS0128"/>
    </dbReference>
    <dbReference type="GeneID" id="56531424"/>
    <dbReference type="KEGG" id="bps:BPSS0128"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6168"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="13"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="372"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH37573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="484" mass="51208" checksum="C9B1D4C25E697778" modified="2004-10-25" version="1">MRNESHTARERRRSTKIVATLGPSSSTETAIEALARAGADVFRLNFSHGTHADHALRHAAVRAIEARIGHPIGVLLDLQGPKLRVGQFASGRAQIAKGRPFVFDRDPAPGDARRVSLPHPEIFDAARPGHLLLVDDGKLRFRVDAVSSARIETTALLDGIVSDRKGVSVPDATLAIPALSAKDRDDLEFGLSLGVDWVALSFVQTAQDVRDARALIGARAAIVAKIEKPQAVANIAEIVDAADAVMVARGDLGVEMSLEDVPSVQKQIIRLARAAGKPVIVATQMLESMTLAPTPTRAEASDVAAAVYDGADAVMLSAESASGQYPVEAVDFMRKIISTTEADPIQPQLMKAIVTAHAPNATDAIGAAIEVVSDTLRLGVAVTYTASGATAIRLSRLRPSTAILSLTPRAEIARRLTLAWGVRSRVAAEATGIENIVEIAIEAAHAEGFATDECPIVVAAGVPFGHPGSTNLMRIVWPTEMTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P39</accession>
    <name>Q63P39_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536657.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110130.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0109"/>
    <dbReference type="EnsemblBacteria" id="CAH37554">
        <property type="protein sequence ID" value="CAH37554"/>
        <property type="gene ID" value="BPSS0109"/>
    </dbReference>
    <dbReference type="GeneID" id="56531443"/>
    <dbReference type="KEGG" id="bps:BPSS0109"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6138"/>
    <dbReference type="eggNOG" id="COG3539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFRIELV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266209" evidence="1">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="200"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="342" mass="36157" checksum="11751D4C7F81E680" modified="2004-10-25" version="1">MKKKFSRFLAALVLLAATVDALAAGCNMLTAENIAWLTEQGKIARAHSSFPISFSSGMVDVDPNLEIGGLIAEAKSIPSEELHFIWCSAPSGNVHFALNSSPLPSELGNSIYETGVPGVGFRITQVRQSGSIGAIPRDTPWIEEKPGQDSSLNFGAGTVFRIELIKTSEALPSESTISLGNLSRVYGDDNKTVVDFNAGSVKLRVLPICHVDQQEKNVDFGQFGPKDVSFDSGPTKDVKFDVQCSGPTPPVSITATLAATPDSHDQSLIANAGDAMNLAIRLRDASTQQVLRPNDPTSEIKVEPGGAMEHGFALEATVLRVGTAPPTAGTIDATSIITLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P41</accession>
    <name>Q63P41_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110128.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0105"/>
    <dbReference type="EnsemblBacteria" id="CAH37551">
        <property type="protein sequence ID" value="CAH37551"/>
        <property type="gene ID" value="BPSS0105"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0105"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4029"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SGYRYEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="3">
        <location>
            <begin position="436"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="899" mass="96381" checksum="F987EDF9305E3240" modified="2004-10-25" version="1">MFLGKWKREDCMPNHFSNGRTNQSRTVVIRSGAMPRLLGQPALEFLSLRGEEHLGKLYTYELLLRTPDDFHVPLATSANLDLKAMIGTEMTVCIQLDGIGTGAQGGVGAGAREISGLVVKAGFLRCEGRYNVYRIELRPWLWLATLTSDYKIFQDKSVVEIIDTVLHDYPYPVEKRLDIDKYSVAGESARNEPRAFQVQYGETDFDFVQRLMEEWGIYWFFEHSDNKHRLVLCDHIGGHRKAPSEAYHEIAHHPEGGKIDIEYINYFSTDEALRPGRVVIDDFDFTRPLASLVTSNHQPRETNWGEGELFEWPGDYTDSKHGDLISRVRMEERRATGSRAYGRGNVRGLACGHTFVLSKHKHDGANREYLVIESALMLTEVADETGSGYRYECDNELVVQPSNEVFRMPRETPKPTTSGPQSAIVVGPPGHEVWTDEFGRVKIRFLWDRYARNDATDSCWVRVSQAWAGVNFGGIYIPRIGQEVIVGFMNGDPDRPLILGSLYNTITPPPWDLPGDATKSGFKSKSITGGRENYNGIRFEDKLGAEEFHMQAEKDMNRLTKNDESHTVGANFSIGVGLTHTRAVGAMFSSIVGGAASYAVGGAESTMIGGAYALNVGGAHAVAVGGASSVSVGGAYARNVGGAYALTVGGVLSIVCGASSITMTACGSIKLVGKNIRIIGSDEVVVQGAPLQLNPGDSDCGGGGGGGGGGGAIPPIPLPSFFLDITKPILPPPPPPPTEVPPDPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPMPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PA3</accession>
    <name>Q63PA3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-hydroxybenzoate hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pobA</name>
        <name evidence="2" type="ordered locus">BPSS0042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.13.2" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556451.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110066.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0042"/>
    <dbReference type="EnsemblBacteria" id="CAH37485">
        <property type="protein sequence ID" value="CAH37485"/>
        <property type="gene ID" value="BPSS0042"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0042"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6045"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVEPMQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="45189" checksum="7F699EB6BCCC0CBC" modified="2004-10-25" version="1">MRTQVAIIGAGPSGLLLSHLLRLQGVDSVVLETRSREYCENRIRAGVLEQGTVDTLNDAGLGARMRREGLVHCGIELLFDGRRHRIDFGELTPGRAITVYSQHEVVRDLIEAALEHGQPIHFDVRDVALHDVATERPSVTFMHADGRPDRIDCDYVAGCDGFHGVARQAIPAERRRTFERVYPYAWLGILADAAPSLDELVYAHHARGFALFSMRSPTVTRLYLQCRPDENLAEWPDARIWEELGTRFENDGGWTPTPGRITQKSVTPMRSFVSETMQHGRLFLAGDAAHIVPPTGAKGMNLAVADVRALSRALVARYRHGRGDLLDAYSSTCLERIWRAEHFSYSMTNMLHPCADDSPFVNRLKLAELRYVTRSRAAAQSLAENYVGLPFDETAGDAPSFGEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PN8</accession>
    <name>Q63PN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198227.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109931.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3335"/>
    <dbReference type="EnsemblBacteria" id="CAH37348">
        <property type="protein sequence ID" value="CAH37348"/>
        <property type="gene ID" value="BPSL3335"/>
    </dbReference>
    <dbReference type="GeneID" id="56593958"/>
    <dbReference type="KEGG" id="bps:BPSL3335"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1876"/>
    <dbReference type="eggNOG" id="COG4259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYWGDYQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014508">
        <property type="entry name" value="UCP020555_TPR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16068">
        <property type="entry name" value="DUF4810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266517" evidence="2">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="142" mass="15568" checksum="F0CED0AB5DE330C6" modified="2004-10-25" version="1">MKKTFKTGAWLPVAAAGVLLAGCAANQPKPLYQWDGYQPQVYEYFKGQKSPEDQIDALEKALQQIRAKGNRPPPGFEAHLGMLYASVGKEQQAEQSFQAEKASFPESSPFMDFLLKKKAAAPQAKPSAPAQPQTQTQTQAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PP8</accession>
    <name>Q63PP8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198212.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109921.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3325"/>
    <dbReference type="EnsemblBacteria" id="CAH37338">
        <property type="protein sequence ID" value="CAH37338"/>
        <property type="gene ID" value="BPSL3325"/>
    </dbReference>
    <dbReference type="GeneID" id="56593968"/>
    <dbReference type="KEGG" id="bps:BPSL3325"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1889"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEHNWDS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="73" mass="7597" checksum="2F10C59E796B0DEC" modified="2004-10-25" version="1">MNAFYEGLAEIFEIDASEVTPALALGEHNWDSLAIVSTIALADDCFGVLLNGQALGNCKTVADIDALVAAQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PR3</accession>
    <name>Q63PR3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Flagellar transcriptional regulator FlhC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">flhC</name>
        <name evidence="6" type="ordered locus">BPSL3310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the FlhC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198198.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109906.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3310"/>
    <dbReference type="EnsemblBacteria" id="CAH37323">
        <property type="protein sequence ID" value="CAH37323"/>
        <property type="gene ID" value="BPSL3310"/>
    </dbReference>
    <dbReference type="GeneID" id="56593985"/>
    <dbReference type="KEGG" id="bps:BPSL3310"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1906"/>
    <dbReference type="eggNOG" id="ENOG502Z927">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLQLSAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01891">
        <property type="entry name" value="FhlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007944">
        <property type="entry name" value="FlhC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05280">
        <property type="entry name" value="FlhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003159">
        <property type="entry name" value="FlhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4 5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="20450" checksum="EE250BA79FF57F0D" modified="2004-10-25" version="1">MASKSVVVEVKEITLAIELIELGARLQLLEAETNLSRDRLIKLYKELKGVSPPKGMLPFSTDWFMTWQPNIHSSLFYNIYRFMREHGGCDSIQSIVKAYRLYLEHVGLSDDEAVLSLTRAWTLVRFFDSGMLQMTPCTRCGGHFVAHAHDPHHGYVCGLCQPPSRAGKTRKAAAQGDQAAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QF8</accession>
    <name>Q63QF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549937.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109660.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37076">
        <property type="protein sequence ID" value="CAH37076"/>
        <property type="gene ID" value="BPSL3065"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3065"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2197"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WEGGVHL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015185">
        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011265">
        <property type="entry name" value="GABA_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01773">
        <property type="entry name" value="GABAperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="16"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="467" mass="49648" checksum="13973E523D92E922" modified="2004-10-25" version="1">MEGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGVGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVIWRISLFYLGSIFVVAALVPWNDALLPVHGSYQRAMELIGVPHAKGIIDVIVLVSVASCLNSALYTASRMIFSLSTRGDAPAFLRRTDASGTPRAAVLASTAFGFLTVIANYVMPEQVFGFLLATSGAIALLVYLVIAISQLRMRSTLDATGERLPLRMWCFPWLTWAVIVFICGVLVVMLLREDHRMEVGATAVLALAVVVASRMNRRARGGDEPTPAASRVSANLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QH7</accession>
    <name>Q63QH7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan lytic exotransglycosylase</fullName>
            <ecNumber evidence="2">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Murein hydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2019" name="Sci. Rep." volume="9" first="11060" last="11060">
            <title>The lytic transglycosylase, LtgG, controls cell morphology and virulence in Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Jenkins C.H."/>
                <person name="Wallis R."/>
                <person name="Allcock N."/>
                <person name="Barnes K.B."/>
                <person name="Richards M.I."/>
                <person name="Auty J.M."/>
                <person name="Galyov E.E."/>
                <person name="Harding S.V."/>
                <person name="Mukamolova G.V."/>
            </authorList>
            <dbReference type="PubMed" id="31363151"/>
            <dbReference type="DOI" id="10.1038/s41598-019-47483-z"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) OF 25-372</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109641.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="6QK4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.73 A"/>
        <property type="chains" value="B=25-372"/>
    </dbReference>
    <dbReference type="PDBsum" id="6QK4"/>
    <dbReference type="SMR" id="Q63QH7"/>
    <dbReference type="STRING" id="272560.BPSL3046"/>
    <dbReference type="EnsemblBacteria" id="CAH37057">
        <property type="protein sequence ID" value="CAH37057"/>
        <property type="gene ID" value="BPSL3046"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3046"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2221"/>
    <dbReference type="eggNOG" id="COG2821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DQNGHPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14485">
        <property type="entry name" value="mltA_like_LT_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026044">
        <property type="entry name" value="MltA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034654">
        <property type="entry name" value="MltA_3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005300">
        <property type="entry name" value="MltA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30124">
        <property type="entry name" value="PTHR30124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03562">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019422">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00925">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266685" description="Peptidoglycan lytic exotransglycosylase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="MltA" evidence="7">
        <location>
            <begin position="134"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6QK4"/>
        </source>
    </evidence>
    <sequence length="372" mass="39978" checksum="D4E7BC70757BF4B9" modified="2004-10-25" version="1">MGFSRRLAGWAAAVAAAALLAACVGSPVRQGARPAGAAIVPGQIAAARLTPVAWQQVPGWQDDSLIGATIALRQNCARLARQANWQRACAAAMRLDDLDVGSARTFFETYFTPFQFANNDGTLDGLVTGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGASMPARAQLMRSGALSGNELVWVDDPIEAFFLQVQGSGRVVLDDGTVMRVGYGGTNNQPYRSIGKWLLDHGELGAGQATMQGIKAWARANPSRVDALLDTNPRFVFFREMPSQEDVPHGGADGPVGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPMTNAPLNRLVFAQDVGTAIKGGVRADYFWGLGDDAGDQAGRMKQNGRMWLLFPNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM4</accession>
    <name>RPPH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA pyrophosphohydrolase</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Di)nucleoside polyphosphate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rppH</name>
        <name evidence="1" type="synonym">nudH</name>
        <name type="ordered locus">BPSL2999</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. RppH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194263.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109594.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QM4"/>
    <dbReference type="SMR" id="Q63QM4"/>
    <dbReference type="STRING" id="272560.BPSL2999"/>
    <dbReference type="EnsemblBacteria" id="CAH37010">
        <property type="protein sequence ID" value="CAH37010"/>
        <property type="gene ID" value="BPSL2999"/>
    </dbReference>
    <dbReference type="GeneID" id="56594253"/>
    <dbReference type="KEGG" id="bps:BPSL2999"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2271"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PCVGIML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03671">
        <property type="entry name" value="Ap4A_hydrolase_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00298">
        <property type="entry name" value="Nudix_RppH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022927">
        <property type="entry name" value="RppH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231902" description="RNA pyrophosphohydrolase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="216" mass="25263" checksum="BB9E37FD1C8BA662" modified="2004-10-25" version="1">MLDREGFRPNVGIILLNAHNEVFWGKRLREHSWQFPQGGIKYGETPMQAMYRELHEETGLLPEHVKIIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDAVIEFKRDVYQLALTELSRFLRRPAQRTDKSRGPRAPRYPRVANGHAASEAPAAIDTSAVCSEVEPGANALDETPPRVSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QQ9</accession>
    <name>Q63QQ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195081.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109559.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2965"/>
    <dbReference type="EnsemblBacteria" id="CAH36975">
        <property type="protein sequence ID" value="CAH36975"/>
        <property type="gene ID" value="BPSL2965"/>
    </dbReference>
    <dbReference type="GeneID" id="56594214"/>
    <dbReference type="KEGG" id="bps:BPSL2965"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2310"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FSSISYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="28401" checksum="5DABABBE3CBD1A75" modified="2004-10-25" version="1">MASHRESNGALDAQHERYARYPSLVGRAVLITGGATGIGASFVEHFARQGARVAFVDLDEKAGRALVARLADAAHEPVFVVCDLTDIGALRGAIDAIRVRIGPIAVLVNNAANDVRHAVADVTPESFDASIAVNLRHQFFAAQAVIDDMKRLGGGAIVNLGSIGWMLKNAGYPVYATAKAAVQGLTRALARELGPFGIRVNTLVPGWVMTDKQRRLWLDDAGRAAIKAGQCIDAELLPGDLARMALFLAADDSRLITAQDVVVDGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QS8</accession>
    <name>Q63QS8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aerobic C4-dicarboxylate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dctA</name>
        <name evidence="8" type="ordered locus">BPSL2946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194164.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109540.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2946"/>
    <dbReference type="EnsemblBacteria" id="CAH36956">
        <property type="protein sequence ID" value="CAH36956"/>
        <property type="gene ID" value="BPSL2946"/>
    </dbReference>
    <dbReference type="GeneID" id="56528251"/>
    <dbReference type="KEGG" id="bps:BPSL2946"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2334"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHGMNVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="440" mass="46680" checksum="6BA761BD0677D0FE" modified="2004-10-25" version="1">MSKFLNSLFGRVVIALLIGVALGAFFPHFAQSLRPLGDGFLKLIKMVIGPIVFCVVVSGMANAGDLKKVGRVGLKAVIYFEAMTTLALGIGLVLAYLTKPGVGMNVDLHTLDPASLADYAKNAQSLKDTAGYLLKIIPETAFDAFAKGDILQILVFSVLFGSALSLLGEKAKRVNTLIDEFAQVFFRVMGFIIKLAPLGVLGAIAFTTGKYGVASLKQLGLLVIVFYASCIAFVVIVLGAVMKLAGFSVFKLIRYLREELLIVLGTASSDAVLPQVMRKLEWMGVKDSTVGLVIPTGYSFNLDGFSIYLTLAVLFIAQATNTPLSVHDLIVVLLVSLVTSKGAHGIPGSAIVILAATLSAIPALPVLGLVLILPVDWFVGIARALTNLLGNCVATIVVAVWEHDIDRARAQRVLNEELRYVPAGDESPRGAISDGGAHAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QX8</accession>
    <name>PUR9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="1">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">IMP cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">purH</name>
        <name type="ordered locus">BPSL2896</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="1"/>
    <dbReference type="EC" id="3.5.4.10" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527723.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109490.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QX8"/>
    <dbReference type="SMR" id="Q63QX8"/>
    <dbReference type="STRING" id="272560.BPSL2896"/>
    <dbReference type="EnsemblBacteria" id="CAH36906">
        <property type="protein sequence ID" value="CAH36906"/>
        <property type="gene ID" value="BPSL2896"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2896"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2394"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000018861" description="Bifunctional purine biosynthesis protein PurH">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <sequence length="521" mass="55486" checksum="EF9346CAEF24EB3C" modified="2004-10-25" version="1">MIKQALISVSDKTGIVDFAKALSALGVKLLSTGGTAKLLADAGLPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRDLPEHMQALEAHGIPTIDLLVVNLYPFVQTIAKDDCTLADAIENIDIGGPTMLRSAAKNHRDVTVVVDPADYAVVLDEMKANGNTLGYKTNFRLATKVFAHTAQYDGAITNYLTSLGDDLQHGSRSAYPATLNLAFDKVQDLRYGENPHQSAAFYRDVATPAGALANYRQLQGKELSYNNIADSDAAWECVKTFDAPACVIIKHANPCGVAVGADAGEAYAKAFQTDPTSAFGGIIAFNREVDEAAAQAVAKQFVEVLIAPSFSDAAKQVFVAKQNVRLLEIALGEGHNAFDLKRVGGGLLVQSLDSKNVQPRELRVVTKRHPTPKEMDDLLFAWRVAKYVKSNAIVFCGNGMTLGVGAGQMSRVDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVAAGATCVIQPGGSVRDDEVIAAADEHNIAMVVTGVRHFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ3</accession>
    <name>Q63QZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533594.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109475.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2881"/>
    <dbReference type="EnsemblBacteria" id="CAH36891">
        <property type="protein sequence ID" value="CAH36891"/>
        <property type="gene ID" value="BPSL2881"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2881"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2413"/>
    <dbReference type="eggNOG" id="COG4389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYITRDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011385">
        <property type="entry name" value="Site-sp_rcmbase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10136">
        <property type="entry name" value="SpecificRecomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015380">
        <property type="entry name" value="Site-sp_rcmb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="705" mass="76322" checksum="B82ED8AD31B70587" modified="2004-10-25" version="1">MFESLTTLIKKWRASRSASHQLDALLATADANAPYAERAEWLIELAHWLHRDGAMTAAAPAQPESGERAFAAHARLRYVFHVLDRNPAWKTNVARLLRGVLRESDGISLLCDAGMPVHSGFFGALVERIDSSLIPPAPNRRELAALFTLMFPAPADAQWIDALPDDLLARLAELFAFDVTDKERHQPGSFSRDLLAALHNLTCQISSTGLSQTVRSRLSDEDARTPLEAQPFYRLTRAMLAVETAQAALDDGGDASKLLHEVNYLRVLLDECRVSIDDVFSHLYRNGVSVDIVFQVERMRMRILRAETLLNAWMARDDLRGLARLTAELVDANQNSQSVSHLVRSNFALFARKLVETNADTGEHYISRGRAEYLKMLRMAAGGGLVTVATVCIKFGITGAHLQSMFEGLLAGINYAASFMLMHFLHFTLATKQPAMTAPTIARELDGTGHDEGVKQFVSSVIALIRTQAAAICGNVLVVLPVCFAVQMFASGVLHANLISPDKAHATLKSFSLFGPTPIYAALTGVLLWASSLLAGWADNWFVLHRVGDALAYNRRLRITLGVAGAAKLAHFCRSNVAGVVGNVGLGLMLGLVPAIVSAFAFSFEVRHVTLSAGSIGVAIGVLGKETLRSAELWWAVAGVFSMAILNVAVSFALAFTMAVRSRSLRPTKVRALVAAIGRAVLARPASLVWPPRGAGGAAGESRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R33</accession>
    <name>Q63R33_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobalamin adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:53304"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201622.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109435.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2841"/>
    <dbReference type="EnsemblBacteria" id="CAH36851">
        <property type="protein sequence ID" value="CAH36851"/>
        <property type="gene ID" value="BPSL2841"/>
    </dbReference>
    <dbReference type="GeneID" id="56593744"/>
    <dbReference type="KEGG" id="bps:BPSL2841"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2460"/>
    <dbReference type="eggNOG" id="COG2096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="6">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="190" mass="20295" checksum="42D661F2FE968AFA" modified="2004-10-25" version="1">MGNRLSKIATRTGDDGTTGLGDGSRVRKDDARIAAIGDVDELNSQLGVLLAEPLPDDVRAALSSIQHDLFDLGGELCIPGHAAITDAHLARLDDWLAHYNAQLPPLEEFILPGGARGAALAHVCRTVCRRAERAIVALGVHAPLDAAPRRYVNRLSDLLFVLARVLNRAAGGADVLWDRTRAHGTPHGTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R58</accession>
    <name>MIAA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="1">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="1">IPP transferase</shortName>
            <shortName evidence="1">IPPT</shortName>
            <shortName evidence="1">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA</name>
        <name type="ordered locus">BPSL2815</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527674.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109410.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63R58"/>
    <dbReference type="SMR" id="Q63R58"/>
    <dbReference type="STRING" id="272560.BPSL2815"/>
    <dbReference type="EnsemblBacteria" id="CAH36825">
        <property type="protein sequence ID" value="CAH36825"/>
        <property type="gene ID" value="BPSL2815"/>
    </dbReference>
    <dbReference type="GeneID" id="56528382"/>
    <dbReference type="KEGG" id="bps:BPSL2815"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2490"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000163893" description="tRNA dimethylallyltransferase">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="166"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="251"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="324" mass="35096" checksum="098B3E125E15599B" modified="2004-10-25" version="1">MSERNAASARTVACLLGPTASGKTAAALALAARRPIEIVSVDSALVYRGMDIGTAKPTRDERAAVPHHLIDIVDPADAYSAAEFRADALRLVAQIAARGRTPLLAGGTMLYYRALTQGLNDLPAADPDVRATLDADAARDGWPALHARLAGIDPATAARLAPNDSQRIQRALEVYLLTGQPMSALLAAPPRDDDAAAGLRFVPVALEPSERAVLHARIAARFDAMLEAGFIDEVERLRRRDDLHLGLPSMRCVGYRQAWEYLDGCTDYRTMRDKGIFATRQLCKRQLTWLRAMPERIVVDCCAPDATVRAVDALERVLDGRAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R64</accession>
    <name>Q63R64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative capsule polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wcbA</name>
        <name evidence="1" type="ordered locus">BPSL2809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205226.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109404.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2809"/>
    <dbReference type="EnsemblBacteria" id="CAH36819">
        <property type="protein sequence ID" value="CAH36819"/>
        <property type="gene ID" value="BPSL2809"/>
    </dbReference>
    <dbReference type="GeneID" id="56528388"/>
    <dbReference type="KEGG" id="bps:BPSL2809"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3205"/>
    <dbReference type="eggNOG" id="COG3563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYIKIHP"/>
    <dbReference type="PHI-base" id="PHI:4469"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015774">
        <property type="term" value="P:polysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007833">
        <property type="entry name" value="Capsule_polysaccharide_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05159">
        <property type="entry name" value="Capsule_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="671" mass="74685" checksum="458C2D8012EA0B5C" modified="2004-10-25" version="1">MTRSTASRRNWSNTLLHPVRVLCRQRPKRSSDTDREYIWIDRKIGRMALSIAHSCGARTRAAWPGPIWAEVPAGTPLLSWFVVPVTHAGPDAFVQALDAALEQDCTAGTAAAVAELMKRVLASHAIRGRDGVSEFRAPPRLPGETRVLLIDERKYSQGIGAVATRNNRGAFERMIRAARAAHPDAEFWLARTRDRGSGVWLSASAADILPADIHRLGEHESLCAALEHVDHVYTVGASEGMQALLAGRRVHVFGAPYYAGWGLTDDAVQLPGRHARPTLAALFDVVFLRFARYLNPATHAPGRIDDLLDAIEWQNTVRRRFADLRQVAGIRFQWWKRPFATPYLTAGGGTLRWTRDASRLREGEHAALWGARGTNDLPPGTRVIRIEDGFLHSTGLGSDHVAPCSQVIDRSGLYFDPSRPSDLTTILNETDFDDAELVRANRLRREIARLGLTKYNLGRRKPAWSPPPGKRVVLVPGQVADDASIRLGTRGITTAEDLLREVRARRPDAFIVYKPHPDVLSGNRRGAIEVNAWADLIEQDADLISLIEVADEIHTLSSLSGFEALIRGKAVHTYGLPFYAGWGLTQDALAQPWRKRTLSLDMLTAGVLLRYPVYWDWSLRLFASPELVVRQLAIPAARPLTSIRGDRLRPVRKASRWIASCLRHLLWQCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF8</accession>
    <name>Q63RF8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109310.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36722">
        <property type="protein sequence ID" value="CAH36722"/>
        <property type="gene ID" value="BPSL2714"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2714"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3095"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTPILLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="26872" checksum="836F6D1F865541D8" modified="2004-10-25" version="1">MPHIDPLYSLSGLFVGFLVGLTGVGGGSLMTPILVLLFNVHPATAVGTDLLYAALTKATGTFVHGLKGTVEWRITGRLAAGSVPAAAITLWFLHAHGMHSQETSRMIQFVLGAALLLTSLSLLLRPQLAAFAAKRTRALPPNPTRTLAATVLTGAVLGVLVSLTSVGAGAIGVTVLLLLYPALSTTRIVGSDIAHAVPLTLVAGVGHWMLGSVDWAMLVSLLIGSVPGIVVGSHLSARAPEGLLRRVLAATLVAVGAKLVLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RH9</accession>
    <name>Y2693_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0301 protein BPSL2693</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL2693</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185441.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109289.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RH9"/>
    <dbReference type="SMR" id="Q63RH9"/>
    <dbReference type="STRING" id="272560.BPSL2693"/>
    <dbReference type="EnsemblBacteria" id="CAH36701">
        <property type="protein sequence ID" value="CAH36701"/>
        <property type="gene ID" value="BPSL2693"/>
    </dbReference>
    <dbReference type="GeneID" id="56594987"/>
    <dbReference type="KEGG" id="bps:BPSL2693"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2649"/>
    <dbReference type="eggNOG" id="COG1678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYWGGDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258808" description="UPF0301 protein BPSL2693">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <sequence length="192" mass="20646" checksum="F50D4FD6F4264A70" modified="2004-10-25" version="1">MSKSSDRINLTNQFLIAMPNMADPTFSGTVVYLCDHSERGALGLVINRPTDIDLESLFNRIDLKLEIEPLLHIPVYFGGPVQTERGFVLHEPVEGSAYNSSMTVEGGLEMTTSKDVLEAVATGTGPKRFLLTLGHAGWGAGQLEEEISKNGWLTVAADPRIVFDTPAEERFEAALGLLGVSSSMLSGEAGHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RI0</accession>
    <name>YQGF_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL2692</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YqgF nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186163.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109288.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RI0"/>
    <dbReference type="SMR" id="Q63RI0"/>
    <dbReference type="STRING" id="272560.BPSL2692"/>
    <dbReference type="EnsemblBacteria" id="CAH36700">
        <property type="protein sequence ID" value="CAH36700"/>
        <property type="gene ID" value="BPSL2692"/>
    </dbReference>
    <dbReference type="GeneID" id="56594988"/>
    <dbReference type="KEGG" id="bps:BPSL2692"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2650"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PNWDDIE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000172038" description="Putative pre-16S rRNA nuclease">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <sequence length="146" mass="16240" checksum="58A3B0B294C994A7" modified="2004-10-25" version="1">MSAALSRDATLLAFDYGEKRIGVAVGNLLTRTARALVIVRNLNREHRFKAVGELIAEWKPDALVVGLPLHPDGAPHEMTQRAMRFGNQLNGRFNLPVSWVDERYSSVEARAGLRARGDAADRVDAEAARVILQQYLDGLPDHHEFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RL0</accession>
    <name>UREG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureG</name>
        <name type="ordered locus">BPSL2662</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185810.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109258.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RL0"/>
    <dbReference type="SMR" id="Q63RL0"/>
    <dbReference type="STRING" id="272560.BPSL2662"/>
    <dbReference type="EnsemblBacteria" id="CAH36670">
        <property type="protein sequence ID" value="CAH36670"/>
        <property type="gene ID" value="BPSL2662"/>
    </dbReference>
    <dbReference type="GeneID" id="56594810"/>
    <dbReference type="KEGG" id="bps:BPSL2662"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2682"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDLTIYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0996">Nickel insertion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000347375" description="Urease accessory protein UreG">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <sequence length="216" mass="23193" checksum="CD7B9CBF8202B10D" modified="2004-10-25" version="1">MNAPRFAAPARRTKKLPPLRVGIGGPVGSGKTTLLEMLCKGMRERYDLVAITNDIYTKEDQRLLTIAGALPEARIMGVETGGCPHTAIREDASINLEAVERMLARFPDADIVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPLVGANLEVMASDTRKMRGERPYVMCNLKALDGVADVIAFIENKGLLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RM1</accession>
    <name>Q63RM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527581.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109247.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2651"/>
    <dbReference type="EnsemblBacteria" id="CAH36659">
        <property type="protein sequence ID" value="CAH36659"/>
        <property type="gene ID" value="BPSL2651"/>
    </dbReference>
    <dbReference type="GeneID" id="56528546"/>
    <dbReference type="KEGG" id="bps:BPSL2651"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2694"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQPWSPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267483" evidence="1">
        <location>
            <begin position="28"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="435" mass="47289" checksum="9B0E16D8031EF32E" modified="2004-10-25" version="1">MKRRSLLKFGSMAGVMALAGQSPVARAADSGKGPIKVGILHSLSGTMAISETSLKDTALMTIADINKNGGVLGRPLQPVVVDPASNWPLFAEKARQLLTQEKVACVFGCWTSVSRKSVLPVFEELNGLLYYPVQYEGEEMSRNVFYTGAAPNQQAIPAVEYMMSAEGGGAKRFFLLGTDYVYPRTTNKILRAFLKSKGVKDSDIQEVYTPFGHSDYQTIVANIKTFAQGGKTTVISTINGDSNVPFYKELGNQGLKATDVPVVAFSVGEEELRGIDTKPLVGHLAAWNYFMSVKGPANAKFKEQFAAWVKSQNLPGGAKRVTNDPMEATFVGIHMWKQAVEKAKSTDVDRVRTAMIGQSVAAPSGFTLTMDGNHHLHKPVMIGEIRGDGQFNVVWKTKTAIRAQPWSPFIAGNQGKPDVVGSIPEFLRRRRAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RQ3</accession>
    <name>Q63RQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 1-aminocyclopropane-1-carboxylate deaminase</fullName>
            <ecNumber evidence="7">3.5.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.7" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522300.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109214.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2618"/>
    <dbReference type="EnsemblBacteria" id="CAH36626">
        <property type="protein sequence ID" value="CAH36626"/>
        <property type="gene ID" value="BPSL2618"/>
    </dbReference>
    <dbReference type="GeneID" id="56528581"/>
    <dbReference type="KEGG" id="bps:BPSL2618"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2735"/>
    <dbReference type="eggNOG" id="COG2515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YVFVACG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005966">
        <property type="entry name" value="D-Cys_desShydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01275">
        <property type="entry name" value="ACC_deam_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="35980" checksum="B9BF57A1D04C5B0C" modified="2004-10-25" version="1">MNTTTLSTKLNAFARLNLIDAPTPLQYLPRLSAHVGRDIHVKRDDCTPLAMGGNKLRKLEFLAADALGQNADVLVTAGAIQSNHVRQTAALAAQLGLGCVALLENPIAAARDDYLQSGNRLLLDLFDVRAHVVDGLDDVDRQLEAAARRLRDEGRRPYVIPIGGSNPLGALGYVRAGLELAQQIRAAERDFAAVVLASGSAGTHAGLAFALAHALPGLPVIGVTVSRTDAQQRPKVRHLLDGMSGLLDVALPAGARIDLWDDYFAPRYGEPNRAGIDALRLLARTEGLLLDPVYTGKAMAGLIDGVARGRFDGNGPVLFVHTGGAPALFAYQDACRASR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S39</accession>
    <name>RSGA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsgA</name>
        <name type="ordered locus">BPSL2483</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550124.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109078.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S39"/>
    <dbReference type="SMR" id="Q63S39"/>
    <dbReference type="STRING" id="272560.BPSL2483"/>
    <dbReference type="EnsemblBacteria" id="CAH36489">
        <property type="protein sequence ID" value="CAH36489"/>
        <property type="gene ID" value="BPSL2483"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2483"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2901"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CLVAAYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000216036" description="Small ribosomal subunit biogenesis GTPase RsgA">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="2">
        <location>
            <begin position="85"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="314" mass="34238" checksum="7F78E31F6C788381" modified="2004-10-25" version="1">MKRAPTKQPAKPAARGGERAQGRVIAAHGRHYIVAPADGGSMLQCFPRGKKSEVAVGDRVAYERTSADQGVIVEIGERRNLLYRSDQFKSKLFAANLDQLLIVLATEPYFSEDLLGRALIAAEANELKPIVVLNKIDVEAALPVARERLAPYRALGYDVLELSVKGAPDDARAQLAPRLAGHSTILLGQSGMGKSTLVNLLVPDAEAATREISAALNSGRHTTTFTRLYPLQDGGALIDSPGFQEFGLYHLTEGRLERAFPEFRPLLAHCRFYNCHHLHEPGCAILEALADGRIAPTRHALYAQLVHEASQIVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SA2</accession>
    <name>EFP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P</fullName>
            <shortName evidence="1">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">efp</name>
        <name type="ordered locus">BPSL2422</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193484.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109014.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SA2"/>
    <dbReference type="SMR" id="Q63SA2"/>
    <dbReference type="STRING" id="272560.BPSL2422"/>
    <dbReference type="EnsemblBacteria" id="CAH36425">
        <property type="protein sequence ID" value="CAH36425"/>
        <property type="gene ID" value="BPSL2422"/>
    </dbReference>
    <dbReference type="GeneID" id="56596337"/>
    <dbReference type="KEGG" id="bps:BPSL2422"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2968"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000094220" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <sequence length="185" mass="20792" checksum="85ABB92B1C270FD3" modified="2004-10-25" version="1">MKTAQELRVGNVVMIGNDAWVVSKTEYNKSGRNAAVVKMKLKNLLNGGGQESVYKADDKFEVVVLDRKEVTYSYFADPMYVFMDADYNQYEVEAEMMGDALNYLEDGMACEVVFYNEKAISVELPTILVREITYTEPAVKGDTSSGKVLKNAKLATGFELQVPLFCNTGDKIEIDTRTNEYRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SK4</accession>
    <name>Q63SK4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">DNA-binding transcriptional regulator NtrC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nitrogen regulation protein NR(I)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glnG</name>
        <name evidence="9" type="synonym">ntrC</name>
        <name evidence="12" type="ordered locus">BPSL2316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192209.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108912.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2316"/>
    <dbReference type="EnsemblBacteria" id="CAH36319">
        <property type="protein sequence ID" value="CAH36319"/>
        <property type="gene ID" value="BPSL2316"/>
    </dbReference>
    <dbReference type="GeneID" id="56596115"/>
    <dbReference type="KEGG" id="bps:BPSL2316"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3108"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWTGNIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010114">
        <property type="entry name" value="Transcript_reg_NtrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01818">
        <property type="entry name" value="ntrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="10">
        <location>
            <begin position="137"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="511" mass="55671" checksum="2105ED8BE97F92DD" modified="2004-10-25" version="1">MKPIWIVDDDQSIRWVLEKALARESFATRSFANVRDALAALDQETPQVLVSDIRMPGGSGLELLQAMHDRLPGLPVIIMTAFSDLDSAVAAFQGGAFEYLAKPFDVDKAVELIRRAVEESLRGGVPDDDKLAEAPEMLGQAPAMQDMFRAIGRLSHSAATVLITGESGTGKELVARALHRHSPRANGPFIALNTAAIPKDLLESELFGHERGAFTGAQTTRQGRFEQAENGTLFLDEIGDMPFDLQTRLLRVLSDGQFYRVGGHSPLRANVRVIAATHQNLEARVRQGLFREDLYHRLNVIRLRLPPLRERSEDIALLTRHFLQKSARDLGVEPKRVSDEALAYLTSLPFPGNVRQLENLANWLTVMAPAQTVEIKDLPPDLVATQTASGSMMPVEATVEAEAQASGLGVGAAEPHAPSAVAAVPATAGAPTAVGAPAGHPLWEHGLRTEVARLLRENSADVMDALARRFEAAVIREALDFTRGRKVEAAERLGIGRNTITRKIQELHLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV4</accession>
    <name>Q63SV4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199549.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108812.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2217"/>
    <dbReference type="EnsemblBacteria" id="CAH36219">
        <property type="protein sequence ID" value="CAH36219"/>
        <property type="gene ID" value="BPSL2217"/>
    </dbReference>
    <dbReference type="GeneID" id="56596004"/>
    <dbReference type="KEGG" id="bps:BPSL2217"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3228"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MMILAED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="6">
        <location>
            <begin position="45"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="321" mass="36120" checksum="24773F333AAF312D" modified="2004-10-25" version="1">MNATLEPSSPGGAAGASTSRMGHLDWLEAESIHILRELVAECSKPALLFSGGKDSVVVLHLALKAFGLGANRRTTLPFPLVHIDTGHNYDEVIDFRDRRAKQIGAELVVGHVEDSIARGTVVLRRETDSRNAAQAVTLLETIERHGYTAMIGGARRDEEKARAKERIFSFRDEFGQWDPKAQRPELWSLYNARLHRGEHLRVFPISNWTELDVWQYIAREKLELPSIYYAHRREIVRRNGLLVPVTPLTPMREGETSEQALVRFRTVGDISCTCPVESDADDVEKIIAETAVTEITERGATRMDDQASEAAMEQRKKQGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SW7</accession>
    <name>Q63SW7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fabI</name>
        <name evidence="10" type="ordered locus">BPSL2204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2014-10" db="PDB data bank">
            <title>Crystal structure of enoyl ACP reductase from Burkholderia pseudomallei in complex with AFN-1252.</title>
            <authorList>
                <person name="Rao N.K."/>
                <person name="Sarah J."/>
                <person name="Anirudha L."/>
                <person name="Subramanya H.S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191586.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108799.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="4RLH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.26 A"/>
        <property type="chains" value="A/B/C/D=1-263"/>
    </dbReference>
    <dbReference type="PDBsum" id="4RLH"/>
    <dbReference type="SMR" id="Q63SW7"/>
    <dbReference type="STRING" id="272560.BPSL2204"/>
    <dbReference type="EnsemblBacteria" id="CAH36206">
        <property type="protein sequence ID" value="CAH36206"/>
        <property type="gene ID" value="BPSL2204"/>
    </dbReference>
    <dbReference type="GeneID" id="56595991"/>
    <dbReference type="KEGG" id="bps:BPSL2204"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3243"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="4RLH"/>
        </source>
    </evidence>
    <sequence length="263" mass="27771" checksum="BEE6B7EDC0290628" modified="2004-10-25" version="1">MGFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVGGMAGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T33</accession>
    <name>Q63T33_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192895.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108733.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2138"/>
    <dbReference type="EnsemblBacteria" id="CAH36140">
        <property type="protein sequence ID" value="CAH36140"/>
        <property type="gene ID" value="BPSL2138"/>
    </dbReference>
    <dbReference type="GeneID" id="56595922"/>
    <dbReference type="KEGG" id="bps:BPSL2138"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3318"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TQIRAEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="Band_7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="33974" checksum="C1A8D9F06239F584" modified="2004-10-25" version="1">MDSLIVWVVLLVIAFVIVSQTVKIVPQQHAWVLERFGRYHATLSPGLNIVLPFVDRIAYRHVLKEIPLDVPSQICITRDNTQLQVDGVLYFQVTDPMKASYGSSNFVLAITQLAQTTLRSVIGKLELDKTFEERDFINHSIVSALDEAASNWGVKVLRYEIKDLTPPKEILHAMQAQITAEREKRALIAASEGRKQEQINLASGAREAAIQKSEGEKQAAINQAQGEAAAILAVAEANSQAIQKIAQAIQSQGGMDAVNLKVAEQYVGAFGNLAKAGNTLIVPSNLSDLSTAIASALTIVNRSAPGALAPGASKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T62</accession>
    <name>MSCL_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mscL</name>
        <name type="ordered locus">BPSL2107</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192898.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108704.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T62"/>
    <dbReference type="STRING" id="272560.BPSL2107"/>
    <dbReference type="EnsemblBacteria" id="CAH36110">
        <property type="protein sequence ID" value="CAH36110"/>
        <property type="gene ID" value="BPSL2107"/>
    </dbReference>
    <dbReference type="GeneID" id="56595896"/>
    <dbReference type="GeneID" id="66547433"/>
    <dbReference type="KEGG" id="bps:BPSL2107"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3365"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0407">Ion channel</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000237987" description="Large-conductance mechanosensitive channel">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <sequence length="143" mass="15578" checksum="1AC01FA32E425565" modified="2004-10-25" version="1">MSIIKEFKEFAVKGNVMDLAIGVIIGGAFSKIVDSVVKDLIMPVIGVLTGGLDFSNKFVLLGQIPASFKGNPESFKDLQAAGVATFGYGSFITVLINFIILAFIIFLMVKFINKLRKPEEAAPAATPEDVLLLREIRDSLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T66</accession>
    <name>Q63T66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108700.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2103"/>
    <dbReference type="EnsemblBacteria" id="CAH36106">
        <property type="protein sequence ID" value="CAH36106"/>
        <property type="gene ID" value="BPSL2103"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2103"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2384"/>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKSRFAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021957">
        <property type="entry name" value="DUF3574"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12098">
        <property type="entry name" value="DUF3574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="14583" checksum="6656E3F1B1E96320" modified="2004-10-25" version="1">MAVAALLPGCATSPQPASGDARCTQAGGTRELQADLLFGRDVAGRGPITDAQRARFVADAVTPRFPDGLTTWDTRGQWRDRETGRIVREESFVIRIIAPDSPATLDSLAAIRRAYAERFHQQSVGLVLARVCASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TA2</accession>
    <name>Q63TA2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108664.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2065"/>
    <dbReference type="EnsemblBacteria" id="CAH36066">
        <property type="protein sequence ID" value="CAH36066"/>
        <property type="gene ID" value="BPSL2065"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2065"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2331"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRLGEPW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="27032" checksum="2161A99D930E5103" modified="2004-10-25" version="1">MSRQKVVLIYLIEDDEVQARCYAAILQHAGYSVRVLPDGERALREIQRAAPDLIVLDRRLPDIDGLEIIAWVRERCAPLPILVLTNAVLETDLVEALEAGADDYLIKPPREREFVARVNALRRRASISKQFEGTIEIGGYRIATVERAVYLAGERIPLSPKEYEIVELLARHVGQVVPRKTIISRVWGRAAEEEVSRSLDTHIYRIRRKMNLSRRNGAMLRVIYTHGFRLDDFSHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TM4</accession>
    <name>RL35_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">BPSL1943</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191477.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108542.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TM4"/>
    <dbReference type="SMR" id="Q63TM4"/>
    <dbReference type="STRING" id="272560.BPSL1943"/>
    <dbReference type="EnsemblBacteria" id="CAH35942">
        <property type="protein sequence ID" value="CAH35942"/>
        <property type="gene ID" value="BPSL1943"/>
    </dbReference>
    <dbReference type="GeneID" id="60549753"/>
    <dbReference type="GeneID" id="62010906"/>
    <dbReference type="GeneID" id="64461436"/>
    <dbReference type="GeneID" id="67431690"/>
    <dbReference type="KEGG" id="bps:BPSL1943"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4087"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="PRO" id="PR:Q63TM4"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000258648" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <sequence length="65" mass="7301" checksum="EC6EBE6457044080" modified="2004-10-25" version="1">MPKMKTKKSAAKRFVVRPGGTVKRGQAFKRHILTKKTTKNKRHLRGATAVHDSDLNSVRAMLPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TV4</accession>
    <name>Q63TV4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193229.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108462.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1863"/>
    <dbReference type="EnsemblBacteria" id="CAH35862">
        <property type="protein sequence ID" value="CAH35862"/>
        <property type="gene ID" value="BPSL1863"/>
    </dbReference>
    <dbReference type="GeneID" id="56595655"/>
    <dbReference type="GeneID" id="66547020"/>
    <dbReference type="KEGG" id="bps:BPSL1863"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3997"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHINQVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029401">
        <property type="entry name" value="Nudix_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14803">
        <property type="entry name" value="Nudix_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="181" mass="20519" checksum="584C7734723EF9FF" modified="2004-10-25" version="1">MKFCSVCGHEVIARIPPGDNRERFVCDQCGTIHYQNPRNVVGTIPVWGDQVLLCRRAIEPRYGYWTLPAGFMEMGETTAEAAARETLEEAGARVEVQNLFTLLNVPHVHQVHLFYLARLVDPSFEAGEESLEVRLFDEADIPWDEIAFPTVSQTLRFFFADREAGDYGVHTGDIFRSLRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U40</accession>
    <name>Q63U40_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative L-ornithine 5-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554397.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108376.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1776"/>
    <dbReference type="EnsemblBacteria" id="CAH35775">
        <property type="protein sequence ID" value="CAH35775"/>
        <property type="gene ID" value="BPSL1776"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1776"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3883"/>
    <dbReference type="eggNOG" id="COG3486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YHGNTNY"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="468" mass="50995" checksum="BDD787B33B2AE5F2" modified="2004-10-25" version="1">MQRDTVFDLIGVGFGPSNLALAVRLAEAGEPAAFAHCYVERQPAFGWHRGMLLDDCRMQISFLKDLVTLRDPKSRFTFINYLYEHGRLSEFVNLKNFYPTRVEFHDYLSWVANAFDERVHYGETVTAIEPVAAPGAPGEIDALRVVSKGADGRERQRVARALSVGVGGAPSVPDAFAALGPECVVHSSSYLTSIERLVGAPGAHARKRIAVIGAGQSAAEVFVDLARRFPDVEASLVIRSGALKPADDSPFVNEIFNPAFTDVVYAQPASGRRSLIERFRDTNYAVVDRPLIEQIYEMLYLQRVAGEAPGAPRHRLLANTAIESAARTAHGQVELALRDRLTGDARTERFDGLVLATGYRRDTHLPLLEGLAPHLGDALAAGDVARDYRLATPAHFKPRIYLQGCCEDSHGLSDTLLSVLARRADEIAASLADAADTTEYEEADPAAGRARPRHENNGVSDGRLAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U45</accession>
    <name>Q63U45_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalamin biosynthesis related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526953.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108371.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1771"/>
    <dbReference type="EnsemblBacteria" id="CAH35770">
        <property type="protein sequence ID" value="CAH35770"/>
        <property type="gene ID" value="BPSL1771"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1771"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3877"/>
    <dbReference type="eggNOG" id="COG2073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CIAPDRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="14697" checksum="C506373F9A5AE67F" modified="2004-10-25" version="1">MMRVALGIGCRAGRPAEAIEAAIRAALARLPQASLADVGVVATLDAKAREPGLVACCARHGWPLVAFSRDEIAAHLARLAGLARAGSDSGSGSGVGASPAPGAPPCAAARARFGVDGVCEPCACLAAPNGALIVRKLALDGVTAALAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U50</accession>
    <name>Q63U50_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205063.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108366.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1766"/>
    <dbReference type="EnsemblBacteria" id="CAH35765">
        <property type="protein sequence ID" value="CAH35765"/>
        <property type="gene ID" value="BPSL1766"/>
    </dbReference>
    <dbReference type="GeneID" id="56595553"/>
    <dbReference type="KEGG" id="bps:BPSL1766"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3870"/>
    <dbReference type="eggNOG" id="COG1240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQWLWQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="204" mass="22108" checksum="E89AC71D6A14FCE6" modified="2004-10-25" version="1">MRHDDARGRPGTRIAWRATLAAKRGEAWRADHLRYRPQAGSPGALHCFVLDCSASMLTAERLARAKGLVVALFDSLARERADAALVCFGGNAADVRFGPAVPRWWNERWLAPVGAGGGTPLTRGIGAATRLLARAARRHPGQQRWLWLLSDGRTTESPARPALAERIVIVDFDDAPVRLGRCERLAHAWGAALVTPQALERGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UA5</accession>
    <name>Q63UA5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carbamoyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534894.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108311.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1711"/>
    <dbReference type="EnsemblBacteria" id="CAH35710">
        <property type="protein sequence ID" value="CAH35710"/>
        <property type="gene ID" value="BPSL1711"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1711"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3802"/>
    <dbReference type="eggNOG" id="COG2192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YDASKVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0536">Nodulation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_N" evidence="3">
        <location>
            <begin position="133"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="4">
        <location>
            <begin position="401"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="573" mass="63426" checksum="422133A7F741328C" modified="2004-10-25" version="1">MYILGINAAYHESAACLVKDGQVVMAIEEERLNRIKHGKLSTPETTGQLPWKAIRKCLDAAGIGLDACAHIGYSFSPDILQKGVASWRSANGGAHAWPLDKESYQTLEGGLNFAEGVLSSRRQLIEDAGFAGEFHFLPHHDCHAASAFHVSPFEKAAVLVVDGIGEWASTSLYHGDGTTLGKVHDFLFPNSLGFVWEKLSKYLGFSQYDASKVMGLAAYGDGAKTIELFSRIVTDKENMSVDLAVLRHESPDFTTLEALFGLPRRHTPVDFDTDNWQAYVDVAAGLQLLTEQVLLHILRKFDRTTYRHLCMAGGVALNCAANGVIVREKLFDDVFIQPASNDAGTAMGAAFLIWNQVLGHPREYVFNHAYLGPEYSDGEIEAVLRRTNLAYRKVDIEKEVAQLIANGSIVGWFNGRMEWGPRALGGRSLLADPRNKAVRELMNVKVKHRELYRPFCPSILGERAEEWFEGSASVAAGKYMLTTSRVRAEKAERIPAVVHFDGTVRAQTVYAQDNPRYHRLIAEFDALTGVPLLLNTSFNDSEPIVCTPQDAINTFMKTDIDYLALGSYLISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UG4</accession>
    <name>Q63UG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108252.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1642"/>
    <dbReference type="EnsemblBacteria" id="CAH35639">
        <property type="protein sequence ID" value="CAH35639"/>
        <property type="gene ID" value="BPSL1642"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1642"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1853"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SAIMNFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="28524" checksum="71BD1C5147AC82B1" modified="2004-10-25" version="1">MFQRVGFGGPMRRAGFRPFIFLPPMSNLKIERNAKTLRELTLDKLRGAIVQGYFRPGERLVERTLCDELGVSRTVVREVLRHLETEGLVEIAVGHGPIVARLDPALIGEIYELRGLLEANVARACAERATPELVAKLRNIRTMIEDAFDKEDLSRVLEHTEQFYDAMFEGAGKQVSLTVVKSLNARINQLRALTIAVPGRSGESNREMNALLDAIERQDPEGASAASAAHIRRAAELALNALEEKQKEEEQVRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UJ6</accession>
    <name>Q63UJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527105.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108220.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1604"/>
    <dbReference type="EnsemblBacteria" id="CAH35604">
        <property type="protein sequence ID" value="CAH35604"/>
        <property type="gene ID" value="BPSL1604"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1604"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3663"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWSYVYF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="29155" checksum="A7BA03C983624E6F" modified="2004-10-25" version="1">MSTLTSRPLWAQIRVIAGKEFHDRIRNRWVLAISIVFAAFTLAISYFGAAAQGAVGFHGIEPLIASLVSLAIYLLPLIALILGFDALVGERERGTLSLLLSYPLTRTELLVGKYVGLAAALTCATLAGFGAAGAVIAARMSAADWYQYAGFVLSAVLLGWVFLSLAVCASAFCASRTSASGVAIALWFCFVLVYDLLLLGALVLTGGAGLGPALPLLLLLNPADVFRVLNIFGPGDLRAMFGAVSAFPAALASPLLLGPVMLAWIAAPLGLAAWRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UM3</accession>
    <name>Q63UM3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108193.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35574">
        <property type="protein sequence ID" value="CAH35574"/>
        <property type="gene ID" value="BPSL1573"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1573"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1770"/>
    <dbReference type="eggNOG" id="ENOG5033BI2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FYGVRTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="16337" checksum="63BDDF97E8E63594" modified="2004-10-25" version="1">MPRRAGSRAVTALHMPVRFIGADRMLDRPETVSYLLASALFFALAVPLAAQRIAPNRFYGVRTRATLRNPALWYRRNRVFGVALMITSATFIVVAEYCRLRGVRLPDAALLAAFVAEIAVPIAVCFAAGRPPETPETPSRRAGDGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UN8</accession>
    <name>Q63UN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">potI</name>
        <name evidence="6" type="ordered locus">BPSL1558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193032.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108178.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1558"/>
    <dbReference type="EnsemblBacteria" id="CAH35559">
        <property type="protein sequence ID" value="CAH35559"/>
        <property type="gene ID" value="BPSL1558"/>
    </dbReference>
    <dbReference type="GeneID" id="56595701"/>
    <dbReference type="KEGG" id="bps:BPSL1558"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3604"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NKFGMKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="272" mass="29927" checksum="61EF2149796B1C31" modified="2004-10-25" version="1">MKPNRYLQVLMLAIGFGFLYIPIASLVVYSFNDSKLVTVWSGFSTRWYAALVEDDELIAAAWLSLKIAVMTAFASVFIGTWAGFVLARMGRFRGFALYSGMINAPLVIPEVIQGISLLLLFIELGKWFGWPAGRGMFTIWLGHVMLCISYVAIIVQSRVRELNPSLEEAALDLGATPFRVFFSITLPLISQALVSGWLLSFTLSIDDLVLSAFLSGPGSTTLPLVVFSRVRLGLNPEMNALATLFIVAVTIGVVAANYVMLRQEKRRMAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UR5</accession>
    <name>Q63UR5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamD</name>
        <name evidence="3" type="ordered locus">BPSL1531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamD family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937181.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108151.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1531"/>
    <dbReference type="EnsemblBacteria" id="CAH35532">
        <property type="protein sequence ID" value="CAH35532"/>
        <property type="gene ID" value="BPSL1531"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1531"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3571"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VERQHPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15830">
        <property type="entry name" value="BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00922">
        <property type="entry name" value="OM_assembly_BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019280" description="Outer membrane protein assembly factor BamD" evidence="1">
        <location>
            <begin position="27"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="2">
        <location>
            <begin position="43"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="30619" checksum="9A2C4CB6167723C9" modified="2004-10-25" version="1" precursor="true">MMHSTKRVAKPAAAWAVLAAAAALVAGCHGLPQKSDETATWSNNKLYSEAQDALTGGDWGKCAKYFEALQGRDPFGHFAQQAQINVAYCNWKDNETAAADQAVDRFIQLHPDHPDVAYAYYLKGMIHFNDDLGLFGRFSGQDMSERDPQALRESYDAFRAVVDRYPKSKYAPDAAARMRYIVNALASHEVHAADYYYRRGAYVAAINRAQLAIKEYKNAPAIEDALHIMMLSYAKLNQPQLADDTKRVLASTFPDSPYVTGHARPGSKKSWWQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-06-13" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UT0</accession>
    <name>BAMB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamB</name>
        <name type="ordered locus">BPSL1516</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193323.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108136.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UT0"/>
    <dbReference type="SMR" id="Q63UT0"/>
    <dbReference type="STRING" id="272560.BPSL1516"/>
    <dbReference type="EnsemblBacteria" id="CAH35517">
        <property type="protein sequence ID" value="CAH35517"/>
        <property type="gene ID" value="BPSL1516"/>
    </dbReference>
    <dbReference type="GeneID" id="56595745"/>
    <dbReference type="KEGG" id="bps:BPSL1516"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3553"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRVLWQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00923">
        <property type="entry name" value="OM_assembly_BamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017687">
        <property type="entry name" value="BamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03300">
        <property type="entry name" value="assembly_YfgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000417678" description="Outer membrane protein assembly factor BamB">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00923"/>
        </source>
    </evidence>
    <sequence length="381" mass="39843" checksum="7B40A83F23C5A372" modified="2004-10-25" version="1" precursor="true">MNLLKRYAAPVACAAAVLVFAACSSTKDARRVPTPLTEFKPVLDVQQVWTASVGKGGRYSFSPVAVGDAVYVAGANGSVEKIDAKTGQQVWRTKIGSDLSAGVGSDGNLTAVGALKGGVFVLGPDGKQLWKATVQGEIFSPPLVGNGLVIVRTIDGQVIAFAAQTGEQKWTYRNRAVPLNLRVSAGMTFAGDAAVLAGFPGGGLVALNLQTGEPFWQTPVSFPKGVTEVERINDVTGAPTLVGAETCAVTFQGQLGCFDANSGRPLWEKPFSSRSGVAQDDTVVVGGDDWSVVSAYDVATGKALWRNDKLKSRDVGVPYLLGRAVVLGDYKGFVHFLSRDDGTFVARMKTDGSAIAAAPVLAGNTLVVLTQDGGVYGFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UZ5</accession>
    <name>Q63UZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521293.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108071.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1449"/>
    <dbReference type="EnsemblBacteria" id="CAH35451">
        <property type="protein sequence ID" value="CAH35451"/>
        <property type="gene ID" value="BPSL1449"/>
    </dbReference>
    <dbReference type="GeneID" id="56529173"/>
    <dbReference type="KEGG" id="bps:BPSL1449"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3475"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQYHDVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="156" mass="16453" checksum="1CB500423C5C5742" modified="2004-10-25" version="1">MGLLSFIKEAGEKLLGKSDEQAATDPAAANQTAADAIKNYISAQGLDTSNLTVAFDGASRTVTLTGSVADLDTKAKVKVAAGNVQGVAGVNDDDLQPDDPQVQYHDVVSGDNLWKIAEKYYGDGSKNDAIFQANRPMLSSPDRIYPGQKLVIPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V03</accession>
    <name>Q63V03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108063.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1441"/>
    <dbReference type="EnsemblBacteria" id="CAH35443">
        <property type="protein sequence ID" value="CAH35443"/>
        <property type="gene ID" value="BPSL1441"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1441"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1616"/>
    <dbReference type="eggNOG" id="ENOG5032CW5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASCGAYI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041238">
        <property type="entry name" value="Rap1a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18602">
        <property type="entry name" value="Rap1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266361" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Rap1a" evidence="2">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="116" mass="12154" checksum="CCB098752CDB29BB" modified="2004-10-25" version="1">MRAMFCAAAFAVPLTAAAFTAGDLDKLCAKTDVKSRASCAAYIEGAADGVYNTIDAIGGTTGPRVGQYFCLPPDIKAQQMTDAVRKYIAENPKLADYNASTAVSLGLGKAFPCRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V07</accession>
    <name>Q63V07_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192693.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108059.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1437"/>
    <dbReference type="EnsemblBacteria" id="CAH35439">
        <property type="protein sequence ID" value="CAH35439"/>
        <property type="gene ID" value="BPSL1437"/>
    </dbReference>
    <dbReference type="GeneID" id="56595827"/>
    <dbReference type="KEGG" id="bps:BPSL1437"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3459"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRGHAWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="344" mass="37052" checksum="49F0ADC8DE470F8C" modified="2004-10-25" version="1">MIYPWQTDDWNRLQALRAHWPHALLLYGQAGIGKLAFARHLAKGFLCETPRENGEPCGACAACTWFEQGNHPDYRIVVPEALAAELPGAADEPKAADADEGGKKARTPSKEIKIEQVRALVDFCGIASHRGGARVVVLYPAEALNVAAANALLKTLEEPPSGVVFLLASARVDRLLPTIVSRCRQWPMAVPAPDAAAAWLAAQQVADANALLAEAGGAPLAALALANDENRPLRDWTLAQLAAGAACDPFACGETLQKLPVPVVLGWLQRWLYDLLAERAAGAPRYFPAQRAALARCAAAADANAFARFLKTVTRQRAVENHPLSARLVFEELFLGYRELFASP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VY4</accession>
    <name>PURT_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formate-dependent phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="1">6.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-phosphoribosylglycinamide transformylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Formate-dependent GAR transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GAR transformylase 2</fullName>
            <shortName evidence="1">GART 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-folate glycinamide ribonucleotide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylglycinamide formyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purT</name>
        <name type="ordered locus">BPSL1111</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:24830"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.21" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522466.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107732.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VY4"/>
    <dbReference type="SMR" id="Q63VY4"/>
    <dbReference type="STRING" id="272560.BPSL1111"/>
    <dbReference type="EnsemblBacteria" id="CAH35104">
        <property type="protein sequence ID" value="CAH35104"/>
        <property type="gene ID" value="BPSL1111"/>
    </dbReference>
    <dbReference type="GeneID" id="56526730"/>
    <dbReference type="KEGG" id="bps:BPSL1111"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.439"/>
    <dbReference type="eggNOG" id="COG0027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMVTMIT"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043815">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase 2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01643">
        <property type="entry name" value="PurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005862">
        <property type="entry name" value="PurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01142">
        <property type="entry name" value="purT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000319141" description="Formate-dependent phosphoribosylglycinamide formyltransferase">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
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        </location>
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            <begin position="25"/>
            <end position="26"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <begin position="164"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
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        </location>
        <ligand>
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        </ligand>
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            <position position="365"/>
        </location>
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            <end position="373"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01643"/>
        </source>
    </evidence>
    <sequence length="404" mass="43083" checksum="8DBB650E67D908AD" modified="2004-10-25" version="1">MQIGQRLGTPLSPSATRVMLLGAGELGKEVIIALQRLGVEVIAVDRYPNAPGHQVAHRAHVIDMTDPDALRALVDAERPHLVVPEIEAIATDALAAIEAAGVCEVIPTARATQLTMNREGIRRLAAEELGLPTSPYAFAQSFDEFAAAVARIGFPCVVKPVMSSSGKGQSVVRSEADIEPAWRYAMAGGRVNHGRVIVEGFIRFDYEITQLTVRAIDPASGQTRTSFCAPIGHLQVAGDYVESWQPQPMSAKALERSRDIAHRVTSALGGRGIFGVELFVRGDDVWFSEVSPRPHDTGLVTLASQRQSEFELHARAILGLPVEPALATPAASAVIYGGLDEAGIAFEGVRDALAVPGADLRLFGKPESFAKRRMGVALATGANVDEARERAKRAAAAVRPVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W92</accession>
    <name>Q63W92_BURPS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">BPSL0996</name>
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        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
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            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
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                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0996"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="27024" checksum="EFC93024C1021FF0" modified="2004-10-25" version="1">MKTVLTHIVRRKQRYAALPLFAALRDERLPPRVRLGFMPAFAFFVMAFGDLNRYLLRKEPAHDPHQARVNAHTREDDHHWPWFLEDLEKLGWSRDTTFTEALRALWSDDTHRCRLLMYELCAIVDTADGVERLAIVEAIEETGNVLFALTTRLAGEVQAQTGRELRYMGAHHVALENGHMQNGEHAQLIGIELDAAKRRRCVALVDRVFDAFDAWTHEAAREIGRLAAPPALQETP</sequence>
</entry>
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    <accession>Q63WA7</accession>
    <name>Q63WA7_BURPS</name>
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        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family</fullName>
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        <name evidence="2" type="ordered locus">BPSL0981</name>
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    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
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            <taxon>Betaproteobacteria</taxon>
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            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0981"/>
    <dbReference type="EnsemblBacteria" id="CAH34977">
        <property type="protein sequence ID" value="CAH34977"/>
        <property type="gene ID" value="BPSL0981"/>
    </dbReference>
    <dbReference type="GeneID" id="56596209"/>
    <dbReference type="KEGG" id="bps:BPSL0981"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.593"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRHTSVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017578">
        <property type="entry name" value="Ribazole_CobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03162">
        <property type="entry name" value="ribazole_cobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="21162" checksum="6976769E5D9FCBB1" modified="2004-10-25" version="1">MDVVLIRHPAVALGTGVCYGASDVPLAAGAAAGAAGIRRRLRSLGVARASRVWSSPLARCADVARALAGGVRAPLEIDPRLREIDFGAWEMQSWDAIGRDALDRWSADLMHAREHGGESAAQFVARVRPAFATLAVAARTSWVLTHAGVIRALASHALDAPLDAMLARPIAMGGIVWLRCDEGGDSDCARGWRIAHWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB3</accession>
    <name>Q63WB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0975</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
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            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193419.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107603.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0975"/>
    <dbReference type="EnsemblBacteria" id="CAH34971">
        <property type="protein sequence ID" value="CAH34971"/>
        <property type="gene ID" value="BPSL0975"/>
    </dbReference>
    <dbReference type="GeneID" id="56596215"/>
    <dbReference type="KEGG" id="bps:BPSL0975"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.599"/>
    <dbReference type="eggNOG" id="ENOG5033KGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SQRHNEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="116" mass="12905" checksum="655D7468E7CEBEAD" modified="2004-10-25" version="1">MLNELETLSQNIGRLIALNQRHQTERLALEEQVAQLRNEAQTLHAELEQLRDERNALAAERDTLSAKIDDAQVKLNAILEKLPRTKNVPDAENQLDLLAPQANDEGEGATGHGEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WI9</accession>
    <name>Q63WI9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543966.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107527.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0900"/>
    <dbReference type="EnsemblBacteria" id="CAH34894">
        <property type="protein sequence ID" value="CAH34894"/>
        <property type="gene ID" value="BPSL0900"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0900"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.682"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THVPYAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="27"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="458" mass="48939" checksum="7D4BC68B24E9CFD9" modified="2004-10-25" version="1">MTQQQRTFDSIVEREKGLRRGLSSAQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYAIGALIALLLMGALAEMTVAHPTSGSFGAYAEHYVGPLAGFLVRYAYWSAVVFAVGTEVSAIAVFMKYWYPGVPGWYWVVGFSAVLIAVNMTSVTLYGVVEYVFSMLKIAAIVAFIALGAYFVAAAPVSSGIGFANYSAHGGFFPKGFSGVWVAVIVAIFSYMSIETVAIAAGEARDPQRAVSRAFRSTVFRLVLFYLLTLALMLAIVPWTQAGTDESPFVKVMAATHVPYAAGVINFVVLVAALSAMNSQLYVTTRMMFSLSRARLAPAMFGRVGANGVPLAALAVSSSGVAVAAVLVALYPQTAFTLLMAIAMFGALFTWLMIFVTHLRFRARYRGPTPVFRMWLHPAGSLTGAALVGAVLVTTAFTREFRMTMMVGVAFIVLLTLAYRWHYRARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WQ3</accession>
    <name>Q63WQ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Xylulose kinase</fullName>
            <shortName evidence="3 4">Xylulokinase</shortName>
            <ecNumber evidence="3 4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dalK</name>
        <name evidence="3 4" type="synonym">xylB</name>
        <name evidence="7" type="ordered locus">BPSL0839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522654.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107463.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63WQ3"/>
    <dbReference type="STRING" id="272560.BPSL0839"/>
    <dbReference type="EnsemblBacteria" id="CAH34830">
        <property type="protein sequence ID" value="CAH34830"/>
        <property type="gene ID" value="BPSL0839"/>
    </dbReference>
    <dbReference type="GeneID" id="56526982"/>
    <dbReference type="KEGG" id="bps:BPSL0839"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.762"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HILLPHD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="253"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="493" mass="51745" checksum="25732244A62AC0C1" modified="2004-10-25" version="1">MYLGIDLGTSEVKVLLLSPDGAVVGTAGTPFTVARAHPRWAEQHPDDWWAGTLAALAALRARHPQAFAAVRGIGLSGQMHGAVLLDSGDRVLRPAILWNDMRSADECALLEARAPELHAIAGNLAMPGFTAPKLLWVARHEPDVFGRIACVLMPKDYLRLKLTGEKVSDPSDAAGTLWLDAARRDWSGALLAAGGMTRAQMPRIVEGNAPSGTLRADVARALGLAESVVVAGGGGDNATSALGIGATQPGDGFVSLGTSGVLSVVGDRFRPNPASAVHAFCHAIPERWQQMSVVLSAASCLRWVCKLTSTDEPALLAEIAALDPAARENAPLFLPYLSGERTPHNDPYAQGVFFGMTHGTERALLGYAVLEGVTLALADGFDALIAGGTQTDALSLIGGGARSAYWAQLIADALGVRTRRHGGGETGAALGAARLGWLAVGGAPRDVLAKPPLRDEFAPDAARHAALRARLDAFRALYRHVRPLFEPSRARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WR5</accession>
    <name>Q63WR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fructokinase</fullName>
            <ecNumber evidence="2">2.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scrK</name>
        <name evidence="2" type="ordered locus">BPSL0827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.4" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555973.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107451.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63WR5"/>
    <dbReference type="STRING" id="272560.BPSL0827"/>
    <dbReference type="EnsemblBacteria" id="CAH34818">
        <property type="protein sequence ID" value="CAH34818"/>
        <property type="gene ID" value="BPSL0827"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0827"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.774"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLWKGRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="318" mass="32399" checksum="27AA1C45BDD65DE9" modified="2004-10-25" version="1">MAAIVAAGELLAEFVAAKRGQGFDAPGEFAGPFPSGAPAIFADQAARMGASVAYAGCVGRDAFGDAIVARLASHGVDVAHIRRAARPTGIACVAYRADGGRQFVFSIDGSASALLEPADVVPSMFAGCRYFHVMGSSLTSENAIAAVKRGVIEAARVGAKISFDPNVRAEMLAFAPMRAALREMLDACHLFLPSEADLPFFCGPQPAERAIAGLLATHPLLERVVLKRGAAGSAAFDRTGSVAAPAYETAEVDPTGAGDCFGGTFVACAIAGLPVASALARANAAGALAVSRIGPMEGNSMPADIDRFLAERGARCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X23</accession>
    <name>Q63X23_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL0717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526169.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107343.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0717"/>
    <dbReference type="EnsemblBacteria" id="CAH34709">
        <property type="protein sequence ID" value="CAH34709"/>
        <property type="gene ID" value="BPSL0717"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0717"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.896"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="155"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="383"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="451" mass="48488" checksum="BC7A92FFA5BD657F" modified="2004-10-25" version="1">MRAKPACTRALLADLYEFTMLQSYFDCGMNDTATFELFVRRLPAHRNFMMAAGLEQALDYLANLAFDADEIEALAGMGLFGDGFLASLASLRFTGTVRAMREGTVFFADEPILQVTAPLREAQLIESRVMNLLHYETIVASKAARAVLAAPGRALVDFGLRRAHGAEAALLSARASYVAGFAGTATLLAGLRYGIPTYGTMAHSYVQAHDDEALAFEHFARSFPRNAMLLVDTYDTEAAAGKVIEVARRLARDGVEVKGVRLDSGDLAQHAMRVRAQLDRAGLGRVTLFASGNLDEYRLAELIGQGAPIDGFGVGTRMNTSADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVFRRYRDDGLLDGDCLALHDDAQAGVALLEPVMIGGERVAPSPSLADVRAHARAQLDTLPAALRDLARAAEYPVAVAGTLAALAQRLDARAASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X28</accession>
    <name>Q63X28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526161.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107338.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0710"/>
    <dbReference type="EnsemblBacteria" id="CAH34703">
        <property type="protein sequence ID" value="CAH34703"/>
        <property type="gene ID" value="BPSL0710"/>
    </dbReference>
    <dbReference type="GeneID" id="56527080"/>
    <dbReference type="KEGG" id="bps:BPSL0710"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.905"/>
    <dbReference type="eggNOG" id="COG2603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RPLVYCW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043828">
        <property type="term" value="F:tRNA 2-selenouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017582">
        <property type="entry name" value="SelU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03167">
        <property type="entry name" value="tRNA_sel_U_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="359" mass="39857" checksum="DD3EBBDBA6FB6375" modified="2004-10-25" version="1">MNLQPASLAQIDDFDEIVDVRTPLEYAEDHIPGALNAPVLSNEERVIVGTMYKQVSPFEATRVGAAMVARNIAAHLDTTFADRPRNWRPLIYCWRGGKRSGSMTVWFNMIGWRARQLDGGYKTYRRSIVDALGELPAGFRYVVLAGHTGSGKTRLLHALARAGAQTLDLEALAAHRGSLLGALPSGEQPSQKAFDTALVSALRGFEHDRPVFIEAESRRIGAITLPLALLAGMHAADCVKVETARDERVELLLQDYGHLFDQPAFFKIQLEKLVPLHGHARIRKWHAMLDEGRRGELFEELVDVHYDPAYTRSSGAHFARLPQAERFAFRPTARDVVEQARALLAHLDAAGARALDKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X64</accession>
    <name>Q63X64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative PhoH-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoH family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522785.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107302.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0673"/>
    <dbReference type="EnsemblBacteria" id="CAH34666">
        <property type="protein sequence ID" value="CAH34666"/>
        <property type="gene ID" value="BPSL0673"/>
    </dbReference>
    <dbReference type="GeneID" id="56527116"/>
    <dbReference type="KEGG" id="bps:BPSL0673"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.946"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHPFDQP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="143"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="354" mass="39287" checksum="5550CF1DABC1859E" modified="2004-10-25" version="1">MKTAQALEFTAPRDDNARLANLCGPLDENLRQIEQALDVTLSRRGHRIAIRGRGAKIALAALEDFYNRAREPLSVDDIQLALVEARHPGNPRRNGNGDGEPEIDVRFRGDPDHPFDEPVVRLGDEPPADEAAPKLYTRRADLRGRTPAQREYLKQILSHDVTFGVGPAGTGKTYLAVACAVDALERDQVKRIVLTRPAVEAGERLGFLPGDLAQKVDPYLRPLYDALYDLLGFDKTAKMFERQMIEIAPLAYMRGRTLNHAFIILDEAQNTTPEQMKMFLTRIGFGSKAVVTGDTSQVDLPRGHKSGLVEAQQVLGGVRGIALTRFTSADVVRHPLVARIVEAYDEFHAQHKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XB6</accession>
    <name>Q63XB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferases group 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107249.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0620"/>
    <dbReference type="EnsemblBacteria" id="CAH34613">
        <property type="protein sequence ID" value="CAH34613"/>
        <property type="gene ID" value="BPSL0620"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0620"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.673"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VKFLDYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="381" mass="41671" checksum="FFFD47335FE18AA3" modified="2004-10-25" version="1">MLRDAPPRAAFAGDHAGVAALPRPVAINGKFTSQRLTGVQRVAHEFTSALARLLPGERNPTLVVPRDHASDTLPPTVARRVVPRLRGALWEQLALPFATRGQTLVSLCNIGPLFKRNQVVMIHDVAVLDFPQGYSLKFRLWYRFAFWMLKRRARHILTVSRFSKERIVARLGVAPTDVSTIVSGVDHFGRIEGDPSVLDRLGLAYDGYVLIVGSLAPGKNLARTLEAIARLERMRPELRFVIAGGSNVRIFGASALGERASAGNVTWAGYVSDGELKALYENAGCFVFPSLYEGFGLPPLEAMYCGCPVIVSREASLPEACGDAALYCDAHDAIDIAATIAQLMGDAELRRELREKGRARASRYRWDAAAKQLIGVLRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XE3</accession>
    <name>Q63XE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107222.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0593"/>
    <dbReference type="EnsemblBacteria" id="CAH34586">
        <property type="protein sequence ID" value="CAH34586"/>
        <property type="gene ID" value="BPSL0593"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0593"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.641"/>
    <dbReference type="OMA" id="FRHEATH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="145" mass="15243" checksum="DC16062829399A5F" modified="2004-10-25" version="1">MPPTTLLSTNDAAQGSAETNMSSSDLIQPRQVLVSIASATATYTALSPHVPGFLHVVAQGEAPLHVGNIHLAHDPGFVGGVLLEVVGIAGRPSPTVKQYRTPAYSFESCYHREIFIRGANGIIPVKVGLFRREAAQAAEAALDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XF0</accession>
    <name>Q63XF0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL0586a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936300.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107215.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34579">
        <property type="protein sequence ID" value="CAH34579"/>
        <property type="gene ID" value="BPSL0586a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0586a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1054"/>
    <dbReference type="eggNOG" id="ENOG502ZVUT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANGMENC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="26044" checksum="3DC75B4FB9E80994" modified="2004-10-25" version="1">MKKRTFLKNQLINAWTECVKYDYPTGVINGERALQACLYHRLINDFKANGMENCRRIFIEPTIDVKGRTSRRIPDMMICDTNNVIAIFELKFHPRVTLSGRFGDALRGGVEKDLDTLLSIAQDLNGVSAKPQADASHIEVSNERYLGVSGASKTYGLASNLMLVWAGIYKRSDRSDASSTERLARVFDDAGVTIQGGFLELHAQTQEEAHPVLVDRYSGWKTPRILYGDATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XG8</accession>
    <name>Q63XG8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936280.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107197.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0571"/>
    <dbReference type="EnsemblBacteria" id="CAH34561">
        <property type="protein sequence ID" value="CAH34561"/>
        <property type="gene ID" value="BPSL0571"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0571"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1077"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTIDEHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="620" mass="68348" checksum="194BFC00CB195644" modified="2004-10-25" version="1">MTYPALERYQEVLQFPKTAFRGDAELAQGSVARDGFGLPLVMCGGFALTYTFTLAQNRKVALRCFHKESKDLEDRYTAVARHLETLRSPYFVRFNFARNGIWVDGTAYPIVKMEWASGVTLGEFVEQYYDDRTRLARLIEALRRLAQYLESQGIAHGDIQPGNLMVSPDGASVRLIDYDGMFVPALAGMHSAEIGHRNFQHPGRDHTLFNAKLDRFAFISLDIALRAISAAAELWGHTNSDADAFVFRANDFASPQSSRVFASLSRIGELARDVASFATICLAGADRVPSLADFILGQGIPTGPRYLAPELGAKFARGRYLPSHPVVDASNFAAALDELDEVVELVGMVVDVANKKTKDGNNRPYAFINFGDWRPGNSVRLTIWDDVLRKMKIKPQSSWKGRWLSVKGQIRRRRERDGRVYVQLVVSAPGQIHTIDEHEARYRMDSERPDAMKDSPSPRVSSTDNRKLLAGMSANQPAPQEPKAQRPSPVQTNISTGATAANAQRLAQMKMKAQQQAPTVAMAARNPRPSPPTKITQNPPSSTPAPRPVVPQPMSAPRPIPQPVERGHREPPAAASPAATTTPTYQQAPFNSKSGRQAVPGWVYVAGGLFLLALVMLVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XM5</accession>
    <name>Q63XM5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ordered locus">BPSL0514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522862.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107140.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0514"/>
    <dbReference type="EnsemblBacteria" id="CAH34504">
        <property type="protein sequence ID" value="CAH34504"/>
        <property type="gene ID" value="BPSL0514"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0514"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1133"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="246"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="327"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="391"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="439" mass="46313" checksum="9E02D7AD5B10396A" modified="2004-10-25" version="1">MFSFFKRFKKAPDAAPAEPQQAPDAPRDASRAPASPDAARVDAPAAPQPRDERSENHDRPEHDETPTAEHSRSGAQPAARATPPASAAASEAPVGQPRAAAARASEPAPSVVMTVTPSSNGRHGVVETVEIVPPPAPEPAAKKSWIARLKSGLAKTSSSITNVFVNTKIDDALYEELETALLMSDAGIDATEHLLGALREKVRAGRLTDPQQVKDALRGLLVELLAPLEKSLVLGRAQPLVMMIAGVNGAGKTTSIGKLAKHLQSFDQSVLLAAGDTFRAAAREQLAIWGERNNVTVVQQESGDPAAVIFDAVSAARARNIDVMMADTAGRLPTQLHLMEELRKVKRVIGKAHDGAPHEVLLVIDANTGQNALAQVKAFDDALGLTGLIVTKLDGTAKGGILAAIARQRPIPVYFIGIGEKVEDLQPFSAEEFADALLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XZ2</accession>
    <name>COAX_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type III pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaX</name>
        <name type="ordered locus">BPSL0397</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550942.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107023.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XZ2"/>
    <dbReference type="SMR" id="Q63XZ2"/>
    <dbReference type="STRING" id="272560.BPSL0397"/>
    <dbReference type="EnsemblBacteria" id="CAH34385">
        <property type="protein sequence ID" value="CAH34385"/>
        <property type="gene ID" value="BPSL0397"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0397"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1268"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NSFIKWR"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000270867" description="Type III pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <sequence length="259" mass="27078" checksum="C94199EA78AE85D8" modified="2004-10-25" version="1">MSGMCLLIDAGNSRIKWALADTARHFVTSGAFEHASDAPDWSTLPAPRGAWISNVAGDAAAARIDALIEARWPALPRTVVRASAAQCGVTNGYAEPARLGSDRWAGLIGAHAAFADEHLLIATFGTATTLEALRADGHFAGGLIAPGWALMMRSLGMHTAQLPTVSIDAATNLLDELAENDAHAPFAIDTPHALSAGCLQAQAGLIERAWRDLEKAWQAPVRLVLSGGAADAIVRALTVPHTRHDTLVLTGLALIAHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y03</accession>
    <name>Q63Y03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metH2</name>
        <name evidence="5" type="ordered locus">BPSL0386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004204527.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107012.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0386"/>
    <dbReference type="EnsemblBacteria" id="CAH34374">
        <property type="protein sequence ID" value="CAH34374"/>
        <property type="gene ID" value="BPSL0386"/>
    </dbReference>
    <dbReference type="GeneID" id="56594298"/>
    <dbReference type="KEGG" id="bps:BPSL0386"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1281"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQEDYKM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="359" mass="38459" checksum="1013B7D60E53B797" modified="2004-10-25" version="1">MSEPTPIAPFASSAAPAAPYTRGAALPQLLRQRILILDGAMGTMIQRYKLDEAAYRGERFKDFPRDVKGNNELLSITQPRIIREIHDQYFAAGADIVETNTFGATAVAQADYGMEALVVEMNVASAALARESAAKYATPEKPRFVAGAIGPTPKTASISPDVNDPGARNVTFDELRDAYYQQAKALLDGGVDLFLVETIFDTLNAKAALFALDQLFDDTGERLPIMISGTVTDASGRILSGQTVEAFWNSLRHAKPLTFGLNCALGAALMRPYIAELAKLCDTYVSCYPNAGLPNPMSDTGFDETPDVTSGLLKEFAQAGLVNLAGGCCGTTPEHIAAIAKALAEVKPRRWPSQYSEAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y23</accession>
    <name>BIOF_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">8-amino-7-oxononanoate synthase</fullName>
            <shortName evidence="1">AONS</shortName>
            <ecNumber evidence="1">2.3.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-keto-8-amino-pelargonic acid synthase</fullName>
            <shortName evidence="1">7-KAP synthase</shortName>
            <shortName evidence="1">KAPA synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">8-amino-7-ketopelargonate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioF</name>
        <name type="ordered locus">BPSL0366</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189736.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106992.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Y23"/>
    <dbReference type="SMR" id="Q63Y23"/>
    <dbReference type="STRING" id="272560.BPSL0366"/>
    <dbReference type="EnsemblBacteria" id="CAH34354">
        <property type="protein sequence ID" value="CAH34354"/>
        <property type="gene ID" value="BPSL0366"/>
    </dbReference>
    <dbReference type="GeneID" id="56594628"/>
    <dbReference type="KEGG" id="bps:BPSL0366"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1304"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPYFRPI"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01693">
        <property type="entry name" value="BioF_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022834">
        <property type="entry name" value="AONS_Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000380943" description="8-amino-7-oxononanoate synthase">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01693"/>
        </source>
    </evidence>
    <sequence length="394" mass="40699" checksum="6F13182EA9D2A68D" modified="2004-10-25" version="1">MNPLATLEQGLADIDAQGLRRCRRVADTACGAHMTVDGRAIIGFASNDYLGLAAHPRLVEAFAEGARRYGSGSGGSHLLGGHSRAHATLEDELAAFSGGFSDAPRALYFSTGYMANLAALTALAGRGATIFSDALNHASLIDGARLSRANVQIYPHGDADALDARLRACDAPTKLIVSDTVFSMDGDVAPLARLVALAETHGAWLVVDDAHGFGVLGPQGRGALAAHGLRSPNLVYVGTLGKAAGVAGAFVVAHETVIEWLVQRARSYIFTTAAPPSVACAVSASLAVIASDEGDARRAHLGALIKRTRAILRATHWQPVDSHTAVQPLVIGSNEATLAAMAALDAQGLWVPAIRPPTVPAGTSRLRISLSAAHSFDDLARLEAALVTPIGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YA2</accession>
    <name>Q63YA2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197822.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106913.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0286"/>
    <dbReference type="EnsemblBacteria" id="CAH34274">
        <property type="protein sequence ID" value="CAH34274"/>
        <property type="gene ID" value="BPSL0286"/>
    </dbReference>
    <dbReference type="GeneID" id="56594363"/>
    <dbReference type="KEGG" id="bps:BPSL0286"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1418"/>
    <dbReference type="eggNOG" id="ENOG5031CZK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGYVMDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="112" mass="12491" checksum="1338FBC0D8F2C57C" modified="2004-10-25" version="1">MTAAKFFLRYTLVPFVAIVLVVVWAFNRESDEIDARQYAALVAAYPGFTPDLRDEVNRAMRDGKLAKSDYASIVRDSLNHGYVLDWSSTNVDLNAERGKLLGLVKSDAHAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YG8</accession>
    <name>Q63YG8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198965.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106847.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0218"/>
    <dbReference type="EnsemblBacteria" id="CAH34206">
        <property type="protein sequence ID" value="CAH34206"/>
        <property type="gene ID" value="BPSL0218"/>
    </dbReference>
    <dbReference type="GeneID" id="56594433"/>
    <dbReference type="KEGG" id="bps:BPSL0218"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1496"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYCVQPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="40"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="429" mass="44198" checksum="DADAC376658F4001" modified="2004-10-25" version="1">MTVPPGAPRPAAAGRANSAHAAQGASPVGAAPYLERGSRGYWHASVALLFAGYATFSLLYYVQPLLPEFSKAFGVSPAQSSLALSFATAALAAAVFVAGFVSEALSRHRLMTASLTASSLLTLAAAFAPHWHQLLILRALTGLALGGVPAVAMAYLAEEVHPDGLGLAMGLYVGGTAIGGMAGRVITGILTDLFSWRIAVGAIGVLGLASMLAFRMLLPPSRHFVPRRGLNLAHHRTSLAHHLRGQRELPVLFAMAFVLMGSFVTLYNYIGYRLLAPPYSMGQATIGAIFVVYLVGVVASPLSGRLADTLGRGRVLIASLAVMLGGVALTLLHPVAAIVAGVACVTFGFFAGHAVASGWVGRLAQHGKGQAAALYLLAYYLGSSVVGSLGGRFWSTLGWPGVAALVGALLALGVVAAAWLRARERGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS9</accession>
    <name>Q63YS9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535322.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106736.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0110"/>
    <dbReference type="EnsemblBacteria" id="CAH34094">
        <property type="protein sequence ID" value="CAH34094"/>
        <property type="gene ID" value="BPSL0110"/>
    </dbReference>
    <dbReference type="GeneID" id="56527604"/>
    <dbReference type="KEGG" id="bps:BPSL0110"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1619"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NAPYFCQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050126">
        <property type="term" value="F:N-carbamoylputrescine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017755">
        <property type="entry name" value="N-carbamoylputrescine_amidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03381">
        <property type="entry name" value="agmatine_aguB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="291" mass="32294" checksum="69D329ECDCFF6A8F" modified="2004-10-25" version="1">MRKTTVAVTQMACDWNVDANLSRAERLVRDAAARGAQIVLLQELFETPYFCIDQHPAHLALAQPYEGHPWLMRFASLARELGVVLPVSFFERAGQTQFNSVAIFDADGRALGIYRKTHIPDGPGYTEKYYFTPGDTGFRVWDTAYGRIGVGICWDQWFPECARAMALAGAELLLYPSAIGSEPHDASIDSRAHWRNAQRGHAAANLMPVAASNRVGVERGASGEIVFYGSSFIAGADGEMIVECDRHDEAIATAEFDLDALAYRRRGWGVFRDRRPECYRALSEGAADRVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-02" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YW4</accession>
    <name>RL34_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmH</name>
        <name type="ordered locus">BPSL0075.1</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198824.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106701.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YW4"/>
    <dbReference type="SMR" id="Q63YW4"/>
    <dbReference type="STRING" id="272560.BPSL0075a"/>
    <dbReference type="EnsemblBacteria" id="CAH34059">
        <property type="protein sequence ID" value="CAH34059"/>
        <property type="gene ID" value="BPSL0075a"/>
    </dbReference>
    <dbReference type="GeneID" id="60547760"/>
    <dbReference type="GeneID" id="62012619"/>
    <dbReference type="GeneID" id="64462770"/>
    <dbReference type="GeneID" id="67432765"/>
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    <dbReference type="PATRIC" id="fig|272560.51.peg.1659"/>
    <dbReference type="eggNOG" id="COG0230">
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000187359" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <sequence length="44" mass="5195" checksum="57BA3604DAEF4E65" modified="2004-10-25" version="1">MKRTYQPSVTRRKRTHGFRVRMKTAGGRKVINARRAKGRKRLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HU7</accession>
    <name>Q63HU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190247.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112325.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2323"/>
    <dbReference type="EnsemblBacteria" id="CAH39809">
        <property type="protein sequence ID" value="CAH39809"/>
        <property type="gene ID" value="BPSS2323"/>
    </dbReference>
    <dbReference type="GeneID" id="56598435"/>
    <dbReference type="KEGG" id="bps:BPSS2323"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5958"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYAWRDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011220">
        <property type="entry name" value="UCP028205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028205">
        <property type="entry name" value="UCP028205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266051" evidence="2">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="29262" checksum="8D891453E6FA58E9" modified="2004-10-25" version="1">MRRLFRQWWAGLSFCAAALAHAQTAPDPQVLLAQSDAIRTPAKSFVLTATLTEYRAGKQVDGNTLSIYSKPDAPGGAFRTLVRFVAPARDTGKLMLKNGNDLWFYDPANQASIRISPDQRLLGQAANGDVVTVNLAHDYRAALKGAEDVMDGDRQTRHCYKLSLTGNAPGLTYHRIEMWLDASNSRPVKAKFYSESDRLLKSAFYRRYTAELGVERPTETVIIDGLDPNWVTVMRFSGYAWRDIPDAWLQRDYLPRFQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HY0</accession>
    <name>Q63HY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112292.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2289"/>
    <dbReference type="EnsemblBacteria" id="CAH39775">
        <property type="protein sequence ID" value="CAH39775"/>
        <property type="gene ID" value="BPSS2289"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2289"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5910"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGYKVNF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266445" evidence="4">
        <location>
            <begin position="22"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="5">
        <location>
            <begin position="7"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="375" mass="38839" checksum="6C2172AB8F7A929D" modified="2004-10-25" version="1">MNAKSIAAAALAVAQAGLAHAQSSVTLYGALDAGVLWQNTSAASFSPTAPNTGAVVRFKDGGVYSSLWGIKGTEDLGGGYRVNFRLQGAFDGGTGKFGLSDAPGAVAAFNQIATLGVSGPFGTFNAGRQIVPMIYAMADTDVRAARFFGSVLTAWLGLNTAAGWPGNSTNAPIGALYDSDALVYQSPAFGGASLALEYAPGGVPGGVQRGARASIVLKYASNALNLAAVYYNGHDTNPAPGASATGLDNNRFVYVGAQYKLKDVAVSASYGNGRNPARGDRVNLDMFAFGLGYRVSPFFRVSSGVYYLKDRNRSANRSTSIVLGADYELSKHTTLYAQGGRVDNRGTMAQMLAYGQPVAPGLATTAAMLGMRHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HY9</accession>
    <name>Q63HY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DksA/TraR C4-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187469.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112283.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2280"/>
    <dbReference type="EnsemblBacteria" id="CAH39766">
        <property type="protein sequence ID" value="CAH39766"/>
        <property type="gene ID" value="BPSS2280"/>
    </dbReference>
    <dbReference type="GeneID" id="56598389"/>
    <dbReference type="KEGG" id="bps:BPSS2280"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5894"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MEDAMGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="131" mass="14439" checksum="9B45ABF157ABD4AC" modified="2004-10-25" version="1">MAAFDEHQLQVLGALLRACRQALQADVRAGERQRADEPYANLAGPAPDEGDEANADLFVDVDHALLGMKLAELRDVDAALQRIARRDYGCCADCGQPIAYERLLARPTALRCAPCQRAHERRFATQPRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ2</accession>
    <name>Q63HZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112280.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2277"/>
    <dbReference type="EnsemblBacteria" id="CAH39763">
        <property type="protein sequence ID" value="CAH39763"/>
        <property type="gene ID" value="BPSS2277"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2277"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6722"/>
    <dbReference type="OMA" id="MHQERRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="143" mass="16095" checksum="F1C79AF8B2A7D11B" modified="2004-10-25" version="1">MHQERRKRNADRHGTHPYDADSRAAPREAPRFEHEPKKQRDAAQHEVDRDRAAREIRERIEHKARPDVRRAERPISQDVAQTPIGAAGAISPSTAHSIFLEIGLALAGRPIQVRRNRAPFTHGTPRRRPARGPTARTASPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I03</accession>
    <name>Q63I03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187830.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112269.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2266"/>
    <dbReference type="EnsemblBacteria" id="CAH39752">
        <property type="protein sequence ID" value="CAH39752"/>
        <property type="gene ID" value="BPSS2266"/>
    </dbReference>
    <dbReference type="GeneID" id="56598374"/>
    <dbReference type="KEGG" id="bps:BPSS2266"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5872"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYWTCKE"/>
    <dbReference type="BRENDA" id="2.7.8.7">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="133"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="271" mass="29980" checksum="B7D8A6BC2AEE87D0" modified="2004-10-25" version="1">MTNASTTLPTTNASPVPPLGERDAHVWYARTAACDTPALRERYRALLSAEERERLGRFAFDHLKLEYLVTRALCRTVLSAYVDAVAPEQWRFRANAHGRPEIDAGDARPPLRFNLSNARSIVACVITRTADAGIDVEERARSNDLDGIAASHFSASERAAFFALPPDARRTRFFELWTLKEAYIKARGVGLSIDLGEFSFALPAQPVRIAFDRHVDDDASHWQFALLDVGAEHQMALGIRDPHAAARPFDITMREIVPEPAASARCAAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I11</accession>
    <name>Q63I11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523304.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112261.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2258"/>
    <dbReference type="EnsemblBacteria" id="CAH39744">
        <property type="protein sequence ID" value="CAH39744"/>
        <property type="gene ID" value="BPSS2258"/>
    </dbReference>
    <dbReference type="GeneID" id="56598366"/>
    <dbReference type="KEGG" id="bps:BPSS2258"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6694"/>
    <dbReference type="eggNOG" id="ENOG5031DUE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AILYEHS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="17563" checksum="6152CA11FA5E772F" modified="2004-10-25" version="1">MPTNERGGSAFADRQAAVAAVELLLPAFSAALQSDFVGDSGCLHIVVMDPALGPSLASFDDAILYEFSLPDPQYWDADYRAYARAKARLSWETGRDGHLLQANEPHRLRAGDTTLWGSVALDGIVVGVSGAQPWFDEAFAGCIAHCLRAIAKHRAHATPDTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I47</accession>
    <name>Q63I47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MipA/OmpV family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552253.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112225.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2223"/>
    <dbReference type="DNASU" id="3095997"/>
    <dbReference type="EnsemblBacteria" id="CAH39708">
        <property type="protein sequence ID" value="CAH39708"/>
        <property type="gene ID" value="BPSS2223"/>
    </dbReference>
    <dbReference type="GeneID" id="56531688"/>
    <dbReference type="KEGG" id="bps:BPSS2223"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5813"/>
    <dbReference type="eggNOG" id="COG3713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LGEWQYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010583">
        <property type="entry name" value="MipA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38776">
        <property type="entry name" value="PTHR38776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06629">
        <property type="entry name" value="MipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267208" evidence="5">
        <location>
            <begin position="29"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="30676" checksum="FB863045982CBD05" modified="2004-10-25" version="1">MRDAAARRRTARGIVCAACAAAAVSAHAQTPSPLGEWQYSAGVPLDKLFNPNPQTWQISVGAAATLQPRYDGSNQYRPMAGPTFDARYRDLWFVSTGEGIGVNVLRGPNWRATLSAGYDLGRREADDRGHLTGIGNINPAAVIKLSADYVISHAFPLVLRADVRRSVGGANGWVADLAAYMPLPGSSETFYWFAGPTVTFADSRYMNSWFGVNDAQAARSGHPRYAPSAGVKSFGGGMTLVWFVTKHWFVTADGAIEQLVGSAARSPLTQRSTNAVVDVSINYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I68</accession>
    <name>Q63I68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative porin related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529415.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112204.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2202"/>
    <dbReference type="EnsemblBacteria" id="CAH39687">
        <property type="protein sequence ID" value="CAH39687"/>
        <property type="gene ID" value="BPSS2202"/>
    </dbReference>
    <dbReference type="GeneID" id="56531709"/>
    <dbReference type="KEGG" id="bps:BPSS2202"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5787"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NAWPFFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266056" evidence="4">
        <location>
            <begin position="24"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="5">
        <location>
            <begin position="15"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="357" mass="37389" checksum="1966C5FA8BA57B87" modified="2004-10-25" version="1">MNRLGATTWPIAIGLALAGPAFAQSSVALYGIVDQSVRYTTHASAANDSAVQMANGAITNSRWGMKGAEDLGDGLKAIFRLENGFEPQSGQADGARLFGRYAYVGLSGRLGTVELGRQTTEGFNLFGDLDPLTIGNYTANMWPYFLTQGYANNVVSYANTLGGLAVGASYGLGGVAGAMSRNAYWGVRSAYTHGALTVGAVYQQTRDADGRAQQMWGAAGRYAVGPATLFAGYLGGKDATGAIDRDYLNAPGRTVAYGSFADHPRYDAIGYAGVAYRVDPALMLTGAFYYDAIRNVNGVGGNGGKRRAGVLEAEYALSKATQLYASADYNQVCGGAATEMPGRGNQTGVALGLRHMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I72</accession>
    <name>Q63I72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523363.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112200.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2198"/>
    <dbReference type="EnsemblBacteria" id="CAH39683">
        <property type="protein sequence ID" value="CAH39683"/>
        <property type="gene ID" value="BPSS2198"/>
    </dbReference>
    <dbReference type="GeneID" id="56531713"/>
    <dbReference type="KEGG" id="bps:BPSS2198"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5781"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIKRAWP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="173"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="34251" checksum="DA75BCC4FD086E31" modified="2004-10-25" version="1">MENLNVMHILLLLGLFAIVVAGVMATWLAFAPRGLARRLEQIGGAGAVAAGDGRAPPAVWIEKLAEISQPISKLSLPKSGWENSPLRLRLINAGWRSPGAAHLYFAAKTVLALALPAAAMPLLIGTAIADSPYSVSAMLVLIGAFGFYLPNAMLARRIAARQRMIVEDFPDALDLLTVCVEAGLGLDAALTKVADELRLRSPVVADELGLMLLEMRSGFTKETALRNLALRTGAEDVDAFSTMLIQADRFGTSIGASLRVLSDTLRTQRRMRAEERAAKIALKLLFPLIFCIFPALLTVLLGPAFIHIYRTLLPTMAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IK5</accession>
    <name>Q63IK5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112067.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63IK5"/>
    <dbReference type="STRING" id="272560.BPSS2064"/>
    <dbReference type="EnsemblBacteria" id="CAH39544">
        <property type="protein sequence ID" value="CAH39544"/>
        <property type="gene ID" value="BPSS2064"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2064"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6459"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYTGIVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266472" evidence="4">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="5">
        <location>
            <begin position="10"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="359" mass="38204" checksum="7A896782AF38917E" modified="2004-10-25" version="1">MQMKKVMLATWLLAIGGFAQAQSSVTLYGRIDTGLEYMSGLTNGSGRSVSRLRAESGDWGTGMFGLKGVEDIGGGTKVIFQLEGGLNSMVGQVGSGTTIFNRWAYVGVQNDTYGTLTAGRMLWISNGLWDFDPLGQTAWSSASLVRGRNWQASSNNIAYQSPKWGGFDVAGQYALSNSTNWNAGGANGQGRSVGLQATYTSAFFQVRGIYDELRNPTTGQFDDVFNYSREYFGGLNVFLGPFKLQAAYQASQASQAPAGAPTRTQLEWGGLAWQATPAVALIGAVYHVNANNGGGNATIYTIAGSYNLSKRTLLNVQVATARNSRNANFSLEANGPTSSDNPLPGHSQSGIYAGIQHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IK6</accession>
    <name>Q63IK6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS2063a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112066.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2063a"/>
    <dbReference type="EnsemblBacteria" id="CAH39543">
        <property type="protein sequence ID" value="CAH39543"/>
        <property type="gene ID" value="BPSS2063a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2063a"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="61" mass="6691" checksum="92034A86300010E4" modified="2004-10-25" version="1">MSGRLEIPMESFARAVEIVLKDSELKDAPGYCPEPALWTHAVHQCGYIQSRHATGHVLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IK7</accession>
    <name>Q63IK7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112065.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2063"/>
    <dbReference type="DNASU" id="3095915"/>
    <dbReference type="EnsemblBacteria" id="CAH39542">
        <property type="protein sequence ID" value="CAH39542"/>
        <property type="gene ID" value="BPSS2063"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2063"/>
    <dbReference type="eggNOG" id="COG3316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IDHEQEN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="2">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="200" mass="22477" checksum="7F86643BF2A7E31F" modified="2004-10-25" version="1">MLPSAPCSGWSHHTLKPLGAGTRGTGYIMPVTNMIHLDNRDHADRQSHGQPAHVLMLEQSPGVVPKSLLGKGLTYLREQWPKLIRYVENGSWPISNNPCENAIRLFCVGRRGWLFSDTVDGANACANLYTLVETSKTNGIDLYRYLAWLFRRLPLAKTVDDYDALLPWRMPVDIHVDPFDKERSTIDHEQENHSAGSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IL1</accession>
    <name>Q63IL1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524853.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112061.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2059"/>
    <dbReference type="EnsemblBacteria" id="CAH39537">
        <property type="protein sequence ID" value="CAH39537"/>
        <property type="gene ID" value="BPSS2059"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2059"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5603"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PELHHGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="136" mass="14299" checksum="382F4D1E44C123D6" modified="2004-10-25" version="1">MSIQAQTSAITCANAPDIPPPAGHYSHVCVANGFVFVSGQLPIDPTGKPLSDAPFDAQAKQVLHNVDATLKAAGVTRDDLVQVRVFVSDIEHWPIFNGLYAEWIGAHKPARAVAESASLHYGSAVEVEAIALASAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IP8</accession>
    <name>Q63IP8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2017" name="J. Lipid Res." volume="58" first="137" last="150">
            <title>Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei.</title>
            <authorList>
                <person name="McLean C.J."/>
                <person name="Marles-Wright J."/>
                <person name="Custodio R."/>
                <person name="Lowther J."/>
                <person name="Kennedy A.J."/>
                <person name="Pollock J."/>
                <person name="Clarke D.J."/>
                <person name="Brown A.R."/>
                <person name="Campopiano D.J."/>
            </authorList>
            <dbReference type="PubMed" id="27784725"/>
            <dbReference type="DOI" id="10.1194/jlr.M071258"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 21-493</scope>
        <scope>PYRIDOXAL PHOSPHATE AT LYS-291</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112024.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="5K1R">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=21-493"/>
    </dbReference>
    <dbReference type="PDBsum" id="5K1R"/>
    <dbReference type="SMR" id="Q63IP8"/>
    <dbReference type="STRING" id="272560.BPSS2021"/>
    <dbReference type="EnsemblBacteria" id="CAH39499">
        <property type="protein sequence ID" value="CAH39499"/>
        <property type="gene ID" value="BPSS2021"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2021"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6407"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="BRENDA" id="4.1.2.27">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:6885"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5K1R"/>
        </source>
    </evidence>
    <sequence length="493" mass="54285" checksum="8529F66A0B470D2C" modified="2004-10-25" version="1">MRSIAARSSHAGAGLEQEGVMDLEEGVRQLYPYAAEFGALHEFPERGMPRERLLEELRSMAVREDRKWESGRCSGTMYCGDHEHYAFLNEAYGLFSHVNALQRDLCPSMNRMESEIVAMTVALLHGEAVQRHDGAHRACGALSLGGTESILNATLAYREKARAERGIERPRMIWPASAHPAFRKAAHLFGFDVTVAPIDPVTMQVDADFVRDAVDANTVMLVGSACNYPYGTIDPIGALSAIAVEKDVWLHVDGCLGGWMLPWGEALGYPDIPAFDFRLPGVTSISADTHKFGYGPKGGSVLAWRDASFRRHQYFLMTDWVGGVYGSPGLTGSRSGGLIAATWAALRSLGREGYLARAKAIFETAFDMQAAVRAIPELRVLGKPTFCFAFTSDAFDIYHVNDFMRQRGWRFNGLQHPDALHMCVTGPQTQPGVAERFRQDLGEAVEHARHRAHARPQSSGVYGGDAAGLDLRDDARARAFFTQVLDLFTDCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IR7</accession>
    <name>Q63IR7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530212.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112005.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1999"/>
    <dbReference type="EnsemblBacteria" id="CAH39477">
        <property type="protein sequence ID" value="CAH39477"/>
        <property type="gene ID" value="BPSS1999"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1999"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5513"/>
    <dbReference type="eggNOG" id="COG0672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYGTLLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="28713" checksum="ED0A3A042821ADF7" modified="2004-10-25" version="1">MLSTAVIVFREVLEAALVVSIVLAATKGVPGRAWWVSAGLLGGVVGAAFIAAFADVVSAWASGMGQEVFNAGVMFVATIMLAWHSIWMGKHGREMAQQLSQVGRAVAAGSRPLTGLAIVVGVAVLREGSEAVLFLYGIAAGDPRQAPQMIAGGALGVLGGVGLGAGMYAGLLQIPLQRLFSVTNALIVLLAAGMASQGTGFLVSAGWLPSWGDTVWDTSWLLKESSVVGKMLHTLVGYTARPAGIQIVAYVATLLVIVLLARRVARKQAIVARPTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J72</accession>
    <name>Q63J72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190665.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111850.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1846"/>
    <dbReference type="EnsemblBacteria" id="CAH39322">
        <property type="protein sequence ID" value="CAH39322"/>
        <property type="gene ID" value="BPSS1846"/>
    </dbReference>
    <dbReference type="GeneID" id="56598251"/>
    <dbReference type="KEGG" id="bps:BPSS1846"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5297"/>
    <dbReference type="eggNOG" id="COG4575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EKPWQGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043605">
        <property type="entry name" value="DUF883_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043604">
        <property type="entry name" value="DUF883_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05957">
        <property type="entry name" value="DUF883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19029">
        <property type="entry name" value="DUF883_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF883" evidence="1">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883_C" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="126" mass="14063" checksum="0D2693020AD238E4" modified="2004-10-25" version="1">MALSDTVEYKLDRGLSEARRAGRRFARDARSAARDLNGDVKDNMRSLVDELDALLKEDVDVDALRKRLHGRLEAARDTLDDASWHASRRLRQSAERVTQAVHDNPWQTAGIVAGLAFAAGILLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JB7</accession>
    <name>Q63JB7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical transposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111805.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1801"/>
    <dbReference type="EnsemblBacteria" id="CAH39277">
        <property type="protein sequence ID" value="CAH39277"/>
        <property type="gene ID" value="BPSS1801"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1801"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6123"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHDAGTE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="2">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="145" mass="16241" checksum="9335184C4B288759" modified="2004-10-25" version="1">MSFSTGRTQMDTKHDGGSPIAERRTEGFRLLESGMPQADVARRLVVSRQSVCRWAKRLAERDGRISKAPGRPRRLNSAQCATLRAMLDDGALAAGFASPQWTLARVRKLIEREFGVAYSKTGGWELLRTLGVSLQRTERHPYIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JC1</accession>
    <name>Q63JC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative trehalose trehalohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190582.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111801.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1797"/>
    <dbReference type="EnsemblBacteria" id="CAH39273">
        <property type="protein sequence ID" value="CAH39273"/>
        <property type="gene ID" value="BPSS1797"/>
    </dbReference>
    <dbReference type="GeneID" id="56598229"/>
    <dbReference type="KEGG" id="bps:BPSS1797"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5238"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SERHPVH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM_48" evidence="3">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3459" evidence="4">
        <location>
            <begin position="423"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="547" mass="59511" checksum="51C21C103CE884B8" modified="2004-10-25" version="1">MSECPHDPYAQHHSHCLPFGAQPCGAAGATTRTHFRVWAPAHAAVTLALDTAGGLHELPMAPAGDGWFETFADCGAHTRYRYRLDEALTIPDPASRSQPEGADGPSEVIDPRAFTWRHTFWRGRPWEEIALYAIQPGAAGGYDGVRERLPQLAQLGVTALELLAAPQARDDSLPFAPIAAYGGVDALKRLIDEAHGFGLAVLLDLDYARFGCGSDEMRRYAQPFFHTRDDPLQAPPLALDHPQVCDFFCDNALYWLEEYRCDGLRIREADRIDSAWLREIADRVHAAMPTDRIVHLVLGSERHPSHLADTHFDAQWNGCGERALYRLTGRRDRAHDDGVSTHQSIHALARALTANGAVFQRAHPAGEGGMADVGLPLTSLVLSDGVVRDAREADLAALALSLLTPQIPLIFDEAAGDASRRHFVQSALAVRAKLIAPRLIDVRPRRADMLRAADGVEADALVAAWRLGDGETLSIALNLSPQALPFHGAPDGTIVFETPARARDRVDAGVLPPYALVAWLTGDVNQYALTHDVRRYADVAPHSPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH8</accession>
    <name>Q63JH8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CAH39213">
        <property type="protein sequence ID" value="CAH39213"/>
        <property type="gene ID" value="BPSS1738"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1738"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5164"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50331"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="39980" checksum="93A05918D83522E0" modified="2004-10-25" version="1">MNTDDAIVSFRGVRKTYDGETLVVKALDLDIRRGEFLTLLGPSGSGKTTCLMMLAGFEFPTGGEIRLDGELLNNVPPHKRNIGMVFQNYALFPHLSVEQNVDYPLNVRRMPAAERAARVAAALAMVQMERFAKRYPAQLSGGQQQRIALARALVFEPKLVLMDEPLGALDKQLREHMQYELKALHEKLGLTFVYVTHDQGEALTMSDRVAVFDKGIVQQLDTVDRLYESPCNEFVANFIGDSNRLRGTVASVHGEFCEFRLEDGTRLVGLNAGNAQAGASGVACIRPERMSVAPGSGRAANGAANALAGEARSLIYFGDHVRMRCALPGQDECFVKVPLGTGALDAFAPGVPISLEFQPEHLRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JR4</accession>
    <name>Q63JR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative patatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530370.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111658.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1652"/>
    <dbReference type="EnsemblBacteria" id="CAH39126">
        <property type="protein sequence ID" value="CAH39126"/>
        <property type="gene ID" value="BPSS1652"/>
    </dbReference>
    <dbReference type="GeneID" id="56529936"/>
    <dbReference type="KEGG" id="bps:BPSS1652"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5045"/>
    <dbReference type="eggNOG" id="COG3621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WANNPVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35376" checksum="10C89B6AF6D7DC08" modified="2004-10-25" version="1">MAFKILSCDGGGIRGLITALLIQDLDRRSGILAKADGFAGTSTGGLIALALARGVSISEVVDVYRNRGSEIFQESGAWLEQRATIATDASFAAFAGPGLFACQYVNTGLKRIAQELLRGGDLTELHRLTVINSSRLWDPALRSWSACTFSNASGNAYRHVALVDAALATSAAPSYFPPYEVPSLGYFADGGLFANNPSMTAVSEALASRLGGELGNLRVLSFGTGISQAGIRPSAIGDPLRWGVTTWFWPFESHDVPASALLGLTLDTTAMLATQQATQLLGGGYRRANFVLGETVGLDDWRKASLLESETAAYMKTPAWEGVCQWVDANWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K07</accession>
    <name>Q63K07_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187240.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111565.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1559"/>
    <dbReference type="EnsemblBacteria" id="CAH39032">
        <property type="protein sequence ID" value="CAH39032"/>
        <property type="gene ID" value="BPSS1559"/>
    </dbReference>
    <dbReference type="GeneID" id="56597905"/>
    <dbReference type="KEGG" id="bps:BPSS1559"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4923"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEAFWWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="31704" checksum="210F7454D2F6F96B" modified="2004-10-25" version="1">MATPTLKQLDAFYWAATCANFSTAAQRLHLSISSLSKRINELEQAVGRTLFDRSGHRAVLTEDGVALLPAAVRVLESVAALQDAFAGEKGLSGRLRFGVGELSALTWLARFVAAVQTLHPQLSLEPYVDVGAALEEKVDAGELDFAVIAGRSSRGSILSQPVAEARFAWMAAEKLVGGERALTPGLLARHALVILPSGSGVTRILDEWLLACGINHPRRIACNHWSAVAGMLREGVGIGFLPADWADARAGGGLVQLTSEPPLSPLHYAFQWRRGDMRGLIPSMLALVRQHADFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K21</accession>
    <name>Q63K21_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 3 secretion system secretin</fullName>
            <shortName evidence="2">T3SS secretin</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bsaO</name>
        <name evidence="2" type="synonym">sctC</name>
        <name evidence="6" type="ordered locus">BPSS1545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family. T3SS SctC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205639.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111551.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1545"/>
    <dbReference type="EnsemblBacteria" id="CAH39018">
        <property type="protein sequence ID" value="CAH39018"/>
        <property type="gene ID" value="BPSS1545"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1545"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4900"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VWYDDGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02219">
        <property type="entry name" value="Type_III_secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003522">
        <property type="entry name" value="T3SS_OM_pore_YscC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01337">
        <property type="entry name" value="TYPE3OMGPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02516">
        <property type="entry name" value="type_III_yscC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026403892" description="Type 3 secretion system secretin" evidence="2">
        <location>
            <begin position="27"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="5">
        <location>
            <begin position="210"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="620" mass="66137" checksum="8F447ED7B2093795" modified="2004-10-25" version="1" precursor="true">MMYADTARRYAAALAASLLMTGAAFAAPTDAAPLADAPAAASATPDARDGDASRVAAPQDDERHFVANDASISVLLNALSGRLHKPIVASEKVRRKHVTGEFDLAQPRALLARLGESMSLLWYDDGASIYIYDNSEIKNAVVSMRHATVRNLRDFIRQTRLYDPRFPVRGDDLSNTFYVTGAPVYVNLVAAAARYLDEVRSNEASDRQVVRVVQLHNSFVVDRQYTLRDKEVDIPGMATVLGRIFGPARPGAPADSPVAAADATARGGAGGAAGKPAFSLADALPAPLDAGNAPGGAGSTHSTNPANAASPMGGAAGGVALPASDGVRAVAYPDTNSVILVGRLDKVQDMEALIRSLDVEKRQIELSLWIIDIRKSRLDQLGIDWQGALNAPGIGVGFNNRGGNVTTLDGTRFLASVAALSQTGDATVISRPIVLTQENVPATFDSNQTFYAKLIGERTVQLDHVTYGTLVNVLPRLTRDGSQVEMIVDIEDGNTDGATSDGQIVIDNNTMPLVNRTEINTVARVPHEMSLLIGGNTRDDVTRRTFRIPGLASIPLIGGLFRGHSDRHEQVVRVFLIQPKLLRAGAAWPDGQPWESGDPADNATLRATVQMLKPYMDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K63</accession>
    <name>Q63K63_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Clp-type ATPase chaperone protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205629.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111509.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K63"/>
    <dbReference type="STRING" id="272560.BPSS1502"/>
    <dbReference type="EnsemblBacteria" id="CAH38975">
        <property type="protein sequence ID" value="CAH38975"/>
        <property type="gene ID" value="BPSS1502"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1502"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4849"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEDFTAK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017729">
        <property type="entry name" value="ATPase_T6SS_ClpV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03345">
        <property type="entry name" value="VI_ClpV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="954"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1012" mass="106784" checksum="9995F6E24B5C53CF" modified="2004-10-25" version="1">MLLVDLKPLIEQLNPYCRNALESAVGACVARRHDDVAVEHLLARLCDEPSADVALLLRACGADAARLRRQADAALDARPAGDGGRPAFAPSLLALLQDAWLIASLELGDTHIRSAAVLAAAVARAARQPSPGGDDVLQSLRKDALVARFASGACARSIESRASGALDAAPGEASDTRDASSAIARYCEDFTAKARAGGIDPVFGRDAEIRQIVDILARRRKNNPVCVGEPGVGKTAVVEGLALRIAEGDVPATLRGATLLGLDLGMLQAGASVKGEFEQRLKRVIAEIRASQTPVVLFIDEAHTLIGAGGAAGASDAANLLKPALARGELRTIAATTWSEYKKYFEKDAALARRFQPVKLDSPNVATSVMILRGLKERYQDAHGVTIRDDALVAAAELSARYITGRQLPDKAIDLLDTACARVKVRQQTKPAALEDAQRAIQALERERRALRDELAERCAPDTPRVADIDRELAALSARAGALRDAWAAQRDAAQALVDARRACRAAADATDAAGTTGTAHAGELADSADVSDIADVAKMADAADAAPADAETGSNARDADVRMPAGTCARIAPNPDARARPPLRAPHADARERAARALAEATRRFEHAQRDTPLVRIDVDPDAIADVVADWTGIAAGKLRRDRANVMLRLADTLRRRIRGQDHAIEQISEAVKAGAAGVHDPRRPLGVFLLAGPSGTGKTETALAVADALFGDERSIVVVNMSEFQERHDVSRLIGSPPGYVGYGEGGMLTEAVRQRPYSVVLLDEVEKAHPDVLNLFYQVFDKGSLSDGEGKEVDFANTVIFLTSNLGADIIADIAARGARPDPDAMRAAVRPALSRHFKPALLARMTEIPYAPLAPDTLADIARLKLERIAARVAAQHATRIVYDDAVVAHVAARCTEVESGARNVDFILQRHVLPALAQHVLVCAGNAAPMPAIRVAIDAGGRFVVSNDAPADSDARDRSDASDASDASDAIDAVDAVDAVDAPNAPNAPNAPNAPNAPNAPNAPNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K70</accession>
    <name>Q63K70_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205628.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111502.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1495"/>
    <dbReference type="EnsemblBacteria" id="CAH38968">
        <property type="protein sequence ID" value="CAH38968"/>
        <property type="gene ID" value="BPSS1495"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1495"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4841"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRWCAFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="344"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="614" mass="64370" checksum="DAC89427689DC93B" modified="2004-10-25" version="1">MHGNSIDAGPPARARPARITRTARAAPRRADRAFAPGGALNAAGLLLLLFYANHLLSRPGACTSLNHTLSAVVWPAPVLGIALLLHCRRPLAWWLGAGSLFATLLAAGSLDWVPWHVDALFAAVNVVEAIAGAWLARRYLIAGGGVDTLRGFAMFVLLLPLGMAAMHATLAAAILSVWMNDREWLSEWSRAYAANALALLVLLPALLTWNARACGATWSRSRNQLPVLATFGSLCFASIWGYQAEVARALLALSLSWAALEGGLVLASQLNALSAIALIAMTLGGRGPYAWHHDGHGVWALQVDLIGVAILSMCIAIATGERRRLARQIERSRRFESLGFFAGGIVHDFSNVLTTIDCHAEYASERLASGARADDSIDEIHRAVERGRDLAAQILLAARRGEPVLTRVSVDEVVDEALAATRAAAWRGVEIVRCGDGARDGARRGDVRHVVFADRSQLARAVMNLVGNAVRAARATVVVRVGVNGGVNGGASDGASRGANDGGAPAARAFDVAIGEASMPGGVWIEVSDDGEGIDVEPLDRIFEPFYSNRSGAPGTGLGLAIVAGAALAHRGQIAVATDRGVGSCFRFTLPAAWGTGAPGAMDAGAPGAVQERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KL3</accession>
    <name>Q63KL3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0540</name>
        <name evidence="5" type="ordered locus">BPSS1348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528656.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110561.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111358.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0540"/>
    <dbReference type="EnsemblBacteria" id="CAH37997">
        <property type="protein sequence ID" value="CAH37997"/>
        <property type="gene ID" value="BPSS0540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38819">
        <property type="protein sequence ID" value="CAH38819"/>
        <property type="gene ID" value="BPSS1348"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0540"/>
    <dbReference type="KEGG" id="bps:BPSS1348"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4651"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DQFYGPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="527" mass="55572" checksum="30E282252F219344" modified="2004-10-25" version="1">MTQTATHAATRTTTLPVRRPARRLAALALAWALAGCVPSGLKPTLAPRTPGDDALAHTTGGATHGAWPSPDWVRQLGDPQLDALVDEALRQNPTLQAAQARIGVAQSQLQQFESLTGLTATAGASLSKAHVPRSGGTLNTTLNGLPVSVPLVGESVVSSSSLFVGLNYQLDLWGKNAAATRGLLSMRDAARVEAEQARLTLSVAIVTLYGELDRAYALRELLQQKRRASEQVEAVLRERAARGIDNGYDADDAALKRGKLLEQIALTDEQIQLQKLQLGVLSGRGPERGLSLARPKLAPLADAPLPARLPAGLLGRRPDIVAARLRVEAAYAAIDGTRASFYPDVNLAALGGLFALTPASLFRHDALGGSIGPALSLPIFDRSRLKAKLGGDVANADMALALYNQTVDAALGEVARQLTSLATLDTLLKAQQQALRAAQRMVALAQDRHRRGMGMRKDIDVAQLTLLDERAHVVELQARRRTLRVGLIGALGGGFDARPASGAPPAQAGQPFAAASRPVAAHDAQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KN3</accession>
    <name>Q63KN3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184412.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111338.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1328"/>
    <dbReference type="EnsemblBacteria" id="CAH38799">
        <property type="protein sequence ID" value="CAH38799"/>
        <property type="gene ID" value="BPSS1328"/>
    </dbReference>
    <dbReference type="GeneID" id="56597531"/>
    <dbReference type="KEGG" id="bps:BPSS1328"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4625"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRFFRFE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="27392" checksum="41A06991F08BADAF" modified="2004-10-25" version="1">MHATDDRLPRYQRLRDELAALIAARHWRPGEAIPTEQALAKRYDVAIGTVRKAVDLLVADGMLERFQGRGTFVRRASFDSSLFRFFRFQGRHGERRIPESRILRREVVEAPSAVAAALQIPARASVIEMTRVRLIDGAPMLAEEIWLPYDRFAAFARLELASIGDLLYPVYEAHCNQIVASATETLTVEAIGPVHARLLRIEPGTPAVVIERLAYGYDRRPLEWRRSRGPASEFIYQAEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KN8</accession>
    <name>Q63KN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536666.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111333.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38794">
        <property type="protein sequence ID" value="CAH38794"/>
        <property type="gene ID" value="BPSS1323"/>
    </dbReference>
    <dbReference type="GeneID" id="56530257"/>
    <dbReference type="KEGG" id="bps:BPSS1323"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4620"/>
    <dbReference type="OMA" id="ATMESAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="34144" checksum="AC4DBAE1D29A75D7" modified="2004-10-25" version="1">MDISKIQHSAVALDASSDSSSGQQASGHTAARQTSSRGAGAALGGLKELQDLKRGDLIMEHGNMHAVMYAGGDKPLVHSTNGKFFGVLQQGPNYLTKKFGNEAPTKLPVYRMKNADSPIPSEAARIGEQWAIRSGDTETTKTKTPFGENRLNDADEDKAVEWSPEATFRAARAALRSDEGMPLSKQQGVSCSQFVTYAYQAAALKKGGDASGGAHEALDSVKQAGAHRQGAFKTAENKVQQQAGLVQGAHEQATQAMPHTLQVNAKHMTADVLAERLRERGGDFERVGYAVPYEKDGESGVKLLPKDDPRATQKISNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KU1</accession>
    <name>Q63KU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205581.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111280.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1273"/>
    <dbReference type="EnsemblBacteria" id="CAH38740">
        <property type="protein sequence ID" value="CAH38740"/>
        <property type="gene ID" value="BPSS1273"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1273"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4543"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFAASCC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="5">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="586" mass="64158" checksum="9062AF4454D99E68" modified="2004-10-25" version="1">MSLNHAPFALASAFDRYLGDPSMPDNAFSYARCAQLDAHERFPDAVCAMLSQWGLHRYYVPERFGGMLRDFEQPLQLIRMLARRDLTVAIGHGKTFLGAVCVWVGATHEQASRFARRIGDGAIVSWGLTEREHGSDLLRSDTYAEADGDEYRIAGEKWLINNATRGDMISLLARTRREGGPRGFDMLLVDKHALSQGRLRPLPKERTHGIRGADISGIAFDDARIPASARIGVRGAGLETVLKGLQLTRTLCASLSLGAGDHALRLALGFACERRLYGRTLIDLPNARRTLIDAYTDQLLAEAAALVGARSIQALPDEMSVTSAVVKYLVPTRAEAMLDTLAELLGARAFLADTYAHGMFQKVQRDNRIVSLFDGNTLVNLNAIVNAFQTLAKRYRGRDGADAGQALAAFDLGMPLPAFDRGALSLVSRHGCRVVGALPALADGIAQRAACEPALSRLVVPVRRLAALTDDVHRRMLACPPVRVHVPVEQFELAKRYALCHAAASALGLWWHTRHRVGEASAAPPWRDGLWLRAVLRRVRVALGDAADFDDEAGDALWRALLRQHRDGLLFSLLPCELAEHRGEAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KV4</accession>
    <name>DTML_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>Dictomallein</fullName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dtmL</name>
        <name type="ordered locus">BPSS1260</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dictomallein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH38727" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38727.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547545.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111267.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63KV4"/>
    <dbReference type="SMR" id="Q63KV4"/>
    <dbReference type="STRING" id="272560.BPSS1260"/>
    <dbReference type="EnsemblBacteria" id="CAH38727">
        <property type="protein sequence ID" value="CAH38727"/>
        <property type="gene ID" value="BPSS1260"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1260"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5453"/>
    <dbReference type="eggNOG" id="ENOG502Z8SD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WWTPTVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019503">
        <property type="entry name" value="Peptidase_M66_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51694">
        <property type="entry name" value="PEPTIDASE_M66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000322655" description="Dictomallein">
        <location>
            <begin position="1"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M66">
        <location>
            <begin position="233"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="687" mass="71335" checksum="E62E11A4DA83B233" modified="2008-03-18" version="2">MGNGERPPARRPDSSGSPPPAADAPAASNHPFSSHDTKHMTSRRLASRTAVAASLSALMLAACGGDDSANAPTAGGAAPLTPAVASPAGPTGSTPGSTPGATTAPAPSSTSAGQLSVDKMAFAQTHVVPSGGLSWTLPNASASLRPISRRDALVLVAIGQADAVQPVLEAWKDGAKLGALALSPPSALPPTESGGRAYANDRWSAVVPAAWMVPGVSFSVSASNYTSSVAQAPVFGTDADVQLTILPFYLFGADDTNSPPLSTTQAPDAATQQEIFAKWPTAELKVRTHPAGRFSLATVVVGPRADRTGAAQPAYPVTALDQQKDGYGVMSAMLTLITNMRTANGDGPLNNQYYAPLIALNSNGQFANLGGGLGGVGSGAAVGDHRYTGIFIHEQGHAFGLNHAGDEYAKGAYPYAGGSLSGSVWGYDPNHREFLDVLVPTTASSYAKCASSHQLDAQGRCYKQDPMQGGAGDQSSGYKFATFSDYNTGRMQAWIASRVLADPASSTGYSKWDSAAQARAPYTPTTDNNGLYGVNQNLPVQAGVPVHTIVVSFSKAGSAGASYIYPPFSYTGNLIATFDPTSAADRQAITVDKGTYPWYCKGTGCDYTLRVTYADGSRTYRVLQGGFRAWWTPTVDDANATNPLSGSSFRVWAINVPGDKRIGKIELLDTPMVWNGMPANPTVLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KX6</accession>
    <name>Q63KX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AraC family transcriptional activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940453.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111245.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1237"/>
    <dbReference type="EnsemblBacteria" id="CAH38704">
        <property type="protein sequence ID" value="CAH38704"/>
        <property type="gene ID" value="BPSS1237"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1237"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5414"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGIEFRC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="37242" checksum="95937B72051A3462" modified="2004-10-25" version="1">MNGGRPSVHAQERQMNPDLEIVPTRRDESFRAWSHDYPHTVAKWHFHPEYEIHLIQGSRGKFFVGDHIGDFAPGNLVVTGPNLPHNWISELGPGERVPSRDVVLQFSRDAAEKMVAAFAELQPVLDLIDEASRGVQFPDEIGLAVAPLMLELASAHGCRRVEVLMALFDRLASCAARRTLAGPGYRIDAQHYMSSTINQVLAYLRQNLPGALREADVAEFAGMSVSTFTRFFRRHTGSTFVQYLNRLRINEACELLMCSALSVTDICYRIGFNNLSNFNRQFLAMKGMPPSRFRALHRLNEPHDAPEPHEPHASLAPATARAVIHSHRSLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KY5</accession>
    <name>Q63KY5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202565.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111236.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63KY5"/>
    <dbReference type="STRING" id="272560.BPSS1228"/>
    <dbReference type="EnsemblBacteria" id="CAH38695">
        <property type="protein sequence ID" value="CAH38695"/>
        <property type="gene ID" value="BPSS1228"/>
    </dbReference>
    <dbReference type="GeneID" id="56597447"/>
    <dbReference type="KEGG" id="bps:BPSS1228"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4474"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFVWAYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="38581" checksum="1F0BF1238404E56D" modified="2004-10-25" version="1">MKPEMIIQTYGADTSGMVCGFRFAPDSAGEPVDAGVAAEWAAGRGARPDEFLWLHFNLAHGASERWMRAHLDLPETFHEFLREGSHSTRIEQQDGVLRAVVNDVMFSLDLEASEIATMWAYVDRRMMVTARAKPLRSIDTLRESVRQGERFRSPAELLIHLLRDQADLMMHIVRRASTDVDRIEDRFLSERLSANRGQLSAMRRTLTRLQRMLAPEPGSIFRLLAKPPAWLLSADVQELRESTEEFSVVLADLAGLIERIKLLQEEIASRLDEQNNRTLFTLTLVTVIALPINIVAGFFGMNVGGIPFSENKHGFWMMVLLVAGFTALAAWWTFWRRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KZ5</accession>
    <name>Q63KZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524162.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111226.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1218"/>
    <dbReference type="EnsemblBacteria" id="CAH38685">
        <property type="protein sequence ID" value="CAH38685"/>
        <property type="gene ID" value="BPSS1218"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1218"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4459"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITHLGEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="271"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="517" mass="55031" checksum="12543526C2DBD2A5" modified="2004-10-25" version="1">MRSLSLNQKLTSMIVILWIGLLLIGATGAWQNRSSMIADRREQLAYLTAQAYNVSEHFYKLSQQNAMPEADAKRAALEAIAAMRYGKDGYLSVNDSKPVVVMHPIKPELNGKDVSGFTDPGGKHLFVEIVKAGNAEGGLGFVDYMWPKPGADKPIDKTSAVRHFAPWDWYLVTGMYMDDLQAAVLASTGRWLAMTAVLGAAATILMVLVLRSVRSSLGGDLEAAVATAQRIAQGDLTAHVDIRGGDRKSLLHALHTMQTALIDMVSRVRLGTENINVGASEIAAGNTDLSQRTEQQAAALVETASSMDEMTTNVKQNADSASQAAELADQAAQVATRGSSVVDDVVRTMDEITDASRKIGDIIGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLAQRSATAAKEIKSLIETSNTTVEHGATLVTRAGTTMTEIVQSVRRVNEILEEISHASREQSAGIDQVNRAVGEMDQVTQQNAALVEQAAAAAHSLKDQADALRSAVAQFALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L01</accession>
    <name>Q63L01_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111220.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1212"/>
    <dbReference type="EnsemblBacteria" id="CAH38679">
        <property type="protein sequence ID" value="CAH38679"/>
        <property type="gene ID" value="BPSS1212"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1212"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5383"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTREFID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021692">
        <property type="entry name" value="DUF3274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11678">
        <property type="entry name" value="DUF3274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="730" mass="80979" checksum="31F1D2F3B15C1E82" modified="2004-10-25" version="1">MTMANRPGDRPVPIPRDLPGVVIFIHGVNDPGAAYATVERGLCQGLNERLSRSDLRPGEYGGEYAEAIKAKDQKSPFFDSRIANDPDMYLYRRAETGGTHSMFLPFYWGYRASDDEIAKISHPGEVKSRVADSDGNLMTRGQYQDIHGNRLDAHFGKGGGFFANATNNIPQMYSPGFEPDKLERTVMQNALAGNTIFAGKSPDRRYFVLAAARLASLIRTIRAVRPSALALEHGMDPRHETITVMGHSQGTIITLLAQAMLRQQGQRCVDCIIMVDTPYSLQFTQDGSQQTGHAKLKTLVDIVNAVTSEPHTIPELAELMIDSAHSCGRAGQNWSKTQGKRPDKGGKHWITFDERDNRGKVYLYFCPEDTVVGLDKVRGIGTFGVPDEVPADGAAASRGKTMPAMTVLEPKRFFQRMWTRLERDQDGRGKRSKVAVGTPPARVPVRDPFQRLTPGPDTDGTMLGTLVESGKNMALQASFKRNDIRFINGEQLKPAYEPDLYGGEVRKGGQVPGHADVAGLMRPDDVTKNVALGNQYAKFKWKDVATTDDPGAGIEPHKQAFNRGRPVDEQSHNWRIVPSRSLGSMLSAAATGGRYQTYVIQREETPDEVRKRMRTDADQLEANNYHSGVLLSSENHRWVTAMDVAIGQAVTLDDPDWRRLLLLMADWKMTPDAMDKIAKCNAYGRLETHTREFIDACAKYYQNGSFPAEKFVPLTLPPLVTSELKVDKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LK4</accession>
    <name>Q63LK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524102.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111017.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1011"/>
    <dbReference type="EnsemblBacteria" id="CAH38472">
        <property type="protein sequence ID" value="CAH38472"/>
        <property type="gene ID" value="BPSS1011"/>
    </dbReference>
    <dbReference type="GeneID" id="56530532"/>
    <dbReference type="KEGG" id="bps:BPSS1011"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4187"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TTLGLWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="480" mass="48977" checksum="2A93BA73E440AF49" modified="2004-10-25" version="1">MTSEISGKRRWYALVVLCLGVLMIVLDTTIVNVALPSIAAELRFSENALVWVVNAYMLTFGGCLLLGGRLGDLYGHRRLFLAGVTVFTAASLACGLAQTQLVLIAARAAQGIGGAVVSSVALSLIMTLFVEPGDRAKAMGVYGFVYAGGGSLGVLLGGLLTSALSWHWVFLVNLPLGAVVYLLSSALLPKARAQATRAPLDIAGAVTVTAALMLAVYAVVNGNAAGWLSARTLSWLGGAAALFAAFVAIEARVAHPLMPLALCMKRNVAIANLIGILWAAAMFAWFFLAALYLQRVLGYGPLQIGLAFLPANLIMGVFSLIVSALLVVRFGIRVPIAAGLLAAAAGLMLFARAPVGGDFVADVLPGMILLGTGAGIAFNPVLLAAMSGVDPADSGLASGIVNTSFMMGGALGLAVLASVATARTDALLAARTAVPAAMAGGYHAAFMLGAAFAIVAALIGMRLRAAPNPAAMQGLQGATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LQ2</accession>
    <name>Q63LQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543426.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110969.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0961"/>
    <dbReference type="EnsemblBacteria" id="CAH38423">
        <property type="protein sequence ID" value="CAH38423"/>
        <property type="gene ID" value="BPSS0961"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0961"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7275"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="18209" checksum="DA5D1FECD13F4AD8" modified="2004-10-25" version="1">MSDFIKIAKVAAQIDWQWDGEWWVREASRLGFKHEKSSASLEVHADPDGNAWRARVKEGKILFIEITFEKFVDVESLSVSEYEDKVDEFFARFEAAVAELTPALGKPVFSDGAAAKGFPDDQEANWLALWRVKNARLMLEQKHESREFPFRLCFVIAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LX0</accession>
    <name>Q63LX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551578.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110901.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0892"/>
    <dbReference type="EnsemblBacteria" id="CAH38354">
        <property type="protein sequence ID" value="CAH38354"/>
        <property type="gene ID" value="BPSS0892"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0892"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7185"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYPVRMY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="111"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="316" mass="34075" checksum="787B58D29C9394EA" modified="2004-10-25" version="1">MAKTTTTAAGRPAADAASAKSRRAAAGARPELDAADDEAAGGASSYLVPGLERGLRILSEFSAREPVLSAPELSKRIGIPRTTTFRLLQTLEALGFIERANGDRHFRLGIGVLRLGFEYLNSLELTDLGAPVLERLRDAAGLSTHLLIRDRRDVVFVAKAQSNASMFGSVKVHVGTRLPAHATVHGHVLMGDLTRDAMRQLYPEKRLEAFTEHTPATVDELYERVRHYARLGYALSEGAFESGISAVTAPVRDHSGSIVAAITATVPRSEIGAVDEKERLVELVCGAAVDLSQRLNYRPLDGDPTVAHARHKVALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LY2</accession>
    <name>Q63LY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110889.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0880"/>
    <dbReference type="EnsemblBacteria" id="CAH38342">
        <property type="protein sequence ID" value="CAH38342"/>
        <property type="gene ID" value="BPSS0880"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0880"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4977"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHCREES"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="136" mass="15289" checksum="593A49EDE5552C5D" modified="2004-10-25" version="1">METVMRNRIYQLTELDVARLEKHAERNPRYQEMLDTLLERADIVEPNKIQANVVTMNSQIKLLDETAGQDRAWTIVYPDAANFEQGRLNVFSPVGMALLGSRCGERVKVTLPGGADATLKIVEIVYQPEASGDYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M07</accession>
    <name>Q63M07_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative inosine-uridine preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205474.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110864.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0852"/>
    <dbReference type="EnsemblBacteria" id="CAH38315">
        <property type="protein sequence ID" value="CAH38315"/>
        <property type="gene ID" value="BPSS0852"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0852"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7138"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REKAHEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="7"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="33632" checksum="182183BEA9C44D98" modified="2004-10-25" version="1">MSLHKILYDTDPGVDDSMALVFQALHPDIELLGVTSVFGNATIDTTTRNALYLAGRFAPGVPVARGAAAPLRRPAPEPLGGIHGDDGLGNTGLSVSVDVAAAPNLDARPAHRFIIDTVRAHPHEITLLAVGPLTNLAHALAEDPQVAMLVKQVVIMGGAFGTAGVLGNVSPAAEANIAGDPDAADIVMSAPWPLAVVGLDVTQATIMTTEYLAALRDDAGEAGRFVWDVSRHYEAFHRASAGLAGIYVHDSSAVAYVVAPQLYRTRTGPVRVLTSGIAVGETIQKPAAMTVPAPDWDGRPPRDVCVGVDANALLALYRKTLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M75</accession>
    <name>Q63M75_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528062.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110796.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0787"/>
    <dbReference type="EnsemblBacteria" id="CAH38247">
        <property type="protein sequence ID" value="CAH38247"/>
        <property type="gene ID" value="BPSS0787"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0787"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7039"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICHRALV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="258"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="518" mass="54901" checksum="190FA4E991FAE2F1" modified="2004-10-25" version="1">MNAIAAVTARACTDAGAPVVEARALTKRFGPHIALADVDLCVRAGESHALVGRNGAGKSTLVSILTGLRKPDAGVVRFAGEAAPPLADRDGWRARVACVYQHSTIIRELTVAENLFINRQPTKHGAIDWRALRRDARALLEHWRIDVSENARAGDLTVEARQLVEIARALSYGARFIVLDEPTAQLDGDEIKRLFARIRELQRDGVTFLFISHHLQEVYDICQAVTVLRDARRIVSAPVAALPRDALIEAMTGERGALAVADAARRAPPPDDAPRALEVDGLAGDDYERVSFCVRRGEVVGLAGATSSGRTSVAEAVAGLRAPRAGAVRVDGAALPPADVSAALARGVGCVPKDRHREGLVLGESVAENASMTIAGALGRLGRFGLVPPARKHAFGARMIDALGIVAQGPRQPVSGLSGGNQQKVVMARALANDPRVLVLIDPTAGVDVKSKEALLAVVERVRGGGAAVLVASGELDDLRTCDRVLVMFRGRIVAEFQAGWQDNELIASIEGVDAHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MH2</accession>
    <name>Q63MH2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194658.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110699.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63MH2"/>
    <dbReference type="STRING" id="272560.BPSS0686"/>
    <dbReference type="EnsemblBacteria" id="CAH38145">
        <property type="protein sequence ID" value="CAH38145"/>
        <property type="gene ID" value="BPSS0686"/>
    </dbReference>
    <dbReference type="GeneID" id="56597630"/>
    <dbReference type="KEGG" id="bps:BPSS0686"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6899"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVETNAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="467" mass="51749" checksum="886FD9D2497268EF" modified="2004-10-25" version="1">MTRQIRFNAFDMNCVGHQSPGLWAHPRDESWRYRELSYWTGLARLLERGKFDGLFIADVLGIYDVYQGSGEAAIRQGAQVPVNDPILLVSAMAAATRHLGFGITCSLSYEHPYPFARRMSTLDHLTGGRVGWNVVTSYLDSAARNLGLPRQANHDERYAIADEYLEVCYKLWEGSWEDGAVVRDAARRVFAEPSKVHPIDHRGRYYDVPGIHLCEPSPQRTPVLYQAGASRRGKDFAAQHAECIFVAAPSRTILKAFVADIRARVKRFGRDPRDVLIFNLHTVITGRTSADAHAKHADYRRYASDEGALALMSGWTGIDLSKYALDEPLEHVESNAIQSAVEALSSADPTRKWTVREIARWGGIGGLGPVSVGDAREIADDLQSWVDETDVDGFNLAYAVTPETFVDVVELVVPELQRRGAYQTDYAPGTLREKLHRAGPRLAAPHPAARYRVGGEPAAAGRLAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ7</accession>
    <name>Q63MJ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110674.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0655"/>
    <dbReference type="ESTHER" id="burps-q63mj7">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38114">
        <property type="protein sequence ID" value="CAH38114"/>
        <property type="gene ID" value="BPSS0655"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0655"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4700"/>
    <dbReference type="eggNOG" id="COG2939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SGHMLYL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="554" mass="60757" checksum="0F22AB51B5EB1954" modified="2004-10-25" version="1">MSAGNSPAIVPSVPAATPATPTATAAESEQDVFARTAPADKVLDDSNVYDTTKDGSIALSKVNEDSSVKRHTITINGKVLPYVARAGHLVAYRQNGAGKKAEAAIFYTAYTRDALPKEHRPVTFLWNGGPGSASIWLHMGSWGPKRLKSDAPNMADPTKQPDSFPFEDNAISLLDQSDIVFVDPPGTGLSTAIAPLKNGDLWGTDDDAQVVADFITSYTNKYNRQSSPKYLYGESYGGIRTPIVANLLEQAGTSGYVPDPSGKPARVLDGFILNSPLVDYNSNCDMMGGRVTCEGYIPSYAMTADYFKKSVKRGTRTQEQYLGELRTLARTTFQTTYGTYFTNGKPNSQWNAYAASTAGQALLNRIADYTGIPASTWNGSFNYTPRPFRNALVPGYELGRYDARMKVPNGNSFAADSYIDVAFLNQLKTYFPDFVNYKTQSIYEPLNNATIRNWKWKRAGSKYDYPQSITDIQAVLTANPDAKLLILHGYEDIATPGFQTELDLEGVNLSDRIPVKWFEGGHMIYNTEASRVPLKQAIDSYYKSPTRIADGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MV4</accession>
    <name>Q63MV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530800.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110565.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0544"/>
    <dbReference type="EnsemblBacteria" id="CAH38001">
        <property type="protein sequence ID" value="CAH38001"/>
        <property type="gene ID" value="BPSS0544"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0544"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6711"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDFHFVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="36360" checksum="6982B88189A778B0" modified="2004-10-25" version="1">MKVNLKALSEALGLSRTTVSRALNGYDDVSEATRERVMQAAREFGYVADPTARRLATGRADAVGIVYPFGAGDLGDPRFAEVVAGVTERLGESGLDFFIVSARPNAELDTYRRLVDGRLVDGLIVARTLVDDPRLRFLQEREFPFVAYGRTASAKPYTWFDFDNEAGMHAAAQRLIAFGHRRIALVCAPRTLNFAAQRRAGFERALREAGIEPDAALIVECAFTRDGGYGAAQTLLALERAPSAIVVDNNIAGAGVFRAIVERGRRFVRDVSLIVYDGVSPDVSFPHHASAVLQPTGHASGRAIAELMLGAIAHPGDAAHRLVSPVIEPGDTDGPFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N17</accession>
    <name>Q63N17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110502.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37936">
        <property type="protein sequence ID" value="CAH37936"/>
        <property type="gene ID" value="BPSS0480"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0480"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4486"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="40" mass="4801" checksum="0D2A497D1E126607" modified="2004-10-25" version="1">MIDNSIKKIFVVLFLYLKLSMDYRDLAANIFRMQNDVVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N32</accession>
    <name>Q63N32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putrescine ABC transport system, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">potH</name>
        <name evidence="6" type="ordered locus">BPSS0465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530774.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110487.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0465"/>
    <dbReference type="EnsemblBacteria" id="CAH37921">
        <property type="protein sequence ID" value="CAH37921"/>
        <property type="gene ID" value="BPSS0465"/>
    </dbReference>
    <dbReference type="GeneID" id="56531084"/>
    <dbReference type="KEGG" id="bps:BPSS0465"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6612"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPIAYGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="108"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="326" mass="35824" checksum="F2C88D8331AE6271" modified="2004-10-25" version="1">MRTSPSSPLAAAAPAARSAFSARARAARVAARFTPSGRSVAIGVPFLWLALFFALPFVLVLKISFADQVMGIPPYTALMDVKDGAVRFALQLGHYAFLLQDSLYVATYVSSLKMAAVSTLLCLLIGYPMAYYIARCAPATRNLLMMGVMLPFWTSFLIRVYAWIGILKDDGLLNHALIAIGLIHSPLRLYHTDAGVYIGMVYSYLPFMVMPLYAHLVKMDLTLLEAAYDLGAKPWVAFTRITLPLSKNGVIAGSLLVFIPAVGEYVIPELLGGADTLMIGRVMWDEFFNNMDWPMASAVTVAMVLLLLVPMAVFQYYQVKELEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N43</accession>
    <name>Q63N43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525482.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110476.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0454"/>
    <dbReference type="EnsemblBacteria" id="CAH37910">
        <property type="protein sequence ID" value="CAH37910"/>
        <property type="gene ID" value="BPSS0454"/>
    </dbReference>
    <dbReference type="GeneID" id="56531095"/>
    <dbReference type="KEGG" id="bps:BPSS0454"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6601"/>
    <dbReference type="OMA" id="GAAHSMH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266178" evidence="2">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="98" mass="9805" checksum="FCE73BBFF17E6D24" modified="2004-10-25" version="1">MRKISAALLGASAAWPALVHATTAFADPADAAASVPAIVAPSALDDYRRYRDDDGPNWPQLNREVAPRPRKAAAAPAGADGGAAAGAHGHGAMHGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NC8</accession>
    <name>Q63NC8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Bacterioferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bfr</name>
        <name evidence="8" type="ordered locus">BPSS0371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Iron-storage protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Oligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188572.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110391.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0371"/>
    <dbReference type="EnsemblBacteria" id="CAH37819">
        <property type="protein sequence ID" value="CAH37819"/>
        <property type="gene ID" value="BPSS0371"/>
    </dbReference>
    <dbReference type="GeneID" id="56597023"/>
    <dbReference type="KEGG" id="bps:BPSS0371"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6496"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQRLFHV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="4 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="18506" checksum="A9CADF2578E9B7DB" modified="2004-10-25" version="1">MQGDKKVIEYLNAQLKNELTAINQYFLHARMYKHWGLEKLGKHEYDESIGEMKHADWLIERVFMLDGLPNLQDLHKLLVGEETEEILKCDLKLEQVSQATCKEAIAYCESVRDYVSREIFEKILDDTEEHIDWLETQIDLIGKVGIQNYQQSMMGSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NP2</accession>
    <name>Q63NP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523471.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110277.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0258"/>
    <dbReference type="EnsemblBacteria" id="CAH37704">
        <property type="protein sequence ID" value="CAH37704"/>
        <property type="gene ID" value="BPSS0258"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0258"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6345"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTLYPSQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="26132" checksum="395020C4336A3449" modified="2004-10-25" version="1">MTNLWDRAFDLTGRVALVTGGAAGIGHACARLLAQRGASVALVDRHPETAGIAAKLEGGAARHSGMSLDLRDCSAAQAGVALAASRFGGVDMLVNSAGVALLDKALDVGEAAWDATMAINVKASFFVAQAAARQMIAGARGGRIVNLASQASVVGLERHAAYCASKAAIVGMTKALALEWAPHGITVNAVSPTIVETALGKQAWAGEAGERAKREIPAGRFAQPDEIAALVLYLLSDAAAMMTGENVVIDGGYTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P02</accession>
    <name>Q63P02_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Porin_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538878.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110167.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0146"/>
    <dbReference type="EnsemblBacteria" id="CAH37591">
        <property type="protein sequence ID" value="CAH37591"/>
        <property type="gene ID" value="BPSS0146"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0146"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6196"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GASYPTM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Porin_4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="22569" checksum="11B7CD04E6567246" modified="2004-10-25" version="1">MAGGFANDRLYGAALQYQRGGLTVGASYPKMNRARSADAAGAVTGDNTFDASSQRNVGIGATYAFSKALIGFAYSHVGVYDPTSNAYFTGTTRPAGGHWQSWKFDHFEINGRYRVTPAFYAGAAYTYTQARADSTAGAFHPKWRPLSTKLDYDLSKRSSGFAEGVYQHAQHAMNARTGTDFDHAYIPGAANIASGPNQYVVRPALLHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P51</accession>
    <name>Q63P51_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110118.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0095"/>
    <dbReference type="EnsemblBacteria" id="CAH37541">
        <property type="protein sequence ID" value="CAH37541"/>
        <property type="gene ID" value="BPSS0095"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0095"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4018"/>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWRARCI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DotU" evidence="1">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="24260" checksum="0F276B16CAC5E2E0" modified="2004-10-25" version="1">MLLQDTMLHVALLTQGARISRVHDWRARCIALVRQFEQALQDGGYRSGIANELGLAQCVFLDEITMRNLSTEQKEEWLRELLQFRFHSIRDGLSKVRARIDRLCRGHSANAALLEMYSLFHEFGLLGDKQGHALADARVSEARPTPGKKAAETAEIWKDGGAANEAAHGRSWRIVGGLLAFAALMTMWLVIDTRLSHEVEQMEVTSGDEAAIHPASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P57</accession>
    <name>Q63P57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110112.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0089"/>
    <dbReference type="ESTHER" id="burps-a4lm41">
        <property type="family name" value="PhoPQ_related"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37535">
        <property type="protein sequence ID" value="CAH37535"/>
        <property type="gene ID" value="BPSS0089"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0089"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4011"/>
    <dbReference type="eggNOG" id="COG4287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VPKYIVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009199">
        <property type="entry name" value="PhoPQ-act_pathogen-rel_PqaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31497">
        <property type="entry name" value="PTHR31497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10142">
        <property type="entry name" value="PhoPQ_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014728">
        <property type="entry name" value="PqaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266641" evidence="1">
        <location>
            <begin position="24"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="495" mass="54854" checksum="BE02DEB8C7CAAA2C" modified="2004-10-25" version="1">MRNKVAGAIALSMLSLAYPRAEAAPIAFPCPIDARRDLTDTLACYRQTVENQPLNYTMTGIVQLPGIEQRTYRLVSQSWSPDQLVRPDTWVHEVALYIPQDALPRRALVIANDGTRHPGEGETPRTPNDFLPDTLADIARSTRTAVISVSDVPNQLLSYADDGKPKAEDDSVARSWTLFMQSPHTRGAMPLHVPMAASIWRAMSLAERELTSLGIHRFVVSGISKRAWTTWLALIGDQRVDAIAPFAIDLLSTRAALENMYRSYGGNWPLAFYPYYAEGIDRTLDSPAFGLLMRIEDPLSYLGTRHGSRLAVPKYIVNASGDDFFVPDNSQRYFDKLPGAKALRMVPNSSHSDIRRATLDSLVPFVKRIQHGKALPQVDAAPIETNGQTILRLRTSERPRQLLLWQATNPLARDFRYACGIRYTSTPIAMNGARPQQLVLVPPTNGWRAYFVEATFDDGFVATSQTYILGDGYPSTSPPAVGGSCRTLPGRDTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PC5</accession>
    <name>Q63PC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110044.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37463">
        <property type="protein sequence ID" value="CAH37463"/>
        <property type="gene ID" value="BPSS0020"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0020"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3927"/>
    <dbReference type="eggNOG" id="ENOG5031702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTKESHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="10166" checksum="46750411AD78A411" modified="2004-10-25" version="1">MSNENETARLRASPPGYASMTRHHTHAGIPRTLKIVGYCGLAAIALALFVAMCAILKDSALDREAARQLQNGNVELHGGADVEPGSTNNAAQARTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PD7</accession>
    <name>Q63PD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196513.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110032.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63PD7"/>
    <dbReference type="STRING" id="272560.BPSS0008"/>
    <dbReference type="EnsemblBacteria" id="CAH37451">
        <property type="protein sequence ID" value="CAH37451"/>
        <property type="gene ID" value="BPSS0008"/>
    </dbReference>
    <dbReference type="GeneID" id="56596751"/>
    <dbReference type="KEGG" id="bps:BPSS0008"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6003"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WFGQPDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="205" mass="22374" checksum="C9BBB36231EEEADE" modified="2004-10-25" version="1">MDTKPDLAPAAGARERLLDAAETLIYAGGIHATGVDAIVKRSGAARKSFYAHFESKEALVAAALERRDARWMAWFVEATKKRGKTPRARLVGMFDVLREWFEQADFHGCAFLNAAGEIERADDPIRVVVREHKARLLAFVREQLDAHAAQAGADRRFVARLARQWLVLIDGAIGVALVSGDASAARDARAAAELLLDATLPNRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM9</accession>
    <name>Q63PM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative bacteriophage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109940.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3344"/>
    <dbReference type="EnsemblBacteria" id="CAH37357">
        <property type="protein sequence ID" value="CAH37357"/>
        <property type="gene ID" value="BPSL3344"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3344"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1861"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWWGRVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="100"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="32104" checksum="B9D243F484D4047C" modified="2004-10-25" version="1">MTFEEIVGIYLSAKDHRSKQRDMYSLKRLQPYFGGRAISALKRVDVRKYVAVRLADGVQESTVKRELKFLSAAINFVRLECDCSDLPNPAQSLGLNGGEHRVRWISRAEASALILSASAYAKRPHLANFVRLALSTGCRKNELLALDWCRVDFEHSFLRLNAEHTKNGKRRVVPLNSAALSALRDQRDWVERKCSGSEWVFPAWSGKRIQTLQKGFNAACARVGIENFRIHDLRHTFASWLVMEGVSLYVVKDLLGHSSITVTERYAHLSPDQGRAAVQKLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PP4</accession>
    <name>Q63PP4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rieske [2Fe-2S] domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL3329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545319.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109925.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3329"/>
    <dbReference type="EnsemblBacteria" id="CAH37342">
        <property type="protein sequence ID" value="CAH37342"/>
        <property type="gene ID" value="BPSL3329"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3329"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1885"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPLAVEN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="354" mass="40190" checksum="2455B7A10D710644" modified="2004-10-25" version="1">MNFDTDLLHRHWHLGCHRRELPNDGDFVRFDTAIGEIVIFNDAGELVAFDNRCPHRGARMYVDDSGNQPASCPYHGWTYREGRLLIPGRERFDGCALERAKLRTFAVDWCGDFLFFAAHPQTDLYTQLGRFAEAVENISFNIDRRLDLNRYDFECYWPLAIENALEPYHIGAVHPQTLATLGLEDGENVFDGVNCAWYAPVGASRQRNQLARLKRFFNLDYQYEGYASIYLFPFTMISSTYGYSYSLQHFLPAGVGGDRTRFTSRLYAAPAASEQAAQALGAFFESTRDVNRRVFEEDHAICKRMPRNAWSMAPLACAADTEAKIDHFRRACRTFAASRAALPVVDATREAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PV1</accession>
    <name>Q63PV1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome c-551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109867.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3271"/>
    <dbReference type="EnsemblBacteria" id="CAH37284">
        <property type="protein sequence ID" value="CAH37284"/>
        <property type="gene ID" value="BPSL3271"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3271"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1952"/>
    <dbReference type="eggNOG" id="COG4654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGCHQVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266232" evidence="5">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="115" mass="11901" checksum="EF73C9478CB8007B" modified="2004-10-25" version="1">MKRTMSAAAAAMAVVSCAMAAAPAAHADAGDGLKVARSNACMGCHAVDRKLVGPSFQQIAERYKNDKQAEPKLAKKVKDGGSGVWGAIPMPAHPRMSDADVRSVVQWVLAGAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PW6</accession>
    <name>Q63PW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524380.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109852.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37269">
        <property type="protein sequence ID" value="CAH37269"/>
        <property type="gene ID" value="BPSL3256"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3256"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1968"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INYQWPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="21"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="468" mass="50875" checksum="69E6B0D62E681105" modified="2004-10-25" version="1">MQKGHSETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFVIMRALGEMAVHEPVAGSFSRYARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKVVTIVVMIAVGIAMIAFGIGNHGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAANPQKTIPGAINSVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGHAPRTFGETTASGVPRRAIVVSMAALLVGVLLNYLVPEKVFVWVTSISTFGAIWTWGVILVTQMKFRASLAPAEERALRFRMPFWPYASWVALAFLVLVIGLMAYFPDTRIALYVGPAWLVLLVVLYFVLKLEPEGGKAAGLERRYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PX6</accession>
    <name>Q63PX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109842.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3248"/>
    <dbReference type="EnsemblBacteria" id="CAH37259">
        <property type="protein sequence ID" value="CAH37259"/>
        <property type="gene ID" value="BPSL3248"/>
    </dbReference>
    <dbReference type="GeneID" id="56527899"/>
    <dbReference type="KEGG" id="bps:BPSL3248"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1985"/>
    <dbReference type="eggNOG" id="ENOG5033PIE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIRVGYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021340">
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    </dbReference>
    <dbReference type="Pfam" id="PF11170">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267046" evidence="1">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="416" mass="43215" checksum="C41AFCC132BC3F8B" modified="2004-10-25" version="1">MKQRNLILAMACAAPFISACSGGGGGSESQPLVEAALCPSSVDYNTVYTGGGGDGELVKLQIDTTKMTWQITFVESPVPKTTGTAAPTRAGTTQSGTLTQETLLPTQKLNNCAFRLNGASLDPNRPARIFLGMGIVGGTIPGAEIQYGGLLGQGAIPDTTFPYYPFIAFSSLETDVTKLAGTYSQLGYGQVGSQNFAPTTIDAKVTINPDGTWVRCDTTGIYAGTCRQPGTNIVQSADGTGAFETDHYQGQVKPTLATIPQAKGYIIVGKLRNQLVPIMIRTGVANPNPTPDANGVPGLTADDESGISILAPQTAIAVGSQNGEYIGVDSQFDYRTTALVNAQATLLDPFQASQASLATPLNLDYTQAVPGTVTSTHVGASSTTPTGKFIFTGGVFGFLDMSNSSSPYFTVGAFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY4</accession>
    <name>Q63PY4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197901.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109834.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37251">
        <property type="protein sequence ID" value="CAH37251"/>
        <property type="gene ID" value="BPSL3240"/>
    </dbReference>
    <dbReference type="GeneID" id="56594589"/>
    <dbReference type="KEGG" id="bps:BPSL3240"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1997"/>
    <dbReference type="eggNOG" id="ENOG5032PJX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MNTRHIQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266667" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="65" mass="6535" checksum="FD2E037F2A94C6F3" modified="2004-10-25" version="1">MKTRNIQNFLMVSAAFFAMSGPARSEGAGVLATASTQMLQLAAAAGADAPTFAGVATNGRGAMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q40</accession>
    <name>Q63Q40_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol:disulfide interchange protein DsbD</fullName>
            <ecNumber evidence="6">1.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Protein-disulfide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">dsbD</name>
        <name evidence="25" type="ordered locus">BPSL3184</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioredoxin family. DsbD subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555990.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109778.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3184"/>
    <dbReference type="EnsemblBacteria" id="CAH37195">
        <property type="protein sequence ID" value="CAH37195"/>
        <property type="gene ID" value="BPSL3184"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3184"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2054"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CKEMERF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02953">
        <property type="entry name" value="DsbDgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035671">
        <property type="entry name" value="DsbD_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036929">
        <property type="entry name" value="DsbDN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022910">
        <property type="entry name" value="Thiol_diS_interchange_DbsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32234:SF0">
        <property type="entry name" value="PTHR32234:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74863">
        <property type="entry name" value="SSF74863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="18 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 23" id="KW-0732">Signal</keyword>
    <keyword evidence="11 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266242" description="Thiol:disulfide interchange protein DsbD" evidence="23">
        <location>
            <begin position="36"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="24">
        <location>
            <begin position="484"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAH37195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="627" mass="65164" checksum="8B93C37177C6CBFB" modified="2004-10-25" version="1">MFNRIPRHAQSRFCFLIAVVAMLGVLFGTSLAARAADDFLDPAVAFKFSASEAPGQVDVHFKIADGYYMYRERFAFAVKSGSATLGEPQLPAGHVKFDPTFQKNVETYRGDLTIHLPIKQASGPFELAVTSQGCADEGICYPPAEHVARIEGAALGAAGTAPAAAGAGADTSAADGGSWYERVTSADYARSLLEGHGFLTIVALYFVAGMVLSLLPCSYPMIPILSAIIVGEGARATRARAFALSLTYVIGMALVYTALGVAAALVGQSLGAWLQNPWVLGAFALLLTVFALLLIGGVDITLPQRWQNGAAQTSGPRKGGRFAAVATMGALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFSMGIGLGVPLLVIGIGAGTLLPRAGAWMDGVKVFFGVLLLAAALWIVWPVLNAASQLGLGALWLLIAAAALGLFTPHSGSSSVWRRLGRGLGAALAIWAATLLVGLAAGSTDPLRPLAVLAARAAPSNGAAGAGAGAHEGPAFAPVRSIAELDEIVKTSTRPVMLDFYADWCVSCKEMEHLTFTDARVGARLSQMHLVRADVTANSPDDQALLKRFGLFGPPGIIVFDANGQERGRVVGYQSADRFLRSLDRMSLPAAWSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QR5</accession>
    <name>Q63QR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADP-dependent malic enzyme</fullName>
            <ecNumber evidence="11">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">maeB</name>
        <name evidence="11" type="ordered locus">BPSL2959</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="11"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938729.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109553.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2959"/>
    <dbReference type="EnsemblBacteria" id="CAH36969">
        <property type="protein sequence ID" value="CAH36969"/>
        <property type="gene ID" value="BPSL2959"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2959"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2318"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIWVTDL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032683">
        <property type="entry name" value="Malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12434">
        <property type="entry name" value="Malate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
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    </dbReference>
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        <property type="entry name" value="malic"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="10">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="9">
        <location>
            <begin position="172"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
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        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="769" mass="83219" checksum="9F7F16B90D4A4173" modified="2004-10-25" version="1">MSTSSSSSSSKEKLREAALDYHEFPTPGKVAIAPTKQMINQRDLALAYSPGVAFACEEIVENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHDDQHGTAIVVAAAVTNGLKVVGKSIKEVKLVASGAGAAALACLDLLVDLGLPLEHITVTDLAGVVYKGRAELMDPDKERFARETDARTLSEVIDGADIFLGLSAAGVLKADMVKKMAERPLILALANPTPEILPEVALEARPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIEDMEAYKIHLQQFVYHSGTTMKPVFQIARGAPAEKKRVVFAEGEEERVLRAVQIVVDEKLAKPILIGRPAVIEHRIQRYGLRLTPGVDFTIVNTEHDERYRDFWQTYFKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRAGCSVYGAMNALVLPGRQIFLVDTHVNVDPTPAQLAEITIMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAQKMRDTLAILQERAPDLHVDGEMHGDVALDAALRKEILPESTLEGEANLLVLPNIDAANIAYNLLKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMTALLVADVNAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QS7</accession>
    <name>Q63QS7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2947"/>
    <dbReference type="EnsemblBacteria" id="CAH36957">
        <property type="protein sequence ID" value="CAH36957"/>
        <property type="gene ID" value="BPSL2947"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2947"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2333"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQEEGAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="230" mass="25329" checksum="66B5E3BCDEE72B07" modified="2004-10-25" version="1">MKNVPHTVTDAAIATIRERIERGFYPVGSLLPAQRQLSEELEISRASLREALSTLEALGMLRIRPGKGVYVESAQASAAHAWRFAEQSSLPDTYQMRYALEGFAARMAALAVSEEDLAWFEENVAALQEALANDELDSASQLDFDFHMRIVSLAGNAAIESILRGSADIMKESQRMPFYRRELVLSTYREHRAILDALIAKDPAAAGAAIEAHISNAAQRAGVFFPTPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RD7</accession>
    <name>Q63RD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185643.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109331.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2735"/>
    <dbReference type="EnsemblBacteria" id="CAH36743">
        <property type="protein sequence ID" value="CAH36743"/>
        <property type="gene ID" value="BPSL2735"/>
    </dbReference>
    <dbReference type="GeneID" id="56594940"/>
    <dbReference type="KEGG" id="bps:BPSL2735"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2587"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMQPWDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="219" mass="24588" checksum="21029816AE6D4E2D" modified="2004-10-25" version="1">MRFDEPAIAAVYRAIFERRDMRHFTSAPVDPAVLARLLRAAHHAPSVGFMQPWRFIRVTDPALREQIHALVDAERRATADALGERHDEFMRLKVEGVRECGELLVVALADGRERHVFGRRTLPEMDLASAACAIQNMWLAARAEGLGMGWVSLFDVDALRRLLAMPDGATPIAVLCLGHVDAFYAKPMLEQERWATRMPLEACLYENGWDAPPTSARNT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RN4</accession>
    <name>CRCB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crcB</name>
        <name type="ordered locus">BPSL2638</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186560.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109234.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RN4"/>
    <dbReference type="SMR" id="Q63RN4"/>
    <dbReference type="STRING" id="272560.BPSL2638"/>
    <dbReference type="EnsemblBacteria" id="CAH36646">
        <property type="protein sequence ID" value="CAH36646"/>
        <property type="gene ID" value="BPSL2638"/>
    </dbReference>
    <dbReference type="GeneID" id="56594837"/>
    <dbReference type="KEGG" id="bps:BPSL2638"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2710"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000110080" description="Putative fluoride ion transporter CrcB">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <sequence length="128" mass="13522" checksum="5C758EE71867F6DF" modified="2004-10-25" version="1">MFYSIVAIFVGAGFGALLRWFLSIGLNALLPEVPLGTLASNLIGGYLIGIAVVAFATRAGLPPEWRLFVITGFMGGLTTFSTYSVEVMTHAVQGEFGWALAVAALHLIGSFTLTGLGMWTARAWLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RS3</accession>
    <name>Q63RS3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109194.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2598"/>
    <dbReference type="EnsemblBacteria" id="CAH36606">
        <property type="protein sequence ID" value="CAH36606"/>
        <property type="gene ID" value="BPSL2598"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2598"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2962"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATEIYAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="190" mass="20445" checksum="21C12F0E946683A5" modified="2004-10-25" version="1">MTHAPLSVEANGLLSEGGCACMSSTLTVRRIAADQGGVYRELRAASLREPYASGETPEAELAVDAARAAAIAQQRAASDESTTFVLYTEGHPAGMIGAYFDGTPARRAFVSELWVAHAVRHLRGGVLLVNTARAWLATRGAGEIYAWIADQNRSAIRFYEHVGFADTGERAPITRVPGAMKSLFVWREHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW2</accession>
    <name>Q63RW2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522323.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109155.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36566">
        <property type="protein sequence ID" value="CAH36566"/>
        <property type="gene ID" value="BPSL2558"/>
    </dbReference>
    <dbReference type="GeneID" id="56528625"/>
    <dbReference type="KEGG" id="bps:BPSL2558"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2807"/>
    <dbReference type="eggNOG" id="ENOG5030BRP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PREAPCD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9996" checksum="42A73C4BA8784678" modified="2004-10-25" version="1">MLNGIKRFAHRLGIARRSNSGRAPAASTTFATEFDATWHGDHWQNLLASPLDARHYVMEDWAQPVMPEPDEQAHASPPGRRKRWYEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S63</accession>
    <name>PNCB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nicotinate phosphoribosyltransferase</fullName>
            <shortName evidence="1">NAPRTase</shortName>
            <ecNumber evidence="1">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pncB</name>
        <name type="ordered locus">BPSL2462</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192078.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109054.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S63"/>
    <dbReference type="SMR" id="Q63S63"/>
    <dbReference type="STRING" id="272560.BPSL2462"/>
    <dbReference type="EnsemblBacteria" id="CAH36465">
        <property type="protein sequence ID" value="CAH36465"/>
        <property type="gene ID" value="BPSL2462"/>
    </dbReference>
    <dbReference type="GeneID" id="56528722"/>
    <dbReference type="KEGG" id="bps:BPSL2462"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2928"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QAVFHRY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205826" description="Nicotinate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00570"/>
        </source>
    </evidence>
    <sequence length="399" mass="45962" checksum="64300451032C4FA1" modified="2004-10-25" version="1">MIITSLLDTDLYKFTMMQVVLHHFPAASVEYRFKCRTPGVDLVPYIDEIRAEVRSLCELRFTDSELDYLRRLRFVKSDFVDFLALFHLNEKYISITPSQKGGGEIDIEIKGPWLHTILFEIPVLAIVNEVYFRNTQRRPDYREGRGRLREKIKLLGAKPEFADCKIADYGTRRRFSKVWHEEVLRTLQDGLGPQFAGTSNVYYAMTHEITPLGTMAHEYLQACQALGPRLRDSQTYGLEMWAKEYRGDLGIALSDVYGMDAFLRDFDMYFCKLFDGARHDSGDPFDWGERLIKHYEENRCDPRTKVLVFSDALDIPKVMQLYARFRGRCKLAFGVGTNLTNDLGYQPLQIVIKMVRCNGQPVAKLSDSPGKSMCDDKAYLAYLRQVFGITQPPDDDAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S78</accession>
    <name>Q63S78_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TP_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524612.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109039.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2447"/>
    <dbReference type="EnsemblBacteria" id="CAH36450">
        <property type="protein sequence ID" value="CAH36450"/>
        <property type="gene ID" value="BPSL2447"/>
    </dbReference>
    <dbReference type="GeneID" id="56528737"/>
    <dbReference type="KEGG" id="bps:BPSL2447"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2943"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSEAGCP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="25358" checksum="8FAA1BF0BCAA3B6A" modified="2004-10-25" version="1">MTAGTLYLIPNTLGDGDAAMLAAVLPAAVQARAASLGYYIGENAKTTRAFLKKIGTERPIQEIEIRELNVKTPASEIDRLLAPVLAGADAGLVSEAGCPAVADPGALLVRRAHERGVKVVPLVGPSSILLALMASGLNGQSFAFHGYLPVDAAARAKRLRELEQQSRHANQTQIFIETPYRNHAMLDALVATCAPSTLVCVAADLTLATETIASRPAAQWKKAPVPDLHKRPAIFLLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SA0</accession>
    <name>Q63SA0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-hexosaminidase</fullName>
            <ecNumber evidence="9">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagZ</name>
        <name evidence="11" type="ordered locus">BPSL2424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543999.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109016.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2424"/>
    <dbReference type="EnsemblBacteria" id="CAH36427">
        <property type="protein sequence ID" value="CAH36427"/>
        <property type="gene ID" value="BPSL2424"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2424"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2966"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQMAAEM"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00364">
        <property type="entry name" value="NagZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022956">
        <property type="entry name" value="Beta_hexosaminidase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="10">
        <location>
            <begin position="11"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="342" mass="37444" checksum="4BA60ADBA51C9498" modified="2004-10-25" version="1">MKLPPGPVMLDVAGTTLTRDDARRLAHPHTGGVILFARHFESRAQLVALTEAIRAIRDGILIAVDHEGGRVQRFRTDGFTVLPAMRRLGELWDKDVLHATKAATALGYVLASELRACGIDMSFTPVLDLDYGRSKVIGDRAFHRDPRVVALLAKSVNHGLALAGMANCGKHFPGHGFAQADSHVALPTDDRPLDEILANDAAPYDWLGLSLSAVIPAHVIYTQVDSKPAGFSRVWLQDVLRGRLRFAGAVFSDDLSMEAAREGGTLAQSAQAALEAGCDMVLVCNQPDAAERVLDELRTTASRESSRRIKQMRPRGKVLEWRKLMREPRYLNAQGLLRSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD2</accession>
    <name>Q63SD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histidine transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisP</name>
        <name evidence="10" type="ordered locus">BPSL2392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532102.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108984.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2392"/>
    <dbReference type="EnsemblBacteria" id="CAH36394">
        <property type="protein sequence ID" value="CAH36394"/>
        <property type="gene ID" value="BPSL2392"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2392"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3009"/>
    <dbReference type="eggNOG" id="COG4598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FQAYHLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="13"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="29272" checksum="211A6A2F5D4243D3" modified="2004-10-25" version="1">MAETTTTNAACKLEARDIHKRYGDNEVLKGVSLSAKAGDVISIIGASGSGKSTFLRCINFLERPNAGQIVVDGETVRTKADRAGNLEVADHKQLQRIRTKLAMVFQHFNLWAHMNVLENVMEAPVHVLGITKREAQERAREYLEKVGLAPRVETQYPSHLSGGQQQRVAIARALAMHPDVMLFDEPTSALDPELVGEVLKVMQKLAEEGRTMIVVTHEMGFARNVSNHVMFLHQGRTEEEGQPADVLARPQSERLKQFLSGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SS3</accession>
    <name>Q63SS3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193377.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108843.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63SS3"/>
    <dbReference type="STRING" id="272560.BPSL2248"/>
    <dbReference type="EnsemblBacteria" id="CAH36250">
        <property type="protein sequence ID" value="CAH36250"/>
        <property type="gene ID" value="BPSL2248"/>
    </dbReference>
    <dbReference type="GeneID" id="56596039"/>
    <dbReference type="KEGG" id="bps:BPSL2248"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3188"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDDVMLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="27593" checksum="0D70E99A6EF24243" modified="2004-10-25" version="1">MFTRLREDVATIRERDPAARSAWEVLTCYPGLHALVFHRLAHACWRSGWRWLGRFVSQLGRFLTGIEIHPGATLGRRVFIDHGMGVVIGETAVIGDDCTIYQGVTLGGTSLARGAKRHPTLERGVIVGAGAKVLGGFTVGAGAKIGSNAVVVKPVPAGGTAVGNPARVVVPAEAKRTPERTAFCAYGITPNADDPMSLAIHGLIDHAAKEAQRVDEIVVALERLGAHLDALQGTDGARLDLRRLSAAFEGRALDGGTAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T19</accession>
    <name>Q63T19_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL2152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205137.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108747.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2152"/>
    <dbReference type="EnsemblBacteria" id="CAH36154">
        <property type="protein sequence ID" value="CAH36154"/>
        <property type="gene ID" value="BPSL2152"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2152"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3300"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="463" mass="48927" checksum="ACCC7363628FBD0D" modified="2004-10-25" version="1">MNVLVELIAFAVAIGVLVVVHEYGHYRVARWCGVKVLRFSIGFGAPVARWVSKKTGTEWTLSALPLGGYVKMLDERDPGDGIRADELPHAFNRQPVGKRIAIVAAGPVANFLLAIALFSAVFATGVTEPAAIVAPPAAGTPAAVAGFDGGETIVSIRIPGAGGAQEGQAEPVRSWSELRWKLLGAAFDHRDVVLGARNRADGATYDFRVDLHGIADRDVDDDFMSRLGFEPGGGSLTVTSVLPGGAAQRAGLQAGDKLVALDGARIGGSTRFIDDVKAHAGRALALRIERAGAERTVLIVPQAQRDDETGKQVGRIGAALALQTPSVDVRYGVLESVELGARRTWDISVYSLKMFGRMVTGEASLKNLSGPVTIADYAGKSARLGLSAFLSFLALVSISLGVLNLLPIPVLDGGHLLYYLVEAATGKAVSERWQLILQRAGLICIVALSAIALFNDLARLIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T68</accession>
    <name>Q63T68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subfamily M20A unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2101"/>
    <dbReference type="EnsemblBacteria" id="CAH36104">
        <property type="protein sequence ID" value="CAH36104"/>
        <property type="gene ID" value="BPSL2101"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2101"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAVTKSY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010169">
        <property type="entry name" value="AcOrn-deacetyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01892">
        <property type="entry name" value="AcOrn-deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="175"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="389" mass="41796" checksum="E8E88AE1FFCDEF38" modified="2004-10-25" version="1">MAEPISLSWVKQLVSIDTTSRVPNLGLIEMVRDALAAAGVESTLTHDARDGWANLFATIPAHDGTTNGGIVLSGHTDVVPVDGQQWDSDPFKPQVRDGKLYGRGTCDMKGFIGAALALLPEMQAAKLAQPLHFALSFDEEIGCVGAPLLLADLKARGVAPAGCIVGEPTGMRPVIAHKGINVYRCCVRGHAAHSSLTPKGLNAIEYAARLICHIRDLADEFRAQGPFDALYDVPFTTAQTSLIQGGNAVNTVPAECQFSFEFRNLPTLDPDAIFARIDAYARDTLLPRMRREHPNAAIEFSKVAAAPGLDAAEQAAITELVRSLTADQEKRKVAYGTEAGLFQRAGIPSVVCGPGYIEQAHKPNEFVELEQLASCERFVRKLVQGMTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TF5</accession>
    <name>Q63TF5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108611.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2013"/>
    <dbReference type="EnsemblBacteria" id="CAH36012">
        <property type="protein sequence ID" value="CAH36012"/>
        <property type="gene ID" value="BPSL2013"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2013"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2271"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDAYRWT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="157" mass="16996" checksum="9EB4392CDE030E1D" modified="2004-10-25" version="1">MKPPGRTRARTVSCGVVLLDSDGRVLLAHATDTTHWDIPKGQGEPGETAQQAALRELAEETGIVLDPARLVDLGLFAYRRDKDLHLFAARAAAGETDLSRCTCTSMFPSRRDGTMIPEMDAFRWTAPADVDAYASRSLARLFGTTLSLAALHRTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TR1</accession>
    <name>Q63TR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191720.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108505.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1905"/>
    <dbReference type="EnsemblBacteria" id="CAH35905">
        <property type="protein sequence ID" value="CAH35905"/>
        <property type="gene ID" value="BPSL1905"/>
    </dbReference>
    <dbReference type="GeneID" id="56595447"/>
    <dbReference type="KEGG" id="bps:BPSL1905"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4049"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKAWYES"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="136" mass="15663" checksum="9BAB3A7DD9ECD197" modified="2004-10-25" version="1">MTPYRDITDEEWQRVAPLLPELRPRKELRGRPLADTRAVLNGVLWVIYSGANWSAMPRRFPAYQTCHRRFKAWHESGALKRVLIELFGTQSDDLCELMAMRMRTHARSKAAQARSEAASTTSSPVPRHDHTLEHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TT3</accession>
    <name>Q63TT3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108483.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1884"/>
    <dbReference type="EnsemblBacteria" id="CAH35883">
        <property type="protein sequence ID" value="CAH35883"/>
        <property type="gene ID" value="BPSL1884"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1884"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4025"/>
    <dbReference type="eggNOG" id="ENOG502Z84D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYPEYEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011465">
        <property type="entry name" value="DUF1571"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07608">
        <property type="entry name" value="DUF1571"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267138" evidence="1">
        <location>
            <begin position="41"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="35176" checksum="EB9683CD4F43730D" modified="2004-10-25" version="1">MSHTLPLHPSSSSRTRFARRRLATASAALSLMLGHGAAHAQANAEASAAVESGAQEAALPAELAKVAKLPVEQQARWLRTAARQGTLEKLDDATLTALFKSLDPQTVPDYVAAGPIGHPSYEFTMLRQERISGKWSDTPDHMLVKVTRSPLRVYAKWLPDGAHSGQEVIYDSAKRADEMYGHLGGLLGKVPMWTAVDGTLARAQSNHQVRDLGTEFVANLYLTEAKKYREAGALKPTHVEAKTVKGVRVVALTYETPGGRPQFYAKKETLGLDLRQPYFRTVESYDNDGRVFEKIVFEKITPKSLDETAFDPKNPDYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U39</accession>
    <name>Q63U39_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative siderophore-related non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108377.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1777"/>
    <dbReference type="EnsemblBacteria" id="CAH35776">
        <property type="protein sequence ID" value="CAH35776"/>
        <property type="gene ID" value="BPSL1777"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1777"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1996"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MFRPGDD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1065"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1748" mass="185452" checksum="561A5B0962200650" modified="2004-10-25" version="1">MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAAYHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGPLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWLDAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARASGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFAEVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHALDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGVSGEPAGAAVPRERAGQAGGEPFVPVHDRIAQHARRRPDARGVADIGRALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIAHVITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPDYMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHAAVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADALAPFDLAADAPLWRARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQAPADAPQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDAALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARAARALAELWRASLGHAAPAPEANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UA9</accession>
    <name>Q63UA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HNS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550461.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108307.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1706"/>
    <dbReference type="EnsemblBacteria" id="CAH35704">
        <property type="protein sequence ID" value="CAH35704"/>
        <property type="gene ID" value="BPSL1706"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1706"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GERYLEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="12419" checksum="97A8C3B6EAEE50F8" modified="2004-10-25" version="1">MTNRYLDLMKRHRALQEEIAAVRRHDTREIVTCIVQMMMMYEICLDDISDALPRQQRLGLRRRRTPKYMDPESGRTWSGYGRPPRWMAGRDPAEFLLPAASEQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB6</accession>
    <name>Q63UB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521496.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108300.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1695"/>
    <dbReference type="EnsemblBacteria" id="CAH35694">
        <property type="protein sequence ID" value="CAH35694"/>
        <property type="gene ID" value="BPSL1695"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1695"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3775"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFHVVDD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="222" mass="24904" checksum="D2686C6D9C90B922" modified="2004-10-25" version="1">MTSSSNQKNVAERVTEQIRESIVHGNFAPGQRLSEAALSENLQISRNTLREIFRILTKEGLLKHEPNRGVSVAIPSIATILDIYRVRRLIECQAIAQAYPSHPAKKHLRDAVEMGLRCRDSGDWQGVGTANMEFHMAIVELADSERLNVMFSHVLAELRLAFGMLQDPEFLHGPYVELNLQILQLFESGKLAECATALNDYLAQSERIVLSACARHPVFKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UC5</accession>
    <name>Q63UC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535871.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108291.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1681"/>
    <dbReference type="EnsemblBacteria" id="CAH35680">
        <property type="protein sequence ID" value="CAH35680"/>
        <property type="gene ID" value="BPSL1681"/>
    </dbReference>
    <dbReference type="GeneID" id="56529381"/>
    <dbReference type="KEGG" id="bps:BPSL1681"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3761"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVTAEVT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="52"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="461" mass="50004" checksum="B05FD615E2A2AB30" modified="2004-10-25" version="1">MSDFEQVVRGRLVDAQQIVEDGWLAIRGGRIAARGAGAPPAARDLIDARGQWVLPGVVDGQVHAGSQANHEGLGRASRAAAAGGVTVMVDMPYDDPEPVASRAQLDRKIAEAERDCHVDIALYGTLNAKHGLDAAAGLIDGGVCAFKFSMFEATPGRFPRVDEDVLYDAFRLVAPSGLACGVHNQMQDLTRKNIARMIEAGDTGWDAFLRAHPPLIENLATALIYEIGAETGARAHAVHVSTSRGFELCNMFRRAGHHASIETCVQYLMLDHETHTKRFGAKTKHYPPIRPRAEQELLWTHVARGECTFVSSDHVSWELKRKGDANVFRNASGGPGLETLLPAFWTGCEQHGIAPTRVAELLATNPARHFLLDDRKGSLDVGADADFVILTPERYAFDPSCSLSAVQWSAFEGMEFAVRIAATYCRGALVYDGARIVNPAGSGRFLKPHGSRPIVTQPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UD7</accession>
    <name>Q63UD7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name evidence="3" type="ordered locus">BPSL1668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108279.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1668"/>
    <dbReference type="EnsemblBacteria" id="CAH35666">
        <property type="protein sequence ID" value="CAH35666"/>
        <property type="gene ID" value="BPSL1668"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1668"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1882"/>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="283" mass="31456" checksum="9875828BFB260764" modified="2004-10-25" version="1">MVRAALVTALPGFRLRRGDVHQIEDDGHDLDVAPRCRFYSSRREVPIDGCHKVQNIAVAAALDGGQAPPSAHGAGQFTDRKLMDKLHAERNVEWQTTSVSRRDRESRQAHGALAVWLTGLPGAGKSTLAIEAERCLHQAGKRTYVLDGDNLRHGLCRDLGFSADDRAENIRRAGEVARLFVDAGVIVLSAFISPFRFDRAKVRALFDAGDFIEVYCDCDPRICEIRDVKGLYRRARAGLISEFTGISSPYEPPRHPDVYVNTGKESLDACVDRIVRRVLHSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UH2</accession>
    <name>Q63UH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550398.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108244.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35629">
        <property type="protein sequence ID" value="CAH35629"/>
        <property type="gene ID" value="BPSL1630"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1630"/>
    <dbReference type="OMA" id="MYPEGAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="9107" checksum="803D429265C4CD66" modified="2004-10-25" version="1">MVGCAAMPQDIPEERPSLMEGRMPKPYLAMQMDAGCGDTPHANARAVCIEPAGSSFRSIEMYPEGAARYLDDQNRWFGADVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V56</accession>
    <name>Q63V56_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tox-REase-5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108010.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1386"/>
    <dbReference type="EnsemblBacteria" id="CAH35387">
        <property type="protein sequence ID" value="CAH35387"/>
        <property type="gene ID" value="BPSL1386"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1386"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.89"/>
    <dbReference type="eggNOG" id="ENOG50332ZH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FQTERTW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028904">
        <property type="entry name" value="Tox-REase-5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15648">
        <property type="entry name" value="Tox-REase-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tox-REase-5" evidence="2">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="168" mass="18955" checksum="4F75F62D831A90BC" modified="2004-10-25" version="1">MAGTASLSGDTPKEDSKATPDVRALPRTGESCKKCPPESGAKIRRNHGVNWNAYRYQARITGFAFDTEECRWSDEWNWLGIDFDGFQPGECLLQETKGNYDQFLDGSIPKADKFFKGFDSMEATAIRQSAAVRANPPARLMWYFQTPLARQRMLTVLRRLGITSILQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VM5</accession>
    <name>NUOI_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoI</name>
        <name type="ordered locus">BPSL1219</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186558.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107841.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VM5"/>
    <dbReference type="SMR" id="Q63VM5"/>
    <dbReference type="STRING" id="272560.BPSL1219"/>
    <dbReference type="EnsemblBacteria" id="CAH35214">
        <property type="protein sequence ID" value="CAH35214"/>
        <property type="gene ID" value="BPSL1219"/>
    </dbReference>
    <dbReference type="GeneID" id="56595153"/>
    <dbReference type="KEGG" id="bps:BPSL1219"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.307"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGDLYYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000250889" description="NADH-quinone oxidoreductase subunit I">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <sequence length="162" mass="18706" checksum="336BE74BCEA65B89" modified="2004-10-25" version="1">MTAIQQFFKTFFLTELLKGLALTGRYTFKRKFTVQFPEEKTPISPRFRGLHALRRYENGEERCIACKLCEAVCPALAITIESETRADNTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQILEYHGEKRGDLYFTKDMLLAVGDRYEKEIAAAKAADARYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VS3</accession>
    <name>KDPA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdpA</name>
        <name type="ordered locus">BPSL1171</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550718.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107793.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VS3"/>
    <dbReference type="SMR" id="Q63VS3"/>
    <dbReference type="STRING" id="272560.BPSL1171"/>
    <dbReference type="EnsemblBacteria" id="CAH35166">
        <property type="protein sequence ID" value="CAH35166"/>
        <property type="gene ID" value="BPSL1171"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1171"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.363"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000166488" description="Potassium-transporting ATPase potassium-binding subunit">
        <location>
            <begin position="1"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <sequence length="602" mass="62888" checksum="7E090CCDD8466E56" modified="2004-10-25" version="1">MNANNLLQAAIFIVVLIAAAVPVARYLTRVMDGSSAVVRVFGPLERALYRFAGIDPRTEMSWKQYALATVAFNALGVLFLYALLRVQGWLPGNPQGFGPMTVDGALNTAVSFVTNTNWQDYTPEQTVSYLAQMLGLTVQNFLSAATGIVVVLALIRGFARHTAQTIGNFWVDVTRVTLYVLVPMAAIIAALLMSQGVIQNTKAYQDVPTLQTTSYAAPRLDAQGNPVKDAKGNPVTVQTSVKAQTLAMGPVASQEAIKMLGTNGGGFFNGNSSHPYENPTPFSNFLEIFAILIIPAALCLVFGNTIGDRRQGVAVLAAMTVALAAAIGIETSAEQGGTPVLASLNVDLAASPLQAGGNMEGKETRFGIAQTGLFVVATTAASCGAVDAMHDSLTPVGGLVPMLLMQLGEVIFGGVGSGLYGMLVFALLAVFVAGLMIGRTPEYVGKKIESYEMKMVSIVVLLTPLLVLVGTSIAVLADAGRAGIANPGPHGFSEILYAFSSAANNNGSAFGGLSVNTPFYNWMTAIAMWFGRFGTIVPVLAIAGSLAAKKRIAATSGTLPTHGPLFVVLLLGTVLLVGALTYMPALALGPGVEHLMLFVGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VT7</accession>
    <name>Q63VT7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936882.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107779.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1157"/>
    <dbReference type="EnsemblBacteria" id="CAH35152">
        <property type="protein sequence ID" value="CAH35152"/>
        <property type="gene ID" value="BPSL1157"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1157"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1275"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHIPASK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="413" mass="46764" checksum="5490434A40E39BE8" modified="2004-10-25" version="1">MRVAKRQTNLLSDIELKHLARAGSPVAKSDGAGLTFTLSAAGTATWVLRFSHGGRRHELTLGNYPDLTLTAARKLAAAKRVEVQQGINPAVERRKEKARKDWSVRQLIADYRERVLVTLADSTQRSYGRNLVRVERGMGSLSVRVVSAADVVAEIERTKLGWVEAFTLWCVLKAIFKHAAGKRLIDANPCAGIMLEAIIGKRPPVRQRLMLTHEELYVLMNASMRDVNLYAVRIALATGVRISELYTSLRANLHLDEARWHIPASKTGPTMDIPLAPIVSEWFERLLDLAGTSEYVLPARLSNRLGRHDGDTHVSKDAIREAIDYWIDNHKPQIRRFTPHDLRSTMKSHMRRLGVSRDISEMCLNHKLAGVEGIYDQYTYWDERKAALDLWAAYLATRMRNEEWNVTPMKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU3</accession>
    <name>Q63VU3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936873.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107773.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1152"/>
    <dbReference type="EnsemblBacteria" id="CAH35146">
        <property type="protein sequence ID" value="CAH35146"/>
        <property type="gene ID" value="BPSL1152"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1152"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1269"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="74" mass="8152" checksum="AB4B90D69E09B194" modified="2004-10-25" version="1">MRRCRVAKFLLDGQALDDLANKLQQLQELFGVIQSENSITMRACVKCDIGSDIAERAAIELGELRSVSRAEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W60</accession>
    <name>Q63W60_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histidine transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisP</name>
        <name evidence="10" type="ordered locus">BPSL1030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553879.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107656.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1030"/>
    <dbReference type="EnsemblBacteria" id="CAH35025">
        <property type="protein sequence ID" value="CAH35025"/>
        <property type="gene ID" value="BPSL1030"/>
    </dbReference>
    <dbReference type="GeneID" id="56596160"/>
    <dbReference type="KEGG" id="bps:BPSL1030"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1118"/>
    <dbReference type="eggNOG" id="COG4598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NITMAPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="28870" checksum="FE52A592EE2C2288" modified="2004-10-25" version="1">MNTQMHKLFVDDLHKRYGNNEVLKGVSLRANAGDVISVIGSSGSGKSTMLRCINFLEQPNAGRIFVDGEEVRTAQDRTGALKAADSKQLRRVRTKLAMVFQHFNLWAHMNVLENVMEAPVHVLGITKREAQERAREYLEKVGLAPRVETQYPSHLSGGQQQRVAIARALAMHPDVMLFDEPTSALDPELVGEVLKVMQKLAEEGRTMIVVTHEMGFARNVSNHVMFLHQGRVEEEGAPADVFGATKSERLRQFLSGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W64</accession>
    <name>Q63W64_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">BPSL1026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107652.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63W64"/>
    <dbReference type="STRING" id="272560.BPSL1026"/>
    <dbReference type="EnsemblBacteria" id="CAH35021">
        <property type="protein sequence ID" value="CAH35021"/>
        <property type="gene ID" value="BPSL1026"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1026"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1114"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="576" mass="61505" checksum="D2C766714B3D56F4" modified="2004-10-25" version="1">MARGGRADPVMKTRIALAQLNVTVGDFAGNVAKIVAAAQAAHDAGAHLLIAPELALSGYPPEDLLLRPAFYAASDAALAALAAQLKPLAGLAVLVGHPLRAAGAGASSADGNANRPIERGAAPVDTYNAASLIVGGEVVGTYRKQDLPNTEVFDEKRYFATDAAPYVFELNGVRFGVVICEDVWHASAAQLAKAAGAQVLIVPNGSPYHMNKEAVRIDILRARIRETGLPMVYVNLVGGQDELVFDGGSFVLDGAGELVAKMPQFEEGHAIVEFDGARALPAPIAPALPVEAQVYRALVLGVRDYIGKNGFPGAIVGLSGGVDSALVLAVAVDALGAERVRAVMMPSRYTADISTTDAADMAKRVGVRYDEIAIAPMFDAFRASLAAEFAGLAEDATEENIQARIRGTLLMALSNKFGSIVLTTGNKSEMAVGYCTLYGDMAGGFAVIKDIAKTLVYRLCRYRNAAAEYGALDVIPERILTRAPSAELRENQTDQDSLPPYDVLDAIMRMYMEEDRPLAEIVAAGYAEADVKRVTRLIKINEYKRRQAPVGIRVTHRAFGRDWRYPITSRFIESID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WU0</accession>
    <name>Q63WU0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ordered locus">BPSL0801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522681.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107426.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0801"/>
    <dbReference type="EnsemblBacteria" id="CAH34793">
        <property type="protein sequence ID" value="CAH34793"/>
        <property type="gene ID" value="BPSL0801"/>
    </dbReference>
    <dbReference type="GeneID" id="56527020"/>
    <dbReference type="KEGG" id="bps:BPSL0801"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.803"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="117"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="161"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="398" mass="41597" checksum="08126DD478593269" modified="2004-10-25" version="1">MTALPTPNSPILPGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDPTSPAGAVADKHLRAAYDDEAALAELAQLCDAVSTEFENVPAASLELLAQSTFVAPAGRCVAIAQDRIAEKRFIAASGVPVAPHVVIESHAQLAALADADLAAVLPGILKTARLGYDGKGQVRVATVREARDAYASLGGVPCVLEKRLPLEYEVSALIARGANGASAVFPLAQNTHHGGILSLSVVPAPAASDALVREAQQAAVRIADSLGYVGVLCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACETSQFEQQVRAMTRLPLGSTRQHSPAAMLNVLGDVWFANGVSGEPVTPPWDEVAAMPTARLHLYGKEEARAGRKMGHVNFTAATRDEAVAGATACARLLRIALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WU1</accession>
    <name>Q63WU1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ordered locus">BPSL0800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188932.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107425.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0800"/>
    <dbReference type="EnsemblBacteria" id="CAH34792">
        <property type="protein sequence ID" value="CAH34792"/>
        <property type="gene ID" value="BPSL0800"/>
    </dbReference>
    <dbReference type="GeneID" id="56596565"/>
    <dbReference type="KEGG" id="bps:BPSL0800"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.804"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="13"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="18000" checksum="C967E66244B39147" modified="2004-10-25" version="1">MSEVQTAHTHSAPLVGVLMGSSSDWDVMKHAVAILQEFDVPYEARVVSAHRMPDEMFDYAQQARERGLRAIIAGAGGAAHLPGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVATFAIGEAGAANAALFAVSILSGTSADYANRLAAFRVRQNEAAHAMALPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XD9</accession>
    <name>Q63XD9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204838.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107226.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0597"/>
    <dbReference type="EnsemblBacteria" id="CAH34590">
        <property type="protein sequence ID" value="CAH34590"/>
        <property type="gene ID" value="BPSL0597"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0597"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1034"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYPRAHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023889">
        <property type="entry name" value="TOMM_kin_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03903">
        <property type="entry name" value="TOMM_kin_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1330"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1359" mass="145131" checksum="4D7036EE41312757" modified="2004-10-25" version="1">MSASVLAERARAGNRRAPRALAPPLPGDGDELQGEHRYRLGAVLGEGGAGRVHEAIRLDTSARVAIKLLREDAPRGARERARLRARFRRETALCARLSHPHIVALLDSGETPDGLLFAVFEHVAGRTLRALLAADGALAAETTGALMAQVLDGLAHAHANGVVHRDLKPQNVMVTTRDGEPCAKILDFGIGALLPDAHAADELTLTATTEVLGSPQYCAPEQLRGEPPTAKSDFYAWGLIVIECLTGHPVMQGASLADVLYQHLSPVDVALPPAIAAHPLGDVLRDALNKDPRQRAESAQALANRFRAIHFPALVGGLRYGARHGRRAQAEPGVAAREPGGTIALDAPVGRRQVTALCCRVSVVSTLARPADAAADDEALDAFHAHWLTRCSDIAVRYGGHVAGALGDTLLFYFGYPEGIDRPAQRACRAALEMTRHAGQPAGAPRSSDGDARACAPAWRIDIAGAIHVGTAFATARGASGGVLASAALGLQRIAQPGGILLSDEAARALERHVDAAPTALTFAAPGAAPQPVRELLGERYERGPFESLELGDATPIVGRDREQAALARAWRDAVRAAAGGRRARRRATLVVGEPGIGKSRLVHALRELVRAQRGACAACVCLPEQTNHALFPILRFVRAHWQLDVGDPHALDRMLEAFDGDRASARATLAAWLGLPGGADTLRWSGARQQQALFDVLCQLLGSLGGGGPVLLIVDDVQWCDSATDDFLDALAHHPACAAVCVVLTSRPERLERWRRGAERLMLRRLSAAATRNLIVSLMPGAGTQRAALDFLVKRTGGVPLYVEETVRALAEGGVAPGAGARLPDLAQAGRCPLPGSLRETLELALERADDALDTVQLAATIGLEVDARLLAEASPHAGAELDERLRRLIEGRVLYAQHRIGGATYVFRHALLREAAYESMPAATRREYHRRVAQALLACVAQGDPAARSASIADHFARAHAFAAAVPHGIEAARRALARALHDDAIRYAGAVRGWLLHCDYPGQHEDAVSVDLTLAHAQMARDGWGDPRVREHTDRVLSRVGELSDAKAAAGALWTIAVYHHVAGDRDAVRRIGGQLSALARASARADLGVAADTLHGMALWIDGHYTLALDAFDAALAAYDPRRDGDHRHVFGLDTRAWAQSARACVLWGIDDDVARTLALARDAVQLATCTDHLPTIGLTMMYLARMQQCVGDREGARATADAVLRLSRCHGLNAVERYAAVVRAWCDGDRDAARANVDALRASGCMLGLTYYASVAADIDAERGDARAALATLDECLALAESMDERHYVAELLLKKARCVRDAHGRRAADDAQALCARAAAVARRSGMARIERKAQAELRELQRELRSTTGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP1</accession>
    <name>Q63XP1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphotransferase system, IIbc component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BPSL0499</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107124.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0499"/>
    <dbReference type="EnsemblBacteria" id="CAH34488">
        <property type="protein sequence ID" value="CAH34488"/>
        <property type="gene ID" value="BPSL0499"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0499"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.557"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVHCARP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019866">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
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        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="TIGRFAMs" id="TIGR01998">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="7"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="398"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH34488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="590" mass="61370" checksum="6FBCFAE7A0BE05EE" modified="2004-10-25" version="1">MEDRMDGNPFLKIQSLGRALMLPIAVLPVAGILLRLGQQDVLNIKMIADAGGAIFENLPLLFAIGVAVGFAKDNNGVAALAGAIGYLIEVAIMKDIDPKLNMGVLSGIIAGVVAGLLYNRYKDIKLPDYLAFFGGKRFVPIITGLACVVLGIVFGYVWQPVQHAIDAVGQWLLTAGAIGTFVYGFLNRLLLVTGLHHIINSLVWFVFGTFTPAGGAAVTGDLHRFFAGDPSAGGFMAGFFPIMMFGLPAACLAMFHEAPKARRAIVGGLLFSMALTSFLTGVTEPIEFSFMFLAPVLYVIHAVLTGLSLAICQLLGVKLGFTFSAGAIDYVLNYGLSTKGWIAIPLGLAYGLAYYGLFRFFIRKFNMATPGREPAGADAQAQSFASGGFVAPTAGASVPRAQRYIAALGGAANLSVVDACTTRLRLSVVDPEKVSEADLRTIGARGVLKRGGSSVQVIIGPEADLIADEIRATLGSGAAAPAAAAAAAPAAAATAAGAQSGPLDPEPTRWLAVFGGATNVASLDAVAATRLRVVVRDPSAVDRQRLATLDVAWVASDTFHIVCGQSAPRYAQQLAARLPSSDGGTAAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y48</accession>
    <name>Q63Y48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522988.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106967.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0340"/>
    <dbReference type="EnsemblBacteria" id="CAH34329">
        <property type="protein sequence ID" value="CAH34329"/>
        <property type="gene ID" value="BPSL0340"/>
    </dbReference>
    <dbReference type="GeneID" id="56527416"/>
    <dbReference type="KEGG" id="bps:BPSL0340"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1340"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="17266" checksum="9F7148714E949331" modified="2004-10-25" version="1">MKLDSIDRRILRALQRDGRQQNVELAKEVGLSPSPCLRRVRLLEEAGVIERYVAVLNPAKVGRGLTVFTRVWLKEQDADTVAHFAEAVQHLPQVVECHLMAGDCDFLLRVVAADIDDYRQFQMQHLTRIRGVQSVKTEIPLQKVKLTSEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y86</accession>
    <name>Q63Y86_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cation transporting P-type ATPase</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">silP</name>
        <name evidence="9" type="ordered locus">BPSL0302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106929.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0302"/>
    <dbReference type="EnsemblBacteria" id="CAH34291">
        <property type="protein sequence ID" value="CAH34291"/>
        <property type="gene ID" value="BPSL0302"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0302"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1388"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACGMNMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="8">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="807" mass="84887" checksum="2A767814E2736607" modified="2004-10-25" version="1">MHDAHVHHDHSGDTNERRDPHRPHETKTPGETAVDPVCGMKVPIDTPRRYDYQGRTYRFCSDKCATAFRASPQRFVGTPKQRAGASAAKPGTVYTCPMHPQIRANAPGACPICGMALEPLTPDAAEDGNPELRSMTRRFQLGLVLAVLLVLMTMGAMVLPFDIGAGIDALLARWPRPFGMPASWSQWVQAALATPVVLWGGWPFLVRGWKSFVTRRLNMFSLIGLGVCVAYLFSVFALLFPDTLPQAFRSGHEIPLYFEASAVIVTLVLLGQVLELRARSRTSSAIRDLLQLAPHTAVRVNPDGSEQTVPLDAVVVGDTLRVKPGSKVPVDGIVVAGHSSVDESMITGEPVPAEKTEGSPVTGATVNQTGTFVMRAQKIGTDTLLARIVQMVAEAGRSRAPIQKLADQVSGGFVLTVIVLAALAFAAWAAFGPAPALANALVVAISVLIIACPCALGLATPVSIIVGVGRGAREGVLIKDAEALELMEKVDTVVVDKTGTLTEGRPRVQTIVALGGQSERALLGDAASLEGASEHPLAQAIVEHAARMGAERKPVASFDSVPGKGVKGTLDARTVALGNAHLMADLAIDCTAADADSNRLREAGQTVMYVAIDGRLAGYIGVADPIKETTPDAVQLLKASGTRIVMLTGDNPVTANAVARTLSLDGVKAGVLPEDKYRHVQALQQQGHVVAMAGDGVNDAPALAQANVGIAMGTGTDVAMNSARIVLVKGDLRGIARARALSVATMKNIRQNLFFAFVYNAVGIPVAAGVLYPWFGITLSPIFASAAMAASSVSVIGNALRLRGAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC9</accession>
    <name>Q63YC9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AHS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266314.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106886.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0259"/>
    <dbReference type="EnsemblBacteria" id="CAH34247">
        <property type="protein sequence ID" value="CAH34247"/>
        <property type="gene ID" value="BPSL0259"/>
    </dbReference>
    <dbReference type="GeneID" id="56594390"/>
    <dbReference type="KEGG" id="bps:BPSL0259"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1449"/>
    <dbReference type="eggNOG" id="COG2049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPGFAYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="22984" checksum="57DBBE5DAE6D5583" modified="2004-10-25" version="1">MTTPRIYPLGDTALVCEAPPPATLECQRRVWAVASAAAGWPHVVDVVPGMNNLTIVFDPLETTADTLAPLMKAAWRDADGVAESGREIEIPVEYGGAFGPDLDAVARHTGLARDEVVRRHAAGTYVVFFLGFQPGFTYMGGLDGSLHTPRRAAPRLEVPAGSVGIGGEQTGIYPAAAPGGWQLIGRTPLALFDPARTPPTLLQPGDRVRFIVAGVHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YI2</accession>
    <name>Q63YI2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase-binding transcription factor DksA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dksA</name>
        <name evidence="8" type="ordered locus">BPSL0205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts directly with the RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DksA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198318.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106833.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0205"/>
    <dbReference type="EnsemblBacteria" id="CAH34192">
        <property type="protein sequence ID" value="CAH34192"/>
        <property type="gene ID" value="BPSL0205"/>
    </dbReference>
    <dbReference type="GeneID" id="56594448"/>
    <dbReference type="GeneID" id="66548600"/>
    <dbReference type="KEGG" id="bps:BPSL0205"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.218"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KKGEEYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00926">
        <property type="entry name" value="DksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012784">
        <property type="entry name" value="DksA_RNA_pol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02420">
        <property type="entry name" value="dksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="138" mass="16010" checksum="C33B4690F8C2595B" modified="2004-10-25" version="1">MTKKLLTEAEILKMSDKDYMNEDQLAFFKNRLEQLQAEILRNAGQTTENLRETVIVPDPADRATIEEEHALELRTRDRERKLLKKVQQSLARIESGDYGWCEETGEPIGIPRLLARPTATLSLEAQERRELRQKLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YP8</accession>
    <name>Q63YP8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549900.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106767.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0139"/>
    <dbReference type="EnsemblBacteria" id="CAH34126">
        <property type="protein sequence ID" value="CAH34126"/>
        <property type="gene ID" value="BPSL0139"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0139"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.154"/>
    <dbReference type="eggNOG" id="ENOG5032X7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALGWDDS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="98" mass="10522" checksum="08BEBA3F5CA36E93" modified="2004-10-25" version="1">MRNPALIEPALRHALHGPKRQDVQQALGWDDSQVSRFLSGGQGVVIDKIDTLVAAVGFVLVTRKYLDAVATLGEVGVHCECARRGYGECRPGSSSCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YU7</accession>
    <name>Q63YU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106718.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0092"/>
    <dbReference type="EnsemblBacteria" id="CAH34076">
        <property type="protein sequence ID" value="CAH34076"/>
        <property type="gene ID" value="BPSL0092"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0092"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.103"/>
    <dbReference type="eggNOG" id="COG4461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLVMMRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266438" evidence="2">
        <location>
            <begin position="18"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="31944" checksum="2E74F1A9F45F39C1" modified="2004-10-25" version="1">MRIFVLPCLSAAMLVSACNHSSKPETSAVATSAPQHASTSAAGSANTPAALPVPAAMPAPPPHQYAMEQDGTYGYEPALSEDDVRSGKATKPLVMMRYVGRRDGTYVLLLIDPDNENYATRVTCQAPCNFAKLQTMSGTMVLKTETIRVAPNSLIGAMLDDALSGQLRPYGQTVTMPRPTAVPSTAQPADQSAPQDSSPQSDLQRTSFDCSKVGSIPEYLICHDPELAASDRELANIYQQAKDAVPDKAAFAARTRRQWNFRQRNCRDKPCLVSWYAYQKETLTKIAQTGDVNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YY4</accession>
    <name>Q63YY4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR-like family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525795.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106681.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34039">
        <property type="protein sequence ID" value="CAH34039"/>
        <property type="gene ID" value="BPSL0056"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0056"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1687"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRWEEST"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="12827" checksum="6DD9F9C1B017F717" modified="2004-10-25" version="1">MKTQLKKGALDMCVLAMLARRDSYAYELVSTLAETMEISEGTIYPLMRRLQAEAWVTTYLVESTSGPPRKYYSITDAGRASLRQMEDEWRSFVDEVNGVLALHGTRADGEERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z16</accession>
    <name>Q63Z16_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106646.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0021"/>
    <dbReference type="EnsemblBacteria" id="CAH34004">
        <property type="protein sequence ID" value="CAH34004"/>
        <property type="gene ID" value="BPSL0021"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0021"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1726"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MEPHGIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17966" checksum="02122E84475F7E87" modified="2004-10-25" version="1">MSGLYDPEHIELESSLGYYLTKARQALVERLDRALGPLELTAQQISVILLLARGYARTPFELSRKLSYDSGSMTRMLDRLEKKGFVVRARSESDRRVIELALTERGAHAARALPALIATELNAQLEGFSADELALLTDLLRRFIANAPGAADAACAEPPPDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>H7C758</accession>
    <name>H7C758_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530752.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110458.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0435"/>
    <dbReference type="EnsemblBacteria" id="CAH37891">
        <property type="protein sequence ID" value="CAH37891"/>
        <property type="gene ID" value="BPSS0435"/>
    </dbReference>
    <dbReference type="GeneID" id="56531116"/>
    <dbReference type="KEGG" id="bps:BPSS0435"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6574"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRWLLKM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="207"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="308" mass="32750" checksum="875D7BA8109E3C2A" modified="2012-04-18" version="1">MNCTDLAPTSLREAFRGATIETIDARVEGHASVVLTRVRHAAHGFGFVEFMPPADGYLVGMSLTPPAARAPRAAPDAAADADGDADAPHRAACVAVQILQDDEPFRADLLQPFDMLFHALPRRTLAELAADLRMGGVRELASPAGGRDAVLQSLVGVLLAASAGSSARSPLLAGHVARAMQIHIVQQYGVAAPSTPAKGGLAGWQLERAKAILTENIAGEVPISQVASACGLSRSYFIKAFRQTVGTTPHRWLLEHKIERVKRSLLSQSAPIADIAHQCGFSDQAHLTRVFTSMIGTPPAAWRRVNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HS2</accession>
    <name>Q63HS2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS2347a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194479.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112350.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2347a"/>
    <dbReference type="EnsemblBacteria" id="CAH39834">
        <property type="protein sequence ID" value="CAH39834"/>
        <property type="gene ID" value="BPSS2347a"/>
    </dbReference>
    <dbReference type="GeneID" id="56598463"/>
    <dbReference type="KEGG" id="bps:BPSS2347a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5989"/>
    <dbReference type="eggNOG" id="COG5660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACDACTR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="65" mass="7450" checksum="0E564BB1A2F3C46F" modified="2004-10-25" version="1">MLLGKCKDITRLLSDELDRPLSLDERLRVRVHLPACTGCRNYRMQIRMLREAARVAGGNNGPRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HT8</accession>
    <name>Q63HT8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112334.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2332"/>
    <dbReference type="EnsemblBacteria" id="CAH39818">
        <property type="protein sequence ID" value="CAH39818"/>
        <property type="gene ID" value="BPSS2332"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2332"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6791"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLGWIHS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="182" mass="19949" checksum="0A32E771AF6025F8" modified="2004-10-25" version="1">MRLPEFNRDTATDEQKAVLDEILSGPRGNLNGPFLGWIESPALAQHAQRLGAFCRYRTGLPPRLSELAILVTAARWRSQAEWHIHHPIALEAGVPAAAAEAIRTGAAPSFDDADDALIFRFATELYETKRVSDATYDAAVARFGHRVVVNLVALLGYYALVAMTLNVFDMRADGQTALPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I39</accession>
    <name>Q63I39_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523328.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112233.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39716">
        <property type="protein sequence ID" value="CAH39716"/>
        <property type="gene ID" value="BPSS2230"/>
    </dbReference>
    <dbReference type="GeneID" id="56531679"/>
    <dbReference type="KEGG" id="bps:BPSS2230"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5827"/>
    <dbReference type="eggNOG" id="COG1873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GTIDHIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17464" checksum="C3EC982BFA94EAF5" modified="2004-10-25" version="1">MNTPQQGTTRIIGKGRASAAGPGPDVMAASTLDGDKVYTTDGDDVGKIKEIMLDVRTGRVAYAVLSSGGLLGIGDKLLAIPWSALTLDTDRKCFLVAVSSERIKNAPGFDKSHWPTMADPNWAASLHQYYGSAPYWSDIEEELGIDAPPHEASPDRPERGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IB6</accession>
    <name>Q63IB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552222.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112156.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2155"/>
    <dbReference type="EnsemblBacteria" id="CAH39639">
        <property type="protein sequence ID" value="CAH39639"/>
        <property type="gene ID" value="BPSS2155"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2155"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5727"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSWWLVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="487" mass="51783" checksum="E2F6F509629CDB0C" modified="2004-10-25" version="1">MSDVQAASLAARIDRLPATATIWKLVWVLSIGGFFEVYDLFQMTYLPAGMVRDGIFHAGARGAFGISDQGALGAATFAGLFIGEMFVSRLADRFGRRALFTGSLLLYTAASVAMCVQSSALGVLVCRFVASCGVGAELITIGAFLSELVPKAVRGRAFAVCFAIGYLAMPVLAFVSWLWVPHAPLGLSGWRWVVLLGGSGAVAVWWLQSRLPESPRWLAERGRVAEADAILRRLEACVERETGRPLPPVPPPVDAPRHAIAPSRRASMWDADNRGRTAMLIVFNAFLSIGFFGFSQWLPTLLAAQGASVTKSLWYAFVIAFAYPVSPFAAAALADRIERKWLIVAAAFGVALFGTGFAMSAHPAAVIAFGILVTLCNTVLASNATAYQSEVFPTRIRGRALGFVHSIGRLTGIASSFVVALLIEHVGVPSVFVLIGASMAIVMLSIGMFGPRTNNRSLEDIVARASESGAATGARRAAPGEARRSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE9</accession>
    <name>Q63IE9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530154.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112123.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2124"/>
    <dbReference type="EnsemblBacteria" id="CAH39605">
        <property type="protein sequence ID" value="CAH39605"/>
        <property type="gene ID" value="BPSS2124"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2124"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5676"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWEFYLE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="307" mass="32552" checksum="FC3E31DE56FD1299" modified="2004-10-25" version="1">MNPSDLRDLRLPSLDGLLAFVAAARHGTFERAAEELCVTGSAVAKRVAALEQLLGVQLLVRSGKALTLTAAGNEYLHQVHAPLHLLAAVPLHRRNAGKTERLRICAPPTFARQILVARLDAFTLAHPGVELEVMLASPFPDAPPTGADLWIRGGGPIVSGATVLMVDALTPLAAPSLVERFAPLRRPADLAALPLLCTPLEPWTPWFRVAGLDWPEPANGPKLLDLGLLLEAAVSGQGVALGSPALARPWLAAGALVPLFPRIVRPAAPYYLMPYAPRAAAGAFAAWLAEVCERAVRDGAEFLSRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF0</accession>
    <name>Q63IF0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190661.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112122.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2123"/>
    <dbReference type="EnsemblBacteria" id="CAH39604">
        <property type="protein sequence ID" value="CAH39604"/>
        <property type="gene ID" value="BPSS2123"/>
    </dbReference>
    <dbReference type="GeneID" id="56598146"/>
    <dbReference type="KEGG" id="bps:BPSS2123"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6514"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQVGPSC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="444" mass="47717" checksum="B0D29FBC21C0B15D" modified="2004-10-25" version="1">MPTPTPGTPRPPRTPQPVRAALAAFIGTTVEFYDYYTYATAAALVLGDVFFPSDNPFVSTMASFATFFVGFVARPLSGAVFGHLGDRIGRKKMLVLTMFLMGAATTGIGLLPGYATIGVWAPVLLVLLRILQGIAVGGEWGGAVLMASEHASAGRRTLFASFPQMGSPAGLILSLLAFRYVTSLDHARFVAWGWRLPFLASFVLLLIGVAVRLGVNESPEFERVRDSHAVARFPVAEVLRTAWYPIVLAAAATTIGSAGFFFTNTFMISYVTTYLGMSKSFILDCLFAVTLIQLLSQPVSALLAQRFGETRFLVCAALLSMLTPYPMFVLVRTHDPVAIVAGIAFAVVALSAVYAVIAGFMSAAFPTRVRYSGISIAYQLCALVAGGTTPLVGTMIAQRYRGEWLPLALFFSLLAFVSLVGIVGLGRYRRNLHAVAPRTWAVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IP3</accession>
    <name>Q63IP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205720.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112029.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2026"/>
    <dbReference type="EnsemblBacteria" id="CAH39504">
        <property type="protein sequence ID" value="CAH39504"/>
        <property type="gene ID" value="BPSS2026"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2026"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5552"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AAYQKKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="270"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="537" mass="57733" checksum="99D8BFBB1285A6B6" modified="2004-10-25" version="1">MTEPCVLAIDLGTSGPKAAVVSLDGRVVAAARDAVATLRMPDGGVEQDPLAVWRAVKRACGGALRAAGIASRDVLAVACASQYSSIVPVGADGAPVANMMLWLDRRGAPRARRGAADGPLRADSPLRQWRWLRVHGLPPVEGGISLTHMRYLKHAKPDVYARTATFLEPMDYLNLCFTGRACANQCTAFMSLVVDNRRLNVACYDPRLVRYSRIDASKLPELLPVDAIVGRVLPDVADELGLPRGTPVVAGLNDTQAGGIGAHAFAGEHAALSIGSSSVMIAHVRFKRTDIRHAILSMPSPIPDTYFVMAENGIGGAALKHFIEQQVYADDPFGALPRDDCFARLQKAIDATPPGSGGVMFMPWLAGSLAPHADASMRGGFVNLGLDATRSHLARAVLEGVAMNLRWLRGPVEAFAKRRFSHFVFYGGGAESDAWSQIVADVLDAPVHRIEQPQYTTCVGVALLAFQRLGLLGFDDFASRVRIRGVCEPNCANARVYAEMSAQFVEAFRRNRPIFRALQRNLRRPASAAANGLRPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IY8</accession>
    <name>Q63IY8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544739.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111934.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39406">
        <property type="protein sequence ID" value="CAH39406"/>
        <property type="gene ID" value="BPSS1928"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1928"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5414"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYWHPNF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="101"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="30771" checksum="043A01047740664C" modified="2004-10-25" version="1">MSFRSRFTWRTAVFGPGFRPVSRIVATTASSGAPAVAAPPTDVAVLVYHRFSNVCGADPMTVGVATFEAQLAHLRRLGYRFVPLRDVIGWLRGEPVALPSKAIALTIDEGHASIFDWARTIALRERVPITLFVYPSAIGEAPGALTWHQLRVLHKTGWFDVQSHAWWHPDLNAAHRPPSGAFREATRAQFAQARARIAREIGNQVDLLAWPFGAFDGELGAAAREAGYVAGFTLEPSKIRRDTPLLTLPRFLMVEECTPAVLRRLLSKSDAAREEAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IZ5</accession>
    <name>Q63IZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111927.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39399">
        <property type="protein sequence ID" value="CAH39399"/>
        <property type="gene ID" value="BPSS1921"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1921"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6274"/>
    <dbReference type="eggNOG" id="ENOG502ZQ6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMQIVYL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="11432" checksum="64C2F5BB358580A1" modified="2004-10-25" version="1">MSARGERPMGIGMQIAYFGFAGSAQLEAEASIQLIRLERFSARLAGCHLAIEALGAGAASPTYDVRLDLITRGYELKPIPHMTGTDPLDAIRRAFDAAERELAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IZ6</accession>
    <name>Q63IZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544572.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111926.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1920"/>
    <dbReference type="EnsemblBacteria" id="CAH39398">
        <property type="protein sequence ID" value="CAH39398"/>
        <property type="gene ID" value="BPSS1920"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1920"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6272"/>
    <dbReference type="eggNOG" id="ENOG50316N3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAILWLD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021947">
        <property type="entry name" value="DUF3564"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12087">
        <property type="entry name" value="DUF3564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="142" mass="15575" checksum="C595FC99C7D7C0CC" modified="2004-10-25" version="1">MGHQPIARHRRAFDKERAVRITVHLDTFASTDPAAYAILWIDTTEHRWSREGHAGVELPAWGNVVCRGGTTRVTGADDPHSLCVLEGLDLGAKQGPFEGETGAAHWYPHAHRAPVVGAWHVQCIDETVAPAEHELFTGREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JK3</accession>
    <name>Q63JK3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530342.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111719.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1713"/>
    <dbReference type="EnsemblBacteria" id="CAH39187">
        <property type="protein sequence ID" value="CAH39187"/>
        <property type="gene ID" value="BPSS1713"/>
    </dbReference>
    <dbReference type="GeneID" id="56529876"/>
    <dbReference type="KEGG" id="bps:BPSS1713"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5130"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGHFYDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="129" mass="14121" checksum="D5171EA270259557" modified="2004-10-25" version="1">MFSHVCMGVTDVERAFAFYAPLMEALRLDLKFRDPHGWTGWKPAGAPRPLFLIGRPFDGAPHAPGNGQMTAFLAADRATVDRVYALALRAGGASEGAPGLRPHYHPDYYGAYFRDLDGNKLCVCCHEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW8</accession>
    <name>Q63JW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative type IV pilus biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pilR</name>
        <name evidence="9" type="ordered locus">BPSS1596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187516.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111604.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1596"/>
    <dbReference type="EnsemblBacteria" id="CAH39071">
        <property type="protein sequence ID" value="CAH39071"/>
        <property type="gene ID" value="BPSS1596"/>
    </dbReference>
    <dbReference type="GeneID" id="56597948"/>
    <dbReference type="KEGG" id="bps:BPSS1596"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4977"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQFCADM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="223"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="358" mass="39228" checksum="1B937624B439E42B" modified="2004-10-25" version="1">MALELNRRWAKLCLNADERLRVYRKIAKMLGNGLPLLKVLEELEWRASREGRKPREPLAIVLSDWRLAVQNGGMLSEAMDAWVPATEQMIVAAGEQAGRIEDALASVADIVQSSRKIRRAVTGGVAYPVGLVVMVIGYLYLFGTHVIPKFALIADPAHWRGAARSLYLMSLFVQGWMLVVVAALAAALVALAWSLPRWRGPLRIYADRVPPYSIYRLIAGSGFLIAFSALQASGVTVEKALLKIGSVAGPWLRERIDDTLVGVKSGLNAGEALLNAGYQFPSREIVEDLCIYAEYGGFDAALKMLADEWLEEGVARITAQMRVLNGVAIVVLALLIGWLVTGFFGIQQEIAAMTRAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JX7</accession>
    <name>Q63JX7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ordered locus">BPSS1587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187785.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111595.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1587"/>
    <dbReference type="EnsemblBacteria" id="CAH39062">
        <property type="protein sequence ID" value="CAH39062"/>
        <property type="gene ID" value="BPSS1587"/>
    </dbReference>
    <dbReference type="GeneID" id="56597938"/>
    <dbReference type="KEGG" id="bps:BPSS1587"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4965"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="317" mass="34040" checksum="BEB889447D58B9D1" modified="2004-10-25" version="1">MSDDYFQPQSGNAMPRFAGIATMMRLPQAASAAGLDACFVGVPFDLGTSNRTGARFGPRQIRSESVLLRPYNMATRAAPFDSLRVADLGDVATNPYNLADSIARIEAAYHAILAHGCRPVTLGGDHTITLPILRAMHRRHGRVGLIHVDAHADVNDTMFGEKIAHGTPFRRALEEGLLDGDRVVQIGLRGTGYAAEDFDWCRDQGFRVVQAEACWNRSLAPLMDEVRARVQGGPVYLSFDIDGIDPAYAPGTGTPEIAGLTVPQGLEIVRGAWGLDIVGADLVEVAPPYDPFGTTALLGANLAYEMLCVLPGVARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K71</accession>
    <name>Q63K71_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two-component response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528788.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111501.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1494"/>
    <dbReference type="EnsemblBacteria" id="CAH38967">
        <property type="protein sequence ID" value="CAH38967"/>
        <property type="gene ID" value="BPSS1494"/>
    </dbReference>
    <dbReference type="GeneID" id="56530092"/>
    <dbReference type="KEGG" id="bps:BPSS1494"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4840"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EMGSDDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="27998" checksum="F2C95530078CE05E" modified="2004-10-25" version="1">MTNATRSPAVLVVEDDEPLRRVLCNYLSGHGMAVDGVGTAAAAAESVGRREYEMVLLDLGLPDGDGIDVLLRWRETQRFPLICVTGRSEEADRIMGLEFGADDYVVKPYSLREVLARMRALWRRAEPSTTPVRRGRHPRAYRFDGWTLNMNTRRLLTRDAQEIPLTVGEFNLLAFFLGSPSRVVTRAQLLECTRAFDDVFDRAVDVQIWRLRKKIEKDPKHPELIRTERGVGYYFDAKEVETLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KD2</accession>
    <name>Q63KD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198708.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111440.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1428"/>
    <dbReference type="EnsemblBacteria" id="CAH38903">
        <property type="protein sequence ID" value="CAH38903"/>
        <property type="gene ID" value="BPSS1428"/>
    </dbReference>
    <dbReference type="GeneID" id="60551097"/>
    <dbReference type="KEGG" id="bps:BPSS1428"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4755"/>
    <dbReference type="eggNOG" id="ENOG50316NK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRMWIDN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="71" mass="8025" checksum="F0E622A4FD11CFF0" modified="2004-10-25" version="1">MNRSIRYKGYEVAPAAARLPNGLFAANLTIEKAGPAPARAYSFDAIDFFFDEEHALAYAFRWGRLWVDSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KL6</accession>
    <name>Q63KL6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528650.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111355.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1345"/>
    <dbReference type="EnsemblBacteria" id="CAH38816">
        <property type="protein sequence ID" value="CAH38816"/>
        <property type="gene ID" value="BPSS1345"/>
    </dbReference>
    <dbReference type="GeneID" id="56530235"/>
    <dbReference type="KEGG" id="bps:BPSS1345"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5561"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KFVGHVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="16532" checksum="A31885171CFDF342" modified="2004-10-25" version="1">MTIELEARATHAVLDAAREAALAAGLPYAGGVSPRDAWALVAAGHARLVDVRTAEERTFVGHVPDSLHVPWATGTSLTRNPRFVRELEAKTGKDAVVLLLCRSGNRSALAAQAAAKAGFTQVFNVLEGFEGDLDDAGHRGTTNGWRLHGLPWRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ9</accession>
    <name>Q63KQ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase DmpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539564.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111312.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1303"/>
    <dbReference type="EnsemblBacteria" id="CAH38773">
        <property type="protein sequence ID" value="CAH38773"/>
        <property type="gene ID" value="BPSS1303"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1303"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4592"/>
    <dbReference type="eggNOG" id="COG3191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWGHGSG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="448" mass="45024" checksum="49852B9ADB07E91B" modified="2004-10-25" version="1">MRARTSGRADAAEALDAADAAPHVGALPAGPLRSIADVAGVTVGHATLDARGVQTGVSVVRPHAGDVYRDKVPAAAAVINGFGKSIGLVQVDELGVLETPLALTNTFGVGALAQAQIRAAIDANPQIGRAWPSVNPLVFECNDGYLNDLHAFAVTPAHYAQALADARRAFARGAVGAGRGMSCFDLKGGIGSASRVVRAAGEAWTVGALVLANFGRLPMLTIAGVPVGRMIAERDAGGAPGAGGGQGADGARDDVAAAGARGERGERGDGPHGTYGTYGTYGAHGRENAGTGGGAAGGLAPRRARDAGASSPGAAPDAAPPEQGSIIMLVATDAPLSSRQLKRVALRAAAGLARTGSVYGHGSGDIALAFSTAYTVPHDAERVSLPALVADAALDPLFAAAADSVEQAIVDALWRATRVTGRDGHTRRALRDAAPELERWLRAARAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KW2</accession>
    <name>Q63KW2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-carbamoyl-L-amino acid amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547538.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111259.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1251"/>
    <dbReference type="EnsemblBacteria" id="CAH38718">
        <property type="protein sequence ID" value="CAH38718"/>
        <property type="gene ID" value="BPSS1251"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1251"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4513"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IWPHGRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="459" mass="48442" checksum="BFC66F35900B8CF6" modified="2004-10-25" version="1">MWEIDGRRLWNSLTELARIGGTARGGVRRLALTEADRRGRERFAQWCRDAGMAVRVDAIGNLFARRAGADDTQPAVLVGSHLDTQPEGGRFDGAYGVLAGLELVRTLNDRGIVTGKPIEIVSWTNEEGARFTPAMLGSAVFTGALPLDAALAARDADGIALAEALEACGYRDALRSAWMRGAHGARGLEPALAPLHERVDAYFEAHIEQGPVLERHGATIGVVTGGQAIRWLDATVTGAAAHAGTTPMPYRKDALFASAELALAIEALVARHAPDALATIGQSAIDNASRNTIAERVTFSIDLRHPDDARLDAIERELRRVCAQIVGRRGVAVDISRHWSSPATPFDPACIALVEAAARGGGYAHERIVSGAGHDAVHLARCVPSAMVFIPCVGGLSHNAAERALPEHVEAGANVLLGAVLARAGVRERAARSARSPRPAPAMQAAHSGTDAGTFAQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LG8</accession>
    <name>Q63LG8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009897097.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111053.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1047"/>
    <dbReference type="EnsemblBacteria" id="CAH38508">
        <property type="protein sequence ID" value="CAH38508"/>
        <property type="gene ID" value="BPSS1047"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1047"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4239"/>
    <dbReference type="eggNOG" id="ENOG50337CE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEHLRIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021096">
        <property type="entry name" value="Vibrio_phage_VSK_Orf152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12472">
        <property type="entry name" value="DUF3693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="112" mass="12255" checksum="EEBF55367FA62446" modified="2004-10-25" version="1">MKTTVDWLDAVKARLDLPSDYAAAKVLGVTRGAVSKYRNQQSVFDEKTAIRVAEILGVDPFEVIATAHAESSRDDRTKAIWVHALEVFSKGLQGFRWLALPANACGALVLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LK3</accession>
    <name>Q63LK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative voltage-gated clc-type chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551646.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111018.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1012"/>
    <dbReference type="EnsemblBacteria" id="CAH38473">
        <property type="protein sequence ID" value="CAH38473"/>
        <property type="gene ID" value="BPSS1012"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1012"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4191"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFEWKPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="549"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="634" mass="66585" checksum="2A05323AC8413D1B" modified="2004-10-25" version="1">MSIAAPHKRDFASNARLPRIALLALAIGVLGTFAAFALLSLIHLFTNLFFFQRFSFAEHSPALNTLGPWAAAVPVAGGIVVGLIARFGSEKIRGHGIPEAIEAILFGKSRMSPKVAVLKPLASGIVIGSGGPFGAEGPIIMTGGAIGSLIAQFVKVTAAERKTLLVAGATAGMTAVFGTPVAAVLLAVELLLFEWRPRSFLPVALACAVAGFARAAFFGVGPLFPVETAAPTAAALGSCALAGLLSGALACGLSVSLYKIEDRFGKLPVHWMWWPAIGGLAVGIGGLIEPRALGVGYDVIGDLLHGHIALQIALAILVVKAVIWVIALGSGTSGGVLAPLLMLGAGLGTLLGPVLPGGEPALWPLVCMAATLGATLGAPLTAIVFAFGLTHDANALLPLLTATLVAHGFATVAMKRSIMTEKIARRGYHIYREYGVDPLERHYVDEVMTRSAVTIDADLSVEVVRARYFGATQAHRAYPVVRDGVLIGMLDRATLDGSPAAHDGDGQADDARAAKDGQADDARAAKMRAADVQMTDMRVADVRVADVLPRRAPLFSLADETCRLVATRLAVHQLERLPVVADPDTMRVVGIVSRSDLVKPALRHFDDEHKRERFRRAHPAAFVKRRFAPARKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LL5</accession>
    <name>Q63LL5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111006.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1000"/>
    <dbReference type="EnsemblBacteria" id="CAH38461">
        <property type="protein sequence ID" value="CAH38461"/>
        <property type="gene ID" value="BPSS1000"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1000"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5126"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MHEKTFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="26795" checksum="4F4C48C204C372D1" modified="2004-10-25" version="1">MADCVVQVVMQDRENKNTFSDALIRGLGEAFDAIRQNGRCKAAILTGYGNYFASGGTQESLMYLSEGKGTFAEIAASASRNGANLYSLALNCPVPVIAAMQGHGIGGGFVMGLFADFVVLGKECLYTTNFMKYGFTPGMGATLVLPHKLGLPLAQNMLMTARSFYGDELQKLGVPFPVVPRAEVAACALEIAKNLAEKPRLSLVTLKDHLVAELRSRLPAVIEQELAMHEKTFGQPEVKERIRSLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LW8</accession>
    <name>Q63LW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske [2Fe-2S] domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184916.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110903.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0894"/>
    <dbReference type="EnsemblBacteria" id="CAH38356">
        <property type="protein sequence ID" value="CAH38356"/>
        <property type="gene ID" value="BPSS0894"/>
    </dbReference>
    <dbReference type="GeneID" id="56597254"/>
    <dbReference type="KEGG" id="bps:BPSS0894"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7187"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEAVFHI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="11383" checksum="5CEF6CC3D63BAC38" modified="2004-10-25" version="1">MSEQWVCAGHAGALSEDSPIEFKRTDGVEIGIYRVGDDVYALENVCPHAYALLTQGFVDEGTVECPLHEAVFDIKTGQCLKGPGGRALKTYAVRLAGEEIQIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M12</accession>
    <name>Q63M12_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009933604.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110859.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0847"/>
    <dbReference type="EnsemblBacteria" id="CAH38310">
        <property type="protein sequence ID" value="CAH38310"/>
        <property type="gene ID" value="BPSS0847"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0847"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7132"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AHIFRTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="275"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="47510" checksum="FF50056B2B32B184" modified="2004-10-25" version="1">MAISSPDSTLRRATAPAAPPQADADASTHAHDGKIADAALLFDDDPLIRRFAPLFERIAHGAAARDRDRALPYEPVEWLRAAGFTKLRVPRAAGGAGIGLAPFFALIARLGEADPNLPQILRVHGGFIEMLHESADDALRSRWFARVAQGTIVGGATAERSAVTSNTVRLSRENGKLYLDGEKYYTTGTLYADWIDVSANDGDTDLRVLVPAATPGVERLDDWDGFGQRLTGSGTTRFTRVEVEPGDIYRRFDASRPRGNSLLTAYFQTLHLANLAGIARAVLRDAVAFTRDRTRTFGVPGASSPRHDPLVQRVIGRLASLAYSTQSLVATIARTLDDVCAARAAGRATEDAYVRVDIQAFQAQQIVLAQTLEAATLLFEVGGASATSETRRFDRHWRNARVLASHNPAIVREAVIGNYYLNGVGHNERFGIARTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M19</accession>
    <name>Q63M19_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110852.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0841"/>
    <dbReference type="EnsemblBacteria" id="CAH38303">
        <property type="protein sequence ID" value="CAH38303"/>
        <property type="gene ID" value="BPSS0841"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0841"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7119"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHFPVAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="218"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="37991" checksum="C1EFFFC5C109CCC3" modified="2004-10-25" version="1">MWHFPQAVPASLGPWAVFASVLVTQLGMPVPAVPMLIVGGTMAAMGQASYASMLVAAVAATVLADSMWFFAGRARGRRLLNALVRFSLSLDTTLRIARKVLEKHGAPLLVLAKFLPGLGLVSAPLLGTTAVAVWVFLFWDVAGASLWASVWLFGGAALHDEIVRLMQWVSASGGTLFDAFAAIFVTFLLYRWAMRMRFRRWLAKIRISPQQLDAMLKSAAPPIVFDARPRAVREKEAYRIAGAYPLDLDSPDPLHPDLMTRPIVVYCVCPNEATAKRIVSQLQRKRIRHALALKGGLDAWEKHGYPVEPLPADFDAARYAAPPPVERIAPVEPGGRDGGYPMRAGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M35</accession>
    <name>Q63M35_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200921.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110836.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0825"/>
    <dbReference type="EnsemblBacteria" id="CAH38287">
        <property type="protein sequence ID" value="CAH38287"/>
        <property type="gene ID" value="BPSS0825"/>
    </dbReference>
    <dbReference type="GeneID" id="56597148"/>
    <dbReference type="KEGG" id="bps:BPSS0825"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7096"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CCERFED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018024">
        <property type="term" value="F:histone-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="1">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="235" mass="26747" checksum="93B27E2C1962FDF2" modified="2004-10-25" version="1">MLENPVGNLAAEARRLASAWRRGGPGLAARVALDRLCDAALEWRLRIRSGGLVPIESLVAEWHGCHDYYPSSIRAFSRVLRDLHVTPDDVFVDYGSGMGRAIVIAARFPFRALIGVETSDRLHRAAQANVGRALPDADRRRIRLLHCDARRFRLPGSASVLYFYNPFHGDILRAVFADIERSLRQHPRRLRIVFNNPAHFRAIERDYGWLRRSREYAFEYPIAVYETPGCAAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MC9</accession>
    <name>Q63MC9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543612.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110742.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0731"/>
    <dbReference type="EnsemblBacteria" id="CAH38190">
        <property type="protein sequence ID" value="CAH38190"/>
        <property type="gene ID" value="BPSS0731"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0731"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6958"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITHRNIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="453"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="553" mass="59984" checksum="CB743BF4E54038F6" modified="2004-10-25" version="1">MTQKFEEGLGRREANYVPLTPIDFIARAAEVYGERLAVVHGEIRRTWSETYARARRLASALERAGVGRGDTVAALLPNIPAMIEAHFGVPMAGAVLNALNTRLDVASMLFMLRHGEAKVLIVDTEYAEFAHRAALEVPGLAIVSVADAMPADPARFPAALDYEAFLAGGDPAYAWTPPSDEWEAIALNYTSGTTGDPKGVVYHHRGAYLAAISNLLEWDMPKHAVYLWTLPMFHCNGWCFPWAVAARAGVNVCLRKFDAKRVLELIRRERVTHYSGAPIVQSAIANAPAEWRAGIAHEVHAFVAGAAPAPAVIAKMKEIGFDLTHVYGLTEVYGPATVCAKQAHWASLPDDELAQLNARQGVRYHLQAGATVLDPDTMAPVPADGETLGEIMFRGNLCMKGYLKNPHATDEAFAGGWFHTGDLGVLTPDGYIRIKDRRKDIIISGGENISSIEVEDALYRHPAVAVAAVVALPDPKWGEVPCAFVELRDGMSATEEEIIAHCRLLLAAYKIPKTVRFGELPKTSTGKIQKFQLRAQVGSSSAIDLVAAARKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MF0</accession>
    <name>Q63MF0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194630.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110721.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0707"/>
    <dbReference type="EnsemblBacteria" id="CAH38167">
        <property type="protein sequence ID" value="CAH38167"/>
        <property type="gene ID" value="BPSS0707"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0707"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6923"/>
    <dbReference type="eggNOG" id="COG3217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYPFLLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="121"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="289" mass="31086" checksum="D35A8BDBFFC9DEC1" modified="2004-10-25" version="1">MPVISELFVYPIKSCAGIATVRAQLLVTGLEYDRNWMVTDPTGAMLTQRTHPRLALVRTAIGERELVVTAAGMPELRTPLAASALAGAERLAATVWRDTVSALDTGAHAARWFSEFLGAPARLARFAPDARRVVGAKWTGPFTSYAQFADGFPLLVVGQSSLDDLNVRLRRKGASAVPMNRFRPNVVLVGLDAYEEDYVDYLDVQTGGGGVRLSLVKLCTRCPVPTIDQRTGAPDPAWPNEPTDTMSLYRGSKQFGGALTFGKNAIVLNGDGAFLEVGQSVDAEIAFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ML9</accession>
    <name>Q63ML9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535157.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110652.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0631"/>
    <dbReference type="EnsemblBacteria" id="CAH38088">
        <property type="protein sequence ID" value="CAH38088"/>
        <property type="gene ID" value="BPSS0631"/>
    </dbReference>
    <dbReference type="GeneID" id="56597684"/>
    <dbReference type="KEGG" id="bps:BPSS0631"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6818"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SWSRLYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="163"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="41825" checksum="03FDDD82A9997793" modified="2004-10-25" version="1">MNSTQAHRLSPFRYLKWRWLHFRRSWTDTRADRIPSWSRLYLRTYLHLVGLVLVTVGGTIAVLCSALGPRTVWRALDALPGGALPLAAFVLAVPALAGYRWMRPVWSDLVMVRARAIDFTGGRFNTRARESRSVIIGPLARTLNALAMRMERLIATQRDLTNGISHELRTPLARVRFALESLREPGSAAEYQNAIDSIEQDVSELDELIDMSLTYARLEYSSLQSNLEQTALVAWFDKQVADAALLYPSKAIEARVALPAELRVKMDKRLMSYAMRNLLRNASKHARGRISVGLRIRHGNIEIDVEDDGPGVPPDERERIFDAFVRLDRHTAGYGLGLAITRLVLQAHNGRVAVVDPLRLPGARFEMSWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MU9</accession>
    <name>Q63MU9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V4R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186987.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110570.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0549"/>
    <dbReference type="EnsemblBacteria" id="CAH38006">
        <property type="protein sequence ID" value="CAH38006"/>
        <property type="gene ID" value="BPSS0549"/>
    </dbReference>
    <dbReference type="GeneID" id="56531001"/>
    <dbReference type="KEGG" id="bps:BPSS0549"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6717"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KSAYFWC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045987">
        <property type="entry name" value="DUF5943"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19367">
        <property type="entry name" value="DUF5943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="177" mass="19692" checksum="FF221FDDAD889791" modified="2004-10-25" version="1">MQPQLPIDVDPNTGVWTTDALPMLYVPRHFFTNNHTAVEEALGRDAYADILYRAGYKSAYHWCDKEAKQHGIAGMAVFEHYLKRLSQRGWGLFSIVEAEPAAARAKIELRHSSFVLAQPGKEGKLCYMFAGWFAGALDWVNDTTPEGRGAPRARSAEAQCAAEGHDHCVFEVSPIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MV0</accession>
    <name>Q63MV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Family M19 non-peptidase homologue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186989.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110569.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0548"/>
    <dbReference type="MEROPS" id="M19.950"/>
    <dbReference type="EnsemblBacteria" id="CAH38005">
        <property type="protein sequence ID" value="CAH38005"/>
        <property type="gene ID" value="BPSS0548"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0548"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6716"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDHPRNI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="35829" checksum="6CBFA5D0699405E4" modified="2004-10-25" version="1">MSTLHQDSIIIDGLNISKFERSVFEDMQKGGVTAANCTVSVWENFTKTVDNIALMKKQIRENGELLTLVRTTDDILRAKREGRTGVILGFQNAHAFEDNLGYVEAFADMGVRVVQLCYNTQNLVGTGCYERDGGLSDFGREVITEMNRVGIMVDLSHVGGNTSSEAIAFSKKPVCYSHCLPSGLKEHPRNKSDAQLKEIADAGGFVGVTMFAPFLKRGIDATIDDYIEAIGYVVNLIGEDAVGIGTDFTQGYSVDFFDWLTHDKGRYRRLTNFGKVVNPEGIRTIGEFPNLTAAMERAGWKASRIRKIMGENWVRVFKEVWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N29</accession>
    <name>Q63N29_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205416.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110490.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0468"/>
    <dbReference type="EnsemblBacteria" id="CAH37924">
        <property type="protein sequence ID" value="CAH37924"/>
        <property type="gene ID" value="BPSS0468"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0468"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6615"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VCEKYNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="472" mass="52042" checksum="F7E69A3410D5827A" modified="2004-10-25" version="1">MSYRPSNASAWIQPAAPAHRTSAEYRALDAAHHLHPFSDMGSLNRAGSRVIVKAEGVHLWDSDGNRIIDGMAGLWCVNVGYGRDELIEAGSRQLRELPFYNTFFKTTHPPVIELSALLAQIAPPAFNRFFYCNSGSEGNDTVLRIAHQYWRAQNRPQKKFVISRRNGYHGSTIAGATLGGMSYMHEQMPSKVEHIVHIDQPYYFGEAREGQTPEAFGLERARQLEAKILELGAQNVAAFIGEPFQGAGGVIFPPSTYWPEIERICRQYDVLLVADEVIGGFGRTGEWFAHQHFGFAPDLMTLAKGLTSGYVPMGAVALSDRIADALIAHGEFNHGMTYSGHPVAAAVAIANLKVLRDERIVERVKTDTGPYFQQRLRETFANHPIVGDIAGAGLVAGIQLAREPRTRKRFENGGEVGTICRDYCFNGNLIMRATGDRMLLSPPLVISKPQIDEIVEKAKRAIDATAQQLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N63</accession>
    <name>Q63N63_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553190.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110456.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0433"/>
    <dbReference type="EnsemblBacteria" id="CAH37889">
        <property type="protein sequence ID" value="CAH37889"/>
        <property type="gene ID" value="BPSS0433"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0433"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6572"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FTNHVTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="226" mass="23319" checksum="9C77E170E0394BF3" modified="2004-10-25" version="1">MKPNLPSLLTFNGGYVDTAGFLALQGLFTAHVTGNFVTLGATLVAGSTGAIAKLLALPVFCGVVLAAGVARRLMLRAHAPALKILLGVQWLLLVAGAALAIRLGPFANGDAWPAIATGMALVMAMAIQNAVHRLHLPDALPTTLMTGTVTQLMLHLSERIAGDAAPVRGSPARLANMAWTVVTFALGCAAAALAYLLGGAWAFALPPVLIAFALFLGDERKLEHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N74</accession>
    <name>Q63N74_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide biosynthesis protein (O-antigen-related)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbH</name>
        <name evidence="2" type="ordered locus">BPSS0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939427.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110445.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0421"/>
    <dbReference type="EnsemblBacteria" id="CAH37877">
        <property type="protein sequence ID" value="CAH37877"/>
        <property type="gene ID" value="BPSS0421"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0421"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6557"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRDCWCP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="450" mass="49549" checksum="A6E8EF3FAC452EBD" modified="2004-10-25" version="1">MDIIRPTFAPDAARSPDAIRAEIAALVREYANATQARAPFVPGRTPVPVSGKVIGAPELQHMVDASLDGWLTTGRFNTAFENRLARYLGVTHVITVNSGSSANLVAFSTLTSDRLGERAIRPGDEVIGVAAGFPTTVNPILQFGAVPVFVDIELGTYNVDATKLEAALSPRTRAIMLAHCLGNPFNVEAVTSLCRKYGLWLIEDCCDALGARYDGRLVGTFGDIATLSFYPAHHITMGEGGAVFTNNDELARIAESFRDWGRDCYCAPGADNTCGKRFCWQLGELPRGYDHKYTYSHCGYNLKITDMQAACALAQMDRVDGFIERRRGNFAYLKERLSSCDAFLHLPQATFNSNPSWFGFPLTLREDTGVARVDLLDYLSQGGVGTRLLFAGNLTRQPYMRHRRYRVSGELAVTDAVMERTFWIGVFPGLDEAMLDYACTKIETFLGINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NK3</accession>
    <name>Q63NK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529841.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110316.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0296"/>
    <dbReference type="EnsemblBacteria" id="CAH37744">
        <property type="protein sequence ID" value="CAH37744"/>
        <property type="gene ID" value="BPSS0296"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0296"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6401"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDEHYEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="219" mass="24776" checksum="DA1FDF79857D034E" modified="2004-10-25" version="1">MEKISSDTGSAYDEIRSRIFDGRLSPGQKISHRGLAHELGVGQMPVRSALQLLASEGLVNIVDKSGTFVNEPTRDDLREIYELRLALESTAAYLAARGGVTDGLSRSHAQMRRLVDENIADIMTEQKIGWVFHDEIFKAARNDRLFTTYKLLRAQTHALNELPRSDFATVRRGTLEHLEIYAAIDARDAETARRRMWNHVIDGTPDRIRLIRAQYDTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P50</accession>
    <name>Q63P50_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205338.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110119.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0096"/>
    <dbReference type="EnsemblBacteria" id="CAH37542">
        <property type="protein sequence ID" value="CAH37542"/>
        <property type="gene ID" value="BPSS0096"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0096"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6124"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GADEWIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="429"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="558" mass="60968" checksum="89F574078AD51BD5" modified="2004-10-25" version="1">MSRQIRFWLVWGAIPFVVLASLCLPLRMQPDWSHVLTIVLIIAAIVLAIEIFEHSRETAQDRAAEAEIDDHELAVIIVAGPHASSLFNSSGDDTAFRREAGALWLRADSVEQLRDTMMRVKASRGRFPDAAVVPLVSESDDESDMRQAFAKWRTELREALCYPDAAYVLPCYLAVYTCLGFKGADGARPKWTGDAIEIGTRQMNAASKVGELLASIRQQLLRPSPTGSSAQCALGLGVFDWLDATALLSSMTMLANTPPFMLKGLTLANVGRRPIRPGAWTRWLTVRTGLHIRQTKSSMAPLPVPRVAKHAESGIREGWSSARHLVSTRASFVPALVFSTVSTLGIAVAVSGWMNSRMIQRVSNDIADYRSGADEWIGRKRFAQARLEHDRTAIVQTLLDGVPTGFGWGLYRGQELLVKLDTVLDSPRTASIAMQLDTVSLFAAGKATFSPGAAQRELQHALRMILANPEQRVLIVGHADSSGSDAANFQLSEARARAIRDWFVDQGVLKTRFIVQGAGDTHPIADNDSPSGRAQNRRVEVLLIPDVASDRKASGTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P55</accession>
    <name>Q63P55_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205334.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110114.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0091"/>
    <dbReference type="EnsemblBacteria" id="CAH37537">
        <property type="protein sequence ID" value="CAH37537"/>
        <property type="gene ID" value="BPSS0091"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0091"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6119"/>
    <dbReference type="eggNOG" id="COG3539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGQYYAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266500" evidence="1">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="181" mass="18905" checksum="4DC99CDEF9037408" modified="2004-10-25" version="1">MKKKVVSFAVATLFGLVAAQSVYAQSIDQGQVKFTGELTANTCTIDAGSKDQIVPLPKVSTSALAAPGDVAGSTAFEIKVSKCAADVKKVAAHFEMENMDPNTRTLKNEATGTDAATNVTIQLVNSDGTELPVGSTGSYFDVTGTDDARGATMIYGGQYYALDTTTAGKVESHTLFTLAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PB1</accession>
    <name>Q63PB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fatty aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539579.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110058.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0034"/>
    <dbReference type="EnsemblBacteria" id="CAH37477">
        <property type="protein sequence ID" value="CAH37477"/>
        <property type="gene ID" value="BPSS0034"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0034"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6035"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDLCAQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="526" mass="54764" checksum="CE5F2A60AF4C08FC" modified="2004-10-25" version="1">MQITGEMLIGAAAVRGSEGTMRAYAPAQGVELEPTFGAGGAADVDRACRLANAAFDPFRQAPLETRARFLEAIAERIVGLGDPLIERAHAESALPVARLEGERARTVGQLRLFAAIVRDGRWLSATLDSAQPERKPLPRADLRLQKIPVGPVAVFGASNFPLAFSVAGGDTASAFAAGCPVVAKAHPAHLGTSELVGRAIRQAVADCGLHEGVFSLVVGAGNAIGEALVAHPAIRAVGFTGSRAGGLALMGVAARRREPIPVFAEMSSINPFFVLPGALRARGAQIAQGFVESLTLGVGQFCTNPGLVVALEGPDLKAFVDAAAQALSQKGAQTMLTSGIASSYESAVAARRAAAGVSEVARGARSDARNAALPALFTTTHTQFVQNPQLEAEIFGPTSLVVACRDIDEMIALAEHVEGQLSATLHLEDDDVDLARKLLPTLERRAGRIVANGYPTGVEVAYAMVHGGPFPATSDPRSTSVGALAIERFLRPVCYQDLPAALLPEALADANPLGLWRLRDGQLGKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PF1</accession>
    <name>PHS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="1">PHS</shortName>
            <ecNumber evidence="1">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="1">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL3425</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110018.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PF1"/>
    <dbReference type="SMR" id="Q63PF1"/>
    <dbReference type="STRING" id="272560.BPSL3425"/>
    <dbReference type="EnsemblBacteria" id="CAH37437">
        <property type="protein sequence ID" value="CAH37437"/>
        <property type="gene ID" value="BPSL3425"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3425"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1760"/>
    <dbReference type="eggNOG" id="COG2154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAEKWNH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231444" description="Putative pterin-4-alpha-carbinolamine dehydratase">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <sequence length="101" mass="11681" checksum="7B7B98F607C62FDC" modified="2004-10-25" version="1">MIHKLTSEERKTQLESLHHWTAVPGRDAIQRSLRFADFNEAFGFMTRVAIKAQEMNHHPEWFNVYNRVDVTLSTHDANGLTERDIKLAHFIDEVGKHAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PF7</accession>
    <name>Q63PF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205317.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110012.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3419"/>
    <dbReference type="EnsemblBacteria" id="CAH37431">
        <property type="protein sequence ID" value="CAH37431"/>
        <property type="gene ID" value="BPSL3419"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3419"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1766"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NEGVGYF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="6">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="561" mass="60780" checksum="E5FE7848F626E047" modified="2004-10-25" version="1">MTTERTLEGEFDYVIVGAGTAGCVLANRLTEDPEVTVLLLEAGGRDDYHWIHIPVGYLYCIGNPRTDWLYKTEPEAGLNGRALSYPRGRVLGGSSSINGMIYMRGQRGDYDDWARATGDAGWSWDSVLPVFRRSEDHHAGATDMHGAGGMWRVEKQRLRWEILEAFSQAAQQTGIPATDDFNRGDNTGVGYFEVNQKCGIRWNASKAFLRPALARPNLTVITGAQAERLVFDGKRCAGVEYRGGGAPFVARARVEVLVASGAVNSPQLLELSGIGDGSRLQALGIGVIADLRGVGENLQDHLQLRMAFRVRGVRTLNTLSAHWWGKLWIGAQYALMQRGPMSMAPSQLGAFAKSDPNDPALARPDLEYHVQPLSLERFGEPLHRFNAFTASVCHLRPTSRGSVHAASPDPARAPSIAPNYLSTDYDRHVAANALRLTRRIASAPALARYAPEEILPGARYVSEAELIAAAGAVGTTIFHPVGTCRMGRADDPDAVVDSRLRVRGVTGLRVVDASVMPTITSGNTNSPTLMIAERASDMIRADRRGASERGASARAEAVLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PK7</accession>
    <name>Q63PK7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530447.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109962.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3367"/>
    <dbReference type="EnsemblBacteria" id="CAH37380">
        <property type="protein sequence ID" value="CAH37380"/>
        <property type="gene ID" value="BPSL3367"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3367"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1832"/>
    <dbReference type="eggNOG" id="ENOG5033T7H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VLFCPTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="38355" checksum="A5CA947D1120E105" modified="2004-10-25" version="1">MTPTLDETALPPADALAYPGTLLSPDGRLVAPYDLERPGADARGHVGAAARAGLLHAASGPFTLDYATLSTVHVINGMGVALGDSVVGLTALAAIKARHPHVHFVLYRPAHAPAYVDALYRLAADAIAPIRALPWPAAELPARDTRIDLGNHLYWPAFAARPMIDFFLASLGVPPESISADAKCNRWLARLTLPPLPPEWRDRPYALFCPQASTPLRSIPAAQRAALVERLARTYRLPVLGFGPIDHPDYVDVSGHSADTAQFVSWVGRARVALCSDTSAVHIAAGFDVPTLACFSSIAPELRVRDYPLCTAIELDMPEMLRNRHKSDAANDIAQVDAAYRRIDWDAIAWPPARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PZ7</accession>
    <name>Q63PZ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ordered locus">BPSL3227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551020.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109821.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3227"/>
    <dbReference type="EnsemblBacteria" id="CAH37238">
        <property type="protein sequence ID" value="CAH37238"/>
        <property type="gene ID" value="BPSL3227"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3227"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2011"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLWLTDK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01650">
        <property type="entry name" value="SECETRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="126" mass="13656" checksum="516169CE5335AAA4" modified="2004-10-25" version="1">MANPSVETVNTSGDKLMLALGVLLVLAGFAGFFLLGGKEWYVRGAALVVGVIAGVGVALMSLPGKSFIAFAKDSYREVRKVVWPTRKEATQTTLVVFGFVLVMALFLWISDKSIEWAIFSVILGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q51</accession>
    <name>Q63Q51_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
            <ecNumber evidence="6">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">mrcA</name>
        <name evidence="25" type="ordered locus">BPSL3174</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EC" id="3.4.16.4" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109767.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3174"/>
    <dbReference type="EnsemblBacteria" id="CAH37184">
        <property type="protein sequence ID" value="CAH37184"/>
        <property type="gene ID" value="BPSL3174"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3174"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3626"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LAQMAMI"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031376">
        <property type="entry name" value="PCB_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17092">
        <property type="entry name" value="PCB_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="20" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11 25" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="25" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Transgly" evidence="23">
        <location>
            <begin position="54"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PCB_OB" evidence="24">
        <location>
            <begin position="313"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="22">
        <location>
            <begin position="422"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAH37184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="773" mass="84466" checksum="54EF948CC334373E" modified="2004-10-25" version="1">MLGVAGVCVALAVSIGLVLGYALVVASPNMPSLDALTDYRPKVPLRIYTADHVLIGEFGEERRDIVRLQDVPDSLKKAVLAIEDARFYEHGGVDLTGIIRAGIVALTNGHATQGASTITMQVARNFFLSSEKTYTRKIYEMLLAYRIERALTKDQILEVYMNQIYLGQRAYGFAAAAHAYFNKDLKDITLAEAAMLAGLPKAPSAYNPVANPKRAKVRQQYILQRMLELNFITREQYDEALAEPLVVKSPSREYSVHAEYVAEMVRQMMYAQYKDEAYTRGLNVVTTIDSADQTLAYRALRKGLMTYDRRHGYRGPEGFIELPANADDREQAIDDALVDHPDNGELIAAVVTEASARQIRVVFPNGSDATVSGDDLRFAASSLSSNAQPNKRIRPGAIVRVFKNDDGSWAIGQLPQIEGAFISIVPQDGAIRSLIGGFDFNKNKFNHVTQAWRQPGSSFKPFIYSASLDKGLGPATIINDGPLYFSAAETGGQPWEPKNYGGGFEGPMSMRVALQRSRNLVSIRILNHIGPKYAQQYITRFGFDADRHPAYLPMALGAGLVTPLQMAGAFSVFANGGYRINPYLIAEVTDPSGNVVARAQPLVAEQNAPRAIDPRNAYVMNSLLQSVAQRGTGARSNVLKRTDLAGKTGTTNDSRDAWFGGYQHTLAAIAWIGYDSPRSLGDRETGGGLALPVWIDYMGPALKNVPEYKMPMPDGVTTLGGELYFDQFMPGRGFVATVGVNLAAAPPNSASDVPGHVDEQEKQDIMNLFRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q63</accession>
    <name>Q63Q63_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ugpQ</name>
        <name evidence="2" type="ordered locus">BPSL3162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196745.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109755.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3162"/>
    <dbReference type="EnsemblBacteria" id="CAH37172">
        <property type="protein sequence ID" value="CAH37172"/>
        <property type="gene ID" value="BPSL3162"/>
    </dbReference>
    <dbReference type="GeneID" id="56594066"/>
    <dbReference type="KEGG" id="bps:BPSL3162"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2077"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="10"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="253" mass="26970" checksum="87F083F34751DDBA" modified="2004-10-25" version="1">MTNLQTWPYPRVVAHRGGGALAPENTLAALDAGAHYGHKMVEFDAKLSADGVAFLLHDDTVERTSNGAGAARDMRYAALEALDAGAWYDARFSGERMPTLAQAAARCLALGLAANVEIKPCPERDAETGSVVAALAAELWRDAAVPPLLSSFSAAALDAAREAAPALPRGMLYEEIPAGWLEQTQRLGCVSLHAHHAQFNAALVRDLKASGLRLLAYTVNDPVRARELADWGVDLICTDRIDLIGADFADREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q66</accession>
    <name>Q63Q66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase large subunit</fullName>
            <ecNumber evidence="16">1.4.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">glt1</name>
        <name evidence="16" type="ordered locus">BPSL3159</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="16"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196742.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109752.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3159"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="EnsemblBacteria" id="CAH37169">
        <property type="protein sequence ID" value="CAH37169"/>
        <property type="gene ID" value="BPSL3159"/>
    </dbReference>
    <dbReference type="GeneID" id="56594069"/>
    <dbReference type="KEGG" id="bps:BPSL3159"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2081"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="27"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH37169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1567" mass="170743" checksum="8805907D7A486DF0" modified="2004-10-25" version="1">MIDHQQPKSALPAAQGLYDPQNEHDACGVGFVAHIKGKKSHEIIEQGLKILENLDHRGAVGADPLMGDGAGILIQIPDAFYREEMARQDVTLPPAGEYGVGMIFLPKESASRIACEQELERTVKAEGQVVLGWRDVPVDHAMPISPAVKASEPVIRQIFIGRGKDVMVTDALERKLYVIRKTASHRIQALKLKHGKEYFVPSMSARTVVYKGLLLAGQVGVYYRDLQDARTVSALALVHQRFSTNTFPAWELAHPYRMIAHNGEINTVKGNVNWLNARTGAIASHVLGDDLPKLWPLIYPGQSDTASFDNCLELLVMAGYPLVHAVMMMIPEAWEQHTLMDDNRRAFYEYHAAMMEPWDGPAAIAFTDGRQIGATLDRNGLRPARYVITDDDLVIMASEAGVLPIPESKIVKKWRLQPGKMFLIDMEHGRIIDDKELKDNLANAKPYKSWIDAVRIKLDEIEPEGEDVAAERRSAAALLDRQQAFGYTQEDVKFLMAPMAQQGEEAVGSMGNDSPLAVMSNKNKTLYHYFKQLFAQVTNPPIDPIRENMVMSLVSFIGPKPNLLDTNNINPPMRLEVSQPVLDFKDIAKIRSIDRYTGGKFSAYELNICYPVAWGKEGIEARLASLCAEAVDAVKSGYNILIVSDRKTDAENVAIPALLATSAIHTHLVQQGLRTSTGLVVETGSARETHHFALLAGYGAEAVHPYLAMETLAKMAHGLPGDLSPEKAIYNFTKAVGKGLQKVMSKMGISTYMSYTGAQIFEALGLATDLVEKYFKGTASKVGGIGLFEVAEEAIRLHRDAFGENPVLADMLDAGGEYAFRVRGEDHMWTPDSIAKLQHATRGNSYQTYKEYAHLINDQTKRHMTLRGLFEFRVDPAKAIPIDEVEPAKEIVKRFATGAMSLGSISTEAHTTLAIAMNRIGGKSNTGEGGEDENRYRNELRGIPIKVGDTLKSVIGDEIVRDIPLKEGDSLRSKIKQVASGRFGVTAEYLASADQIQIKMAQGAKPGEGGQLPGHKVSEYIGKLRYSVPGVGLISPPPHHDIYSIEDLAQLIHDLKNVNPVASISVKLVSEVGVGTVAAGVAKAKADHVVIAGHDGGTGASPLSSVKHAGTPWELGLAETQQTLVLNRLRGRIRVQADGQMKTGRDIVIGALLGADEFGFATAPLVVEGCIMMRKCHLNTCPVGVATQDPVLRAKFSGQPEHVVNYFFFVAEEAREIMAQLGIAKFDDLVGRADLLDMRRGVEHWKAKGLDFSRVFYQPEGCEGIARRHVESQDHGLERALDHTLIEKAKAAIENGEHVSFIQPVRNVNRTVGAMLSGAIAKKHGHDGLADDAVHIQLKGTAGQSFGAFLAKGVTLDLVGDGNDYVGKGLSGGRIIIRPTNDFRGKSEENIICGNTVMYGALEGEAFFRGVAGERFCVRNSGATAVVEGTGDHGCEYMTGGTVVVLGETGRNFAAGMSGGIAYVYDADGTFAAKCNKSMVALDPVLQQAEQERTVDPALWHAGTTDEALLKGLVERHFQFTGSPRAKSLLENWDAARRQFVKVFPHEYKRALGEIGAKKKAGEVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QE2</accession>
    <name>Q63QE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109676.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3081"/>
    <dbReference type="EnsemblBacteria" id="CAH37092">
        <property type="protein sequence ID" value="CAH37092"/>
        <property type="gene ID" value="BPSL3081"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3081"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3528"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPWRFLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="205" mass="22384" checksum="4DE801DF689F9ED2" modified="2004-10-25" version="1">MRKRMSVKPAPTSVSIHELIAGRWSPRAYSSEPVSAEHLHAVLEAARWAPSAYNAQPWRFIVFDRSKDEVAFKRAFSTLVPFNQGWNAPAPVLIAVTAHTLTSKGEPSPTALYDAGAAAMSLVLQAHALGLAAHQMSGFDVKAFRAAFAIPADVEPLAIISIGHYGDADKLDPVLRERERAVRTRHPIGEVVYAHAWQKPFPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QL7</accession>
    <name>Q63QL7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl-diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispB</name>
        <name evidence="3" type="ordered locus">BPSL3006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109601.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3006"/>
    <dbReference type="EnsemblBacteria" id="CAH37017">
        <property type="protein sequence ID" value="CAH37017"/>
        <property type="gene ID" value="BPSL3006"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3006"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3435"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35826" checksum="0CA97F7BB4DDA690" modified="2004-10-25" version="1">MIMSSTATPSLSAAHLLAPIASDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPALLLLVAGALGENTNQKHVLAAVVEFIHTATLLHDDVVDESELRRGRKTANALFGNAASVLVGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLLNMHDADVDEARYMQVIRYKTAKLFEAAARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAESMGKNAGDDLREGKPTLPLIYLIERGTPEQSTLAREAIEHGGTDRFDTIFDAITRSGALDHTLECARQEAQAAAAAISSFPSSNFKESLLELCSYSTSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QP7</accession>
    <name>Q63QP7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exoribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527764.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109571.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2977"/>
    <dbReference type="EnsemblBacteria" id="CAH36987">
        <property type="protein sequence ID" value="CAH36987"/>
        <property type="gene ID" value="BPSL2977"/>
    </dbReference>
    <dbReference type="GeneID" id="56528219"/>
    <dbReference type="KEGG" id="bps:BPSL2977"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2297"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWCLRWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="235"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="692" mass="75695" checksum="6262AFF83CDF6A55" modified="2004-10-25" version="1">MNVFFEESGSFKAGSVLSRQGDAFQVELPGGRRAKVRAKDVLIEFEKPAAGELMQQADEAAQQIDLDFLWECAPAEEFAYAALADEYFGASYGPVERAALVLRLHGAPVYFRRKGRGQYQRAPEEQLKMALAGLERKRQQALVQAGYEEELKAGRLPDAFAGKALGLLTKPDKNSIEYKALDAAALARGVSPARLMLDCGGIPSARALHEARFLAEYFPHGTGFPAVAVGKLPEDLPRADVNAFSIDDITTTEIDDAFSVEHLSDGRVRIGVHIAAPALGIVRGDAVDAIARARLSTVYMPGDKITMLPDDVVDVFTLKEGDYRPALSLYIIVKRDTQEIVANETRAEYVYVKSNLRHNTLDELVTEDALAAGTGDYPHKDDIAALWPLAQALFERRQVARAGYGLKREVQRNTDYNFYVEGEHVSITPRRRGSPLDLIVSELAILANSTWGAFLHDHSVPGIYRTQRAFGMPSGPKRTRMQTSAAPHEGLGVPQYAWSTSPLRRYVDLVNQWQLLACVQHGVTAKLAAPFKQKDADLYAVVQGFDDTYAAYADHQRRMEYFWCLRWIKQEGRKQVSATVVKGELVRLDEVPLLLHVPALGVHARGTRVLLDVMSVDELTIEASVRLVSVLDAPMVSSGEPADEDEDADAADETLLDAADESAQGEAEALAEAGGAASGNGESSANGEEQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU4</accession>
    <name>Q63QU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gluconate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195053.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109524.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2930"/>
    <dbReference type="EnsemblBacteria" id="CAH36940">
        <property type="protein sequence ID" value="CAH36940"/>
        <property type="gene ID" value="BPSL2930"/>
    </dbReference>
    <dbReference type="GeneID" id="56593767"/>
    <dbReference type="KEGG" id="bps:BPSL2930"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2351"/>
    <dbReference type="eggNOG" id="COG2610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMRIGIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="453" mass="47326" checksum="31C805C79412F418" modified="2004-10-25" version="1">MGAVQGSMLLIYTVIAIAVLILMIARYKVYPFLVLIIVSLGLGLAVGMPMDKIVKSFEGGTGGTLGHIAIVVGLGTMLGKMMAESGGAERIATTLIDWFGEKNIHWAMMFVAIIVGLPVFFEVGFVLLIPIAFNVAKRTGKSLLVVGLPMVAGLSVVHGLIPPHPAALLAVQQYGADIGKTIAYGLIVGVPTAIVAGPLFALTISKFVKLPEHNPLASQFVETRAAGETRALPSFGITLFTILLPVVLMLVGSWADLVFAPKSLPNSLLRFAGNSDVALLIAVLVSFFTFGKLQGFNREQIQKFCGDCLAPIAGITLIVGAGGGFGGILRDSGISQQIVATATHAHLSPLLLGWFVAALIRLATGSATVAMTTACGIVAPIAAASGVTVRPELLVLATGSGSLIFSHVNDGGFWLIKEYFGMTVGQTFKTWTLLETIISVLGLTFTLALSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R85</accession>
    <name>Q63R85_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="12">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="4 12">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">wcbS</name>
        <name evidence="12" type="synonym">lpxC</name>
        <name evidence="13" type="ordered locus">BPSL2788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4 12"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527661.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109383.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2788"/>
    <dbReference type="EnsemblBacteria" id="CAH36797">
        <property type="protein sequence ID" value="CAH36797"/>
        <property type="gene ID" value="BPSL2788"/>
    </dbReference>
    <dbReference type="GeneID" id="56528409"/>
    <dbReference type="KEGG" id="bps:BPSL2788"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2521"/>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PSHEMNY"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:5346"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH36797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="305" mass="33141" checksum="F5CDAEC457367B70" modified="2004-10-25" version="1">MSVPTGWATSQGTLARALTIDGHGLHTGRRVGVRILPARPEDGVTGIAFRRVEQGRTLATLPVDPALRRAQPLCTMLRNADGVGVRTVEHLLASLLACEIDHAIVELDAEEVPILDGSATPWVDAIRTCGRVALDAPKRFIRVLRTVVVTEGEGEQRREMRIEPAPRYELSVRNDLRGFGEMHWDGALTPAAFATEIAPSRSYGRVKWAVPAILAGYLRGVPILRGARPSCTASIVGKRVLGGMRLPDEFVRHRVLDLVGDLALAGAPLLARVSAVRPSHEMNFRLVDALLAEPGAWQWADFSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R96</accession>
    <name>Q63R96_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative O-antigen translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938547.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109372.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2777"/>
    <dbReference type="EnsemblBacteria" id="CAH36786">
        <property type="protein sequence ID" value="CAH36786"/>
        <property type="gene ID" value="BPSL2777"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2777"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3171"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWFDAQS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="424" mass="44717" checksum="23FB4138D5BE24FB" modified="2004-10-25" version="1">MRAREREDATMIRVRDSLISLCGVVAGQAALFGCISLIGRFQGPEALGHFNYLLALATFAGTLLACRYELACVSDNPADSFNAFVNVMVLAGAAVSIGCVAIAVAGRTDLYIVAAYGFAAFAQLAAGGYLNSLRRYGWIAASRIAVNGSFLVGVLAATFAPTFRARSGSIDAFRAYAAITAAVALLMLIAVALHGRRRGYSFAVTRAFFVEHSRFAKYILPSTLCGSVLTYALAIVIPHWFDAQSAGYFAAAYRLGFFPVSLIAQSLGGVFRRDAMAAMAGDDAHVLVPKVFGAYARALALLAAGYALGGALLFGPLVELFFGARWNGAIAFFLCMIPLFAFQMIYVPLSQIFLAARAQRIDFLFQLGCGAVLAGALVTAKLAGLPVLASVRLFSFSGAVLMIAGIALTFSVMSGSVSRRRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RE0</accession>
    <name>Q63RE0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186349.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109328.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2732"/>
    <dbReference type="EnsemblBacteria" id="CAH36740">
        <property type="protein sequence ID" value="CAH36740"/>
        <property type="gene ID" value="BPSL2732"/>
    </dbReference>
    <dbReference type="GeneID" id="56528465"/>
    <dbReference type="KEGG" id="bps:BPSL2732"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2592"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KNWLPIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="48"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="404" mass="43094" checksum="7DA3585816E326B6" modified="2004-10-25" version="1">MSTTDHSPIPCPVVVPLDAILPEEPLLMMGAGPVPIPAAVAKANTIVINHLGATMAKIIEQVKEMARYVFQTRTKWVLGVAGPGSAAMEMAVSNLAWAGTKVLSIKNGFFSARMAEMAMRVGADVATIDVPDRSVASLDEIADAIARERPEIVTIVHGETSNTVWNRHLKEIAAIAKAAGALVVVDAVCTLSTMPLDMDAWGIDAVITGGQKGLSSIPGVSLIAFSDQAWERMKSRPEPNTHWCLDMALAENFWHNAGYHYTAPVSGVLALHEALRLVCAETLENRYARHLRCSLALQAGITGMGLELYAPEACRLNSVVGIAAPRGLTPGLICGHISKQYQVEISGSFGLPIVRIGQMGEQCREHNLFRTLHAFGRTMVDLKVAVDLPAGVAALEQALSGRAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RL3</accession>
    <name>URE1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease subunit alpha</fullName>
            <ecNumber evidence="1">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureC</name>
        <name type="ordered locus">BPSL2659</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="1">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205201.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109255.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RL3"/>
    <dbReference type="SMR" id="Q63RL3"/>
    <dbReference type="STRING" id="272560.BPSL2659"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="CAH36667">
        <property type="protein sequence ID" value="CAH36667"/>
        <property type="gene ID" value="BPSL2659"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2659"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2685"/>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFDSHIH"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000234148" description="Urease subunit alpha">
        <location>
            <begin position="1"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Urease" evidence="1">
        <location>
            <begin position="130"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <sequence length="568" mass="60736" checksum="351B1622B0E806DE" modified="2004-10-25" version="1">MTLRLSRRAYAEMYGPTTGDRIRLADTELLIEVERDHTLYGEEVKFGGGKVIRDGMGQSQLPAADVADTVITNAVILDHWGIVKADIAIKHGRIAAIGKAGNPDIQPGVTIAIGAATEIIAGEGLIVTAGGIDTHIHFISPQQIDEALASGVTTMIGGGTGPATGTNATTCTPGPWHMERMLQAADGWPINLGFLGKGNASRPQPLVEQIEAGAIGLKLHEDWGTTPAAIDNCLTVADDTDTQVAIHTDTLNEAGFVEATVAAFKGRTIHTYHTEGAGGGHAPDILKVCGEANVLPSSTNPTRPYTINTLDEHLDMLMVCHHLDPSIAEDLAFAESRIRRETIAAEDILHDLGALSMLSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALTGDGARNDNFRAKRYVAKYTINPALTHGIAHEVGSIEPGKWADLVLWEPAFFGVKPAMIIKGGMIAVAQMGDPNASIPTPQPVHYREMFATRGGALARTSLTFVSQLALDAGISARYGLAKRLVPVRGCRTVTKRDMIHNAWQPAIRVDPETYDVVADGALLTCEPAAVLPMAQRYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU5</accession>
    <name>Q63RU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547729.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109172.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2575"/>
    <dbReference type="EnsemblBacteria" id="CAH36583">
        <property type="protein sequence ID" value="CAH36583"/>
        <property type="gene ID" value="BPSL2575"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2575"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2788"/>
    <dbReference type="OMA" id="FRGPNEP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="26216" checksum="E1B11C4FCD1EB616" modified="2004-10-25" version="1">MEREILKLKRSINAKHDEFLQALRDRDRAQQVADSGAGDTGAAAALQRQRAEMLGKAYLAGETADTEQIDREIEKLEAALREARKTQEGAAAAAALLEAKATTLLHEEGALRQQQAALARDLIQTRYDETKARYVEKVYGLISELQKLYALERGLEYFRGPNEPKPPLKLTEQLLIALRARGLCLPPGIEPNRYPDTTWDVHLPYVLDHDHHGEFAEKEVEALSQELRGYGFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S25</accession>
    <name>DADA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-amino acid dehydrogenase</fullName>
            <ecNumber evidence="1">1.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dadA</name>
        <name type="ordered locus">BPSL2497</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Oxidative deamination of D-amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18125"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DadA oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.99.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544221.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109092.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S25"/>
    <dbReference type="SMR" id="Q63S25"/>
    <dbReference type="STRING" id="272560.BPSL2497"/>
    <dbReference type="EnsemblBacteria" id="CAH36503">
        <property type="protein sequence ID" value="CAH36503"/>
        <property type="gene ID" value="BPSL2497"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2497"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2885"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDLYPRG"/>
    <dbReference type="UniPathway" id="UPA00043">
        <property type="reaction ID" value="UER00498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008718">
        <property type="term" value="F:D-amino-acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055130">
        <property type="term" value="P:D-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01202">
        <property type="entry name" value="DadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023080">
        <property type="entry name" value="DadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000066082" description="D-amino acid dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="3"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01202"/>
        </source>
    </evidence>
    <sequence length="428" mass="46233" checksum="BEC2462F61E5D243" modified="2004-10-25" version="1">MRVVILGSGVVGVASAYYLARAGHEVTVIDREAGPALDTSFANAGQISPGYAAPWAAPGVPLKAVKWMFEKHAPLAIRLDGTRFQLQWMWQMLRNCTTERYALNKGRMVRLAEYSRDCLQALRAETAIQYEGRTGGTLQVFRTQQQLDGAAKDIAVLREANVPFELLSSDELKKAEPALAAVSHKLTGGLRLPGDETGDCQLFTTRLAALAEQLGVKFRFNTRIDALAVAGGKIAGVQCGGEMVRADAYVVALGSYSTNLVASLVKIPVYPLKGYSITAPIVDAAKAPVSTVLDETYKIAITRFDDRIRVGGMAEIVGFDKRLRDARRGTLEMCVNDLFPGGGDTEKATFWTGLRPMTPDGTPIVGRTPVPNLFLNTGHGTLGWTMSCGSGQLLADLMSGKKPAIRADDLSVHRYLSETDGEHRPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SJ9</accession>
    <name>Q63SJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533957.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108917.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2321"/>
    <dbReference type="EnsemblBacteria" id="CAH36324">
        <property type="protein sequence ID" value="CAH36324"/>
        <property type="gene ID" value="BPSL2321"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2321"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3103"/>
    <dbReference type="eggNOG" id="COG2981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLIWGWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="277" mass="30490" checksum="EE8D18143AEE07A4" modified="2004-10-25" version="1">MNDLLRSFGRALASALHPRMLWLTFLPFIVSAVVWGVLLWFSWQPLVDAARAALDGFALTALLYKFFNAIGASQLHAVVAPFVVVSLAIPLIVLTVLLLIATLSMPAVVSHLSKRQFASLEMKRGGSLVGSVFNSLWAAFASIALLIVTVPLWLIPPFFALLPPVIWGWLTYRVMTYDALALHASAGERRALVRKHRWPLLGIGVASGLLGTVPTFIWVSSIWMMVLFPFVAAAMIWVYAFILVFSALWFGFYCLRALQDERAAAANAISTDSTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SM0</accession>
    <name>Q63SM0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pdhB</name>
        <name evidence="11" type="ordered locus">BPSL2300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="7">Binds 2 lipoyl cofactors covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Forms a 24-polypeptide structural core with octahedral symmetry.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205154.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108896.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63SM0"/>
    <dbReference type="STRING" id="272560.BPSL2300"/>
    <dbReference type="EnsemblBacteria" id="CAH36303">
        <property type="protein sequence ID" value="CAH36303"/>
        <property type="gene ID" value="BPSL2300"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2300"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3128"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006256">
        <property type="entry name" value="AcTrfase_Pyrv_DH_cplx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF2">
        <property type="entry name" value="PTHR43178:SF2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01348">
        <property type="entry name" value="PDHac_trf_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="117"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="546" mass="56296" checksum="1A845AFDE28FEC1E" modified="2004-10-25" version="1">MSQAIEVKVPDIGDYKDVPVIEVLVKPGDAVEPEQSLVTLESDKATMDVPSPSAGTVKEVKVKVGDAVSQGSLIVLLDGAQAAAQPAQANGAATSAAQPAAAPAAAPAPAAAAGGGTVDVKVPDIGDYKDVPVIEIAVKIGDTVEKEQSLVTLESDKATMDVPSPAAGVVKDIKVKVGDAVSEGSLIVVLEASGGAAASAPQAAAPAPAPAPAPAPAPQAAPAAAPAPAQAPAPAASGEYRASHASPSVRKFARELGVDVSRVTGTGPKSRITKDDVTAFVKGVMTGQRAAPGAAAAPAGGGELNLLPWPKVDFSKFGPFEAKPLSRIKKISGANLHRNWVMIPHVTNNDEADITELEALRVQLNKEHEKAGVKFTMLAFVIKAVVAALKKFPTFNASLDGDNLVFKQYYHIGFAADTPNGLVVPVIRDADKKGLVDIAKEMAELSKAAREGKLKPDQMQGGCFSISSLGGIGGTHFTPIINAPEVAILGLSRGQMKPVWDGKQFVPRLMLPLSLSYDHRVIDGAEAARFNAYLGALLADFRRIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SN2</accession>
    <name>Q63SN2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Iron-sulfur cluster assembly scaffold protein IscU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192918.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108884.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2288"/>
    <dbReference type="EnsemblBacteria" id="CAH36291">
        <property type="protein sequence ID" value="CAH36291"/>
        <property type="gene ID" value="BPSL2288"/>
    </dbReference>
    <dbReference type="GeneID" id="56596082"/>
    <dbReference type="KEGG" id="bps:BPSL2288"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3141"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKNPRNY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="14284" checksum="26036B8AA477AE35" modified="2004-10-25" version="1">MSYSNKVLDHYENPRNVGSFAKDDDTVGTGMVGAPACGDVMKLQIRVGADGVIEDAKFKTYGCGSAIASSSLVTEWVKGKTLDEALAIKNTQIAEELALPPVKIHCSILAEDAIKAAVADYKKRHETAEDGKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SW5</accession>
    <name>Q63SW5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108801.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36208">
        <property type="protein sequence ID" value="CAH36208"/>
        <property type="gene ID" value="BPSL2206"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2206"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2504"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="73" mass="7965" checksum="38029A8C2AAED7FC" modified="2004-10-25" version="1">MRMPALRLAAANQQIGESLNASPPAPVHTRERTGESIGKNGGEAWRKRVGKRNARRAKANGGLSERWTKRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SY2</accession>
    <name>Q63SY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193608.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108784.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2189"/>
    <dbReference type="EnsemblBacteria" id="CAH36191">
        <property type="protein sequence ID" value="CAH36191"/>
        <property type="gene ID" value="BPSL2189"/>
    </dbReference>
    <dbReference type="GeneID" id="56595972"/>
    <dbReference type="KEGG" id="bps:BPSL2189"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3260"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARITFFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="15621" checksum="4EE59C5613DE009D" modified="2004-10-25" version="1">MFKHILVPTDGSELSKKAIDGAIDLAQAVGARVTAYACLPQYPYSPFSEVVIEPPADFRERSEREARMHLDEVEAAARRAGVACESATSVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIVYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T24</accession>
    <name>LPXA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <shortName evidence="1">UDP-N-acetylglucosamine acyltransferase</shortName>
            <ecNumber evidence="1">2.3.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxA</name>
        <name type="ordered locus">BPSL2147</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:67812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="2.3.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family. LpxA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193051.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108742.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T24"/>
    <dbReference type="SMR" id="Q63T24"/>
    <dbReference type="STRING" id="272560.BPSL2147"/>
    <dbReference type="EnsemblBacteria" id="CAH36149">
        <property type="protein sequence ID" value="CAH36149"/>
        <property type="gene ID" value="BPSL2147"/>
    </dbReference>
    <dbReference type="GeneID" id="56595932"/>
    <dbReference type="KEGG" id="bps:BPSL2147"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3306"/>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECVTINR"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00387">
        <property type="entry name" value="LpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000013158" description="Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00387"/>
        </source>
    </evidence>
    <sequence length="262" mass="27941" checksum="70C4DC936E5933F6" modified="2004-10-25" version="1">MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRLVIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGGDGDAAVKSLVDFVESSQRGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TB1</accession>
    <name>Q63TB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108655.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2056"/>
    <dbReference type="EnsemblBacteria" id="CAH36057">
        <property type="protein sequence ID" value="CAH36057"/>
        <property type="gene ID" value="BPSL2056"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2056"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2320"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VENREYC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="132"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="855" mass="88867" checksum="DB24A137C47FF20E" modified="2004-10-25" version="1">MPTAPDAKPAPRRALAQAMPKRPGGGARTIVVNGPFERTGELESTGGTMRTIRMASIDVRLFIFGLLLFLSGLAHADTPSAAQPSPYGIVSVDIDGTRLCMEVGGAAVAPLAGVDVGECRQSADQQWSLVPNGQNFQVVAKHSLQCLTIANAATSPGAPLVQYPCNGGSNQQWSVSPSRSGYKLVSAHDALCASAAGASPGSRMVQQRCDEHASQTLYVSAPPELVGALIGMNGGLCIDGGAAGAQAVQRTCDDAPGQQWRIRPNGSAYKIHLASTNLCLGTRDASRGTGAAIESQRCANVASQLWTIRAASEVDGRNGYANGYWQFVSANSGQCIVVQNASTADGANLIQYPCGQGNAGSNTMWRVNRTSRSSWTGAIALPLVPSAAAHLPDGKILMWSADSTISFGGGGGGVDGNTYTTVFDPIAQKATDAVLTSLGHDMFCPGLNLLADGKIFVNGGVSSRKTSVYDPATHAWSPSNLMNIARGYQSSVTLSDGAVFTLGGSWNVATPDFRLGDKYGEVWRPDSGWSILSNVPDIIGPDPAGAYRGDNHMWLVAARDRWVFYAGPDATLRWIDTTGNGRIVEAGKRGDDAYSISGNAVMYDVGKVLTVGGAPAYDNGVASASAYVIDISAGPQVPPVVRKVQPLAYSRGFVNSVVLPNGQVVAIGGQAVTIPFSDDQSVLVPELWDPSTEAFTRLAPMTVPRNYHSEALLLPDGRVMASGGGLCGSGCNTNHPNVQILTPPYLLNADGTAASRPVIAAAPEQAANGSTIAVSTDAPIRSFALVRMSSSTHSVNTDQRRIPLTFRQSSGGDGGYAYTVAIPADAGVAIPGQYMLFALNAGGVPSVAKTIRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TC7</accession>
    <name>Q63TC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526757.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108639.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2042"/>
    <dbReference type="EnsemblBacteria" id="CAH36041">
        <property type="protein sequence ID" value="CAH36041"/>
        <property type="gene ID" value="BPSL2042"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2042"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2306"/>
    <dbReference type="OMA" id="MLNGLLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="11400" checksum="24FFAC6766BD142B" modified="2004-10-25" version="1">MLNGLLMNFGTDVFRFSRRPTTSLAPVFAHARVRATTAHESTEHVERQERQALRIWRAPAVDESSALPRIDEQPALRAASARRAAPQHLDPRRENVARGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TD7</accession>
    <name>Q63TD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196705.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108629.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2032"/>
    <dbReference type="EnsemblBacteria" id="CAH36031">
        <property type="protein sequence ID" value="CAH36031"/>
        <property type="gene ID" value="BPSL2032"/>
    </dbReference>
    <dbReference type="GeneID" id="56595360"/>
    <dbReference type="KEGG" id="bps:BPSL2032"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.12"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AIWPARS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="32178" checksum="0CD708700A9BB1FE" modified="2004-10-25" version="1">MESKHLRYFLAIADTGSLTHAAIRLGVAQPALSHALTKMERELGVKLFDRSRRGATLTTAGEAIVDDIRLSLARMDAAARRASEIGAQRAGRLSIGFVSAALFDTLPSAVCALRAASPRVDLVMREMSNAEQVVALERGEIDIGILHTPVAIGGPVHEKLIRRDPLIAVIPKSFPRQPDGSITLRELSRAGLIWFPHEQLPSIRAAILSAFRLAGHPIEVVQDANRTLTVIACVAAGCGVSLLPSSIRTLTFEGVDFSPVSDGHALPEFPLTAIWPKRSRRTLADRFAELLPRFQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TI6</accession>
    <name>Q63TI6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526815.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108580.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1982"/>
    <dbReference type="EnsemblBacteria" id="CAH35981">
        <property type="protein sequence ID" value="CAH35981"/>
        <property type="gene ID" value="BPSL1982"/>
    </dbReference>
    <dbReference type="GeneID" id="56595415"/>
    <dbReference type="KEGG" id="bps:BPSL1982"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4134"/>
    <dbReference type="eggNOG" id="ENOG5031611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRKEWAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266571" evidence="1">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4136" evidence="2">
        <location>
            <begin position="34"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="205" mass="21119" checksum="2448FDE55F748C58" modified="2004-10-25" version="1">MKVLWTGAALAAALLSGCASVTTGVSASAAPGALAGARTYDFARTATQAGNADYRRVETLVRGELAQRGFEEAAGTQARYRVTIAYATQPASVALTMPGCGGAQQPACVAVDGPAPFGLPFAGTVYRHVLTLRFIERSSGGDAYRVSAAVQDRHPDALLAAPVLVRSALARVPFADGGGWLVETKKRDADDAMPGVVSVKPARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TZ3</accession>
    <name>Q63TZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009980542.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108423.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1824"/>
    <dbReference type="EnsemblBacteria" id="CAH35823">
        <property type="protein sequence ID" value="CAH35823"/>
        <property type="gene ID" value="BPSL1824"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1824"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3947"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WKDYFFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267557" evidence="1">
        <location>
            <begin position="33"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="37471" checksum="B4B0DB441452C418" modified="2004-10-25" version="1">MTRASSLGRRLLSLTAALAVLVAALAAASLVAAPAARAEGRIRVAEQFGIVYLLLNVARDRHLIEQAGRAEGIAIDVDWVKLSGGAAINDALLSGSIDIAGAGVGPLLTIWDRTRGRQNVKGVASLGNLPYYLVSNDPRVKTIADFTARERIAVPAVTVSVQSRLLQFAAAQRWGDRAYDRLDKLTQAVAHPDAAAAIIAGRTELTAHFGNPPFQEQELAANPNAHIVLSSYDVLGGPSSATVLYATERFRRDNPKTYRAFVAALGQAARYVQTNPEGAVDAYLRVNGSKADRALLLKIVRNPQVQFRIAPQNTFALAAFMHRVGAIRHEPKTWRDYFFDDPATAQGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U73</accession>
    <name>ARCA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine deiminase</fullName>
            <shortName evidence="1">ADI</shortName>
            <ecNumber evidence="1">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginine dihydrolase</fullName>
            <shortName evidence="1">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arcA</name>
        <name type="ordered locus">BPSL1743</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526983.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108343.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63U73"/>
    <dbReference type="SMR" id="Q63U73"/>
    <dbReference type="STRING" id="272560.BPSL1743"/>
    <dbReference type="EnsemblBacteria" id="CAH35742">
        <property type="protein sequence ID" value="CAH35742"/>
        <property type="gene ID" value="BPSL1743"/>
    </dbReference>
    <dbReference type="GeneID" id="56595528"/>
    <dbReference type="KEGG" id="bps:BPSL1743"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3842"/>
    <dbReference type="eggNOG" id="COG2235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SAWIYDG"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01078">
        <property type="entry name" value="arcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182207" description="Arginine deiminase">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="1">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <sequence length="418" mass="46052" checksum="BD093EE12D6B9871" modified="2004-10-25" version="1">MSQAIPQVGVHSEVGKLRKVLVCSPGLAHQRLTPSNCDELLFDDVMWVNQAKRDHFDFVSKMRERGVEVLEMHNLLTETVQNPAALKWILDRKITPDNVGIGLVDEVRAWLEGLEPRALAEFLIGGVAASDIAGAERSKVLTLFRDYLGKSSFVLPPLPNMMFTRDTSCWIYGGVTLNPMHWPARRQETLLVAAVYKFHPAFTDAKFDVWYGDPDRDHGMATLEGGDVMPIGRGVVLVGMGERTSRQAVGQLAQALFAKGAAERVIVAGLPNSRASMHLDTVFSFCDRDLVTVFPEVVNRIVPFTLRPGGDARYGIDIEREDKPFVDVVAQALGLKSLRVVETGGNDFAAEREQWDDGNNMVCIEPGVVVGYDRNTYTNTLLRKAGVEVITIGSSELGRGRGGGHCMTCPVLRDPVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB8</accession>
    <name>Q63UB8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0276 protein BPSL1691</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0276 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534478.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108298.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1691"/>
    <dbReference type="DNASU" id="3091628"/>
    <dbReference type="EnsemblBacteria" id="CAH35690">
        <property type="protein sequence ID" value="CAH35690"/>
        <property type="gene ID" value="BPSL1691"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1691"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3771"/>
    <dbReference type="eggNOG" id="COG3220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWDTDVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00697">
        <property type="entry name" value="UPF0276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="303" mass="32849" checksum="F8DFC80CC5DBA6E1" modified="2004-10-25" version="1">MSDSVSIAKYMHRDCLHCPAPLVGTSFKPCHFADIVDNGLQDGFFEVHAENYMGKGGPPHRALSALRETYPVSVHGVCLSIGGPSPLDAHHLARFRDVVARYEPVLVSEHLAWSSHGGAFYNDLLPLPYTKATLDRVCAHVDQIQEAIARPLLLENPSTYVGFASSTMSETEFIAAVAGRTGCGLLLDINNAFVSATNHGCSAADYLADFPLEQVGEIHLAGHSEQRDDEDEPLLIDSHDRPIAGPVWALYASVIARTGPVPTLVEWDSQLPDWLVLRAQALEARRIMDAAVASPVEVADHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UJ4</accession>
    <name>Q63UJ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative copper-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550379.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108222.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1606"/>
    <dbReference type="EnsemblBacteria" id="CAH35606">
        <property type="protein sequence ID" value="CAH35606"/>
        <property type="gene ID" value="BPSL1606"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1606"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3665"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYGLHFM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026464">
        <property type="entry name" value="NosD_copper_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04247">
        <property type="entry name" value="NosD_copper_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267582" evidence="1">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="40"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="416" mass="45780" checksum="5D6659D23E7D04C7" modified="2004-10-25" version="1">MPIPHALATLAAAALLMHAACAATLAVHPGERIGAALAAARPGDTVLVQHGRYEENLRIDKPLTLRGVGRPTIDGRLAGDVIRVAAPDVTISGFSIVDSGASLTAQNAGVYVAPGSDRARIERCELVYNLFGLWIERSADVRVTGNVIVGKRDLLSPRRGNGIQLYNTTGARIAGNTISYTRDGIYVDVSHHARFEHNTIHDVRYGTHYMNSYYNVWDGNDVYHNRGGLAIMEARDQIVRGNRVWGNTDHGIMLRTIQDSLIENNVVAGNQRGLFIYDAEYNTIRGNLVVDNKIGVHLWGGSIHNDVTGNDFADNREQIRYVAASDVAWPGNYWSNYLGWDRRGRGVGDVPYKANDLVDRLTWRVPSVKVLMNSPAVQALRVVARQFPLLAVPSVVDDAPRMRAVHAGWPQWVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UW6</accession>
    <name>Q63UW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaD</name>
        <name evidence="1" type="ordered locus">BPSL1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193789.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108100.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1480"/>
    <dbReference type="EnsemblBacteria" id="CAH35481">
        <property type="protein sequence ID" value="CAH35481"/>
        <property type="gene ID" value="BPSL1480"/>
    </dbReference>
    <dbReference type="GeneID" id="56595783"/>
    <dbReference type="KEGG" id="bps:BPSL1480"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3512"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRVHAKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="85" mass="8969" checksum="E4E28C85E2A2E01A" modified="2004-10-25" version="1">MKIELKFFASVREALGVASETVTVPDGVATVGDVRAWLRARGGAWADTLAEGRALRMACNHTMTDAGTRITEGCEVAFFPPVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V57</accession>
    <name>Q63V57_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imm52 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521809.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108009.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1385"/>
    <dbReference type="DNASU" id="3094348"/>
    <dbReference type="EnsemblBacteria" id="CAH35386">
        <property type="protein sequence ID" value="CAH35386"/>
        <property type="gene ID" value="BPSL1385"/>
    </dbReference>
    <dbReference type="GeneID" id="56526454"/>
    <dbReference type="KEGG" id="bps:BPSL1385"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.90"/>
    <dbReference type="eggNOG" id="ENOG5032WXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QEDATRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028969">
        <property type="entry name" value="Imm52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016929">
        <property type="entry name" value="UCP029636"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15579">
        <property type="entry name" value="Imm52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029636">
        <property type="entry name" value="UCP029636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Imm52" evidence="1">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="26220" checksum="EBB4D7C4EC6329F0" modified="2004-10-25" version="1">MNITASFRDASLVAFDFPEILTRISKIIDALKAHDDSLRYENWMLKGDNQEDATRYHVYDAAGIATPAALAVLREEFRNSKDFTYVAMWDGNLASDNGASISCHVGDKSLPDTLTLRIEGERWKAYAAISGIVSTMVTIFSPALVEVSFDEYAVKQVFDDKPGVGWMLYLPKVITQQQVPEARALIPVPAKGKQTGTIIISVTDAPFSVDNPEHVAIANRIEIRLVDQDLLPAYVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VA8</accession>
    <name>Q63VA8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative malonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1333"/>
    <dbReference type="EnsemblBacteria" id="CAH35331">
        <property type="protein sequence ID" value="CAH35331"/>
        <property type="gene ID" value="BPSL1333"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1333"/>
    <dbReference type="eggNOG" id="ENOG5032T8X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGVNWRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017557">
        <property type="entry name" value="Holo-ACP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10620">
        <property type="entry name" value="MdcG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03135">
        <property type="entry name" value="malonate_mdcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="31113" checksum="0C7DE56EAEECF7F5" modified="2004-10-25" version="1">MRHTLVRVRAQAWPALLAAHGGIGTLPFVRDWAARGWPLIVRRRSPCDAGVPLGLPLPPSAGKRRVALAAAREQIDSACALPTLADVGRQAPPAWRPTLARLRALADAHRVDCRVFGSLAWQTLTGLRYLSDESDLDVLLMPCGASSSASLFRFSSSFASSFASVSVSPSSPSVSIPQSSRAWPVPALAGASSSAAVTGAEASAPMTAQMEASASRLSRWPGSSSMPSRRDAIAPFLAALAEIDADAPMRIDGELLCADGAGVNWRELHAGGRAVAMKTATGVELVAPRTFLEAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VE5</accession>
    <name>Q63VE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclic nucleotide phosphodiesterase class-III family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107921.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1299"/>
    <dbReference type="EnsemblBacteria" id="CAH35294">
        <property type="protein sequence ID" value="CAH35294"/>
        <property type="gene ID" value="BPSL1299"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1299"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1445"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGIGHMD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07402">
        <property type="entry name" value="MPP_GpdQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026575">
        <property type="entry name" value="GpdQ/CpdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042281">
        <property type="entry name" value="GpdQ_beta-strand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042283">
        <property type="entry name" value="GpdQ_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="29659" checksum="AD50A632A6FCCE80" modified="2004-10-25" version="1">MMLLAHISDLHIKRPGALAYRRVDTAAHLARCVARLNALEPRPDAVLVTGDLTDFGDDDEYAHLKALLAPLAMPYYLLVGNHDDRAALRRAFPARVELQSGEFVQYALDLGPLRVIALDSQIPGASGGTLCDARLAWLAGQLDAARDRPVIVALHHPPFACGIGHMDAMRLAPDASSRLDALLRRHPNVERVLCGHVHRTMFARFGGTIASAVPAPAHQVTFDLRDGGPSSFSMEPPAFAVHRHAPGAGLASHHVYVDASDGPHPFFEPTGTLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VI5</accession>
    <name>Q63VI5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536008.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107881.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1260"/>
    <dbReference type="EnsemblBacteria" id="CAH35254">
        <property type="protein sequence ID" value="CAH35254"/>
        <property type="gene ID" value="BPSL1260"/>
    </dbReference>
    <dbReference type="GeneID" id="56526598"/>
    <dbReference type="KEGG" id="bps:BPSL1260"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.258"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVYFWLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01660">
        <property type="entry name" value="ba3-like_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033943">
        <property type="entry name" value="Ba3-like_Oxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="541" mass="59466" checksum="B5F55E798FB2D1FD" modified="2004-10-25" version="1">MLKNNRLVLAHFWLAFAVFGVALLLGAWQMLARSPLHPWLGNPELYYRSVTAHGSVMGYVFPTLIAMGFGYAISELALKMPLVGRRWAWTGFWLIGLGSVVAMTPVSLGLSSVLYTFYPPMIGSPFYYLGVVLVVVGSWIWVALMSVNLYAWKKRNPGTPIPLAMFANVAGAYLWGWTAVGAAIEILFQILPVAVGLKTTIDAGLARVFFSWTLHAIVYFWLIPAYIAYYTLVPRAIGGKLYSDGMARISFILFLVGAMPIGVHHLFADPQVGSGFKFLQSVFTALVAVPTLLTVFTVCASVEIAARLRGGKGAFGWLRALPWHEPMMLAVAFSFVMLGFGGAGGLINMSYQLDSTIHNTQWITGHFHLIFGGAVVIMYFAIAYELWPHLTGRALGSLRLVKAQLWLWFIGMIVTTFPWHYVGILGMPRRMAYYDYSDPALAPQAAWVIMSVVGALILVASAVLFFVVLLRSHCGVKVKPAEFAFSSAVHEPKTLPVALNSFGLWIALMIGLTVVNYGYPIAQLMSLKQPSVPAIYMGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VI8</accession>
    <name>Q63VI8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL1257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="8">Binds 3 heme c groups covalently per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Binds 3 heme groups per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538457.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107878.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1257"/>
    <dbReference type="EnsemblBacteria" id="CAH35251">
        <property type="protein sequence ID" value="CAH35251"/>
        <property type="gene ID" value="BPSL1257"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1257"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.261"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYIRTAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014353">
        <property type="entry name" value="Membr-bd_ADH_cyt_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000018">
        <property type="entry name" value="Mb_ADH_cyt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267192" evidence="11">
        <location>
            <begin position="37"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="188"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="319"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000018-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000018-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="45861" checksum="5E6AED2E6C4C4BD5" modified="2004-10-25" version="1">MEASVHKHLIVKFRSACANAALGLLAATLAASAAHAQPAADAATLKRGEYLARAGDCVACHTVPGEKLFAGGRAMPTPFGTLYSPNITPDNDAGIGKWTADEFYTMMHTGRSRDGSLLYPAMPFAAYTKVTRADSDAIFAYLRSVPPVKLANRPHDMRFPYNNRQLLIGWRTLYFKEGEYQPDHTKSAEWNRGAYLVQGLGHCSMCHTAINALGGSSEANAFEGGLIPMQAWYAPSLTSNKEAGLGDWSIADITGLLQAGASHRGAVYGPMAEVVYDSLQYLSDDDVRAMSVYLKSLPQRGSDAESAPKTTMAASEQARLSKLGAKIYDAQCASCHGKTGRGKTPAFPPLAGNQSIQMTSAVNPIRMVLNGGYAPGTAKNPEPYGMPPFAQSLSDDEVAAVTTFIRTAWGNRGAPVSAKEANALRSAPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VJ6</accession>
    <name>Q63VJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550696.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107870.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1249"/>
    <dbReference type="EnsemblBacteria" id="CAH35243">
        <property type="protein sequence ID" value="CAH35243"/>
        <property type="gene ID" value="BPSL1249"/>
    </dbReference>
    <dbReference type="GeneID" id="56526608"/>
    <dbReference type="KEGG" id="bps:BPSL1249"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.275"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANFSHAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="246"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="347" mass="38892" checksum="BE94F30C2973830B" modified="2004-10-25" version="1">MATSVPDPTRQLNKATVSSAYALFMLMLAEERGIADADLLAHTGVTRTKLEEPNARITPLQQAAIVFNLLGMTNDPSIAIEIGLRSSLTKSGLIGFGLMSCATLGEAIQLGIRYLPTRVPFFSVRFTEFEHTVQIDILEAFPLGRLRQFAVENFMVETAILFNSLLTPSHDKTMKANAELCFEWPEPPYFARYRDRLPRCHFGAPANQIRCEAALLDEPIKTANAHTAQMIVQQCEAELARLGYAESIVERVRNLLIRGSHGYPSLDALARELHLSERTLKRKLSDYGTTYSALLDEIRLRDALRLLEGTTLTVEEIAARVGYTDRANFSRAFRRWTGTSPSDRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL6</accession>
    <name>Q63VL6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185551.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107850.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1228"/>
    <dbReference type="EnsemblBacteria" id="CAH35223">
        <property type="protein sequence ID" value="CAH35223"/>
        <property type="gene ID" value="BPSL1228"/>
    </dbReference>
    <dbReference type="GeneID" id="56595162"/>
    <dbReference type="KEGG" id="bps:BPSL1228"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.298"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TVRPIIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="231"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="398" mass="44374" checksum="9ED3BDAEF8080502" modified="2004-10-25" version="1">MDLDYSPADDAFRAEIRAWLEANLPRALRDKVLNHKRLNRDDFAGWHRLLGTRGWSAPAWPAEYGGPGWNATQRHIWEEECARIGAPPVLPFGVSMVAPVLMKYGSEAQKRRYLPRILDGTDWWCQGYSEPGSGSDLASLRTRAERRGDHYLVNGQKTWTTLGQHADMMFCLVRTDPDAKKQEGISFLLIDMKSPGITVRPIVTLDEDREVNEVFFEDVKVPVENLVGDENRGWTYAKYLLGHERTGIARVGASKRELDFLKRIASRERKNGKPLIADPVFAAKIAALEIELMALEVTVLRVVSSEASGRGPGPEASMLKIKGTEIQQALTELMVDAIGPLAAPFDAAFLEGERERSIAGDDDAAPLAAYYFNYRKTSIYGGSNEIQKNIIAQMILGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB9</accession>
    <name>ILVD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="1">DAD</shortName>
            <ecNumber evidence="1">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ilvD</name>
        <name type="ordered locus">BPSL0969</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191611.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107597.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WB9"/>
    <dbReference type="SMR" id="Q63WB9"/>
    <dbReference type="STRING" id="272560.BPSL0969"/>
    <dbReference type="EnsemblBacteria" id="CAH34965">
        <property type="protein sequence ID" value="CAH34965"/>
        <property type="gene ID" value="BPSL0969"/>
    </dbReference>
    <dbReference type="GeneID" id="56596222"/>
    <dbReference type="KEGG" id="bps:BPSL0969"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.607"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NCDKNVP"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225377" description="Dihydroxy-acid dehydratase">
        <location>
            <begin position="1"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <sequence length="557" mass="59039" checksum="E0241EFAED50F00D" modified="2004-10-25" version="1">MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTIVSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLVEAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGDCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMVVGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WF2</accession>
    <name>Q63WF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydrodipicolinate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186540.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107564.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0936"/>
    <dbReference type="EnsemblBacteria" id="CAH34931">
        <property type="protein sequence ID" value="CAH34931"/>
        <property type="gene ID" value="BPSL0936"/>
    </dbReference>
    <dbReference type="GeneID" id="56595026"/>
    <dbReference type="KEGG" id="bps:BPSL0936"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.644"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPPMRYK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="31545" checksum="AFDDB12191300353" modified="2004-10-25" version="1">MSNLLQGIIAYPVTPFSPDGRLDTAALGALIERLIASGVHGIAPLGSTGESAYLSDAEWEAAASASIRAVERRVPTVVGISDLTTANAVRRAKFAEQAGADAVMVLPVSYWRLDDEAIVGHYRAIGDAIGIPIMLYNNPATSGIDMSPELIARIFRTVDNVTMVKESTGDIKRMHRLAQLGDGAIPFYNGSNPMALAALAAGAAGWCTAAPNLNARLPLALYDAMRASDLDTARAVFHRQLPLLQFIVSGGLPVTVKAGLRLAGFDAGEPRKPLRPLDEARTRELAAILDALRDTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WG3</accession>
    <name>Q63WG3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531989.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107553.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0925"/>
    <dbReference type="EnsemblBacteria" id="CAH34920">
        <property type="protein sequence ID" value="CAH34920"/>
        <property type="gene ID" value="BPSL0925"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0925"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.655"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IAGFDGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="16516" checksum="A5D50D069A79FB41" modified="2004-10-25" version="1">MSTAIVSDDIAIRPFARADTDAALAVWRDAFPSYSDASTPHRDPRRAIELKLATQPELFFVATAGGRVVGTVMAGYDGHRGWLYSLAVERGARRLGIGRALLAHAEAALAERGCPKVNLQVLPGNDDACRFYEALGYHEEARISFGKRLATD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WJ7</accession>
    <name>EFG1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G 1</fullName>
            <shortName evidence="1">EF-G 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA1</name>
        <name type="ordered locus">BPSL0893</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197486.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107519.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WJ7"/>
    <dbReference type="SMR" id="Q63WJ7"/>
    <dbReference type="STRING" id="272560.BPSL0893"/>
    <dbReference type="EnsemblBacteria" id="CAH34886">
        <property type="protein sequence ID" value="CAH34886"/>
        <property type="gene ID" value="BPSL0893"/>
    </dbReference>
    <dbReference type="GeneID" id="56594729"/>
    <dbReference type="KEGG" id="bps:BPSL0893"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.691"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091095" description="Elongation factor G 1">
        <location>
            <begin position="1"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="8"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="704" mass="77808" checksum="5AECC16F893638D2" modified="2004-10-25" version="1">MPRKTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWKGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYKVPRIAFVNKMDRVGADFFRVQRQIGERLKGVAVPIQIPVGAEEHFQGVVDLVKMKAIVWDDESQGVKFTYEDIPANLVELAHEWREKMVEAAAEASEELLEKYLTDHNSLTEDEIKAALRKRTIANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAILGHDLDDKEAERHPSDDEPFSALAFKIMTDPFVGQLIFFRVYSGVVESGDTLLNATKDKKERLGRILQMHANERKEIKEVRAGDIAAAVGLKEATTGDTLCDPGKPIILEKMEFPEPVISQAVEPKTKADQEKMGLALNRLAQEDPSFRVQTDEESGQTIISGMGELHLEIIVDRMKREFGVEATVGKPQVAYRETVRTVAEDVEGKFVKQSGGRGQYGHAVIKLEPNPGKGYEFLDEIKGGVIPREFIPAVNKGIEETLKSGVLAGYPVVDVKVHLTFGSYHDVDSNENAFRMAGSMAFKEAMRRAKPVLLEPMMAVEVETPEDFMGNVMGDLSSRRGIVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSATQGRATYTMEFKHYAETPSNVSEAVINAKQVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WN1</accession>
    <name>Q63WN1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189096.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107485.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0860"/>
    <dbReference type="EnsemblBacteria" id="CAH34852">
        <property type="protein sequence ID" value="CAH34852"/>
        <property type="gene ID" value="BPSL0860"/>
    </dbReference>
    <dbReference type="GeneID" id="56596502"/>
    <dbReference type="KEGG" id="bps:BPSL0860"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.737"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="184" mass="19660" checksum="990F0C6BCBBB7D2F" modified="2004-10-25" version="1">MPEQPSHAHAAPPLPAPLAERTLALADEAATIALGERLAHALDAMRGARAAAHAFDGLQIQLYGDLGAGKTTLVRAMLRGLGHAGRVKSPTYTLVEPYALARSDGELEVYHFDLYRFSDPAEWADAGFREYFNSGAICIVEWPQRAGALLGVPDLVFSLDVAGEGRLLTARAYSASGKACLERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WS1</accession>
    <name>Q63WS1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fghA</name>
        <name evidence="8" type="ordered locus">BPSL0821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + S-formylglutathione = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526232.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107445.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0821"/>
    <dbReference type="ESTHER" id="burma-q62mc3">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.940"/>
    <dbReference type="EnsemblBacteria" id="CAH34812">
        <property type="protein sequence ID" value="CAH34812"/>
        <property type="gene ID" value="BPSL0821"/>
    </dbReference>
    <dbReference type="GeneID" id="56527000"/>
    <dbReference type="KEGG" id="bps:BPSL0821"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.781"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFMEDHL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="PTHR10061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="286" mass="30953" checksum="4737F6020C5267C3" modified="2004-10-25" version="1">METTTLECVSSHACHGGEQRFYRHESKTIGLPMKFSAYLPPQAAHGRVPALFYLAGLTCTEETFAIKAGAQRFAAQHGIALVAPDTSPRGAGVPGEADAWDFGVGAGFYVDATEAPWSAHYRMESYVSGELREIVAAELPIDAARLGIFGHSMGGHGALVLALRHPQLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADREAWKRHDASELVARADAKRFAEGILIDQGLADPFLPTQLHPDAFEAACRAAGQPLTLRRHAGYDHGYYFISTFIADHLAHHARVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WT9</accession>
    <name>Q63WT9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188980.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107427.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0802"/>
    <dbReference type="EnsemblBacteria" id="CAH34794">
        <property type="protein sequence ID" value="CAH34794"/>
        <property type="gene ID" value="BPSL0802"/>
    </dbReference>
    <dbReference type="GeneID" id="56596563"/>
    <dbReference type="KEGG" id="bps:BPSL0802"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.802"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="35554" checksum="257C797B1BCB2593" modified="2004-10-25" version="1">MSNDRPFPSAEAIEDAAARLDAGELVAFPTETVYGLGADAQNPAAVARIYAAKGRPANHPVIVHLAPGSDPGYWVEALPADAKKLIDAFWPGPLTLILKRATHIPDAVSGGQDSVGLRCPSHPVAQALLRAFDARRGGHGGVAAPSANRFGHVSPTTAQHVRDEFGDAVHVLDGGPSDVGIESTILDLSRGFPALLRPGHVSPRQIADVLGVAPRLPDGSDATAPRASGTLKAHYAPRTPLALAAFERLEPLLAAARDTGEPVALVARASRAGAWAHAAGVHFVAAPEDPAAYARELYGLLRALDRAQVARILVEKLPDTAEWTAVNDRLGRAAAAFDAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X38</accession>
    <name>Q63X38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative galactonate dehydratase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526152.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107328.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0699"/>
    <dbReference type="EnsemblBacteria" id="CAH34692">
        <property type="protein sequence ID" value="CAH34692"/>
        <property type="gene ID" value="BPSL0699"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0699"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.918"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRWCFLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="125"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="382" mass="42222" checksum="0693593295F30CBD" modified="2004-10-25" version="1">MKITRLETFVVPPRWLFLKIETDAGIVGWGEPIVEGRAHTVEAAVHELADYLVGQDPLRIEDHWQVMYRAGFYRGGPITMSAIAGIDQALWDIKGKHHGAPVHALLGGPVRERIKVYSWIGGDRPSDVANNARAVVERGFQAVKMNGSEELQIVDTFDKVDKVIANVAAVRDAVGPYVGIGVDFHGRVHKPMAKVLARELDPYKLMFIEEPVLSENAEALRDIANQTSTPIALGERLYSRWDFKRILEGGYVDIVQPDASHAGGITECRKIATLAESYDVALALHCPLGPIALAACLQLDAVSYNAFIQEQSLGIHYNQGSDLLDYLRNPDVFRYADGFVAIPQGPGLGIDVDEDKVCEMAKTGHRWRNPVWRHADGSVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XA9</accession>
    <name>Q63XA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family C56 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526116.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107256.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0627"/>
    <dbReference type="MEROPS" id="C56.A06"/>
    <dbReference type="EnsemblBacteria" id="CAH34620">
        <property type="protein sequence ID" value="CAH34620"/>
        <property type="gene ID" value="BPSL0627"/>
    </dbReference>
    <dbReference type="GeneID" id="56527163"/>
    <dbReference type="KEGG" id="bps:BPSL0627"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.997"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAWMREF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="193" mass="20597" checksum="897CB6CA19787E16" modified="2004-10-25" version="1">MAAKKILFLTGDFAEDYETMVPFQALLAIGHHVDAVCPGKRAGEKVKTAIHDFEGDQTYTEKPGHQFTLNATFDEADATGYDALAIAGGRAPEYLRLDPKVIALVRAFAEAKKPIAAICHAAQLLAAADVIRGKRISAYPACAPEVRLAGGEFADIPVDAAVTDAPFVTAPAWPAHPAWLSQFLALLGTRIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XB9</accession>
    <name>Q63XB9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH crp-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107246.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63XB9"/>
    <dbReference type="STRING" id="272560.BPSL0617"/>
    <dbReference type="EnsemblBacteria" id="CAH34610">
        <property type="protein sequence ID" value="CAH34610"/>
        <property type="gene ID" value="BPSL0617"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0617"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.670"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RRVCECY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="288" mass="31800" checksum="691EE26C51943EA2" modified="2004-10-25" version="1">MRNGILRRGRAAPTNRDTNMLHQNNGFHANALLGSLADDSLRALAPHLELVKIKSAQLLCETDEPMRHLYFPTTAMMSVLYLMEDGAMVEVAAVGSEGVVGVSTLADYACGGASGRIEVRSGGYAYRVPTQVFRREFDRSIDTFQLMLRYWQAAMTQIARGALCNRHHSVSEQLSRWLLLAHDRVEGDELAVTQQTIANMLGVRREGITEAAGKLQEAGLIRQRRGHITVLDREGLEARACECYGVIRGEFNRLILEARRDAHAPQPIPAEGRPLRVAGYHGAVRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XI5</accession>
    <name>Q63XI5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936261.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107180.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0555"/>
    <dbReference type="EnsemblBacteria" id="CAH34544">
        <property type="protein sequence ID" value="CAH34544"/>
        <property type="gene ID" value="BPSL0555"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0555"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1092"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHVMGNN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="31977" checksum="2A23A038F1B93AB5" modified="2004-10-25" version="1">MPAYHYQTPTNDKEGSRHDVTGHLMPARAFFFAIVDEPGKDGFLVRKIYAAPDNVFLRDMGLSPLQQLQELHPEKYGLSPKSFEAGTSVAEHVMGNNMSSYVSTSELFPGGSPRFEGRSIVIDIAKAKRAGAKLVQTDEILTALEQYKAENPHLAKRVSKIAGYVKDIDKEVLVQSPKVPASAIFNERSLRTALGFTKYARVVQIFGIVFTAYDLDVAAEQSVQTKSIRPIRREAVRQMGGWSGATAGARIGAALGASIGVETGPGAIITGAIGGLLFGAVGYFGADWLNNKFDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XI6</accession>
    <name>Q63XI6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107179.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0554"/>
    <dbReference type="EnsemblBacteria" id="CAH34543">
        <property type="protein sequence ID" value="CAH34543"/>
        <property type="gene ID" value="BPSL0554"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0554"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1093"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DIVLCGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="19672" checksum="5EDE3C73228AB8AB" modified="2004-10-25" version="1">MKRNMLVLGDRTTAGGIVQEGVAAGFNNGTPLAYHGALVHCPTCKSDGHIVGAGPSWPMTFDGKQVALENDLCVCKCDPPPRMIASKNDMFMTFEGHQLAQMGYAADGSPLSDQAMHAFDEQVRILDEHGEPLANVPYHIRDQSGNEYQGLTDEDGLCPRVSTASIETLSIAVGVAALEKWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XJ7</accession>
    <name>Q63XJ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purU</name>
        <name evidence="5" type="ordered locus">BPSL0543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522850.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107168.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0543"/>
    <dbReference type="EnsemblBacteria" id="CAH34532">
        <property type="protein sequence ID" value="CAH34532"/>
        <property type="gene ID" value="BPSL0543"/>
    </dbReference>
    <dbReference type="GeneID" id="56527211"/>
    <dbReference type="KEGG" id="bps:BPSL0543"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1105"/>
    <dbReference type="eggNOG" id="COG0788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HADHHTD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="293" mass="32245" checksum="483F40B339C9248F" modified="2004-10-25" version="1">MPADHSFILKLSCPDRRGIVHAVSGFLLERGSNILDSAQFGDSRTGEFFMRVHFEQAGACGAAAALDALRAEFAPLAEAFAMRWELHDAAVKPRVVILVSKIGHCLNDLLFRYRTGQLPIEISAIVSNHKDFYQLAASYDIPFHHLPLAAGASADAKAAQEARVLEVIDGHAADLVVLARYMQILSPALCERLAGRAINIHHSFLPSFKGAKPYYQAFDRGVKLIGATAHYVTTDLDEGPIIEQEVERVDHSMTPDELTAVGRDVECVTLARAVKWHVEHRIVLNGTKTVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XN1</accession>
    <name>Q63XN1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107134.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0508"/>
    <dbReference type="EnsemblBacteria" id="CAH34498">
        <property type="protein sequence ID" value="CAH34498"/>
        <property type="gene ID" value="BPSL0508"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0508"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.570"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LAEHACH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="29971" checksum="5F738BD5F4F46335" modified="2004-10-25" version="1">MSPDQPRESMQQIAVLLDGMIKKNAYLPRRIGGTMRVDEQPGYAIVDSGLPTDTFNLVIGKAHGQPDAAAIARIAARFNDAGLPAAWWTCRDLTDAAFARALGEAGFVADETSVGMLAELDALPPVAPPPGFGVRQINAQHDVAHFGTLIGALFDPPDAFVDAFYARVAALDFDAAEPLKLFVGELDGRPVSTTALYVDADTAHVFDVSTSAGQRKRGLASAIMHSALVHARERLGATRAALQASPDGLNVYRRLGFRAVCEFQVYSNRAAASPRGELGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XQ6</accession>
    <name>Q63XQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204805.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107109.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0484"/>
    <dbReference type="EnsemblBacteria" id="CAH34473">
        <property type="protein sequence ID" value="CAH34473"/>
        <property type="gene ID" value="BPSL0484"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0484"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1171"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QHEASGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="346" mass="36179" checksum="3148579E899F8655" modified="2004-10-25" version="1">MLTIHHTAIRQPSRRSVDAAQASGRYRYDGRLAPHAIRFAMPYERLDYDTHTFAHLARPAPASLPVETRGRTLSDLALEAVRDVVGAAGPGACASISQIVVAQASLNEHAGESVAGRMQHALGLKHIVPFALGQCGTLGLHAALPLAHGLLRDGGRMLFVAADKWVYPFLRTYGEFVAYGDGAAAILLGHAETDAEADAAQARVLGHALAHGEPIADPWARQPAELERALVAPTVDAARAALADAGVGAARIDCFAPGGFSASFRTTLARALAIPPSRLQVRDGVEHLSTADTPRALAQAQASLAPGERRLALFCDTALAGGAGALVAQLRGAHASSSSTRTRYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y35</accession>
    <name>Q63Y35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522971.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106980.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0354"/>
    <dbReference type="EnsemblBacteria" id="CAH34342">
        <property type="protein sequence ID" value="CAH34342"/>
        <property type="gene ID" value="BPSL0354"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0354"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1322"/>
    <dbReference type="eggNOG" id="ENOG5033ZK4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHGVDGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267266" evidence="1">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="134" mass="13765" checksum="37B82B5D5B2B80E3" modified="2004-10-25" version="1">MFKILQSRRVVTAAAFALAAAYSVGVPAETVQAVSSVAPLHGGVDGPFFPKAASAVPASASATTGAQLQQQAQSRLAASLGANGALRNGAALTKAQAQASGLGYVAQHFDEIDTARTGKVTLKQVQQFIEQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC0</accession>
    <name>Q63YC0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Anti-sigma-28 factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAH34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106895.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0268"/>
    <dbReference type="EnsemblBacteria" id="CAH34256">
        <property type="protein sequence ID" value="CAH34256"/>
        <property type="gene ID" value="BPSL0268"/>
    </dbReference>
    <dbReference type="GeneID" id="56594381"/>
    <dbReference type="KEGG" id="bps:BPSL0268"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1437"/>
    <dbReference type="eggNOG" id="COG2747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MKINHTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="10">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="114" mass="11119" checksum="20F325DF1024DE9B" modified="2004-10-25" version="1">MKVDSTPTSNARTLSNASAGAARTQAGQPAAAQTPAGAAGAPTGGDANVSLSGLSSTLRSLAASGSADIDTAQVDAIRDAIKSGTLSIDTGKIADGILQTARDLLKQPSQAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YH8</accession>
    <name>Q63YH8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106837.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0209"/>
    <dbReference type="EnsemblBacteria" id="CAH34196">
        <property type="protein sequence ID" value="CAH34196"/>
        <property type="gene ID" value="BPSL0209"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0209"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.222"/>
    <dbReference type="eggNOG" id="COG3159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FQVPFVS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007435">
        <property type="entry name" value="DUF484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38765">
        <property type="entry name" value="PTHR38765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04340">
        <property type="entry name" value="DUF484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="26430" checksum="A9B80C8CFDF329AB" modified="2004-10-25" version="1">MPKPERSAMNDREVADYLLANPEFFAQHAELLATIKLANPHGKAAVSLQERQMEMLREKNKHLERRLAELLRYGHENDGLAAKFNRWTARVIAERDPYALPRAIAGGLADVFDVPQTALRLWDVAETYAQADFARNVGEEVRLFTNSLATPYCGANTGFEAAQWLTPVAAPPAADDGEAPAASGAAESVALIALRASAEGEGAGAFGLLVLGSPDPRRFHDGMGTDFLTQIGTLASAALTRLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK6</accession>
    <name>Q63YK6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552446.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106809.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0181"/>
    <dbReference type="EnsemblBacteria" id="CAH34168">
        <property type="protein sequence ID" value="CAH34168"/>
        <property type="gene ID" value="BPSL0181"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0181"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1538"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYTRLEN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267705" evidence="1">
        <location>
            <begin position="41"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="26950" checksum="3D9F6CDADC18B753" modified="2004-10-25" version="1">MSGKRRGAPLSTRTPRVLLGAVIGSLAAAALGAAAGGALAQAPGAPSRPDPQRETEAAVADYNAGNLRAALVQFHDAAARGNRLAAFDYAMMLINGEGVTANVPEGLRWLRRAADAGMTQAQYVYGRMLDDGEFVARDPAAAHDWFLKAAQQGHVQAELALANQFLDGRGTPRDNRQAFAWYKRAADAGEPVSQYVTASFYERGGDGVVRNLDIARAYYAAAAAQGDDAAALKYRELTAAQKAGPGGASAPKATGPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM1</accession>
    <name>Q63YM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage tail protein X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0166</name>
        <name evidence="2" type="ordered locus">BPSS1069</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CAH38535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524438.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111080.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0166"/>
    <dbReference type="EnsemblBacteria" id="CAH34153">
        <property type="protein sequence ID" value="CAH34153"/>
        <property type="gene ID" value="BPSL0166"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38535">
        <property type="protein sequence ID" value="CAH38535"/>
        <property type="gene ID" value="BPSS1069"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0166"/>
    <dbReference type="KEGG" id="bps:BPSS1069"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1556"/>
    <dbReference type="eggNOG" id="COG5004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RETVQLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008861">
        <property type="entry name" value="GpX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05489">
        <property type="entry name" value="Phage_tail_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="68" mass="7296" checksum="3441F5626FB8A7A9" modified="2004-10-25" version="1">MKIAALQGETLDALCWRHYGSTAGTVEAVLEANPGLAELGVVLPMGTVVEMPERRAIETTTPLLQLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR2</accession>
    <name>Q63YR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188929.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106753.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0126"/>
    <dbReference type="EnsemblBacteria" id="CAH34112">
        <property type="protein sequence ID" value="CAH34112"/>
        <property type="gene ID" value="BPSL0126"/>
    </dbReference>
    <dbReference type="GeneID" id="56596705"/>
    <dbReference type="KEGG" id="bps:BPSL0126"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1596"/>
    <dbReference type="eggNOG" id="ENOG502ZZV8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WKRFTFT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025500">
        <property type="entry name" value="DUF4390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14334">
        <property type="entry name" value="DUF4390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266678" evidence="1">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="196" mass="22215" checksum="506121E5277FDD85" modified="2004-10-25" version="1">MTIKRFFPLRLAAVLWVALTLCLAAVPAARADTIAVQRASLQSDGSGWSLDARFDFELNSSLEDAVNKGVPLYFTTDFELSRARWYWFDEQPVSVSQTIRLSFQPLTREYRVSTGGLQLGFPSLKEALAVVKHVTSWHVIDKGQVRPGETYTASVRMQLDTALMPKPFQVDAVNNRDWNLVSDWKRFIFTVAERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YW8</accession>
    <name>Q63YW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative type-b cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009969913.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106697.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0072"/>
    <dbReference type="EnsemblBacteria" id="CAH34055">
        <property type="protein sequence ID" value="CAH34055"/>
        <property type="gene ID" value="BPSL0072"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0072"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1664"/>
    <dbReference type="eggNOG" id="COG3038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLLHWVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="19006" checksum="0D34D8ADA23EA626" modified="2004-10-25" version="1">MMKTTFSPLARLLHWVMAAMIVSMLFVGAGMVTTVSGRHAALVAMHKPLGVAVLVLACVRVVVRLSSRPPALPADLPGWQKFAAYGSHLVLYALMIAMPLVGWAMLSAGGYPVTLGGGVRLPSIVPADAVWFAWLRHAHRWLAYLFFATFLAHFAAALYHGMIRRDGVLRAMVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>H7C746</accession>
    <name>H7C746_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliS</name>
        <name evidence="7" type="ordered locus">BPSL0232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203429.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106860.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0232"/>
    <dbReference type="EnsemblBacteria" id="CAH34220">
        <property type="protein sequence ID" value="CAH34220"/>
        <property type="gene ID" value="BPSL0232"/>
    </dbReference>
    <dbReference type="GeneID" id="56594419"/>
    <dbReference type="KEGG" id="bps:BPSL0232"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1480"/>
    <dbReference type="eggNOG" id="COG1516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFRDTWK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="15324" checksum="3E85F9472F87DBCC" modified="2012-04-18" version="1">MFTPGHAGASAYARVGVETGVMGASPHRLIAMLYQGARQAIAHARLHLQQGNVAARGEAIGKAIRIVESGLQQALNLEVGGDIASRLDSLYTYMCRRLLQANVDASEPMLIEVDGLLATLEDAWTGIAPEVARMNAQAVTEQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H7C781</accession>
    <name>H7C781_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">manC</name>
        <name evidence="11" type="ordered locus">BPSL2810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mannose-6-phosphate isomerase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522157.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109405.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2810"/>
    <dbReference type="EnsemblBacteria" id="CAH36820">
        <property type="protein sequence ID" value="CAH36820"/>
        <property type="gene ID" value="BPSL2810"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2810"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2497"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELKKHDP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006375">
        <property type="entry name" value="Man1P_GuaTrfase/Man6P_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01479">
        <property type="entry name" value="GMP_PMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="10">
        <location>
            <begin position="318"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="475" mass="52224" checksum="E640B1882DC6078A" modified="2012-04-18" version="1">MNIHPVILCGGSGSRLWPMSRGGYPKQYLKLAGDRSLVQQTALRLRNIPDTTAPIVVTNNEQRFLVAEQLRQVDITPSSIVLEPVGRNTAPAIAIAALLAMHDSPEALLLVLPSDHVILNEPAFITAAREAAAIAADKHLVTFGITPTQAHTGFGYIRRGPLLADGGQAFKVDAFVEKPDASTAERFVRDSGYYWNSGMFMLKAATYMEELHRHAPEIARQAEFALASAKRDHDFLRLDADAFFACPNVSIDYAVMERTERAAVIATADLGWSDIGSWSALADIADTDAQGNALVGDVFTDSVKNSYIRAEHRMIAALGLDDIVIVETADAVLVAHRDKAQDVRKIVEWLNASGRHESVTHRRVVRPWGSYEGIDQGERFQVKRIVVNPGAQLSLQMHHHRAEHWIVVKGTALVTNDGKEIILTENQSTYIPLGATHRLTNPGKIPLELIEVQSGSYLGEDDIVRFEDTYGRTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ0</accession>
    <name>Q63HZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fusion protein, pyridine nucleotide-disulphide oxidoreductase and patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205761.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112282.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2279"/>
    <dbReference type="EnsemblBacteria" id="CAH39765">
        <property type="protein sequence ID" value="CAH39765"/>
        <property type="gene ID" value="BPSS2279"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2279"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5893"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYDEVSY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021095">
        <property type="entry name" value="DUF3734"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12536">
        <property type="entry name" value="DUF3734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="413"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="417"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="599"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="757" mass="82075" checksum="74A724777EEC544F" modified="2004-10-25" version="1">MREFDYLLVGGGIASVTAARTLRGEDASASIAILCGEPVLPYQRPPLSQEWLMGAVQPASITLHDAAFYVAQRIDIALGVRAEQLDRAKRIVRTSSGATFRYGKLLIATGASAKAPALPGFGLDGVHVLHTFAQAQALKDAAAHARRATVLGGGFLGVEIAATLQALGLQVTLVERAPGVMPSLRAPALGGHFEALCRARGIDVLTRCEVRRVLGAQCVEAVETSDGGTRPCDLFVAAVGVTPNCGWLDGSGLALGDGVEVDAFLQTADPDVFAAGDVAHFDDPIFGVRRRIEHWDNAVRQGRIAARNMLGHRLPYRDVSIFYGSVFGLSYNLLGYPVGATETIERGAFDEASYMQLYLADDVLRAAFTIDRPAVEIAALNDAIRLHVNVAAHKTKLSDPNYPLDKLPVQTILILQGGGALGAFECGAVKALEQHGVRPDVISAVSIGAFNGAIVASHPKGATKALEAFWRELSIALPLPYESQWREAWLSSYVLSFGVPNFLKPQWSQLGFDADRLRAKWTSFFDATAIEQLIARYVDFDSLGMSPTRLLIGAVDVETGEPRIFDSYVDRLSPAHVLASGSLPPGMPWTVVDGRPYWDGGVVSNSPLDLVIARCGQIGGRVFIVDLFSGSKALPTNLVEVMLRREEIAYMDRVRNDLRFEEYASDFRDLVDGILAHVDAPSANEIRQQPLYIRLMGNRAAIDIARITLNREGRLSFIEDYDFSSDAIAQLQQQGYDAALVALANGRSRRRRGRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ3</accession>
    <name>Q63HZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004205322.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112279.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63HZ3"/>
    <dbReference type="STRING" id="272560.BPSS2276"/>
    <dbReference type="EnsemblBacteria" id="CAH39762">
        <property type="protein sequence ID" value="CAH39762"/>
        <property type="gene ID" value="BPSS2276"/>
    </dbReference>
    <dbReference type="GeneID" id="56598386"/>
    <dbReference type="KEGG" id="bps:BPSS2276"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5890"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFWHRDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08417">
        <property type="entry name" value="PBP2_Nitroaromatics_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037402">
        <property type="entry name" value="YidZ_PBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="34606" checksum="7FA83DF249765A07" modified="2004-10-25" version="1">MIQNLRQLDLNLLLVFDALMQEQNLSRAAIRLHMSQPAVSNALTRLRQQLGEPLFTRTARGMTPTAQARTLYEPVRQALYLLQIGLGPQADFEPDTHHLFKLSMNDYGQTVLLPDLLAHIKSRAPNVMLSVQSDDAGSIPAQLTTGTLDLAIDYLHFDNPELCYEPLHEEHLVVIGRAGHPAFAGGLALRGYEESGHVSIQPRDRRGSPLEIVLGSARVRRVVHLQVPHYLTIPALVAKSDLLGTIPRRLAERFADVYALQIAPLPIDIAPIQVSLIWHRQQDAQPGLRWLREQVVLTHRAIIGCGEHAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I48</accession>
    <name>Q63I48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112224.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39707">
        <property type="protein sequence ID" value="CAH39707"/>
        <property type="gene ID" value="BPSS2222"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2222"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6647"/>
    <dbReference type="eggNOG" id="ENOG503492S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAATDNT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021551">
        <property type="entry name" value="DUF3005"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11448">
        <property type="entry name" value="DUF3005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="225" mass="24269" checksum="85E15EE8C96415E4" modified="2004-10-25" version="1">MVAAIRVSPPAAGIFPAYPMNPAAPSRAAFAFHIVRKEVRMQNAESNPTPQKQREIAAKSPVKTPAAGRDMPDAATQEQETRAHERKLTAEAIAGKTPTGLPPIDVDQYASGDGDPVRRAASRIVTLDNANMAATDNTVDVDGKGLEARTGASEWHDNVIYSNASLDEAVDTPDDSLAGIESRPHGYRPEVEPSEGWRVVYLGTVDIEHTLGARTEHKFSFERST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I55</accession>
    <name>Q63I55_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112217.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2215"/>
    <dbReference type="EnsemblBacteria" id="CAH39700">
        <property type="protein sequence ID" value="CAH39700"/>
        <property type="gene ID" value="BPSS2215"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2215"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6639"/>
    <dbReference type="eggNOG" id="ENOG50317AF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AREWRCA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021389">
        <property type="entry name" value="DUF3022"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11226">
        <property type="entry name" value="DUF3022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="143" mass="15353" checksum="9A40065D23947690" modified="2004-10-25" version="1">MPRARRPPRAGSGRAMTLPTDLPQRLVEIEHLLSDCFASPSTTVLHVDDSSGRLTIQVSWVAARAASSLLEARCALNLVFEPNVLRRYGRLDAAARARVRERLAALARQTVDAARPVEGGEADACNATLPVTDALLDDALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I60</accession>
    <name>Q63I60_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cation transport related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523347.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112212.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2210"/>
    <dbReference type="EnsemblBacteria" id="CAH39695">
        <property type="protein sequence ID" value="CAH39695"/>
        <property type="gene ID" value="BPSS2210"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2210"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5799"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGFIAVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="338"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="439" mass="46568" checksum="2592489C1C9CFF45" modified="2004-10-25" version="1">MHETLWYLIVGGVLMLMGIVTSTLKHLPCSAAMIYLLLGYLLGPPGIGLLRIDIERDAPLLRMVTEIALLVSLFAIGLRLRVPLRDRLWAVPWRLGVVAMALTVPLLAAFGALALGLAWGPALLLAAMLAPTDPVLAHDVQVRDPNDVDLTRFALSGEGGLNDGIALPFALAGLALCGNRDVLGGASPASLAALGASAWGVAGGLAIGGLLGWCTMHTVAWLRTRHAQALGLEGFLALGLIELSYGAARLAHTFGFLAVFAAGVAMRRAEHRASGGRRPREVIGTIDSEDVVATEKHPDKARAYMAESVLGFTIELERIAEAIVMTMVGNVLADFHPAAFGWRAFAAVVALFCFARPLAVALSLAGSGATRTQRRLMGWFGIRGIGSFYYLVFALERGPIDAVRPIAPLVLAAVAASVIVHGMSATPLMNWYHRLRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I79</accession>
    <name>Q63I79_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529406.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112193.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2191"/>
    <dbReference type="EnsemblBacteria" id="CAH39676">
        <property type="protein sequence ID" value="CAH39676"/>
        <property type="gene ID" value="BPSS2191"/>
    </dbReference>
    <dbReference type="GeneID" id="56531720"/>
    <dbReference type="KEGG" id="bps:BPSS2191"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5774"/>
    <dbReference type="eggNOG" id="ENOG50339RD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQTLNPN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266291" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="10480" checksum="FFF032761A20F098" modified="2004-10-25" version="1">MNLDYFTLTRRLVLAASLAASLGGCMSSTPVWDGRFGDSVRAVMQAQIIDPHAAEHARSAPGVDGRAAAAALDNYDKSFQQTEPTPNAFVIGVGGGKTGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IB0</accession>
    <name>Q63IB0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative MmgE/PrpD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529380.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112162.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2161"/>
    <dbReference type="EnsemblBacteria" id="CAH39645">
        <property type="protein sequence ID" value="CAH39645"/>
        <property type="gene ID" value="BPSS2161"/>
    </dbReference>
    <dbReference type="GeneID" id="56531751"/>
    <dbReference type="KEGG" id="bps:BPSS2161"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5733"/>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDHCLRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266457" evidence="2">
        <location>
            <begin position="29"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD" evidence="3">
        <location>
            <begin position="42"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="4">
        <location>
            <begin position="303"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="491" mass="52401" checksum="20CF4306246B90AE" modified="2004-10-25" version="1">MNRRHFLAAAVAAGLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSATIDIVKSHLIDALGCALAALDEPPVRIARDAARSAGGGGPSTIIGTAERTSPDLATFATGTALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRELILSIALAYEIACRLMDAAAISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALADADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFVKYYPAQGFTQTAIPAALDVASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETADHSLPYVVARAMLDGDIRTTSFSDAALRDPALHALIAKIRVEEDPALTAGYPARAANRVTAHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQDVAALPPLLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC7</accession>
    <name>Q63IC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190379.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112145.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39627">
        <property type="protein sequence ID" value="CAH39627"/>
        <property type="gene ID" value="BPSS2144"/>
    </dbReference>
    <dbReference type="GeneID" id="56598173"/>
    <dbReference type="KEGG" id="bps:BPSS2144"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5713"/>
    <dbReference type="eggNOG" id="ENOG50317AY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SDIRHAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="7710" checksum="A76F55A7703D58EB" modified="2004-10-25" version="1">MKNKTTRLWRMLSDLRRAQRCTALRAAAAAADVDALLTQHDDELRDDDEATQDDASNETRLRTDLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG4</accession>
    <name>Q63IG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative FHA-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555176.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112108.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2109"/>
    <dbReference type="EnsemblBacteria" id="CAH39589">
        <property type="protein sequence ID" value="CAH39589"/>
        <property type="gene ID" value="BPSS2109"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2109"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5654"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KITPGQC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017735">
        <property type="entry name" value="T6SS_FHA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03354">
        <property type="entry name" value="VI_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="478" mass="51297" checksum="51AD78F3071EB804" modified="2004-10-25" version="1">MQLTVIEHAGEPVGTDGRNAVVFHAPGGTIGRDSDNHLVLRDDTRQISRLQALLQVADDACLLKNLSSVSTIEVNRVPIGYAQAQRLNMGDIIRIGPYLLRAEPDDATIERTVEAAATGAAAAAPAASAAQAQAKGAGNKLWGLLHERFGLGKAQGAGEQSGARAAPARHRDSPASAAPRDLNQLSTDPLDLFAQPHGDPDARAGAAREGEDRAPPTVTQPDHAPEWTQHVRVQPAQSAPPAASRPGAPAARSGDIPGADDASDMPSRVRASPAPAPATPETLLQAFFEGAGLDTAAEQHHWSAEQLFVAGQLLALFANGTVELLSSRSILKREVKADMTMLLDRENNPLKLLPDGSAVLRQMFGLPLPGFMTPQSAVSDAFQDLHAHQIGMVAGMRAALMDLLTRFSPQRLRERDAAPQWYEKRVPALYKARLWDRYAATHRDTLFAIEDDFASVFGKAFLSAYDAEVESYRGRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IL0</accession>
    <name>Q63IL0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">L-asparaginase</fullName>
            <ecNumber evidence="11">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ansA</name>
        <name evidence="11" type="ordered locus">BPSS2060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="11"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112062.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2060"/>
    <dbReference type="EnsemblBacteria" id="CAH39538">
        <property type="protein sequence ID" value="CAH39538"/>
        <property type="gene ID" value="BPSS2060"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2060"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6457"/>
    <dbReference type="eggNOG" id="COG0252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LTCAMRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="10">
        <location>
            <begin position="236"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="36785" checksum="F57A1A996C435ABB" modified="2004-10-25" version="1">MTLTIGGFTTAANAQQASAPPPQNLPRILVLATGGTIASTSDPRSAIGYNAGGITGDQLLASVPGLDKIASIKAEQISNVGSQDMNGKIWYQLAIRIKQAIDRNEVDGIVITHGTDTMEETGFFLDHVLSTSKPVVLVGSMRPGGSTSADGPMNLYEAAEVAASPQSVNRGVLMVMNDTINSPRWATKTNTTSVQTFQNPNAGPLGYVDAASIRYLSPAPTSHRKALELPSGGLPRVDIVYAHADMDATQIQDAVQHDAKGIVLAGVGDGNASKAALDAMEAAARKGIVVVRSTRVSSGFVNRNVEVPDDKSGFVASYDLNPQKSRVLAQLLIANGVTSPDKVQKAFQSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IZ8</accession>
    <name>Q63IZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188480.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111924.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1918"/>
    <dbReference type="EnsemblBacteria" id="CAH39396">
        <property type="protein sequence ID" value="CAH39396"/>
        <property type="gene ID" value="BPSS1918"/>
    </dbReference>
    <dbReference type="GeneID" id="56596890"/>
    <dbReference type="KEGG" id="bps:BPSS1918"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5398"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIPWLGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="328" mass="34367" checksum="160DE85A16B5D6F2" modified="2004-10-25" version="1">MRAMVFDGGAPRLREAELPDPVPAAGQLLIDVHACGVCRTDLHVVDGDLRDPKRPVIPGHEIVGTVAALGALAKGFTIGERVGVPWLGRTCGHCAYCASGRENLCDAPGFTGYTIDGGYAQRTVADARFCVHVPSRYDDIHAAPLLCAGLIGYRTLKMAGSARRIGLYGFGAAAHLVAQVARFQGRTVYAFTRPGDAAAQRLARRLGAAWAGGSDEAAPEPLDAALIFASVGALVPAALAAVVKGGAVVCGGIHMSDIPSFSYDLLWGERRIVSVANLTRDDAAEFMRIANDVPLDVEATPYPLAQANQALDDLRAGRLAGAAVLTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J67</accession>
    <name>Q63J67_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195649.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111855.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1851"/>
    <dbReference type="EnsemblBacteria" id="CAH39327">
        <property type="protein sequence ID" value="CAH39327"/>
        <property type="gene ID" value="BPSS1851"/>
    </dbReference>
    <dbReference type="GeneID" id="56598256"/>
    <dbReference type="KEGG" id="bps:BPSS1851"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5302"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYVIVTM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="401" mass="40826" checksum="A804B419AF58FDAE" modified="2004-10-25" version="1">MHPLRSILPLALFTAVGLLATDLYLPAVPSLPQQLGGSIESAQATLAAFSAALAVSQLVWGAAADRFGHRRTLAFAVLLQLVAGAACALAPSMGALIGARLAQGFGVGAAMVIVPALVRQSFGDGGAVRALAWLGIVESAVPGLAPLVGAALLVVADWRTSFWIIVALSAIAAPLVFRVIPTARAMRACAPANVGAHAGGYRRLLRSPVYLGYALGHALCFAALLAFVASAPQVVEIWLGAGPSTFSLMQACGVAAFMLSAARSGKWSDALGLDRIIALGALLQFAASAAFLLLAYADWRSTPLVVASWMLFCGSLGLRGPASMARALAAEPAVAGRAAGLLMFFGLGGAALATQAVAPFLRLGLAPVAWMCAGFTLASGAVVLWGIAIRGRHRAAATEIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JD9</accession>
    <name>KHSE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homoserine kinase</fullName>
            <shortName evidence="1">HK</shortName>
            <shortName evidence="1">HSK</shortName>
            <ecNumber evidence="1">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrB</name>
        <name type="ordered locus">BPSS1779</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudomonas-type ThrB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530313.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111783.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JD9"/>
    <dbReference type="SMR" id="Q63JD9"/>
    <dbReference type="STRING" id="272560.BPSS1779"/>
    <dbReference type="EnsemblBacteria" id="CAH39255">
        <property type="protein sequence ID" value="CAH39255"/>
        <property type="gene ID" value="BPSS1779"/>
    </dbReference>
    <dbReference type="GeneID" id="56529805"/>
    <dbReference type="KEGG" id="bps:BPSS1779"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5218"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPTHFER"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05153">
        <property type="entry name" value="HomoserineK_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00301">
        <property type="entry name" value="Homoser_kinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005280">
        <property type="entry name" value="Homoserine_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00938">
        <property type="entry name" value="thrB_alt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0791">Threonine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000172188" description="Homoserine kinase">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00301"/>
        </source>
    </evidence>
    <sequence length="331" mass="36760" checksum="58716C289DEA937C" modified="2004-10-25" version="1">MAVFTAVSDADLALWMRHYDLGDVVAFRGIPSGIENSNFFLTTTRGEYVLTIFENLTAGQLPFYVDLMSHLAKHGVPVPAPVARDDGTLFGELHGKPAAIVTKLEGAAQLAPGVEHCVEVGQMLARMHLAGRDYPRHQPNLRSLPWWRDTVPAIAPFVTGEQRALLEGELAHQAAFFASDDYAALPEGPCHCDLFRDNALFAHAEPDTGHSVRLGGFFDFYFAGCDKWLFDVAVTVNDWCVDLPTGALDAARADALLRAYQTVRPFTAGERRHWGDMLRAGAYRFWVSRLYDFHLPRAAQMLKPHDPGHFERILRERIAHAGALPETHACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH5</accession>
    <name>Q63JH5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lipA1</name>
        <name evidence="3" type="ordered locus">BPSS1741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553588.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111747.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63JH5"/>
    <dbReference type="STRING" id="272560.BPSS1741"/>
    <dbReference type="ESTHER" id="burps-q63jh5">
        <property type="family name" value="Bacterial_lip_FamI.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39216">
        <property type="protein sequence ID" value="CAH39216"/>
        <property type="gene ID" value="BPSS1741"/>
    </dbReference>
    <dbReference type="GeneID" id="56529846"/>
    <dbReference type="KEGG" id="bps:BPSS1741"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5167"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYFSWSG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266506" evidence="1">
        <location>
            <begin position="24"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="364" mass="37404" checksum="9A287BCE68F72A06" modified="2004-10-25" version="1">MARTMRSRAVAAAVAFAVSAAPAAGIGTFLSLAGTQAAAAATSAVDNYAATQYPIILVHGLTGTDKYANVLEYWYGIREDLQAHGAQVYVANLSGFQSDDGPNGRGEQLLAYVQQVLAATGASKVNLIGHSQGGLTSRYVAAVAPQLVASVTTIGTPHRGSEFADFVQTVLAYDPTGLSSTVIAAFVNVFGILTSSTNNTNQDALAALKTLTTSQAATYNQNYPSAGLGAPGSCQTGAQTETVGGNTHLLYSWGGTAIQPTLSILGVTGATDTSTIPVVDPANVLDASTLAMLGSGTVMINRGSGANDGLVSRCSSLYGQVLGTSYKWNHLDEINQLLGVRGAYAEDPVAVIRTHANRLKTQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP3</accession>
    <name>Q63JP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111679.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1674"/>
    <dbReference type="EnsemblBacteria" id="CAH39147">
        <property type="protein sequence ID" value="CAH39147"/>
        <property type="gene ID" value="BPSS1674"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1674"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5077"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWNLASE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266513" evidence="2">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="69"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="317" mass="34097" checksum="2D67A8859F8ADBF8" modified="2004-10-25" version="1">MKLPYTKSKSFAASLARAVVAFALAGIGAAAFAATFDLSPEQPGRVRGARDDAVIRALPASFKFVEPDTLTVGIAPSQPPISAYATDARTVVGFDADLAQLLADSLGRKLKIVALAWPDWPLALESGRVDAVLSNVTVTEERKAKFDFSTYRKDQVGFYVKSDSKIASIRQPRDVAGLRVITDAGTNQEKILLEWDRENVAHGLKPVTVQYYDDHAVKSVALQAGRADAIFSVNSVLAYQAAQQHRTKLVGAVSGGWPRTADIAVTTRRGSGLAAPFTLAINGFIRNGTYRRVLERWSLGSEAIDASRTNPPGLPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K22</accession>
    <name>Q63K22_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bsaP</name>
        <name evidence="3" type="ordered locus">BPSS1544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555023.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111550.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K22"/>
    <dbReference type="STRING" id="272560.BPSS1544"/>
    <dbReference type="EnsemblBacteria" id="CAH39017">
        <property type="protein sequence ID" value="CAH39017"/>
        <property type="gene ID" value="BPSS1544"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1544"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4899"/>
    <dbReference type="eggNOG" id="ENOG502ZABZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YASMSML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010812">
        <property type="entry name" value="HrpJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003520">
        <property type="entry name" value="Invas_InvE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013401">
        <property type="entry name" value="T3SS_LcrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013351">
        <property type="entry name" value="T3SS_TyeA-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07201">
        <property type="entry name" value="HrpJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01344">
        <property type="entry name" value="INVEPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02568">
        <property type="entry name" value="LcrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02511">
        <property type="entry name" value="type_III_tyeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HrpJ" evidence="2">
        <location>
            <begin position="54"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="368" mass="39901" checksum="3E230D838DA8448A" modified="2004-10-25" version="1">MSSIIGGASAARRGFSIDGTGSAANRLDAEPSLDDAPQTGAAGAADVQAQLAGVDEEAANAAAQFGRFRASERKGRRSDELERILDTDADEKLDELAALLGGRADLATLLRDARERFRDESDLLLALRELRRRRRLDGESVDALERAIDELLAGDGAKRIKAGINAALKAKVFGARMQLDARRLRELYRQFLEFDGSHLVIYEDWIEQFGASRRKRILDYVSAALSYDMQSHDPSCGCAAEFGPLLGTLHRARMLASADEQFVGRLLDDALARDCGLTEARALATMLGGLQRPFSVADVLLGTLGDLLEPLAPARRSQLLQLALRAFAGVPIALYGDADARRAALGALEELIGATYARERRQARPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K89</accession>
    <name>Q63K89_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mannitol dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205623.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111483.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1476"/>
    <dbReference type="EnsemblBacteria" id="CAH38948">
        <property type="protein sequence ID" value="CAH38948"/>
        <property type="gene ID" value="BPSS1476"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1476"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5724"/>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKPYDNL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="3">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="4">
        <location>
            <begin position="217"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="489" mass="53055" checksum="90B1647557EA02D7" modified="2004-10-25" version="1">MPLLSSDHCRALPPEVSRPRYDRRALRTGIVHLGLGAFHRAHQACYTETLVERGDLRWGIAGVELRRRHTVERLAAQDHLYSVTERAGDAARTRVVGAVHRTLFAPQALATLLGLIADPAVSIVSLTVTEKGYYRRPGGGGLDLDDPAIRRDLAQPHAPSTTLGVLAAGIRLRAAHAPLSVLSCDNMPSNGDTLRALLAQYAEQTDGALARRIRCDVAFPNTMVDRIVPAATPESLDWVQSRIGVRDEAAIVCEPFAQWVFEDRFAGARPRWEDAGALVAADVRPYEKMKLRLLNGSHSAIAYAGQLRGRRTVSDAMADPLIDALARGVMTRELLATLDVPAGYDVRAYCASLIERFRNPALAHRTAQIATDGTQKVPLRWLPALAESAAAGVERPFLERSLAMWLHYVEVARDESGRPLVLEDPGAQALAARLHGAPGATDAVRAALGLIASRDAARWPEALTARVGAHLETVRTRGTDALLRPLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K96</accession>
    <name>Q63K96_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BPSS1469a</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533132.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111476.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1469a"/>
    <dbReference type="EnsemblBacteria" id="CAH38941">
        <property type="protein sequence ID" value="CAH38941"/>
        <property type="gene ID" value="BPSS1469a"/>
    </dbReference>
    <dbReference type="GeneID" id="56530116"/>
    <dbReference type="KEGG" id="bps:BPSS1469a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4805"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="16427" checksum="84D0B52CB7392728" modified="2004-10-25" version="1">MTIRIDDIVPLSIARARFSELADDARDGGEKIITKNGAAYVALIDARRLDHYHRLERERAECACAALLHGGGGDGRDSDDRGNGGDAACDAARSGRRDSPDGRGAAIAAGRETGAANATDATGAPGTMGAMAAPCDSDGADALAPDALAPDAPSAERRAGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K99</accession>
    <name>Q63K99_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525371.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111473.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1467"/>
    <dbReference type="EnsemblBacteria" id="CAH38938">
        <property type="protein sequence ID" value="CAH38938"/>
        <property type="gene ID" value="BPSS1467"/>
    </dbReference>
    <dbReference type="GeneID" id="56530119"/>
    <dbReference type="KEGG" id="bps:BPSS1467"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4801"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRKIYKH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="408" mass="43168" checksum="C7B6764541CFF088" modified="2004-10-25" version="1">MTLAAAVDYPFAAPFADPQGSPIRELFKHVGKPGMISFAGGYPSAELFDREGIAAAFADAARDDPVACLQYGDTAGQPGLRAALADWMTRARGVACDASQVLVTTGSQQGFDLLVRALIEPGDVALVEAPAYPAALQALRLAGAKLVPVRTDADGVDPDALAAQLAAWPAAERRPKLLYTVPTFANPTGATLPPARRARLAAVAADARLVLVEDDPYADLRFAGEPVKPVLAHDGASDWTVYLGSLSKIVAPGLRIGWAVAPAAVLRRMTVAKQTSDLCTAPIAQEAIRRYLASGRLAAHLRTIAQTYGSRCRALVSALAQFVPDDVEWREPSGGMFVWARLGGGRDASEVLKRALEHNVMYVPGAAFYARDADAGSLRLSFAAPGEAEIFEGVRRLRAALAACRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KB6</accession>
    <name>Q63KB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative acyl-coA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525387.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111456.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1448"/>
    <dbReference type="EnsemblBacteria" id="CAH38919">
        <property type="protein sequence ID" value="CAH38919"/>
        <property type="gene ID" value="BPSS1448"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1448"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4778"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901565">
        <property type="term" value="P:organonitrogen compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="10">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="9">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="8">
        <location>
            <begin position="235"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="374"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="347"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="376"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="393" mass="42683" checksum="ECA46978F1DBAF49" modified="2004-10-25" version="1">MSNLPGVNFMLGEDIEMLRDSIAHFAAKEIAPRAAEIDRTDQFPMDLWRKFGELGVLGMTVAEEYGGANLGYTAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTDAQKRRYLPKLISGEHIGALAMSEPNAGSDVVGMKLRAEPRGARYVLNGTKMWITNGPDCDTLVVYAKTEPEAGARGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPEENILGELNGGVKVLMSGLDYERAVLAGGPTGIMAACLDAVVPYVHDRKQFGQPIGEFQLIQGKIADMYTTFQACRAYLYAVGRHLDAGGSAHPRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYPVGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE3</accession>
    <name>Q63KE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.17" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194988.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111429.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1417"/>
    <dbReference type="EnsemblBacteria" id="CAH38892">
        <property type="protein sequence ID" value="CAH38892"/>
        <property type="gene ID" value="BPSS1417"/>
    </dbReference>
    <dbReference type="GeneID" id="56530163"/>
    <dbReference type="KEGG" id="bps:BPSS1417"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4741"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="10"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="213" mass="22733" checksum="390DB248EF175DD2" modified="2004-10-25" version="1">MSPIETKLREEICEIGASLYARGHAVGSAGNISAKLDDGWLITPTDACLGRLDPAGIAKVDPAGNAVSGGKPSKTLALHRGIYARNAEARGIVHTHSTHLVALTLAGVWSEADVLPPITPYYVMKVGHIPLIRYRRPGDPAVAAEVAALADRVRGVLLERLGPVVWGPSVAHASYALEELEETARLWLITHPKPEPLGEPALAELRDAFGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KH2</accession>
    <name>Q63KH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551817.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111400.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1388"/>
    <dbReference type="EnsemblBacteria" id="CAH38863">
        <property type="protein sequence ID" value="CAH38863"/>
        <property type="gene ID" value="BPSS1388"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1388"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4709"/>
    <dbReference type="eggNOG" id="ENOG502ZB52">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FTHAENY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031613">
        <property type="entry name" value="HrpK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16937">
        <property type="entry name" value="T3SS_HrpK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="602" mass="61355" checksum="EAB8CAA590C859F1" modified="2004-10-25" version="1">MAISPTIATNRQVVGSVGSENVPGPAAEALQSVESQLHQLMARQLQGGVAMAQRQGSGIRAAQYAPLDDYTRMYDQADRDRWADLAALGQGVSLERPLAAMQILSGERQPSAAQTAAALQFVNDNPSLKTAMQNTGGLKPDGSVDPGKVADLLKEVEANLAKADEDVKAYLNDHPDADRDALDTVRAAALLEAYEPIVGQSAGHQSSGKNHSYSTGGKNNGGGLTTKQQVADLQNNGGFSAALKSAAKAWSTSGAFDNLDRAGDDKATEKVDQIFSANNLHHFITKDAPTSDAAEHAFLEKASLENITAGTDISKLNQDIFANPQDYSPQQKAAVMVKLMETLVDVQAGGADKLRDVTATVSALKQDIMMLANDPETNAYLHQMVPPEMRDLNATFEQAGGLEGDTGAAGDMSVADNANRVSARNIVDQTKDALDEAEKVAKRLGKLGNEGAGEATDATQSIADGAETAADGAVQGGVEEVGGAAASAVDGAEGAITGVADGVEAADGAVTGVAEGVEGALAGTEGAVVGAEAGAGVAEGVMGAVAGGMAAAAPVLAVGAAIAGIAGIVLAIVEAVKKAQNRKAFAENVNPTLNQFGIPLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ1</accession>
    <name>Q63KQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estA</name>
        <name evidence="2" type="ordered locus">BPSS1311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111320.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1311"/>
    <dbReference type="EnsemblBacteria" id="CAH38781">
        <property type="protein sequence ID" value="CAH38781"/>
        <property type="gene ID" value="BPSS1311"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1311"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5522"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GTFFWID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="404" mass="42263" checksum="F51DF95E5FA652DF" modified="2004-10-25" version="1">MRIHTMNSAFDAPASAAAAAFPPADDAALAARLDRVLGAALGERRIVGAVALAARHGRLVYRRAHGLAERETQRPMREDTLFRLSSITKPIVTVAVLRLVADGRMALDAPITRWLPDFAPALPGGRAPALSVHQLLTHTAGLSYWLLEAPGSAYHTLGVSDGIDLVDFDLAENLRRIAAAPLAFEPGSAWRYSLALDVLGAAIERETGRALPDAVARLVTTPLGMRDTGFVAADPARFAVAYANAAPEPARITDNLDVPLPEGHGVAVRFAPSRVFDATAFASGGAGMYGSADDVLRVLETIRTGGDGFLPAALVAAMRTDHTGPAAGTRGPGWGFGYGGAVLSDPALAQSPQSAGTLQWGGVYGHSWFVDAARGLTVLLMTNTAYEGMSGPLTLEVRDAVYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KW9</accession>
    <name>Q63KW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524182.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111252.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1244"/>
    <dbReference type="EnsemblBacteria" id="CAH38711">
        <property type="protein sequence ID" value="CAH38711"/>
        <property type="gene ID" value="BPSS1244"/>
    </dbReference>
    <dbReference type="GeneID" id="56530338"/>
    <dbReference type="KEGG" id="bps:BPSS1244"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4498"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IPCFMFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="441" mass="46188" checksum="82CAC79E53688AB1" modified="2004-10-25" version="1">MSDKATRIELLDWRTVPMRAFHLTWIAFFVCFFAWFACAPLMPLIAREFRLSADQVANVNIAAVAATIAVRLVVGPLCDRFGPRRVYAGLLACGAIPVFAVTLSHDYLTFLLCRLGIGAIGASFVITQYHTSVMFAPNVVGTANAAAAGWGNAGAGAAQAAMPLVVAAALLLGLPDACAWRAALAVPGAAMLVMAIVYWRGTQDCPQGDFVALRARGVTIDSGKKGGFASFAAACGNYRVWMLFVTYGACFGVEVFMHNIAALYYVNHFALSLKDAGLAAGIFGLLALFARALGGWLSDRVAARRGLDVRATLLFALILGEGLGLLWFAHAGSVPVALVAMVAFGLFTHMACGATYALVPFIDRRALGGVAGIIGAGGNAGAVAAGFLMKGVGDIQQTLTLLGLFVTVSAFCALAVRFSAEHKAREAALRERALAASGFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KX2</accession>
    <name>Q63KX2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Putative bifunctional reductase</fullName>
            <ecNumber evidence="23">1.7.99.4</ecNumber>
            <ecNumber evidence="23">1.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ordered locus">BPSS1241</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="23"/>
    <dbReference type="EC" id="1.8.1.2" evidence="23"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205569.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111249.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1241"/>
    <dbReference type="EnsemblBacteria" id="CAH38708">
        <property type="protein sequence ID" value="CAH38708"/>
        <property type="gene ID" value="BPSS1241"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1241"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4495"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGWEAMP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="22">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="884"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="1050"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAH38708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1418" mass="151970" checksum="B850F8F6714B5076" modified="2004-10-25" version="1">MTSASVKTVCPYCGVGCGMVLHVEDGEVVKVSGDAEHPTNLGRLCTKGSSAHVALRNAGRLERAFVRDARELDPAPVPIADAIAETARRLRATLDAHGPDALAFYVSGQMSLEAQYLVNKLAKGYVRTPHIESNSRLCMASAGSGYKLSLGADGPPGSYQDFERADLFFVIGSNMADCHPILFLRMMERVKAGAKLVVVDPRRTATAQKADLFLKIRPGTDLALLNGLLHLLHANGRTDADFIAAHTEGWDAMPGFLADYTPQRVAALTGLAEADIRLAAQWIGDAREWTSCWTMGLNQSTHGTWNTNAICNLHLATGKICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSALDGDDRRFVEEIWGLPAGTIRPDAGGGTVDLFARMAAGDVKACWIICTNPVATVANRKNVIAGLQAADVVIVQDAFLDTETNRYADILLPGALWAEAEGVMINSERNLTLMRQALEPPGDAWPDWRIVAAVARGMGYGDAFDYGSAAEVFDEIRRFANPNTGYDLRGASHAALRATPLQWPCPPEDGRDRHPIRYLNDGASRPRVTLPDGCVPPLAFPTPSGKARFFARPHVAPAEMPTPEFPIVLNTGRLQHQWHTMTKTGKVAMLNKLDARPFVEIHPDDAAALSIAANDAVEIRSARGRAVLPAVVTDRVQPGACFAPMHWNDVYGDDLCVNAVTNDAVDPVSLQPELKFCAVALARVDAPDSADAGAHAGAHAAPLHETGSREAQAQAAPRAHEAACADAAPEEHDMSDIDTFAALLGVPAATSAPQLTDAQRVYVSGFVSGLRSAEGRRAGGVPMLPASAPFDAKARLWLDGLLAGLFSRAPLGAAARVDARAAAAAAVPAPSGAADAVSAPSGVRIVRTRPKVVLLWASQTGNVESLTERYATQLMDSGFEIRVACMSDYPAASLAKAQYALLMTSTFGDGDAPDNGQAFWTALAAAGAPRADGLRYAVLAFGDRNYDPFCGHGRRLDARLAELGATRLVERVDCDAEFQPAADAWLERAIARIKEEDAALHAVPADGMIPSGAIPTKTRPAASRLVANLRLNEPGAAKDTRCVSLSTDGAAIEYETGDALGVWPTNCPELVDELLALTRLKPDAPVTVAGMGELRLADALAKHLDITRPHPDALAFVASRSRAGDALARLLGDDRKTDLKHWLWGQQLADVLHEFPLELSAAELVGMLKRLQPRLYSIASSPSAHRGEIHLTVSAVRYGNGRRQRKGVASTFLADRAADAPVPVFVQKSAHFRPPASGDAPIVMVGPGTGIAPFRGFLHERRARGAKGRNWLFFGEQHADTDFYYRDELAQMRADGFLTRLDVAFSRDQTEKVYVQDRMLEQGAALWAWLEEGAHFYVCGDASRMAKDVDAALKTIVARHGGMTDEQAADYVARLAKDKRYARDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L75</accession>
    <name>Q63L75_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2,4-dienoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fadH</name>
        <name evidence="4" type="ordered locus">BPSS1133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.34" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552478.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111146.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1133"/>
    <dbReference type="EnsemblBacteria" id="CAH38601">
        <property type="protein sequence ID" value="CAH38601"/>
        <property type="gene ID" value="BPSS1133"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1133"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4352"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFLAAHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="7"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="376"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="673" mass="72759" checksum="549262F02C41AF6A" modified="2004-10-25" version="1">MTFYPHLTAPLELGFTSLKNRVLMGSMHVGLEEAANGFERMAAFYAERARGEAGLIVTGGIAPNERGRMMPGGSMLTTEEEAERHRIVTRAVHDAGGRIAMQILHFGRYAYHPALVAPSALKAPINTFTPHALSASEVDATIDDFARCAALAQYAGYDGVEIMGSEGYLINEFIAAHTNHREDEWGGAYENRIRFPVEIVRRVRERVGTNFIIIYRLSMLDLVEGGSTLDEVIRLAQAIEAAGATILNTGIGWHEARIPTIATKVPRAAYAWVTKRLVGRVGIPLVATNRINTPEIAEQLLAEGYCDMVSMARPFLADAQFVRKAREGRADEINTCIGCNQACLDHIFSGRITSCLVNPRACHETELVIEPAERRKRIAVVGAGPAGLSFAVTAAERGHDVELFEASPEIGGQFNIAKKVPGKEEFHETLRYFRRQLELRGVTLHLNTRADVARLAGGGFDEIVLATGVTPRRPDIEGIGHARVMGYLDVLRDGKPVGASVAVIGAGGIGFDVSEYLTHTGESASVAPSTFYAQWGIDIDYGARGGVRMPHVEAAPRNVHLLQRKASKVGDGLGKTTGWIHRTSLKARRVAMSSGVSYERIDDAGLHVRIDGEPRTLAVDSVVVCAGQEPQRELYDGLRAAGCSVHLIGGAHVAAELDAKRAILQGTTLAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L92</accession>
    <name>Q63L92_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539143.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111129.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1116"/>
    <dbReference type="EnsemblBacteria" id="CAH38584">
        <property type="protein sequence ID" value="CAH38584"/>
        <property type="gene ID" value="BPSS1116"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1116"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4331"/>
    <dbReference type="eggNOG" id="COG3653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GCPEVID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="584" mass="64526" checksum="E1933604EC371D68" modified="2004-10-25" version="1">MTRYDTIIRNGLWFDGTLAEPRPRELGIRDGRVAAVSDTPLAADGASVIDATGKWVMPGFIDIHTHYDAEILVSPGLPESVRHGVTSVFLGSCSLSTVHANALDCTDLFSRVEALPREQMLAVLSRVKTWDTAAAYVRHLESLPLGPNVAAFLGHSDLRTHVLGLGRAVDDRVRPHEAELQRMERLLDDALDAGFVGLSSMTTPWDKLDGERYRSKSLPSTFATWREYRRLNRVLRRRGRVLQSAPNTTNPLNGLLFMAESCGYFVRKPLRTSLLVAADSKAAPRGTIDVQLGGVRVANALFRGELVWQHLPVPFEVYADGIDFVIFEEFGAGRAALHLADALERNKLLQNEGYRREFRRQVGKGFDLRLWTRDLHDTRIVGCPDASVVGKSFGQVANERGVHPADAFLDLVVAHGQRLRWCMTIANHRADVLDRIATHPALQIGFADSGAHLRNMAFYNAPVRFLRRVREAERAGRPFMSVQQAVHRLTGELGAYFGVDAGTLRAGDRADIAIVDPAHLDASVDAYHEEDMAVFGGLRRLVNRSGAAIAATLVNGQLVYRDGAFVEGFGDTRRSGRFLRAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LF4</accession>
    <name>Q63LF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111067.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1056"/>
    <dbReference type="EnsemblBacteria" id="CAH38522">
        <property type="protein sequence ID" value="CAH38522"/>
        <property type="gene ID" value="BPSS1056"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1056"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="51" mass="5796" checksum="9456378DFF1A41D5" modified="2004-10-25" version="1">MPRRPRKKKISMDIDAELLERVDRAAHAMGISRNAVLALGASRFVDETMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LK5</accession>
    <name>Q63LK5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative halogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111016.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1010"/>
    <dbReference type="EnsemblBacteria" id="CAH38471">
        <property type="protein sequence ID" value="CAH38471"/>
        <property type="gene ID" value="BPSS1010"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1010"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5137"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYSASEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="30"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="573" mass="64327" checksum="0EE966F3DF92D62B" modified="2004-10-25" version="1">MPAGFPDGFIDEDSTTGWRNTMSNNQVRKYDVVIIGTGIGGTTLGAILARHGLRVAMIDSGTHPRFAVGESTIATTTLTLELMAMRFDVPELKHITSIAEVSENVMPSCGVKRNFGFVYHREHTEQNPQEVNQALVVNEVHYFRQDIDAYMLHVAIRYGCDAYQNTVVDDIRIDAGGVTVTTRGGLTFEADFVADGAGYRSVLADKLGLRETPCRAKTHARGLFTHMIDVKPFDACREVPKALQQPVPWHQGTLHHLFDGGWMWVIPFNNTPESKNPLVSVGLMLDPRKHPKPDVRPEQEFADFIAKHPDMARQFADARAVREWVSSGRIQYSASECTGDRFCLLSHATGFIDPLFSRGLFNTMQTTNALAGLLIEAAKDRDFSKARFAPVEKLQQGLIDFNDRLVNCSYLSWGHYPLWNAWFRLWLLTGNYGQLHLQRVMMKYRQTGDARWLEPADALLPGAFTTLEPIMRLFEEAAVCVERYGAGELSGEAAERAIYALLEENAALLPPFFDFVSPAERITWPSTPEKIAALLLEWVERLPEDVRAEYFDYDVRALLQQPVVKDTITADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LL3</accession>
    <name>Q63LL3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydroxymethylglutaryl-coenzyme A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524093.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111008.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1002"/>
    <dbReference type="EnsemblBacteria" id="CAH38463">
        <property type="protein sequence ID" value="CAH38463"/>
        <property type="gene ID" value="BPSS1002"/>
    </dbReference>
    <dbReference type="GeneID" id="56530543"/>
    <dbReference type="KEGG" id="bps:BPSS1002"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7326"/>
    <dbReference type="eggNOG" id="COG3425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="274"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="419" mass="46589" checksum="1D77BAA6C204FA73" modified="2004-10-25" version="1">MTAVGIEALNVYAGVASLDVSRLAEHRKLDMARFQNLLMREKSVALPYEDPITYGVNAAKPIVDALTPDERDRIEMLITCTESAFDFGKSMSTYFHHHLGLKRNCRLFEVKNACYSGVAGLQTAINFILAQVSPGAKALVIATDLSRFIVEEGGEALSADWSFAEPSSGAGAVAMLVSDTPHVFRIDVGANGYYGYEVMDTCRPTTDSEAGNSDLSLLSYLDCCENAFLEYQKRVCDVDYASTFGFLAFHTPFGGMVKGAHRNLMRKASRCSTQEIEQDFQRRAGPGLVYCQRLGNIMGATAMLSVASTIDNGEYRAPQRVGVFSYGSGCCSEFFSGIVDEEGQRRLRGMRIGEQLDRRYALSIDEYEHVLKESRVVRFGTRNAKIDDGFIPAARRAHGRETLFLSRINEYHREYEWIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LZ0</accession>
    <name>Q63LZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110881.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0872"/>
    <dbReference type="EnsemblBacteria" id="CAH38334">
        <property type="protein sequence ID" value="CAH38334"/>
        <property type="gene ID" value="BPSS0872"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0872"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4970"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYLVKRC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="237"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="38121" checksum="5DFB4B886DCB3206" modified="2004-10-25" version="1">MTPQARQAAAPPRVLAAAPHRHSLEASMLFQSRSLEDVHDHGLAIAGWRQVYRQMTPGRFRGTVTQVLYDDFHFFRETTNRRVAQTGVSPEGRTSLAVPLLAPLSGTFQRQHVDGYALLALRPGEDFEFHTPEGMRLVGISAAPDMIEELCEAEFGTRGHRAPRHVTRLTHEQGAALGARLSSYIDDAQRNPTWLAYDGTRKMFRDAMLGVFLDALSGAVGEERRDITHATYSDIVGRCERYLRARPEEPVTVLELCRALRCSRRTLQTSFQRVADVTPVTYLRTIRLNAVRRLLRTTSADALCVGEAAARWGFTHLGYFAREYRGLFGELPSQTRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M38</accession>
    <name>Q63M38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110833.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0822"/>
    <dbReference type="EnsemblBacteria" id="CAH38284">
        <property type="protein sequence ID" value="CAH38284"/>
        <property type="gene ID" value="BPSS0822"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0822"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7093"/>
    <dbReference type="eggNOG" id="ENOG5030TTN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIYWHTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="32308" checksum="1AEA598E1D6122FD" modified="2004-10-25" version="1">MDAYRSPFDDWHQAASVRSMPADAWLAGGAGAWIAPQAGGVLAGLPARDARRERAAGGLLIAHLSFTVALENTLISPVARDIAARALHADYDDGVVADALRVQCDEAYHALLAQELMTRVRAATGADKPRRTPGFLRHVERLAATLPGVDAPLLRFCAAVVAETLITHTLRDDWRDEGLQPDVRTFLRRHYLDEARHSAYFSRLLTLLWPQWPAGVRDALRPLWSGLIDAFLFADARIAAEALAAAGLTACEIDRAMSACGAPDAMQRRRAQSARQTLHALRAAGALEAGESAAIALGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MB1</accession>
    <name>Q63MB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GerE familyregulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528023.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110760.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0749"/>
    <dbReference type="EnsemblBacteria" id="CAH38209">
        <property type="protein sequence ID" value="CAH38209"/>
        <property type="gene ID" value="BPSS0749"/>
    </dbReference>
    <dbReference type="GeneID" id="56530801"/>
    <dbReference type="KEGG" id="bps:BPSS0749"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6987"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CQQHWKQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="29569" checksum="39B3A2A0768AA76A" modified="2004-10-25" version="1">MDRLFSEVAMHQAFGRALDHLGEPRFWRLLILFLNEMVPFDNALATALGRDGAPVVLDEYDTGGASGPSPVPLYLNGLYLLDPFLQAAHDGLADGCYRLEEVAPDLFRQSEYFLSYFRDAVGEDELQIIVRTRPDEMLSLSLGAHARFDTDTLGRLAACSPWLLAAIRQHRRLQGDASRARASDDLAERVERALASFGAPLLTEREMAIARLVLRGNSSKAIAERLAISPETVKVHRRHLYSKLGISSQPELFSLFLQALGHDAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MF3</accession>
    <name>Q63MF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative periplasmic solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198094.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110718.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0704"/>
    <dbReference type="EnsemblBacteria" id="CAH38164">
        <property type="protein sequence ID" value="CAH38164"/>
        <property type="gene ID" value="BPSS0704"/>
    </dbReference>
    <dbReference type="GeneID" id="56597612"/>
    <dbReference type="KEGG" id="bps:BPSS0704"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6919"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSTTDTK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266991" evidence="1">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="40027" checksum="E0C56B45274DC63E" modified="2004-10-25" version="1">MHHAPAGIAAVLFVAASTVCAQVPAGYPGNYQHVIDAAKQEGKLVVYSTTDTSLVRPLIKDFESLYGVKVEYNDMNSTELYNRYVSESAAKSASADVLWNSAMDLQVKLVNDGLTAAYDSPETPHMPQWAQYQKQAYGTTYEPLAIVYNKRLIAERDVPKTRADLIRLLQSQPERFKGKVTTYDIEKSGVGFNYLTQDAHVNEKVTWELVRAIGATGPKLQSSTGAMMERISSGENLVGYNIIGSYAYAKAKKDKSIGYVLPKDYTLVVSRLVAISKQAQHPNAAKLWVDYLLSRRGQTLIANQANLYSIRADVSGETSMTSLAKELGDSLKPIQIGSGLLVYLDQSKRLAFLKQWQQALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MN7</accession>
    <name>Q63MN7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551439.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110634.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0613"/>
    <dbReference type="EnsemblBacteria" id="CAH38070">
        <property type="protein sequence ID" value="CAH38070"/>
        <property type="gene ID" value="BPSS0613"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0613"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6796"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYANRHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="33209" checksum="4E960CFD61027321" modified="2004-10-25" version="1">MAEHPLPEVHSDELDSFRSVQQLAYRCVETVGDMLYPGITEKQAAQLMTEWARDHGVHDWLHKPFAWFGDRTAFEGFSGLKHLGGFNLAFFPSNRVLEPDMPVILDVAPVVDGIVADVGYATCLGHNPILEQLQDDLIAHRDMIVKLVKERRTLAEVAQEVDALCRRQGVEPRHKAYPFKVLAHRVAKLHKLSKPRFVARFGLNSTRNLLLEQARAGKEQGWSPLWSIDARSDHAPTPGLWAVEPHLGFAGVGAKFEELLVITDDDAYWLDDDLPHVRRWQARAASKALVHEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS0</accession>
    <name>Q63MS0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity branched-chain amino acid transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">braF</name>
        <name evidence="9" type="ordered locus">BPSS0578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530071.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110599.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0578"/>
    <dbReference type="EnsemblBacteria" id="CAH38035">
        <property type="protein sequence ID" value="CAH38035"/>
        <property type="gene ID" value="BPSS0578"/>
    </dbReference>
    <dbReference type="GeneID" id="56530971"/>
    <dbReference type="KEGG" id="bps:BPSS0578"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6751"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="257" mass="28615" checksum="DE9ED97E02CE6933" modified="2004-10-25" version="1">MSATTEMLKVSALQMRFGGLLAVDGVDFDVRRDEVFAIIGPNGAGKTTVFNCIGGFYRPTGGRVVLDGHSIGGLTSHLVARKGLVRTFQNIRLFQSLTVVENLLVAQHRQVKSGLLHGLFATPAYRRAEREALERAAMWLERMNLTAVANRPAGTLSYGHQRRVEIARCMITNPRLLMLDEPAAGLNPQEKVELQHLIDRLRREFGISVLLIEHDMSLVMGVSDRILVMEHGRPITIGRPDEVRNDPRVIKAYLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MZ3</accession>
    <name>Q63MZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196021.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110526.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0505"/>
    <dbReference type="EnsemblBacteria" id="CAH37962">
        <property type="protein sequence ID" value="CAH37962"/>
        <property type="gene ID" value="BPSS0505"/>
    </dbReference>
    <dbReference type="GeneID" id="56597047"/>
    <dbReference type="KEGG" id="bps:BPSS0505"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6663"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMSTRHF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="321" mass="34987" checksum="7A3D39FDB1EC2ADE" modified="2004-10-25" version="1">MRLIVYILVFPDLNLLDLSGPLQVLSSANELSREAGADAPYDIRVVARGGRSVRTSTGISLSTQPLAPIDAPADTVIVAGGAGVDAAARCADTLAWLRAHARQARRVVSICNGAFLLAACGLLDGRRAVTHWQCCDALARRHPRVRVEHAPIFVQDGPIWTSAGVTAGIDLCLRLVSNDCGHTLALALARYLVVFLVRPGSQAQFSESIEMQSASGQFADLHAWIRRHLRADLSVPTLAARVNMSERSFVRHYRNAFGTTPAKAVERIRVETARNLLGETALPVKQIAQRCGFGSVATLRRSFARAFDTSLHEYRERFRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N95</accession>
    <name>Q63N95_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriophage protein Gp44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537646.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110424.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0401"/>
    <dbReference type="EnsemblBacteria" id="CAH37854">
        <property type="protein sequence ID" value="CAH37854"/>
        <property type="gene ID" value="BPSS0401"/>
    </dbReference>
    <dbReference type="GeneID" id="56531153"/>
    <dbReference type="KEGG" id="bps:BPSS0401"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4392"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="49" mass="5577" checksum="98F747E0A1D2AC53" modified="2004-10-25" version="1">MLFLVLLSIVTPWLVNQDSSITLLAVPFVWLAYAAAFVKFIPPHFKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NE8</accession>
    <name>Q63NE8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative copper-related MerR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939394.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110371.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0351"/>
    <dbReference type="EnsemblBacteria" id="CAH37799">
        <property type="protein sequence ID" value="CAH37799"/>
        <property type="gene ID" value="BPSS0351"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0351"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6472"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FNDPERH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01108">
        <property type="entry name" value="HTH_CueR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011789">
        <property type="entry name" value="CueR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02044">
        <property type="entry name" value="CueR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="134" mass="15066" checksum="9A38259C164C44C4" modified="2004-10-25" version="1">MNIGEAAKVSGVSAKMIRYYESVGLLNPAKRTDSGYRVYHDDEIHLLRFIRQARRLGFLVDDIRKLLALWQDRSRASAEVKAIALEHVAELDGRIAELTDMRNTLVNLAAHCSGDDRPDCSILERLADPCCDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PA7</accession>
    <name>Q63PA7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194474.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110062.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0038"/>
    <dbReference type="EnsemblBacteria" id="CAH37481">
        <property type="protein sequence ID" value="CAH37481"/>
        <property type="gene ID" value="BPSS0038"/>
    </dbReference>
    <dbReference type="GeneID" id="56596787"/>
    <dbReference type="KEGG" id="bps:BPSS0038"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6041"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAMTHHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="307" mass="33548" checksum="F54D22091C137CE8" modified="2004-10-25" version="1">MSKSARNWGLEQIVAELRESREKLHRTRHPRGIRELPSRDAVCTIVSGLRASMFPTHYGAPDLTDETVDYYVGHTLESTLRLLAEQIRRALRFLPEHAQTPLAVLEERAFEIAREFGTQLPRIRALLVSDIQAAYTGDPAAQHITEILLCYPGVLAMMHHRLAHALYRLGVPLLARFINEIAHSATGIDIHPGAQIGPSFFIDHGTGVVIGETAIIGERVRVYQAVTLGAKSFPADGDGMLVKGNARHPIVEDDVVIYAGATILGRVTIGKGSVIGGNVWLTHSVPPGSSVAQGKIRESDKDQAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PD0</accession>
    <name>Q63PD0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110039.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0015"/>
    <dbReference type="EnsemblBacteria" id="CAH37458">
        <property type="protein sequence ID" value="CAH37458"/>
        <property type="gene ID" value="BPSS0015"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0015"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6011"/>
    <dbReference type="eggNOG" id="ENOG5032Z14">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIAWWIK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17167" checksum="A114D62CB8D10C9E" modified="2004-10-25" version="1">MPIFVVLFALAALIWGAIHMFEAIAARFGDAVAIGAATVAAVAIAAAIARSVRRRRDIAPNAREDGWTHVLQRAWGDLRISATKGLLWLSQDGADGRYTLTDLSGCRAETLDGRWYLVVAVRDDRRAEWKLPMDDKRDALRWARVLTLAKRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PQ3</accession>
    <name>Q63PQ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliD</name>
        <name evidence="8" type="ordered locus">BPSL3320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530401.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109916.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3320"/>
    <dbReference type="EnsemblBacteria" id="CAH37333">
        <property type="protein sequence ID" value="CAH37333"/>
        <property type="gene ID" value="BPSL3320"/>
    </dbReference>
    <dbReference type="GeneID" id="56527827"/>
    <dbReference type="KEGG" id="bps:BPSL3320"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1894"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGRQQIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="253"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="506" mass="49699" checksum="000F4C7D7FF10188" modified="2004-10-25" version="1">MSTPVTSTTQQQTNSALQQAAQSIISGSTGNSSMDVNSLVTALVNAKTAGQSAALSTSIATDQTTLSALGTLKAALTALQAGIGSLSDGTLTQKFTATATGTGLTATTGAGAVAGSYSVAVTQIATSQTLSSGAFNATQQLGTGTLTLSVGGKSTSISIDSTNNTLSGIAAAINSASNNPGVTATIVTGTDGAHLVLRSASTGAANVINVGVSNLSGDNGLSSLAVTSTASTTGGQSTIRSGGSVAWSQSTSAQDAEFTVGGIAASSASNAVSGAIAGVTLNLTQAAVGATQTLNVTTDTTAQATAITNVVNLYNTVITTMSSLSSLSGAGTSSQSAGPLLGDSTLNMIRNSLARVVGAGVTTGGSTTSLASIGIKFADGSSSSQTDGALTIDTAKLNAALQNSPSTVAALFNSTNGIGAQLNTTIQNYVQTGGVFDTRSNALNQDLKSLAQQQTRLASYASQLTSQYNAQFTALNTLMAQMNSNSNYLTQLFGGSNSSGAMANNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PV3</accession>
    <name>Q63PV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205284.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109865.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3269"/>
    <dbReference type="EnsemblBacteria" id="CAH37282">
        <property type="protein sequence ID" value="CAH37282"/>
        <property type="gene ID" value="BPSL3269"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3269"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1954"/>
    <dbReference type="eggNOG" id="ENOG5033MQG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDARFIC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="28883" checksum="A46E4C38053DDADB" modified="2004-10-25" version="1">MDRDEARALMAGLLGEQLMKFPLRWCKPAFFGIEPAPGEQVEVQNGTASLIVRGEDHFAITCRHVLDGFRAVRAESDRGFFHIGNCAIDPLAQLVIEGQRDLDVAVLWLTPEQAQHIVRDSDGIGESFFRVDQDRPAIIEEGNGVAFAGFPGVLRRHDAPQELNFGSYGCGATPVTAANDARFICQFERAEWVVRAVEAEPATIGGLSGGPAFLIKQSPAGLITYEFAGIIYEYSNDYELLYIVQAAAIFDLMHGGEALPPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PV7</accession>
    <name>Q63PV7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative plasmid conjugal transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205281.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109861.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3265"/>
    <dbReference type="EnsemblBacteria" id="CAH37278">
        <property type="protein sequence ID" value="CAH37278"/>
        <property type="gene ID" value="BPSL3265"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3265"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3721"/>
    <dbReference type="eggNOG" id="ENOG5031AZX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMSVARY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="14129" checksum="D5775DAB595C6503" modified="2004-10-25" version="1">MGTTVEVKAKNVTRKGCSPIKVYCLPEERAEIEAMANASGHSASTYLRLVGMGYRIQGVIDAEQVREMVRVNGDLGRLGGLLKLWLTNDARVAGFTPATIRALLSKIETMRDELSRIMEKVVRPRAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY5</accession>
    <name>Q63PY5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197900.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109833.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3239"/>
    <dbReference type="EnsemblBacteria" id="CAH37250">
        <property type="protein sequence ID" value="CAH37250"/>
        <property type="gene ID" value="BPSL3239"/>
    </dbReference>
    <dbReference type="GeneID" id="56594591"/>
    <dbReference type="KEGG" id="bps:BPSL3239"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1998"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="170"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="41079" checksum="5D291D8E20175B92" modified="2004-10-25" version="1">MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFIINAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYRHALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGADPNPAGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQEYLDAYRGEGIQHIALGAADIYRAVDGLRAKGVTLLDTIDTYYELVDRRVPNHGEPLDELRKRKILIDGAHDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PZ8</accession>
    <name>Q63PZ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">BPSL3226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525645.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109820.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3226"/>
    <dbReference type="EnsemblBacteria" id="CAH37237">
        <property type="protein sequence ID" value="CAH37237"/>
        <property type="gene ID" value="BPSL3226"/>
    </dbReference>
    <dbReference type="GeneID" id="60548034"/>
    <dbReference type="GeneID" id="66545606"/>
    <dbReference type="KEGG" id="bps:BPSL3226"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2012"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20921" checksum="7986A8DF2E55A381" modified="2004-10-25" version="1">MSDTPASPSGKRWYVVHAYSGMEKSVQRALQERIERAGMQDKFGQILVPTEEVVEVKGGHKAVTERRFFPGYVLVEMEMTDETWHLVKNTAKVTGFVGGARNRPSPISPREVEKIMSQMQEGVEKPRPKTLFEVGEMVRVKEGPFTDFNGTVEEVNYEKSRVRVSVTIFGRATPVELEFGQVEKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q04</accession>
    <name>RPOC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">BPSL3220</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521902.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109814.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q04"/>
    <dbReference type="SMR" id="Q63Q04"/>
    <dbReference type="STRING" id="272560.BPSL3220"/>
    <dbReference type="EnsemblBacteria" id="CAH37231">
        <property type="protein sequence ID" value="CAH37231"/>
        <property type="gene ID" value="BPSL3220"/>
    </dbReference>
    <dbReference type="GeneID" id="56527936"/>
    <dbReference type="KEGG" id="bps:BPSL3220"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2018"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000225518" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="900"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="903"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1412" mass="155992" checksum="EC55E124A0FEEF7B" modified="2004-10-25" version="1">MKALLDLFKQVQQEEIFDAIKIGLASPDKIRSWSFGEVKKPETINYRTFKPERDGLFCAKIFGPIKDYECLCGKYKRLKHRGVICEKCGVEVTLAKVRRERMGHIELASPVAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAYVVIDPGMTPLKARQIMTEEDYYNKVEEYGDEFRAEMGAEGVRELLRSINIDEQVETLRTELKNTGSEAKIKKYAKRLKVLEAFQRSGIKPDWMILEVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELKAPEIIVRNEKRMLQEAVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVIVVGPTLKLHQCGLPKLMALELFKPFIFNKLEVMGVATTIKAAKKEVENQTPVVWDILEEVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMEARTLMLASNNVLFPANGDPSIVPSQDIVLGLYYATREAINGKGEGLSFTGVSEVIRAYENKEVELASRVNVRITEMVRNEDTSEGAPQFVPKISLYATTVGRAILSEILPPGLPFSVLNKPLKKKEISRLINTAFRKCGLRATVVFADQLMQSGFRLATRAGISICVDDMLVPTQKETIVGDAAKKVKEYDRQYMSGLVTAQERYNNVVDIWSATSEAVGKAMMEQLSTEPVIDRDGNETRQESFNSIYMMADSGARGSAVQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVTQDLVVVEDDCGTSNGVAMKALVEGGEVVEALRDRILGRVAASDVVNPETQETLYEAGALLDETAVEDIERLGIDEVRVRTALTCETRYGLCASCYGRDLGRGSLVNVGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAVASSVEAKSNGTVRFTASMRYVTNAKGEQIVISRSGEALITDDIGRERERHKIPYGATLLQLDGAAIKAGTQLATWDPLTRPIITEYGGTVKFENVEEGVTVAKQIDDVTGLSTLVVIDVKRRGSQAAKSVRPQVKLLDANGDEVKIPGTEHAVQIGFQVGALITVKDGQQVQVGEVLARIPTESQKTRDITGGLPRVAELFEARSPKDAGILAEVTGTVSFGKDTKGKQRLVITDLEGNQHEFLIAKEKQVLVHDGQVVNKGEMIVDGPADPHDILRLQGIEALSRYIVDEVQDVYRLQGVKINDKHIEVIVRQMLRRVQIVDNGDTRFIPGEQVERSDMLDENDRMIAEDKRPATYDNILLGITKASLSTDSFISAASFQETTRVLTEAAIMGKRDDLRGLKENVIVGRLIPAGTGLAFHKARKAKEQSDRERFDQIAAEEAFEFGTPSAPAEEPQHPAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q26</accession>
    <name>RL6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">BPSL3198</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197947.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109792.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q26"/>
    <dbReference type="SMR" id="Q63Q26"/>
    <dbReference type="STRING" id="272560.BPSL3198"/>
    <dbReference type="EnsemblBacteria" id="CAH37209">
        <property type="protein sequence ID" value="CAH37209"/>
        <property type="gene ID" value="BPSL3198"/>
    </dbReference>
    <dbReference type="GeneID" id="56594558"/>
    <dbReference type="KEGG" id="bps:BPSL3198"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2040"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000265232" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="176" mass="18676" checksum="D7C14D468178DD1D" modified="2004-10-25" version="1">MSRVGKSPIALQGAEVKLADGAITVKGPLGTITQAVNPLVNVANNDGTLNLSPVDDSREANALSGTMRAIIANAVHGVTKGFERKLTLVGVGYRAQAQGDKLNLSLGFSHPVVHQMPEGIKAETPTQTEIVIKGIDKQKVGQVAAEVRGYRPPEPYKGKGVRYADEVVILKETKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q52</accession>
    <name>Q63Q52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555989.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109766.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3173"/>
    <dbReference type="EnsemblBacteria" id="CAH37183">
        <property type="protein sequence ID" value="CAH37183"/>
        <property type="gene ID" value="BPSL3173"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3173"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2066"/>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALAVDWY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="32550" checksum="00BE592522EC9E72" modified="2004-10-25" version="1">MQRRSWWSVGRRFAAGIDVNRRTVRIAVLSRRARGGAVRLEALDAEPLPAGAFDEPADADWAAVAAAMAAALGRVPPMRPAGWVRRTMASVMALPAGAFSSATLAWPRADAAAAVEPAVRAAAERLTGLARDALAVDWCVNDAGAASELVFATAAHVHLDVRIEAAASAGVELVAIDGEPPAALRAIRHVAAREVDSGEPYLGVWIGESGVHGWLVSADAVAAQIRYPAPEHADLADALRELARAGAPRCAFVAGDPEWLGGARISLADVGDLLGCIVLPFECAACGPLGAVDDGLAHSPGFAVAFGLALRGVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QA6</accession>
    <name>Q63QA6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative stringent starvation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20122" checksum="881D5671E73D9CCD" modified="2004-10-25" version="1">MRRRVRFRSRMAMQEISTKPYLLRALYEWCTDNGYTPHIAVRVDKSTRVPRQFVRDGEIVLNISFEATSQLQMGNEWIEFTARFSGKAHKLEVPVANVLAIYARENGQGMAFQVDVAAETGEADGSDALAVVEEGDDAGARHASADGAAEAAPEPGDAAEELPKSDGDGDGDGAKGSRPRLKIVK</sequence>
</entry>
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        <name evidence="4" type="ordered locus">BPSL3111</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="272560.BPSL3111"/>
    <dbReference type="EnsemblBacteria" id="CAH37122">
        <property type="protein sequence ID" value="CAH37122"/>
        <property type="gene ID" value="BPSL3111"/>
    </dbReference>
    <dbReference type="GeneID" id="56528076"/>
    <dbReference type="KEGG" id="bps:BPSL3111"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2131"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="28884" checksum="B1BB0FC2DFEBC416" modified="2004-10-25" version="1">MSYAPSLFGGNTPPPAPQTASSTDAGFQARSLVDLLYDGFFMLFLLKNGREPNDASEFGTRIQEFLSEFERGAKKLNIAADDVYAAKFAFCAAIDESVLSSPFKIRADWERRPLQLVLFGEQLAGEKFYQYLEECRAQGAARLQSLEVFHMCLLLGFQGKYLLEGPEKLAYLTARLGDEIANMKGKRAPFAPHWPLPDQISHRLKREVPLWAIGAVFALVGLLAFVGLNTYLKDSTVRALAPYSQVIKVGPESANLTISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QC5</accession>
    <name>Q63QC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">BPSL3098</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
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                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
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                <person name="Yeats C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="329" mass="36141" checksum="DA846F748E83B422" modified="2004-10-25" version="1">MTQTVQAQIAYFGKIPSRGDFVKSAHNPQLLQTLDHWIARAMELLADDPRWKIVYESAKPMHFAFLGSKSRLAIAGHMIASHDASNRRFPFLAATALEVDRPLTFLARSPLAFARLWSRAAAQMQSLLGPQEPPGALQALGDTQVPIDTGGPGSAHDGTFNDFVEHQTLFGLEQMLLASGHPVKLRGAMLALGSLLRPVMQSGTSHIERGLTLPLPTDPFYRSLVAAFWLELVAPFVSRADFELAIFIGTIAERERLIIGFNGASAKTLHSVVDPQTYAEHNIDIDDPEWIDAHAQNDHGISKLVSYLDQPQLSLRVCIDTFREAFAGA</sequence>
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<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
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            <taxon>Betaproteobacteria</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004204906.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109686.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37102">
        <property type="protein sequence ID" value="CAH37102"/>
        <property type="gene ID" value="BPSL3091"/>
    </dbReference>
    <dbReference type="GeneID" id="56594027"/>
    <dbReference type="KEGG" id="bps:BPSL3091"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2155"/>
    <dbReference type="OMA" id="AYNFGVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="76" mass="7600" checksum="1CE0033907A6DDBB" modified="2004-10-25" version="1">MQELNQQEIAMVGGASLLTNLVGAIGNEVLLLGQSAYNFGANLTDSAGAILTHTVDGVASALTSTIGIIQGVLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QE4</accession>
    <name>Q63QE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock-like protein CspD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspD</name>
        <name evidence="4" type="ordered locus">BPSL3079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196837.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109674.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3079"/>
    <dbReference type="EnsemblBacteria" id="CAH37090">
        <property type="protein sequence ID" value="CAH37090"/>
        <property type="gene ID" value="BPSL3079"/>
    </dbReference>
    <dbReference type="GeneID" id="56594052"/>
    <dbReference type="GeneID" id="66545794"/>
    <dbReference type="KEGG" id="bps:BPSL3079"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2175"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYSTIKM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="7344" checksum="A68922255D270C0F" modified="2004-10-25" version="1">MATGTVKWFNDAKGFGFITPEGGGEDLFAHFSEIRVDGFKTLQENQKVEFEVKTGPKGLQAANIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QG9</accession>
    <name>Q63QG9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549944.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109649.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3054"/>
    <dbReference type="EnsemblBacteria" id="CAH37065">
        <property type="protein sequence ID" value="CAH37065"/>
        <property type="gene ID" value="BPSL3054"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3054"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2211"/>
    <dbReference type="eggNOG" id="COG3025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SRHEWEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050355">
        <property type="term" value="F:triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039013">
        <property type="entry name" value="YgiF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39569">
        <property type="entry name" value="PTHR39569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="213" mass="22707" checksum="33B9207A660D1D74" modified="2004-10-25" version="1">MAIEQEIKLALPAAQVDAAQRFLDARAGAGGREITLVNVYFDTPALALARAKSALRLRRAPQGWLQTFKTAGAAAGGLHRRHEWEMPVAGEALEIDALCAACDVPSAVDALRAAAPQLIALFRTDFTRTLWHIEHAGATIEAALDRGEIVAQVSGDVRREPICEIELELVDGDAQALATLADQVAAALPGVTPDNLSKAQRGYRLRGGDLRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QP1</accession>
    <name>Q63QP1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">accB</name>
        <name evidence="7" type="ordered locus">BPSL2983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522044.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109577.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2983"/>
    <dbReference type="EnsemblBacteria" id="CAH36993">
        <property type="protein sequence ID" value="CAH36993"/>
        <property type="gene ID" value="BPSL2983"/>
    </dbReference>
    <dbReference type="GeneID" id="56528213"/>
    <dbReference type="KEGG" id="bps:BPSL2983"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2290"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IKSPIIG"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="157" mass="16052" checksum="BCB5D22691BB10E4" modified="2004-10-25" version="1">MDLRKLKTLIDLVSESGISELEVTEGEGKVRIVKNAPPVYVQPSAGFAPQVSAPAPVVTAPSEAAGAAAAAAAAAAAAPQGHVVTSPMVGTFYRAPSPGADPFVQVGDTVKEGQTLCIIEAMKLLNEIESDKAGVIKEILAENGQAVEYGQPLFVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ5</accession>
    <name>Q63QZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Paraquat-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lpw206-207</name>
        <name evidence="4" type="ordered locus">BPSL2879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109473.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2879"/>
    <dbReference type="EnsemblBacteria" id="CAH36889">
        <property type="protein sequence ID" value="CAH36889"/>
        <property type="gene ID" value="BPSL2879"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2879"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3285"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HHVEIKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="553" mass="59976" checksum="39979BC515B5CCBA" modified="2004-10-25" version="1">MLMNRPQGPQHDPNAAPPTPPGGEPPVLPEPVITRRSGWLPSLVWLVPLVAALIGIGLVVKSVLERGPEITISFKSAEGLEPGKTQVKYKDVEIGMVETIKLSKDLSHVLVEVQLKKEAEDFAVKGTRFWVVRPRIGATGVSGLGTLLSGAYIGVDAGRSDETEKSFTGLETPPAVTGDQKGTQYVLRGDSLGSIDIGSPVYYRRVQVGQVVGFSLDKDGTGVTFRVFVNAPYDQYVGLNSRWWQASGVDLRLDSSGFKLNTQSLATVILGGIAFQSPPNQAAGPPAPNNMTFRLGADEGDAMREPDGEPVQVVMNFNQSLRGLSVGAPVDFRGIVLGQVTNIGIDFDPKTKNFTMPVTMNVYPDRLGRKFREASQDKGYAARREVLSRLVQHGLRGQLRTGNLLTSQLYVALDFFPKAPPVKIDLAREPVELPTVPNTLDELQLQVADIAKKLDKVPFDQIGANLNSALANADKLFKRLDTEIAPEARDTLSAAKQTFTTAEATLQQDSPLQSDVRGALKELTRTLQSLNALADYLERHPESLLKGKPGDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R07</accession>
    <name>Q63R07_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">recG</name>
        <name evidence="10" type="ordered locus">BPSL2867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109461.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2867"/>
    <dbReference type="EnsemblBacteria" id="CAH36877">
        <property type="protein sequence ID" value="CAH36877"/>
        <property type="gene ID" value="BPSL2867"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2867"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3270"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="334"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="537"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="748" mass="80462" checksum="FF3BA34CE0F29C55" modified="2004-10-25" version="1">MPAAAQAARAPRAPRAAPPDALPADTPPASAAKPAKRAAKAASKTVSKAAADAAGAQAAPKAVKTADKLAKLGLTRDIDLVLHLPMRYEDETTLTPMRELLPGETAQTEGVVFDSEIAYRPRRQLLVKLRDDDGAELVLRFLNFYGSQVKQMAVGQRLRVRGDVRGGFFGLEIVHPTVKTVDEDAPLPQALTPVYPSTAGVSQAYLRKAIDNALARTPLPELLPPEIARAYLQPLDVPPLADAVRMLHHPGVGADEAALIDGTHPAWTRIKFDELLAQQLSLKRAHEERRTRAAPAMPRRARDDGAALSARLHAALPFALTAAQERVVAEIAHDLTQPHPMQRLLQGDVGSGKTVVAALAAAQAIDAGYQAALMAPTEILAEQHARKLRGWLEPLGVSVAWLAGSLKAKDKRAALEAAALGTAQLVIGTHAMIQDTVEFARLGLVIVDEQHRFGVEQRLALRAKAANAADGAAGFQPHQLMMSATPIPRTLAMTYYADLDVSTIDELPPGRTPILTRLVSDARRDEVIGRVREAALAGRQVYWVCPLIEESETLQLQTAVETYETLAAALPELKVGLVHGRLAPAEKAAVMDAFSRNDVQLLVATTVIEVGVDVPNASLMVIEHAERFGLAQLHQLRGRVGRGTAASVCVLMYSGPLSIAGRARLKTMRETTDGFEIARRDLEIRGPGEFLGARQSGAAMLRFADLENDGWLIEPARDAAARLIAAHPEVVAQHLARWLGAREQYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R91</accession>
    <name>Q63R91_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109377.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2782"/>
    <dbReference type="EnsemblBacteria" id="CAH36791">
        <property type="protein sequence ID" value="CAH36791"/>
        <property type="gene ID" value="BPSL2782"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2782"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3176"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRRHARW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="226"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="37328" checksum="69D04A8979C69C42" modified="2004-10-25" version="1">MECAFNIGRMGAHVSRGAAFGGVCYRKGIAVVLFGGFSLMQAGRMAEIFNLANRFRHAGEDSGGYEMLLLSATGGAVYSSSGIPVWTQPLHERAIERVHAIFAIGEPDAADRDDEKVSEWLRSARAHVRASGGARRLMGLAALERGDAAADDLSIDAMLSGAASAEKVRPTAAERAAFSAALAIIRHDCGDSAAHEVAERLCPALSARPAESAFAAREARASKLIRASVQQLRDNSANRISIADTAHAAAMSERNFLRRFKQEIGVTPSEFVQKVRLEHACHMLVHTDLPVDKIARRTGLGSGDRLAKLFRQHLSMSPTEYRAIERSRGADADLACGDFVSRLSGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RH0</accession>
    <name>Q63RH0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109298.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36710">
        <property type="protein sequence ID" value="CAH36710"/>
        <property type="gene ID" value="BPSL2702"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2702"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3082"/>
    <dbReference type="eggNOG" id="ENOG5032QB6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYGGQHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="322" mass="33319" checksum="42EC7E08BE1F4560" modified="2004-10-25" version="1">MRTAAWLRYLLDHAERFAAAAASSREARVAAAARDTLAKAGAHARREPAADAGLLLNELLAALEGDGASVDEARGNAYGELARTPPKRLLAAVDRYLPGSKAVFDGAHGVADVLGYDDAELGWAALDSIELGIGHALASDGEAADDAMRGIAAFEGPAAGRVIDRAIGRIWGADEKRADALSALAAFSATLAMNAPITLDAYGGEHNGVAAAILRERGDLASAPGLLAALAVCRLDRLTGAGSFWAYYLLAGVMIAAPQAVASIAARFHRDALSAWLDMLLAVPARSPIGDAGEAALARLAASMSFTSRHNPIVHTRHRSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RH4</accession>
    <name>Q63RH4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="5" type="synonym">groES1</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">BPSL2698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186661.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109294.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63RH4"/>
    <dbReference type="STRING" id="272560.BPSL2698"/>
    <dbReference type="EnsemblBacteria" id="CAH36706">
        <property type="protein sequence ID" value="CAH36706"/>
        <property type="gene ID" value="BPSL2698"/>
    </dbReference>
    <dbReference type="GeneID" id="62010241"/>
    <dbReference type="KEGG" id="bps:BPSL2698"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2644"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RSINMTI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="10490" checksum="BA5E8E4E9207063D" modified="2004-10-25" version="1">MNLRPLHDRVIVKRLDQETKTASGIVIPDAAAEKPDQGEVLAIGPGKRDDKGAPIALDVKVGDRVLFGKYAGQTVKVDGQELLVMREEDIMAVVNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ2</accession>
    <name>Q63RZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent formate dehydrogenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fdsB</name>
        <name evidence="7" type="ordered locus">BPSL2529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189204.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109125.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2529"/>
    <dbReference type="EnsemblBacteria" id="CAH36536">
        <property type="protein sequence ID" value="CAH36536"/>
        <property type="gene ID" value="BPSL2529"/>
    </dbReference>
    <dbReference type="GeneID" id="56596428"/>
    <dbReference type="KEGG" id="bps:BPSL2529"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2850"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRMLMEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="521" mass="54267" checksum="1388C55409984626" modified="2004-10-25" version="1">MSTRIHVPRDSAALAVGADALARAIEAQAAARGIAIELVRNGSRGLLWLEPLVEVSTPAGRIGYANLTAADVPALFDAGWLDGAAHPACVGIVDEIPYLKRQQRLTFARIGITDPLSIDDYVAHGGLEGLRNALALDGAAACETLVESGLRGRGGAAFPAGVKWRTVREAAAAQKYVVCNADEGDSGTFSDRLVMESDPYCLIEGMIIAGIATGATVGHIYVRSEYPHAIAALGEAIARARAAGWLGASVLGTAHAFELHVAKGAGAYVCGEETALLESLEGKRGVVRAKPPLPALSGLFAKPTVINNVITLATVPIIFARGAAFYRDYGMGRSRGTLPFQLAGNVKRGGLVELAFGVTLRELLFDFGGGTASGRPARAAQVGGPLGTYLPEGQWDIPLDYEAYAAVGAVVGHGGIVLHDDTSNLAELAEYAMHFCALESCGKCTPCRIGSTRGVETIARIRAGDTSERQVRLLRDLCDTMTAGSLCAMGGMTPYPVLSALDHFPEDFGLAAHASHAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S76</accession>
    <name>Q63S76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske iron-sulphur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193415.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109041.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2449"/>
    <dbReference type="EnsemblBacteria" id="CAH36452">
        <property type="protein sequence ID" value="CAH36452"/>
        <property type="gene ID" value="BPSL2449"/>
    </dbReference>
    <dbReference type="GeneID" id="56596364"/>
    <dbReference type="KEGG" id="bps:BPSL2449"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2791"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLNQCAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="131" mass="14253" checksum="77D82E5982386DBA" modified="2004-10-25" version="1">MTGDGDARFVCAADALVDGGEGVRLDATLRGEPAVVFFVRYAGRAYGYLNRCAHVPMELDWIEGQFFESSGLYLMCATHGAIYEPETGKCVGGPCRGARLRAVRVDERDTPDGRAVFWLPDGDLRPAPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SI8</accession>
    <name>Q63SI8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108928.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2332"/>
    <dbReference type="EnsemblBacteria" id="CAH36335">
        <property type="protein sequence ID" value="CAH36335"/>
        <property type="gene ID" value="BPSL2332"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2332"/>
    <dbReference type="eggNOG" id="ENOG5032S82">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYESFAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="32554" checksum="CEF683A912751982" modified="2004-10-25" version="1">MTILKVGPSLKDNDVLWRYLPLDKFIDLVESKTLFFAPLAWFSKTDPFEGYAPQVAINAMASVSKKFRDQQLEAINQVESNIPQGVSPQELQKIKMQLQQLRKNAESHLPTMREIFKNISACTMVNCWYKSDHESEGMWGLYSKGGVAIRTSVGALRRALNQGEEAPVIHIGSIKYLDFSDPNLKPSDCVTEDGQMIGMIKRIAYAHEKEVRMYIARERAGDSLDLLAPESTRVSVNVQGMLESVVISPFAGEAIERSVRAVCRWSGVSESIVSRSNLLDNCEFLLDAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SL4</accession>
    <name>Q63SL4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase IV</fullName>
            <shortName evidence="12">Pol IV</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dinB</name>
        <name evidence="15" type="ordered locus">BPSL2306</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2306"/>
    <dbReference type="EnsemblBacteria" id="CAH36309">
        <property type="protein sequence ID" value="CAH36309"/>
        <property type="gene ID" value="BPSL2306"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2306"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3119"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KVRRYDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="14">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="12">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH36309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="406" mass="44076" checksum="9046163C365722DC" modified="2004-10-25" version="1">MPPSDPPPPPSGDAAHLARKIIHCDCDCFYASVEMRDDPSLRGRPLAVGGRPDQRGVIATCNYDARRYGVHSAMSSALAMRKCPDLLILPPAMDKYRAASRLIMAIYRDYTPDVEPLSLDEAYLDVSRATRCQGSGTLIAREIRERVRDTVGVTVSAGVAPNKFIAKIASDWNKPDGLFVVRPHEVDAFVAALPVRKLHGVGKVTAARLDKLGIRTCAQLRDWSLFDLHRTFGAFGRRLHELARGIDERPVRADQARKSVSVETTYVQDLAALDACAAEIRRLTGLLDARIERAGAARSIRKLYVKIRFADFQRTTVECVADATDADTAVALLAKGLARRRQAVRLLGVGVRIDEDTAERHGQIALFDDEDMSDESAEGDEGGEVGEGGEGGEDGEGDEGDASPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SW0</accession>
    <name>Q63SW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938036.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108806.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2211"/>
    <dbReference type="EnsemblBacteria" id="CAH36213">
        <property type="protein sequence ID" value="CAH36213"/>
        <property type="gene ID" value="BPSL2211"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2211"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3235"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFYKHFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="188" mass="20478" checksum="08AF62E0486B8A22" modified="2004-10-25" version="1">MRYSPKHKEASRARLVEAGAALAKRNGFANTGMDALTAAAGVTTGAFYSQFRSKPEFLYAIVEHEMSKVLATVENRSKDDLVATLRSYLSTAHADHPELGCPVPTLGAEIARADIATRRMFEDLIKRFQASLATALHDDEAAWTLGCAAIGAVLVARAMASTERRSEVLRSVLAYTMRSFDADARKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SZ0</accession>
    <name>Q63SZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="5">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thiD</name>
        <name evidence="5" type="ordered locus">BPSL2181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.7" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534771.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108776.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2181"/>
    <dbReference type="EnsemblBacteria" id="CAH36183">
        <property type="protein sequence ID" value="CAH36183"/>
        <property type="gene ID" value="BPSL2181"/>
    </dbReference>
    <dbReference type="GeneID" id="56529013"/>
    <dbReference type="KEGG" id="bps:BPSL2181"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3270"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KDEVGYA"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="269" mass="27470" checksum="2F8CCEBC626D6E5D" modified="2004-10-25" version="1">MTRPIPNALTIAGSDSGGGAGIQADLKTFSALGAYGASVITALTAQNTRGVTGVHAPDAGFVSAQLDAVFDDIRIDAVKIGMLANAAIVRAVAAALTRHAPRHVVLDTVMISKSAHALLAPDAVDALRNELLPLADLVTPNLPEAAALLGVAAATTEDDMVRQGETLVARGAKAVLMKGGHLGAERESPDWLIHAGGAQRFAGARLPVANTHGTGCTLSSAIAALLPQRATLAEAIADAKIYLTGAIGASGQLDVGHGVGPVHHFYRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TK8</accession>
    <name>Q63TK8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192152.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108558.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1960"/>
    <dbReference type="EnsemblBacteria" id="CAH35959">
        <property type="protein sequence ID" value="CAH35959"/>
        <property type="gene ID" value="BPSL1960"/>
    </dbReference>
    <dbReference type="GeneID" id="56595502"/>
    <dbReference type="KEGG" id="bps:BPSL1960"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4108"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GALPHMY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="27711" checksum="56DE1369B0C02422" modified="2004-10-25" version="1">MGRSINLEGKVALITGASSGLGQRFAQVLSQAGAKVVLASRRVERLKELRAEIEAAGGAAHVVSLDVTDYQSIRAAVAHAETEAGTIDILVNNSGVSTMQKLVDVSPADFEYVFDTNTRGAFFVAQEVAKRMMMRAGSGNAKPACRIINIASVAGLRPFSQIGLYAMSKAAVVHMTRAMALEWGRHGINVNAICPGYIDTEINHYLWETEQGQKLQSMLPRRRVGKPQDLDGLLLLLAADESQFINGSIVSADDGLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U54</accession>
    <name>Q63U54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-3b C17-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cobJ</name>
        <name evidence="8" type="ordered locus">BPSL1762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.131" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526968.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108362.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1762"/>
    <dbReference type="EnsemblBacteria" id="CAH35761">
        <property type="protein sequence ID" value="CAH35761"/>
        <property type="gene ID" value="BPSL1762"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1762"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3863"/>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMHDFCA"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiG_N" evidence="7">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="368"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="616" mass="63660" checksum="D42AC427C080C0A5" modified="2004-10-25" version="1">MTAAPAIVILGPGALETARRIQARFDGARVHALAGRAEADLAFAELGPHLRELYARGAPIVALFAAGIAIRCVAPCLADKGAEPPVLAVAEDGSAVVPLLGGLAGANALAREIADALGVAAAITTSGELRFGACMLNPPEGYALADLDAGKRFVSDLLAGESTRVEGDARWLDDVALPRDAHAARVIRVTPHASRGDAHALLIHPRSVVVALGDGDGDIDGEGLRDDARSVSAPDATGRARANAAAPARAASPDLPPLAARIAAALAAHDLAPLALAAVVAPARRIAEHALTDAARALRAPLRFVETNARDAAGVLDAALPAALAPRVDASRAAAGSPRTTPPEPRDVAIAVARAPVDADALGIARGRLTVLGLGPGRADLMTPAARAALADATDIVGYATYVNMAGPLRADQQLHVSDNREELQRARHAFELAARGRRVAVVSSGDPGVFAMAAAVLEALDGADDARWAAVELDVVPGVSAALATAAEAGAPLGHDFCLISLSDNLKPWAIIEKRIDHAAAADFALAFYNPVSRARPVQFDRALDIVRRHRAPETVVVLGRDIGRPGATLATTTLAALSAQQVDMRTMVIVGSSTTRRVARDGARDWVYTPRWYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U59</accession>
    <name>CBID_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cbiD</name>
        <name type="ordered locus">BPSL1757</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108357.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63U59"/>
    <dbReference type="SMR" id="Q63U59"/>
    <dbReference type="STRING" id="272560.BPSL1757"/>
    <dbReference type="EnsemblBacteria" id="CAH35756">
        <property type="protein sequence ID" value="CAH35756"/>
        <property type="gene ID" value="BPSL1757"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1757"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3857"/>
    <dbReference type="eggNOG" id="COG1903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YHGKLIK"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000257752" description="Cobalt-precorrin-5B C(1)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <sequence length="363" mass="37595" checksum="5D60C1CEE45C3275" modified="2004-10-25" version="1">MRDETPEQPAPLRFGYTTGSCASATSLAAARLLLTGVASDTVDIVLPKGQHVAMRLAFCRATDDGGAEAGTIKDAGDDPDVTHGALVFARVRLVHEPGVRFRAGPGVGTVTRAGLPIAVGEPAINPVPRRMMTEHLAALAAEHGYAGGFDVAIGVENGEALARKTMNPRLGIVGGLSILGTTGIVRPFSCSAYIASIHQGIDVARANGVTHIAACTGNASEDAVRARYGLPDIALIEMGDFAGAVLKYLRRASVARLTLCGGFGKLSKLAAGHLDLHSRHSSIDLPLLAEWAGEAGASAVLQHEIRAANTSQQALALALAHHVPLGDVVCAHARRVARDIVPGEVDVETLAIDREGRIVGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UF7</accession>
    <name>Q63UF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527056.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108259.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1649"/>
    <dbReference type="EnsemblBacteria" id="CAH35646">
        <property type="protein sequence ID" value="CAH35646"/>
        <property type="gene ID" value="BPSL1649"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1649"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3724"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WSGGAQS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266336" evidence="1">
        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="37406" checksum="1BD08881FA9B34BD" modified="2004-10-25" version="1">MNSKSVFRQATLMAVCATAFAAAGAQAADSIVFTSWGGTTQSSQDKDWAKPFTKATGINVMMDGPTDYGKLKAMVDSGNVTWDVVDVEGDFAYAAQKAGLIEPIDYSVVKKDELDPRFVSPAAVGSFYYAFVLGFNKASFKGAQPSTWADLFDTKRFPGKRTFYKWSAPGVLEIALLADGVPVNKLYPLDLDRAFKKLDSIKSDIVWWGGGAQSQQLLASGEAPIGMFWNGRLHALEQTGVPVGISWTQNLTAADMLVIPKGAKHRAEAMKYLAAVTSADAQAKFAADTGYAPINMKSPSMMPAAVAKTLPDQYKSSQIDLDMKYWADHRDEIAKRWYAWQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UP2</accession>
    <name>Q63UP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative metal-ion transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544505.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108174.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1554"/>
    <dbReference type="EnsemblBacteria" id="CAH35555">
        <property type="protein sequence ID" value="CAH35555"/>
        <property type="gene ID" value="BPSL1554"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1554"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3600"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QCLCAKL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="435" mass="45108" checksum="C9A80796FEF7FF9F" modified="2004-10-25" version="1">MNSRPLAARSPSSRRPSASGGPGGGRRWAAFVGAGVLVAVGYMDPGNWATALAGGAGYGYALLGVVIAASLMAMLLQWLAARIGVVSGRDLAQLCRERFDPRATVLLWIAAEIAIVACDVAEVVGAAVALQMLLGVSLSTGVLVSAVGTLAMLALERHGRRTLEAAIASLIFFVGLCFVIEVALARPDWHAALAGAAPSPRLLREPGMLWLAAGILGATVMPHNLYLHSMLVKHHASARDEPSIRRALFGVNLDTFVSLGFAFVINAALLIVAAAVFHASGHDDVTDLADAHRLIAPLVGNRWAGPLFAAALLACGLSATVTGTLAGQAIMEGFLKLTLPRWQRALLTRALAIGPALAAVGLFGQHGSNQLLVASQVVLSLQLPLAMVPLVVFASSRALMGRWRVRGLPLAAAWMCAAAIVALNGALVWQVVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UW7</accession>
    <name>Q63UW7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA</name>
        <name evidence="9" type="ordered locus">BPSL1479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108099.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1479"/>
    <dbReference type="EnsemblBacteria" id="CAH35480">
        <property type="protein sequence ID" value="CAH35480"/>
        <property type="gene ID" value="BPSL1479"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1479"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1661"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKPLMHG"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="187"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="45763" checksum="949589DA4001743D" modified="2004-10-25" version="1">MSHPTPQTPRVPMLSTADALTALLAAARPLAEIETVPTLEALNRVLAADVASGLDVPPMNTSAMDGYAVRIADLTRGERRLPVSQRIAAGHPAAPLAPGTAARIFTGASVPAGADAVVMQEQTEAAGDQVDILHTPTVGEWITAQGADIRRGSVILPAGTRMTPQAMGLAASVGCASLAVTRRVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCDVTDYGIVPDRLDATRAALREAAREHDVIVTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAIRRDGAAAVEATAHGASDAGDTRAMHATSGGEAYFIGLPGNPVSSFVTFLLFVRPFLLRVAGAAQVAPRAVSLRADFTQNKADRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHAISAGETVRFIPFSELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VA4</accession>
    <name>Q63VA4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107962.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1337"/>
    <dbReference type="ESTHER" id="burma-a5j5w8">
        <property type="family name" value="UCP037442"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35335">
        <property type="protein sequence ID" value="CAH35335"/>
        <property type="gene ID" value="BPSL1337"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1337"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1500"/>
    <dbReference type="eggNOG" id="COG4757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRYFFDD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017208">
        <property type="entry name" value="UCP037442_abhydr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037442">
        <property type="entry name" value="UCP037442_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="62"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="33878" checksum="796456009289EE0D" modified="2004-10-25" version="1">MHNSRSIARMSMHERPPITAETTWFAARDGRLLTGTFYAPGAPSASNGRSVLVSGALGVPRGFYERYARFLASDGFTVLTYDYRGIGDSRKPPAEADGASLRDWGEADLPGALDHLAARAPSHRLLAVAHSVGGQLFGLAHNNGRAAALLSICCPSGYWRLWPWPHRLWLAPLWFCVVPALGGVLSHLPVRRAGLGFAADLPAGVMREWARWCRHADYLVDDEGHPLREHFRGYRGRILAYTVSDDWMAPPAAVQALHRFYSTAQVEHREIAPDRRRHAIGHFGYFRDDNRALWPLGAAWLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VC3</accession>
    <name>Q63VC3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nitrite/sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553995.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107943.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1319"/>
    <dbReference type="EnsemblBacteria" id="CAH35316">
        <property type="protein sequence ID" value="CAH35316"/>
        <property type="gene ID" value="BPSL1319"/>
    </dbReference>
    <dbReference type="GeneID" id="56526520"/>
    <dbReference type="KEGG" id="bps:BPSL1319"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.171"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGPHTIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="142"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="375"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="493"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="605" mass="67182" checksum="4F38B0B6EA3423AD" modified="2004-10-25" version="1">MYRYTEFDKAFVRNRAAQFRDQLERWRQGALSEDAFRPLRLQNGWYVQRHAPMLRVAVPYGELSSAQIRMLARIARDYDVPEPARYRAACDAQARLGTVRLPTRNAHFTTRTNVQFNWIPLEKAADVMDLLATVDMHGIQTSGNCIRNISCDERAGVAPDEIADPRPFAEVMRQWTTLHPEFAFLPRKFKIAITGAADDRAATDWHDVGLRLVRDAAGELGFRVSVGGGMGRTPMTATLVRAFVPWRHVMNYIEAIVRVYNRYGRRDNRYKARIKILVKAEGQRYIDDVDEEFRQIVEHDGGPHTIEQAEFDRVGASFVPPVPPPCAAGRHAKTDIDADMDAALARMRTLAGAQPAFARWLERNVAPHRDPARRIVTLSFKRRHQAPGDASPEQLDALAHLAERFSAGEARVTHAQNVVLPWVRAIDLHALWEAARDAGLASANVRLLTDMIACPGGDFCALANARSIPIADAIAERFDDLDELHDIGDVDLHVSGCINSCGHHHSGHIGILGVDKDGDEWYQVTLGGSDGTAANGPAQPGKVIGPSFSADEIVDVVDALVATYLRVRRTEAGRVERFIDAYRRVGPEPFKAAANAARHPETSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VC7</accession>
    <name>Q63VC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553993.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107939.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1315"/>
    <dbReference type="EnsemblBacteria" id="CAH35312">
        <property type="protein sequence ID" value="CAH35312"/>
        <property type="gene ID" value="BPSL1315"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1315"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.176"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFDVQHL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="33141" checksum="950914AB1CA0095C" modified="2004-10-25" version="1">MDRIDLFRVFARVVECANFTRAADTLGMPRSSVSAAIQELEGRVGARLLHRTTRKVTPTQDGAALYERCLRLIADVEETENLFRHSIVGPSGTLRVDMPGRIGRLIVAPALPEFLERYPQISVELGVTDRAVNLIEERVDCVLRVGTLSDSGLVARAIGDLPLINVASPAYLARHGVPRTPADLERHRPVNYASPSNGRVAPWEWVEGDEVKRVALRARVTVNSAEAYIACCLAGLGLIQIPAYDVNAHLRAGELVEVLPDHRAAPMPMTLLYPHRQHLSRRFQVFAEWLEALLRAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VK3</accession>
    <name>Q63VK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family M14 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526471.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107863.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1242"/>
    <dbReference type="EnsemblBacteria" id="CAH35236">
        <property type="protein sequence ID" value="CAH35236"/>
        <property type="gene ID" value="BPSL1242"/>
    </dbReference>
    <dbReference type="GeneID" id="56526620"/>
    <dbReference type="KEGG" id="bps:BPSL1242"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.283"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAYFEPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="114"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="384" mass="43075" checksum="9ECFA3680859FB9F" modified="2004-10-25" version="1">MTLSITSNFDAGAIDVVSCERADAIRLRVRGDNRSEFAQWFYFRLTGARGERCVMTFENANDCAYPAGWRDYRAVASYDRVNWFRVPTSYDGQMLTIDHTPEFDSIHYAYFEPYSEERHSEFLGAVQQMPQASVVELGRTVEGRPMSLVVLGTPDEAGAAKKKVWIIARQHPGESMAEWFIEGLVKRLVGWGDWSGDPVARKLYDHATFYVVPNMNPDGSVHGNLRTNAAGANLNREWMEPDAERSPEVLVVRDAIHAIGCDLFFDIHGDEDLPYVFAAGSEMLPGFTEQQRVEQSAFIDSFKRASPDFQDEHGYPPGKYREDALKLASKYIGHRFGCLSLTLEMPFKDNANLPDEHVGWNGARSASLGAAMLGAILEHVRAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VN4</accession>
    <name>Q63VN4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ordered locus">BPSL1210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185627.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107832.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1210"/>
    <dbReference type="EnsemblBacteria" id="CAH35205">
        <property type="protein sequence ID" value="CAH35205"/>
        <property type="gene ID" value="BPSL1210"/>
    </dbReference>
    <dbReference type="GeneID" id="56595143"/>
    <dbReference type="KEGG" id="bps:BPSL1210"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.316"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIHLMIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="125" mass="11999" checksum="EF15D1696199C2C7" modified="2004-10-25" version="1">MPYLKVLIIVVQLLSALGVIGLVLLQHGKGADMGAAFGSGASGSLFGATGSANFLSRTTAVLATIFFVATLALTYLGSYKSAPSVGVLGAAPAPAASAPAASQTPAASAPAAVSAASAPGQDVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VV8</accession>
    <name>Q63VV8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936854.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107758.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1137"/>
    <dbReference type="EnsemblBacteria" id="CAH35131">
        <property type="protein sequence ID" value="CAH35131"/>
        <property type="gene ID" value="BPSL1137"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1137"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.405"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYHLAWM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="363" mass="41389" checksum="64E8A1965BC8EDF5" modified="2004-10-25" version="1">METISVFNNKGGVGKTTLTFHLAHAFAELGLRTLLIDLDPQCNLTILSMDAEELHRIWQEEDPFIEDFEAAKNAMPATEFKGISSAPRSIHFILKPTEDGVSDLDDVSPPWNLAPSLDLIPGRLTLHMYEDRLANRFPQAYQGDPLAIRTLTKFRSVAEAYSHRYKYDIVIFDTSPSLGMLNKVIISTTDGLVIPCMPDMFSLYGIRNIGNSLRAWKSQFDSLYTLLTKDKRRQFPDEYVRLLGYTIYNSKKYSSRNKWDLATAHYNYAMQIPPTIREYIGEQVLGHLTDEQLDEPIGGTSVMHTHNTLPNMAQKYHVPMWKVPSCKSLETDDISTIFGNRTTYEATREKYVGFAKDLLARMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W58</accession>
    <name>Q63W58_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisQ</name>
        <name evidence="7" type="ordered locus">BPSL1032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522525.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107658.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1032"/>
    <dbReference type="EnsemblBacteria" id="CAH35027">
        <property type="protein sequence ID" value="CAH35027"/>
        <property type="gene ID" value="BPSL1032"/>
    </dbReference>
    <dbReference type="GeneID" id="56526807"/>
    <dbReference type="KEGG" id="bps:BPSL1032"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.536"/>
    <dbReference type="eggNOG" id="COG4215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWEYIEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030199">
        <property type="entry name" value="HisQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30133:SF1">
        <property type="entry name" value="PTHR30133:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="14"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="25228" checksum="CA3BA86720D92A9D" modified="2004-10-25" version="1">MFLQGYGPLILSGTWQTVKLAVLSLALSFLLGLVGAAAKLSRNRVSNGIGTLYTTLIRGVPDLVLMLLLFYSLQIWLNQLTDLMNWDQIDIDPFAAGVLVLGFIYGAYFTETFRGAFLSVPRGQLEAGSAYGMTNWQVFARVMFPQMMRFALPGIGNNWQVLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLLAGAIYLAITTISNFVLMWLEKRYSTGVRKADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W80</accession>
    <name>Q63W80_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported fimbriae-related chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191842.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107636.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1008"/>
    <dbReference type="EnsemblBacteria" id="CAH35004">
        <property type="protein sequence ID" value="CAH35004"/>
        <property type="gene ID" value="BPSL1008"/>
    </dbReference>
    <dbReference type="GeneID" id="56596181"/>
    <dbReference type="KEGG" id="bps:BPSL1008"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.561"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVRTYRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266639" evidence="1">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="25258" checksum="3DDAD0DB2EF73A29" modified="2004-10-25" version="1">MTTSAHCWLAALTLAGAVAPASGATLQISPVTVEMAADNPAAGVTLSNPGARPVYGQVRTFRWTQEQGDDMLAPAPELVASPPLVQIGGQGEQLVRLVRVAHDKPRREESYRVLIDELPTPDAPVVNGIAIRLRYSIPVFVVPDVALGPPKLTWRIVHGATGWLLRVTNDGERHAQLASVRLVDDAGKAYEIAPGLLGYALAGGMRQWPLRIDAARIRKVRAAINTRPVEADVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W82</accession>
    <name>Q63W82_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ordered locus">BPSL1006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191886.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107634.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63W82"/>
    <dbReference type="STRING" id="272560.BPSL1006"/>
    <dbReference type="EnsemblBacteria" id="CAH35002">
        <property type="protein sequence ID" value="CAH35002"/>
        <property type="gene ID" value="BPSL1006"/>
    </dbReference>
    <dbReference type="GeneID" id="56596183"/>
    <dbReference type="KEGG" id="bps:BPSL1006"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.563"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="371"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="51173" checksum="9DEA731475F7D25B" modified="2004-10-25" version="1">MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGFTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDFAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDARGIDLADLTLDEMKQELPNVAHLIGEDVFDYLTLEGSVASRNHPGGTAPDQVRAAAKAARAALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W91</accession>
    <name>Q63W91_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526322.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107625.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0997"/>
    <dbReference type="EnsemblBacteria" id="CAH34993">
        <property type="protein sequence ID" value="CAH34993"/>
        <property type="gene ID" value="BPSL0997"/>
    </dbReference>
    <dbReference type="GeneID" id="56526838"/>
    <dbReference type="KEGG" id="bps:BPSL0997"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.574"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEFGCFK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="125"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="36855" checksum="175E385D116EF129" modified="2004-10-25" version="1">MTHTFPRYDDAAAFEVATNLFVYPAMLIAHRLGLFERLGEGPRTLDEIGAALGLARRPAEALVNASAALGFVRRDGDRFALTARARDLLLPASRQYFGAFWDLMYDNGDTFSIAGLEAALRGDAPHVYGETDVFDSHRRHEALGMRFTRAMQSLSASHAMVWPTKLDLARHRVMLDVGSGSGANAVGALSAWPALRAVLFDLPAVCELAATFVDARWRERVTLHPGDMWHDPFPAADLHFYSNVFHDWPADKNAALARKSFDALPSGGRIVLHEVLYRDDRGGPLAAAGYSLMMIGWTQGEQYTSRELRAMLGGAGFASIETIPSGGYFSLVTGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WC4</accession>
    <name>Q63WC4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system permease protein LptF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192178.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107592.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0964"/>
    <dbReference type="EnsemblBacteria" id="CAH34960">
        <property type="protein sequence ID" value="CAH34960"/>
        <property type="gene ID" value="BPSL0964"/>
    </dbReference>
    <dbReference type="GeneID" id="56596228"/>
    <dbReference type="KEGG" id="bps:BPSL0964"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.613"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELQWRIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030922">
        <property type="entry name" value="LptF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04407">
        <property type="entry name" value="LptF_YjgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="40675" checksum="43413C0A1E5ED153" modified="2004-10-25" version="1">MIFERSLQRELAYTAGAVFMVLLTIMLTSMMIRIVGYAASGEVNPKDVLVLIGLTVIGYLAMILVGTLFVSILFVLTRWYKDSEMVVWLASGVSLTRLIKPIGVFATPIVILIAFFAFVGWPWSNQQSKLIKARFQQRDEVSLLAPGQFRESAANHRVFFIEKMSPDQAKVQNVFVTTTEHGKVNVVVSQTGHTETMKNGDRFIVLENGRRYDGVPGQPNFKIMEFERYGVKIQSKQIVSQPTTTGTSTPDLLRNPTNQNLAEFAWRAGLPLIAINLMILAIPLAYQNPRRGRTVNLVMAVLIYLTYSNLLNVVQSQMERGKIAFGLGLIGLHVIVAGIVALLFWLRVRNRPLFSRAAAGRSQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WE9</accession>
    <name>Q63WE9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL0938A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107567.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0938A"/>
    <dbReference type="EnsemblBacteria" id="CAH34934">
        <property type="protein sequence ID" value="CAH34934"/>
        <property type="gene ID" value="BPSL0938A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0938A"/>
    <dbReference type="OMA" id="AYCENLG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="17557" checksum="FBFD5DEEDBFDA02D" modified="2004-10-25" version="1">MCGMRGAADGRKAAMMGGGRWRARHGARARVCLVPGGARANGRLALPTFTKRKSSGSGMRGRRSRRGRPIRCRPIPAARASVSVRFERIEPGTRVYWYFAYVGRRVIVIFMTMRRSRTFAYCENLGRPGRRFRWKETVGVASGVRYASSHGGTETCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WW9</accession>
    <name>Q63WW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107397.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0772"/>
    <dbReference type="EnsemblBacteria" id="CAH34764">
        <property type="protein sequence ID" value="CAH34764"/>
        <property type="gene ID" value="BPSL0772"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0772"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.828"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="628" mass="71295" checksum="68C155451E3E2098" modified="2004-10-25" version="1">MKNAMAKHPYMQQPKDRGSWEFRVVIPEYLRTKDSGREFKRTLGPTYEEALTRYPGIALEWATLRAELETQADAPDRPHRPHPVITYKVLTSREHTLLDHLVASWEYRSLDAYDWEAAALSNEELDAHLDAHEADLKQRQQGLQRALRRNAPPDWFVEEIEEHLAVSLGIRLHRDCADRQDFFLRMAGAELKALRLSLERLNPDENGDGYHATPPKPAGPFDDEPDTSANERTLFKAFDIWSKQRTRAGGDKTEKEYRAFAERFAQYALDAPLERASLAALAALARERQIGRRWLEHVAAEQGVQRKTLKKYRSAMFTLFATAIDNGLTDVNPFAFRLASLQLRGTHAEERRSDKEARSPLPSPLMDRYFAGPLFAGPGFDRRLPAPVAFWYPLLLRFTGVRPLEASYLMRDDIVLPEDFTAQEHQLAGHGSASWIYIFSTHEGVDGVERPTKTGVSLRRIPVPEILMNLGFPDFVRSVPRGQWLFPMQVSRENSVNRARYALNALGDYLRTTLAEPNPLFVTYSFRHTVVDEAREAGVTQEVRDALVGHAEGDNRSKNAGETVYGARWYPASPLLEAAAKLGAAHRLPKGFPTWAEFQQRTPDFSRVVRAPKALPPKRARRAAPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X59</accession>
    <name>Q63X59_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7 8">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="7 8">DHBP synthase</shortName>
            <ecNumber evidence="3 7 8">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ribB</name>
        <name evidence="9" type="ordered locus">BPSL0678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7 8">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7 8">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7 8">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197292.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107307.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0678"/>
    <dbReference type="EnsemblBacteria" id="CAH34671">
        <property type="protein sequence ID" value="CAH34671"/>
        <property type="gene ID" value="BPSL0678"/>
    </dbReference>
    <dbReference type="GeneID" id="56596627"/>
    <dbReference type="KEGG" id="bps:BPSL0678"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.739"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="7">
        <location>
            <begin position="164"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="25319" checksum="3D27BAB9BE3CB084" modified="2004-10-25" version="1">MSFPLPSKSAPADAFSDFPLLDAEPVPPRIAAALAALREGRAVVLQDDHDRENEADLIVAAERLTDETMALLIRECSGIVCLCLTDEKVRALELPPMAQLNESKNGTAFTVSIEARAGVTTGVSAADRVTTIRAAIADNASPHDIVRPGHVFPLRAAPGGVLARRGHTEGTVDLAILAGLKPAGVLCELMNPDGTMARGADVERFAAQHGLPMLTIAELVAFRERLASLRARDACCADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XH2</accession>
    <name>Q63XH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107193.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0567"/>
    <dbReference type="EnsemblBacteria" id="CAH34557">
        <property type="protein sequence ID" value="CAH34557"/>
        <property type="gene ID" value="BPSL0567"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0567"/>
    <dbReference type="eggNOG" id="ENOG5032UZP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SELMEYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="16943" checksum="05EBE5BD7755ABB6" modified="2004-10-25" version="1">MFRMLLIAERVSGIEVEKARILDFYLVFPGMVKKIRLPDTLKVLRAHAKGAGNVYRDPVSSTSTFMEMRHIQEAALKSIAASGLIDLERFSAGYVVRSQAPVPPSLAAKLDEFVAANSPMAESILNGLSQIPLLGSNGLKHRSELMEYRYDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XI3</accession>
    <name>Q63XI3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107182.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0557"/>
    <dbReference type="EnsemblBacteria" id="CAH34546">
        <property type="protein sequence ID" value="CAH34546"/>
        <property type="gene ID" value="BPSL0557"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0557"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="117" mass="12563" checksum="7C1657CF8BF401AE" modified="2004-10-25" version="1">MTLLEHFSGPAVENEVDQAGLIKLCESGFEREFFGMLVERGLSRHPAGEERRYRLDLVVEGANDARLASSAMATPSTAPTGGPVTCPVSEFLSAQAGPSGDASRRRGVCARRKSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XQ8</accession>
    <name>Q63XQ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537830.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107107.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0482"/>
    <dbReference type="EnsemblBacteria" id="CAH34471">
        <property type="protein sequence ID" value="CAH34471"/>
        <property type="gene ID" value="BPSL0482"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0482"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1173"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TLFDACC"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="383" mass="40528" checksum="C7D7018AE725F16D" modified="2004-10-25" version="1">MGLATELLNRPATRYRGTDIDGAILEPEGLWVRGRNLNDLIGTVSFEDALWHLWFERMPTPAEGAALRARLAQYGAHFARGNPSTRAAAAVAQTGVDMVFAAATGLLRDLERPPFDAGEAPGWGADFDTLLGCLAGAPYLMRAALGAPRVDDPGTSHAARVLRAAGASGGGSPHAERVIDALLVAWHGGFGYVTPTVLVPRCAIGTGVSLSQAIAAGFMSSGPNHVGAARSAMQWLRALARRLDDEPDALDAVVRRAIGRVLDESGALLAGFGHPLFEADPRPPRIRALFAEWGFGGRHVDMFDVACDEARKRKNLKPNIDFATGAALLDLGFAEPQWGIGVGLSARIAAMAAHAVERRRRPAFGANSATARRMLAAVPVGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XV3</accession>
    <name>Q63XV3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GSH synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <shortName evidence="10">GSHase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gshB</name>
        <name evidence="13" type="ordered locus">BPSL0437</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198015.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107062.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0437"/>
    <dbReference type="EnsemblBacteria" id="CAH34425">
        <property type="protein sequence ID" value="CAH34425"/>
        <property type="gene ID" value="BPSL0437"/>
    </dbReference>
    <dbReference type="GeneID" id="56594466"/>
    <dbReference type="KEGG" id="bps:BPSL0437"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1222"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WMRKDPP"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00162">
        <property type="entry name" value="GSH_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006284">
        <property type="entry name" value="Glut_synth_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004218">
        <property type="entry name" value="GSHS_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004215">
        <property type="entry name" value="GSHS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF4">
        <property type="entry name" value="PTHR21621:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02955">
        <property type="entry name" value="GSH-S_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02951">
        <property type="entry name" value="GSH-S_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01380">
        <property type="entry name" value="glut_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="129"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="318" mass="34680" checksum="C4417159B23CF454" modified="2004-10-25" version="1">MDILFIADPLDRFKIYKDSTYAMMAEAARRGHAVYACEPNQLAWTGAGVEADVRRVTIAGDTADLHRDRWYEAAARESRALPSFGAILMRKDPPFDMEYVTSTWLLELAERAGARVFNKPQTIRDHSEKLAIGEFAQFVAPSLVTRDAARLRAFHAEHGDVILKPLDGMGGMGVFRVKADGMNLGSIIEMLSHDGARSVMVQKFIPEIKAGDKRILLIDGEPVPYSLARIPQGSEVRGNLAAGGVGVAQPLTERDREIAAALGPVLAARGLLLVGLDVIGDWLTEVNVTSPTCFREIMEQTGFDVAGMFVDALERAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YB5</accession>
    <name>Q63YB5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197255.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106900.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0273"/>
    <dbReference type="EnsemblBacteria" id="CAH34261">
        <property type="protein sequence ID" value="CAH34261"/>
        <property type="gene ID" value="BPSL0273"/>
    </dbReference>
    <dbReference type="GeneID" id="56527484"/>
    <dbReference type="KEGG" id="bps:BPSL0273"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1432"/>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GLQNHQT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="8">
        <location>
            <begin position="177"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="335"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="413" mass="42492" checksum="C7F173B0DDF46416" modified="2004-10-25" version="1">MGYQQGLSGLAGASSDLDVIGNNIANANTVGFKGSTAQFSDMYANSVASAVNNPIGIGTMLASVQQQFSQGTITSSTSSLNVAINGNGFFQMSNNGVTTYSRDGTFQRDKNGYIVNSQGLNLMGYAANANGVINTAATVPLQAPTTNIAPTATTKITGQFNLNSQDAVPATTPFNYTDPTSYNYTTSVQVFDTLGGSQNVNLYFVKSATSGQWEAYAGPAGKTPTDLGSVKFSTAGTITGTSTPAGVPTTNVGQFSFSIPTTTGAANPQNLTLDLTGTTQYGGKNGINNLAQDGFASGVLTTFSIGADGKVTGNYSNGQTSTLGQIVLANFNNPNGLVNVGNNQYVESAASGVPQISAPGSTNHGTLQGSALENSNVDLTSQLVKLITAQRNYQANAQTIKTQQTVDQTLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK0</accession>
    <name>Q63YK0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gatC</name>
        <name evidence="2" type="ordered locus">BPSL0187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106815.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0187"/>
    <dbReference type="EnsemblBacteria" id="CAH34174">
        <property type="protein sequence ID" value="CAH34174"/>
        <property type="gene ID" value="BPSL0187"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0187"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.197"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDINRER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="10845" checksum="5648905674AE6096" modified="2004-10-25" version="1">MTLTDVTRIAHLARLEMADADAERTLTQLNEFFGLVEQMQAVDTTGIAPLAHPIEQILEVAQRLREDAVTEHVNRDDNQRPAPAVQDGLYLVPKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM6</accession>
    <name>Q63YM6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106789.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0161"/>
    <dbReference type="EnsemblBacteria" id="CAH34148">
        <property type="protein sequence ID" value="CAH34148"/>
        <property type="gene ID" value="BPSL0161"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0161"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.171"/>
    <dbReference type="eggNOG" id="ENOG5033HD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPRVTPC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267285" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="91" mass="9528" checksum="5385274AD9880A73" modified="2004-10-25" version="1">MKTPPCALGLLALCLTMLCACTQAPPSTAPTISLNECAAVTPCTMPAMAPRTNGELSDALHVARAAWARCASEVDMIATCQARVRRTDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM9</accession>
    <name>Q63YM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106786.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0158"/>
    <dbReference type="EnsemblBacteria" id="CAH34145">
        <property type="protein sequence ID" value="CAH34145"/>
        <property type="gene ID" value="BPSL0158"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0158"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="48" mass="5491" checksum="7DA7061CCD07BCF2" modified="2004-10-25" version="1">MLIINIYLIAHPRASFIDLMREVSIGGSPFKVTAIDFRLMNDEAFLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YN1</accession>
    <name>Q63YN1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941342.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106784.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0156"/>
    <dbReference type="EnsemblBacteria" id="CAH34143">
        <property type="protein sequence ID" value="CAH34143"/>
        <property type="gene ID" value="BPSL0156"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0156"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1565"/>
    <dbReference type="eggNOG" id="COG4540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTHKLIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013046">
        <property type="entry name" value="GpV/Gp45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040629">
        <property type="entry name" value="Phage_spike"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18715">
        <property type="entry name" value="Phage_spike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01644">
        <property type="entry name" value="phage_P2_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_spike" evidence="2">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="226" mass="23582" checksum="5C5B782DA2EF36F5" modified="2004-10-25" version="1">MDANEIQRQARNAVRKGSILDVDHKAALCRVAIGESDDDGLQTNWIPWLTPSAGATREWLPPTKGEQVVVLGAMGDLAQGVALRGVFSDAFPAPDNLPNTHTRVYADGARVSYDHDAHALTAELPAGATVRLIAPVSVTVETESATVKAASVTFDAEQTTCTGALLVKGPLVFKSGMTGSGSAGGGHVMRIDGAADFTGEVRSMGKSLPFHTHQARGESAEVSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YP2</accession>
    <name>Q63YP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204753.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106773.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0145"/>
    <dbReference type="EnsemblBacteria" id="CAH34132">
        <property type="protein sequence ID" value="CAH34132"/>
        <property type="gene ID" value="BPSL0145"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0145"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1576"/>
    <dbReference type="eggNOG" id="COG3499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WASNDRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009734">
        <property type="entry name" value="Myoviridae_GpU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016912">
        <property type="entry name" value="Phage_P2_GpU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06995">
        <property type="entry name" value="Phage_P2_GpU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029208">
        <property type="entry name" value="Phage_tail_GPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="141" mass="15786" checksum="EBA7621C7BBBD805" modified="2004-10-25" version="1">MLMSLDQFVFSLTSAPFRELQRRRTWKHPTSSRVGARDGRQFAGVGDDTITLNGLVAPETFGSIASIRELAAMADTGEAYVLVDGAGNVYGAYVIAELNETQSYHTADGTPRRIEFQLTIERVDDDVLRMTREKNTRKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YQ6</accession>
    <name>Q63YQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106759.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0131"/>
    <dbReference type="EnsemblBacteria" id="CAH34118">
        <property type="protein sequence ID" value="CAH34118"/>
        <property type="gene ID" value="BPSL0131"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0131"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.146"/>
    <dbReference type="eggNOG" id="ENOG502ZYZE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGHPEKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="122" mass="13201" checksum="E0D6C433C28649E3" modified="2004-10-25" version="1">MVSMTAASIRYELMTTAGLRTVSGDHVVIPNDAGATFGIHMERHAPHGHPEKWTVTHLASGMAAGVGPTRDAAIAHAAANLERNKRRLRDMLDEAMTARANLQIAVHRIQQNEHAILGRIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H7C759</accession>
    <name>H7C759_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">wzt</name>
        <name evidence="10" type="ordered locus">BPSL2681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534035.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109277.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2681"/>
    <dbReference type="EnsemblBacteria" id="CAH36689">
        <property type="protein sequence ID" value="CAH36689"/>
        <property type="gene ID" value="BPSL2681"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2681"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2661"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DAYFQHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="33"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="50814" checksum="352520DC0B91C745" modified="2012-04-18" version="1">MSSELPAISVQDVSKRFRVFAKPADRLKAAVRHRIGGLAKLVPARLLGTEGASEFHALQHVSFHVQKGETIGIIGRNGSGKSTLLQIICGTLTPSGGRVAINGRVAALLELGAGFNPEFTGRENVYMNAALLGLSKAQIEERLDAIFAFADIGGFVDQPVKTYSSGMYVRLAFAVIAHVDADVLVIDEALAVGDAFFTQKCMRFLRAFMERGTVLFVSHDTNAVVNLCTRVVWLDKGRVREIGPAKDVCDSYLEAFYEEQHRASGRNVRALERSSVVRAIAEGDMRDQRALLINASKLRNDVELFQFTADAKNFGLGGASIEHVGIEDGTGAPLNWVVGGEIVCIRIAVKALQNLERAIVGFIVRDRLGQNLFGDNTYLTTLNEPFAVAAGESFSVRFGFRMPVLPVGDYSVTVAVADGSQSDHVIHQWLHDAVLLKSHSTSVSTGLIGIPMHEIVLERDTLNEVGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HX9</accession>
    <name>Q63HX9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547986.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112293.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2290"/>
    <dbReference type="EnsemblBacteria" id="CAH39776">
        <property type="protein sequence ID" value="CAH39776"/>
        <property type="gene ID" value="BPSS2290"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2290"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5911"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFGGWKI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="505"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="601" mass="64250" checksum="1947C018804C9DF1" modified="2004-10-25" version="1">MHATDQHSALNAAPSAYVYPLLVGQLLTHARGADAGRQIVYRGDVRHSYAQFRERIGRLAGALAALGVGADATVAVMDWDSHRYLESYFAIPMMGATLFTVNVRLSPRQIAHTLRDARASVVVAHADFLPLLEQVRDALGDSTCVIVACDGGAMPATSLPLAGEYERLVAAADPDYPFADFDENARAVLFYTTGTTGDPKGVCYSHRQIVLHALATAAALGAARDGQRLHRDDVYMPITPMFHVMAWGMPYIAVMLGLKIVLPGRYRAHALLDLRQAERVTFSHCVPAVLQMLLDEARLRACDLSGWKMIVGGSALPASLCRAARARHIDVFAGYGMSETGPVVALAQLRGTEGGVDVHADEDAGIDADVGAGIDVDTDVDADINANAGANASDSSVTTAAAHADDETAKRCAAGWPPPLVELRVVDAAMRDVPRDGRTPGEIVLRGPALALGYRGNPQASAALWAGGYLHTQDVAVMHGDGAIRIVDRIKDVIKTGGEWVSSLELEGLLNDIAGIRESAVVGVPDARWGERPAAVVVCERDAPLAAQDVRARLLEHVAANRISRYAVPECERIVFVDALPKTSVGKIDKKSLRRLVERID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I02</accession>
    <name>Q63I02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187603.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112270.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2267"/>
    <dbReference type="EnsemblBacteria" id="CAH39753">
        <property type="protein sequence ID" value="CAH39753"/>
        <property type="gene ID" value="BPSS2267"/>
    </dbReference>
    <dbReference type="GeneID" id="56598376"/>
    <dbReference type="KEGG" id="bps:BPSS2267"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5874"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALNWPVR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="417" mass="43075" checksum="9F21D25843521699" modified="2004-10-25" version="1">MFAPETHRRDGSPRFFNPMMIAVVAGALVMSAAMGVRQTFGLFIGPFSFDHGLPVTTIAFAIALHNLVWGAAQPFAGAAADRYGAGPLVAIGAVVFALGLAIAAVVPTGPMLVLGIGVLVGIGISCTSFGVVLTAVGRGAPAEKRSMAMGIASAGGSLGQVALVPIAQWFTSHSGTMVSLFVLAGCMIAIAPLGVLLDKNTRGSHVVAHETATISLKETLSYAVRHRGYCLLTLGFFTCGFQLAFIGTHLPNYLLLCHMPAGLGATALALIGLFNMAGSWACGWLGGRYRQQHVLGWLYLIRGAAIALFFLGPKSNASVVVFAAIMGLTWLGTVPLTSGLVAKVFGTRHLGTLFGVCFLSHQVGSFLGSWLGGYVFDATGSYSLIWGATALAGLFAALLHFPINDAPAHGGAAVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I84</accession>
    <name>Q63I84_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pilus subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112188.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2186"/>
    <dbReference type="EnsemblBacteria" id="CAH39671">
        <property type="protein sequence ID" value="CAH39671"/>
        <property type="gene ID" value="BPSS2186"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2186"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5769"/>
    <dbReference type="OMA" id="MYELIAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007047">
        <property type="entry name" value="Flp_Fap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04964">
        <property type="entry name" value="Flp_Fap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="72" mass="7746" checksum="AA316D5C53116BA0" modified="2004-10-25" version="1">MRTQSFSRKSPRAHGIGARPARAFMRWLRDESAVSAIEYALIASLIAIVIIGAVQVVGTNLQSVFSTVASDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE3</accession>
    <name>Q63IE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyl-CoA synthetase</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552209.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112129.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2130"/>
    <dbReference type="EnsemblBacteria" id="CAH39611">
        <property type="protein sequence ID" value="CAH39611"/>
        <property type="gene ID" value="BPSS2130"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2130"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5688"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VARMTQI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="630"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="787" mass="83278" checksum="DB9122317656612F" modified="2004-10-25" version="1">MTVRNLDALFHPTAVAVVGASPRPGSVGAMVWACVLDGRFGGAIWPVNPKYGELNGHKVYPYVDQLPSAPSVALICTPPATWPGIVRKLGGLGVRAAIIVGETRSGADRAALERALAAAKPYLLRVVGPGSLGVVSPALGAHFGAPACIVKAGGVAWVSQSNALTNAVLGWAHARGLGFSHAVALGGEADVDAADVLDYLASDAETRAILLELDTVKSARKFMSAARAAARNKPVLALRAGRGDSGDLLYTAAFQRAGMVRVDALDDLLDEIEALGVGRAAATSGGVTLVTSDRGVAKLAVDALAAAGETLAQWPRAAVDEVGGALPAGIVAGNPLLLGDDARPEYFGAALKALAQHPPTGTVFVVHATSHSAPAVDVARVLIESRKFARRGMLACFFGGVDAATRDALHVHGIPVHTTPQRLARAHARLVDYQLGRELLMQTPEGTPPQPAASISAARHTARAALAQGRDGFEGDAALEWLAGFGIERATDADVDMGDTIVDITVGMYDDPNFGPVFRYSVPPADGVSAPFVVYGLPPFNTVLARAVVARSPYAHRAPPEPLLQALTALSQAVCDVREIVEMSLVLRVRPTRVVALGPHIRLATGRSRLAIVPYPRYLEQQLDWRGERITVRPIRPEDEAAHRELLSAMTPDDLRMRFFGAIRNFDHSQIARMTQIDYDREMALIATLDDADGRAHTLGAVRAVTDPDNEATEFAIAVRPDQKGKGLGRMLMTRIIDYARSRGTAWMIGEALRENTAMISLAKDSGFAVSSTEEPGVVAFRLKLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE7</accession>
    <name>Q63IE7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ureidoglycolatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Ureidoglycolate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529347.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112125.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2126"/>
    <dbReference type="EnsemblBacteria" id="CAH39607">
        <property type="protein sequence ID" value="CAH39607"/>
        <property type="gene ID" value="BPSS2126"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2126"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5678"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YVSQCMS"/>
    <dbReference type="UniPathway" id="UPA00394"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="72"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="29861" checksum="2E4D12F9E441A3BE" modified="2004-10-25" version="1">MKLLRYGPVGQEKPGLLDADGRIRDLSSLIDDVADGALSDASLARLAAADPASLPLVAGEPRIGACVGRIGKFVCIGLNYADHAAEAGLAVPAEPVVFGKWTSAVSGPHDGIEIPRGSVKTDWEVELGVVIGRACKNVDEADALSHVAGYCVVNDVSEREWQIERGGQWDKGKGFDTFGPIGPWLVTRDEIADPQALDLWLDVDGRRYQSGNTRTMVFTVARLIAYLSRCMSLQPGDVISTGTPPGVGMGVKPSPVYLKPGQTVRCGVAGLGEQQQRTRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IK3</accession>
    <name>Q63IK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205727.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112069.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2066"/>
    <dbReference type="EnsemblBacteria" id="CAH39546">
        <property type="protein sequence ID" value="CAH39546"/>
        <property type="gene ID" value="BPSS2066"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2066"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5611"/>
    <dbReference type="eggNOG" id="COG3970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDVQAIK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="394" mass="42542" checksum="73790A5C5482BE66" modified="2004-10-25" version="1">MNALPPSECLPHDAEYALLIGRVWRGGDHAGPSVVVVRNGQVFDITAITPTVADLLDRPDVTAIVGSSAGEPIGDIEPILLQSQASHQSVQPLPDTLLAPCDTQAVKACGVTFAVSLLERLIEEQAGGDPVKAHEIRAHFTTFLGKNFSHIRPGSDAAARLKQDLLERGSWSQYMEVGLGPDAEVFTKSQPMSSVGFGAAVGLSPASQWNNPEPEIVLAVNSRGVPMGATLGNDVNLRDIEGRSALLLGKAKDNNGSCAIGPFIRLFDDRFTMDTLRHASVSLQIEGERDGFLLSGVSNMAEISRDPLDLVSQVYGDHHQYPDGFMLFLGTMFSPTQDRHVKGEGFTHELGDRVLISTPSLGTLINTVQLSTQIPRWEFGVRALFRSLFARNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX6</accession>
    <name>Q63IX6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552098.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111946.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1940"/>
    <dbReference type="EnsemblBacteria" id="CAH39418">
        <property type="protein sequence ID" value="CAH39418"/>
        <property type="gene ID" value="BPSS1940"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1940"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5427"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HIRIETV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="221"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="465"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="611" mass="66341" checksum="619D90CC48FF703B" modified="2004-10-25" version="1">MHVEVFAQHSSCPGWHGEMARRIRAFDWSATELGPLERWPASLVAAVRTVLASPVPLVMLWGASGYMLYNDAYAAFAGGRHPYLLGQPVELGWPEVADFNRNVMRTCLAGGALSYRDKALVLLRNGRPEEVWMDLYYSPLAGDDGAPAGVLAVVVETTERVLAARHRDRAKAALHETNAELRRLTETLEQRVADAITERASIEEQLRQAQKMEAIGSLTGGIAHDFNNVLQVVSSNLQMLSAELGEDARAQRRIASAANAVARGAQLASHLLAFARRQPLAPAVLEPRGLIDGMREMLHRALGESVHVDADLRDDVWNVLADRHQFENALLNLAINARDAMRGEGTLKITACNIVLEAGRHARRNGLPPGEYVAFDIADNGVGMTPDILERVFEPFFTTKPDGQGTGLGLSMVFGFVKQSGGHTSIESAPGRGTTVRLLLPRCREAPAGEPAAQRRLPAEGGRETILVVEDDADVRLAVVDMLAQLGYKVITASDGEAGLLALESGAPIDLLFTDVIMPGRIKGGELARRAAQRVPPVPVLFTSGYTRDEIFHAGRLDPGVMLLGKPYRRDELAHKVRSVLDAHASARRARGARHAQADPRAKTAAARVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J36</accession>
    <name>Q63J36_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Na+/H+ antiporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200601.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111886.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1880"/>
    <dbReference type="EnsemblBacteria" id="CAH39358">
        <property type="protein sequence ID" value="CAH39358"/>
        <property type="gene ID" value="BPSS1880"/>
    </dbReference>
    <dbReference type="GeneID" id="56598291"/>
    <dbReference type="KEGG" id="bps:BPSS1880"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5346"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETVVMWW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="10"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="526" mass="56125" checksum="5B264F573A509F75" modified="2004-10-25" version="1">MSPVSAFKLVLLSFLAIVALELLAKRLRLPPAAALLVGGAGIAFLPGLPPVNLDPDLVLIVFLPPLLMDGAYFSVWEEFKRNVGGIMMLAIGAVAFTTLAVGVAVHLVAPGLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAGLVLFRFAVAAALTGAFSTGDAVVRFAQLGVGGVAVGFIVGWLIVRFLKLVEDDYLVITVAVLAAWISYIAGELFEVSGVIATVTTGMMLGWHQHEVFSASVRNRGTAFWQVIVFLLEALVFVLIGLSLRGVIERLGGLGEVFATMTPAVAAVVAAVVASRFVWVFAVELLKAPVARLRGRGPRGDWKAATVMGWAGMRGVVTLAIALSLPDAMPGRDLILVAAFAVILVTVLLQGTTIGPLIRLLKLRDPGPAAHHLTEPQTWARVEAAQLSAIQPLVHDAEGNVIHPRLLEQYTYRASVTARHQDEPAFPQRERDAHYDVVLAAIAAGRAELLRLHRGGQIHDEMLYLLERDLDLQEIAAQHAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J91</accession>
    <name>Q63J91_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540305.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111831.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1827"/>
    <dbReference type="EnsemblBacteria" id="CAH39303">
        <property type="protein sequence ID" value="CAH39303"/>
        <property type="gene ID" value="BPSS1827"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1827"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5274"/>
    <dbReference type="eggNOG" id="ENOG502Z8P8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VLIGFHI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="491" mass="53637" checksum="B734EA3C7A21D809" modified="2004-10-25" version="1">MSATTLPVPAAGGRARRRKLLSDPKHWAAQAGLWSVTALLIAAHQGTLLTYGFPCLAIATGLWLYFMSPARYVGFMWWMWFLSPEVRRLADWSKGAYTPTSLIQIAPLAVTMIAGLGLLRHYRVLAERRGLPVLLILFGLMYAFLVGVVSSGPLAATYDLANWLYPVLIGFHIAVHARDYPEYRKVILSTFVWGMLVMGVYGMVQFFVMPKWDALWMIGSQMNSQGDPVPYGVRVFSTMNSSGPFAFAMMGALVFMIAATERVRWLAGAAGFISFCLCLVRSTWGGWVVALAIQLAKSSNRVRVRIIGSAIVLAGLCVPLLSVGPVADRLGQRLQSITNLKDDRSYDDRNKFYATFAQTAFTDVAGEGLGATGASTKLSSDSGSLGKYGSFDSGVMNVPFVLGWPGTLLYLLGLVWLLGRALRASLRLRRDKFVAACLSLSLSVFAMLVFTNSFIGTGGLLLFMSIFSILSAAHWQKLQRASVARFPGADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JG4</accession>
    <name>Q63JG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport-related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530326.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111758.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1752"/>
    <dbReference type="EnsemblBacteria" id="CAH39227">
        <property type="protein sequence ID" value="CAH39227"/>
        <property type="gene ID" value="BPSS1752"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1752"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5179"/>
    <dbReference type="eggNOG" id="COG1457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASWQIAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="474" mass="50754" checksum="545A3D66DA0F072A" modified="2004-10-25" version="1">MPNATDAQRRALRERRTIDYIPDHERHGKLSSQFTLWLGANLQVTAIVTGALAVVLGGDVSWSLVGLALGQLLGAAVMALHGAQGPQLGLPQMISSRVQFGIYGAVIPLVLVCLMYVGFSASGTVLAGQALAQLFGVADPVGIFAFIAVVVVLAVFGYRTIHALGRVSSIVGVVAFVYMFVRLLAGHDVGALLAIRHFSLSSFLLAISLSASWQIAYGPYVADYSRYLPRSTSARRTFWAIGLGSVLGAQASMAFGVFAAALAGKQFAGHEVQFIVSLGASGATAALLYFAIAFGKLTITTLNAYGSVMSVATIVTGFSGRAQITQRARMAYVLAMVAAVAWLALVGRHAFLKDFSAFILFLLAFFTPWSAINLVDFYWVTRERYDVPALYDPDGRYGRWNVAGVSIYAIGVLVQMPFIATEFYTGPLVAKLGGTDISWIIGLVVPGVLYYVTARRQTAHVPERLILPDEPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JS6</accession>
    <name>Q63JS6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188105.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111646.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1638"/>
    <dbReference type="EnsemblBacteria" id="CAH39113">
        <property type="protein sequence ID" value="CAH39113"/>
        <property type="gene ID" value="BPSS1638"/>
    </dbReference>
    <dbReference type="GeneID" id="56597990"/>
    <dbReference type="KEGG" id="bps:BPSS1638"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5030"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYEHRPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="19674" checksum="C381EEE93DB08E3D" modified="2004-10-25" version="1">MSTTISAYRQIGDKRFREISGLYFEDFEPGNVYEHRPGRTITDVDNIWMTLLTMNTQQVHFDAEYAAKTEWKKLLVDSTFTLALLTGMSVRTVSAKVVANLGWDKVRASAPVFAGDTLYAESTVLSRRESKSRPTQGIVTVETKGVNQHGVIVMSFERTMLIYKRGHSPEAGANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K47</accession>
    <name>Q63K47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009934668.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111525.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1519"/>
    <dbReference type="EnsemblBacteria" id="CAH38992">
        <property type="protein sequence ID" value="CAH38992"/>
        <property type="gene ID" value="BPSS1519"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1519"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIVERTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="22373" checksum="950531A1AE092F77" modified="2004-10-25" version="1">MKPSRHRAHTACRCPPPCGTGPYGRQFRRRSSRACAATEANGTPIAAILTGANRNDVTQRIPVIEAIEPINGVRGRPLSRPKRVYADRGYGRDEYRRIRHARGIPPSIARRGEPRGSGSGKIQWIVERTHAGMHRILRLRYTIRTSRRHSRGISQTRVRLDLREQLAANSAAVTEPSPRRAASYRTSRRSRGETAAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K72</accession>
    <name>Q63K72_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ImpA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111500.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K72"/>
    <dbReference type="STRING" id="272560.BPSS1493"/>
    <dbReference type="EnsemblBacteria" id="CAH38966">
        <property type="protein sequence ID" value="CAH38966"/>
        <property type="gene ID" value="BPSS1493"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1493"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5747"/>
    <dbReference type="eggNOG" id="COG3515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFAQADW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010657">
        <property type="entry name" value="ImpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017739">
        <property type="entry name" value="T6SS-assoc_VCA0119"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06812">
        <property type="entry name" value="ImpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16989">
        <property type="entry name" value="T6SS_VasJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03362">
        <property type="entry name" value="VI_chp_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ImpA_N" evidence="2">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="648" mass="67315" checksum="C983865442A2946E" modified="2004-10-25" version="1">MSERRPPGGAAARARMPIDVEALAVLGRTDIDSAMPAGADVRADARFDALHAELAKLASPGASGQVDWRAATHLAAELLRERGKDLLVGCYLAGALLQTGGAAGLRCGLEIVGDLVERHWDAMSPPVSRMRARRGALQWLVDRVDAMHDAGAAACGGACSAELVAQLRAAARRIDALLAERDDDAPTMRAVHAFAERLPVEVVEVVEVADEADVADVAEATEATEATEATEATEATEAADVAETAETAETAETAETAETAETAETAETAEADAHGSTGGPAAEIAIAAAEQALIDPAGRAAPSAGTDTNANADAAGQPARLDEAAGRERALADALAQLHCVATAFAQADWADARGFRLRRVACWSSVCALPETDAENGRTRIAAPSASIVGAAKSIDGDGEPVAAVRFAEAHAQAFPLWLDLQRIAARALARAGGDGADARREVETAVRALLARLPGLDALTFADGTPFADDATRAWLGELGAPVVAADAVSPSSLPLSPRPSPPERSSPMAGEPARAPGDACGASADDAVDRACAFAASGQLDLALHAIQHAIDRATSAEQRLRARVRLCELARDHWPHEVPEAFARGVIEPIRRHDLLAWNPELALDGLSAAYALLIRRDRESAHARTVLDEIASVDAARAMRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KN1</accession>
    <name>Q63KN1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551782.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111340.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1330"/>
    <dbReference type="EnsemblBacteria" id="CAH38801">
        <property type="protein sequence ID" value="CAH38801"/>
        <property type="gene ID" value="BPSS1330"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1330"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4627"/>
    <dbReference type="eggNOG" id="COG3618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HIIDPRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="32602" checksum="87CD7AC980FAA972" modified="2004-10-25" version="1">MSEQEWNAFAPAAAPHAACGITTIDAHAHVFETGLPLAGRRRYAPDYDAPLDAYLAQLDAHRVSHGVLVQPSFLGSDCRYLLRALARQPRRLRGVAVIDAGCAPAALDALDRAGVVGIRLNLIGMPDPALDGPAWRATLERVAALRWHVELHAQAQRLERLIAPLLAHRVNIVVDHFGRPEPARGIADAGFRDLLRAAATRRVWVKLSGAYRNWPFAPGEAHARARAAFDALAAEFGAERLVWGSDWPHTQFERTETFGRALAFARRWIPDDAMRRAIFVETPARLFRFGEQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KN5</accession>
    <name>Q63KN5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111336.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1326"/>
    <dbReference type="EnsemblBacteria" id="CAH38797">
        <property type="protein sequence ID" value="CAH38797"/>
        <property type="gene ID" value="BPSS1326"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1326"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4623"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETRNGGN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="197"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="483" mass="52095" checksum="8FFD4EA84D3FE0C6" modified="2004-10-25" version="1">MALPQDSVNMALFCDFENIALGVRDTKFEKFDIKPVLEKLLLKGSIVVKKAYCDWDRYKTFKAAMHEASFELIEIPHVRQSGKNSADIRLVVDALDLCYTKAHVDTFVIISGDSDFSPLVSKLRENAKRVIGVGVKNSTSDLLVANCDEFIFYDDLAREQQRALAKRDARKAEAGAKRTADDDKHRKHDGDARKAEAISLAVETFDALASERGESGKIWASVLKSAIKRRKPDFNESYYGFRAFGNLLEEAQARGLLEIGRDDKSGTFVFRPIQTAAVEVMRPIEAAVDDASAGAKPSGKKAHGKARSAKKRMPEQMPLIVETAAGAEGHAHADIEANAELAEASDSAPRGMRRERPADDARDTHPAHGAHEPHETRAAHEPARAGESAKVAEAAEAQAADTAKPARSRARKTAVKKAKGTQARAASASPVAAAEADAAGEPSHAAPHAFAPESAAEAAPAKTPRKSAPRARRPRKTAATSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L17</accession>
    <name>Q63L17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative peptide synthase/polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111204.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1194"/>
    <dbReference type="ESTHER" id="burps-q63l17">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38661">
        <property type="protein sequence ID" value="CAH38661"/>
        <property type="gene ID" value="BPSS1194"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1194"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5362"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VADPGHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="526"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="893" mass="95238" checksum="B104BFA38EBE2931" modified="2004-10-25" version="1">MPPAPPRAPDRLPVQEAPPRLTAPARERPVRALPARAAGGGRRGANACRDASAARPGARDGDAPRDAGGRRSPTNTAELPAARRRYMLEDSGARIVLTLPDAADDLPRDLALVCVYPGEADVDVNIDARTAASGPTARVTADAPADAGADATTGACPDAWPAPDPTQAAYVLYTSGSTGRPKGVVVTHGSLANHMAWMTRAFPLDAHDAVLQKTSAAFDASIWEFFLPLLAGARLVMAPPGLERDVPALVATLARERITVLQLVPSLLRVLVDAPGFGACDALRCVFCGGEALTADLARRFAAAHRAALVNLYGPTETTIQVCAERVDAADDPVPVGRPIDNVRLYVVDSRNRLSPVGVRGEILIGGAAPARGYLDRPALTAARFVADPIDPRAPRVYRSGDVGAWRADGRLDFFGRADDQVKLRGYRIELGEVEATLARHPDVANAAASVDLDANGIARLVCAYDCRAGRGVEPAPLRAWLATQLPDYMVPGRCRRLDALPRNASGKIDRAALARGVDAPRDGAAPRDPVELRLERVWEAVLDVQPVGVDRTFFDLGGHSLLAVRLMAEVKREFGCDLPLASLFEAPTVAAQAALIRQRERAHPVVVRVNRGIDGERPVFLVHPTGGNVLCYRDLARRLGPARPIYALQDPGLEGDAGYDSVEELAARHIAHIRPLAGDGPYYLAGWSSGGVVAFEIARQLLAQRCEVGLLALIDSVASDGAQPAPRTDAELIGSIGRLLAFAAGVDAPDLAALEPSAAMARLRELAVAAGSLPPDAPPERMRRLFDVFRRNAAAVRRYRPGPYPRRVLLLRATQPLPEPVRDAAARQRGDSPELGWERVAVVSRCDIPAHHLSIVHEPAAALVGARIRDALHAADRIEAIGERVFFTLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L54</accession>
    <name>Q63L54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">narK</name>
        <name evidence="9" type="ordered locus">BPSS1154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009971853.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111167.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1154"/>
    <dbReference type="EnsemblBacteria" id="CAH38622">
        <property type="protein sequence ID" value="CAH38622"/>
        <property type="gene ID" value="BPSS1154"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1154"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4379"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LVIHTID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="424" mass="45501" checksum="5A4E24485F96EC15" modified="2004-10-25" version="1">MGSRHGSGAFDPAPAIPARAWSVLFASTLAFLVCFVVWMMFGVLGVPLREDLHLNSTEFGLLTSTPVLTGALMRLPLGAWTDRFGGRIVMTVLLVVCSVPVYGVSYANALWQFLLIGLFLGCVGASFAVGTPYVARFFPPRRRGLAMGVFGAGTVGAAVNLFVTPLLLAAYGWRVVPRVYALALVVTAAVFWFASAPDPGAGEQKGSWVDSFKVLRDPRVWKLCQYYSITFGGFTALSLWIPQYLKNGYGMSLVAASAFAAGFSLPGSVLRALGGALADRYGAHAVTWWGLWVAWICLFLLSYPPTDLVIHTIDGTATLRLHVPLAAFVVLTFVLGAVFAFGMASTFKYVADDFPNNMGVVTGIVGLAGGLGGFLLPIIFGALVDLLRVRSTCFMFLYGIVWVSLILLYLAEIRRAPVTGAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L78</accession>
    <name>Q63L78_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004548258.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111143.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1130"/>
    <dbReference type="EnsemblBacteria" id="CAH38598">
        <property type="protein sequence ID" value="CAH38598"/>
        <property type="gene ID" value="BPSS1130"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1130"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4348"/>
    <dbReference type="eggNOG" id="ENOG502ZAMI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LSHWPAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="50920" checksum="F094A974FE458E3C" modified="2004-10-25" version="1">MTTLLALHDGDHAVQFDDDVAARLAGFELRLLAGRVVAIRENRFIDLQNLIAGDGAFTRDGDPHDLRRRNLGTLHYDFGGHGELAVRDAETDAARLAAALAGESARPPSPAAPRSRVQAVRLSPGDRLAFVPFEHARDVPNISADATHNAATRLTLSHWPANRTPARYKANLSTQSVLRFAAERADAADVRHVTTDHFDLDGLASVYGLIAPDHALRHQARLVELARFGDFARGRSDAARRLAFALDTVAARASREIGATDDESARVARLFRALLPALRDLLDAPPPEELWRDADRHHAATEALLDHPDAALEQHPALDLAVFRLPAAPALRAGAARRYFGLSPIGFHNRTPLSTLAIVAHGDVVVHQRYEGWVERVSAAPRPRRDLSILARALRAAEPHACRWQYDGVQHIMPRLGHDGAQPSGVPAETIVDELKRLLAIAPAAWTPTPDARRRGDAPSGRTASGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LD6</accession>
    <name>Q63LD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS1073A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111085.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1073A"/>
    <dbReference type="EnsemblBacteria" id="CAH38540">
        <property type="protein sequence ID" value="CAH38540"/>
        <property type="gene ID" value="BPSS1073A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1073A"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5210"/>
    <dbReference type="eggNOG" id="ENOG5033HD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267332" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="91" mass="9540" checksum="3E46284ECCC94971" modified="2004-10-25" version="1">MKTPPCAPGLLALCLTMLCACTQAPPSTVPTISLNECAAVTPCTMPAMAPRTNGELSDALHVARAAWARCASEVDMIATCQARVRRTDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LI9</accession>
    <name>Q63LI9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198480.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111032.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1026"/>
    <dbReference type="EnsemblBacteria" id="CAH38487">
        <property type="protein sequence ID" value="CAH38487"/>
        <property type="gene ID" value="BPSS1026"/>
    </dbReference>
    <dbReference type="GeneID" id="56597398"/>
    <dbReference type="KEGG" id="bps:BPSS1026"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5156"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="75" mass="7237" checksum="AC28566C544B6E5B" modified="2004-10-25" version="1">MTGKGGAAANPRAATAIVVAASGSISPASRRTALSTMKTTANATARRRDGGTMKAPKEPIASGGAVLAGSVESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LS8</accession>
    <name>Q63LS8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551607.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110943.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0934"/>
    <dbReference type="EnsemblBacteria" id="CAH38397">
        <property type="protein sequence ID" value="CAH38397"/>
        <property type="gene ID" value="BPSS0934"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0934"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7235"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHHFLAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="5">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD_C_2" evidence="6">
        <location>
            <begin position="494"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="554" mass="60821" checksum="C5666ACA2C5803C3" modified="2004-10-25" version="1">MARIIPDDWKNLAATGAAERERETLATLERTLPDAYTVYHGVHWTRADHNFSVFGEAHFVIVSPAGRVLVIEQKAGFLRETPKGLVKVYLQTERNVSIQLARTLENLHRRLTAALGAGAYGVEELLYCPDYTIRNPAIAGVAPARIVDATRRHALAARIVDALPADEPPFPSAAKVHHFLANELSLTPDTSALVGQADTLVTRLSGGLAAWARRLEFEPFRLRVIATAGAGKTQLAVQAMRGAISAGKRVLYVCFNRPLADHVARIAPQGVKIANYHQLCDWIARDGGHVPDFGARDAFAQLEARFAQTPIAECWRFDTLIVDEGQDFQPSWAHALERLVAPGGAWWWLEDPLQNLYMRERVPLSGWVTLKETTNYRSPRDILDYVRDVVGSVEPLAAELVSGSPFGGSEISISAYDDAHAQSPAQACIDATKRAITHALALGFRKQDIAVLSFRGREGSALATLDQLGPHRVKSFTGKYDLFGNPEYREGDVLLDSLHRFKGQAAPCVILTEVDFDAFDERAARKLFVGATRATMKLIVVASKRAAQRIAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LT4</accession>
    <name>Q63LT4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aliphatic sulfonates binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539083.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110937.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0928"/>
    <dbReference type="EnsemblBacteria" id="CAH38391">
        <property type="protein sequence ID" value="CAH38391"/>
        <property type="gene ID" value="BPSS0928"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0928"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7227"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDPYFAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266978" evidence="4">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="34"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="327" mass="35398" checksum="C4216E4B6F1EE3D5" modified="2004-10-25" version="1">MIRPARWFARTVTAALASLCVASAFAQDAAGDKVLRVGYQKAGLLAVVKAQGTLETRVKPLGYTVKWFEFPAGPQLLEALNADSVDIGYTGAPPAVFAQASGVRFVYVGAEPPSPHNEAIVVKADSPLRRVADLRGRKVALQKGSSANYLLLEALRQAGVRYDEIRPIYLPPADARAAFESGTVDAWVVWDPYYAAAQHALKARTLADYTGLSATYNFYEATRDFATRHPDVVGAVLQQLRETGLWVNAHSAETAALIAPKIGLDRALVETWVKRVPYGTTPLDDKIVASQQRVADAFLAAKLIPRKLTIADNVWTERRAAAALAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LT9</accession>
    <name>Q63LT9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531745.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110932.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0923"/>
    <dbReference type="ESTHER" id="burps-q63lt9">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38386">
        <property type="protein sequence ID" value="CAH38386"/>
        <property type="gene ID" value="BPSS0923"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0923"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7222"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRANFIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="317" mass="35596" checksum="F393F4B0C5D9C11C" modified="2004-10-25" version="1">MATVRDTLTVRSGDVRLAVYLSGPRNAPPVILVHGYPDSARVWERVREHLDKRFRVIAYDVRGAGASDAPRRRADYKLSVLAQDLLAVADVTCGDRPFHLVGHDWGSIQCWEAATDPAVKGRLASYTSISGPCLDHVFRAPLNLRQTLKSWYIAFFHLPLVPELVWRLGGAKLWPLWLRRTERIVADADPDQLRNGLNGLKLYRANFIERARRPRERYAQAPVQIIVPRYDRYVTPALTRGLDRWLGAHRRDEIAASHWTVIRDAALIAARIGRFAAAHEPKRHAIAAGGAKSGGQPRAKQRTNQHASAGRRLKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LU0</accession>
    <name>Q63LU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532883.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110931.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0922"/>
    <dbReference type="EnsemblBacteria" id="CAH38385">
        <property type="protein sequence ID" value="CAH38385"/>
        <property type="gene ID" value="BPSS0922"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0922"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7221"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="STAINYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="425" mass="44850" checksum="62C206CF4514FFD7" modified="2004-10-25" version="1">MMNKKPLSLTQIVLATSVGNALEWFDIAIYAFFAVHIAKNFFPTANETASMLLTFGSFGASYLVRPIGGMVLGAYADKRGRKAALMMSVGLMMIGTAIIAVIPPHASIGLLAPAGVFIARLIQGFSAGGEFGASTAMLIEHAPERRGLLASWQFATQGLATLLASTFGFALAKLMPASELSAWGWRMPFFFGLLIGPAGLYLRRFLEDAADYTEAEHTATPVRDVLTRQKALLLTSIGALTVSTAVNYLLQYVPTFAIRELHLDASTGFAASIVAGLMLTLVTPFAGHLSDKIGRVKQMSTAALLLFVTGYPAFAYVVSHVSVAALFGLVAWLALLKAVYFGALPALMSEIFPTSTRVTGISISYNIGVTVFGGFTPAIVIWLSSATGSKAAPSFYMMFTAVISLAALAAVSRGKEPLSSAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LV6</accession>
    <name>Q63LV6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547456.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110915.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0906"/>
    <dbReference type="EnsemblBacteria" id="CAH38368">
        <property type="protein sequence ID" value="CAH38368"/>
        <property type="gene ID" value="BPSS0906"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0906"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5003"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMEVASY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="323"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="404" mass="42832" checksum="EA00142B885D1888" modified="2004-10-25" version="1">MPRTVVVIGGGQAAGWVVKTLRDEGFAGRIVMIADEAHLPYERPALSKAVLAGEADIATVRVMQPDAFGALDVDAWQPERAASIDRARRVVRTASGREIEYDRLVIATGGTPRRLPDAIVGTAHLHYLRTLDEALALGEKLRASRRVLVIGGGWIGLEVAATARKLGVDALVVEGAPRLCARSVPGAVSDFLLDLHRANGVDVRLNASLASLDAHPDDARRVRATLAGGGVVDADFAVAGIGLALNTSLATEAGLHVDDGIVVDEYGATSDPAIFACGDVANHPNAWLKRRVRLESWANAQNQAIAAAKAVLGVRAPYAEIPWFWSDQYDVNLQILGDLPADARCIVRGELAAKRATLFFVADGALRGVIAINAARELKLARKWMNQGRAIDVAALADTAKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M30</accession>
    <name>Q63M30_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939863.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110841.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0830"/>
    <dbReference type="EnsemblBacteria" id="CAH38292">
        <property type="protein sequence ID" value="CAH38292"/>
        <property type="gene ID" value="BPSS0830"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0830"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7105"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VFPLFQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="247" mass="27090" checksum="F6101B37B345E452" modified="2004-10-25" version="1">MDSDIMHIGGRIRRLRRELKKTLLEVATEANLSVGFLSQVERNLTGISISSLVNVAKALRAPLSALIDQPRQDQPDSHEGSRESYAIRPTQQRYERLSTTFAGSLLNAVKVSMMEGYSSEWVAHAGDEFVFVLSGHVRYTVGKQDYPLGPGDSLHFDAHERHRVVNVGHGPVELIAVGTLPLFGDGQPTFPSLPGERKPPRTRAARKRIEPPPTPSAQQDARHDEAAAPNAVTTHDGAPRAAKKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M32</accession>
    <name>Q63M32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110839.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0828"/>
    <dbReference type="EnsemblBacteria" id="CAH38290">
        <property type="protein sequence ID" value="CAH38290"/>
        <property type="gene ID" value="BPSS0828"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0828"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4913"/>
    <dbReference type="eggNOG" id="ENOG503173K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RINAGHD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025421">
        <property type="entry name" value="DUF4148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13663">
        <property type="entry name" value="DUF4148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266984" evidence="2">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="112" mass="11805" checksum="13FD3C00D1E5F933" modified="2004-10-25" version="1">MEVHIMKTALTLKTAALALALAAPALSFAQPSSDTSITRAQVRDELIQLERAGYQPSKNQYPANLQAAEARIAPMNGGADMSGYGGTTGGAMQSGQRVSPTSGGWDTPYRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA3</accession>
    <name>Q63MA3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523873.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110768.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0757"/>
    <dbReference type="EnsemblBacteria" id="CAH38217">
        <property type="protein sequence ID" value="CAH38217"/>
        <property type="gene ID" value="BPSS0757"/>
    </dbReference>
    <dbReference type="GeneID" id="56530792"/>
    <dbReference type="KEGG" id="bps:BPSS0757"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6997"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MYQHAIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266160" evidence="4">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="5">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="384" mass="40357" checksum="37C21C3ACA0F6E23" modified="2004-10-25" version="1">MKNIRFACATAGVLAATAAHAQSSVTLYGLIDAGIMYTNNVASGNSHGGLVQATTGAVNGSRFGVRGTEDLGGGLKALFVLENGFNAENGKLGQDGRLFGRFAYVGLSDNRFGTLTIGRQYDSLVDFVAPLSATAGTFGDASFAHPFDNDNLNHSLRINNAIKYTSNTYAGLKFGGMYAMSNSTDFATNRAYSFGASYTRGPLNVAAGYLQINGSKGTTAGSPGAVDIVESAANGKGGFSLGADRMRSYGGGLNYAFGPATLGFVYTRAEYENTASFGSTGGTVRFNNYELNGKYQLTPAFSVGGAYTYTDGHVENTVKYGSDPKWHQVDLMAVYRLSVRTDVYLEGMYQHASGRNYVAMINTAGGASSTGNQVVAAVGLRTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MM2</accession>
    <name>Q63MM2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">glsA</name>
        <name evidence="6" type="ordered locus">BPSS0628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184594.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110649.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63MM2"/>
    <dbReference type="STRING" id="272560.BPSS0628"/>
    <dbReference type="EnsemblBacteria" id="CAH38085">
        <property type="protein sequence ID" value="CAH38085"/>
        <property type="gene ID" value="BPSS0628"/>
    </dbReference>
    <dbReference type="GeneID" id="56597687"/>
    <dbReference type="KEGG" id="bps:BPSS0628"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6814"/>
    <dbReference type="eggNOG" id="COG2066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RPRNPFI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="32645" checksum="ABB3FBC2436DAAE9" modified="2004-10-25" version="1">MDYQPILERIHTELAPWIGAGRVADYIPELAKVPAERFGMAVVTLDGRIHTVGDARERFSIQSISKLFACTLAFQLLGDALWERVGREPSGNAFNSLVQLESERGIPRNPFINAGALIVTDVLCRRFVGAETALVQFMRRLTGVAELDYDLRVASSELAHAERNRAMAHFMASFGNLHMPPETVIDAYCRQCAIEMNCIELATAALFLANAGVAPVSGERILDASSAKRLSALMLTCGTYDAAGDFVYRVGLPAKSGVGGGIVAVLPGEMAVCVWSPGLDANGNSVAGVQALEQLTTLTGRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MT7</accession>
    <name>Q63MT7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OpuAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110582.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0561"/>
    <dbReference type="EnsemblBacteria" id="CAH38018">
        <property type="protein sequence ID" value="CAH38018"/>
        <property type="gene ID" value="BPSS0561"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0561"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4580"/>
    <dbReference type="eggNOG" id="COG2113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWMPAQQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033265">
        <property type="term" value="F:choline binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015871">
        <property type="term" value="P:choline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13640">
        <property type="entry name" value="PBP2_ChoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017783">
        <property type="entry name" value="ABC_choline_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03414">
        <property type="entry name" value="ABC_choline_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266598" description="OpuAC domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="48"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35354" checksum="07F4884C016FC816" modified="2004-10-25" version="1">MKRYESIARRLARRAAAASPAFAALAWCAAAAAATTTAAAAEPAACRDVRMAGPGWTDIEATNALAGVVLKALGYRQSVSNLSVPITYQGLKKGQLDVFLGNWMPAQAPLVKPFVDARAIDVLHANLSHAKFTLAVPDYVAAAGVHSFADLAKYAQRFGAKIYGIEPGAPANQNISRMLADKALGPANWQLVESSETGMLTQVERAVRERQWIVFLGWEPHLMNTKFHLVYLSGGDAYFGPDYGGATVNTVARADFASQCANLARLFRQMTFTVDLENGMIAAMLQGKRSAVDAAQHALRANPSLVEAWLDGVRTASGAPGLPAVRAALDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N13</accession>
    <name>Q63N13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabH</name>
        <name evidence="4" type="ordered locus">BPSS0484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525514.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110506.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0484"/>
    <dbReference type="EnsemblBacteria" id="CAH37940">
        <property type="protein sequence ID" value="CAH37940"/>
        <property type="gene ID" value="BPSS0484"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0484"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6636"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDACRQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="108"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="243"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35998" checksum="A9DC2AD56EC953AB" modified="2004-10-25" version="1">MRPNLEIAGLGHALPQRIVDNDEVARVIDTSDAFIRTRTGVRHRRYLAPGQQLADLACPAAERAMAEAGVAPADIDLLIVNTLSPDHHDPSQACYMQPRLGLREIPCFDIRAQCSGGLYGIEIARHFVASGLYRNVLLICAEALSRRIDTSNAGRNLSILLSDGAAAMVLRAQPDATRGLIDLALGADGTQFDLLCTEAPGAKRPNFIDADDIAAGRHYFRMRGADMFADATRRIVDACRRMLDKHRLALGDIGLVVPHQPNLRIIDAVIEQLGLPRERCMISVEDLGNMASAAFPVALSLAREQGRMPAGQLNLLVTYGAGATWACALYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB5</accession>
    <name>Q63NB5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Toprim domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110404.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0382"/>
    <dbReference type="EnsemblBacteria" id="CAH37832">
        <property type="protein sequence ID" value="CAH37832"/>
        <property type="gene ID" value="BPSS0382"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0382"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4376"/>
    <dbReference type="eggNOG" id="COG4643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRGHTAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009270">
        <property type="entry name" value="DUF927"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014819">
        <property type="entry name" value="PriCT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06048">
        <property type="entry name" value="DUF927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08707">
        <property type="entry name" value="PriCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13362">
        <property type="entry name" value="Toprim_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="2">
        <location>
            <begin position="220"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="955" mass="103928" checksum="870D0463FD543510" modified="2004-10-25" version="1">MSNAPMSEFERASVALGYVPADDRDTWRQAGMALKAEFGEEGFTLWNEWSQGAQNYNVRDARDVWKSFKGGKITINTLFHLAKLGGFDPRAHRAMPIDPAQRERQHAERATREAAEMATLTEKQQAASALAESIWSTAEPAPADHPYLVRKRIPADALRVYRGNLSIGTAACDGALVIPARDADGKLWTLEFILTDGQKRYLPNGRKAGCFALIGGAVSSVLLVGEGYATCATLAAATGYPAAVAFDAGNLHAVATALRDQYPDARIVVCADDDHTTNGNPGVTKARAAADAVGGVVAVPDFGPNRPAAGTDFNDVAAHLGPDAVAAAVRAALAVDGSPGSDKGKARPPVTKPAKRPKTARAQDGTWRFEVDDEGVWYHGFNNQGDPLPPHWISTRIDVIAETRNEMSSEWGYLLEFTDRDGIQKRWAVPAGLFAGDGTELRRMLLDMGVKLGVTQTARTQIANYIQMARPDERVRCVPRVGWHHGAFVLPDRVIGTGKEALIYQADTPIQSQFKERGTLDDWRRDVAAYCVGNSRLLFCVATAFAGSLLHFSGLQSGGFHLLGTTSKGKSTGGVIAASVFGSPDYVRSWKATDNALEAVATQHSDALLILDEIGQVEPRLVGDVIYMLANESGKARASRSGSAKPVLTWRLLFLSNGEKSVSALMAEANKPMKGGIEVRLPAIPAEVGDMGVVEELHDFPTPAALIEHLERHAGRYYGTAGPVFIEFASTQADELAEHLRTRVDELVTEWVPDGAHSQVARVAKRFCLVAVAGELATAHGLTGWPEGASVDAARRCFEGWMELRGGAGNSDEAEAVRQVLHFLVAHGDNRFVWMNRAQDDHRPNVPHRAGFKQHVKRNERRTAIASDREYYAEFGGKMSADDAEHVETEYLIEAAVFRKDVCAGFDHKMVAKALMKRGVLMPRSDGYPYRQEYIPGHGKFMVYRVRPSIFTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NS5</accession>
    <name>Q63NS5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cation-transporting ATPase membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSS0224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110244.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0224"/>
    <dbReference type="EnsemblBacteria" id="CAH37669">
        <property type="protein sequence ID" value="CAH37669"/>
        <property type="gene ID" value="BPSS0224"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0224"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4177"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="951"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="223"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="976" mass="99990" checksum="8E822755CD095D5C" modified="2004-10-25" version="1">MQMTKLFAPAAPITTTLLVEGMHCGGCTSRVEQALAQVPGVTGAVADLAAGTATVAAASAIDTARLVAALDAAGYRATVATAPAATGNADARHGRARDEDDDAAAAPHTAAVTLTIGGMTCGGCARRVEQALAAVRGVADAKVDLATMSAKASVARDVDSQTLVAAVEQAGYRANVVRDARAEAAPKPAACPFEDAARSAAPAAAFAVDESSAASPERVATQSFELDIAGMTCASCVGRVEKALAQVPGVARATVNLATEKATVDADADAHVDTARLIDAVKRAGYRASPAIAACAPASRATATADAAAARPASPSADDRKLAEARRERALVIASAVLTTPLALPMFAAPFGVDAALPAWLQLALASIVQFGFGARFYRAAWHALKARAGNMDLLVALGTSAAYGLSIWLMLRDPGHAAHLYFEASAVIVTLVRFGKWLEARAKRQTTDAIRALNALRPDRARIVEHGVERDVPLAQVRVGTVVRVLPGERVPVDGRIEAGVTHVDESLITGESLPVPKEPGERVTAGSINGEGALTVATTAIGAETTLARIIRLVESAQAEKAPIQRLVDRVSAVFVPAIVAIAFATFAGWLVAGAGVETAILNAVAVLVIACPCALGLATPAAIMAGTGVAARHGVLIKDAQALELAQRARIVAFDKTGTLTQGRPTVTAFDAIGIPRGDALALAAAVQRASAHPLARAVVAAFDADADARRSSLAAAHADTPRAVAGRGVEARVDARLLALGSTRWRDELGIAVPDGVARRAAALEAAGNTVSWLMRADAPREALALVAFGDTVKPNARRAIERLAARGIRSALVTGDNRGSATAVAASLGIDEVHAQVLPDDKARVVAQLKATAGDGAVAMVGDGINDAPALAAADVGIAMATGTDVAMHTAGITLMRGDPALVADAVDISRRTYRKIQQNLFWAFVYNLVGIPLAALGWLNPMIAGAAMAFSSVSVVTNALLLRRWKGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PB5</accession>
    <name>Q63PB5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chromosome initiation inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525603.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110054.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37473">
        <property type="protein sequence ID" value="CAH37473"/>
        <property type="gene ID" value="BPSS0030"/>
    </dbReference>
    <dbReference type="GeneID" id="56531524"/>
    <dbReference type="KEGG" id="bps:BPSS0030"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6029"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRNGGQL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017685">
        <property type="entry name" value="ArgP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03298">
        <property type="entry name" value="argP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="32697" checksum="0CD14C7E86D26F6D" modified="2004-10-25" version="1">MLDYALLDALAEVIRHGSFERAAKALNVSPSAVSQRVKLLEERVGSVLVKRGQPCVATTSGALLCRHTERVRMLEAELSGHMPAFAGAQAGAWPTLRVAVNDDSVATWFVDAVGPFCAQSGTLLDLVIDDQDYTAERIRDGSVQGAVTALAEPIQGCRSTRLGRMRYHAVCSPAFHARYFGNGVNRDALRRAPCVMFNPKDSLQARFIRRVTRVDLDPPQHWIPHVAGYLRACEAGLGWGMCPERMVERQIAEGGLIDLSDGRSIDIELYWQSWRLSIGWLDEFSAALKASAAQYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PC4</accession>
    <name>Q63PC4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative iron transport/utilisation related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532447.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110045.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0021"/>
    <dbReference type="EnsemblBacteria" id="CAH37464">
        <property type="protein sequence ID" value="CAH37464"/>
        <property type="gene ID" value="BPSS0021"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0021"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6020"/>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHAFVHG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="30404" checksum="0309E85EF1643D95" modified="2004-10-25" version="1">MTQPTTERAVVRVRHTLKFRLLQVKRVVDVTPHLKRVTLAGDELDDFESASFDDHVKVFFPPPGEDAPARPEFGPNGIVFPQDRPRPVARDFTPRRYDRAARELDLDFVLHHPGPASQWAAQARVGQTLGIGGPRGSFVIPKDFDWHLLIGDDTALPAVARRLEELPAGTRVAVVLEVADPSAQIAFETDANLYVVWRHRGDAASGERGASRLVDALRELPLPAGEGYVWAAGEAAAMRGVREHLCRERGVAKSRIRASAYWKHGAIAVHESLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PG1</accession>
    <name>Q63PG1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185119.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110008.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3415"/>
    <dbReference type="EnsemblBacteria" id="CAH37427">
        <property type="protein sequence ID" value="CAH37427"/>
        <property type="gene ID" value="BPSL3415"/>
    </dbReference>
    <dbReference type="GeneID" id="56593915"/>
    <dbReference type="KEGG" id="bps:BPSL3415"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1772"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FATWFVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="31418" checksum="DE46D7DADEA6D60C" modified="2004-10-25" version="1">MDIFGIPVSAMLSQLLLGLVNGSFYAILSLGLAVIFGLLNVINFAHGALFMLGAMLAWMGLNYLGLPYWAMLVLAPVVVGLFGILIERSMLRWLYKLDHLYGLLLTFGLTLVVEGVFRAIYGSSGQPYDVPALLEGATNVGFMFLPNYRAWVVVASLAVCLATWFVIEKTRLGAYLRAGTENPKLVEAFGVNVPMMVTLTYGFGVALAAFAGVLAAPVIQVSPLMGQPMIITVFAVVVIGGMGSILGSIVTGLMLGVVEGLTRVFYPEASATVVFVIMAIVLLIRPAGLFGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PG6</accession>
    <name>Q63PG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative branched-chain amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL3410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530467.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110003.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3410"/>
    <dbReference type="EnsemblBacteria" id="CAH37422">
        <property type="protein sequence ID" value="CAH37422"/>
        <property type="gene ID" value="BPSL3410"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3410"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1779"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWIVLLD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="347"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH37422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="594" mass="63813" checksum="E5DA447076BECECC" modified="2004-10-25" version="1">MKAILRNKAFWLFLVALFALPALPGAARVPEYWITLLNYIGLYAIVAVGLVLLTGIGGMTSFGQAAFVGVGAYATAFLTTAYGVSPWLGLIAGVVLTALVALVLGVVTMRLSGHFLPLGTIAWGLALFFLFGNLDWLGKYDGINGIPALALFGHAFDTGRSLYYLIWIVVLAAIVSVQNLLNSRPGRAIRALRGGGMMAEAMGVNTGWLRVVIFVYAAVLASISGFLYAHLQRAVNPTPFGLSHGIEFLFMAVVGGVAHVWGAVLGAAIVTVLQDYLQTLLPKLLGAEGNFEIIVFGVLMVLLLQYARQGVWPFVAKLMPREPAARAPGQAAPLPRRARPQAGEALLVVDNVRKQFGGLVAVNDVSFDVLAGQIVGLIGPNGAGKSTTFNLVTGVLRPTSGAITFRGERIDKLVSREIVKRGIGRTFQHVKLLPGMTVLENVAIGAHLRGSAGIWRSVVRLNAHEEARLMSEAARQLRRVGLDGHMYDEAGSLALGQQRILEIARALCSDPTLLLLDEPAAGLRYQEKQQLAELLRKLKAEGMSVLLVEHDMDFVMNLTDRLVVMEFGTRIAEGLPQDVQKDPAVLEAYLGGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM1</accession>
    <name>Q63PM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004542760.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109948.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3352"/>
    <dbReference type="EnsemblBacteria" id="CAH37365">
        <property type="protein sequence ID" value="CAH37365"/>
        <property type="gene ID" value="BPSL3352"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3352"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1851"/>
    <dbReference type="eggNOG" id="ENOG5033EWB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WEIHTAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="100" mass="10837" checksum="CC4865371CE11200" modified="2004-10-25" version="1">MSKQKLTILQVVPRGGISKRTNQPWEIHTAQCVLEQETSEGKQILVGTINLPNALKDSAPGDYLAEFALQQSMEGKLEPRIVSLVPFGRPTAKPAANANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PT1</accession>
    <name>Q63PT1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor FliA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">RNA polymerase sigma factor for flagellar operon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sigma F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sigma-28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">fliA</name>
        <name evidence="8" type="ordered locus">BPSL3291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. FliA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109887.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3291"/>
    <dbReference type="EnsemblBacteria" id="CAH37304">
        <property type="protein sequence ID" value="CAH37304"/>
        <property type="gene ID" value="BPSL3291"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|272560.51.peg.1926"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Sigma70_FliA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028617">
        <property type="entry name" value="Sigma70_FliA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="93"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="182"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="243" mass="27796" checksum="89407105164077BC" modified="2004-10-25" version="1">MYNAQGKISQDEVLTQYAPLVRRLGLQLVAKMPASVDLDDLIQAGMIGLLDAASRYKEDQGAQFETYATQRIRGAMLDELRSNDWLPRSLRKTSREVEHAVHQVEQRLGRSANETEIAAHLQMPLDEYQSMLQDLHGSQLVYYEDFDRSADDEPFLDRYRADHSDPLSALLDEHLRSALVDAIERLPEREKLLMSLYYERGLNLREIGAVLEVSESRVCQLHSQAVARLRAKLREQAWVGTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PU4</accession>
    <name>Q63PU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3278"/>
    <dbReference type="EnsemblBacteria" id="CAH37291">
        <property type="protein sequence ID" value="CAH37291"/>
        <property type="gene ID" value="BPSL3278"/>
    </dbReference>
    <dbReference type="GeneID" id="56593941"/>
    <dbReference type="KEGG" id="bps:BPSL3278"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3729"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="23956" checksum="FBFBBE475AF6C818" modified="2004-10-25" version="1">MSAAPTMPSREIYVSTDVEADGPIPGPHSMLSFASAAFTEDKELIATFSANLELLPGAAAHPVQAAWWKTQPEAWAACRRDLQAPEAALAAYVEWVEALPGKPVFVAMPAGFDFTFMFWYMMRFTGRCPFSWSALDIKTLAFAITGLPYRKAIKPRFPKRWFDDYPHTHVALDDAIEQGALFCNMLADLRALQTAKASAPPVEEADESAQNAADGPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PW1</accession>
    <name>Q63PW1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109857.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3261"/>
    <dbReference type="EnsemblBacteria" id="CAH37274">
        <property type="protein sequence ID" value="CAH37274"/>
        <property type="gene ID" value="BPSL3261"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3261"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1963"/>
    <dbReference type="eggNOG" id="ENOG5032YTH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYQAETG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024640">
        <property type="entry name" value="Toxin-antitoxin_type_1_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12703">
        <property type="entry name" value="ptaRNA1_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10654" checksum="BAB03A658333D398" modified="2004-10-25" version="1">MATMHDTEAREVIHHTAMQLAALEFIDPHAAKDLSEMTEAMVNLFVVVFYQAETGRATRSDFREAMTAVRQALLQYAEQLKCHGGISGKGANEAWS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q19</accession>
    <name>RL29_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmC</name>
        <name type="ordered locus">BPSL3205</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199856.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109799.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q19"/>
    <dbReference type="SMR" id="Q63Q19"/>
    <dbReference type="STRING" id="272560.BPSL3205"/>
    <dbReference type="EnsemblBacteria" id="CAH37216">
        <property type="protein sequence ID" value="CAH37216"/>
        <property type="gene ID" value="BPSL3205"/>
    </dbReference>
    <dbReference type="GeneID" id="60548055"/>
    <dbReference type="GeneID" id="66545628"/>
    <dbReference type="KEGG" id="bps:BPSL3205"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2033"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="PRO" id="PR:Q63Q19"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000007442" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <sequence length="64" mass="7310" checksum="E1E36507A6495895" modified="2004-10-25" version="1">MKASELLQKDQAALNKELSDLLKAQFGLRMQLATQQLTNTSQLKKVRRDIARVRTVLTQKANQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QD3</accession>
    <name>Q63QD3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109685.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37101">
        <property type="protein sequence ID" value="CAH37101"/>
        <property type="gene ID" value="BPSL3090"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3090"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3541"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="89" mass="8858" checksum="713C6D7467A30A22" modified="2004-10-25" version="1">MGHLAINWRKAMQELNQQEIDLVGGATVGGGLIGGLTGLIGAYGGALYDLGANLTGDLVGFATGVVQIGETLVGGTLSNIGSIFTGTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI1</accession>
    <name>Q63QI1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-oxoadipyl-CoA thiolase</fullName>
            <ecNumber evidence="4">2.3.1.174</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">paaJ</name>
        <name evidence="10" type="ordered locus">BPSL3042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:19481"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57348"/>
            <dbReference type="EC" id="2.3.1.174"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.174" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109637.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3042"/>
    <dbReference type="EnsemblBacteria" id="CAH37053">
        <property type="protein sequence ID" value="CAH37053"/>
        <property type="gene ID" value="BPSL3042"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3042"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3473"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFLACNR"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033812">
        <property type="term" value="F:3-oxoadipyl-CoA thiolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012793">
        <property type="entry name" value="PcaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02430">
        <property type="entry name" value="pcaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="9">
        <location>
            <begin position="282"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="405" mass="42283" checksum="AD7A5B76AE801563" modified="2004-10-25" version="1">MPEFDMTEAFLCDAIRTPIGRYGGALAPARADDLGAVPLKALVERNRDVDWAAVDDVIYGCANQAGEDNRNVARMSLLLAGLPHAVPGATINRLCGSGMDAIGLAARAIKAGEASLMIAGGVESMSRAPFVTGKATSAFSRQAEIFDTTIGWRFVNPLMKQRYGVDSMPETAENVATDYRVSRADQDAFALRSQQKAARAQADGTLAQEIAPVTIAQKKGEPLVVARDEHPRETTLEALAKLKGVVRPDGTVTAGNASGVNDGACALLVASEAAARRHGLVPRARVLGIATAGVEPRVMGIGPAPATQKLLARLGMTLDQFDVIELNEAFASQGLAVLRLLGVADDDARVNPNGGAIALGHPLGASGARLVTTATYQLHRTGGRFALCTMCIGVGQGIAIAIERV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM0</accession>
    <name>OBG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">BPSL3003</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
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    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_004194312.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
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    <dbReference type="SMR" id="Q63QM0"/>
    <dbReference type="STRING" id="272560.BPSL3003"/>
    <dbReference type="EnsemblBacteria" id="CAH37014">
        <property type="protein sequence ID" value="CAH37014"/>
        <property type="gene ID" value="BPSL3003"/>
    </dbReference>
    <dbReference type="GeneID" id="56594257"/>
    <dbReference type="KEGG" id="bps:BPSL3003"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2267"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="VVFDWEP"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000385789" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="160"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="372" mass="40150" checksum="21CB4A5F014A09A9" modified="2004-10-25" version="1">MKFIDEARIEVIAGDGGDGSASMRREKFVPFGGPDGGDGGRGGSVYVIADRNINTLIDYRYAKKHMARNGENGRGSDCYGKGGDDITLRMPVGTVINDMDTGELIADLTEHDQKVLVAKGGAGGLGNLHFKSSTNRAPRQKTDGKPGERRMLKLELKVLADVGLLGMPNAGKSTFISSVSNAKPKIADYPFTTLAPNLGVVRVGPGKSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTGLLLHLVDLAPFDERVDPVAEARAIVGELRKYDESLYEKPRWLVLNKLDMVPEDERRARVADFIERFGWTGPVFEISALTGQGCEGLVYAIHDYLVEHSDAHRAELAEDLASDVRFRDAPGAGGEPHERDAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM3</accession>
    <name>Q63QM3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3000"/>
    <dbReference type="EnsemblBacteria" id="CAH37011">
        <property type="protein sequence ID" value="CAH37011"/>
        <property type="gene ID" value="BPSL3000"/>
    </dbReference>
    <dbReference type="GeneID" id="56594254"/>
    <dbReference type="KEGG" id="bps:BPSL3000"/>
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014861">
        <property type="entry name" value="Uncharacterised_CNP1"/>
    </dbReference>
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        <property type="entry name" value="CNP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266254" evidence="1">
        <location>
            <begin position="29"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CNP1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="195" mass="21939" checksum="72F84BCF6F607000" modified="2004-10-25" version="1">MPRLFYEAPILKAIALAAASIAAAAALAGCAHSNTPSNKDDSEFVYLLDRQPQWTENKVDKLPPLPQTSDLLPFNVSQNTPLKFFVDSKSLDVGTDGVVRYIVVVTSPAGARNVNYEGIRCDTYEWRQYAGLNADHSGWDRTIETDWQRIENGELNAYHAALYQDFFCANKMPAAKRPTIIENIRYNRTQLNQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R35</accession>
    <name>Q63R35_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroG</name>
        <name evidence="7" type="ordered locus">BPSL2839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550019.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109433.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63R35"/>
    <dbReference type="STRING" id="272560.BPSL2839"/>
    <dbReference type="EnsemblBacteria" id="CAH36849">
        <property type="protein sequence ID" value="CAH36849"/>
        <property type="gene ID" value="BPSL2839"/>
    </dbReference>
    <dbReference type="GeneID" id="56528359"/>
    <dbReference type="KEGG" id="bps:BPSL2839"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2462"/>
    <dbReference type="eggNOG" id="COG0722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DINTGLR"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="43"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="357" mass="38762" checksum="9EEAED8C388EEE4C" modified="2004-10-25" version="1">MPPHNTDDVRIRELKELTPPAHLIREFALGEAVSELIYNARQAMHRILHGMDDRLIVIIGPCSIHDTKAALEYAGRLVQERERFASELEIVMRVYFEKPRTTVGWKGLINDPHLDNSFKINDGLRTARELLLQINEMGLPAGTEYLDMISPQYIADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNVKIAVDAIKAASQPHHFLSVTKGGHSAIVSTAGNEDCHVILRGGKAPNYDADSVNAACADIGKAGLAARLMIDASHANSSKKHENQIPVCADIGRQIAAGDERIVGVMVESHLVEGRQDLKEGCPLTYGQSITDACINWDDSVKVLEGLAEAVKARRVARGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R94</accession>
    <name>Q63R94_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527651.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109374.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2779"/>
    <dbReference type="EnsemblBacteria" id="CAH36788">
        <property type="protein sequence ID" value="CAH36788"/>
        <property type="gene ID" value="BPSL2779"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2779"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2534"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFFPQKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="15926" checksum="521D965248F4DCE2" modified="2004-10-25" version="1">MIESILIVCEGNLCRSPMAAALFAAALPGRAVTSAGLNALVGLPAAPLAQDVMRERGVDLSAHRAQQLGRAHCASADLILVMDRGQRRLVEERYPLARGKVFRIGEHENFDVHDPYRQPRFVFERSARLLELGVNGWLSRLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RI1</accession>
    <name>Q63RI1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional regulator/uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pyrR</name>
        <name evidence="2" type="ordered locus">BPSL2691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185915.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109287.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2691"/>
    <dbReference type="EnsemblBacteria" id="CAH36699">
        <property type="protein sequence ID" value="CAH36699"/>
        <property type="gene ID" value="BPSL2691"/>
    </dbReference>
    <dbReference type="GeneID" id="56594989"/>
    <dbReference type="KEGG" id="bps:BPSL2691"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2651"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PIQPDFC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="18130" checksum="3C864DAE7A8B0598" modified="2004-10-25" version="1">MSSIDAEALYRVLLDQIRAAYGDAAFAQAGGPVLAGIHSGGAWLAERLARDLGAPGFGVVNVALHRDDYAKKGLHSQASPTSLPFEVEGRRIVLVDDVLYTGRTVRAALNELYDYGRPAAVELAVLADRGGRELPVAARFVGGALAVDADATLVLERADAGRFTLRTEARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ4</accession>
    <name>Q63RZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195993.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109123.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2527"/>
    <dbReference type="EnsemblBacteria" id="CAH36534">
        <property type="protein sequence ID" value="CAH36534"/>
        <property type="gene ID" value="BPSL2527"/>
    </dbReference>
    <dbReference type="GeneID" id="56596430"/>
    <dbReference type="KEGG" id="bps:BPSL2527"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2852"/>
    <dbReference type="eggNOG" id="COG1910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYYFACD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="146"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="368" mass="38852" checksum="B5CA13DB9767123A" modified="2004-10-25" version="1">MIRVECDAHLIVRDTDGRTASLTDVAPLLELVATTGSIAQAAHAKGLSYRHAWGLLRALEACVGGALIETVRGKGSTLSELGQAIVDAQRLAGERLDGNLRALAAEVASGLNRRLALHAGALRIHASHGYAVAALVSALVEAGSPVDIKYRESVEAVRALAGGECDLAGFHLPRGAFRAACAQIYRPWLDDVDHVLIHLTRRRQGLFVPRGNPKRIAGLADLARGDIRFVNRQPGSGTRMLLDLALREIGIDPERIDGYASAELTHSAIAAFVASGMADLGFGVEPAARHFGLDFIAVVDEDYYFACERSRLGAVPLAGALALLRDGGYHATVARLDGYDPNACGTLVDVAAGLAGTAGDARAGRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S80</accession>
    <name>Q63S80_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal RNA subunit accumulation protein YceD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">23S rRNA accumulation protein YceD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in synthesis, processing and/or stability of 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUF177 domain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193919.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109037.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2445"/>
    <dbReference type="EnsemblBacteria" id="CAH36448">
        <property type="protein sequence ID" value="CAH36448"/>
        <property type="gene ID" value="BPSL2445"/>
    </dbReference>
    <dbReference type="GeneID" id="56596360"/>
    <dbReference type="KEGG" id="bps:BPSL2445"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2945"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CMTPYDQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039255">
        <property type="entry name" value="YceD_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38099">
        <property type="entry name" value="PTHR38099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="210" mass="22784" checksum="9B47425F8A982519" modified="2004-10-25" version="1">MNPSSGKPAVSLDPHAIDLFEFARSARQAAGAVRLSQLPRMLNEVPADAPERDTVFTWQAEGSMQPELQDDGTEGAQPYLRLALHGAAWLECQRCMTPYAQSFDIDVVYRIVATEEEAEEFPLDEDEVDVIVGSRQFDLVDLIEEELLLSLPLVPRHEVCPAVHESLVSGASGPAADTDDTSDEAAGESDKPNPFAALEALKKGGEGDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S92</accession>
    <name>Q63S92_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="6">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109025.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2433"/>
    <dbReference type="EnsemblBacteria" id="CAH36436">
        <property type="protein sequence ID" value="CAH36436"/>
        <property type="gene ID" value="BPSL2433"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2433"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2775"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRSVSMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="283"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="485" mass="50683" checksum="ED03191F9399A921" modified="2004-10-25" version="1">MTPLAAQSATAAPNVTTTPAATGAVPAARAGLPDFADLVERVGPAVVNIRTTANVPADTRGALPPGLDNGDMSEFFRRFFGIPLPQGPGGQKNAPSTPDAPDTEQNRGVGSGFILSPDGYVMTNAHVVDDADTIYVTLTDKREFKAKLIGVDERTDVAIVKINASSLPTVAIGDSNRVRVGEWVVAIGSPFGLDNTVTAGIVSAKGRNTGDYLPFIQTDVAVNPGNSGGPLINMQGEVIGINSQIYSRTGGFMGISFAIPIDEAMRVAEQLKASGKVTRGRIAVAIGEVTKEVADSIGLPKAEGALVSSVEPGGPADKAGLQPGDIILKFNGRPVEAASDLPRMVGDTKPGAKATVTVWRKGQSRDLPITIAEFPADKAAKADSRQAPQQKPRSSALGLTVSDLSPEQLKTLKLRNGVQIDAVDGPASRAGLQRGDIVLRVGDVDITSAKQFVDVTSKLDPQRAVAVLVRRGENTQFIPIRPRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SF2</accession>
    <name>Q63SF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533956.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108964.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2371"/>
    <dbReference type="EnsemblBacteria" id="CAH36373">
        <property type="protein sequence ID" value="CAH36373"/>
        <property type="gene ID" value="BPSL2371"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2371"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3036"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VAKIGSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="411" mass="43792" checksum="E15411042418AC9B" modified="2004-10-25" version="1">MTTTATDRAAARAQLAQHGWISRHHESFRHLPPPAADTWLDAEADRADAARPPGAAAHAAWLLAPVGSGSLEQVDACWLGTADRAERAALFADLPTSPDDDAAPFFWAHRALCETGLRLRIGSGPAQRAPTMLQLRLPAQGRVEAPLVVIDVMPGVHCVLVESHEHAAGRDAPLTQNLHAYVRLGAGASLDHLRIATPGARDRIAHHVHVCLQRDAQYRQSLLASGSEYHLQRTVLELRGERAVARASGVLFASSQAKLEQQVRAAHAAPRTRSAIDTLALASGHAQIVANAFSSIAAGASGADLRQRLSGIPTSGEPRVVLRPHLEIHHDDVQAAHGATWGALPEDALFYACQRGLDRRDALAMIVAGMARAALAHGIDTPGRLEALGGDALLAREVSRHLAEQTEARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SF9</accession>
    <name>Q63SF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536312.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108957.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2364"/>
    <dbReference type="EnsemblBacteria" id="CAH36366">
        <property type="protein sequence ID" value="CAH36366"/>
        <property type="gene ID" value="BPSL2364"/>
    </dbReference>
    <dbReference type="GeneID" id="56528823"/>
    <dbReference type="KEGG" id="bps:BPSL2364"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3045"/>
    <dbReference type="eggNOG" id="COG3278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMTQFVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="45834" checksum="0EF3AF9D22325C4C" modified="2004-10-25" version="1">MQRKLELDHSPALSVPLRFFVSAPLFALAAAGLLLWAGPDTLASRWSPAALALTHLCALGMLATTMVGAMIQIMSVAAGIRIAAPVASATAIHACLTLGTLLLAAAFACAAPVLFAPAALLLGAAFAWFLLVCAIGFARERRRMPAGAAAVLRTVRLAWLALAATVALGASLGFALGGHLPVFSVELVDLHAAWGLAGWVGLLTIGISYQLIPMFQATEPYPRAVARGLGPGVFAALVAASAVTFGPAGRAGFAADAIRLALYVLYAAFAAWTLHLLRTRKRPEADTTTLFWRTATASVAGAGALWIANAGMGGRDIAVTTGVLLMMGGAWSAINGMLYKIIPFLLWYHAQKSSETAIPGMPKVKEMLPERVARPQFFAHVAALLLLVAASVAPAPFARPAAVVLGVSAGWLALNMLGAWRRYARVRRRVASVLHLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SI4</accession>
    <name>Q63SI4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524698.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108932.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2336"/>
    <dbReference type="DNASU" id="3094764"/>
    <dbReference type="EnsemblBacteria" id="CAH36339">
        <property type="protein sequence ID" value="CAH36339"/>
        <property type="gene ID" value="BPSL2336"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2336"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3087"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPGQHEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="107"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="444" mass="49734" checksum="A6E0D0F3836D0965" modified="2004-10-25" version="1">MQDIDDFLRQHRITEVEAIIPDMAGIARGKIIPRNKFETGESMRLPQAVMVQTVTGDYPEDGTLTGVTDPDMVCVADASTICLIPWAVDPTAQVIHDCVHFDGSPVEISPRYVLRRVLDLYRARGWKPVVAPELEFYLVDMNKDPDLPLRPPVGRTGRAETGRQSYSIEAVNEFDPLFEDIYEYCELQGLDIDTLIHEVGAAQMEINFLHGDALSLADQVFLFKRTVREAALRHNMYATFMAKPMESEPGSAMHIHQSVVDIETGRNLFIGASGDVTPMFRSYLAGLQKYTPALMPIFAPYINSYRRLSRFMAAPINVQWGYDNRTVGFRIPHSAAAARRIENRIPGVDCNPYLAIAGTLAAGYLGVTQGLEPTEPLASDGYSLPYQLPRNLEEGLTLMSACAPLAEMLGEKFVKAYLALKETEYEAFFRVISSWERRHLLLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SM3</accession>
    <name>Q63SM3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Family S11 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL2297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108893.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="S11.002"/>
    <dbReference type="EnsemblBacteria" id="CAH36300">
        <property type="protein sequence ID" value="CAH36300"/>
        <property type="gene ID" value="BPSL2297"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2297"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2607"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDIKLTK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266754" evidence="10">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="102"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="359" mass="38314" checksum="79894B538123359B" modified="2004-10-25" version="1">MALGTAVSVAVSLMVATAAVAPADAFAATAKTAQSAKGKKSAAKKSLRAASSSAEPRAKGARKRVTYVSNGRHRSGVRRVAFQPRPPSVGQAFGLHETPDSLALRSSVAYVVDQNTSEPLFDKNSHAVVPIASITKLMTAMVVLDSKSPLTDQIDVTDEDRDYEKGTGSRLSVGSVLSREDMLHIALMASENRAAAALSRYYPGGRPAFIAAMNAKAKSLGMTDTHFENSTGLSSQNVSSARDLVKMVNAAYQYPLIRKFSTDRSYEVNTGKRTLAYNSTNALVRNPSWDIGLQKTGFINEAGECLVMQTTIHGRPIVMVLLDSFGKYSRFADASRVRNWLDNGGGERLTAANTSTGGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SX4</accession>
    <name>SYE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">BPSL2197</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532170.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108792.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SX4"/>
    <dbReference type="SMR" id="Q63SX4"/>
    <dbReference type="STRING" id="272560.BPSL2197"/>
    <dbReference type="EnsemblBacteria" id="CAH36199">
        <property type="protein sequence ID" value="CAH36199"/>
        <property type="gene ID" value="BPSL2197"/>
    </dbReference>
    <dbReference type="GeneID" id="56528993"/>
    <dbReference type="KEGG" id="bps:BPSL2197"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3250"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000119530" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="469" mass="52177" checksum="74926E43806AB43A" modified="2004-10-25" version="1">MTRPVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGTFVLRIEDTDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYREVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDGTWRPEPGKVLPEPPAGVTPVLRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIRGDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEAVLNYLARLGWSHGDAEIFSREQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARLAELAKPFFAALGIDADTIARGPDLVGVMGLMKDRASTVKEIAENSTMFYRAPAPDAQALAQHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHTPSIDAVLLLFGRDVVVSRLAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T29</accession>
    <name>Q63T29_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Family S53 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108737.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2142"/>
    <dbReference type="EnsemblBacteria" id="CAH36144">
        <property type="protein sequence ID" value="CAH36144"/>
        <property type="gene ID" value="BPSL2142"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2142"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3312"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WANETVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267532" evidence="7">
        <location>
            <begin position="34"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="8">
        <location>
            <begin position="246"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="629" mass="64678" checksum="7A23830A08D97DC0" modified="2004-10-25" version="1">MTSRKWARPRASQAKHAIYAATFFAAAALSAHAAAAWVDTQTGAYPALAQQALAASQASAAAATAAGKAIDTAPGEPVRVVVSLNLNDEARLDRFLRDLHTPGSAAYGRHLTPAEFAAQYAPTPQQVALVEAHLRRAGFRDIEVAPNRLLISATGTAAAVKTAFNTRLKRFTLEGRRVYANQDAAQVPAELGRIVGAVLGLDNATLARTYNRQAAVTGAVGGAKASLAARASDASAAASGAPVLTGHDPLEFSRIYRAGSTPTASQTTVGVIMAGDAAPVLRDLDTFAAKAGLARVAATVTRTGPPGSDYSDNSGLSEWDMDSQAIVGAAGGAVKGLVLYAAPSMLLSDITSAYNRAVVDNVAKVINVSLGVCEADARASGTQAADDRIFKSAVAQGQTFVVAAGDAGAYECSVSRVSGGQGVPARSNYSVSEPATSPYVVAVGGTTLSTDRTTLAYAGEVAWNEGLQPIGVYDAYGSYDGTRRLWATGGGYSRSEAAPAWQRSVLGASAKARALPDVAFDADGRSGAHVYVNGRTEQWGGTSLAAPIFTGIWARVQSDNGNRLGFPLASLYRYAPANGAFAHDVKSGNNGSGGYGYKAGAGWDPVTGFGSLDIANFAAFVKQTADFAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TF9</accession>
    <name>SYA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="1">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alaS</name>
        <name type="ordered locus">BPSL2009</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004204967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108607.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TF9"/>
    <dbReference type="SMR" id="Q63TF9"/>
    <dbReference type="STRING" id="272560.BPSL2009"/>
    <dbReference type="PRIDE" id="Q63TF9"/>
    <dbReference type="EnsemblBacteria" id="CAH36008">
        <property type="protein sequence ID" value="CAH36008"/>
        <property type="gene ID" value="BPSL2009"/>
    </dbReference>
    <dbReference type="GeneID" id="56526375"/>
    <dbReference type="KEGG" id="bps:BPSL2009"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4163"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000075082" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <sequence length="874" mass="94695" checksum="3F520EF335DD7563" modified="2004-10-25" version="1">MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRATTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTSVYKLPADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGARYASDNFWQMGDTGPCGPCSEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERIAAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKLGRKAPFFHKLVADLVAEMGAAYPELKEAEPRVTDVLRQEEERFFETIEHGMSILEAALAELDAAGGKTLDGELAFKLHDTYGFPLDLTADVCRERGVTVDEPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVGEVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVGDTLKVQADVIGHHGELEQGTLKVGDVVRAEIDAARRARTARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAHNAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGGAMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAALKAQPSELLQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGADAKTLRETVDKLKDKLKSAAIVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPAKLPAALAGVKGWVEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TS1</accession>
    <name>Q63TS1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported fimbriae assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192085.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108495.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1895"/>
    <dbReference type="EnsemblBacteria" id="CAH35895">
        <property type="protein sequence ID" value="CAH35895"/>
        <property type="gene ID" value="BPSL1895"/>
    </dbReference>
    <dbReference type="GeneID" id="56595695"/>
    <dbReference type="KEGG" id="bps:BPSL1895"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4038"/>
    <dbReference type="eggNOG" id="COG4964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMIVTPH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032789">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13629">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266775" evidence="2">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="T2SS-T3SS_pil_N" evidence="3">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="441" mass="45226" checksum="7033A33B16E8312F" modified="2004-10-25" version="1">MKNKLIAWAVAFGVLLSFAARAAETGTIELAAGTQRQIAVGHGVQRVAIADPNVADVLVIKGGRGGVLLVAKAAGTTSLMVWERGRDEPAAYTVNVVSGAARALLDGGSPSVKAYNGTAVVAGSAATLDAHARALAVGKGMAGKDGGVLDVSTVGGKNVVQVDVRVVEFSRSVLKQAGLNFFKQNNGFTFGSFAPAGLASVTGGGTSSMSVSANIPIASAFNLVVGSATRGLFADLSILEANNLARVLAQPTLVALSGQSASFLAGGEIPVPVPQSLGTISIDWKPYGVGLTLTPTVLSPRRIALKVAPESSQLDFVHSITINGVTVPALTTRRADTTVELGDGESFAIGGLIDRETTSNVDKVPFLGDLPIIGTFFKHLSYQQNDKELVIIVTPHLVAPIAKNASLPATPGELSEQRDGPVWRSYLGGVLSPDAGPGFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU7</accession>
    <name>Q63TU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191707.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108469.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1870"/>
    <dbReference type="EnsemblBacteria" id="CAH35869">
        <property type="protein sequence ID" value="CAH35869"/>
        <property type="gene ID" value="BPSL1870"/>
    </dbReference>
    <dbReference type="GeneID" id="56595663"/>
    <dbReference type="KEGG" id="bps:BPSL1870"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4005"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DDPVPSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="26924" checksum="DD5445A49B922A1F" modified="2004-10-25" version="1">MEQGKDRSLVSKVMDGLVTGIVEDKYGGVLPPQDVLSKEFDVSRTVMREALSMLLARDMLDVRPKVGTRVRPMSHWRMIDEDVVNWRFRAKPDRQFIRDVIEFRTLIEPRATAQAASRATTAEIAGIREAYELFKLAEPGTPAYDEADELLHTRIVHASGNQFFQQMAAIIRGALRVVNPRMSQRDDIRALALKSHGRVVDAIERRDARDAEAAALELIDYTAEEMRDFAVDMPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TW9</accession>
    <name>Q63TW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526891.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108447.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35847">
        <property type="protein sequence ID" value="CAH35847"/>
        <property type="gene ID" value="BPSL1848"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1848"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3977"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PPYSLFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="350" mass="38748" checksum="8EBF565041F8AB4C" modified="2004-10-25" version="1">MEYRTLGDSGVKVSLIGLGTMTWGEQNTESDAHAQLDYAIDQGVTLIDTAEMYPVPPKAQTQGRTETYLGTWLAKHPALREKLTIATKIAGPARQPHNPTHIRGAGNQFDRKNLTEALDGSLARLRTDYVDLYQLHWPDRSTTTFGRPAYPWIDDPYTVPIEETLAVLGDFVKAGKVRHVGVSNETPWGVAQFLRAAEKLGLPRIVSIQNPYSLLNRTFENGLSEFSHRERIGLLAYSPLAFGWLSGKYEGGARPEGARITRFERFQRYSKPHAVQATSRYVALARRHGLSPAQLALAFVNSRPFVTSNLIGATSLAQLRENVASVDVKLAPEILAEIDALHEQQPNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U31</accession>
    <name>Q63U31_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526940.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108385.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1785"/>
    <dbReference type="EnsemblBacteria" id="CAH35784">
        <property type="protein sequence ID" value="CAH35784"/>
        <property type="gene ID" value="BPSL1785"/>
    </dbReference>
    <dbReference type="GeneID" id="56595572"/>
    <dbReference type="KEGG" id="bps:BPSL1785"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3893"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HNEQAYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="35"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="37396" checksum="06CCEAB0C383914C" modified="2004-10-25" version="1">MTQLSMPAAAACPTLGDLRVEPGLPTVVSPRDGADIALHEAAPLLREIADDVLERAGGVLFTGFRVASIETFQRFAADFGDPLIGYEFASTPRSQVEGAVYTSTEYPPHRSIPLHNEQSYTREWPLRIWFHCALAARTGGATPIADSRAVYRALDPALVARFAERELLYVRNFGQGLDLPWQQAFGTGDPREVERICAARGIGCEWRDGDDGEPLLRTRERCQAVARHPRTGELVWFNQANLFHLSALDEDMQEALVDAVGIENVPRNVYYGDGAPLEPDALAEIRAVLDGQRIVFPWQTGDVLMLDNMLSAHARDPFEGPRKVVVAMARSYREKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U60</accession>
    <name>Q63U60_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative precorrin-6X reductase</fullName>
            <ecNumber evidence="4">1.3.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobK</name>
        <name evidence="4" type="ordered locus">BPSL1756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.54" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108356.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1756"/>
    <dbReference type="EnsemblBacteria" id="CAH35755">
        <property type="protein sequence ID" value="CAH35755"/>
        <property type="gene ID" value="BPSL1756"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1756"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3856"/>
    <dbReference type="eggNOG" id="COG2099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THPYAAQ"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="25621" checksum="0EEC97C949802A02" modified="2004-10-25" version="1">MRRVLLLGGTGDALRTARALAPHDVYSLAGLGRVPDDLACGVRVGGFGGADGLARYLREHAVALVVDATHPFAARISANAAAACRAAGVPYWALRRAPWRPRPGDDWRGVADWAGVLAAIAPFARPLFTLGREPLAHLDEIAPHQHWLVRCLDAHAGNARAHVLAARGPFSLEGERALFAAAAIDVVVSKNSGGAATEAKLDVARERRVPVVMVERPALPDADREFGATAALVDALRAWRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UA2</accession>
    <name>Q63UA2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527001.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108314.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63UA2"/>
    <dbReference type="STRING" id="272560.BPSL1714"/>
    <dbReference type="EnsemblBacteria" id="CAH35713">
        <property type="protein sequence ID" value="CAH35713"/>
        <property type="gene ID" value="BPSL1714"/>
    </dbReference>
    <dbReference type="GeneID" id="56529397"/>
    <dbReference type="KEGG" id="bps:BPSL1714"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1923"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETDCEVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="386" mass="40513" checksum="42B1F556463CCB50" modified="2004-10-25" version="1">MTRTTAAAKAAVSTTNRRSEAGRPNQWIDAMIDFLSDTVTLPTAEMRHAMFTANVGDDCYGEDPTVNELESVAAGLTGKEAAAFVTSGTLGNLSALLAQCPRGHEVILGDRSDLYNYEAGGVSLVGGAVLHPVETADDGSLPLERLRAAIRDKRDPQCAPAAVIALENPHCLAGGRVLSLDYLRRVRALADEHGLAVHMDGARLFNAQASLGTPAAEIVAHVDSVQFCLSKSLAAPYGSMVCGSAALIDRVKRYRKLLGGGTRQAGIMAAAGLVALRTMVARLADDHRRAARLAAELARIPGVALRSAVIETNMVFFDVAEPGNEAFLAALRDAGIRMGVLGDGVIRAVVHYMIDDDAISRTVDAVRAIVLPFAPALAPAAASQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UE1</accession>
    <name>Q63UE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative toxin transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL1664</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108275.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1664"/>
    <dbReference type="EnsemblBacteria" id="CAH35662">
        <property type="protein sequence ID" value="CAH35662"/>
        <property type="gene ID" value="BPSL1664"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1664"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1876"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWFWSTL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="209"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="521"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="557"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="766" mass="82583" checksum="D472FD00366D5C3A" modified="2004-10-25" version="1">MQAMSDTIPAIEHSAAESDDRTVERMGGPDAASELPLLARVHRMLAAAVTEAGRALGRGVSFDALLAGLTDGKDAMGQVDVIGLIEAAKAFGLVVESVDVPAASKLGTTSLIAIDTESAQDQVLFFPSVEMPHERRAFRFNATGLCQYFEYRQDQVPTGVGVQWLRVDRVPYSATAGARDAGHRPLPSKEHMAWLWDVLLAEKSAFRYALIASLGSTLIGLAMPFFSLVIFNTVAPNGAVATLITLMIGMLVAIAADFVLREVRAYIIDVTARRIDVVLSRRIYEHLLDIKLESWTGVAGTQADMLRGFATVQEVFTSGVLLLLIDLPFGLIALAMVFVVGGHLGWVPVFWVMVLLALLWRMQSSVHRSSQLSMQLGQERHGTLVETINALETVRAVGGERVLRRRWRDQTAMAAIASGTSRMLTQFVAGVTTMSMQLESLMLLGIGAWMVGEKWLTLGGLIAANMLAGRALAPFLSIVSLGIRLESARIAAGFISRFFQMPRTTRETQEFVARSDFTGVVTLNDVSFAYPAHKSGRATVANVNLTVGAGERVAILGRMGSGKSTLLKLMAGVLSPMRGSVLYDGTDLAQLDLVTRRKVVGYLQQNPVLVSGTLKENITLGCPDASDERVLRAAKIAGVDDFARTHPDGYSMRLGEHGRGLSEGQKQVVGLAQLLLNDPYAILLDEPSSSLDLEAENRLVHALKTSLVDQALVVVTHRPAFLQLVSRIIVIDSGCVVLDGPRDDVLAKLSGRTQQTAGAKGMSSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UG0</accession>
    <name>Q63UG0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527058.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108256.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1646"/>
    <dbReference type="EnsemblBacteria" id="CAH35643">
        <property type="protein sequence ID" value="CAH35643"/>
        <property type="gene ID" value="BPSL1646"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1646"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3721"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRYHDTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="347" mass="39301" checksum="DE7C2875F0AC8097" modified="2004-10-25" version="1">MKFSLFLHMERYDAKTSHRDLFDQMTELVQLAERGGFETAWIGEHHAMEFTIAPNPFVNLSYLAAKTERIRLGTGTVIAPFWHPIALAGEAGMVDVASNGRLDLGIARGAYSFEYERLLPGLDAMSAGARMRELVSALRQLFKGDYAHQGEFWSWPSSTPVPRPIQQPHPPMWLAARDPNSHAFAVAHGCNVQVTSLAAGDAEVVSLMERFNAACAANPQVPRPEVMMLMHTFVGANAAEVDAAVEDLARFYRYFSKWFKNERPIEQGFIESLTDVDVEMFPQYSPENIRKNLVIGEPKQVIERLTRYEALGYDQYSFWLDSHMSFERKRKSVELFISEVMPAFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UN4</accession>
    <name>Q63UN4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108182.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1562"/>
    <dbReference type="EnsemblBacteria" id="CAH35563">
        <property type="protein sequence ID" value="CAH35563"/>
        <property type="gene ID" value="BPSL1562"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1562"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1756"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHHYDVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="162"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="467" mass="50224" checksum="719FD53B84B406C9" modified="2004-10-25" version="1">MAELAANAAAGRAAGAPCMNQRDAIPIVPISPPDVGVLVSYLEQDPQPMIVLDPSYRILAANAAYQRQFGIAGEAHVGRRCYQVSHHYDMPCDQAGEHCPMKQAGESRGLNRVLHIHHTPRGPEHVDVELRPIFDARGAVIAYVERLTTVRSASAKPSGEGLVGGSDAFNAALSALQRVAPSMLPVLLLGESGTGKELFARALHEASARAMGPFVVVDCSGIAETLFESELFGYEKGAFTGASARKPGLVETAQGGTLFLDEIGDVPLSMQVKLLRLIESGTFRRVGGVEALCADFRLVAATHKPLKAMIGDGRFRPDLYYRISAYPISLPAVRERPGDMPLLVDSILRRIAALGPVAGQHFVVAPDALARLEAYAWPGNIRELRNVLDRACLLTDDGVIRVEHLPDEVAGGARIEPGAPAKLSDDELARIARAFDGTRRALAERVGMSERTLYRRLRALGIATREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UQ5</accession>
    <name>Q63UQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527147.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108161.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1541"/>
    <dbReference type="EnsemblBacteria" id="CAH35542">
        <property type="protein sequence ID" value="CAH35542"/>
        <property type="gene ID" value="BPSL1541"/>
    </dbReference>
    <dbReference type="GeneID" id="56529265"/>
    <dbReference type="KEGG" id="bps:BPSL1541"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3582"/>
    <dbReference type="eggNOG" id="ENOG5033Y1E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HITGNWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266353" evidence="2">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="193" mass="19024" checksum="2BF75997D3CB2CE0" modified="2004-10-25" version="1">MKLITAIRGAALAAALATAAGLAFAQSSSARAAAAPGAADAAPAAATAQADAPPPAVPLKPNPAYARLPRYEGTVGGRPVVVRLGPKTDEPGVHGECQYLDTGAVILLAGDRDGDTLEIEESDDGTNITGVWIGRFDPSGGLSADRMNADQSDPLPVALHPAGAQSASAAVGAPQAGARGQSVGGVSNLRTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UR2</accession>
    <name>Q63UR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Poly-beta-hydroxybutyrate polymerase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phbC</name>
        <name evidence="6" type="ordered locus">BPSL1534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527151.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108154.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1534"/>
    <dbReference type="ESTHER" id="burma-q62jy7">
        <property type="family name" value="PHA_synth_I"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35535">
        <property type="protein sequence ID" value="CAH35535"/>
        <property type="gene ID" value="BPSL1534"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1534"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3574"/>
    <dbReference type="eggNOG" id="COG3243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIYGSRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010963">
        <property type="entry name" value="PHA_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010941">
        <property type="entry name" value="PhaC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07167">
        <property type="entry name" value="PhaC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01838">
        <property type="entry name" value="PHA_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PhaC_N" evidence="5">
        <location>
            <begin position="106"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="601" mass="66027" checksum="5036CA5E37C2C76F" modified="2004-10-25" version="1">MQQLFESWLGAWRSFADPARAAAGDAPSPSPSPFAAFQPPQPFAFAMPAMPPMPDWSGAAASFAGLAPVASVPPARLQKLQADYSRDCLALIQQASAATPTVPELKDRRFSADAWKASPAHGFAAAWYLLNARYLQELADALETDPKTRERIRFTVQQWTAAASPSNFLALNPEAQKNLVETQGESLRLGMMNLLADMQRGKISQTDESQFVVGKNLAVTPGAVVYENDLIQLIQYTPTTATVFERPLLIVPPCINKFYILDLQPENSLVAHALSCGHQVFLVSWRNADASVAHKTWDDYIDEGLLAAIDVVQQVSGREQINTLGFCVGGTMLATALAVLAARGEHPAASMTLLTSMLDFSDTGILDVFVDEAHVQMREQTIGGKGGAPAGLMRGVEFANTFSFLRPNDLVWNYVVDNYLKGRTPAPFDLLYWNGDSTSLPGPMYAWYLRNTYLENKLREPDALTVCGEPVDLSRIDVPTFIYGSREDHIVPWQTAYASTSLLTGPLKFVLGASGHIAGVINPPAKRKRSYWSYDASAKELPESANDWLDAAVEHPGSWWPVWIEWLDQYGGKKVKPRAHLGCARFPVIEPAPGRYVLQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UT1</accession>
    <name>Q63UT1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193441.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108135.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1515"/>
    <dbReference type="EnsemblBacteria" id="CAH35516">
        <property type="protein sequence ID" value="CAH35516"/>
        <property type="gene ID" value="BPSL1515"/>
    </dbReference>
    <dbReference type="GeneID" id="56595746"/>
    <dbReference type="KEGG" id="bps:BPSL1515"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3552"/>
    <dbReference type="eggNOG" id="COG2976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFFANNG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026039">
        <property type="entry name" value="YfgM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38035">
        <property type="entry name" value="PTHR38035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006170">
        <property type="entry name" value="YfgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="3">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="22567" checksum="415BD667E2E1137D" modified="2004-10-25" version="1">MSYHDEQESIESLKAWWARWGNLTTWVAIAVLAAAAAWNGWNYWQRRQATQAAVLYEQAQQAVRSNDKAKISRVASDMEDKFGGTAYAQMTALEAAKALYGAGDAAGAKAQLQWAADHAKDDEYKQIAKLRLASLLLDEKAYDAGLALLSGTPSDAFKGAVADRRGDLLAAQGKSDDAKAAYKLALDALPKDDASARQLVQFKLDALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UT9</accession>
    <name>Q63UT9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192869.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108127.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1507"/>
    <dbReference type="EnsemblBacteria" id="CAH35508">
        <property type="protein sequence ID" value="CAH35508"/>
        <property type="gene ID" value="BPSL1507"/>
    </dbReference>
    <dbReference type="GeneID" id="56595754"/>
    <dbReference type="KEGG" id="bps:BPSL1507"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3544"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IQWGRGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="286" mass="31004" checksum="882D8DCB43AE3BED" modified="2004-10-25" version="1">MRLISWNVQWGRDANGTVDLARTVDAARGLGDFDVLCAQELTRGFHALPGGPSGDQYAELAALLPGYAVFDAIGVDLPPLEPGAPRRQFGNALATRLPVERALRHALPWPASAAAPSMPRCALEVTLRAPFGPLRVVVTHLEYYSAQQRLAQVDALRRLHREAAAHARASAPPETPASPFAPSARAADAIVCGDFNSAYRSDAYRRFLAPFPDAPRFVDAWLARHPGKTPPMTAGVYDTAQWSEGPMTCDFAFVTDTLVRRLSRCEIDGTVRASDHQPIVLELSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V27</accession>
    <name>Q63V27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527207.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108039.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1417"/>
    <dbReference type="EnsemblBacteria" id="CAH35419">
        <property type="protein sequence ID" value="CAH35419"/>
        <property type="gene ID" value="BPSL1417"/>
    </dbReference>
    <dbReference type="GeneID" id="56529140"/>
    <dbReference type="KEGG" id="bps:BPSL1417"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3436"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDAFIPE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="177" mass="18078" checksum="28DB241CDF3E4AB2" modified="2004-10-25" version="1">MTAAATAPGGAVTLRGERAGDAAALARVIVAAFADEPQGGQFERRIVDALRADGRLSVSLVAVRDGRLVGHVAFSPVAIGAGGEGWHGLAPLAVWPGCQRQGIGAALVRAGLDALRRAGARGCVVLGEPAYYARFGFGPAGDIVFPQAPPDALMALPFGEHAPRPAGALRYHASFYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V41</accession>
    <name>CLPP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP</name>
        <name type="ordered locus">BPSL1403</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193408.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108025.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V41"/>
    <dbReference type="SMR" id="Q63V41"/>
    <dbReference type="STRING" id="272560.BPSL1403"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="CAH35404">
        <property type="protein sequence ID" value="CAH35404"/>
        <property type="gene ID" value="BPSL1403"/>
    </dbReference>
    <dbReference type="GeneID" id="56595863"/>
    <dbReference type="KEGG" id="bps:BPSL1403"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3415"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179523" description="ATP-dependent Clp protease proteolytic subunit">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <sequence length="217" mass="23835" checksum="0A090453746E2F35" modified="2004-10-25" version="1">MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVNDQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAASMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIEIQAREILYLRDRLNHLLAHHTGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V93</accession>
    <name>Q63V93_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550651.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107973.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1348"/>
    <dbReference type="EnsemblBacteria" id="CAH35346">
        <property type="protein sequence ID" value="CAH35346"/>
        <property type="gene ID" value="BPSL1348"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1348"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.133"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYHFSAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="242"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="37509" checksum="A8BCF2E9EDF0F71B" modified="2004-10-25" version="1">MTAKLAHWDFVRPVATTRVLVDVGVEQGLAVGQCLGGSGVCADLLDKPDATVAAAQELRIVRNLMRLLGPDFPLGIEIGRRYHATAYGVWGFALMSSATFGDAVSVGLRYLQLTSTFCEIRPTLRGDDATLMIDDRDLPGDVRDVLVEITVAALITLQFDLDAANLPVKRLALKMKPPSYAGRFRTLFDATPEFGAAHNALTVDVRCLDLKLPQRNALTRRRCEDECRRVLERHRRSEGWAGRVRRQLAGDPARGPTMDVLAAELGVSPRTLRRRLANEGTDYETVADELRQALAEALLATTTLTLAEVSERLGYSEPSAFARAFRRWKGMSPSEYRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VB8</accession>
    <name>Q63VB8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL1323a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531104.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107948.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1323a"/>
    <dbReference type="EnsemblBacteria" id="CAH35321">
        <property type="protein sequence ID" value="CAH35321"/>
        <property type="gene ID" value="BPSL1323a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1323a"/>
    <dbReference type="eggNOG" id="ENOG5032SB1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CIALDMD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005560">
        <property type="entry name" value="DUF326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03860">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="11440" checksum="606EBA384C8BC9B5" modified="2004-10-25" version="1">MNERYEACMRACDACARACDQCAVACLREPDASGLAACVRLDVDCALMCRFASGAIARRSARAGDVCRLCADICEACARECDKHAHAHCRECAHACRACASACVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF8</accession>
    <name>Q63VF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936979.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107908.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1287"/>
    <dbReference type="EnsemblBacteria" id="CAH35281">
        <property type="protein sequence ID" value="CAH35281"/>
        <property type="gene ID" value="BPSL1287"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1287"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.220"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSPLWGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="162"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="310" mass="32362" checksum="52EDBDAA72C77FB9" modified="2004-10-25" version="1">MNLKNALLLIVLAALWGASFLFIRVGVAEFGVAPLMALRVGIGALFLVALMLTRYAPRELIALLRQHAWPLFVVGLLNSAAPFCLFAFAELTLSAGVTSVINATTPLWGALVAYLWLKDSLSLPRALGLVIGFAGVLTLVWDQVFSPHGANPASPATAALAAAAALGATLLYGIAANFTKRKLTGVDPLVSATGSMVGATILLLPFALATWPAAPVSAHAWGSVLALGIACTGVAYFIFFHLIAHIGPARAITVTFVIPVFGILWGALFLGERVSFAMLEGCVIVLLGTALATGAIRRIPGVRPQRNETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VK5</accession>
    <name>Q63VK5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531895.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107861.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1240"/>
    <dbReference type="EnsemblBacteria" id="CAH35234">
        <property type="protein sequence ID" value="CAH35234"/>
        <property type="gene ID" value="BPSL1240"/>
    </dbReference>
    <dbReference type="GeneID" id="56595174"/>
    <dbReference type="KEGG" id="bps:BPSL1240"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1371"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DSNIWVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="2">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="222" mass="23395" checksum="B5813BF1C78AE2DB" modified="2004-10-25" version="1">MPSSDAPRAGRRVVLDSNVWIDILVFDDPAARPIRDALETGAITALIDVRCLIELERVLDYPQFKARAVDKAAALATVARLSERVAGPERGDARAHAATAAGAHASPALAASPAHIADSGNARSGACGTPAPHARACPPPCADAAARAPADDAPPRPLPKCRDRDDQKFLELAYTARADWLVSKDRALLKLTRRTERDFGFRIAQPAPFAASALAADASEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ6</accession>
    <name>Q63VQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203514.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107810.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1188"/>
    <dbReference type="EnsemblBacteria" id="CAH35183">
        <property type="protein sequence ID" value="CAH35183"/>
        <property type="gene ID" value="BPSL1188"/>
    </dbReference>
    <dbReference type="GeneID" id="60546729"/>
    <dbReference type="KEGG" id="bps:BPSL1188"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.340"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YHYPAKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025722">
        <property type="entry name" value="TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13972">
        <property type="entry name" value="TetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="239" mass="28472" checksum="4839ED5ED09D2A74" modified="2004-10-25" version="1">MEAKPPRRTRERILELSLKLFNEIGEPNVTTTTIAEEMEISPGNLYYHFRNKDDIINSIFAQFEQQIERRLRFPEDHRPTIDETWSYLQYMADFMWTYRFLYRDLNDLLARNRTLETHFKQIISHKVRFAREMCELLAADGELVATPAEIEVIATNMAVIATYWLSYQYVMHPRKYNDQDAIREELHQVSMHVISVIAPYLRGRSRQIFDDLVSGKLPKREFHDYLPPRDGSPRKDTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU5</accession>
    <name>Q63VU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936869.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107771.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1150"/>
    <dbReference type="EnsemblBacteria" id="CAH35144">
        <property type="protein sequence ID" value="CAH35144"/>
        <property type="gene ID" value="BPSL1150"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1150"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.390"/>
    <dbReference type="eggNOG" id="ENOG5031DFG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIAHITT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="83" mass="8894" checksum="D811750373D33B40" modified="2004-10-25" version="1">MVDTIKSLDDALRESIDESNIAIEGFQRISDLLKVIEHLASANGIAHITTVAKEASLIALEYGDIASTGRGAFEASRKEVLHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX7</accession>
    <name>MSBA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent lipid A-core flippase</fullName>
            <ecNumber evidence="1">7.5.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msbA</name>
        <name type="ordered locus">BPSL1118</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + lipid A-core oligosaccharideSide 1 = ADP + phosphate + lipid A-core oligosaccharideSide 2.</text>
            <dbReference type="EC" id="7.5.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186431.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107739.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VX7"/>
    <dbReference type="SMR" id="Q63VX7"/>
    <dbReference type="STRING" id="272560.BPSL1118"/>
    <dbReference type="EnsemblBacteria" id="CAH35111">
        <property type="protein sequence ID" value="CAH35111"/>
        <property type="gene ID" value="BPSL1118"/>
    </dbReference>
    <dbReference type="GeneID" id="56595067"/>
    <dbReference type="KEGG" id="bps:BPSL1118"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.430"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGTYLVK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011917">
        <property type="entry name" value="ABC_transpr_lipidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02203">
        <property type="entry name" value="MsbA_lipidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51239">
        <property type="entry name" value="MSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092572" description="ATP-dependent lipid A-core flippase">
        <location>
            <begin position="1"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="353"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="389"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01703"/>
        </source>
    </evidence>
    <sequence length="596" mass="64839" checksum="14EFC6B399B2C0FF" modified="2004-10-25" version="1">MSVKPTLSKPIGGQDASSPAVVMRRLWPYVKPLVWVLVAGVLAMAAVAATEAGIPALLKPLLDHGFGSKGDMTTKLYVPAAVVGLALARAIAQYASGYLLQYVSNRILLDLRIQMFERMIHTGVSFFQRETASTVINAVVFEVNQVLSVLMGVTITLVRDSLTVVFLLGYLFYLNWRLTLIVAILLPCIGWLVGKINRRLRRLNREHQTLTNQLAYIVEETVGGYKVVKVHNGEPYEIGRFNELSRKLRGYSMRMTVSGGLAQPLTQFLASIALAVVLTIAVVQSANDQTTVGGFVAFVTAMLLIISPLKHLMDVNQPLQRGMTAAELIFGLIDEPREPEGGGKPLARASGAIEFSHVSFSYGMSRDGRQTLDDVSFTVAPGEMVALAGPSGSGKTTLVNLLPRFFDPSSGSVRVDGVALPEYSLRDLRNQIAMVSQDVVLFNDTIAANVAYGQAPERDRVEAALRAANLWETVTAMPDGIDTLVGDNGMRLSGGQRQRLAIARAIYKDAPILILDEATSALDSESERHVQAALETLMKGRTTLVIAHRLSTIERADRILVLEGGKIVESGSHRELLEQGGLYAHLHRIQFQQDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W21</accession>
    <name>Q63W21_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526393.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107695.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1072"/>
    <dbReference type="EnsemblBacteria" id="CAH35067">
        <property type="protein sequence ID" value="CAH35067"/>
        <property type="gene ID" value="BPSL1072"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1072"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.487"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECLIAED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="32225" checksum="2B920B9E5730185E" modified="2004-10-25" version="1">MRHSPEALLAFAEAANLGSFSAAARKLGKRQSTVSEAIANLEIDLGVTLFDRSTRQPTLTDAARALLPEVQRVLEASEAIDQVAARLAGGEEARLTLVVSDTYQSSRYEETLAALDRRFPTLEFECQIAEHDDVLDLIQQGRAQLGLMAARSTYPPDIGAATIAERSEIGLYVGPQHALAAYGDAEVPLAALHDTRELRLNTYVAPRGERVETGLVAGRRCWLAPSYLQLLEMAVAGFGWAELPRWMVEHFARERLVELNARGWPRRVPVDAVWSRGQPLGPAGSWLLETMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WC6</accession>
    <name>Q63WC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526300.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107590.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0962"/>
    <dbReference type="EnsemblBacteria" id="CAH34958">
        <property type="protein sequence ID" value="CAH34958"/>
        <property type="gene ID" value="BPSL0962"/>
    </dbReference>
    <dbReference type="GeneID" id="56526871"/>
    <dbReference type="KEGG" id="bps:BPSL0962"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.615"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WREPFER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="13254" checksum="E1446F2234FD859A" modified="2004-10-25" version="1">MNKHGIVLFGHGARDARWAGPFERLAAKLRAARGAEASVVLAFLELMEPSLAAATAALAAQGCDAITVIPVFFGEGGHVRRDLPGLIDACRAAHPGVDIRCATAVGEDDAVLDAIVAYCMRASADPTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WN7</accession>
    <name>PDXH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="1">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PNP/PMP oxidase</fullName>
            <shortName evidence="1">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxH</name>
        <name type="ordered locus">BPSL0854</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH34846" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34846.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522643.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107479.2">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WN7"/>
    <dbReference type="SMR" id="Q63WN7"/>
    <dbReference type="STRING" id="272560.BPSL0854"/>
    <dbReference type="EnsemblBacteria" id="CAH34846">
        <property type="protein sequence ID" value="CAH34846"/>
        <property type="gene ID" value="BPSL0854"/>
    </dbReference>
    <dbReference type="GeneID" id="56526967"/>
    <dbReference type="KEGG" id="bps:BPSL0854"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.744"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PEPNAMV"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167696" description="Pyridoxine/pyridoxamine 5'-phosphate oxidase">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="214" mass="24265" checksum="0BA636558BBAB424" modified="2006-10-31" version="2">MTTLADLRTNYSRASLDAADVNPNPFVQFDVWFKEALDAQLPEPNTMTLATVDESGRPSARIVLIKGADERGFVFFTNYESRKGRELAHNPNAALLFYWIELERQVRVEGRIEKTSEEESDRYFASRPLGSRIGAWASEQSAVIESRALLEAREKEIGARFGENPPRPPHWGGYRLVPSSIEFWQGRPSRLHDRLLYTRDAASASGWKIARLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WS8</accession>
    <name>Q63WS8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RND family acriflavine resistance protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bpeA</name>
        <name evidence="4" type="ordered locus">BPSL0814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197561.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107438.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63WS8"/>
    <dbReference type="STRING" id="272560.BPSL0814"/>
    <dbReference type="EnsemblBacteria" id="CAH34805">
        <property type="protein sequence ID" value="CAH34805"/>
        <property type="gene ID" value="BPSL0814"/>
    </dbReference>
    <dbReference type="GeneID" id="56596551"/>
    <dbReference type="KEGG" id="bps:BPSL0814"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.789"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INVRYTK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="62"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="420" mass="43283" checksum="FB5EBEC2D2107077" modified="2004-10-25" version="1">MRVERVPYRLITVATAAVFLAACGKKESAPPPQTPEVGVVTVQPQPVPVVSELPGRTSAYLVAQVRARVDGIVLRREFTEGSDVKAGQRLYKIDPAPYIAQLNSAKATLAKAQANLATQNALVARYKVLVAANAVSKQQYDDAVAAQGQAAADVGAGKAAVETAQINLGYTDVVSPITGRVGISQVTPGAYVQASQATLMSTVQQLDPVYVDLTQSSLDGLKLRQDIQSGRIKTEGPGAAKVTLILEDGKPYPERGKLQFSDVTVDQTTGSVTIRAIFPNKQRVLLPGMFVRARIEEGVNENAFLVPQIGVTHDPKGQAIAMIVDGKGKVEPRVLVTGGTQGQNWVVESGLQAGDRVIVQGIDKVRPGMTVKAAEAQLPAAAAGASGAAPAGGSPAQAAAASAAASGAAPSSAAAASSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X99</accession>
    <name>Q63X99_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107267.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0638"/>
    <dbReference type="EnsemblBacteria" id="CAH34631">
        <property type="protein sequence ID" value="CAH34631"/>
        <property type="gene ID" value="BPSL0638"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0638"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.693"/>
    <dbReference type="eggNOG" id="COG4395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWDANEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266853" evidence="3">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Tim44" evidence="4">
        <location>
            <begin position="190"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="33635" checksum="2ADBF9C810600232" modified="2004-10-25" version="1">MARRIGTFLMVGLLAAGTFASLDAEAKRMGGGRSVGRQSQSLQQRQATPPAQQPMQQAAPTQAPRQQPMPAAQPNRSRWLGPIAGLAAGLGIAALLSHLGLGGAFAGMMANVIVIALLAMAGIWLVRKFMNRRGAQQPAYAGGQPTLNRGHDGYSQDAGVQRPAAPGGAFPGSGSAYAGEAQRVFGGAAAATAAAAAPAVPAGFDTEAFLRNAKVYFVRLQAAWDEGNLADIREFTTPEMFAEVKIDLDGRGAGANQTDVVQLDAELLAVEDRGGEHLASVRFHGLIRETQGAAAEPFDEVWNLSKSGSQGWLLAGIQQASTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XC8</accession>
    <name>Q63XC8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526106.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107237.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63XC8"/>
    <dbReference type="STRING" id="272560.BPSL0608"/>
    <dbReference type="EnsemblBacteria" id="CAH34601">
        <property type="protein sequence ID" value="CAH34601"/>
        <property type="gene ID" value="BPSL0608"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0608"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1021"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SAWISHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="244" mass="25332" checksum="EBC863EC5075447B" modified="2004-10-25" version="1">MRLLFFLTNFGDPMLTAPLAFAVLSWLAASRRRRAALVWALGFACAVGVVALTKFVYAGWGIGIAAWRFTGVSGHTMLGAAVYPLVAAICVRDAYPRRALAAGLAFALAIGMSRVLLGFHSWSEIVSGWLLGAAVAASTARCLRGIGGARASQAQASGMHAARNVPMARRAHGGGAVGAHPHAAAGAAAVRRAARAPRSTLMFVAAACAIAVSCYGRSAPVSAWISDAAPKVAEWGRVWFDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XI2</accession>
    <name>Q63XI2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL0557A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107183.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0557A"/>
    <dbReference type="EnsemblBacteria" id="CAH34547">
        <property type="protein sequence ID" value="CAH34547"/>
        <property type="gene ID" value="BPSL0557A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0557A"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="68" mass="7852" checksum="56D0B9DD5CCC6AE3" modified="2004-10-25" version="1">MESGARRVQRLPVEKRPPNRERDILFLSRVADLECCHALSGNARDQRFNVAASRARDRMYLVRPVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XN0</accession>
    <name>Q63XN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522867.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107135.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0509"/>
    <dbReference type="EnsemblBacteria" id="CAH34499">
        <property type="protein sequence ID" value="CAH34499"/>
        <property type="gene ID" value="BPSL0509"/>
    </dbReference>
    <dbReference type="GeneID" id="56527245"/>
    <dbReference type="KEGG" id="bps:BPSL0509"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1139"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMRIKGE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="3">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="326" mass="35036" checksum="CAFFAAFB83F703F1" modified="2004-10-25" version="1">MTDSDAHATEPPDHFPCARLIKEIGRGPNGARALPYDDAFALYRAMLDGHVSDVELGAVLIAYRLKGETADELAAMLAAAHASFEPLHVQDAMFRTVSIPSYNGARRQPNLVPLLALLLAREGVPVLVHGVTEDPGRVTSAEIFAELAIAPGSTHDEIEDTLAERRAAFAPIEVLAPKLARLLALRRVLGVRNSTHTIVKLLQPFEPAGLRLVNYTHPPYRDSLVELFRGHPAAAAGGALLARGTEGEAVADTRRQVQVDWLHDGHCETIVEPARASSDAPPVELPASRDAATTAAWTDSVMRGEIPVPDAIAMQVDTIVRLARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XS4</accession>
    <name>Q63XS4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543739.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107091.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0465"/>
    <dbReference type="EnsemblBacteria" id="CAH34454">
        <property type="protein sequence ID" value="CAH34454"/>
        <property type="gene ID" value="BPSL0465"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0465"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1191"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYSHYDE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17200">
        <property type="entry name" value="sCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="270"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="546" mass="57086" checksum="0489FDB7B5DC11DB" modified="2004-10-25" version="1">MNRMSLNRKLWLALALVWVGLLGVGAWSAFETRTTMLAERKEGMANLVDSAAGVVKAYYALAQSGKMSDEDARRDALERIAAMRYGDSGYLFVMDSKPVVLMHPTLPKLVGTQVGDYLDPDGKRLFVTILNAAKAGGHGFAEYRGRLPHSETAVPKISYVTRFAPWDWNISSGVFLKDIDTVYYETLVGHLAVVFVIGLVITAAMLVIIRNVRASLGGEPDEAASLAARIAAGDLTRPVAVRAGDGTSMMAAMRDMQGRLRSTIGGIRRAAESIAAASHEIASGNHDLSQRTEQQAASLEETAASMEELTATVKQNAENARQASGLANNASEIALKGNDVVSRVIGTMGEINDSSRKIADIIGVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRSLAQRSATAAKEIKQLIDASVERVNNGSALVGQAGETMTEILQAVRRVTDIMGEIAAASEEQSSGISQVGRAVTQMDEMTQQNAALVEEAAAAASSLQEQAARLRESVSAFQVGDGAAAGAGAAAGVVGGPNAAASSGCVEPALA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU7</accession>
    <name>GPMA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-dependent PGAM</shortName>
            <shortName evidence="1">PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">dPGM</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA</name>
        <name type="ordered locus">BPSL0443</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198007.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107068.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XU7"/>
    <dbReference type="SMR" id="Q63XU7"/>
    <dbReference type="STRING" id="272560.BPSL0443"/>
    <dbReference type="EnsemblBacteria" id="CAH34431">
        <property type="protein sequence ID" value="CAH34431"/>
        <property type="gene ID" value="BPSL0443"/>
    </dbReference>
    <dbReference type="GeneID" id="56594472"/>
    <dbReference type="KEGG" id="bps:BPSL0443"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1215"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q63XU7"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229112" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <sequence length="249" mass="27893" checksum="E51933D372E4896E" modified="2004-10-25" version="1">MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGNREARQAGQLLKEAGYTFDIAYTSVLKRAIRTLWHVQDQMDLMYVPVVHSWRLNERHYGALSGLNKAETAAKYGDEQVLVWRRSYDTPPPALEPGDERAPYADPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVKAGKQVLIAAHGNSLRALIKYLDGISDADIVGLNIPNGVPLVYELDESLTPIRHYYLGDQEAIAKAQAAVAQQGKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XX1</accession>
    <name>Q63XX1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536383.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107044.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0419"/>
    <dbReference type="EnsemblBacteria" id="CAH34407">
        <property type="protein sequence ID" value="CAH34407"/>
        <property type="gene ID" value="BPSL0419"/>
    </dbReference>
    <dbReference type="GeneID" id="56527337"/>
    <dbReference type="KEGG" id="bps:BPSL0419"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1243"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPLFWKP"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="10">
        <location>
            <begin position="305"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="485"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="614"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="708" mass="75143" checksum="C44E834CB34EA45D" modified="2004-10-25" version="1">MNQQAFPATGTVTRERRDKVLVVTIDHPPVNALSADVRRGLVDALDAADADAAVGAVLIVGAGRNFIAGADIREFGKLPVPPLLPDVCNRIETSGKPVVVALHGAALGGGLEVALAAHYRLAVPGAKLGLPEVQLGLLPGAGGTQRTPRLIGAKAALELMLSGRHASAEEALALGLVDRLAHSDDTLAEGLAYVHELLAAGAGVRRTRDAQGLADRAAAEAALDAARADVARHSRGLFSPARIVDAVAAALAQPFDEGLRTERRLFVECLDSPQRAGLVHAFFAQREAAKSPETRRGAPRAIERIGVVGGGTMGAGIAVAALDAGFPVTMIERDDASLERGRAHVEKVYAGLVAKGRMTPAAQAARLARFKGGTSYEALAQADVVIEAVFEDMAVKKAVFAELARACKPGAVLATNTSYLDIDELAASVERAPDVIGLHFFSPANIMKLLEVVVPAKVSADVVATAFELARKLGKIPVRAGVCDGFIGNRVLAVYRTAADYMMEDGASPYQIDRAIREFGFPMGPYQVVDLAGGDIGWATRKRRAPTRDPRLRYVEIGDRLCERGWFGQKTGRGYYLYPDGARVGTPDPEVEAIIAQARAAKGVSPRAFTDEEIVRRYLAAMINEGANVVHEKIALRPLDVDAVFLHGYGFPRHRGGPMHYADTVGLANVLADIRAFAGEDPVFWKPSPLLVDLVARGETFASLNRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XZ6</accession>
    <name>Q63XZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536367.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107019.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0393"/>
    <dbReference type="EnsemblBacteria" id="CAH34381">
        <property type="protein sequence ID" value="CAH34381"/>
        <property type="gene ID" value="BPSL0393"/>
    </dbReference>
    <dbReference type="GeneID" id="56527363"/>
    <dbReference type="KEGG" id="bps:BPSL0393"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1273"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVYRADS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="414" mass="44908" checksum="881859E5D6BEBF31" modified="2004-10-25" version="1">MRLALVLMGGGARAAYQAGVLKGLAEIAHDVDPKRRTSPFSVICGSSAGAINATSLASHADDFEHGVRRLLEFWEQLRAERVYRTDWLGIAAAGARWLAAMSIGWAARRSPRGLLDNAPLAYLLRRELDFHRIELMLEARKLHALSVTALSYSSGRHLTFYQASEPIQAWRRAERTARMVDLSAEHLLASSAIPFVFPAVPLVLDGQIEYFGDGSIRQIAPLSPAIHFGSDRIVVVGAADPRPEVPAANGNGRGYPSLAQIGQQVLASVFLDSIGADIERIDHVNRMIEHLPAYVEPESGWRHVDVLAIAPSERIELIASKHLKRLPLTVRGLLGAVGGNKPAGASFASYLLFEAEFTRELVELGYRDAHGQRERLAQWIASAEHRGGPAERGPGAGTDARTGAGAHAARRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y11</accession>
    <name>Q63Y11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107004.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0378"/>
    <dbReference type="EnsemblBacteria" id="CAH34366">
        <property type="protein sequence ID" value="CAH34366"/>
        <property type="gene ID" value="BPSL0378"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0378"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.426"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVSRHYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="17223" checksum="429C2B77F410B3EA" modified="2004-10-25" version="1">MLVVDKRFQRLPMSDAPMRLPCHCGTLRQATRAITSLYDAHLARHGIRITQFTILAALHGGDALPTGELATRLLLDQTTLSRTLATLQSNQLVRAESGDDQRVRLWSLTPKGTALFKAARVDWEAAQNDVYRRIGKRNMQALDADIFALAKALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y73</accession>
    <name>Q63Y73_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FolB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199336.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106942.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63Y73"/>
    <dbReference type="STRING" id="272560.BPSL0315"/>
    <dbReference type="EnsemblBacteria" id="CAH34304">
        <property type="protein sequence ID" value="CAH34304"/>
        <property type="gene ID" value="BPSL0315"/>
    </dbReference>
    <dbReference type="GeneID" id="56594649"/>
    <dbReference type="GeneID" id="66548476"/>
    <dbReference type="KEGG" id="bps:BPSL0315"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1372"/>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INIGVHD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006760">
        <property type="term" value="P:folic acid-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="4">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="134" mass="15225" checksum="8BD7EF0FD95B9661" modified="2004-10-25" version="1">MFAALLHPRLADCRRLYLRNHEVYMNIGAFEHEKRGEQRVVINVDLFVPLALTTPVEDRLREVVDYDLMKQSVAQCVARGHIHLQETLCDAIAASLLAHDAVRAVRVSTEKPDAYPDCDAVGVEVFRIKDEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YE6</accession>
    <name>Q63YE6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE type translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534257.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106869.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0242"/>
    <dbReference type="EnsemblBacteria" id="CAH34230">
        <property type="protein sequence ID" value="CAH34230"/>
        <property type="gene ID" value="BPSL0242"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0242"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1470"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIWRSAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="217" mass="22896" checksum="730ABE1D5978EC36" modified="2004-10-25" version="1">MNLLPILLQIAAVYLLALVTPGPNIFMISQLSLSGRRGLGAVSALGVGTASLTWATLAMLGVAAVLHQLAWLYEAIRIGGAVYLAYFGIKLLRASAQRDPAPAAGLADDAGALPSPPATRDYLRAYRTGLFTCLTNPKSCVFWTSVFAAMMPAHVPLWFSGATLLTIGAMSGGWYCGVAYLFANPRAQRGYRRVRRPLDALCGAALVGLGAKLAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YV8</accession>
    <name>Q63YV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">intA</name>
        <name evidence="9" type="ordered locus">BPSL0081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525821.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106707.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0081"/>
    <dbReference type="EnsemblBacteria" id="CAH34065">
        <property type="protein sequence ID" value="CAH34065"/>
        <property type="gene ID" value="BPSL0081"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0081"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1652"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALCVRKM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="102"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="206"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="409" mass="45974" checksum="251BC50F59B6ABAB" modified="2004-10-25" version="1">MPKISTPLNDTRIKALKPKAARYTVSDGGGLVLEVMTSGSKFWRYRYSLHGKQQPVVTIGEYPAVSLTAARERARRYAEIVAGGVSPVADARKDRGAVKSLDTIHEFAEYWIEQQMMGKSAEYLRTTRRALEKDIYPAIGGKSVSDVTPGDVLAICDRIKKRGAPKMALSTRNILKRIYEYAIARQLVTSNPAQAIVARFVATQASRDRVLSPNEIGRVLRAVYASSIRRPLKLAIHLLVLTMVRKSELIEARWDEFDLDASIWRIPAERMKKDREHWVYLAPQAVAMLRELHATRTSHQYVFPSSRGADRPIAKSTLNQAVRALDMDVQHFVLHDFRRTASTHLHEMGQPSDAIEKALAHSIKGIKGVYNRAEYADERRRITALWADFVDAQIDEGRKVVIGKFGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YY1</accession>
    <name>Q63YY1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PaaX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202847.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106684.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0059"/>
    <dbReference type="EnsemblBacteria" id="CAH34042">
        <property type="protein sequence ID" value="CAH34042"/>
        <property type="gene ID" value="BPSL0059"/>
    </dbReference>
    <dbReference type="GeneID" id="56594149"/>
    <dbReference type="KEGG" id="bps:BPSL0059"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1682"/>
    <dbReference type="eggNOG" id="COG3327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HQWREDE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX_C" evidence="1">
        <location>
            <begin position="167"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="30716" checksum="F515E0D6CF8D7A5E" modified="2004-10-25" version="1">MTQPTARHLILDLLVAKDGEPLQVREAIIACRLFGLTENSVRVALARLAAESLVEGAERGSYRLGPSAVELSEELTAWRTVESRLRRWSGAYLMVSCISLGRVDRTALARRERALEMLGFREWDKSLYVRPDNIAGNVDSVRRRLTKLGVEPAAAVFVAMGFDAPQEARIRALWDGDALSDTYRTLGAQLEDWLARAPELDLDVAAREAFLLGGKAIRQVVFDPLLPEPFVDVAARAAFIECARRYVGAGHRIWRALLDSEHPSAPGAARDAIVGHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z03</accession>
    <name>Q63Z03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ATP-binding ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199877.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106662.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0037"/>
    <dbReference type="EnsemblBacteria" id="CAH34020">
        <property type="protein sequence ID" value="CAH34020"/>
        <property type="gene ID" value="BPSL0037"/>
    </dbReference>
    <dbReference type="GeneID" id="56594123"/>
    <dbReference type="KEGG" id="bps:BPSL0037"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1709"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTVMHEE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="29638" checksum="4138AA25D5E038B4" modified="2004-10-25" version="1">MNPHVSAHAPAIEFRNVSCRFISPDGRATVALHDFTMSVARGEFVAVVGPTGCGKSTTLNLITGLLKPVSGEVRVMGKPVDGIDPRIGFVFQADAVFPWRTVIDNVAAGPLFRGRSKESAYAQAEEWIRRVGLAKFAKHYPHQLSGGMRKRVALAQTFINQPEILLMDEPFSALDMQTRTLMQDELLQLWSANKGSVVFVTHDLEEAIALADRVFVLTSRPATLKRVYEIDLPRPRVTSEVRYEPRFIEISKDIWHDLREEVQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I06</accession>
    <name>Q63I06_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529471.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112266.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2263"/>
    <dbReference type="EnsemblBacteria" id="CAH39749">
        <property type="protein sequence ID" value="CAH39749"/>
        <property type="gene ID" value="BPSS2263"/>
    </dbReference>
    <dbReference type="GeneID" id="56598371"/>
    <dbReference type="KEGG" id="bps:BPSS2263"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5867"/>
    <dbReference type="OMA" id="HEIRVWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="81" mass="9289" checksum="A11AEE038FF1C7D6" modified="2004-10-25" version="1">MEPNARTMYEYGGYEIRVWASRNERGAWVSDVEIYRDGRRVLAAVPETVSPEWGTEEECVRDAIGQGRDLIDRGDVARCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IA1</accession>
    <name>Q63IA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187860.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112171.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2170"/>
    <dbReference type="EnsemblBacteria" id="CAH39654">
        <property type="protein sequence ID" value="CAH39654"/>
        <property type="gene ID" value="BPSS2170"/>
    </dbReference>
    <dbReference type="GeneID" id="56598340"/>
    <dbReference type="KEGG" id="bps:BPSS2170"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5746"/>
    <dbReference type="eggNOG" id="COG3805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWSCQLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="PTHR36423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028139">
        <property type="entry name" value="DOPA-diox_rel_Mll2280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="SSF143410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="117" mass="13285" checksum="361DBEF9B21F7B80" modified="2004-10-25" version="1">MTSSDIATITGWHAHVYFDASSRDAAWAFRETIERRFGASVQLGRFHERLVGPHPTWSYQIAFEPTQFADVVPWLVLHHGALDVFLHPNTGDELRDHRDAAAWIGRSYTLNLDALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE2</accession>
    <name>Q63IE2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HNS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190530.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112130.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2131"/>
    <dbReference type="EnsemblBacteria" id="CAH39612">
        <property type="protein sequence ID" value="CAH39612"/>
        <property type="gene ID" value="BPSS2131"/>
    </dbReference>
    <dbReference type="GeneID" id="56598155"/>
    <dbReference type="KEGG" id="bps:BPSS2131"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5691"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALPPKYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="6">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10983" checksum="B9D8975C8B442FE6" modified="2004-10-25" version="1">MATYRQLTAQLEKLQQKIDKEREKAITDAIADIKAKIEEYDITPEELGFRSVKAAAKPKRALPPKYLNPKTGETWSGRGRAPAWLGKNRNRFLIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF2</accession>
    <name>Q63IF2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552205.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112120.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2121"/>
    <dbReference type="EnsemblBacteria" id="CAH39602">
        <property type="protein sequence ID" value="CAH39602"/>
        <property type="gene ID" value="BPSS2121"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2121"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5670"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANFSFEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="4"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="373" mass="39024" checksum="6A53F269F6A34465" modified="2004-10-25" version="1">MTHIYLDYNASTPIDPAVADAMRPLLPEAFGNPSSGHWASVPAKVALDRARAQVATLIGAAPDEIVFTSGGSEANNLALKGTVLASSNAGGHVITQSTEHPAILKPLQFLERLGTEVTCVPVDGNGRVDPDAIRRAITPRTTLITVMHANNETGTIQPIEDIGTIAREHGIRFHTDAAQSIGKIPADVDALGVDLLSIAGHKLYAPKGIGALYVRKGVGLEPLIHGAGHENGRRAGTESALLAAGFGEACALARDLAAMDGIRALRDRLWHALQDRFDDRVRLNGHLEYRLPNTVNVSFVGRVGADVLAALDGVAASTGSACHAGRMTLSPVLAAMGIAEQVGMGAIRFSLGRHTTADEIDTVIAKLSAIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IH3</accession>
    <name>Q63IH3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524810.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112099.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2100"/>
    <dbReference type="EnsemblBacteria" id="CAH39580">
        <property type="protein sequence ID" value="CAH39580"/>
        <property type="gene ID" value="BPSS2100"/>
    </dbReference>
    <dbReference type="GeneID" id="56531806"/>
    <dbReference type="KEGG" id="bps:BPSS2100"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5643"/>
    <dbReference type="eggNOG" id="COG3516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMGGNDK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008312">
        <property type="entry name" value="T6SS_TssB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35850">
        <property type="entry name" value="PTHR35850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05591">
        <property type="entry name" value="T6SS_VipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028301">
        <property type="entry name" value="UCP028301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03358">
        <property type="entry name" value="VI_chp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="192" mass="21171" checksum="45AD56966FFB9199" modified="2004-10-25" version="1">MTSKYKASASGQKFIARNRAPRVQIEYDVETYGAERKVQLPFVMGVIADLAGKRAEPLPDLPERKFLEIDVDNFDERMKSIAPRVAFQVPNTLSGDGMLSVDMTFESIDDFSPAAIARNVDALRRLLDARTELSNLLSYMDGKHGAEQLIENAINDPALLASLVRQPLAADAEGGARQPVTGTEDDPEIRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J01</accession>
    <name>Q63J01_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555126.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111921.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1915"/>
    <dbReference type="EnsemblBacteria" id="CAH39393">
        <property type="protein sequence ID" value="CAH39393"/>
        <property type="gene ID" value="BPSS1915"/>
    </dbReference>
    <dbReference type="GeneID" id="56529667"/>
    <dbReference type="KEGG" id="bps:BPSS1915"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5390"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="247"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="459" mass="50050" checksum="299E8092D3504717" modified="2004-10-25" version="1">MKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGTKKLRLRNWSPLPVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIMLIDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRLLPAGHILGAASVVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVFAKTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMATSVTEIYRRRLSDHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVIIAGSGMATGGRVLHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHADYGEILGWLGAQSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J96</accession>
    <name>Q63J96_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525095.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111826.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1822"/>
    <dbReference type="EnsemblBacteria" id="CAH39298">
        <property type="protein sequence ID" value="CAH39298"/>
        <property type="gene ID" value="BPSS1822"/>
    </dbReference>
    <dbReference type="GeneID" id="56529762"/>
    <dbReference type="KEGG" id="bps:BPSS1822"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6148"/>
    <dbReference type="eggNOG" id="COG3687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHDNRHH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="35118" checksum="FFE242D5F4B2B3BB" modified="2004-10-25" version="1">MNQPAKSTDPVSVMPVRRDLRFNLPVERATDWHGQGSQVSHFFNALSLLFPAGERFFMDSVRNYRDRIDDPVLKKQVLGFIGQEAMHTREHVEYNELMHANRLPARTVDRRVWKVTGWMKKVLPHSVQLAHTVAAEHYTAMLANWLLSEPAALAGSHEGYKQMWLWHALEETEHKAVSFDVWNTVMKPGPKRYLIRIGVYLLTTMTFWPNVFLIHSQLIRWDRKSDKSVRGLWRVVSLLYGPRHGMFPAIAREWLSFFRPDFHPWDYDNHHHLARVDAIVEATQAREARKLAAVELDGAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH2</accession>
    <name>Q63JH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome b561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190603.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111750.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1744"/>
    <dbReference type="EnsemblBacteria" id="CAH39219">
        <property type="protein sequence ID" value="CAH39219"/>
        <property type="gene ID" value="BPSS1744"/>
    </dbReference>
    <dbReference type="GeneID" id="56598098"/>
    <dbReference type="KEGG" id="bps:BPSS1744"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5171"/>
    <dbReference type="eggNOG" id="COG3038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FIKGWHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="178" mass="19942" checksum="32487C1FF324A2AD" modified="2004-10-25" version="1">MNRILAGQERYNRPAVFFHWAIFLLVALAYLAIEVRGPKGTDSRVFWSNVHYLAGSLVLALAVLRIVWRFAGGAPRELPQPAWLALFAKLAHLALYAFIVAQPLLGIMTLNFGGKPVTLAGIDWSFTLFAPNAALRSTVKEAHELIGNVFYYVIGLHALAALWHHFVKRDATLRRMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP0</accession>
    <name>Q63JP0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187318.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111682.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1677"/>
    <dbReference type="EnsemblBacteria" id="CAH39150">
        <property type="protein sequence ID" value="CAH39150"/>
        <property type="gene ID" value="BPSS1677"/>
    </dbReference>
    <dbReference type="GeneID" id="56598030"/>
    <dbReference type="KEGG" id="bps:BPSS1677"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5082"/>
    <dbReference type="eggNOG" id="ENOG50330K4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAELAQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="77" mass="8784" checksum="1D26E8DC4D9FAB81" modified="2004-10-25" version="1">MTTHRFDVFGRQILVERTGGRWVPFYPGADGKRRPAHFVIPDFLEADELGQYLGDLFHESATPDNGDVKRLDLPEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP1</accession>
    <name>Q63JP1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551979.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111681.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39149">
        <property type="protein sequence ID" value="CAH39149"/>
        <property type="gene ID" value="BPSS1676"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1676"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5081"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DAVGMYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="36489" checksum="FE80A47CCF6773A1" modified="2004-10-25" version="1">MTDTPRFRNPIRSEVDLDANGKHAGYLRVPHSVHRSAYGWIPVPIVSIRNGSGPVVLVMAGNHGDEYEGQIVVSRIVREIDAPHVRGQLIFLPMANFPAADAGTRVSPIDGGNLNRSFPGDPAGVPTAVIADYIEHTLLPRAQYLIDLHSGGSSLLYQGGNLLALEPRDAAERARVRALLAAFGLPRAFLHAPNPVHASSAARRQGALSILTELGGGGMSDPALIRDARRGLLHFLGFVGALRGPLVPDSPPATTRFMRVSGAHHYVYAYDKGLYEPLVELGARVRAGQPAALIHFPDTPLREPVTQCFASDGEVVCKRVPAQVQRGDCLFQLAEDDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP9</accession>
    <name>Q63JP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Formate dehydrogenase-O, major subunit</fullName>
            <ecNumber evidence="12">1.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fdoG</name>
        <name evidence="12" type="ordered locus">BPSS1667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.2" evidence="12"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1667"/>
    <dbReference type="EnsemblBacteria" id="CAH39141">
        <property type="protein sequence ID" value="CAH39141"/>
        <property type="gene ID" value="BPSS1667"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1667"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KWDGAKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047111">
        <property type="term" value="F:formate dehydrogenase (cytochrome-c-553) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006443">
        <property type="entry name" value="Formate-DH-alph_fdnG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01553">
        <property type="entry name" value="formate-DH-alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266334" evidence="10">
        <location>
            <begin position="35"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113325" checksum="76F7FD57A711BEC5" modified="2004-10-25" version="1">MLQLSRRQFLKLSATTLAGSSLALMGFSPAEALAEVRQYKLARTVETRNTCPYCSVGCGILMYGLGDGAKNATSSIVHIEGDPDHPVNRGTLCPKGASLIDFIHSPSRLTQPEYRAAGSDKWQPISWSDALDRIAKLMKADRDANFVETTDDGMKVNRWLTTGMLAASAGSNEVGYLTHKTVRSMGMLAFDNQARVHGPTVAGLAPTFGRGAMTNHWVDIKNADVILVMGGNAAEAHPCGFKWVTEAKAHRNARLVVVDPRFTRTASVADYYAPIRTGTDIAFLGGVIHYLLTNDKIQHEYVKHYTDFSFIVREDFAFDDGIYSGYDADKHAYPDKSTWDYERGDDGFVKVDETLAHPRCVYNLLKQHYARYTPEMVEKICGTPKDKFLKVCEMLATTAVPGRAGTVLYALGWTHHSVGAQMIRTGAMVQLLLGNIGIAGGGMNALRGHSNIQGLTDLGLMSNLLPGYMTLPMQAEQDFDAYIQKRAQQPLRPNQLSYWKNYRAFHVSFMKAWWGDAASAENNWGYDYLPKLDKQYDLLQTIELMHAGKMNGYICQGFNPLAAAPSKRKTSEALAKLKWLVIMDPLATETSEFWKNHGEFNDVDSSKIQTEVFRLPTSCFAEERGSLVNSGRVLQWHWQGAEPPGQAKSDLEIMSGIFLRMRDMYRKDGGKYPDPIVNLSWPYANPESPTPEELAMEFNGRALADLPDPKDPTKTLVKKGEQLAGFAQLKDDGTTASGCWIFCGAWTQAGNQMARRDNADPTGIGQTLNWAWAWPANRRILYNRASCDVNGKPFDPSRKLIGWNGKTWTGADVPDYKLDEPPETGMGPFIMNPEGVARFFARAGMNEGPFPEHYEPFETPLAANPLHPGNPRALNNPAARVFPDDRASFGKVDQFPHVATTYRLTEHFHYWTKHARLNAIVQPQQFVEIGEDLAKEIGVAHGEQVKVSSNRGHIVAVALVTKRIKPLMVDGRKVQTVGVPLHWGFKGLTKPGYLANTLTPSVGDGNSQTPEFKSFLVKVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JS5</accession>
    <name>Q63JS5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative citrate lyase beta chain</fullName>
            <ecNumber evidence="6">4.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.3.6" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551952.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111647.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1639"/>
    <dbReference type="EnsemblBacteria" id="CAH39114">
        <property type="protein sequence ID" value="CAH39114"/>
        <property type="gene ID" value="BPSS1639"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1639"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5031"/>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLNEGDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008815">
        <property type="term" value="F:citrate (pro-3S)-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="293" mass="30439" checksum="3BA1C1B264EA452E" modified="2004-10-25" version="1">MSISIPHDAAAPAACDRLHSALRSWLFTPATRADRFSNASECGADVLIVDLEDSVAPADKAYARDHARAWLSSGQAHARPASAVRINAPDTVAGHADLGMLIDAPRAPDFIVVPKVETQQRIAHLDALLRDAGRLPRYGFVAMIESAAGADAADAIVRACGSIGALMFGAADYASDVAAQPDALALQIARVRLAAACARGRIAAIDAPCFALRDAAALDTELAFAVRNGLRGKAAIHPAHVAPINAAFAPSPQRIAWARRVIGAASQGAAVVDGRMVDEAVAREARDVLAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JY8</accession>
    <name>Q63JY8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537224.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111584.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1578"/>
    <dbReference type="EnsemblBacteria" id="CAH39051">
        <property type="protein sequence ID" value="CAH39051"/>
        <property type="gene ID" value="BPSS1578"/>
    </dbReference>
    <dbReference type="GeneID" id="56530011"/>
    <dbReference type="KEGG" id="bps:BPSS1578"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4952"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HFGVPLH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017746">
        <property type="entry name" value="Cellulose_synthase_operon_BcsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06564">
        <property type="entry name" value="CBP_BcsQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03371">
        <property type="entry name" value="cellulose_yhjQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="287" mass="29307" checksum="2475A62906F6446C" modified="2004-10-25" version="1">MKTIAIVSTTGGAGRTMLTAALAALLARDGRPVVALDFDPQNLLGVQLGLDAFAPAGIAHALAGAHAAWHAHTWRSADGVLFVPYGHVDPAQALACDARLAADPEWLARALADIDLPADGVTLIDTARFPSQQAAHALRCADLALCVVPPEPAACATAAARLPELRAAGVCAGVCSGSGAGTRASIHASTGTSTGAGALHIVVNRLNPARDMQRDVLAMLRAATGPGVVLEQRVHLDAALPEALARGTWFFDDAPHSQASHDLHGVAGWVGAWLDTQAARNAAGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K77</accession>
    <name>Q63K77_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533161.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111495.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1488"/>
    <dbReference type="EnsemblBacteria" id="CAH38961">
        <property type="protein sequence ID" value="CAH38961"/>
        <property type="gene ID" value="BPSS1488"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1488"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4831"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GLVWEWT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267295" evidence="1">
        <location>
            <begin position="38"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="30182" checksum="11D3BB4FDF20156E" modified="2004-10-25" version="1">MHAPSFRHACRAASAVRLARVAIVALTLAFAATGAHAARFVRLPGGDFESALPQDVPGRSTPVHIDAFELQDTPVTVRAFAGFLRAHPEWRRDRVAHVFAGPAYLADWADPLHPASPTPPDAPVTGVSWFAARAYCASEGARLPTWLEWEYAAAADATRPDARNDPLWRRQILSWYEQPAARVLPSVGGAPNVYGLRNLHGLIWEWVDDFNALFISGDSRTQGDPDQQRFCGAGAISIVRRDSYAVLMRVALLSSLTGADSTGSLGFRCARSISGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KJ4</accession>
    <name>Q63KJ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sarcosine oxidase alpha subunit</fullName>
            <ecNumber evidence="7">1.5.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">soxA</name>
        <name evidence="7" type="ordered locus">BPSS1367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="7"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524300.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111378.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1367"/>
    <dbReference type="EnsemblBacteria" id="CAH38839">
        <property type="protein sequence ID" value="CAH38839"/>
        <property type="gene ID" value="BPSS1367"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1367"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4681"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKYSRPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006277">
        <property type="entry name" value="Sarcosine_oxidase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037980">
        <property type="entry name" value="SoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01372">
        <property type="entry name" value="soxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="170"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="SO_alpha_A3" evidence="6">
        <location>
            <begin position="516"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="614"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="5">
        <location>
            <begin position="904"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1002" mass="107911" checksum="79CDC384076349BA" modified="2004-10-25" version="1">MSQKDRLGAGGRINRAQPLTFTFNGRTYQGFQGDTLASALLANGVHFVARSFKYHRPRGIVTAGVDEPNAVVQLETGAYTVPNARATEVELYQGLVATSVNAKPSLEHDRMAVMQKLARFLPAGFYYKTFMWPRNLWPKYEEKIREAAGLGKAPDTLDADRYDKCYAHCDVLVVGGGPTGLAAAHAAAVNGARVILVDDQRELGGSLLACRAEIDGKPALQWVEKIEAELAKLPDMSILTRSTAFGYQDHNLVTVVQRLTDHLPVSMRKGTREMIWKVRAKRVILATGAHERPLVFGNNDLPGVMTASAVSAYIHRYGVLPGRVAVVATNNDRGYQCALDLKACGAKVTVVDARASTRGALPAVAKRHGITVMSGAAVSAAAGKLRVASVDVVSYANGRSGGKIATLPCDLVAMSGGFSPVLHLFAQSGGKAHWNDDKACFVPGKPVQAEASVGAAAGEFELARALRLALDAGVAAAKSAGFAAERPPVPKLAEAVEDALLPLWLASGAEAAVRGPKQFVDFQNDVGAADILLAAREGFESVEHVKRYTAMGFGTDQGKLGNINGMAILAQALGKTIPETGTTTFRPNYTPVSFGAFAGRELGDFLDPIRKTCVHEWHVEHGAMFEDVGNWKRPWYFPRNGEDLHAAVKRECLAVRNGVGMLDASTLGKIDIQGPDAVKLLNWVYTNPWNKLEVGKCRYGLMLDENGMVFDDGVTVRLGDQHFMMTTTTGGAARVLTWLERWLQTEWPDMKVRLSSVTDHWATFAVVGPKSRRVVQKVCKDIDFANDAFPFMSYRDGTVAGVKSRVMRISFSGELAYEVNVPANAGRAVWEALMDAGAEFDITPYGTETMHVLRAEKGYIIVGQDTDGSITPFDLGMGGLVAKSKDFLGRRSLTRADTAKSGRKQFVGLLTDDAQSVLPEGGQIVELDAAARADGTTPMLGHVTSSYYSPILNRSIALAVVKGGLSRMGERVAVSLANGRRVAATISSPVFYDTEGVRQHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KN0</accession>
    <name>Q63KN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphatase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205594.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111341.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1331"/>
    <dbReference type="EnsemblBacteria" id="CAH38802">
        <property type="protein sequence ID" value="CAH38802"/>
        <property type="gene ID" value="BPSS1331"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1331"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4629"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSIFTNH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266117" evidence="2">
        <location>
            <begin position="24"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="147"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="491" mass="51626" checksum="1AC4688C7A4F50D8" modified="2004-10-25" version="1">MPRPILRAAALSLTLAGAALFHACTSSVDNQPDAASAPANIQAAWVEIGDANQAIARVITNYAPPPAAPGEPAPAVCPQLNADGKIARMTLRVAAGTAAQRPTASDPADSKPSSFPVSVCETTLPANAKDVSVASRALPLPKAEPQRVAIVADTGCRMKKADNAFQACSDATVWPFATIAASIAKLNPDLVLHVGDYHYRENACPPDIAGCRNSPWGYGWDAWRADLFEPAAPLLAKAPWIVVRGNHEECARAGQGWFRFLDPRPYSDARSCNDAANDDNANYSEPYAVPLGTGSQVIVFDTAKVGRAALKTTDTQFQLYQKQFQTVAALASKPGMSTTIFTNHHPILAFAPIPGSTPAPGNLALQSVMSSLYAQAYYPPGVQVALHGHVHDFQAINFASGHPATIVSGNGGDNLDVALPDPFPANLTPAPGVVIDKLSHNNSFGFLIMERRAAPARGWTFKAYTAAGKLLASCDQAGATLTCDKTGFVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KX3</accession>
    <name>Q63KX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsI</name>
        <name evidence="4" type="ordered locus">BPSS1240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551741.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111248.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1240"/>
    <dbReference type="EnsemblBacteria" id="CAH38707">
        <property type="protein sequence ID" value="CAH38707"/>
        <property type="gene ID" value="BPSS1240"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1240"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4492"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVMESKT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="68"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="255"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="570" mass="60658" checksum="7E8FFD9B990999E6" modified="2004-10-25" version="1">MPKPAEPLHRRPPLTPAALPRWRSRCVLALLCAGFGALAARALWVQVVRSDFYITQGIKRYGHTFEAAPARGRIVDRNGAELAIDEPVADVWIAPDAFRRATHAQMRALASLLGVPIDTLAAKALGTRQFLYLKRWIAPELAARIERLAVPGVHVAAATRRYYPSGGDAAQLVGFVGADGHGLEGVERTADVALAGVGAKRDMIVDRMGRPVQAGDAASAGVPGADVRLSIDRRIQHLAQRAVERAVARTAAAAGCAIVVDAKTGEILALVNAPTFDPNERTAADDDGRLRERVLTDVFEPASTLKPVTVALALSEGVVAPDTRIDTSPGVLDIEGATIHDTGDFGELTVTQIIAKSSNIGMAKIAERLRAQDMWRTFARAGIGARPLAGLPAVARGTLRPARSWKPIERLTMSYGYGLSVSLAQLADVYTAFAGDGSRIPLSLVHAGALAARVRVVPPAVARQIRAMLETDGEEGTARIARLPDYRIGAKTGTARKLCGKRYARGKYRALFVGLAPMSDPRLIVAVMIDEPSRGSYYGGPAAGPAWAEIMDNALHLLGVPPDRPAARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KY2</accession>
    <name>Q63KY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184771.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111239.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1231"/>
    <dbReference type="EnsemblBacteria" id="CAH38698">
        <property type="protein sequence ID" value="CAH38698"/>
        <property type="gene ID" value="BPSS1231"/>
    </dbReference>
    <dbReference type="GeneID" id="56597450"/>
    <dbReference type="KEGG" id="bps:BPSS1231"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4480"/>
    <dbReference type="eggNOG" id="ENOG5032QUS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLHWGEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="51"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="156" mass="16984" checksum="475E10FB3C79DFFC" modified="2004-10-25" version="1">MKQAGIRIGTHAIALALGFALGIYALPILTAERGASETELRPVADRALYTGRFERSLTRGDPLHWTDGKLSVTRAALAFEGRVAPGPDYKLYLVPGFVASKEAFLAAKPHARRVGELKTFGDFVAPLAADVDIDAYTTVVIWCERFSQFIGAAQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L14</accession>
    <name>Q63L14_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111207.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1197"/>
    <dbReference type="EnsemblBacteria" id="CAH38664">
        <property type="protein sequence ID" value="CAH38664"/>
        <property type="gene ID" value="BPSS1197"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1197"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5365"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WATGMIE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="943"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2617"/>
            <end position="2691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1594"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="3154" mass="328270" checksum="00B8840F7D2E800E" modified="2004-10-25" version="1">MPRPPMNTDNPRRAEPIAIVGMGCVFPGAAGPAAFLELLRAGRVAVRDVPPERWDAAALHDPDPDAPGRILTRRAATIDGAHGFDPEFFGLSRRDAREMDPRQRLMLKTAWWALEDAGMPGWGLAGRSVGVFLGASNGEFGGAHARLSAIGASTAAGHATSVLANRVSYLLGLTGPSLVVDTACSSSLVAVHLACAALRARECELAIAGGVSLMLRPDASVAFSRARMLAADGRSKPFSASADGYGRGEGAGAVVLKRLSDARRDGDRIVAIVLGSAVNHNGQSNGITAPSAPAQEALIRQAIEAAGVAPEQIDLVEAHGTGTLLGDPLEAKALGRVLGAIDGRAGALPIGSVKGNIGHLEAAAGIAGLIKLALALRHREILASAGFDAPNPHIDFRALNLTVPTARTPLPERARPAIGALSSFGFGGANAHLIAAAPPADQPDRHDRHDQHDSPVRHAGAQTGAPWPALLVLSAASDSALNRLAAATAACARGDRPGAWRLARASHVARSPLRRRLAVVAPDADTLAAALDRAASGGRDGVVARGAAPRRRPALAFLYAGQGAQFPGMAAGLLDGDTELRRTLEHASAITGLPIVDWLAAGGAALDRTDVTQPLMVALQVGLTRQWAAWGVAPDIVIGHSLGDYAAAVAAGALSFDAAMRVAALRGRLAATSARPGGMVAVAAGRDAVAPHLARGAAIAVDNGPAQLSVAGDAAALAETVRRLEAAGIAARPLPVSAAFHSPAMEPMLDAFRAALADVAMQPLRVPMVCNRTGAVLPAGTMLDAEFWVRHLREPVRFADGVRALAREGVALGLEIGPSAMLSRLAPLSAPTLSVVPSLARGTRDRDALLAAVGALWVAGVTPDWRAIDGPDRVHAELPLYPFDDAPFPLLADGTVAAGAIASSGAFGAREAGPAPSPPQASPSLPATPAVAAASASNAAARERALDIGAKLRDAIAEALETSPDRVDPTVPFIEMGADSLVLMAAARKIEAAFGVRIPMRAFFDELSTMEALATYLAAESPRPAAASDRAPAAPSSPGFVAQVVREQLALMRRQLDLLEGRRAAGEPEMPDDAARALRAEIARAERMGDRGEDGRREEGGSEEGRGEWHGGGKDGHGGGDGSGKGGDGSDTGRAVPAVRATRRANTVRDALSPRRQAHLDKLIGDYTRRTAGSRALAARYRDVMADSRASAGFRPSIKEMLYPIVCRSAAGATFEDVDGNRYLDLSMGFGVHLFGHAPDFVTAALRESLSRGLRLGPQADRAGEAAAVIARLSGQDRVAFVNSGSEAVMVALRLARTVTGRERVVIFRGAYHGHFDGVLADAADPADPAAGGAPLVPGVARGAVADTLVFDYGDPASVDTLAAQLGHVAAVLVEPVQSRRPDLQPAAFLRRLRALAEQAGALLIFDELITGFRIAAGGAQAHFGVKADLVAYGKILGGGLPIGALAGRADVMAAVDGGAWRYGDDSAPTAETTLFAGTFNKNPLSIDACVAVLTEIERRGDALYAQLNERSARLHARLEQALAGTPIGIARFGSVFRFVFGRNLDLFFYHLLLRGIYVWEGRTCFLSAAHTDADCDRLVVAVADAVAALRDGGMLDEGEGDHEGEVEGEGEGGPTADPAARDYAAPHADTDTHTDTLPMIRAQRQLAALAEMDPAGAVAYALPLLLALDGPLDAARLRDAVERAAARHDGLWVAMDPLSGTLRMMPPGRLTLGVQALDAAALDAQVRRQMAAPFDLKAPPLLRATLFAFADGTHALLLVGHHAALDGFSLQVLAADIAACYRGAPLPRAASLRRVLAAHRDAERDGRWAAARDGWRARLRDAPAGFDLDVAAPRPPMRALRGAREVRRIEAASARALRARAAAERTSLLAVMLAGFAWLLARHGAADVVIGVPYAGRALAGDGAQRVVGYCAHLLPIRLRAGAVDSVAALLAHTRAALIEALDHADYPFAHIVDDLALKRDPARPLLVPATFNVDRVPPALDFGEGVAARLRSPAVGAGRFDLACNVIDDGDALTVEFDHDEALYGGGRAQRLADEYLQLLEALAQGGERPLHDGAGHVARWATVVAAGRAEPLAVRWRRHLERAPQQVAVAVDGDARLSRAALDRWSDAVADAIEGAISGVRAGVIEGVIDGAVEDKIEGAAEAARASATAGPVALLLPRTEALPVAMLACWKAARAWLPIDPATPAERIAEMIRRAGCALVVRDAATAAAADGAIAPRCATLDLPPRAAAGRRAARRPWPAPNPEDVAYVLFTSGSTGRPKPVAVPHRALEWYVQGLLARLGLPSGLSCGLVSTFAADLGLTATLPALFDGGCLCIQSDAAARDPLLLAAVHRKRPVDLLKIVPSHLEALLAGAPDPLLLPRRVLVLGGERAGPGLLRRLAECAPPALRVMNHYGPTETTVGVAMGEWTRGADALRLDAPLAGAALVLLDDAGRRAPAGVRAQLYVGGPQVALGYPGCPDETAARFGARPASGVAGPLYATGDLGRLDADGTLTIVGRTDDQAKIRGYRVEPGEVAAALEGLPGVASAAVVAAEHPARGTVLVAYVAGDGAQADPASLALALHARLPDYMMPARIIPCRSLPLTANGKLDRGALPAPDWATHAPGEPASATVSSEAERVQATLVAVWRELFGRPDIGVHDEFFALGGDSILGIRMVARLHRDGLRLLASDLYRHPTIAALAPLIRPVDAQAEQGVLSGPVPLLPAQRRWLEIGAGLRPHANLSLLLELDAEVTPARVADAFARLLHQHDGLRMRARTDGGELVQTYGPPAPVPLHRVAAGHATPAALTRLQALADPAASPLVLGWLDGAPSRLLIVMHHWITDAVSCAILLDDLARLLRDPDAPLGPKTPSLRQWAQTLTERAASPDALAQLEYWTLSTSLPPPALPARSGGARGDAADGEWPGAPGAVGLTLSADETRDVTAGPAAQAGAETEDLLLAALALALGGRTGEPLLYVELEGHGRTPPDGLPEPARTIGWFTARHPAWFDLTGVPEAAAVAAVRAQRLSIPNRGADYGALRHLGPDHARDALAAGRRPAVSLNWLGQLAGIEHAPFRLVSWRPGCPLRGAERAADLPQPHALAVETMLIDGCLRIEFIYDAARFDAATIDTLAADYAAALLRLARERAAPPAPPPDSPGELDADDLAALAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L40</accession>
    <name>Q63L40_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528404.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111181.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1168"/>
    <dbReference type="EnsemblBacteria" id="CAH38636">
        <property type="protein sequence ID" value="CAH38636"/>
        <property type="gene ID" value="BPSS1168"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1168"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4399"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAMYARI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="131"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="29957" checksum="B8D99D3299008ED4" modified="2004-10-25" version="1">MDRAHRSPAGPVDTLLDGLIAKNAYYPRRIGGAMRVHALGDHAVVNSGLATDTFNLVISRAADGAQANAIAPIARDFDEAGLPAAWWTCGEWSDAAFARALGEAGFVADETSVGMLAELDALPCVAAPRGLRVRQISGADDVARFGALICALFDPPDPFVDAFYLHVAALEIDPAEPLKLFLGEIDGCAVSTAALYLDAGTAHVFDVSTAAHARRRGYACAVTHFVLAHARDRLGAARAALQASPDGLNVYRRLGFRPVCEFRVYSNRAAVLERSHDQHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L66</accession>
    <name>Q63L66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrogenase/oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528368.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111155.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1142"/>
    <dbReference type="EnsemblBacteria" id="CAH38610">
        <property type="protein sequence ID" value="CAH38610"/>
        <property type="gene ID" value="BPSS1142"/>
    </dbReference>
    <dbReference type="GeneID" id="56530444"/>
    <dbReference type="KEGG" id="bps:BPSS1142"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4366"/>
    <dbReference type="eggNOG" id="COG3260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WNPREAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="18356" checksum="E71E306414958B71" modified="2004-10-25" version="1">MWQLIKQIARTGRPNEPAPAGEDAWRRDAQCIRQEILDILGRALCIRAIDAGSCNGCELELHALGNPYYNIEGLGIKFVASPRHADMLLITGPLTLNMRDAVRLAYDATPAPKLVVAAGDCACTGGVFAGSYAVCGPIETLVPVDVAIPGCPPRPIELLRGIRGALERTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LD1</accession>
    <name>Q63LD1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage baseplate assembly protein V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205528.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111090.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1078"/>
    <dbReference type="EnsemblBacteria" id="CAH38545">
        <property type="protein sequence ID" value="CAH38545"/>
        <property type="gene ID" value="BPSS1078"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1078"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4276"/>
    <dbReference type="eggNOG" id="COG4540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PPDIDEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013046">
        <property type="entry name" value="GpV/Gp45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040629">
        <property type="entry name" value="Phage_spike"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18715">
        <property type="entry name" value="Phage_spike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01644">
        <property type="entry name" value="phage_P2_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_spike" evidence="2">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="226" mass="23572" checksum="D0DDE39158B9F0DC" modified="2004-10-25" version="1">MDANEIQRQARNAVRKGSILDVDHKAALCRVAIGESDDDGLQTNWIPWLTPSAGATREWLPPTKGEQVVVLGAMGDLAQGVALRGVFSDAFPAPDHLPNTHTRVYADGARVSYDHDAHALTAELPAGATVRLVAPVSVTVETESAIVKAASVTLDAEQTTCTGALLVKGPLAFESGMTGSGSAGGSHVMRIDGAADFTGEVRSMGKSLPFHTHQARGESAEVSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LI5</accession>
    <name>Q63LI5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205508.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111036.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1030"/>
    <dbReference type="EnsemblBacteria" id="CAH38491">
        <property type="protein sequence ID" value="CAH38491"/>
        <property type="gene ID" value="BPSS1030"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1030"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4215"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWFIASS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="326" mass="32663" checksum="A710B47B7A468E5C" modified="2004-10-25" version="1">MRDATDRLSRLAALGALAAVLAFFAVAAPGFATLANVERVLVNNFALLAIAALGMTLALSIGAIDLSLGTAIDVASLAFVCALAHRAGCASAALAGLGAALALGATNALLVTRLGIAPFLATLGTLFIGQTIQQLATDGGQPIYLLSTAPPPAFDALAHGVWLGVAAPLWIVAALAGALHVALERSTLGRQARALGAQPGVARHSGLRVGALAAGVFVASALVYGVAGLVLSSTVRSYAPQAGNAYLLNAIGATFIGATLSEARRPNVAGTLLGVLLVSFVANGLLLIGWNFYWQQVASGALVFAVLALGSGVGRERRARDAGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LJ8</accession>
    <name>Q63LJ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111023.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38478">
        <property type="protein sequence ID" value="CAH38478"/>
        <property type="gene ID" value="BPSS1017"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1017"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5145"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PNAGCRM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="28133" checksum="E705BF1D688F5CB3" modified="2004-10-25" version="1">MNEDGRRAAVADGRGRACSTMARPRERPPITLVRPSRFPMIVDRLISEILFGFTGLMGIINPFGIAFLFLERTESLTEAQRAALARKVAINAFIVLLAAFFVGTPILHFFGISLEALRIGGGLAVAVAGWQMLNEPDVPTGGDTAAQPVEPRNAMARAFFPLTIPLTTGPGSIATAIALNANRTHKLSEFVLSSIVSVAVSALAALVIWQTYSRAAFLARYLGTEGTKVAMRVSAFLLLCVGVQIMLTGFSEFLRPIADQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LN8</accession>
    <name>Q63LN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198668.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110983.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0975"/>
    <dbReference type="EnsemblBacteria" id="CAH38437">
        <property type="protein sequence ID" value="CAH38437"/>
        <property type="gene ID" value="BPSS0975"/>
    </dbReference>
    <dbReference type="GeneID" id="56597341"/>
    <dbReference type="KEGG" id="bps:BPSS0975"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7295"/>
    <dbReference type="eggNOG" id="ENOG5032YVI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIVPTYC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024651">
        <property type="entry name" value="FAD-SLDH_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12318">
        <property type="entry name" value="FAD-SLDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="171" mass="18399" checksum="F756FECA717D668D" modified="2004-10-25" version="1">MNNDTNPHARRSIDADEPMGGGLTRRQWLQRSLALTALGLAGSLTLRALADAPSAAPLDAFMTLSEALTGKTGLNRAVGERLLRALQKGSFELGDRLPKLAGALAANALAPDQEALALRILEAWYLGIVENVVVTYEEALMFGVVSDTLVIRSYCPNKPGFWADKPIERQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LR3</accession>
    <name>Q63LR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205487.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110958.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0950"/>
    <dbReference type="EnsemblBacteria" id="CAH38412">
        <property type="protein sequence ID" value="CAH38412"/>
        <property type="gene ID" value="BPSS0950"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0950"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5062"/>
    <dbReference type="eggNOG" id="COG1124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QARCRRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="16"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="28414" checksum="14D3EDF9860C697E" modified="2004-10-25" version="1">MAHVGRTMSDAPMIDIRDVSIRFPTRGGHVDAVRGASLAVGAGEAFGLVGESGSGKSTLLRALTGLVPLAGGTLSIDSRAVEGKLDRAFRRDVQMVFQDPYASLHPRFTVDETLREPLAIHRLPDADARIARALAEVGLGPAFRFRYPHQLSGGQRQRVAIARALIVEPRVLLLDEPTSALDVSVQAEILNLLKRLHRERGLTMILVSHNLAVVGFLCSRVAVMRDGALVEQLGIEDVRAARVGSEYTRTLLRATQGYRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LU9</accession>
    <name>Q63LU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-11" db="PDB data bank">
            <title>Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP.</title>
            <authorList>
                <person name="DeBouver N.D."/>
                <person name="Abendroth J."/>
                <person name="Lorimer D.D."/>
                <person name="Horanyi P.S."/>
                <person name="Edwards T.E."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS)</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195426.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110922.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="7SWH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.25 A"/>
        <property type="chains" value="A/B/C/D=1-433"/>
    </dbReference>
    <dbReference type="SMR" id="Q63LU9"/>
    <dbReference type="STRING" id="272560.BPSS0913"/>
    <dbReference type="EnsemblBacteria" id="CAH38375">
        <property type="protein sequence ID" value="CAH38375"/>
        <property type="gene ID" value="BPSS0913"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0913"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7210"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LRMERAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7SWH"/>
        </source>
    </evidence>
    <sequence length="433" mass="46679" checksum="5CBBF85F4E402603" modified="2004-10-25" version="1">MTYSSYHKKDIEGRPLHPETQMMSYGFDPFLSEGAVKPPVFLTSTFAFRSAEDGADFFDIVSGRKPLPQGEAAGLVYSRFNHPNLEIVEDRLALLDGSEAAVVTSSGMSAISAIFLAFLRPGDQLVQSVPLYGGTETLIAKYFREWGVGAHSIDNGLSPQAIGAALEAAAQQGPVRLCYVETPANPTNALIDLDGMRRELDAFEARHGYRPISVCDNTLLGPIFQKPSEHGVDMSVYSLTKYVGGHSDLVGGGVTGRRDLVAKVRAVRSAFGSQLDPHSSWMLIRSMETVVLRMKQAARTASAVAKWLATNPHQKVDVYHPELIVDDAYQAVYKRQCTGAGSTFAFVLNGGRAEAFRFINALHLFKSAVSLGGTESLICHPASTTHSGVPEAARKAAGVSEGLIRVSIGLEHEEDLIADLDHAFRRSGLATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LW1</accession>
    <name>Q63LW1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528161.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110910.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0901"/>
    <dbReference type="EnsemblBacteria" id="CAH38363">
        <property type="protein sequence ID" value="CAH38363"/>
        <property type="gene ID" value="BPSS0901"/>
    </dbReference>
    <dbReference type="GeneID" id="56530644"/>
    <dbReference type="KEGG" id="bps:BPSS0901"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7194"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNHAYSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="28375" checksum="D9AB37332AB45DCE" modified="2004-10-25" version="1">MIQIDLSGQVAVVTGGSSGIGYASAELFLRAGASVAICGRGDERLASAHARLVRQFPRERVLAVRCDVLDEADVTAFAQAVAERFGGADMLVNNAGQGRVSTFADTTDDAWRDELELKYFSIIRPTRAFLPLLRASSAPSITCVNSLLALQPEPHMVATSSARAGALSLVKSLATELAPERVRVNSILIGIVESGQWRRRYDAQAAPGESWEAWTAALAAKKNIPLARFGRPDEAAWALFYLATNLSSYTTGSHIDVSGGFARHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LX4</accession>
    <name>Q63LX4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein MgtC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184903.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110897.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0888"/>
    <dbReference type="EnsemblBacteria" id="CAH38350">
        <property type="protein sequence ID" value="CAH38350"/>
        <property type="gene ID" value="BPSS0888"/>
    </dbReference>
    <dbReference type="GeneID" id="56597248"/>
    <dbReference type="GeneID" id="66549725"/>
    <dbReference type="KEGG" id="bps:BPSS0888"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7180"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAQIVQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="238" mass="25195" checksum="0B9027B020F09C9F" modified="2004-10-25" version="1">MTFEFALRLFTAFACGVAIGLERQIRQRTAGLRTITLVASGACLFVTLGVLTGNGIPGVTQIAAYVVSGVGFLGGGVIMRDKGSIQGINTAATLWCSAAVGVLSGAGHYLPALAGTGVVLLTNTLLRGVSQAINATPVSNADLVREYQITVICLASDEVHIRTLLSNSMYAKPLSFQSLTSEDVPREADAPERIKVTATLKLHPKDQQKLEQIASRMSMEKSISSVSWTAKEAEPLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M11</accession>
    <name>Q63M11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551557.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110860.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38311">
        <property type="protein sequence ID" value="CAH38311"/>
        <property type="gene ID" value="BPSS0848"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0848"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7133"/>
    <dbReference type="eggNOG" id="ENOG5032UJB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QHYELMI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="17954" checksum="21E8123EA575ECBF" modified="2004-10-25" version="1">MSSISSRPHKRPPASPWLSLVIRLLGVSFVLFFGAAIVTILLGIDHRAAGDPIGLLVLRLVRWGGVHGGGEHYELMISTVYVVWGAFLWKAADAPFEHALFLDFTVVANVAHFGLMFVQGLTMPGEHLHLVGDVALGWLALALFAATWLPARGNTRKRHTAGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M95</accession>
    <name>Q63M95_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523879.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110776.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0765"/>
    <dbReference type="EnsemblBacteria" id="CAH38225">
        <property type="protein sequence ID" value="CAH38225"/>
        <property type="gene ID" value="BPSS0765"/>
    </dbReference>
    <dbReference type="GeneID" id="56530784"/>
    <dbReference type="KEGG" id="bps:BPSS0765"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7007"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQFTDAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="238" mass="25938" checksum="C23235713DDDA38C" modified="2004-10-25" version="1">MAPRIVPPALEAIEQETMTDKVYQQLREALMSGRFAPGQALSLRSVAEAVGSSTMPVRAALTRLRAERALADGPNRALVVPPMTIEMLDELRDVRIALEGCVAERAATRMSVSQIAEVRRICEAMNAHVEAGRSRAYLQSNFAFHSAIYAHGASENTLAIIRNLWMRIGPFLNMIALDVPHMRRSMDAHRAIVDALERRDGAGARAGIALDIGGAAHDLAETLAAERARLGPRRLANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MG5</accession>
    <name>Q63MG5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ureidoglycolatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Ureidoglycolate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536957.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110706.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0692"/>
    <dbReference type="EnsemblBacteria" id="CAH38152">
        <property type="protein sequence ID" value="CAH38152"/>
        <property type="gene ID" value="BPSS0692"/>
    </dbReference>
    <dbReference type="GeneID" id="56530858"/>
    <dbReference type="KEGG" id="bps:BPSS0692"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6906"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGTPHSR"/>
    <dbReference type="UniPathway" id="UPA00394"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008704">
        <property type="term" value="F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018800">
        <property type="term" value="F:5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012686">
        <property type="entry name" value="HPA_isomer/decarb_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02305">
        <property type="entry name" value="HpaG-N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="23869" checksum="FA21D4465CF014CD" modified="2004-10-25" version="1">MELSLVERGERVATVPIGTVYGALLNDRGALAALGDAVHAPPYHKPPRASVLYVKPANTHAGDGAAVVVPAGVDALEIGATLGVVFARRTTRVPAEQAFDFVKGFTLASDVSIPHPDYYRPAVRFKCRDGFCPLGPAIVARASIGDADALAVTVRIDGERRYEASTANLIRPVARLIADVSAFMSFDAGDVLLVGVGPHAPRAAAGSTIEIDAPGIGTLRHTLVAEDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2019-12-11" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ9</accession>
    <name>Q63MJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS0652a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527918.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38111">
        <property type="protein sequence ID" value="CAH38111"/>
        <property type="gene ID" value="BPSS0652a"/>
    </dbReference>
    <dbReference type="OMA" id="TWIDNRH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="80" mass="8842" checksum="35F556F2DC1E9822" modified="2004-10-25" version="1">MQVDGHQHLADFWGCYVNLDDLVILNDSLFIDDTTKACHDLEGQALSIPRVASAELAATRTWIDNRHHTLPCVVATVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS1</accession>
    <name>Q63MS1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">braE</name>
        <name evidence="8" type="ordered locus">BPSS0577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0577"/>
    <dbReference type="EnsemblBacteria" id="CAH38034">
        <property type="protein sequence ID" value="CAH38034"/>
        <property type="gene ID" value="BPSS0577"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0577"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VFWYKLQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021807">
        <property type="entry name" value="LivHM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11862">
        <property type="entry name" value="DUF3382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3382" evidence="7">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="44158" checksum="1B95CCD42B4A4D5C" modified="2004-10-25" version="1">MPAVQSLKHAVTAAVLTAILTVPILGLQLKLDGYQVVLEAHWRPVWIAVAAVFLFQLFKPALMRAKAAVRLPAAPPLGVREQRAIVWALVALGFVWPFFGSRGAVDVATLALIYVILGLGLNIVVGFAGLLDLGYVGFYAVGGYTYALLNQYFGLSFWECLPLSALASATFGFVLGFPVLRLRGDYLAIVTLGFGEIIRLLANNLTSITGGPDGISGIPKPTVFGFEMARSASVEGAKTFHELVGLEYSGEHVVIFLYLIALVLVCFTLFVTSRLIRMPMGRAWEALRDDEIACRSLGLNPTRIKLSAFTLGASFAGIGGAFFAARQGLVNPESFTFIESALILAIVVLGGMGSQLGVILAAILLTLLPEVARGFAEYRMLIFGLVMVLMMMWRPQGLLPASRPHVELPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MZ6</accession>
    <name>Q63MZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205418.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110523.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37959">
        <property type="protein sequence ID" value="CAH37959"/>
        <property type="gene ID" value="BPSS0502"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0502"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6659"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGLVMGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="500" mass="53463" checksum="D3E7437FA2A2D546" modified="2004-10-25" version="1">MARGKTAIPLDLPRPPGLSVRRAQSKQDCIGDALRDAILRKLLPGGSPLPSTRTLAARWGVARGTVEAAFDRLCAEGYIARAHGSGTRVSAVVPDAYLSPARHPAKPAPHARGKPADALARERAAEADGSVRAGVPFVARLADPGLLPMRTWKRHIGIGLSEATHAALCALPPQGAEPLRARIADYLGQYRGIACDAADIFITTGIRHSLDLIARTIAGSGSRIAIEDPGYRTARRIFELAGAESICVAVGPEGIDTHALSAHRRVAAAYVTPAHQSPLGVTMSISRRLDLLDWAHARRTWVIEDDYDGEFGYQSAPLPALKSLDVRERVIYCGSFNKTLFSGLRVGFMVVPAALRAPISALVQAVGRPVGTTEQLTLASFIGSGDFAKHLRTSRHAYLQRRDAVLEQLRRYADGQYAISGEHTGFHFVLWLGRGIDERTFAEEAANIGLALEPLRAFCTQAALPAGVVVGYSALSVAQARYAGKKLGQLLAGVRRDAAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N20</accession>
    <name>CH602_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL 2</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60 2</fullName>
            <shortName evidence="1">Cpn60 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL2</name>
        <name evidence="1" type="synonym">groL2</name>
        <name type="ordered locus">BPSS0477</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529993.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110499.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63N20"/>
    <dbReference type="SMR" id="Q63N20"/>
    <dbReference type="STRING" id="272560.BPSS0477"/>
    <dbReference type="EnsemblBacteria" id="CAH37933">
        <property type="protein sequence ID" value="CAH37933"/>
        <property type="gene ID" value="BPSS0477"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0477"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6626"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYILINQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000063319" description="Chaperonin GroEL 2">
        <location>
            <begin position="1"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="546" mass="56974" checksum="F2A4D2C5D7761B1F" modified="2004-10-25" version="1">MAAKEIIFHDGARAKLVEGVNLLANAVKVTLGPKGRNVVLERSFGSPVVTKDGVSVAKEIELADKVQNIGAQLVKEVASKTSDAAGDGTTTATVLAQAIVREGQKYVAAGLNPLDLKRGIDKAVAAAVDELKKISKPTTTSKEIAQVATISANGEESIGQRIAEAIDRVGKEGVITVEDGKSLADELDVVEGLQFDRGYLSPYFINHPERQLAVLDEPFILLHDKKISNIRDLLPVLEQVAKAGRPLLIVAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKALLEDIAILTGGQVITEETGLTLEKATLQELGRAKRIEVGKENTTLIDGAGDKPNIDARVKQIRAQIAEATSDYDREKLQERVAKLAGGVAVIKVGGATEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALIRVKQAIAALAGANADQKAGISIVLRALEEPLRQIVANAGEEASVVVATVAAGQGNYGYNAATGEYGDLVESGVLDPTKVTRTALQNAASIAGLLLTTDATVHEAPKDAPPAAPAGVPGAGGPGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N36</accession>
    <name>Q63N36_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525489.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110483.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63N36"/>
    <dbReference type="STRING" id="272560.BPSS0461"/>
    <dbReference type="EnsemblBacteria" id="CAH37917">
        <property type="protein sequence ID" value="CAH37917"/>
        <property type="gene ID" value="BPSS0461"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0461"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6608"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NQFHYFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="34"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="46391" checksum="86850C4FA403780A" modified="2004-10-25" version="1">MLKFINQPHAASYYAATVNDTTRHPPLEGTIDADVCVIGAGLTGISAALNLAERGHSVAVLEASKVGWAASGRNGGQLIGGFACGIDAFEPYLNADEIRLVWDMGLETLAIAKERIAKHAIDCAFVPGYLSAANKPRDVDALRRSRDEAARRFGYTRLRYVERDALAQYVQSSRYLGGLFDPDSGHLHPLNYTLGLARAAVASGARIHEDSAVTRIASEAGGHVVSTARGAVRARFVVLACNAFLGALAPALSRKIMPVGTYVIATEPLGEARARALMPAQAAICDSRFALDYFRPTPDARLLWGGKVSYSTLEPRKLADAMRRDMLKTFPQLADVTIEHAWGGFVDITMNRAPHFGRLTPTVYFAQGFSGHGVNTTGLAGKLIAEAIDGQAARFDVFGKIRHRDFPGGAALRMPALVLAMAWYRLRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N66</accession>
    <name>Q63N66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537066.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110453.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0429"/>
    <dbReference type="EnsemblBacteria" id="CAH37885">
        <property type="protein sequence ID" value="CAH37885"/>
        <property type="gene ID" value="BPSS0429"/>
    </dbReference>
    <dbReference type="GeneID" id="56531121"/>
    <dbReference type="KEGG" id="bps:BPSS0429"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6567"/>
    <dbReference type="OMA" id="LARQPCY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="349" mass="37878" checksum="774035CE0CD85BA9" modified="2004-10-25" version="1">MFFCYVLFLIFYWSPAIVLQWGTYGMFDDAVPMWYKALRLIVPAYGLVVLARQPYYTPAHLLYFVFGAWCVLVSGDLATSVNVLVFCATLVIMKGVRIDAAALRRVILAALPFVYGMGLLEVFGVFVSAHTYGSELRVVSTFGGPNNAGIIFSSWALYFIIEFRNARRLRDLGHAAACVSFVVLTGSLSAAVALAACAFVLNAYLIVPAVLVVVPTFLINDFFMLKLSYLMATLNGQGETTGSFSDRVENVATIARVAGDNVVNLIVGSGLHSESDYLSVLGQFGVVGLILFICVLLTLPRSLFMLLGLLQSLVTPFFFSFPSFPLIALLAAGEVAAEARKRAPRPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N78</accession>
    <name>Q63N78_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110441.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0417"/>
    <dbReference type="EnsemblBacteria" id="CAH37873">
        <property type="protein sequence ID" value="CAH37873"/>
        <property type="gene ID" value="BPSS0417"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0417"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6553"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMGEVQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010425">
        <property type="entry name" value="Caps_synth_GfcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06251">
        <property type="entry name" value="Caps_synth_GfcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="378"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Caps_synth_GfcC" evidence="3">
        <location>
            <begin position="659"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="850" mass="90496" checksum="605D92E00F6362BF" modified="2004-10-25" version="1">MNVKSPILRHPRTWAGFSFRDGLPFIRFASLRLLAWLLRCAVCLWPCAFPVFAHAQIVPFVPSASAGADARSAVPLPPIDSLPAADGLSARQRDALQPPLPGAKLTKDATTKDGLLKDGAALNEPPRPCGPLGCRGEAIDCPPSADGRPTSITRRADGTPELPDPCGRPRAASQPALTDFQVFVQQSTGRALPLFGYNFFSTTTTYRSLDNVPVPDDYVLGPGDEVLLHAWGGVAGDQRLVVDRNGQVSIPGVGVVTVAGARASELDSLLRGGLGRYFTDFNVNAALGRLRSIPVYVVGKAMSPGSYTVPGTSTIIGALFASGGPAFNGSMRAVALYRNGRQIAALDVYGFLTRGAVKDDVHLLPGDVIVIPPAGPRIALTGALDAPGIYELRKTSETLRELLDDAGGVTALTSLDRVMIERVNPADGAAPRSVQEVRLDEAGLATVVKDGDIVTLSMVSQKFSNAVTLRGNVAAALRYPYKPGMTLADLLPSPEAVLTPDYFTRKNILVEYAKSGGADRRPFDGIRNLVDEPNWHYAIIQRLDPVTLTENVIAFNLRAVMTKGSAEAGIALQPGDVVTIFGKRDLRNPVDDNKSLVRVDGEVRAPGVYQLNAGESLRELLQRAGGLTSNAYVFGLEFTRESTRSQQQQNLNAALDRATLQANSKLAAALANLPSGDTQYLQAQMAAAQQAQLARLRELKPTGRVSLELSTRASRIGDLPDLPLNDGDAIYVPPVPAFVTVYGAVDNQNAVIWKLHRTVADTLRVAGVQRDIADLDAAFVLRADGSVASASSAGWFGSFGALELMPGDALVVPEKLDRRTAMTKFLAGLKDWSQVLANFGLGAAAIKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N94</accession>
    <name>Q63N94_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriophage/transposase fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205400.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110425.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0402"/>
    <dbReference type="EnsemblBacteria" id="CAH37855">
        <property type="protein sequence ID" value="CAH37855"/>
        <property type="gene ID" value="BPSS0402"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0402"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6534"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAYDHRC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266469" evidence="2">
        <location>
            <begin position="18"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="258"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="391" mass="44066" checksum="726469A76341729F" modified="2004-10-25" version="1">MKRLFLILILVPTMFLAAGCDNVPAGYVGVKVQRYGDDRGVNVEVKGPGRYFNGPNVDMFIFPTFTQSYVWDKAGKSDESFTFQTVEGLSVNTDIGVSYAIPRENAPKVFQKYRRGVDEITGVYLRAIVRDALNLAGASMAVEDVYGRGKAALQQRVEDEVKANAAKVGISVEKVYFVNQMRLPEQVMNSINGKIAATQIAQQKENELRAAEADAAKQVAIAKGEAEALEVKAKALRENSQILQQMAIEKWDGKLPQYARRAVGWAFSQHADTDLALKALRRAYDHRRPPPGLMFHSDQGCQYTSTRFLAELRARGTIQSMSRRGNCWDNAVVERFFRSLKNEWIGDQLYVDHRHAEQDITDYLVDFYNHRRLHSAAKGLRQTYRFGVQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NA4</accession>
    <name>Q63NA4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS0391A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552308.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110415.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0391A"/>
    <dbReference type="EnsemblBacteria" id="CAH37843">
        <property type="protein sequence ID" value="CAH37843"/>
        <property type="gene ID" value="BPSS0391A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0391A"/>
    <dbReference type="OMA" id="PMFEREY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="19519" checksum="4859D36EBFF22FCE" modified="2004-10-25" version="1">MVDMYALTLPVLTHPWLEGESPLQLAPDSPRILLRSVERLAHYFKREMYFDFVQSDATETKESKGFVPYQAYAFFAPARDRWQDDKPMPHRVFGACCFRDRDSSSGAPSWSLDWVWMHPYFRHRGHLKEAWPMFEREYGEDFHVEEPVSLAMRSFMEKYASIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU5</accession>
    <name>Q63NU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsr</name>
        <name evidence="6" type="ordered locus">BPSS0204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531504.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110224.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0204"/>
    <dbReference type="EnsemblBacteria" id="CAH37649">
        <property type="protein sequence ID" value="CAH37649"/>
        <property type="gene ID" value="BPSS0204"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0204"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6274"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IALVCFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266632" evidence="3">
        <location>
            <begin position="25"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="206"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="263"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="542" mass="56526" checksum="20909D9CFA1F3F90" modified="2004-10-25" version="1">MKLRRKIPLAFATALVLTSASAFYGIHALNRSLDTYGTTVRQNVANERMVSATLVAFKLQVQEWKDTLLRGKDPAKLDKYWRAFQQREQTVDALAAELKAKLPDGESRGLIEQFASAHAEMGQGYRKGFEAFRASGFDPSAGDQAVAGVDRAPAVLLEKAARDIAADSARVSADAASDAAHATAISIAATFALFALSLAGGVWFGGTVTRPLERALACVRRVATGDLSTPIDARGRDEIAELLAALKDMQASLSHVVRDVRHNADGVATASAQIASGNLDLSSRTEEQAASLEETAASMDELTSTVRRNAEHAQHACAVAAGASTKAARGGDVMRQVVDTMRGIADSSGKVAEIIAVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLAQRSATAAREIKTLIEQSTERVGAGSALVDDAGRIIGEIVDSVRQVTGIVSEIAAASNEQSVGIEQVNRAVAQMDNVTQQNAALVEEASAAAHALAEQAHALHGAVAVFSLHGERAGERGCAHAGQPAVEAAHDSPRTALPVVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ6</accession>
    <name>Q63NZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196262.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110173.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37597">
        <property type="protein sequence ID" value="CAH37597"/>
        <property type="gene ID" value="BPSS0152"/>
    </dbReference>
    <dbReference type="GeneID" id="56531398"/>
    <dbReference type="KEGG" id="bps:BPSS0152"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6205"/>
    <dbReference type="eggNOG" id="ENOG502ZKYC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYGHRKH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266635" evidence="2">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="13526" checksum="57F08BF56DAFB6F3" modified="2004-10-25" version="1">MSKKLIQIMAVAALSAAASLPAFAGDMNNALGGALGGVAGAAVGGAVGGSTGAVIGGAVGGGAGGAVTSNRRERTGAIIGGALGGGAGTAAGNAMGGRGGGLIGAAVGGGAGAALGGNISRSNSYNDDYDRGYRRGKHHGKHHHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PC8</accession>
    <name>Q63PC8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative D-beta-hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194455.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110041.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0017"/>
    <dbReference type="EnsemblBacteria" id="CAH37460">
        <property type="protein sequence ID" value="CAH37460"/>
        <property type="gene ID" value="BPSS0017"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0017"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6013"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HMFARAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011294">
        <property type="entry name" value="3-OHbutyrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01963">
        <property type="entry name" value="PHB_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="27421" checksum="D3C596D145DC27BA" modified="2004-10-25" version="1">MSNLNGKTAIVTGAASGIGKEIALELARAGAAVAIADLNQDGANAVAELIEQAGGRAIGVAMDVTNEDAVNAGIDKVAQTFGSVDILVSNAGIQIVNPIENYAFADWKKMQAIHVDGAFLTTKAALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTAKHGLLGLARVLAKEGAKHNVRSHVVCPGFVRTPLVDKQIPEQAKELGISEEEVVKKVMLGQTVDGVFTTVEDVAKTVLFLSAFPSAALTGQSFVVSHGWFMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PD9</accession>
    <name>TDH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="1">TDH</shortName>
            <ecNumber evidence="1">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdh</name>
        <name type="ordered locus">BPSS0006</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194543.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110030.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PD9"/>
    <dbReference type="SMR" id="Q63PD9"/>
    <dbReference type="STRING" id="272560.BPSS0006"/>
    <dbReference type="EnsemblBacteria" id="CAH37449">
        <property type="protein sequence ID" value="CAH37449"/>
        <property type="gene ID" value="BPSS0006"/>
    </dbReference>
    <dbReference type="GeneID" id="56596749"/>
    <dbReference type="KEGG" id="bps:BPSS0006"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6000"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQICDKE"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000160833" description="L-threonine 3-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <sequence length="343" mass="37461" checksum="7B68D10DE57B44E7" modified="2004-10-25" version="1">MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMSGVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAVDDYEKGFAAMLSGESGKVILDWADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PJ6</accession>
    <name>Q63PJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195850.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109973.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3379"/>
    <dbReference type="EnsemblBacteria" id="CAH37391">
        <property type="protein sequence ID" value="CAH37391"/>
        <property type="gene ID" value="BPSL3379"/>
    </dbReference>
    <dbReference type="GeneID" id="56593877"/>
    <dbReference type="KEGG" id="bps:BPSL3379"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1817"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DCAVETI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04784">
        <property type="entry name" value="HTH_CadR-PbrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011791">
        <property type="entry name" value="CadR-PbrR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02047">
        <property type="entry name" value="CadR-PbrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="143" mass="16465" checksum="AE032F108B383A0B" modified="2004-10-25" version="1">MKIGELAKAARCTPETIRFYEKEGLMPDAERTDSNYRHYTDAHVERLRFIRNCRALDMTHDEIRALLRFTDDPADRCDSVNALLDEHIGHVNTRLAELQHLRMQLIELRERCQGEHAVEDCGIVHGLATMETPDMPGKRSHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY6</accession>
    <name>Q63PY6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PutativeAsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202739.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109832.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37249">
        <property type="protein sequence ID" value="CAH37249"/>
        <property type="gene ID" value="BPSL3238"/>
    </dbReference>
    <dbReference type="GeneID" id="56594592"/>
    <dbReference type="KEGG" id="bps:BPSL3238"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1999"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPSKLHM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="171" mass="19231" checksum="179B9D2A233C4503" modified="2004-10-25" version="1">MAHVELDAIDRRILSILQENGRLSNQDIAERVNLSPSPCLRRIRRLEEMGVITGYVALLDPQKLGLDLLAYVSVRLEKRGGVAPVRGDETSARAGATHAELFRAAVQAWPEVVACHAMTGDMDYLLRVQVEDMAHFSRFMQEQLLHHPSVIDVKTSFSLERFKETTALPIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PZ9</accession>
    <name>RL11_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">BPSL3225</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198368.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109819.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PZ9"/>
    <dbReference type="SMR" id="Q63PZ9"/>
    <dbReference type="STRING" id="272560.BPSL3225"/>
    <dbReference type="EnsemblBacteria" id="CAH37236">
        <property type="protein sequence ID" value="CAH37236"/>
        <property type="gene ID" value="BPSL3225"/>
    </dbReference>
    <dbReference type="GeneID" id="60548035"/>
    <dbReference type="GeneID" id="66545607"/>
    <dbReference type="KEGG" id="bps:BPSL3225"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2013"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104263" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="143" mass="14959" checksum="AE92CEF319994C0F" modified="2004-10-25" version="1">MAKKIVGFIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAQTQGMEPGLPVPVVITAYADKSFTFVMKTPPATVLIKKAAKVDKGSSKPHTDKVGKITRAQAEEIAKTKMPDLTAADLDAAVRTIAGSARSMGITVEGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q25</accession>
    <name>RS8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">BPSL3199</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185153.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109793.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q25"/>
    <dbReference type="SMR" id="Q63Q25"/>
    <dbReference type="STRING" id="272560.BPSL3199"/>
    <dbReference type="EnsemblBacteria" id="CAH37210">
        <property type="protein sequence ID" value="CAH37210"/>
        <property type="gene ID" value="BPSL3199"/>
    </dbReference>
    <dbReference type="GeneID" id="60548061"/>
    <dbReference type="GeneID" id="66545634"/>
    <dbReference type="KEGG" id="bps:BPSL3199"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2039"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126385" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="131" mass="14199" checksum="A1954D725B5A926B" modified="2004-10-25" version="1">MSMSDPIADMLTRIRNAQMVEKVSVSMPSSKVKVAIAQVLKDEGYIDDFAVKADGAKAELNIALKYYAGRPVIERLERVSKPGLRVYRGRNEIPQVMNGLGVAIVSTPKGVMTDRKARATGVGGEVICYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q72</accession>
    <name>Q63Q72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS</name>
        <name evidence="1" type="ordered locus">BPSL3153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199938.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109746.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3153"/>
    <dbReference type="EnsemblBacteria" id="CAH37163">
        <property type="protein sequence ID" value="CAH37163"/>
        <property type="gene ID" value="BPSL3153"/>
    </dbReference>
    <dbReference type="GeneID" id="56594075"/>
    <dbReference type="KEGG" id="bps:BPSL3153"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2090"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDIHINQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="65" mass="6572" checksum="5364B131908DA8FE" modified="2004-10-25" version="1">MDIQVNQQTFSLPDGATVADALAAYGARPPFAVAVNGAFVARTQHAARALAAGDKLDIVHPVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QA7</accession>
    <name>Q63QA7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552628.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109711.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3118"/>
    <dbReference type="EnsemblBacteria" id="CAH37128">
        <property type="protein sequence ID" value="CAH37128"/>
        <property type="gene ID" value="BPSL3118"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3118"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2125"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AAFEYFV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="7">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="6">
        <location>
            <begin position="291"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="866" mass="95570" checksum="053A795FD35D044C" modified="2004-10-25" version="1">MSKSANETETVIKRILPYLQRRGYEIETDLHFETAASTPERYEAGFVDILVWPNDKTYPKGKPAFLIEAKRIAKKLSEQDKKQALSYARADGYDVPFVVVCNGAEIRSYNAKTGEPIQWNGKLSSKIPAKSQLKSVLKDFKTDPQAVRIELPGEDGPLDGSSALPFRPSLPLRQLNALFSRCHDAIRKNEKDENHIFDDFSKLLFLKLLEEKADTEEGFNLPYSYTFHELAALPDAKADQVQNAIMDMIKKIRTDKSYGDVLANPIHLKVAKTFLYLVRQLAAVSFTDSTTDSKGAAFEYFVRATLKGKKLGQYFTPRPLVRLMSAIVGQEKIVNALLSGAAAPKVLDPACGTGGFLVYLMGDSLRVANQKLADRAINAATHRELVRKIRQQVFFGSDANEGVACAAKMNMIVAGDGHSNIQPENSLARTAKNWNIQDSDCDFILTNPPFGTSESGALSDKDMGQFEVQTTKGQLLFLQKMVLSARRGGEICTVIDEGVLNTDTAAPIRKWLLSKAKLLAVVRLPDETFRPNKINVRSSVLYLQRMTEEEEEIADDIKYPVAFCDIETFGMDGAGDIARNFDLDTLIDSVGKNILRTGRTRSGKHWSVFDVAVLMIRDDKASRFDVKYWRPGVTNAMKEIVSVGGKTIKELNTIPTARGTSPSADSYVDAADGYALVIKSGSNISRYGELIVDGDYIEKSLFDEYVEKAHTQGRNFNLVRPGDVLVSSTGDGTLGKCCVYRPSTDPITGETVPYAAIAEGHVAIIRVDPDVIWPEYLCDYLRVGFGAQQIERLYTGSTGMIELTPAALDEVVVNLLSGIEEQKKYSEALRKGEAQARSTSEQAASEMSAALDSFRSSTSTLLELTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QF5</accession>
    <name>Q63QF5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186915.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109663.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3068"/>
    <dbReference type="EnsemblBacteria" id="CAH37079">
        <property type="protein sequence ID" value="CAH37079"/>
        <property type="gene ID" value="BPSL3068"/>
    </dbReference>
    <dbReference type="GeneID" id="56597069"/>
    <dbReference type="KEGG" id="bps:BPSL3068"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2190"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVCTHDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="23149" checksum="CB323D0A8998686E" modified="2004-10-25" version="1">MTVKAVVFDFGGVLIDWSPEYLYRKLIPDEAERRWFLTHVCGMDWVVRQDGGQTIEEGTAERIALFPEHEALIRAFYARWHEMIGGELADGAALVDALDARGVPLFGLTNWSAQTFPYAWENFPVLRRFRDIVVSGRVKLAKPDPAIYREMHARIEPHLPGIAPHELVFIDDNAKNAAAAAALGWHGIHHTSAAATRARLRELGALG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QJ5</accession>
    <name>MURD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="1">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murD</name>
        <name type="ordered locus">BPSL3027</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH37039" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37039.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203798.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109623.2">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QJ5"/>
    <dbReference type="SMR" id="Q63QJ5"/>
    <dbReference type="STRING" id="272560.BPSL3027"/>
    <dbReference type="EnsemblBacteria" id="CAH37039">
        <property type="protein sequence ID" value="CAH37039"/>
        <property type="gene ID" value="BPSL3027"/>
    </dbReference>
    <dbReference type="GeneID" id="56594286"/>
    <dbReference type="KEGG" id="bps:BPSL3027"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2239"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000108988" description="UDP-N-acetylmuramoylalanine--D-glutamate ligase">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="504" mass="52549" checksum="5F5BD80F4EB8C5D7" modified="2006-10-31" version="2">MFGDRQRPMVLVLGLGESGLAIARWCARHGCRLRVADTRETPPNLAALTAAGVDFEFVGGAFSPALVDGGIELVALSPGLSPLAEDLAPLVAAARERGIPVWGELEFFAQALAALGANGYAPKVIAITGTNGKTTTTSLAGLLCERAGKKVAVAGNISPAMLDKLTEAIDAAALPDVWVLELSSFQLDTAHTFAPDAATILNITQDHLDWHGGFAAYAAAKGRVFGPRTVRVLNRDDAEVMRFAPPAAAADAPRAVTFGLNEPAADGDYGLLRENGIAWLVEAIDRDGADAPAAPSRRRKQEAANPPDIALKRLMPADALRIRGLHNAANALAAYALARAIGLPAAPLLHGLREYRGEPHRVEVIATLDGVDYVDDSKGTNVGATVAALDGLAQRAVLIAGGDGKGQDFEPLAAPVARWCRAVMLIGRDAPALREALADTGVPLADHATLEAAVRAASALAQPGDAVLLSPACASLDMFRNYAHRADVFRSAVEDIALEKGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QL0</accession>
    <name>Q63QL0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase inhibitor YacG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yacG</name>
        <name evidence="3" type="ORF">BPSL3012a</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with GyrB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA gyrase inhibitor YacG family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195120.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109608.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3012a"/>
    <dbReference type="EnsemblBacteria" id="CAH37024">
        <property type="protein sequence ID" value="CAH37024"/>
        <property type="gene ID" value="BPSL3012a"/>
    </dbReference>
    <dbReference type="GeneID" id="56594271"/>
    <dbReference type="KEGG" id="bps:BPSL3012a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2256"/>
    <dbReference type="eggNOG" id="COG3024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAAEEHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00649">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005584">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36150">
        <property type="entry name" value="PTHR36150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03884">
        <property type="entry name" value="YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="7290" checksum="365812864AC80808" modified="2004-10-25" version="1">MVTVVKCPSCGKEVRWTPENRFRPFCSARCKQLDLGAWAAEKYRIGGTDDAAPSEDDAADREGGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QW6</accession>
    <name>Q63QW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AraC_family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109502.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2908"/>
    <dbReference type="EnsemblBacteria" id="CAH36918">
        <property type="protein sequence ID" value="CAH36918"/>
        <property type="gene ID" value="BPSL2908"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2908"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3321"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYLQGWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="31524" checksum="96487BEA1B9E00EF" modified="2004-10-25" version="1">MTNRPMIDRLKDLLARFELHARVFHFGALPGASTFEIGADGFHMHLVRTGAVNVTGEALGRHAVPEPGAVFIGRPGKYRIEARGDAPVEVLSAAIEFGLGDENPLLRGLPDLLAIPLASMSPLGGVQQALFAEASAPACGHDTVINRLTEVLVVQLLRFVMRNRLVASGSLAGLSDARLAKALNAMHADPALPWSLERMAAIAGMSRSRFAAHFAGTVGLPPGEYLLQWRVGLAKTLLRRGYAVKEIAPEVGYGSASALTRAFAQSTGQAPTDWLARAGDAPGAIGAAADSMPDVGVRAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QX5</accession>
    <name>RUVB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name type="ordered locus">BPSL2899</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194268.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109493.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QX5"/>
    <dbReference type="SMR" id="Q63QX5"/>
    <dbReference type="STRING" id="272560.BPSL2899"/>
    <dbReference type="EnsemblBacteria" id="CAH36909">
        <property type="protein sequence ID" value="CAH36909"/>
        <property type="gene ID" value="BPSL2899"/>
    </dbReference>
    <dbReference type="GeneID" id="56593683"/>
    <dbReference type="KEGG" id="bps:BPSL2899"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2390"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000165509" description="Holliday junction ATP-dependent DNA helicase RuvB">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <sequence length="356" mass="39223" checksum="3931D5D7708C924D" modified="2004-10-25" version="1">MIETDKLAAERIIAATPASSHEEAFERALRPRQLDEYVGQEKVRDQLEIFIEAAKRRSEALDHVLLFGPPGLGKTTLAHIIAREMGVNLRQTSGPVLERAGDLAALLTNLEANDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYDAEQLSRIVRRSAALLNAQIDPAGALEIAKRSRGTPRIANRLLRRVRDYAEVKADGNITAAVADAALAMLDVDPVGFDLMDRKLLEAILHKFDGGPVGVDNLAAAIGEERDTIEDVLEPYLIQQGFLQRTPRGRVATLLTYRHFGLSAPDAANPVRNLWDTPDAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ8</accession>
    <name>Q63QZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome b-561 membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194252.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109470.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2876"/>
    <dbReference type="EnsemblBacteria" id="CAH36886">
        <property type="protein sequence ID" value="CAH36886"/>
        <property type="gene ID" value="BPSL2876"/>
    </dbReference>
    <dbReference type="GeneID" id="56593710"/>
    <dbReference type="KEGG" id="bps:BPSL2876"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2420"/>
    <dbReference type="eggNOG" id="COG3038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LKLYSWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="20374" checksum="C0FA5E6ADC18EE1E" modified="2004-10-25" version="1">MASFSSSASPAAAYTRTAIALHWLIALLIVCGFALGWVMTSIPGFTPAKLKYYSWHKWIGVTVFAIAIVRVLWRATHVPPPMPAGMPAWQRAGAHAVHGLLYVLMLVIPVTGYLYSSAANIPVVYLGLVPLPRLIDPDPALKETLKTAHVLLNYGLLALVAAHVAAAVKHQWFDRDGVLSRMLPFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC4</accession>
    <name>Q63RC4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL2748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186345.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109344.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2748"/>
    <dbReference type="EnsemblBacteria" id="CAH36756">
        <property type="protein sequence ID" value="CAH36756"/>
        <property type="gene ID" value="BPSL2748"/>
    </dbReference>
    <dbReference type="GeneID" id="56594926"/>
    <dbReference type="KEGG" id="bps:BPSL2748"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2568"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIDYQDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="212" mass="23862" checksum="17298439CFD63736" modified="2004-10-25" version="1">MSLRLGDIAPDFEQDSSLGRIKFHEWLGNSWGVLFSHPADYTPVCTTELGLTAKLKGEFEKRNVKVIALSVDSVESHKGWIDDINETQATSVGFPIIADGDRKVSELYDMIHPNANETLTVRSLFVIDPNKKVRLIITYPASTGRNFDEVLRVIDSLQLTDHYKVATPGNWKDGDDVVIVPSLQDPDELKQRFPKGFKAVRPYLRLTPQPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW8</accession>
    <name>Q63RW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109149.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2552"/>
    <dbReference type="EnsemblBacteria" id="CAH36560">
        <property type="protein sequence ID" value="CAH36560"/>
        <property type="gene ID" value="BPSL2552"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2552"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2816"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SCECCRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266741" evidence="1">
        <location>
            <begin position="23"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="423" mass="45665" checksum="AA1A3A81743828BC" modified="2004-10-25" version="1">MVAVRHRLAGVALAAFACGALAHDAQPAAGASSAHAAHMAMDAATAGAAQKTPLATGAAFDARHRLWVAWVEGQHVVVAHSDDAGRTLAPPVTVNALPEPIYTSAENRPKLAASPDGRAIYVTWSMPLDAPYTGMVRFSRSLDGGATWSVPVTVHRDRQAITHRFDMLTIDPQGRIFVAWIDKRDLVAAQRAGRSYDGAAIYYAVSTDGGATFEPERKVSDHTCECCRIAMTVDSDGRVQAAWRNVFPGQIRDHAVAVLHASADRAVEPVRATFSNWHVEACPDHGPALAITADGVRHLAWFGVVDGKADVFYSRLDARGAPLGAPFAFGDDPAAPDEQASHAALVARRDTLWLAWKAFDGDTMRIRLRRSDDGGAHWSAPRTLAWTSGASDNPQLLADRGRVYLSWRTRNDGYRLIDVEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX8</accession>
    <name>Q63RX8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189569.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109139.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2543"/>
    <dbReference type="EnsemblBacteria" id="CAH36550">
        <property type="protein sequence ID" value="CAH36550"/>
        <property type="gene ID" value="BPSL2543"/>
    </dbReference>
    <dbReference type="GeneID" id="56596412"/>
    <dbReference type="KEGG" id="bps:BPSL2543"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2831"/>
    <dbReference type="eggNOG" id="ENOG50330E3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGPMPAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="2">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="25742" checksum="46525D0EB569C510" modified="2004-10-25" version="1">MKRIPFIRGAALVAGALIVLLSGCTSYVTTQVTAFSNWSGNDATRTYAFARTAEQQNSLEQSTYEQIVGNELSTYSFRRVPTKDARYLVRLAYGIKSDWVSVPQPVYYDPWFGPGPYWRGGPWGPFGPWGPFPAGYVNQSYQIFQRSLEIRIAERATGTEVYNVAARNAGEGSSLLQAMPYLARSALADFPLGNGTVRTVRLPVDKNGAPAPMPANERAVPEVPAMPASGAAAAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S70</accession>
    <name>Q63S70_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550135.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109047.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2455"/>
    <dbReference type="EnsemblBacteria" id="CAH36458">
        <property type="protein sequence ID" value="CAH36458"/>
        <property type="gene ID" value="BPSL2455"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2455"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2935"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APMPAGC"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="199"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="432" mass="44528" checksum="DC4ABD1C765167F3" modified="2004-10-25" version="1">MTTHTTPTPSATSGHTVALSVDEARALALRFAERVAQVERVALRDALGRVLAEDVASPFDIPAYDNAAMDGYAFDGAALAAPAADGVLALAVAGRALAGHPFDGPRIAPHACVRIMTGAQMPAGCDTVIPQEKVDATGNVVRFPAAAVARGEHCRRAGEDLARGARALAAGRVVRAADLGLLASLGIAEVAVRRRVRVAFFSTGDELQTPGEPPREGGLYDSNRATLAGMLARIGVETLDLGIVRDDPAALEGALTTAAAQADAVITSGGVSVGDADFTRALLATLGDVTFASVAMRPGRPLACGRIRANGREERPALFFGLPGNPVAVAATFIVIVRDALFAMMGAEAQPLPRYPAVCDAPINKRAGRTEYLRGRAARDASGVWRVAPAGSQSSASLKSLSDANCFIVLAHDAARVDAGTTVDILPFDGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SC6</accession>
    <name>Q63SC6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196953.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108990.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2398"/>
    <dbReference type="EnsemblBacteria" id="CAH36400">
        <property type="protein sequence ID" value="CAH36400"/>
        <property type="gene ID" value="BPSL2398"/>
    </dbReference>
    <dbReference type="GeneID" id="56596310"/>
    <dbReference type="KEGG" id="bps:BPSL2398"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3002"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNWPPAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017834">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00404">
        <property type="entry name" value="hopanetetrol_cyclitol_ether_sy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03471">
        <property type="entry name" value="HpnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="192"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="473" mass="54111" checksum="6C9F7B4F764973BF" modified="2004-10-25" version="1">MKTLFLQAPSYDGFDGGAGSRYQAKREIRSFWYPTWLAQPAALVPGSRVVDAPADGLSVEDTLKIAKDYDLVIIHTSTPSFPTDAMFAEDLKKMKPSMLVGMVGAKVAVDPHNSLTATQAIDFVCREEFDYTCKDIAEGKPFAEILGMSYRAKDGSIEHNGPRPMIENMDELPFVAPVYKRDLKIDNYFIGYLNYPYVSIYTGRGCRSKCTFCLWPQTVGGHRYRVRSVESVLAEVKWIRDNMPEVKEIMFDDDTFTDFKPRVEEIARGLGKLGVTWSCNAKANVPYSTLKIMKENGLRLLLVGYESGDDQILLNIKKGLRTDIARRFNEDCKKLGIKIHGTFILGLPGETKETIKKTIEYAKEINPHTIQVSLAAPYPGTRLYNQAIENGWMEENKTINLVSKEGVQLAAIGYPHLPKEEIYHQLEHFYREFYFRPSKIWEILREMLTSWDMMKRRLREGVEFFRFLRAHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SR1</accession>
    <name>Q63SR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533965.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108855.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2259"/>
    <dbReference type="EnsemblBacteria" id="CAH36262">
        <property type="protein sequence ID" value="CAH36262"/>
        <property type="gene ID" value="BPSL2259"/>
    </dbReference>
    <dbReference type="GeneID" id="56528930"/>
    <dbReference type="KEGG" id="bps:BPSL2259"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2567"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVTNYLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="205" mass="21537" checksum="6ECA7743B8405610" modified="2004-10-25" version="1">MKTPAIEIERVPGAGAHGAATEPSAWVRRWSHLVPAGGAVLDIAAGHGRHAHWFARRGHPVRALEREPAALASLGALPGVRAQAADLEGAPWPLADDARFAAVVVTNYLHRPLLPRLVAAIAPGGVLLYETFAQGNQTVGKPSNPAFLLAPGELLDAVRGQLRVVAFEDGFAAAPREAFVQRICAVREHAAPQEGAGFPRYGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SW8</accession>
    <name>Q63SW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transport system, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535437.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108798.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2203"/>
    <dbReference type="EnsemblBacteria" id="CAH36205">
        <property type="protein sequence ID" value="CAH36205"/>
        <property type="gene ID" value="BPSL2203"/>
    </dbReference>
    <dbReference type="GeneID" id="56528987"/>
    <dbReference type="KEGG" id="bps:BPSL2203"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3244"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VLPKHWW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="140"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="650" mass="71683" checksum="1D4A799E2DE9E99A" modified="2004-10-25" version="1">MTIGSPRARRPRSPQRAAPSEQAARAAAPRRAARARAALARFARRAAAGVALAFVAAPAAHAVYAIAQYGEPKYPAGFAHFDYVNPDAPKGGTLVLANPNRLTTFDKFNPFTMRGNPAPGIDLLFESLTTGSADEPASAYGLLADDIAVAPDGLSVTFHLNPRARFSNGEPVTAADVKYSFDTLKSPKAAPQYPAYYADIARAVIVDAATVRFEFRRKNRELPLIAGGIPVFSRKWGVRADGSRIAFDQIAFEQPIGSGPYLIERYDSGRTITYRRNPAYWGAALPVRIGTNNFERIVYKLYGDGVARLEAFKAGEYDVLVEYIARNWARRDVGKRFDSGELVKREFRQHNGAGMQGFFMNLRRPLFQDVRVRHALDLAFDFEWLNRQLFYGAYTRLNSYFADTDLQATGTPSAGELALLAPLRAQLDPAVFGPMTVQPSTDLPASLRANLLKARALLAEAGWTYRDGALRNAKGEPFVFEILDDSGSAFEPVVAAYIRNLAKLGIVAKYRTADFALLQKRLDAFDYDMTTVRYPGVQVPGAEQVARFASRYADEPGSDNLTGLKSPAVDAILKALTQAETRDELLDATHALDRVLMHGYYAVPQWYSAVHRIAFKRTLAYPSVLPLYYSAEGWVASTWWARPEHGASAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T22</accession>
    <name>LPXD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxD</name>
        <name type="ordered locus">BPSL2149</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521195.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108744.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T22"/>
    <dbReference type="SMR" id="Q63T22"/>
    <dbReference type="STRING" id="272560.BPSL2149"/>
    <dbReference type="EnsemblBacteria" id="CAH36151">
        <property type="protein sequence ID" value="CAH36151"/>
        <property type="gene ID" value="BPSL2149"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2149"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3304"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QIQIAHN"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000059657" description="UDP-3-O-acylglucosamine N-acyltransferase">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <sequence length="361" mass="36768" checksum="8A83B3393FABC14D" modified="2004-10-25" version="1">MALTLEALAARFGGEIVGDGRCEVGALAPLDQAGPRQLAFLANPKYLAQVETTGAGAVLIAPGDLEKLGAAAHGRNFIVTPNPYAYFARVAQMFIDLAAPPRAAGVHPSATIDPAAQVAASAVIGPHVTVEAGAVIGERAQLDANVFVGRGTRIGDDSHLYPNVAIYHGCTLGPRAIVHSGAVIGSDGFGFAPDFVGEGDARTGAWVKIPQVGGVKVGPDVEIGANTTIDRGAMADTVIDECVKIDNLVQIGHNCRIGAYTVIAGCAGIAGSTTIGKHCMIGGAVGIAGHVTLGDYVIVTAKSGVSKSLPKAGIYTSAFPAVEHGDWNRSAALVRNLDKLRDRIKALETALAAREGDAGGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T25</accession>
    <name>LPXB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="1">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxB</name>
        <name type="ordered locus">BPSL2146</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxB family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205135.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108741.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T25"/>
    <dbReference type="SMR" id="Q63T25"/>
    <dbReference type="STRING" id="272560.BPSL2146"/>
    <dbReference type="PRIDE" id="Q63T25"/>
    <dbReference type="EnsemblBacteria" id="CAH36148">
        <property type="protein sequence ID" value="CAH36148"/>
        <property type="gene ID" value="BPSL2146"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2146"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3307"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00392">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000255165" description="Lipid-A-disaccharide synthase">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00392"/>
        </source>
    </evidence>
    <sequence length="388" mass="42147" checksum="78753260D4CD3AA2" modified="2004-10-25" version="1">MAFQLTPLRVALVAGEPSGDLLGASLLGGLHARLPASSRYYGIGGPRMSAVEFDAHWPMEKLAVRGYVEALKHIPEILRIRGELKRQLLAEPPDAFVGIDAPDFNFGLEQALRGAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFEPELLEKAGVAATFVGHPLADEIPLEPDTHGARIALGLPDGGPVIAVLPGSRRSEIELIGPTFFDAMELMQQREPGVRFVVPAATPVLRALLQPLVDAHPSLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPDALADATLTQLRDDANRRALTDIFTDMHLALRQNTAQRAAEAVARVIDSRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T48</accession>
    <name>Q63T48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108718.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2121"/>
    <dbReference type="EnsemblBacteria" id="CAH36124">
        <property type="protein sequence ID" value="CAH36124"/>
        <property type="gene ID" value="BPSL2121"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2121"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2407"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNRSHCS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="25506" checksum="3ADAE90446D54BCD" modified="2004-10-25" version="1">MRTMTKKDAAPTGASAESIAERIRTAILEHRLAPGTKLTEAQLCEVFGVKRGAIRQALALLATDRLVDLEPNRGAFVASPTLQDVHEVFEMRRIVELAVMERLATGPGAKRLKGVAAMIDKERHAFERRDFPAWIRLSGEFHTALAALTGNTVLRDCLGGLVARSTLMSALYESHGRSPCSFDDHAQILAALEAGDAKRAAQLMAHHLQHVELKMLDRPAQGAVDLREVFGDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T61</accession>
    <name>Q63T61_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108705.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2108"/>
    <dbReference type="EnsemblBacteria" id="CAH36111">
        <property type="protein sequence ID" value="CAH36111"/>
        <property type="gene ID" value="BPSL2108"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2108"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2391"/>
    <dbReference type="eggNOG" id="ENOG50315NX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYEADGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="18331" checksum="BEDAD70D01F28259" modified="2004-10-25" version="1">MGRMRMPHFLQLFLRRVFMSFPKKRRRAQPDGQESFLAVLRHAKPFAQLDTKIARARAQDEPVLYAHVLPGLDVLLCSVRGAQPPYPAIAELRKRCIESIANALEQPLDGLENGGYWYEANGFGFLVFASRARARILPEFGAGVKAGLRSGIGQPNAGDTTPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TB0</accession>
    <name>Q63TB0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538398.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108656.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2057"/>
    <dbReference type="EnsemblBacteria" id="CAH36058">
        <property type="protein sequence ID" value="CAH36058"/>
        <property type="gene ID" value="BPSL2057"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2057"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.44"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATRCENC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267122" evidence="5">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="43"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="16835" checksum="FDFB84825F470FF3" modified="2004-10-25" version="1">MSIASPVRPPRRRVARALVLAAFVALAALGGTARASPDDARAARAARGARLFDGSDPMHGRLAGHAQVLPSTASRCANCHQPPAPRATPALAPPLDASSLLAPQKRRGGPPSAYTADSFCATLRSGIDPAHVTLKAAMPRYDATDAQCADLWAFLIPIPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TI2</accession>
    <name>Q63TI2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192096.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108584.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1986"/>
    <dbReference type="EnsemblBacteria" id="CAH35985">
        <property type="protein sequence ID" value="CAH35985"/>
        <property type="gene ID" value="BPSL1986"/>
    </dbReference>
    <dbReference type="GeneID" id="56595411"/>
    <dbReference type="KEGG" id="bps:BPSL1986"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4138"/>
    <dbReference type="eggNOG" id="ENOG5030X3X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAWAASQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="14483" checksum="66D16F36A41FF3B6" modified="2004-10-25" version="1">MLFRSGTIRIPFEPNDKARERERPIQRVELDPEHDRHARAALEAYADSSAHEMPWLAEWMREALGSPQPELTRCAQTVERVFDLAHAWAAGQPDYAGAAWEHVRGRLLEALQHAPRAIAPDALETDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TL3</accession>
    <name>Q63TL3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scoA</name>
        <name evidence="3" type="ordered locus">BPSL1955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192091.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108553.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1955"/>
    <dbReference type="EnsemblBacteria" id="CAH35954">
        <property type="protein sequence ID" value="CAH35954"/>
        <property type="gene ID" value="BPSL1955"/>
    </dbReference>
    <dbReference type="GeneID" id="56595497"/>
    <dbReference type="KEGG" id="bps:BPSL1955"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4100"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FVKAWKG"/>
    <dbReference type="BRENDA" id="2.8.3.5">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="25218" checksum="40E63270E064C75C" modified="2004-10-25" version="1">MNKVYPSAAAALEGVVHDGQTFAVGGFGLCGIPEALIAALRDSAVKGITCISNNAGVDGFGLGLLLETRQIKKMISSYVGENKEFERQYLSGELELEFTPQGTLAEKLRAGGAGIPAFFTQTGYGTVIAEGKETREFDGKHYVLEPSLTADVALVKAWKADKSGNLVYRRTARNFNPMCAMAGRITIAEVEEIVENGELDPDAIHTPGIFVQRLVLNATPEKRIEQRVVRAKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TL8</accession>
    <name>Q63TL8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550568.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108548.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1950"/>
    <dbReference type="EnsemblBacteria" id="CAH35949">
        <property type="protein sequence ID" value="CAH35949"/>
        <property type="gene ID" value="BPSL1950"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1950"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2198"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFMVRYP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="301" mass="32759" checksum="7122AA2B79E9AC24" modified="2004-10-25" version="1">MLIDDLPALATFARIVAAGSLSAAARELDLSLSVVSKRLAQLETRLGVRLLQRTTRQQTLTDEGALFHAQVVRILAEIEQAESLMRERRGTVSGALRITAPGELGRRRIAPIVAAFQRQHPQVTVQMQLTDAVVDLIAHDVDVAVRIGMLADSSLIARELAPNYRVLCASPAYLAEHGMPAQPADLCAHRCIVLGEQPRVEWRFDGSHPAAVEVSAAFLTNDGGAARTLALEGAGIALKSIWDVGPDLAAGRLRRVLPECASSAAPLHAVYPSGRHLALRVRTFVDYLGVELRRAWRWDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TQ5</accession>
    <name>Q63TQ5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ordered locus">BPSL1911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193111.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108511.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1911"/>
    <dbReference type="EnsemblBacteria" id="CAH35911">
        <property type="protein sequence ID" value="CAH35911"/>
        <property type="gene ID" value="BPSL1911"/>
    </dbReference>
    <dbReference type="GeneID" id="56595452"/>
    <dbReference type="KEGG" id="bps:BPSL1911"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4055"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="608" mass="67498" checksum="1B6287B4CC0371D8" modified="2004-10-25" version="1">MTRALRNIAIIAHVDHGKTTLVDQLLRQSGTFRENQQVAERVMDSNDIEKERGITILAKNCAVEYEGTHINIVDTPGHADFGGEVERVLSMVDSVLLLVDAVEGPMPQTRFVTKKALALGLKPIVVINKIDRPGARIDWVINQTFDLFDKLGATEEQLDFPIVYASGLNGYASLDPAARDGDMRPLFEAILQHVPVRPADPDAPLQLQITSLDYSTYVGRIGVGRITRGRIKPGQPVVMRFGPEGDVLNRKINQVLSFQGLERVQVDSAEAGDIVLINGIEDVGIGATICAVEAPEALPMITVDEPTLTMNFLVNSSPLAGREGKFVTSRQIRDRLMKELNHNVALRVKDTGDETVFEVSGRGELHLTILVENMRREGYELAVSRPRVVMQEIDGVKHEPYELLTVDLEDEHQGGVMEELGRRKGEMLDMVSDGRGRTRLEYRIPARGLIGFQSEFLTLTRGTGLMSHIFDSYAPVKEGSVGERRNGVLISQDDGAAVAYALWKLQDRGRMFVKPGDALYEGMIIGIHSRDNDLVVNPIKGKQLTNVRASGTDEAVRLVPPIQMSLEYAVEFIDDDELVEVTPQSIRLRKRHLKEHERRRASREAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU2</accession>
    <name>Q63TU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538333.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108474.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1875"/>
    <dbReference type="EnsemblBacteria" id="CAH35874">
        <property type="protein sequence ID" value="CAH35874"/>
        <property type="gene ID" value="BPSL1875"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1875"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4011"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHEIMAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="254"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="316"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="570" mass="61687" checksum="9280890AF3AB4EB5" modified="2004-10-25" version="1">MGFLNTFSLRRYASLLLGLLAVAAVAIGLCQWRLDAANHRVAQAYQQRYVSTQLANELRRSSDDLTRLARTYVATGDAKWEQQYNEILAIRSGKAPRPLDYDRIYWDFRAADEPLRAEQGETISLQEMMKRAGFTDEEFAKLHDAEQNSNDLVKTETVAMNLVKGLTPDDAGHFTKQGSPDLEKARALMFDANYHRFKAKIMHPIDDFLKLLDARTEGAIARAQASAQTWKIISAAVAIGILAFFALMLHMMFKRVLAGLEAAASTASRVAAGDLTSHFDAHRVDPQAKDEISRVMRALQTMNDGLVRIVTDVRSGTDTIATASHEIMAGNNDLSARTEQQAASLQETAASMSELTATVKLNLENARQANMIGSNAVSTVEKGSVSVEQLVTTVNAISTNSGKIADIISLIEGIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSLAQRSSSAAKEIKDLIETSIDTVRDGVSKADEVGQHIVEVKQAIRRVADLVGEITAASEEQTRGIEQVDAAVSQMDRVTQQNAALVEQAAAASKAMDDQAGNLRAAASIFKLPGRASLFAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TY8</accession>
    <name>Q63TY8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108428.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1829"/>
    <dbReference type="EnsemblBacteria" id="CAH35828">
        <property type="protein sequence ID" value="CAH35828"/>
        <property type="gene ID" value="BPSL1829"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1829"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2061"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGDINQS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035440">
        <property type="entry name" value="4HB_MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003122">
        <property type="entry name" value="Tar_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02203">
        <property type="entry name" value="TarH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47170">
        <property type="entry name" value="SSF47170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="276"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="634" mass="65636" checksum="24DEFF0EE17A9817" modified="2004-10-25" version="1">MRRLTGRTMLLKNITIRARLAVTMALLSVLLCAVGALGLFGMSRANDANEQTSSNQLPSAIDVASAELFAARERLVLDRAALLAGTPDVAPTIERARQMRGVSDSWWKKYLDLPRDAQEDRLAQDLASKRQILQRELDAAAALINANDRDRILESAKRMQNVFNDFSLASEALRAFQLKQASVNFSDAQSVYAASRVASIAALALGLALSLYCFLSLRAAIARPLADALGHFDAIAAGELRRPIVVERRDEMGLLLEGLAKMQASLAGTVRAVRVGSESIATAARQIAAGNIDLSSRTEEQAAALEQTASSMEELTGTVRRNADNARQASALAASASEIANKGNAVVGQVVGTMGDINQSSAKIADIITIIEGIAFQTNILALNAAVEAARAGEEGRGFAVVAGEVRSLAQRSSTAAKEIKELIDTSVERVRTGSMLVDDAGRTMSEVIGAVRRVTDIMGEIAAASDEQSTGIDQVSRAVSQMDEVTQQNAALVEQAAAAAQSLDEQAARLRATVSVFHVDDGDARDVASRPPARPGAGAVHRAAGAAAPAQAGASSGAHAAPAAHAARKPAPSAALAKAAPVASVASAASVTPAAPAPTLAAAAATPKPAPAAPRAGSVTAASAASDDDWETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TZ2</accession>
    <name>Q63TZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526907.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108424.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1825"/>
    <dbReference type="EnsemblBacteria" id="CAH35824">
        <property type="protein sequence ID" value="CAH35824"/>
        <property type="gene ID" value="BPSL1825"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1825"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3948"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THTNDPT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004736">
        <property type="entry name" value="MHS_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00883">
        <property type="entry name" value="2A0106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="434" mass="46727" checksum="34060A195B72637E" modified="2004-10-25" version="1">MNDQTAVAAAARQDVRRRVLAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQLLNTAGVFAAGFLMRPIGGWLFGRIADKHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGALAPLLLLVARLFQGLSVGGEYGTSATYMSEVALQGRRGFFASFQYVTLIGGQLCALLVLVILQQTLSSDALKAWGWRIPFVVGAAAALISLYLRKSLDETSTSESRKAKDAGTIRGVWQHKGAFLTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTAALFVYMLMQPMFGALSDKIGRRMSMILFGTGAVIGTVPLMHALGGVTSPLAAFGLIVVALAIVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSVGSESSFYWYVTVLCAISLLVSWRMRDPSREGYLRNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UH4</accession>
    <name>Q63UH4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative fimbrial usher protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL1628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell outer membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the fimbrial export usher family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108242.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63UH4"/>
    <dbReference type="STRING" id="272560.BPSL1628"/>
    <dbReference type="EnsemblBacteria" id="CAH35627">
        <property type="protein sequence ID" value="CAH35627"/>
        <property type="gene ID" value="BPSL1628"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1628"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1836"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHARTEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018030">
        <property type="entry name" value="Fimbrial_membr_usher_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025949">
        <property type="entry name" value="PapC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043142">
        <property type="entry name" value="PapC-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025885">
        <property type="entry name" value="PapC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037224">
        <property type="entry name" value="PapC_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13953">
        <property type="entry name" value="PapC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13954">
        <property type="entry name" value="PapC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141729">
        <property type="entry name" value="SSF141729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01151">
        <property type="entry name" value="FIMBRIAL_USHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="10" id="KW-1029">Fimbrium biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266788" evidence="11">
        <location>
            <begin position="31"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="PapC_N" evidence="13">
        <location>
            <begin position="37"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PapC_C" evidence="12">
        <location>
            <begin position="769"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="850" mass="90635" checksum="311BCE7FF761292C" modified="2004-10-25" version="1">MIRHRVADVGFSRIRVTMLAAALTALSATARGQQALEFDPAFLELGGGQGGADLSVYATSNRVLPGVYPISVFVNGEAIERRDITFVSESARDGREDAIPCLSARMFDEWGVDIAAFAKLAQAGEDACVDIADSVPHARTEFDSHQLRLNVTVPQAALKRRARGAVDPARWDQGIDAALLDYQLSAAQYAGGNFASARSRTTLYAGLRGAVNLGAWRLSHTSSFLRGLDGRNRFQIVNTFVQRDIAGWNSRLTAGEGTTPANIFDGFQFLGVQLNTDETMLPDSLQGYAPTVHGVAQTNAQVTIRQNGFVIYSTYVPPGPFTIDDLYPTSSSGNLEVTITEADGHVTTFTQPYSAVPMLLRDGSWRYNVTAGQYRDGISGSHPSFAMATLARGLAGEFSLYGGFIGAGMYQSVLVGIGKNLGSIGAVSLDVTHARSAVDLADSSTVSGHAFRVLYAKAVGSWGTDFRLLAYRYSTAGYRSFADAVQLRDGSEPAALGAKRQRLEGTVNQRLGRLGSMYATVAVQTYWGSAARSTVYQLGHSGNWGRASYGLYAAYSKGSGVPSSWNVSLSLSMPLEVFFGGARVRAPAGGSANVSYFVSRNNENHVNQQMTASGSSSEQRLNYSVGVAHSSESDVSGSVSASYLAPFGRYDASIGSGRGYTQAAFTAAGGMLWHGTGVLFTQPLGETVAVVDVPNVRGVRFEMHPGVSTDRAGEAVIPRLNPYRVNRIAVDQRRMPQDVEIRNPVSEVVPTRAAVVQTHFDSVVGLRALFTLMRADGSFPPQGATAENDEGQVLGVVGMDGETFVAGLPAAEGHFVVRWGAARQNRCRVNYALPGKAAIGAYLAVEAICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UI8</accession>
    <name>Q63UI8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108228.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1612"/>
    <dbReference type="EnsemblBacteria" id="CAH35612">
        <property type="protein sequence ID" value="CAH35612"/>
        <property type="gene ID" value="BPSL1612"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1612"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3672"/>
    <dbReference type="eggNOG" id="ENOG5032XC9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAWRTND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="17255" checksum="2CF6C53F6F102801" modified="2004-10-25" version="1">MKTNGKRPMPLFLQGVVSEAGYARGLLREAQAHVVRGRRRGMSATGAQYRDAIHAAVVASGGFDGCTGEPLDWHLVSTDANDDSRPGRHSYKAGFALLPSVDHVDASAAAAAFKVRAWRMNDAKSGLSARSFIALRERVLMHAGYRVHAPNDAKGLDASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UX3</accession>
    <name>Q63UX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL1473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192320.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108093.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1473"/>
    <dbReference type="EnsemblBacteria" id="CAH35474">
        <property type="protein sequence ID" value="CAH35474"/>
        <property type="gene ID" value="BPSL1473"/>
    </dbReference>
    <dbReference type="GeneID" id="60549345"/>
    <dbReference type="GeneID" id="66547325"/>
    <dbReference type="KEGG" id="bps:BPSL1473"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3504"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGEMIGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="123" mass="13127" checksum="4D9DC6A1E6DB9861" modified="2004-10-25" version="1">MNPVSLFCIVTGVMLNACAQLLLKAGVRAVGHFEFTRANIVPIGFKIATQLPIIGGLGCYVLSVVVWIVGLSRVDVSVAYPMLSLGYVVNAFAAWYLFGEVLSVQRLVGIGIILIGVFVLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V15</accession>
    <name>Q63V15_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193935.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108051.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1429"/>
    <dbReference type="EnsemblBacteria" id="CAH35431">
        <property type="protein sequence ID" value="CAH35431"/>
        <property type="gene ID" value="BPSL1429"/>
    </dbReference>
    <dbReference type="GeneID" id="56595835"/>
    <dbReference type="KEGG" id="bps:BPSL1429"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3450"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SATIECK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="50"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17003" checksum="7BAB867608654F85" modified="2004-10-25" version="1">MSDACATAGREPAIESPFVDALGVRLVSAKDGASEIVLPLAEQHMNTWNIAHGGVTMTLADVALAMAARSLTDDGVGVVTVEMKVNFMQPGRGELRAYGRVLHRSTTMAYCEGEVRDSAGNFVAKALGTFKYMKRLAVGRDIARQRTRTDPGAHPGPSDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V24</accession>
    <name>YCIB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inner membrane-spanning protein YciB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yciB</name>
        <name type="ordered locus">BPSL1420</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192037.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108042.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V24"/>
    <dbReference type="STRING" id="272560.BPSL1420"/>
    <dbReference type="EnsemblBacteria" id="CAH35422">
        <property type="protein sequence ID" value="CAH35422"/>
        <property type="gene ID" value="BPSL1420"/>
    </dbReference>
    <dbReference type="GeneID" id="56595844"/>
    <dbReference type="KEGG" id="bps:BPSL1420"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3439"/>
    <dbReference type="eggNOG" id="COG2917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWVNFKL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00189">
        <property type="entry name" value="YciB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006008">
        <property type="entry name" value="YciB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36917">
        <property type="entry name" value="PTHR36917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04279">
        <property type="entry name" value="IspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00997">
        <property type="entry name" value="ispZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000020998" description="Inner membrane-spanning protein YciB">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00189"/>
        </source>
    </evidence>
    <sequence length="176" mass="20017" checksum="A423ABA58873351C" modified="2004-10-25" version="1">MKFLFDLFPIILFFAAFKLWGIFTATAVAIAATLAQVAWVAFRHRKVDTMLWVSLGVIVVFGGATLVLHDEKFIQWKPTVLYWLFAVGLVAARYAFGKNLIEKMMGKQLTLPEPVWDKLNLAWAAFFAALGVTNLYVVRNFTESQWVNFKLFGTTGAIVVFVILQSLWLAKYLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD3</accession>
    <name>Q63VD3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521852.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107933.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35306">
        <property type="protein sequence ID" value="CAH35306"/>
        <property type="gene ID" value="BPSL1309"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1309"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.183"/>
    <dbReference type="eggNOG" id="COG2808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARANPQW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PTHR35802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="212" mass="23259" checksum="7AF3D6798431D188" modified="2004-10-25" version="1">MYVPAHFEENRTDALHALIAQHPFGILVTHGDGGLDANHIPFELAPGEGPLGVLRAHVARANPVWQQVSDGDEVLAVFRAGDAYISPNWYPSKHELHRQVPTWNYVVVHAHGRIAVRDEASFVRGVVARLTRTHEAAQPVPWKIGDAPRDYIDTMLQAIVGLQIDITRLVGKCKLGQNKDARDIRGAGQALKARGDDAIGDRMLAKAAEKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VE1</accession>
    <name>Q63VE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535535.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107925.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1303"/>
    <dbReference type="EnsemblBacteria" id="CAH35298">
        <property type="protein sequence ID" value="CAH35298"/>
        <property type="gene ID" value="BPSL1303"/>
    </dbReference>
    <dbReference type="GeneID" id="56526554"/>
    <dbReference type="KEGG" id="bps:BPSL1303"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.197"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWADWAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267614" evidence="1">
        <location>
            <begin position="42"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="38273" checksum="0CF6A2F9FBD79E4A" modified="2004-10-25" version="1">MTVRRSLLPRSPLAAVRRACAAMLIPVASLALSLGASAAHAQDTAICYNCPPEWADWAAQIAAIKQRTGIRVPFDNKNSGQAIAQLIAEQKSPVADVVYLGVSSAFQAKDKGVVAPYKPAHWSDIPANLKDPQGYWFAIHSGTLGFFVNKDALDGKPVPRTWADLLKPEYKGMVGYLDPSSAFVGYAGAVAVNQALGGSFDDFRPALDWFRKLKANQPIVPKQTAYARVLSGEIPILLDYDFDAYRAKYKDHANVEFVIPKEGTISVPYVMSLVKGAPHEANGRKVLDFVLSDEGQKLWASAYLRPVRAQALGADVAAQFLPASEYARAKSVDFGKLAAGQQAFGKQYLQAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF2</accession>
    <name>Q63VF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204980.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1292"/>
    <dbReference type="EnsemblBacteria" id="CAH35287">
        <property type="protein sequence ID" value="CAH35287"/>
        <property type="gene ID" value="BPSL1292"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1292"/>
    <dbReference type="eggNOG" id="COG5429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPIDYWD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010634">
        <property type="entry name" value="DUF1223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057">
        <property type="entry name" value="PTHR36057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06764">
        <property type="entry name" value="DUF1223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266618" evidence="1">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="28847" checksum="79D14F4BE837E86E" modified="2004-10-25" version="1">MSTDMSISFSVSLRAVAAALSLAAAGAAQAAADGACMARSPDGRQALVELYTSEGCSSCPPADDWLARLAARRAALRVVPLALHVDYWDGLGWADRFAQHRFTERQHALAARGGGRFVYTPEVAVDGRELRDWRDADAFGRRVVATAAAPARVGIALAAKRRAGALDVALSVTPRVGAPRALDAYLALYENGVESQVSAGENRGATLRHERVVRQWIGPLAATADAHASLDVRRALPLPANLRAADAARYGVAAFVEDPATGDVLQALDLPLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VJ4</accession>
    <name>Q63VJ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107872.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1251"/>
    <dbReference type="EnsemblBacteria" id="CAH35245">
        <property type="protein sequence ID" value="CAH35245"/>
        <property type="gene ID" value="BPSL1251"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1251"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.272"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HACIPND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17117" checksum="630319CDABA0EF32" modified="2004-10-25" version="1">MQFEELSDDEWARIEGLLAAQPVRNTRCGRPRAQARAVANAVLWVLTTGECWAALPRRYPSSPTCRRRFDEWSADGTLAALIERLRGAGRQVELRERIGAIDAKPHARARRRFQHNAFWSSPESWCAPAVAVVGGVIEAGRDDCVPEHGEGNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VW4</accession>
    <name>Q63VW4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198106.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107752.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63VW4"/>
    <dbReference type="STRING" id="272560.BPSL1130"/>
    <dbReference type="EnsemblBacteria" id="CAH35124">
        <property type="protein sequence ID" value="CAH35124"/>
        <property type="gene ID" value="BPSL1130"/>
    </dbReference>
    <dbReference type="GeneID" id="56595079"/>
    <dbReference type="KEGG" id="bps:BPSL1130"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.418"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRWMGAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="33624" checksum="F1C6A5219E46A2A2" modified="2004-10-25" version="1">MTETSRPAPSDEPFAALRPRLFSIAYRMLGTRADAEDVLQDAWLRWHQAERDTLDSPEAWLVTVVTRLSIDRLRAAKAQRDAYVGWWLPEPLVDIDERTPEAAAEFADDLSVALLWVLERLSPEERAAFLLRQAFERDYAEIAQLLDKSEAACRQLVHRASTRVQQEHRRFDVSRERHRQLVERFARAAASGERNAIRALLADDVELVGDGGGKVPSFFKVLRGALRIANLYWAVGRRHAGQIEYRLAQINGEPGLLRFIDGRIESAQAFATDGARIVAIYAVRNPDKLAHIPNRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W13</accession>
    <name>Q63W13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phenazine biosynthesis-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526401.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107703.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1081"/>
    <dbReference type="EnsemblBacteria" id="CAH35075">
        <property type="protein sequence ID" value="CAH35075"/>
        <property type="gene ID" value="BPSL1081"/>
    </dbReference>
    <dbReference type="GeneID" id="56526760"/>
    <dbReference type="KEGG" id="bps:BPSL1081"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1174"/>
    <dbReference type="eggNOG" id="COG0384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHAWLQA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="30691" checksum="55B454252C51C695" modified="2004-10-25" version="1">MAAARRAAHTVRFKQVDVFTSVPFKGNPLAVVFDADALSDADMLAIARWTNLSETAFLVAPSDPAADYRVRIFTTGGELPFAGHPTLGAAHAFLDAGAQPKAPGRLVQQCGAGLVELAKRDGGWAFAAPSARVTPLAEREWPALAAALRTGAIDFGVPPRAVDNGAPWLVVRLASAADCLALAPDHAALAPIVAALGAAGLAAYGPHPADGPATFEVRCLMTGDAFGAAGEDPVTGSANAAIAGVLAQAGRRPGRRYTARQGTVLGRDGRISVDYDDDAGKIWIGGAAVTLVDGTIRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W45</accession>
    <name>Q63W45_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="5 9">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Osmoregulatory trehalose synthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">otsA</name>
        <name evidence="10" type="ordered locus">BPSL1044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="5 9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192381.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107671.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1044"/>
    <dbReference type="EnsemblBacteria" id="CAH35040">
        <property type="protein sequence ID" value="CAH35040"/>
        <property type="gene ID" value="BPSL1044"/>
    </dbReference>
    <dbReference type="GeneID" id="56596145"/>
    <dbReference type="KEGG" id="bps:BPSL1044"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.520"/>
    <dbReference type="eggNOG" id="COG0380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPLCHIA"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="472" mass="52776" checksum="63AED6F8DC99A65A" modified="2004-10-25" version="1">MSRLIVVSNRVAAGQDARPTAGGLAVGVLDALKETGGVWFGWNGEIAGAPEEPVIERDGNVTYATVGLTRRDYDQYYRGFSNATLWPVFHYRGDLARFDRQEYAGYLRVNCALAKQLCALVQPDDIIWVHDYHLLPFAHCLRELGVKNPIGFFLHIPFPSPEVLRTVPPHEELMKFMCAYDVIGLQTESDKQAFVDYIERRGLGTSSEDGILHAHGRVVKVAAYPIGIYPDAIGKAAIEYGSRKAVKALRDTMRERKLVISVDRLDYSKGLVERFQAFERMLANAPGWQGRVSLVQIAPPTRSDVQTYQRIRQTLEGEAGRINGRFAQLDWTPIQYLNRKYERNLLMALFRLSQVGYVTPLRDGMNLVAKEYVASQDPNDPGVLVLSEFAGAAAELPGALLVNPFDLSQMAESLERALAMPLEERQARHAENIARLRKNDLSVWRDSFLTDLRSVATAASVTQRAGRRVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WC1</accession>
    <name>Q63WC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193769.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107595.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0967"/>
    <dbReference type="EnsemblBacteria" id="CAH34963">
        <property type="protein sequence ID" value="CAH34963"/>
        <property type="gene ID" value="BPSL0967"/>
    </dbReference>
    <dbReference type="GeneID" id="56596225"/>
    <dbReference type="KEGG" id="bps:BPSL0967"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.610"/>
    <dbReference type="eggNOG" id="ENOG502ZRZT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETEVMEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018924">
        <property type="entry name" value="DUF2486"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10667">
        <property type="entry name" value="DUF2486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="24005" checksum="55E19D7B34F3FC79" modified="2004-10-25" version="1">MVEANASSIPVLTDVLVPGNPALARPPAAGPAQAGEPAAAAIRAGEGHDADRRDEATATEPAAVVAAAAAAAPAARDAALAPADEMRAPAPAEPSFALPAPDPLAVELPTAYPADATYADELPAAHPAPDLTPPAALPSSVPELAQAAPSFAADLEARQIAERLKSRMTRYLTGEGRGLIEARCRDALHDHAGWLVGQIAREVALALETEVAGWVTEEVGAALARRNAPARSDTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WE8</accession>
    <name>Q63WE8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DeoR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107568.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0939"/>
    <dbReference type="DNASU" id="3094598"/>
    <dbReference type="EnsemblBacteria" id="CAH34935">
        <property type="protein sequence ID" value="CAH34935"/>
        <property type="gene ID" value="BPSL0939"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0939"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHLFTWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="38901" checksum="9D4194CB19FB06BC" modified="2004-10-25" version="1">MCAANMSEGRVSKENAERIHKIVQRIRKCGAVTIAELMVHLEVSRATLKRDFDVLRDRLGCPLVWDKRKRGYVIEDGQLPGGGPFELPGLWFSSSEVHALLAMLHLVQGVQPGLLEEHIGPLKARLREMLGQGAYSAKSIDRRVKLIHFANRKLDARNFQLLAGAVLDRKRLCIRYWNREKHEATEREISPIQLVHYRENWLLDAWCHARDALRSFSLESIESAYVVDKVAIEVDESTMAEHFQGGYGIFAGKARHTARLKFSAQRAQWVSQEVWHEKQTSKWLEDGSYLLEVPYSNDQELLMDLLRHGDQVEVLGPPEFRARMFAILCAAAEKYRTDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WF3</accession>
    <name>Q63WF3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526296.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107563.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0935"/>
    <dbReference type="EnsemblBacteria" id="CAH34930">
        <property type="protein sequence ID" value="CAH34930"/>
        <property type="gene ID" value="BPSL0935"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0935"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.645"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CWKLNDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="YiiM-like_3-alpha_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="25779" checksum="3D13B32B28174916" modified="2004-10-25" version="1">MHPTTAKLDALLTGAIRPLAGTARTSAIDKQPVRERSWLARTGFAGDEQADRKHHGGPDKAVHHYAFDHYPQWIAEIGPRDVLARPGAFGENLSTRGVTERDVCVGDVFTLGGATLQVSQSRQPCWKLNARFGLPKMSARVQQSGRTGWYYRVLDEGWVEPDAELALRERPYPQWPLSNVLDVLYRRTLDVGALEALSRIDALPPSWRQLFERRLKAGAVEDWTKRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WF6</accession>
    <name>Q63WF6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522591.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107560.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0932"/>
    <dbReference type="EnsemblBacteria" id="CAH34927">
        <property type="protein sequence ID" value="CAH34927"/>
        <property type="gene ID" value="BPSL0932"/>
    </dbReference>
    <dbReference type="GeneID" id="56526886"/>
    <dbReference type="KEGG" id="bps:BPSL0932"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.648"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQRLYEV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="320" mass="35223" checksum="56E7012CB6467630" modified="2004-10-25" version="1">MREVNRFSEMAVFVQVIESCGFSAAGRRLDMTPSAISKFVQRLETRLGVRLLNRTTRKLQLTPEGAAFYERCVRILEDIADAEREATHGATPQGRVRINSHVPFGKHHLMPLLPEFQRRYPDITLDIVLSDSLVDPLDERSDIAIRSGALDDSRLVMRKLGGSRMVVVGAPAYLERNGVPATPDDLDRHNCIGLSGNAKAWPFVAEEGQRLLPSAGNLLLGDNESIREAAVSGLGLARLARFHVDADLDAGRLVPVLEAFNPGDEEEINAVFVGPSEHLPMRVHALLDFLKERIRIGPRAAGERGEASALGARAFVTRLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WH4</accession>
    <name>RL33_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmG</name>
        <name type="ordered locus">BPSL0915</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185395.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107542.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WH4"/>
    <dbReference type="SMR" id="Q63WH4"/>
    <dbReference type="STRING" id="272560.BPSL0915"/>
    <dbReference type="EnsemblBacteria" id="CAH34909">
        <property type="protein sequence ID" value="CAH34909"/>
        <property type="gene ID" value="BPSL0915"/>
    </dbReference>
    <dbReference type="GeneID" id="60547006"/>
    <dbReference type="GeneID" id="64460369"/>
    <dbReference type="GeneID" id="67432132"/>
    <dbReference type="KEGG" id="bps:BPSL0915"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.667"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GTGFYYT"/>
    <dbReference type="PRO" id="PR:Q63WH4"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000115117" description="50S ribosomal protein L33">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="55" mass="6356" checksum="E8AE1CA0B307F1AB" modified="2004-10-25" version="1">MAKGARDKIKLESTAGTGHFYTTTKNKRNMPEKMEIMKFDPVARKHVAYKETKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X40</accession>
    <name>Q63X40_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative periplasmic cytochrome c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="4">Binds 2 heme c groups covalently per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556719.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107326.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0697"/>
    <dbReference type="EnsemblBacteria" id="CAH34690">
        <property type="protein sequence ID" value="CAH34690"/>
        <property type="gene ID" value="BPSL0697"/>
    </dbReference>
    <dbReference type="GeneID" id="56527092"/>
    <dbReference type="KEGG" id="bps:BPSL0697"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.760"/>
    <dbReference type="eggNOG" id="COG2863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TACHGEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024167">
        <property type="entry name" value="Cytochrome_c4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000005">
        <property type="entry name" value="Cytochrome_c4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266648" evidence="8">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="9">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000005-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000005-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="253" mass="27151" checksum="6E88AAD4504927C5" modified="2004-10-25" version="1">MESRVSSRRLFRPLLAVVLMGAAGLLSTAHAQTKPTEPAAAKAPLKAPDTMAERVRGCTACHGTHGQGTDNDYFPRLAGKPAEYLYNQLVNFRDGRRKYPPMNYLLTYLSDDYLREIAQHFSDERPPYPAPTKPTVPAAVVERGKQLALHGDPARKLPACVACHGNGLTGMQPAIPGLVGLHSDYLSAQIGAWRSGTRHAKAPDCMHDVASKLSDEDVTAVTAWLAAQPAPANPVPAPARSMKTPLACGSEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XF9</accession>
    <name>Q63XF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204830.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107206.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0578"/>
    <dbReference type="ESTHER" id="burps-q63xf9">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34570">
        <property type="protein sequence ID" value="CAH34570"/>
        <property type="gene ID" value="BPSL0578"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0578"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1065"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRCPVWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="22"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="243" mass="25874" checksum="8E7D5307C9AC22EC" modified="2004-10-25" version="1">MGTRSIAYDCGGARLTGYFADDAPNTKKPAVLIAHEAFGLNEHIRARARRLAELGYAAFALDMYGAEGFPMPEAIRRHIELMSTPGLMHARASAALSVLMEQPGVDRERVAAIGFCQGGISALELARGGAPIRCAVGFHPGLMRPAGSQDGPIRAKVLMMIGARDPDVPAADQAAFAAEMQEKQVDWQLHLFGGVGHAYTNPDADGWNKPGYGYSRAADQRAWTMMLALFDEVFGGAAAVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XS3</accession>
    <name>Q63XS3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195349.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107092.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0466"/>
    <dbReference type="EnsemblBacteria" id="CAH34455">
        <property type="protein sequence ID" value="CAH34455"/>
        <property type="gene ID" value="BPSL0466"/>
    </dbReference>
    <dbReference type="GeneID" id="56594497"/>
    <dbReference type="KEGG" id="bps:BPSL0466"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1189"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NYFQHRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00363">
        <property type="entry name" value="TIGR00363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266657" description="Lipoprotein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="272" mass="29071" checksum="1BC11C4481FCD248" modified="2004-10-25" version="1">MKRRTLLKVVSAVAAGAAALSVSVGAQAQDKVIKVGTVAGPDAQVWQVVQKVAKEKQGLDVKVIEFNDYVQPNAALDSGDLDANSFQHQPYLDSQVKQRGYKIVSAGLTYISPIGVYSKKFKSLKELPAGAKVALPNDPSNENRALLLLQTQGVIKLKAGAGTGGSNATVLDVAENPKKLKLTELDAAQLPRVLSDVDAAVINTNYALAANLQPTKDAIALESLTSPYANLIAVRAKDKDQPWVKKLVKAYQSPEVKEFITKQFKGSMVASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU1</accession>
    <name>Q63XU1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trmL</name>
        <name evidence="7" type="ordered locus">BPSL0449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522909.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107074.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0449"/>
    <dbReference type="EnsemblBacteria" id="CAH34437">
        <property type="protein sequence ID" value="CAH34437"/>
        <property type="gene ID" value="BPSL0449"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0449"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1208"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00185">
        <property type="entry name" value="tRNA_yibK_trmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="156" mass="17469" checksum="FD336B4EBB94EEB6" modified="2004-10-25" version="1">MFNVVLVEPEIPPNTGNVIRLCANTGARLHLIEPLGFPLDDAKMRRAGLDYHEYAQMRVHRDWDAFVAAEAPDPARMFAFTTRGSGRFHDRSFEPGDWFVFGAETRGLAPALVDRFAPEQRVRLPMRPGNRSLNLSNTVAVVVFEAWRQAGFEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XZ0</accession>
    <name>Q63XZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536451.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107025.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0399"/>
    <dbReference type="EnsemblBacteria" id="CAH34387">
        <property type="protein sequence ID" value="CAH34387"/>
        <property type="gene ID" value="BPSL0399"/>
    </dbReference>
    <dbReference type="GeneID" id="56527357"/>
    <dbReference type="KEGG" id="bps:BPSL0399"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1265"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYQLGMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="31315" checksum="0AC8E719869DF499" modified="2004-10-25" version="1">MMNAIKKLLPTHAAPPPDGARRPTPRRRLLHARLPPVGMLAVAAALAAGVAVTERIERPASGAPAVSRAQLDEWRAMVEQASEPNALGRLRALAQRGSADAQAALGLALAGSRDLALRDEGWRWLETAAHATPPENAPTSAGERDARLALGKAWLLGAGGAARDYPRALAMLRPLAAAGDPNAAYYVGLVYRSGYGTPADATEAARWFELAARQDIPAAQFMLANAYRDGSGVRRDEARALALYRQAADHELPEAVQALAIAYRNGELGLPRDADAFHAQWIEAAHALKHPALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y87</accession>
    <name>Q63Y87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cheavy metal binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106928.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0301"/>
    <dbReference type="EnsemblBacteria" id="CAH34290">
        <property type="protein sequence ID" value="CAH34290"/>
        <property type="gene ID" value="BPSL0301"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0301"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.328"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="82" mass="8479" checksum="C4CCCEC593CEA1BC" modified="2004-10-25" version="1">MGRSILQSIHIDWRGNMKLEVKDMSCGGCANAITQAIQTADSSARVSVDVASKVVDVGSALGIERVVAIIEAAGFHPAVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YI8</accession>
    <name>Q63YI8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198307.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106827.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0199"/>
    <dbReference type="EnsemblBacteria" id="CAH34186">
        <property type="protein sequence ID" value="CAH34186"/>
        <property type="gene ID" value="BPSL0199"/>
    </dbReference>
    <dbReference type="GeneID" id="56594455"/>
    <dbReference type="KEGG" id="bps:BPSL0199"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1520"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYPHHVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="267" mass="30750" checksum="273FCFED483DD7B7" modified="2004-10-25" version="1">MSARRQPRRPASPAASEQAPERPRRRRARPQAGGPVWLFDLDNTLHHASHAIFPAINRAMTQYIIDTLKVERAHADHLRTHYTRRYGAALLGLARHHPIDPHDFLKVVHTFADLPSMVRAERGLARLVAALPGRKIVLTNAPETYARAVLRELKIDRLFERVIAIEQMRDRRAWRAKPDATMLRRAMRAAHARLPDAILVEDTRGHLKRYKRLGIRTVWITGHLPGHLPSYGRPHYVDRRIGSLKSLRLGTRSGRRKCSRLTRMTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HU6</accession>
    <name>Q63HU6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529535.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112326.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2324"/>
    <dbReference type="EnsemblBacteria" id="CAH39810">
        <property type="protein sequence ID" value="CAH39810"/>
        <property type="gene ID" value="BPSS2324"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2324"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5959"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MREWNDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="368"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="475" mass="50596" checksum="26F0AF6AC32D497A" modified="2004-10-25" version="1">MHTFMLALRNLQRNRRRSITTLLAMVVGVCAVLLFGGFSKDITFGLQTDFVRRSGHLQIQRHGYYQYGSGNPVAYGIGGYARLIAQLRDDPVLAPMIAVITPTLQFGGIAGNFEAGVSRTVLAQGAIADEQDRMQQWNDYGFPLTPKPYPLVGTAPDAAIVGNGVARVLHLCAPLRVPDCGDGDVARQAAPQAASGASGADAPADVLALAAAEAHAQESGRGERAGAAHIEVLAANAYGAPNVGGFTVAKAEQQGVKELDDVYLAMHLPRAQRLVYGGDAPRVTAIEIQLRHTAQLPAARARLDRLFGGRFEGQPLDVLDFAALNPFYDQTNRMFSMIFGFVFVLIGAIVLFVVSNTMSTAILERTVEIGTLRSMGVRRGGIQALFVCEGALLGVVGASIGVLVALALAFVVNHSGLAWTPPARIDSVALTVRVWGEWRLIALTFVGLAFVAGFSAWLPARHAARLSIVDALRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I45</accession>
    <name>Q63I45_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112227.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39710">
        <property type="protein sequence ID" value="CAH39710"/>
        <property type="gene ID" value="BPSS2225"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2225"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6650"/>
    <dbReference type="eggNOG" id="ENOG5031D87">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LHFGFRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="118" mass="13217" checksum="67CA0CAA672B5F23" modified="2004-10-25" version="1">MAGAARDAPPPLEKAMTIRIEPGDKREIAETLGRYFEARSIPFHIEEHPADVLHIGFHADGHPAAVTVTFDEDAFAAFAQWDIEQKRLALRRLADEFAEMMAQRSPTAHAGDLHINRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IA4</accession>
    <name>Q63IA4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205736.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112168.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2167"/>
    <dbReference type="EnsemblBacteria" id="CAH39651">
        <property type="protein sequence ID" value="CAH39651"/>
        <property type="gene ID" value="BPSS2167"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2167"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5741"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="43139" checksum="3D5BB96381FF79D0" modified="2004-10-25" version="1">MTLIVVFLLSCLSLVIWLVLLFGRGGFWRARAARRLPPDARGAAAAAGWPAVAAVVPARNEADVIGEAVRSLVEQAYEGAFHLIVVDDHSTDGTAEAARAASAAVGCADRLTVLAAQPLPAGWSGKVWAQSQGIAAVRSLGLPADYLLLTDADIGHPPDAVAQLVTRAQAEQRDLVSLMVRLRCDSFWEKALIPAFVFFFAKLYPFSWINDPRNRTAGAAGGCMLVRRDALEEAGGIESIRGALIDDCSLAAQIKHRGAGRHPIRLDLADRSVSLRPYDSWRDIWNMIARTAFTQLRYSPVLLLGTLVGMTILYLVPPVAALAYGARAWPAWLAWASMCTAYAPMLSYYRRSPWWAPALPLVALFYVGATFASAVRYWRGKGGQWKARVQAPVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IB9</accession>
    <name>Q63IB9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112153.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2152"/>
    <dbReference type="EnsemblBacteria" id="CAH39636">
        <property type="protein sequence ID" value="CAH39636"/>
        <property type="gene ID" value="BPSS2152"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2152"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6558"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATECINR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="43835" checksum="8BE9C5AFA8CB1537" modified="2004-10-25" version="1">MMITTEAWVLYAGPEQTKKHEPVPGELRRETFQFADLEDDEALVEPLYGSWEANLDHALSRNPVDICRQRGEEKIVLGNGALVRVVDRGRGAKWPEIGEICMVMPFGKRDQYGFAELVYAYDAPGTIGVMARRTKIRADNLVPVPKGSRHSLLQWATYGRYFTAWDNWKVASKCWRAQLPDVDPADYLVFGWGGGTTLAELQLAKREGFRVAMTASGDKRLADIEKLGITPVDRRRFPHLAYDEARYRSDPDYQANYRASESAFAEIIGELSGGRGVAIFLDNLGGALYRATMRVVGRTGIVATVGWKTGMRLWNLRATECINRRLHIHTHAWRYDDSEAIRDFQESSDWVGPEPTEIYGFDDVPALASDYVTGKIKTYFPLYQVNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IH6</accession>
    <name>Q63IH6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPW_gp25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112096.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2097"/>
    <dbReference type="EnsemblBacteria" id="CAH39577">
        <property type="protein sequence ID" value="CAH39577"/>
        <property type="gene ID" value="BPSS2097"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2097"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6485"/>
    <dbReference type="eggNOG" id="COG3518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TIESEMW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017737">
        <property type="entry name" value="TssE1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03357">
        <property type="entry name" value="VI_zyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="178" mass="19380" checksum="97E18EAE9566113F" modified="2004-10-25" version="1">MRAAGGVRAAHDRLQPALLDRLTDAERERRTEPPDAQAIGGERLRAAVLRDLAWLLNTRNGEDGFVDWSAFAHAQASVLNYGMRPLVGKPMSGVERMSVEASIRDAIVRFEPRIAPDSVEVRSVLDAPGGAAGERRHNVLMFEIKGTLWSIPHPVEFVLRSDLDLETGAMALHPAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J22</accession>
    <name>Q63J22_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bo(3) ubiquinol oxidase subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome o ubiquinol oxidase subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Oxidase bo(3) subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquinol oxidase polypeptide IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquinol oxidase subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cyoD</name>
        <name evidence="16" type="ordered locus">BPSS1894</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooctamer of two A chains, two B chains, two C chains and two D chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase bacterial subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190895.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111900.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1894"/>
    <dbReference type="EnsemblBacteria" id="CAH39372">
        <property type="protein sequence ID" value="CAH39372"/>
        <property type="gene ID" value="BPSS1894"/>
    </dbReference>
    <dbReference type="GeneID" id="56598305"/>
    <dbReference type="KEGG" id="bps:BPSS1894"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5360"/>
    <dbReference type="eggNOG" id="COG3125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVVHMVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009486">
        <property type="term" value="F:cytochrome bo3 ubiquinol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014210">
        <property type="entry name" value="Cyt_o_ubiqinol_oxidase_su4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02847">
        <property type="entry name" value="CyoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH39372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="110" mass="11720" checksum="EC55D718CCD6B66B" modified="2004-10-25" version="1">MADMHLSHDGEAHGTVGGYLAGFILSVLLTAASFGLVLSGALSSHASLIALAVLAFVQIVVHLVYFLHMNGSSSQRWNVMAFSYTVLTAAILIVGTLWVMHNVGMNMMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J56</accession>
    <name>Q63J56_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSS1862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525057.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111866.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1862"/>
    <dbReference type="EnsemblBacteria" id="CAH39338">
        <property type="protein sequence ID" value="CAH39338"/>
        <property type="gene ID" value="BPSS1862"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1862"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5318"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LANAWDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="356"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="614"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="391"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH39338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="669" mass="72671" checksum="74B7C4C803C5A2DA" modified="2004-10-25" version="1">MVQKTTHPGGRAFTDVLAFTFRHWRAQPVRIAGIAALALATALGDVLTPLFAGRLVDALSHGVAAADKAAAWSRALHAFGVLIGIGLACTLLRQAVFRNIIVLTLKMMSEIAANAFHRVQRFSTDWHANSFAGSTVRKITRGMWAIDLLNDTLLVALLPSIVMLTGATLLLGLHWPVMGAVVGGGSVVFIAVTVAMSLRYVAPAARLGNLWDTRMGGALADAVSCNPVVKAFGAETREETRLDGVVSKWRARTRRAWRRGTLNGGVQGAMLAAMQAAILGAALWLWAHDRASIGDITFALTTFLVLQGYLRDIGMHIRNLQRSVNDMEELVSLERQPLGIDDKPGAKPISIARGEIRFEHVTFGYSGAHAKPLYENFSIRIAPGERVGLVGHSGSGKTSFIKLIQRLYDVDGGRITIDGQDIAEVTQASLRSQIAIVQQEPLLFHRTLAENIAYARPGATRDEIERAARLASAHAFIDALPQGYDTLVGERGIKLSGGERQRVAIARAFLADAPVLILDEATSSLDSESEVLIQQAMERLMVGRTTLVVAHRLSTVRALDRLIVLDKGRVIEEGSHDALIRLEGGVYRRLFERQALELAKGLIEQTGGTVADWLRDEQDEHGGRDERNERGERDKPGALDGHDARRTHGVLDESRDGGQADNSAMAMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JE8</accession>
    <name>Q63JE8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111774.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1768"/>
    <dbReference type="EnsemblBacteria" id="CAH39243">
        <property type="protein sequence ID" value="CAH39243"/>
        <property type="gene ID" value="BPSS1768"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1768"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5200"/>
    <dbReference type="eggNOG" id="COG4655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LSVMDYN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018705">
        <property type="entry name" value="DUF2134_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09977">
        <property type="entry name" value="Tad_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Tad_C" evidence="3">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="597" mass="60548" checksum="848136191A5D0669" modified="2004-10-25" version="1">MNEPTRQTTGDLSERRGPNRRRRAPRSPARQRGSLAIIAAIAIGVVIAALGAVDLGNLFYQRRALQSIADLAALAAAQTMDDGCAKPAATAQSAALGNGFDSTVSGQSMTVVCGRWDVKDNVGPSFFAGSASGAAAGSDAQLNAVQVTVTRAVPYYFLGAQRTIAATSTAEATNVGAYSIGTTLAQLQGGVVNALLNGLLGANLNLSVLSYQGLANARIRIKDLMAAANVGTVSALLSTQTTVPQLANWMLSALSQTSVANADLQTSIGALQTIVSANIPGGRTFTIGNTANSAGIFSIGLSNPQAALDATFSPFDALLVAAEIATGQTAFSLANGLNIGGLNANLQVQIIQPPVLGIGEAGIDPVTKTWRTIARTAQVRLYLNIGLGTANLPLGLLGALLPVQVNLPLSLQIAPGQAWLQSASCTASPSTCASAIGVQTGLTNLCIGDTPANMSASLPFTCSTPATLVNVANLVTIKSLVSFPADVPASQTPTLTFYGTTGGYQSTNSNGVGSVLGNALSGLGASLQQTQISLFGISLPLGPIQTALNAFLGGVLPPLLSGLDAAIVPLLQLLGVQVGESTIHDMSLTCGVSQLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JJ3</accession>
    <name>Q63JJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188261.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111729.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1723"/>
    <dbReference type="EnsemblBacteria" id="CAH39197">
        <property type="protein sequence ID" value="CAH39197"/>
        <property type="gene ID" value="BPSS1723"/>
    </dbReference>
    <dbReference type="GeneID" id="56598080"/>
    <dbReference type="KEGG" id="bps:BPSS1723"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5140"/>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VCDHYAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040186">
        <property type="entry name" value="Citramalyl-CoA_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105">
        <property type="entry name" value="PTHR11105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="2">
        <location>
            <begin position="49"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="36569" checksum="6C85C2B1D91CDEBF" modified="2004-10-25" version="1">MSALTPAEVLYEGVAPPAILPCCDHYAGSEKLMLKSLALQAELGPVFDITLDCEDGAAVGREAEHAARVAALVGGEANRFGRVGVRIHDISHPHWRDDVRVVLRAARPPAYLTLPKVGGAADAAEMCAFIEASRVELGIAQPIPVDVLIETHGALADAARIAALPIVATLSFGLMDFVSAHHGAIPDDAMRAPGQFDHPLVRRAKLEIAAACHAHGKTPSHNVTTEVRDMRVVANDARRAREEFGYTRMWSIHPAQIREIVAAFAPRADDIARASRILLAAQAADWGPTRHDDALHDRASYRYYWAVLRRARATGQPLPAESAPLFGDAGERAARGREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JK2</accession>
    <name>Q63JK2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533348.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111720.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1714"/>
    <dbReference type="EnsemblBacteria" id="CAH39188">
        <property type="protein sequence ID" value="CAH39188"/>
        <property type="gene ID" value="BPSS1714"/>
    </dbReference>
    <dbReference type="GeneID" id="56529875"/>
    <dbReference type="KEGG" id="bps:BPSS1714"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5131"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHTWASN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="324" mass="35876" checksum="E36D7F7D37E06656" modified="2004-10-25" version="1">MKPRYERVAIPDGCSVRVYRRRLAQIPFEWHHHPEYELTLTLNSLGKRFVGDHVADYAGDDLVLVPPNLPHTWVSDERLDPGEPLVALVLWFDGDWAQRVADCCPEFAGLRTLLRRAAPGLAFAPAAAADMRARLPALVDRAPRVRLAAALDVLACLADAPATPLATAAAYRAASGAALAPEAERLDRVLDLLDRRFHEPLRVAELAALAHLSERSLQRRFARHVGESIGSYLQRLRLAHAARLLASTDWPVSLVATRSGYANLANFNRQFLAARRVTPRAYRRFLAEHGRAPDDMPAHEASIDVRPPSLDHGPPRAGKNKIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JM4</accession>
    <name>Q63JM4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative bacteriocin production related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188369.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111698.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1693"/>
    <dbReference type="EnsemblBacteria" id="CAH39166">
        <property type="protein sequence ID" value="CAH39166"/>
        <property type="gene ID" value="BPSS1693"/>
    </dbReference>
    <dbReference type="GeneID" id="56598048"/>
    <dbReference type="KEGG" id="bps:BPSS1693"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5105"/>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FTWVDWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="17438" checksum="AA252B2BE3AACA12" modified="2004-10-25" version="1">MLTAFDYAVLLVIGLSALRGAWRGFVGEIFGLIGWIAAFLIACRFVGVVLPYIPATWPGGALTQWVIAFALIIIGVVLVAGVANALLSRIAQATGLGGVDRSLGMMFGLVRGVLLVLLLVAAAGLTELPKQEFWRDALLRPFAEQGVRELKPLLPDGLAAYIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JM6</accession>
    <name>Q63JM6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">O-succinylhomoserine sulfhydrylase</fullName>
            <shortName evidence="2">OSH sulfhydrylase</shortName>
            <shortName evidence="2">OSHS sulfhydrylase</shortName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">metZ</name>
        <name evidence="5" type="ordered locus">BPSS1691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:27826"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family. MetZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940940.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111696.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1691"/>
    <dbReference type="EnsemblBacteria" id="CAH39164">
        <property type="protein sequence ID" value="CAH39164"/>
        <property type="gene ID" value="BPSS1691"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1691"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5993"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THGGIIV"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071268">
        <property type="term" value="P:homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02056">
        <property type="entry name" value="MetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006234">
        <property type="entry name" value="O-succ-hSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01325">
        <property type="entry name" value="O_suc_HS_sulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="405" mass="43973" checksum="009D5DB53EE46F2B" modified="2004-10-25" version="1">MRLKTDERNMDDSLNFDTLAVRSGTLRSEFNEHSEALFLTSSFCYASAAEAAERFKHSEDYYTYSRFTNPTVTMFQDRLAALEGGEACIATASGMAAITSVVMAALQAGDHLVSSRSLFGSTLGLFGQIFAKFGIETTFVDPADLDAWRAAVRPETKMFFLETPSNPMTELADIEAVGRIAKAAHALFVVDNCFCSPVLQQPLKLGADVVMHSATKFLDGQGRVLGGALVGSKAFIMEKVFPFVRTAGPTLSAFNAWVLLKGMETLSLRVNRQSENALEIARWLEAHPAVKRVFYPGLESHPQHALAKRQQKSGGSVVSFELNGDTPERQRANAWRVIDGTKIVSITANLGDTRTTITHPATTTHSRIAPEAREAAGITEGLIRLAVGLEDPADIRDDLARGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT1</accession>
    <name>Q63JT1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205655.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111641.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1633"/>
    <dbReference type="EnsemblBacteria" id="CAH39108">
        <property type="protein sequence ID" value="CAH39108"/>
        <property type="gene ID" value="BPSS1633"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1633"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5020"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRQHWNQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041464">
        <property type="entry name" value="TubC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18563">
        <property type="entry name" value="TubC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2181"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3300"/>
            <end position="3375"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4362"/>
            <end position="4436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2078"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3200"/>
            <end position="3226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="4343"/>
            <end position="4362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2085"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3201"/>
            <end position="3226"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1110"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2216"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3335"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="4440" mass="487747" checksum="9CA96AF94913B2C3" modified="2004-10-25" version="1">[encoded data, 4440 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K02</accession>
    <name>Q63K02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188527.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111570.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1564"/>
    <dbReference type="EnsemblBacteria" id="CAH39037">
        <property type="protein sequence ID" value="CAH39037"/>
        <property type="gene ID" value="BPSS1564"/>
    </dbReference>
    <dbReference type="GeneID" id="56597911"/>
    <dbReference type="KEGG" id="bps:BPSS1564"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4929"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VSMRQED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17129" checksum="E8D5D8B425FE40A0" modified="2004-10-25" version="1">MIELDKTDRAILAAVQLDGRIPVARLADSVGLSETPCARRLKRLESDGYIERYRAQLSRNALGFGVVAFVLLRCSVHDRSVANRFEREVLGIPRILSCHNVSGSADYLLQVVAHDLDDYGTFLRETLRVLPGVTSIESALSLREVKREAELPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K61</accession>
    <name>Q63K61_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205630.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111511.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K61"/>
    <dbReference type="STRING" id="272560.BPSS1504"/>
    <dbReference type="EnsemblBacteria" id="CAH38977">
        <property type="protein sequence ID" value="CAH38977"/>
        <property type="gene ID" value="BPSS1504"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1504"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4851"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRGANLM"/>
    <dbReference type="PHI-base" id="PHI:3420"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="2">
        <location>
            <begin position="122"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="880" mass="91344" checksum="9C4E3FBE68BA553E" modified="2004-10-25" version="1">MKIVKPETLALMCRTLRIERADRLSIGALACFALRAHAPDGPGDLAPEATLWQIAQQWLGAHAPLDEGWPKPAGEFLVYGDACAPAGREHAGGAPFAVRARIGAACKARLVDARDPADRVLADFRALPPSHPQRVRDLGPFDARWLAERWPHLPSGTRAEHFHTAPRDQRIAGFWRGDEDIELVNLHAQHPIVAGALPRVRARCFVERSAGGATRVDACPMRAETVWLFPGAACGIVLYRGLATIDDEDGDDVLRVIAGWEDAAAPPLPADAYLGRPASGGAGSRPTPAPDAAPVASVVPAALTAEEAHADEHAPGGSASASQAHSPAAPEFPEAPHAPDLSALEREAAALAGQTDALLAGLGITEADIARLLPARDAPAELNLDQLATLAAELDAQTAQWQAQQAAAAVERGDAASATPAAPATPDAEAAHEASLADLLRQADAQMRALVEQHGLSRARMEAAARTLPELAPLAGSLDALDALDAPLDVDALTAGLAAAGGDAAAEPDTPAEPSPPAPANEFAAAVPAPASSTAAPPVDDAPPGPLTREQVIERHARGLGFAGLDLSGLDLSSAALERADFRRARLERTRFAGCRLAGASFERALLSHADFSNADLRDAVFAGASAPGASWRGAVLERARLEHGDFSGGDFAQASLADSHCAHAQFDASAMTALVAARIDGTHASFAGCTLDAADFTSARLPRANFQHATLADAALACAHCDGAEWYGAQAPRARLRAASLRGSRADASTSFRQADLSSAALDDANWDGVDLRGTNLHEATLDGASLARANASGAQLTRARARRADLTQADLTHADARCSNLHGASLRRARLGGTQLQSSNLYGADCYGTALARPQLDGANIERTLLAVPGRPELAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K92</accession>
    <name>Q63K92_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528767.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111480.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1473"/>
    <dbReference type="EnsemblBacteria" id="CAH38945">
        <property type="protein sequence ID" value="CAH38945"/>
        <property type="gene ID" value="BPSS1473"/>
    </dbReference>
    <dbReference type="GeneID" id="56530113"/>
    <dbReference type="KEGG" id="bps:BPSS1473"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4810"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRWVHFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="601" mass="64705" checksum="6E16580441930BAE" modified="2004-10-25" version="1">MSVSVRSYLSPTLVLLAFDWPDAQRRDDFLGFAIKRTPGFWSADGKTRAATSWLPNRLTFDGPAAHTQGDAPTDQAPIQKFMWWDARIDPPDRGRSFRYDVYPVVGTPASLQVLEAEAGVCAITLPAHVEDGVGTWFNRAVVSSQAFAKQVRALHLADGGAPSPDAALRLRTWLANDLQETFGLMLGADARRAVSAVYHLTDPLWAIPAFDAFGRAHGANALAIVYDAHETKRGSGEPPLPSPNQPAVERLTGVATLAPRDKTRIMHDKFIVAGDETGPARVLTGSANFTAEGIAEQANVLHTFESAALAELYNARARALASNPGIAETARLAPGWSEPVEIGSARVRVSFSPEPRGVRTQIDTIVEAVRGAQHSVAFCLFMPTDAALRDACFAAGERGLMMFGLVNAISARGAQQADADRRDGKTLDAARLANLELYHRSRSNRDVIDAAYFSPATVPDGFETELRLFPGEPAPPYPPVVVHHKFVVIDAEGANPIVYSGSANMSANSEHYNDENLLEIRDARIAGIYLAEFLRLYEHYRARALAIASRRGDGGGSTAGNAGAHGGLALQPDSRWAKKYFVAGSPEEKARIALAAPVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KF4</accession>
    <name>Q63KF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111418.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1406"/>
    <dbReference type="EnsemblBacteria" id="CAH38881">
        <property type="protein sequence ID" value="CAH38881"/>
        <property type="gene ID" value="BPSS1406"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1406"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5639"/>
    <dbReference type="OMA" id="AWHESIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="34646" checksum="8DDAC7BA5DD2305D" modified="2004-10-25" version="1">MPARKSSEEACVNRSFRSSNHLSSPAQLQQSADAQQRTADRQAARNSALTAALYRGTTNFTYSKDPAPRGRLPSVSKTNALARKRKITSRLRRNAAGNGDGDGDDVDGALVPHFEAEPGGDRDRDGRGGREQPRDDPMDIETCRRLPRMQAAESRAAAAPRGRFDAVADLHAAPGQEGERADAIARAWESEMFGLQVFPPNAPRTAEILELSLDFLLIQRRIGPIPVSTLARLRESPAPTPVACGRDRLPGETAPDDRRRFNLLFPLLWLQAGMPRTAVRLDCAIAKLLAIRNALPDNPLATDDAQAEPTPAPHASSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KG6</accession>
    <name>Q63KG6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Type 3 secretion system ATPase</fullName>
            <ecNumber evidence="13">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">sctN</name>
        <name evidence="16" type="ordered locus">BPSS1394</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="13"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205607.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111406.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1394"/>
    <dbReference type="EnsemblBacteria" id="CAH38869">
        <property type="protein sequence ID" value="CAH38869"/>
        <property type="gene ID" value="BPSS1394"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1394"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4718"/>
    <dbReference type="eggNOG" id="COG1157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKQVEML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013380">
        <property type="entry name" value="ATPase_T3SS_SCTN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02546">
        <property type="entry name" value="III_secr_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AAA" evidence="15">
        <location>
            <begin position="169"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH38869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="449" mass="47950" checksum="75947314B576BC7B" modified="2004-10-25" version="1">MSADEPLRTAEFSHLADAIEREILAVSGVVRTGRVLEVIGTLIKVSGLDVALGELCELRTREGRLLQRAEVVGFTRDVALLSPFSQLEQISRTTQVIGLGRPLSIPVGDALLGRVIDGLGEPLDGGPPLASETLQPLIAAPPEPMSRRMIDAAMPTGVRVVDAMMALGEGQRMGIFAPAGVGKSTLLGMFARGAACDVNVIALIGERGREVREFIELILGQAGMARSVVVCATSDRSSMERAKAAYAATAIAEYFRDRGRRVLLMMDSLTRFARAGREIGLAAGEPPARRGFPPSVFAELPRLLERAGMGRTGSITALYTVLAEDESGSDPVAEEVRGILDGHMILSREVAAKNQYPAIDVLGSLSRVMPLVVDDGHMRAAARVRELLAKHREVEVLLQIGEYKAGANPLADEAIAKADAIRSFFSQRTDDYAAAEDTVARLYALSGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KR0</accession>
    <name>Q63KR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family M55 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204467.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111311.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1302"/>
    <dbReference type="EnsemblBacteria" id="CAH38772">
        <property type="protein sequence ID" value="CAH38772"/>
        <property type="gene ID" value="BPSS1302"/>
    </dbReference>
    <dbReference type="GeneID" id="56597504"/>
    <dbReference type="KEGG" id="bps:BPSS1302"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4591"/>
    <dbReference type="eggNOG" id="COG2362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATGVTWP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="29070" checksum="A29F7E01C375A58F" modified="2004-10-25" version="1">MKVLISTDIEGVAGVVSVEQTRAGNPEYERARRWMTAEANAAVEGAFAGGATRVWVNDSHGGFRNLLPDGIDARARVVLGKPRPLGMMAGLEAGPDLVFMIGYHAKAQTRGLLAHTINSSAFARVVLDGRDVGEAGLYGALAHEYGAHVALLSGDDVFVDETRPLFPAAQFVTVKEAAGFASGASMTPAAACGAIGVAARQAVEQAREGARAARPHAPRAARCELQAQSVAAADLFCQWPSLERVDALTLRFFAPSIEHVVRTLNCLSAMSFMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KX0</accession>
    <name>Q63KX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="18">1.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">nirB</name>
        <name evidence="18" type="ordered locus">BPSS1243</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="18"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111251.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1243"/>
    <dbReference type="EnsemblBacteria" id="CAH38710">
        <property type="protein sequence ID" value="CAH38710"/>
        <property type="gene ID" value="BPSS1243"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1243"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5424"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVIGHGM"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="12"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="17">
        <location>
            <begin position="329"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="433"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="14">
        <location>
            <begin position="569"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="13">
        <location>
            <begin position="641"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAH38710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="861" mass="92666" checksum="33E45D02D2A0DD9A" modified="2004-10-25" version="1">MSTGKQRASIMKIVVIGHGMVGHKLLECIAAGAPGALAAPRVAVVCEEPRPAYDRVHLSEFFAGKSADDLSLVEPGFFERHPNFRLLLNTKAVAIDRAARTVALSTGETLAYDKLVLATGSTPFVPNVPGRERAGCFVYRTIEDLEAMRACGARANSGVVVGGGLLGLECAKALRDMGLAAHVVEFAPRLMAVQVDEGGGRMLREKIEALGVQVHTGKNTLEIVDGETGAHRMAFADGTHLDADMIVFSAGIRPRDEIARACGLEIGPRGGVAIDERCRTSDEDIYAIGECAAWNGQTFGLVAPGYDMARVVARQLAGGEGAFAGADLSTKLKLMGVDVASIGDAHGRTPGSRAYQFADERRGVYKKLVVSECGKALLGAVMVGDAADYGTLLQMMLNRIELPRSPEFLILPQADGAAKPALGVDALPDAAQICSCNNVTKAQLREAVAGGATSLGALKGCTGAGTSCGGCVPLVTQVLKAEMKKQGLAVNNHLCEHFPYSRQELYHMVRVERFKTFGALLKKHGRGLGCDVCKPAVAGILASCWNEFVLKKEHAALQDSNDYYLANIQRDGTYSVVPRMPGGEVTPEGLIAVGEVARKYGLYTKITGGQRVDLFGARVEQLPLIWEELIAAGFESGHAYGKSVRTVKSCVGSTWCRYGVGDSVGLAIELENRYKGLRAPHKLKFGVSGCTRECAEAQGKDIGVIATEKGWNLYVCGNGGMKPRHAELLAADLDRATLVRYVDRFLMFYIRTADRLQRTSVWRDNLEGGLDYLIDVVVHDKLGLAAELEAEMQHVVDTYECEWKRAVTDPATRRRFRHFVNSDAPDSTIAFVEARGQIRPVTPDERDAEGQADRQPETETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KZ9</accession>
    <name>Q63KZ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524157.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111222.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1214"/>
    <dbReference type="DNASU" id="3097260"/>
    <dbReference type="EnsemblBacteria" id="CAH38681">
        <property type="protein sequence ID" value="CAH38681"/>
        <property type="gene ID" value="BPSS1214"/>
    </dbReference>
    <dbReference type="GeneID" id="56530373"/>
    <dbReference type="KEGG" id="bps:BPSS1214"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4453"/>
    <dbReference type="eggNOG" id="ENOG50345AQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="231" mass="26233" checksum="A7477CB01A76B6CD" modified="2004-10-25" version="1">MKSDSAIFSFIENFPTSASLKTADTGKYIANNIHNSIQFGIKNPKDLEGLTIQDVKFNQKDWGIRYAQLIQDLDRSARENKSHVMGRHQFLDDCGEAQVEEMIKFPILGSRGNILGIVTYRNDITRTLPPIEIYRLNRGFYGASESINRVLIYFGIEKYFFAPLTDAQIQVFLLKSERLTNKEISRLLGISDRTVECHCAALRSKIIDGNLPYILSLVKGSFSCDQNLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L22</accession>
    <name>Q63L22_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111199.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="DNASU" id="3095129"/>
    <dbReference type="EnsemblBacteria" id="CAH38655">
        <property type="protein sequence ID" value="CAH38655"/>
        <property type="gene ID" value="BPSS1187"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1187"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5352"/>
    <dbReference type="eggNOG" id="ENOG502ZB6C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYSAPSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="29035" checksum="35DF9BB9057393E9" modified="2004-10-25" version="1">MQPSATDSTISAGTQPHIVYSERASAPGPLLVFIPGTGGKTPKTAETEQAFIGTALAHGYRVIILSYIDTPAIAQVCTKRVLANDPACAEQVRQKRAFGDDTTARIDDAPQDAIVHRLNALIRYLAAHNAGDHWEQYLAGERLNWRAIVLSGQSQGGGMAAYIAKRIAIRGVIDFSGGWDMRSDSDIASWYSAPSATPPERWYGTYHADERFASAIAASYRAMNIPVSHQFSLSEPVRHPEGKNPGHGEGASNPVYRGIWETMLTGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L76</accession>
    <name>Q63L76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111145.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1132"/>
    <dbReference type="EnsemblBacteria" id="CAH38600">
        <property type="protein sequence ID" value="CAH38600"/>
        <property type="gene ID" value="BPSS1132"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1132"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4351"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKPYPGK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="139" mass="15116" checksum="C9628651531BC2DA" modified="2004-10-25" version="1">MHPCVRQSLERWHAMVAARDMSTLADIADPNAVFRSPIAHSAYAGAAALTLAIGTVVNVFEEFTYHRQMATDDGLSVVLEFSARVGDKRLKGIDLIRFDEAGKIVEFEVMVRPASGLQALGAEMGARIGARLPEFKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LG3</accession>
    <name>Q63LG3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS1048c</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009971783.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111058.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1048c"/>
    <dbReference type="EnsemblBacteria" id="CAH38513">
        <property type="protein sequence ID" value="CAH38513"/>
        <property type="gene ID" value="BPSS1048c"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1048c"/>
    <dbReference type="eggNOG" id="ENOG5030XH1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="71" mass="7862" checksum="671838575EEF613B" modified="2004-10-25" version="1">MEQSNERGVAERREALFEDLAELGIGAGVCVPAFVVYTPPRTARGDRAAANAMKELRPLLAKLARRRLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LH2</accession>
    <name>Q63LH2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cobalt-zinc-cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">czcC</name>
        <name evidence="3" type="ordered locus">BPSS1043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111049.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1043"/>
    <dbReference type="EnsemblBacteria" id="CAH38504">
        <property type="protein sequence ID" value="CAH38504"/>
        <property type="gene ID" value="BPSS1043"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1043"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5176"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVERIYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="452" mass="46511" checksum="DC8B5077781EF3F7" modified="2004-10-25" version="1">MSAAIAASAVQAQAQPAPAPSAPDGPAATPPDARAASVSVTPAVSPAPISTSTVSVAPPALSLDDALALAAANNPLLKSARSSADASVGALVQAGARPNPTVSFLQEGFGRQERTTTAVVSQPIELGGKRRSRVDAASYGRESALASLDGRAAALRADVTGAFYGVLAAQRQLQVADESAAIAARSADMADKRARAGKVSPVEATKARVAQTAAQIELSNAQTRVAAALARLANATGSADVRGRAASGDLDALPAAEPLPQLLGRLDDAPLARAAKADMLRTNAQIAIERAKRVPDITVSAGVKHVVTGGAPDNQAVVGISIPLPLFDTNRGALLEAVHNAAKASADFDAERARLRLDLTQAYANYERATGEARRLKADVLPAARQSLDAMSRGYQLGKFGFLDVLDAQRTLFDAQSRYVQALADAHQSYADIERVVGAPARDASRPLAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LL8</accession>
    <name>Q63LL8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531777.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111003.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0997"/>
    <dbReference type="EnsemblBacteria" id="CAH38458">
        <property type="protein sequence ID" value="CAH38458"/>
        <property type="gene ID" value="BPSS0997"/>
    </dbReference>
    <dbReference type="GeneID" id="56530548"/>
    <dbReference type="KEGG" id="bps:BPSS0997"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7321"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMEMSPT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="559" mass="62757" checksum="1ED9D40099A1A6CB" modified="2004-10-25" version="1">MGDYLAQDARIERITVRDPEARTWFDRGLLWAYGFNFEAAVDCFQEAARIDPDCVLAYWGIAYASGCNYNKQWKVFHPRMIARCMKLARDAIRRAQACRAGASALEMALVRAIECRFQAEGAHDEALLRRWNDDYARAMRDVYLSCPDNLDVAALFADALINRTPWKLWDMSSGKTADGADTDEAIAVLERALAQVDANGLAPHPGLLHVYIHTIEMSPTPEKALRAADALRDLAPDVGHLLHMASHIDILCGHYHDAIVANDRAIAANQRVLDRHPQWLEFRLYCVHDIHFKIYAAMMLGRFSAAWQGVLELEALITEALLRVEQPPMAYLLEGFLSVRVHVLIRFGKWREILEQPFPANAALYCNTTAMLHYARGIAYANLKLAGPAAQARRAFSIAQAALHEHRYVTNNTCADLLKIAACVLDGEIAYHEDRFDEAFAHLRRAVELDDGLEYMEPWGWMMPTRHPLGALLLAQGHVEEAERVYRADLGLDSTIYRSLQHPGNVWSLQGYVSCLRRLGKHETADALQPALDVARARADVEIGVSCFCAAPSKRGCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LQ8</accession>
    <name>Q63LQ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ddpX</name>
        <name evidence="5" type="ordered locus">BPSS0955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939993.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110963.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0955"/>
    <dbReference type="EnsemblBacteria" id="CAH38417">
        <property type="protein sequence ID" value="CAH38417"/>
        <property type="gene ID" value="BPSS0955"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0955"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7266"/>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRTEWWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="189" mass="20970" checksum="AAF1D5B0CBCD5247" modified="2004-10-25" version="1">MKTSAHRLVEIAPHTHGVDVDLVYATERNLTGQPIYRRAHCLLLEPAEAALRRAVAVAARSGLRLRIYDAYRPPRAQQILWDFLPDPNFVADLGRGSNHSRGTALDLTLVDANGDALDMGTGFDKMIAASNHFHDGLPEPVQRNRLLLLGVMHAAGFTHIASEWWHYELPGSRALPLIDEEAGGPWRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LU8</accession>
    <name>Q63LU8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195424.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110923.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38376">
        <property type="protein sequence ID" value="CAH38376"/>
        <property type="gene ID" value="BPSS0914"/>
    </dbReference>
    <dbReference type="GeneID" id="56597274"/>
    <dbReference type="KEGG" id="bps:BPSS0914"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7211"/>
    <dbReference type="OMA" id="ANEISPH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="74" mass="8115" checksum="14F8BC275286FD73" modified="2004-10-25" version="1">MDTSTVDAVAIAAKLAKEISPHPPQWIIDLYAATLVQRHGFARTGDEIKQAQKAFFESRQAIVAALSTYRSPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M83</accession>
    <name>Q63M83_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528054.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110788.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0779"/>
    <dbReference type="EnsemblBacteria" id="CAH38239">
        <property type="protein sequence ID" value="CAH38239"/>
        <property type="gene ID" value="BPSS0779"/>
    </dbReference>
    <dbReference type="GeneID" id="56530769"/>
    <dbReference type="KEGG" id="bps:BPSS0779"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7031"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAKRQTD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="30936" checksum="4C4594658241F87B" modified="2004-10-25" version="1">MSYEGRWKTVEVIVDGAIAWVTLNRPDKRNAMSPTLNAEMIDVLEAIELDPEARVLVLTGEGEAWTAGMDLKEYFREVDAGPEILQEKIRRDASRWQWQLLRMYAKPTIAMVNGWCFGGGFSPLVACDLAIAADEAVFGLSEINWGIPPGNLVSKAMADTVGHRQALYYIMTGETFTGAQAAQMGLVNRSVPRAQLRDAVRALAAKLLDKNPVVLRNAKHGFKRCRELTWEQNEDYLYAKLDQAQLRDPEHGREQGLKQFLDDKTIKPGLQAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MC1</accession>
    <name>Q63MC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS0738A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110750.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38198">
        <property type="protein sequence ID" value="CAH38198"/>
        <property type="gene ID" value="BPSS0738A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0738A"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4802"/>
    <dbReference type="OMA" id="ARIMRIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="120" mass="12826" checksum="E57CF98147CFB8B1" modified="2004-10-25" version="1">MRREPNRRLPGASPLDRFAAAARGGEPVSAAHCTAASHARVAAKTVHPWKCGRAKPWARSVQDAGYRDGHTRLCASNRPFAESCSTCRRQAGAAGVAHETGRAGCERRGPIATRTSARHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MI4</accession>
    <name>Q63MI4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase subunit III protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110687.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0673"/>
    <dbReference type="EnsemblBacteria" id="CAH38132">
        <property type="protein sequence ID" value="CAH38132"/>
        <property type="gene ID" value="BPSS0673"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0673"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4719"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SESLMFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="197" mass="21325" checksum="D61455766F51F30A" modified="2004-10-25" version="1">MSRIASRIAAASAAPARVPGEAELWIFILGDMLVFAVFFTILSAHHVLHPALFDAGRRQLNLAFGLVNTLALLTSSAFVALGLGEAKAARLAAAKRRFVVAAALGALFVAIKCAEYAQKIAAGANPLVNDFYMYYFVFTGVHLLHVAVGLIALALMIRRCVRPAAEPRDVGFLEGAAVYWHMVDVLWVVLFLLIYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MP0</accession>
    <name>Q63MP0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoenolpyruvate mutase</fullName>
            <ecNumber evidence="2">5.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523200.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110631.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0610"/>
    <dbReference type="EnsemblBacteria" id="CAH38067">
        <property type="protein sequence ID" value="CAH38067"/>
        <property type="gene ID" value="BPSS0610"/>
    </dbReference>
    <dbReference type="GeneID" id="56530939"/>
    <dbReference type="KEGG" id="bps:BPSS0610"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6792"/>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IIHGDDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050188">
        <property type="term" value="F:phosphoenolpyruvate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012698">
        <property type="entry name" value="PEnolPyrv_PMutase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02320">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="303" mass="33443" checksum="EDD3DDDA3E3098AD" modified="2004-10-25" version="1">MPIRELISAPITNEQRRRSFKEKLATGRALRFIESHSPISAMISEKVYVAHGASQSEFDGFWSSSLTDSTLRGRPDIEILDIASRLANVQHIFDVTTKPLIIDGDTGGKPEHFALNVQSLERSGVSAVIIEDKTGLKKNSLLGNDVIQHQESIEDFCEKIRVGKAAQITDDFQIIARVESLILDKGMPDALARAAAYCEAGADGVMIHSRKKDADEVIEFAQRFRACRRDAYLVCVPTSFNAISFSELARHFSVVIYANHLLRAAYPAMLAVAEGILAHGRTLEIEERCLPVNEILKLIPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS3</accession>
    <name>Q63MS3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">braC</name>
        <name evidence="5" type="ordered locus">BPSS0575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523159.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110596.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63MS3"/>
    <dbReference type="STRING" id="272560.BPSS0575"/>
    <dbReference type="EnsemblBacteria" id="CAH38032">
        <property type="protein sequence ID" value="CAH38032"/>
        <property type="gene ID" value="BPSS0575"/>
    </dbReference>
    <dbReference type="GeneID" id="56530974"/>
    <dbReference type="KEGG" id="bps:BPSS0575"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6747"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MEFTGAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266452" evidence="3">
        <location>
            <begin position="25"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="39003" checksum="F17A55ABFD73EFAC" modified="2004-10-25" version="1">MMLSRLTSMSLAAMLVAAGAAAHAETVKIAIAGPMSGSVAQYGDMVKAGALTAVEQVNAAGGAGGNKLEVVMMDDACEPKQAVAVANKIVSQKIKFVIGHVCSGSTIPASDIYENEGVVMITPSATAPQLTEGKKRKFIFRTIGRDDQQGPAAAQYIINKVKPKKVAVLHDKQSYGQGIASAVKKELDAAKVPVVIFEGINAGDTDYSAIVTKLKSQGVDFVYFGGYHPEMGLLMRQAREQGVKAVFMGPEGVGNKDVTAIAGPASEGMLVTLPADFTIDPANAGVMKAFAQKKRDPNGTFQMPAYSGVKIIADSIAGAKSTDPAKVAAYMHQHTFDTPIGKVAYDAQGDLKSFKFVVYKWHKDATKTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MU2</accession>
    <name>Q63MU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186918.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110577.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0556"/>
    <dbReference type="EnsemblBacteria" id="CAH38013">
        <property type="protein sequence ID" value="CAH38013"/>
        <property type="gene ID" value="BPSS0556"/>
    </dbReference>
    <dbReference type="GeneID" id="56530994"/>
    <dbReference type="KEGG" id="bps:BPSS0556"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6724"/>
    <dbReference type="eggNOG" id="COG2113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MWQGVAT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266996" evidence="2">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="287" mass="30851" checksum="EF3DFA0B95DC82AB" modified="2004-10-25" version="1">MKFLTKLIGCGVLAMMLAAVAPTQADTKPTLKIGYVEGWDDSVATSNVAARIIETKLGYPVQLVPVAAGVMWQGVARGDLDATLSAWLPVTQGAYWEQFKTKVVNLGTNFPDAKIGLIVPAYVKAKTIADLNAQKNDFAGRIVGIDAGAGVMRKTDDAIKAYGLNYSLMPSSGSAMTAELARSIHSNKAVVVTGWAPHWMFAKWKLRFLDDPKKVYGEAEHVDNVVNPALETKAQPVVAFLKKFQWKPGEIDGVMLAIQNGSKPAAAADAWIAAHGDRVGEWLGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MW7</accession>
    <name>Q63MW7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA-family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525553.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110552.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0531"/>
    <dbReference type="EnsemblBacteria" id="CAH37988">
        <property type="protein sequence ID" value="CAH37988"/>
        <property type="gene ID" value="BPSS0531"/>
    </dbReference>
    <dbReference type="GeneID" id="56531020"/>
    <dbReference type="KEGG" id="bps:BPSS0531"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6692"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GSGCEWE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="364"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="552" mass="59664" checksum="9E958015E485CF30" modified="2004-10-25" version="1">MLDRAAANPDLVTRVPTLSSLSSAAMTSSAVSTTGTTNTVASGGAAAGAPSFAPPAADAFPQADGAPRNPAVLQFPVPGGAPAPADARVAAPVVYSAQGEQAAIMKAGLQQASWNNPFVSHALPAVLQLQRHLAAGPLNQAAIRTQLGLEVRLYRERLAASGCEWEQIRDASYLLCTYLDETVNDAAREHAQVVYDGERSLLVEFHDDAWGGEDAFADLSRWMKTEPPPIPLLSFYELILSLGWQGRYRVLDRGDVLLQDLRSQLHALIWHHVPPEPLGTELVAPAKRRRSWWTAGRAAAVALGVLVLAYGAISFWLDSQGRPIRNALAAWMPPTRTINIAETLPPPLPQILTEGWLTAYKHPQGWLLVFKSDGAFDVGKANVRADFMHNIERLGLAFAPWPGDLEVIGHTDSRPIRTSEFPDNQALSEARARNVADELRKTALPGGARAPENAVQRNIEYSGRGDAQPIDTAKTAAAYERNRRVDVLWKVIPDGAQQSGRSLNLQQPEKPGQVPMRPAMPEGVEIAPDGQLPYATSTTMPATRPTTEGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N52</accession>
    <name>Q63N52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme chloroperoxidase</fullName>
            <ecNumber evidence="2">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpo</name>
        <name evidence="2" type="ordered locus">BPSS0444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.10" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529955.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110467.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0444"/>
    <dbReference type="ESTHER" id="burps-q63n52">
        <property type="family name" value="Haloperoxidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37900">
        <property type="protein sequence ID" value="CAH37900"/>
        <property type="gene ID" value="BPSS0444"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0444"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6586"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EDQMLFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="273" mass="29332" checksum="6044D32E26E94E8E" modified="2004-10-25" version="1">MDTITTKDGTRIFYKDWGAGRPVVFSHGWPLNADAWDAQMLFLAQRGYRAIAHDRRGHGRSGQPATGNDMDTYADDLAALLDALDLREATLVGHSTGGGEVARYIGRHGSKRVAKAVLIGAVPPIMLQTEANPGGLPMEAFDGIRRGVAGNRSQFYRDVALPFFGFNRPDAQVSQATIDAFWAQGMTGGILGQYACIREFSEVDYTADLKKIDVPTLILHGDDDQMVPIDASARLSAKLVAGATLKVYPGGSHGICVTHADEVNADLLAFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NI0</accession>
    <name>Q63NI0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110339.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0319"/>
    <dbReference type="EnsemblBacteria" id="CAH37767">
        <property type="protein sequence ID" value="CAH37767"/>
        <property type="gene ID" value="BPSS0319"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0319"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4309"/>
    <dbReference type="eggNOG" id="ENOG503335K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YDTVAPQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="23037" checksum="0CF8CACA340991D7" modified="2004-10-25" version="1">MLHWGFRRGARMSPDHPWNSLEIVKLAAEVLTPVSVAAFGWLVSHRLKQLELVQWTNQKLIEKRLALYDTIAPLLNRLLCFYTWVGPWKDISPDDVIRAKRELDQTIHIYRHLFDDDVYRAYQAYLDALFDTHSGAGRDARIKSTIASPDGDRIGNGTYRWNPAWAERFTDANVASRDEVRARYQRIMDGLRISLGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NK0</accession>
    <name>Q63NK0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fatty-acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529844.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110319.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0299"/>
    <dbReference type="EnsemblBacteria" id="CAH37747">
        <property type="protein sequence ID" value="CAH37747"/>
        <property type="gene ID" value="BPSS0299"/>
    </dbReference>
    <dbReference type="GeneID" id="56531241"/>
    <dbReference type="KEGG" id="bps:BPSS0299"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6405"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMRCESE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="621" mass="66831" checksum="94557D88E4328771" modified="2004-10-25" version="1">MSSIQSALAACRSLTAPPPLAPAANFADVLRYRAETTPDEFAYGYLGFGRMPDRVMRYGDIHRRALGIAREIVAHGRPADPVLLIFPSAADFVEAFFGCLYAGRMAVPALPPRTEKERRRLISIARDCAPSFAICGNGEMDAVLAELCAAGVVAPPCREVGAIADGGDIGDAPGALPAIAPGSIAFLQYTSGSTSDPKGVMVGHDNLLANERLLRRHWGSDRERWLIVSWLPHYHDMGLIGGILQPIYAGRPAVFMSPQDFLQHPARWLHAVSDYGATCSGAPNFGYELCRRRASRMDLARLDLSTWEQAFNGAEPVRPRTLREFADAFACAGFRYDAFAPCYGLAELTLAATSKQIGESVVIRRADRAALAAGRFEPQQDGGRSVDAVSVGALEHAHQTFCIVDPATGEPQPTGAIGEICVASDSVCHGYFGRPDATEATFHAYRSSAFPDGMLRTGDLGFIDEAGHLFVSGRIKDLIILNGVNYYPQDIEGAVLNVSDQIRANRLAAIMVERDEQAGVVVVLEAIGRFDLAALAPEIAREVWDACQLTLSGVIRVKKGEIHTTSSGKIQRATCAKMLADGAFTIEDAHLHDTARAWLAPVVERCGRACREPSADTPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NP0</accession>
    <name>Q63NP0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531484.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110279.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0260"/>
    <dbReference type="EnsemblBacteria" id="CAH37706">
        <property type="protein sequence ID" value="CAH37706"/>
        <property type="gene ID" value="BPSS0260"/>
    </dbReference>
    <dbReference type="GeneID" id="56531285"/>
    <dbReference type="KEGG" id="bps:BPSS0260"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6347"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLDWVKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="334" mass="34756" checksum="66D7B17D8970B6B3" modified="2004-10-25" version="1">MNRVINHPDYVVEDMLRGIVAAHPALALDADNPRVIGVAHPVPGKVGVVTGGGSGHEPAFVGYTGPGLVDAVAIGEIFSSPTAKSFLDAFRRADRGAGVACLYGNYAGDNMNVKMAIKMAAAQGIDVKTVVANDDVASAPREERAKRRGVAGEILMWKAGGARAAAGGDLDAVIASAKKAIDNTRSVGIGLSACTIPANGKANFHIADGEMEVGIGHHGEHGVRVMRTVSAKDMAAMMLDIVLPDFPLERGEEVAVLVSGLGATPLMEQYILYAEVSQRLAAAGLKIGFRLVGNLFTSLEMMGVTLTVTRLDDELKQLFAAPCSSIGLTVGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NS2</accession>
    <name>Q63NS2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205370.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110247.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0227"/>
    <dbReference type="EnsemblBacteria" id="CAH37672">
        <property type="protein sequence ID" value="CAH37672"/>
        <property type="gene ID" value="BPSS0227"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0227"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6305"/>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QQPPAEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008023">
        <property type="entry name" value="DUF748"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05359">
        <property type="entry name" value="DUF748"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1319" mass="138671" checksum="138F390A68738EBE" modified="2004-10-25" version="1">MAFNKETVQSNLQKLGVAARSRRAKRAGIGALIFLVAFGLLGFFAAPPLIRHVAEQQLSQQLERPATIARIAFNPYTLRLEADGVRVGERGGQGAFVDIGKLVVRASWTSLARFAPIIDEVRLDQPRFRIVRYDAQRFNFTDLVDKFSKPSPQPSAKPARFSVSNIQVNDGRIEFDDRLLNARHVVDQWTVGIPFIATLPSKTDIFVEPKLRARLDGSPIAIDGKTKPFAQSRESSINLKFDGLDVPRLLSYAPTKLPVDVRSGRLSSNLDVNFAMAGDTPSLRVSGTLDLNDAQVTSRANEPLFAAHAVHVAAAQLEPLRNVLHFDDIRIDRPVVSLARDKAGVLNVMKLAGGEKAGAPPAARAAAPTSAGASAAAAGSSVSAVSPGSPAAARPASGAASQPAAAASSAAAAHAAAEKAPPLDLTIKRFAINDGALNLNDASLATPAAISLQHVATTLADFTLAGKTPARYTLAADVASGGSLKAEGAFSLAARQADTKLAIDALALPAVQPYLAGASSARVLDGVLSTSVNAKADWSKTPLDAQVSDSELGLKSLKIALPNAKTPAVALPDARVKVTKIDLAARTAEIASVDATGLALDVARLQDGRIDLASLAGDGGRAAGAKPAASNASAARGARPAAPAWRYRIDELNVKDAKANFTDRSTPRPVKLAIAPLALNVRQISEDLSKPLPVRLTATLNRKGSLELSGNVTAQPLKVGLKLNGNRLDAAAFEPYFGSMLNATVASALLNAKGELSVEQAKQSTKASYRGDAALVDVRMLDKATSDPFAGWRSLALANLKASYDDARGTDVDASRVTFSNFYGRVLLDAQGKLNLREVVAKESGPAQSLTRDASGKEPIPLTPQAASQAKAAIAASAVEPASAPVLASAAAASAAAAAGASAVAASPASGAAVVRAAAPPQHPVRLHFGQLLLQRGRVTYTDNFIKPNYTANLVAINGTIGAFGTDSTAPAPVDVGANLAGNGPITIKGTVNPLIEKPSLDLTATAHDIELTNLTPYSAKYAGYPITKGKLNVDLHYKLDNDLLSANNHIFIDQLTFGEHVENDTATKLPVRLAIALLKNSRGEIDVNVPVSGSLSNPEFSIGGLIWRAVLNLIAKAVTSPFTLLAHAFGGDGEALGYVEFEPGRSKLSDASQKKLDTISKMLAEKPSIRLDLIGRVDPDKDLPGLRDAYVERLVRQQKLKDVVGQGESVDPMTVKVDPAEYTKYLTKAYKAADFKKPRNMIGFTKTLPDDDMKKALADHASVDDSSLRALAQARAQAVRQYLEGKVDSSRMFIVAPKLDAKGIEDKGATTRVDFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PN6</accession>
    <name>Q63PN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200038.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109933.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="burma-q62fx7">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37350">
        <property type="protein sequence ID" value="CAH37350"/>
        <property type="gene ID" value="BPSL3337"/>
    </dbReference>
    <dbReference type="GeneID" id="56593955"/>
    <dbReference type="KEGG" id="bps:BPSL3337"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1871"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESYLMHD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="273" mass="29705" checksum="9F563310107B2393" modified="2004-10-25" version="1">MPFVTIDGQPLHYQIRGAGAPVLFGHSYLWDSSMWEPQLDALSKSYRVIAPDLWGHGRSGPLPDGTRSLDDLARQMSELLDHLDIDTCSIVGLSVGGMWAVPLAHRAPQRIDRLVLMDTYVGVEPDATRNQYFQMLEAIDAQGAIPAPLLDAIVPIFFRPGIDPASELPTGFRRALQAFTTERLRDSVIPLGKITFGREDARAQLSALPADRTLVMCGANDVARPPEEADEIAALIGCEKAFVPNAGHISNLENPAFVTQALSDWLGRGAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PS5</accession>
    <name>Q63PS5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535926.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109894.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3298"/>
    <dbReference type="EnsemblBacteria" id="CAH37311">
        <property type="protein sequence ID" value="CAH37311"/>
        <property type="gene ID" value="BPSL3298"/>
    </dbReference>
    <dbReference type="GeneID" id="56527848"/>
    <dbReference type="KEGG" id="bps:BPSL3298"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1919"/>
    <dbReference type="eggNOG" id="ENOG50330EW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGIAWRG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021267">
        <property type="entry name" value="DUF2844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11005">
        <property type="entry name" value="DUF2844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266519" evidence="1">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="16938" checksum="CF6FBB98637BEBC8" modified="2004-10-25" version="1">MRSSRFRRLAATAAGFMCAWLAAPAHAGLGGAPMTPPAADTAATVRSIQRSIHAAGGASTAAVGYTVRETTLGSGTVVREYVSTAGTVFALSWQGPVAPNLSDLLGAYFPQYEAGVKASRAAHGPRAPAAIDTGGLVIHTGGHMGSYSGQAWLPQALPAGFSTNDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QP8</accession>
    <name>Q63QP8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="8">SDH</shortName>
            <ecNumber evidence="3 8">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">aroE</name>
        <name evidence="12" type="ordered locus">BPSL2976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194401.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109570.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2976"/>
    <dbReference type="EnsemblBacteria" id="CAH36986">
        <property type="protein sequence ID" value="CAH36986"/>
        <property type="gene ID" value="BPSL2976"/>
    </dbReference>
    <dbReference type="GeneID" id="56594225"/>
    <dbReference type="KEGG" id="bps:BPSL2976"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2298"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="10">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="9">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="11">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="8">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="292" mass="30004" checksum="1FC4AA40A1940D77" modified="2004-10-25" version="1">MSTAVESAARARDRYAVIGNPIAHSKSPFIHSRFAEQTGEAIEYTHLLAPLDGFSATVRAFIAQGGRGVNVTVPFKLEAYALADALSPRAAAAGAVNTLRFDADGVFGDNTDGVGLVRDIEVNLGVSLTGARILLLGAGGAARGVVLPMLERGPASLTIVNRTASKAEELVGQFTQAAHDAGCVLAGGGPERIAREPYDVIVNATAGSLDAALPECDAAAFGPATLAYDMMYGARPTVFMEHAAALGARTADGLGMLVEQAAESFHVWRGVRPDSAPVLAALRAALAASAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QX2</accession>
    <name>Q63QX2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109496.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2902"/>
    <dbReference type="EnsemblBacteria" id="CAH36912">
        <property type="protein sequence ID" value="CAH36912"/>
        <property type="gene ID" value="BPSL2902"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2902"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3314"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TEWNVAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="25522" checksum="45A99D940EFEB1C0" modified="2004-10-25" version="1">MTLRFETAPMPTTQILFIRHGETAWNRIKRIQGHIDIPLADTGLAQARQLAERLAREARGGARIDAVYTSDLSRARQTAQPTADALGLPLVPRQALRERAYGVFQGHDSTEIEARFPDAFAQWQTRDPGFEPEGGESHRAFYHRVLHEVERIVAAHPGGRIACVAHGGVLDCVYRFANDLPLDAPRKHALLNTSVNIVDYDDGRARVVRWADVDHLSGASDDDGYRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ0</accession>
    <name>Q63QZ0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194211.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109478.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2884"/>
    <dbReference type="EnsemblBacteria" id="CAH36894">
        <property type="protein sequence ID" value="CAH36894"/>
        <property type="gene ID" value="BPSL2884"/>
    </dbReference>
    <dbReference type="GeneID" id="56593698"/>
    <dbReference type="KEGG" id="bps:BPSL2884"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2408"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PDVLMTL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="228" mass="25268" checksum="C735A5A3EB5FC43F" modified="2004-10-25" version="1">MTRRADRLFQIAELLRGRRLTTAQQLADWLSVSPRTVYRDVRDLQLSGVPIEGEAGIGYRLNRAASLPPLTFTAEELAALAAGARMLETWGGARFAGGARSALAKIASAMPADKRATLDRLAVFAPSFHVDRAFSEKVDALHEAVDGRRIVSFAYCDRLGAQTTRHVWPLGLVYWGGRWTIGAWCELRGDFRTFDIARMSEVAVHGPFPDQEGKRLADYLRKANAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R01</accession>
    <name>Q63R01_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533570.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109467.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2873"/>
    <dbReference type="EnsemblBacteria" id="CAH36883">
        <property type="protein sequence ID" value="CAH36883"/>
        <property type="gene ID" value="BPSL2873"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2873"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3277"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IMIVFPI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="21799" checksum="ED4135408AB656FF" modified="2004-10-25" version="1">MACVAHAYNRARSSSSAFAVRGGAAIGAVVLGTVATYLVLFMPTYGVKELKLAPSAAFAAILVVGVIQMGFAPVVGHWSDRHGRVRTMCVPALAILVLIYPAFAWLAAHPTFGALIAVQIVFAFLMTGYFAALPGLLSEIFPVATRTTGMSLAYNVAVTVFGGFGPFIIAWLIRATGTKAAPSFYLIFAALASLAALVALRRRFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R15</accession>
    <name>Q63R15_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527701.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109453.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2859"/>
    <dbReference type="EnsemblBacteria" id="CAH36869">
        <property type="protein sequence ID" value="CAH36869"/>
        <property type="gene ID" value="BPSL2859"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2859"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2441"/>
    <dbReference type="eggNOG" id="COG3709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGYPYVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009389">
        <property type="entry name" value="DUF1045"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06299">
        <property type="entry name" value="DUF1045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033328">
        <property type="entry name" value="Phest_Mll4975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03223">
        <property type="entry name" value="Phn_opern_protn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="28219" checksum="4279593E6247D662" modified="2004-10-25" version="1">MRAELAARAGAARFALYYAPPRASAWWRAGCAWLGRDPEDGATLAPPQPGALRRPVDALTVAPRRYGWHATLVAPFALRPGIAPDELVAAAAAWARACAPLAIDVDVAALGAFVALRPAHAHGDDALRALAARALRALVPLRRPPADAERAKRAAAPLSERQRALLAEWGYPYVLDEYRFHMTLSDPLDDPAERAALIDWWKAAAAALGPLPVDHAAIFVEARPGAPFMLWKRLPFGQRAAATDAAATTDAADAADAAESGEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R25</accession>
    <name>Q63R25_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphonates-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnD</name>
        <name evidence="4" type="ordered locus">BPSL2849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527693.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109443.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2849"/>
    <dbReference type="EnsemblBacteria" id="CAH36859">
        <property type="protein sequence ID" value="CAH36859"/>
        <property type="gene ID" value="BPSL2849"/>
    </dbReference>
    <dbReference type="GeneID" id="56528349"/>
    <dbReference type="KEGG" id="bps:BPSL2849"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2451"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QGMRFDK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017797">
        <property type="entry name" value="Phosphnate-bd"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03431">
        <property type="entry name" value="PhnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266704" evidence="3">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="331" mass="36220" checksum="5036668BD17D9DA2" modified="2004-10-25" version="1">MKLIRSLVACVAALACAAAAHAQTLNFGIISTDSSAVLKRRWQPLIDDMNRKTGLDVKAFFATDYAGIIEGMRFNKVQLGYFGNASALEAVERSNGEVFAKLRHANGETGYYSVLITNANSRFRTLDDVFRNPKDVTLGFGDPNSTSGTLVPAYYLFAPRGIAPRTAFRTVLPSSHEGNLLAVVNDKIDIATNNTDVLGMLKKQHPDQYARVRVLWTSPQIASDPLVWRKDLPDATKQKLRDFFYNYAKTDPHEQAVMAGIRNLVGFAPSSDAQLIPVRKIVLFQQKQKIETDMALSADARRAQLAALDARLAALDASGAADASSAQADKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R45</accession>
    <name>GRPE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">BPSL2829</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194243.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109423.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63R45"/>
    <dbReference type="SMR" id="Q63R45"/>
    <dbReference type="STRING" id="272560.BPSL2829"/>
    <dbReference type="EnsemblBacteria" id="CAH36839">
        <property type="protein sequence ID" value="CAH36839"/>
        <property type="gene ID" value="BPSL2829"/>
    </dbReference>
    <dbReference type="GeneID" id="56594682"/>
    <dbReference type="KEGG" id="bps:BPSL2829"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2474"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000053559" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="185" mass="19741" checksum="2F19489C87332168" modified="2004-10-25" version="1">MENTQENPTDQTTEETGREAQAAEPAAQAAENAAPAAEAALAEAQAKIAELQESFLRAKAETENVRRRAQDDVAKAHKFAIEGFAENLLPVLDSLEAAVGDTSGDLAKVREGVELTLRQLTSALEKGRVAALNPVGEKFDPHLHQAISMVPADQEPNTVVAVLQKGYTIADRVLRPALVTVAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC3</accession>
    <name>Q63RC3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL2749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ElaB/YgaM/YqjD family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533578.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109345.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2749"/>
    <dbReference type="EnsemblBacteria" id="CAH36757">
        <property type="protein sequence ID" value="CAH36757"/>
        <property type="gene ID" value="BPSL2749"/>
    </dbReference>
    <dbReference type="GeneID" id="56528448"/>
    <dbReference type="KEGG" id="bps:BPSL2749"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2567"/>
    <dbReference type="eggNOG" id="COG4575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KDQAFSE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043605">
        <property type="entry name" value="DUF883_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043604">
        <property type="entry name" value="DUF883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010279">
        <property type="entry name" value="YqjD/ElaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35893">
        <property type="entry name" value="PTHR35893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05957">
        <property type="entry name" value="DUF883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19029">
        <property type="entry name" value="DUF883_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883" evidence="11">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883_C" evidence="12">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="100" mass="10840" checksum="19F746DC486BDBA7" modified="2004-10-25" version="1">MSEVNKEKLMSDIKTVLADAEDLLKQAASSTGDRATELREKALARLKQAKEKATDVQVVVVEKGKKAARATDDYVHEHPWTSIGIAAGVGVLIGLLINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF2</accession>
    <name>Q63RF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR-family regultor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202422.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109316.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2720"/>
    <dbReference type="EnsemblBacteria" id="CAH36728">
        <property type="protein sequence ID" value="CAH36728"/>
        <property type="gene ID" value="BPSL2720"/>
    </dbReference>
    <dbReference type="GeneID" id="56594959"/>
    <dbReference type="KEGG" id="bps:BPSL2720"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2607"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVCMMRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="34865" checksum="660C9282598CCD01" modified="2004-10-25" version="1">MQPDQDRAASLDIWLVRVLRTLLVERSVTQAALRLNQTQPAISAALRKLRDALGDPLLVRGKTGMVPTEYGASLLDAAERALRDVDFVATPHGPFDPDTARRTFRIAAPDYLNDFFMPTLVARFRAAAPHARIEIDSLNPSLDHAGALDSGALDLVIGNWPKPDPRFVRTDLFSDTVVCLMRRDHPLARAPLTRDAYANALHLAPAPYIGARNNAIELGLARAGIARRVAATLPYFGLVPQVLLQSDLIFTTTRRFAIHYARLLPLVVVAPPVPFPRIRCYQLRHPAPDRPTDADWLSALMADVSAELTMRGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RH3</accession>
    <name>Q63RH3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109295.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2699"/>
    <dbReference type="EnsemblBacteria" id="CAH36707">
        <property type="protein sequence ID" value="CAH36707"/>
        <property type="gene ID" value="BPSL2699"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2699"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3075"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHATIGG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266729" evidence="1">
        <location>
            <begin position="29"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="719" mass="66248" checksum="60ED7C5A64EF69E1" modified="2004-10-25" version="1">MKQNFKLTSIALSAAVAFGVAAATPAVAAGLDTLPVSASVTDLGGAGSGSAMLALAGGTQHGSIHASALGSADASISNVALDNLTGTLANAASTLQNAAANNPLSGVASNAVGTLTNLANNNPLPGALSNAVGTLQNAATNNPLSGVASNAVGTLTNLANNNPLPGALSNAVGTLQNAAANNPLSGVASNAVGTLTNLANNNPLPGALSNAVSTLQNAAANNPLSGVANNAVGTLTNLANSNPLPGALSNAASTLQNAATNNPLSGVASNAVGTLTNLANSNPLPGALSNAVSTLQNAAANNPLSGVASNAVGTLTNLANNNPLPGALSNAVSTLQNAAANNPLSGVASNAVGTLTNLANNNPLPGALSNAVSTLQNAAANNPLSGVANNAVGTLTNLANNNPLPGALSNAVSTLQNAATNNPLSGVASNAVGTLTNLANNNPLPGALSNVAGALAGAASNGSGALTGAAGNVTGALAGAGSTAAGAISGAMSNNPLPGVVNNVVGTLANAIGSNPITPITSVASGLANALSVANPAALTAAANTVAGTLARAANGTPVAGAIGGLVAALPVANPAGALTSAANNAASTIATVAGTNPAAAIGGVAGALTGAAGTGVATASQLGSVGSALMGSGAASAGKVLTSGSAAFGSAAASAGSLLTTGAAAASSVVNSLGSSVGAVVASLPNLSVSSSKSTAAASNPLAPVSSTVATLVGALPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX9</accession>
    <name>Q63RX9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189913.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109138.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36549">
        <property type="protein sequence ID" value="CAH36549"/>
        <property type="gene ID" value="BPSL2542"/>
    </dbReference>
    <dbReference type="GeneID" id="56596413"/>
    <dbReference type="KEGG" id="bps:BPSL2542"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2832"/>
    <dbReference type="eggNOG" id="COG2119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PDKMDDD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="190" mass="19973" checksum="F569D584042E56D9" modified="2004-10-25" version="1">MTEAFLISTGAVALAEIGDKTQLLSLVLAARYRKPLPIIAGVLAATLINHGFAGALGEWLGIYLTPAVMRWALALSFIGMGLWILVPDKLDADEANANRSRLGVFGATFVAFFLAEMGDKTQIATVALAARFQDYVGVVAGTTLGMMLANVPAILLGDRFAHRLPTKLVHGIAAVLFIVLGALAFLHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ9</accession>
    <name>Q63RZ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ompA</name>
        <name evidence="5" type="ordered locus">BPSL2522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189892.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109118.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63RZ9"/>
    <dbReference type="STRING" id="272560.BPSL2522"/>
    <dbReference type="EnsemblBacteria" id="CAH36529">
        <property type="protein sequence ID" value="CAH36529"/>
        <property type="gene ID" value="BPSL2522"/>
    </dbReference>
    <dbReference type="GeneID" id="56596437"/>
    <dbReference type="KEGG" id="bps:BPSL2522"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2858"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CWRTGYW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002368">
        <property type="entry name" value="OmpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01022">
        <property type="entry name" value="OUTRMMBRANEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267094" evidence="3">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="224" mass="24078" checksum="0905C06DF21D2EAF" modified="2004-10-25" version="1">MNKLSKLAFIAATAVMAASASAQSVPASRQAVNDNWVNGTGEWVWMNGTNELCWRDAFWTPATANAKCDGALVAQAPAPAPVAPVAPAITSQKITYQADTLFDFDKAVLKPAGKQKLDELAAKIQGMNVEVVVATGYTDRIGSDKYNDRLSLRRAQAVKSYLVSKGVPANKVYTEGKGKRNPVTGNTCKQKNRKQLIACLAPDRRVEVEVVGTQEVQKTTVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S03</accession>
    <name>Q63S03_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.51</ecNumber>
            <ecNumber evidence="7">5.4.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">pheA</name>
        <name evidence="23" type="ordered locus">BPSL2518</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="8"/>
    <dbReference type="EC" id="5.4.99.5" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190098.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109114.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2518"/>
    <dbReference type="EnsemblBacteria" id="CAH36525">
        <property type="protein sequence ID" value="CAH36525"/>
        <property type="gene ID" value="BPSL2518"/>
    </dbReference>
    <dbReference type="GeneID" id="56596441"/>
    <dbReference type="KEGG" id="bps:BPSL2518"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2863"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010957">
        <property type="entry name" value="G/b/e-P-prot_chorismate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01807">
        <property type="entry name" value="CM_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 23" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="20">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="21">
        <location>
            <begin position="93"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="280"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="19">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAH36525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="360" mass="39234" checksum="29BED4429FFE12D9" modified="2004-10-25" version="1">MDDELNSRLKPLRERIDAIDTQLIALLNQRAAVALEVGEVKKHFNAPVFRPEREQQVIARLQDMSAGPLASEHISAIWREIMAASRDLEQTIHVAFLGPVGTYSEQAMFDYFGQSIEGLPCPSIDEVFRSVEAGAATFGVVPVENSSEGAVSRTLDLLLHTQLLIGGELSLPIHHNLLTQTGKLDGVKRVCAHAQALAQCQQWLASNAPHLERQAVASNAEAARLAADDATVAAIAGDRAATHYGLQIAYALIQDDPHNRTRFAVIGQEPAGPSGHDQTSLIVSVKNEPGAVFKLLEPLARHGVSMTRFESRPARVGTWEYYFYIDIEGHRDDAAVQGALAELGRKAAFLKILGSYPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S35</accession>
    <name>Q63S35_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190182.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109082.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2487"/>
    <dbReference type="EnsemblBacteria" id="CAH36493">
        <property type="protein sequence ID" value="CAH36493"/>
        <property type="gene ID" value="BPSL2487"/>
    </dbReference>
    <dbReference type="GeneID" id="56596471"/>
    <dbReference type="KEGG" id="bps:BPSL2487"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2895"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FTCDRPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="196" mass="21156" checksum="DC503EDC019C8C38" modified="2004-10-25" version="1">MNAYTLQSIRYNDAPDALRRRFALLHQRVDPDDAFAPDGPPPVIHDPRLDAMSFYASTRSNGEVVSYAAVVRKTIAHAGKRFSIGGLSWVATDPAHRRAGLGARTVSAATQWMAASGLDIGVFTCDPPLARFYARAGDWPIAAHVTLIGSRAAGALRSDTLNKVVLMRLFTAKARAAEAELSRATIDLDLPPGQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S42</accession>
    <name>Q63S42_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mog</name>
        <name evidence="4" type="ordered locus">BPSL2480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522377.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109075.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2480"/>
    <dbReference type="EnsemblBacteria" id="CAH36486">
        <property type="protein sequence ID" value="CAH36486"/>
        <property type="gene ID" value="BPSL2480"/>
    </dbReference>
    <dbReference type="GeneID" id="56528700"/>
    <dbReference type="KEGG" id="bps:BPSL2480"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2904"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYLTSEW"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="15"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="21753" checksum="7BED896BF60F720D" modified="2004-10-25" version="1">MTTTKRNHPDELVIGLVSISDRASSGVYEDKGIPALAEWLAAALVSPWRAETRLVQDDAPTISATLVELVDTLGCDLVLTTGGTGPARRDVTPEATLAVATKEMPGFGEQMRQISLNFVPTAILSRQVAVIRETADHAALIVNLPGQPKSIKETLEGLRGADGKVEVPGIFAAVPYCIDLIGGPYAQTNPAVCAAFRPKSAVRAPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SR9</accession>
    <name>MUTS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutS</name>
        <name type="ordered locus">BPSL2252</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108847.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SR9"/>
    <dbReference type="SMR" id="Q63SR9"/>
    <dbReference type="STRING" id="272560.BPSL2252"/>
    <dbReference type="PRIDE" id="Q63SR9"/>
    <dbReference type="EnsemblBacteria" id="CAH36254">
        <property type="protein sequence ID" value="CAH36254"/>
        <property type="gene ID" value="BPSL2252"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2252"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2559"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224356" description="DNA mismatch repair protein MutS">
        <location>
            <begin position="1"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="634"/>
            <end position="641"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <sequence length="890" mass="96255" checksum="080EBC31E48DDB38" modified="2004-10-25" version="1">MATQIDASSEAAAATAAAQHTPMMQQYLRIKSEHPDTLVFYRMGDFYELFFEDAEKAARLLDLTLTQRGASAGTPIKMAGVPHHAVEQYLAKLVKFGESAAICEQIGDPATSKGPVERKVVRVVTPGTLTDAALLSDKSDVFLLALCVGHNKRGVASNIGLAWLNLASGALRLAELAPDQLGAALERIRPAEILAADGTIESVPAGMGAITRVPAWHFDIASGTQRLCDQLEVASLDGFGAQALTSANGAAGALLIYAAATQGQQLRHVRSLKVENESEYIGLDPSTRRNLELTETLRGTESPTLYSLLDTCCTAMGSRLLRHWLHHPPRASVAAQARHQAIGALLDAPPNAGLDSLRSALRQIADVERITGRLALLSARPRDLSSLRDTFAALPALRERVAEIASNAAALGRLEAALEPPPGCLDLLTRAIAAEPAAMVRDGGVIARGYDAELDELRDISENCGQFLIDLETRERARTGISNLRVEYNKVHGFYIEVTRGQTDKVPDDYRRRQTLKNAERYITPELKTFEDKALSAQERALARERALYDGVLQALLPHIEGCQRVASGLAELDLLAAFAERARTLDWVAPEFTDEIGIEIDQGRHPVVEAQVEQFIANDCALNPERKLLLITGPNMGGKSTFMRQTALIALMAYVGSYVPAKAARFGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILNDATPHSLVLMDEIGRGTSTFDGLALAWAIARHLLSHNRCYTLFATHYFELTQLPAEFPQAANVHLSAVEHGHGIVFLHAVEEGPANQSYGLQVAQLAGVPAPVIRAARKHLAHLEQQSAAQATPQLDLFAAPPVVDEPECNEPPAATPHPALERLLELDPDDLKPRDALDLLYELHTLARSGPADAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV8</accession>
    <name>Q63SV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192010.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108808.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2213"/>
    <dbReference type="EnsemblBacteria" id="CAH36215">
        <property type="protein sequence ID" value="CAH36215"/>
        <property type="gene ID" value="BPSL2213"/>
    </dbReference>
    <dbReference type="GeneID" id="56595999"/>
    <dbReference type="KEGG" id="bps:BPSL2213"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3233"/>
    <dbReference type="eggNOG" id="ENOG5032Y12">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AEHWMRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021831">
        <property type="entry name" value="ParD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11903">
        <property type="entry name" value="ParD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="74" mass="8011" checksum="B83C1CE0325CC241" modified="2004-10-25" version="1">MGIVKISDGMHESLRHASAALSRSINAQAEHWLRIGMLAELHPTLSYAEICRLLIETEIQGDEAAPSVDAARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV9</accession>
    <name>Q63SV9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">map2</name>
        <name evidence="2" type="synonym">map</name>
        <name evidence="5" type="ordered locus">BPSL2212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197098.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108807.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2212"/>
    <dbReference type="MEROPS" id="M24.001"/>
    <dbReference type="EnsemblBacteria" id="CAH36214">
        <property type="protein sequence ID" value="CAH36214"/>
        <property type="gene ID" value="BPSL2212"/>
    </dbReference>
    <dbReference type="GeneID" id="56595998"/>
    <dbReference type="KEGG" id="bps:BPSL2212"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3234"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGAESCY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="272" mass="29282" checksum="5E132843B90F81DF" modified="2004-10-25" version="1">MARSRQVPIRSKAEIAMARRAGTMAAQVLSMIAPHVKAGVTTNALDRLCREYIVDVLRARPANIGYHGYPKTICASVNHVVCHGIPSDHALQDGDIVNIDVALDHDGWYGDTSRMYCVGEPAAPARRLVDATYEAMMAGIAAVRPGATLGDVGHAIQSVAHREGFSIVREYCGHGIGRIYHDEPQVLHYGRPGAGLRLAPGMIFTIEPMLNAGRAETRQLADGWTVVTQDRSWSAQWEHMVVVTEDGFDILTPWPDGEPARSPAATGAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SY0</accession>
    <name>Q63SY0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-haloacid dehalogenase</fullName>
            <ecNumber evidence="2">3.8.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Halocarboxylic acid halidohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">L-2-haloacid dehalogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11192"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:58314"/>
            <dbReference type="ChEBI" id="CHEBI:137405"/>
            <dbReference type="EC" id="3.8.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.2" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204015.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108786.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2191"/>
    <dbReference type="EnsemblBacteria" id="CAH36193">
        <property type="protein sequence ID" value="CAH36193"/>
        <property type="gene ID" value="BPSL2191"/>
    </dbReference>
    <dbReference type="GeneID" id="56595974"/>
    <dbReference type="KEGG" id="bps:BPSL2191"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3258"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TTFWINR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018784">
        <property type="term" value="F:(S)-2-haloacid dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="27478" checksum="A602B05C3FDB4BC0" modified="2004-10-25" version="1">MPGTPPAFPKAILFDAYGTLFDVHAVVAAAEQLFPGRGDALSQLWRRKQIEYSQLRTLADPAGGRYRPFWELTLDALRFAARALGLALSAAAEKRLMDEYACLSTYPDTVPTLRALRARSTPPKLAILSNGNPQMLDIAVKSAGMSGLFDRVLSVDAVRAYKPSPAAYALGTAAFDAAPADIAFVSSNGWDVAGAGWFGYRTFWLNRTGAPLEELGAAPAGTGAGMAELLAFLDAPRAAAKAGGRARPAPRVSRLGAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T30</accession>
    <name>Q63T30_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108736.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2141"/>
    <dbReference type="MEROPS" id="C83.001"/>
    <dbReference type="EnsemblBacteria" id="CAH36143">
        <property type="protein sequence ID" value="CAH36143"/>
        <property type="gene ID" value="BPSL2141"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2141"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2433"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YNEQTDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="PTHR33447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267118" description="Glutathione gamma-glutamylcysteinyltransferase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C83" evidence="6">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="25671" checksum="FE3AB5CCAD32686A" modified="2004-10-25" version="1">MTVNTRLAGAVLAALALIGPAAAQPLPLPAGLIDLGSLAGEQMLAESGARSAYASLGSHFVTQKTQSYCGVASLVMVLNALRVPAPAAAQYPPFHYFTQDNVLGDATERIRPRALIERHGMTLDQLGALANALGASGDVRHASDVSVDVFRADAIAHLGRPGRYVLVNYLRSRLGQQTGGHISPLGAYDAAADRFLILDVSRYKYPPVWVTTADLYAAMNTPDADSGGRSRGYVLIDGVVAGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T69</accession>
    <name>Q63T69_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">BPSL2100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521239.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108697.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2100"/>
    <dbReference type="EnsemblBacteria" id="CAH36103">
        <property type="protein sequence ID" value="CAH36103"/>
        <property type="gene ID" value="BPSL2100"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2100"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2379"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="650"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="820"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1189" mass="131820" checksum="CF0EAD4E5F1CFD61" modified="2004-10-25" version="1">MKSKDGFYNTSFAAMRRAELVRHPAFANQPLVMSDNASPSQSPVALVKAGQRFAFDGAHGSADALVIARYLAAHRAQVPLLAVICANAVDAQRLAQELAYFAPDARVRVLPDWETLPYDTFSPHQDLVSERLATLHDLGEGRCDILLVPATTALYRMPPASFLAAYTFSFTQGERLDEAKLKAQLTLAGYEHVSQVVRPGEYCVRGSLIDLFPMGSPLPYRIDLFDDQVDSIRAFDPDTQRSLYPVRDVRLLPGREFPFDEAARTAFRSRWRETFEGDPSRAPIYKDIGNGVPSAGIEYYLPLFFDETATLFHYLPERAQLVFTGDLDAAIKRFTADTKQRHAFLSHDRERPILEPQRLFLSDDDFYLLAKPFARIVLPAQPSGGWAAPLPNLALERHADAPLAAFAAYLETTKNRVLFTVESAGRRETIAQLFAEHHLRPAGSDSFAAWLASDERFALGVAPLANGFAVPGEGYAIVTETELYGALGRRAGRRRQEQASNVDAMVRDLSELKVGDPVVHAQHGIGRYMGLVSMDLGEGDTEFLHLEYAGDSKLYVPVAQLHVISRYSGADPDSAPLHALGSGQWERAKRRAAQQIRDTAAELLNLYARRAAREGHAFGLDPRDYVKFADSFGFEETPDQAAAIAAVIGDMTSGKPMDRLVCGDVGFGKTEVALRAAFIAVMGGKQVALLSPTTLLAEQHTQTFADRFADWPVRIVELSRFKTAKEVNAAIAQINEGSVDIVIGTHKLLSSDVQFKRLGLVIIDEEHRFGVRQKEALKALRAEVDVLTLTATPIPRTLGMALEGLRDFSVIATAPQKRLAIKTFVRREEESVIREAMLRELKRGGQVYFLHNEVETIENRKAMLEELVPEARIVIAHGQMHERELERVMRDFVAQRANVLLCTTIIETGIDVPSANTIIMHRADKFGLAQLHQLRGRVGRSHHQAYAYLLVHDPQALTKQAQRRLEAIQQMEELGSGFYLAMHDLEIRGTGEVLGDKQSGEIHEIGFQLYTEMLNDAVKALKNGKEPDLTAPLAATTEINLHAPAILPADYCGDVQERLSLYKRLANCEHGDAIDGIQEELIDRFGKLPPQAHALVETHRLRLAAKPLGIVKIDASEAAIGLQFVPNPPIDPMRIIDMVQKHRHIKLAGQDKLRIETRTPDLAVRVSTVKETLRALGQPQQPRAQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T78</accession>
    <name>Q63T78_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550279.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108688.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2091"/>
    <dbReference type="EnsemblBacteria" id="CAH36094">
        <property type="protein sequence ID" value="CAH36094"/>
        <property type="gene ID" value="BPSL2091"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2091"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3390"/>
    <dbReference type="eggNOG" id="COG4102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARPNIYI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267535" evidence="1">
        <location>
            <begin position="28"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="418" mass="44248" checksum="80885D900FFA32CE" modified="2004-10-25" version="1">MKRRDFLALASLAGAAGVSLPVPYAFAAAQGETSATGAMGAVGAAARAARYSNLLILVELKGGNDGLNTVIPYANPLYRTLRPAIGVKREQVVQLDERAALHPALEPLMPIWRDGRLAIVEGVGYPQPNLSHFRSIEIWDTASRANEYLREGWLTRAFAQASVPPGFAADGIVLGSAEMGPLANGARAIALVNPAQFARAARLAQPVSLRERNPALAHVIDIENDIVKAADRLRPHAGTPALATAFPGGPFGASVKTAMQVLAACDTPQRTPAPGQGVAVLRLTLNGFDTHQNQPGQQAGLLGQLAQGLVAMRSALIELGRWNDTLVMTYAEFGRRARENQSNGTDHGTAAPHFVMGGRVRGGLYGAPPALDALDGNGNLPVAVDFRQLYATVLGPWWGLDAASVLRQRFEPLPLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TG9</accession>
    <name>Q63TG9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative branched amino acid related transport system, bifunctional protein (Membrane and ATP-binding)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL1999</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205105.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108597.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1999"/>
    <dbReference type="EnsemblBacteria" id="CAH35998">
        <property type="protein sequence ID" value="CAH35998"/>
        <property type="gene ID" value="BPSL1999"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1999"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2251"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAVIGPW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="531"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="563"/>
            <end position="570"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH35998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="776" mass="79414" checksum="615E2C56BF3AA186" modified="2004-10-25" version="1">MSSARAVAVRSRLPEALAWLAFVALLVVPALAWPRGWMLGYLAQTAAMIVLALSYNLLLGTTGLLSFGHAAFAGLGAFVAAHGFNRYGLPLPLVPLAGGAAGAAFGALFGFVATRRAGTAFAMITLGIGELVAAAAWSVPEWFGGAGGVSIDRAAGPALAGWEFGKPMHAYALIAAWCVVAAVAMRVLVRTRLARLANAVRDNPARVAALGTDPCRVRFAMAIAAAFFAGVAGALTLIDVEVATAESVGMLRSGAVLFATVIGGTTAFFGPVVGAVLLTFFSVFVASVSRAWLLYLGLLFVAVVLAAPGGASGRWRAWRDARRHGGARFDARRALPGAGAALAGGVAIVFAAELAYALQFAQDDARRAVIGPWRFDAGAPLGWGIAALAAALGVGLAHAARRWGRGAPRTNGPAFADAIDTCGAACGSAELKARDAGDVDGSTNAASAANETNAVSIASTTSMTSTTSTTSTTSMTSMTSMTSATSATSATSATSARHAARVSDNAPSPVFEVAAEPVGGGVHAASAPPALRMADVSKSFGATPVLVGIDLTIRPGERHALIGPNGAGKSTLFNLIAGALAPTRGRIALNGIELGRRRPHAVARLGLARSFQQTSVFARMSVYDNLRCAALHAPRARRRWRRGPAAAAAIDRAADAALASIGLAAHRDALAGSLSYAQQRALDVGLALASGASVFLFDEPTAGMSREQARRTIELIRRATAGKTVLMIEHDMDAVFGFADRVSVLVRGELVATGSPAAIRANAAVRAAYLGEAFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TN9</accession>
    <name>Q63TN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521678.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108527.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1927"/>
    <dbReference type="EnsemblBacteria" id="CAH35927">
        <property type="protein sequence ID" value="CAH35927"/>
        <property type="gene ID" value="BPSL1927"/>
    </dbReference>
    <dbReference type="GeneID" id="56526294"/>
    <dbReference type="KEGG" id="bps:BPSL1927"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4071"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LDFRHFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="67"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="26379" checksum="CBB133159049C547" modified="2004-10-25" version="1">MILFNSFGLLFVVFLLCRKPRGAFAILAAGAALLWLIASGWLAAPLVALAQAGMQPVAHPTMTGDTVIVMLGAGIERRDGVAIPPRDALARIDKTAELYSACRRTAQRCTVVVSGGDPQVRGIAEADTYAPYLLARGVASADLIREKRSHTTYENARFTAPILRAQHYDDLILVTSSYQMKRALLDFERFGFAPQPVYANRRDARLGWLPRAANLANAELALHEIVGVAQFHVYRRLGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TQ1</accession>
    <name>Q63TQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative multidrug resistance protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">emrB</name>
        <name evidence="7" type="ordered locus">BPSL1915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193982.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108515.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1915"/>
    <dbReference type="EnsemblBacteria" id="CAH35915">
        <property type="protein sequence ID" value="CAH35915"/>
        <property type="gene ID" value="BPSL1915"/>
    </dbReference>
    <dbReference type="GeneID" id="56595456"/>
    <dbReference type="KEGG" id="bps:BPSL1915"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4059"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNICYGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="519" mass="55620" checksum="0D48A243771BF2E8" modified="2004-10-25" version="1">MAQPHAPLPPLAGGQLILGTIAVSLAVFMNVLDTSIANVAIPTISGDLGVSSDQGTWVITSFAVANAISVPLTGWLTDRIGQVRLFLASIILFVISSWMCGLAPTLPFLLASRVLQGAVAGPMIPLSQALLLSSYPRAKAPMALALWSMTTLIAPVAGPILGGWISDNYSWPWIFYVNIPVGIAAAAVTWMIYRSRESAVRRAPIDGVGLALLVIWVGSLQIMLDKGKDLDWFASTTIVVLALTALIAFAFFVVWELTAEHPVVDLSLFRMRNFSGGTIALSVGYGLYFGNLVLLPLWLQTQIGYTATDAGLVMAPVGFFAILLSPLTGKFLSRTDPRYIATAAFLTFALCFWMRSRYTTGVDEWSLMAPTFVQGIAMAGFFIPLVSITLSGLPGHRIPAASGLSNFVRIMCGGIGTSIFQTAWDHRNNFHHAQLVEQANPYNPTFNQAVTQMGQLGFTRDQAHGLINNMATQQAAQLGVNDLFYISAAIFVLLIALIWITKPERAGGGDSSAAASAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TR9</accession>
    <name>Q63TR9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193213.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108497.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1897"/>
    <dbReference type="EnsemblBacteria" id="CAH35897">
        <property type="protein sequence ID" value="CAH35897"/>
        <property type="gene ID" value="BPSL1897"/>
    </dbReference>
    <dbReference type="GeneID" id="56595697"/>
    <dbReference type="KEGG" id="bps:BPSL1897"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4040"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYGVMLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="16573" checksum="59BDE9A6F5B8C081" modified="2004-10-25" version="1">MTRALGRLRSPRRQRGATAIEFAILFPMFFLILYGIITYGMIFAAQQSLTLAATEGARAALNYQVAQTQSAALGLRAAAACTAANNLTGWLSGATCTTSTNYTCSYDSTMYCIQVTLTYPYAANPLVPAVALFDAVLPTTLTSRATVQINPTNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TT7</accession>
    <name>Q63TT7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108479.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1880"/>
    <dbReference type="EnsemblBacteria" id="CAH35879">
        <property type="protein sequence ID" value="CAH35879"/>
        <property type="gene ID" value="BPSL1880"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1880"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2120"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HKRANIS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="174" mass="19863" checksum="7D5DDE804E69B879" modified="2004-10-25" version="1">MPTLETDRLWLRPRVLADLDACIEMDRDPDVTRHIAGPWADPVEHRRFVEHRITRAYPPGLGYWSIFEKARPDRFVGWVLLIPDYVEGGRDVEIGWRLVRASWGRGIASEAARRVVRHAFETVRLPRIVADIAAANSASLNVARKLGMRRVGIVQDGIPYVRHRLERADLAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX4</accession>
    <name>Q63TX4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stress-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199454.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108442.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63TX4"/>
    <dbReference type="STRING" id="272560.BPSL1843"/>
    <dbReference type="EnsemblBacteria" id="CAH35842">
        <property type="protein sequence ID" value="CAH35842"/>
        <property type="gene ID" value="BPSL1843"/>
    </dbReference>
    <dbReference type="GeneID" id="56595628"/>
    <dbReference type="KEGG" id="bps:BPSL1843"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3971"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MASYQKI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17602" checksum="F8FF24E2501A18DD" modified="2004-10-25" version="1">MASYKKILLCYDGTLEGRKALRCGADLALELKAETHLLSVVDMRSSIAQSAGLLTDVACSRFEETAREILQEGVNWLTERGVHAQGHFAFGYPIDEIANLATKLNVDLVVVGHRCRSGLSRWWMGAGNTQLLDRVSCSILVACASPAEQKAESAKEGAATIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U00</accession>
    <name>Q63U00_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193553.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108416.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1817"/>
    <dbReference type="EnsemblBacteria" id="CAH35816">
        <property type="protein sequence ID" value="CAH35816"/>
        <property type="gene ID" value="BPSL1817"/>
    </dbReference>
    <dbReference type="GeneID" id="56595606"/>
    <dbReference type="KEGG" id="bps:BPSL1817"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3938"/>
    <dbReference type="eggNOG" id="ENOG502ZF38">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGVPFGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019027">
        <property type="entry name" value="Pilus_biogenesis_CpaD-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09476">
        <property type="entry name" value="Pilus_CpaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266779" evidence="1">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="137" mass="14057" checksum="84D5422278ED7E38" modified="2004-10-25" version="1">MAIRPEHTTRRRASRAVAACAALAALAGCMSGHPPYGMPDASTIGYDARTGLARAPDCAALEQRSQMIDAGRARPGVSFGCATYGNLAAMLARPADLVAPLPYAGADAALGASAVRRYDEGRATPLNPTSTTTSVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UW4</accession>
    <name>Q63UW4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193483.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108102.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1482"/>
    <dbReference type="EnsemblBacteria" id="CAH35483">
        <property type="protein sequence ID" value="CAH35483"/>
        <property type="gene ID" value="BPSL1482"/>
    </dbReference>
    <dbReference type="GeneID" id="56595781"/>
    <dbReference type="KEGG" id="bps:BPSL1482"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3514"/>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFPAKII"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="180" mass="20209" checksum="4B8E8F89E11EE053" modified="2004-10-25" version="1">MTQAFSASSAAAKPARDAEPTPENIRALVDAFYDRVRDDALLGPVFESKLAGRWDQHLPKMGEFWSSLVLGTKSYRGNVQAAHQPLDGLEPVHFSRWLALFLKTVEARYEPAAAVRFMEPALRIAQSLQLSRFGWDYRIPAEQQVILDLIAPKRPDDAAHRPRGEPFPTKIIGRTARDDT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V31</accession>
    <name>G6PI_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="1">GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoglucose isomerase</fullName>
            <shortName evidence="1">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexose isomerase</fullName>
            <shortName evidence="1">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgi</name>
        <name type="ordered locus">BPSL1413</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527211.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108035.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V31"/>
    <dbReference type="SMR" id="Q63V31"/>
    <dbReference type="STRING" id="272560.BPSL1413"/>
    <dbReference type="EnsemblBacteria" id="CAH35415">
        <property type="protein sequence ID" value="CAH35415"/>
        <property type="gene ID" value="BPSL1413"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1413"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3432"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180615" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <sequence length="540" mass="58813" checksum="FDAA623198B30BB6" modified="2004-10-25" version="1">MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRDAMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALHHVATPDIATHFVSNVDGADLARVLERIDPEATLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSANPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPVLQGLVGIWYRNFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAVLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEARKIVGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEHKVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VB3</accession>
    <name>Q63VB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative malonate transport-related system membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107953.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1328"/>
    <dbReference type="EnsemblBacteria" id="CAH35326">
        <property type="protein sequence ID" value="CAH35326"/>
        <property type="gene ID" value="BPSL1328"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1328"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1490"/>
    <dbReference type="eggNOG" id="ENOG502Z7SE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMTATFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044668">
        <property type="term" value="F:sodium:malonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004691">
        <property type="entry name" value="Mal/Na_symporter_MadM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018402">
        <property type="entry name" value="Mal/Na_symporter_MadM_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03818">
        <property type="entry name" value="MadM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00808">
        <property type="entry name" value="malonate_madM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="MadM" evidence="2">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="252" mass="24702" checksum="D867E9FC21A148A4" modified="2004-10-25" version="1">MLGKVVAHNGLVASFALVGCVMFASAALSRKLTLGRVHGSAIAIVIGLALAYAGGAYTGGEKGIADVPLFAGVGLMGGAMLRDFAIVATAFEVQPAQARKAGLVGAVSLLLGTVLPFIVGASVARAFGYSDAVSMTTIGAGAVTYIVGPVTGAAIGANSDVIALSIATGLVKAVIVMVGTPFAAGFMGLRTPRAAMIFGGLAGTVSGVSAGLAATDRRLVPYGALIATFHTGVGCLLGPSLLFFATKAAMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL2</accession>
    <name>Q63VL2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538575.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107854.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1233"/>
    <dbReference type="EnsemblBacteria" id="CAH35227">
        <property type="protein sequence ID" value="CAH35227"/>
        <property type="gene ID" value="BPSL1233"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1233"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.294"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRREYFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267194" evidence="1">
        <location>
            <begin position="29"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="134"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="420" mass="42734" checksum="20235B539E949852" modified="2004-10-25" version="1">MMNRSQQTFAGFAAACAFAAGSAAQAWAAPADAIVYPAGNGSDQADALQAALDALQTGQRLVLAPGQYVVGRSLLVKNAQVVVSGYGATLVATNDADQTIEMRGRDSTLVGVTLVGTGATRLTTPGSTKVDVTGAGVQVLDVEVRGGASAGIFVFGGTDVAVVGNTVRDTLADGIHTTYGSRNVLVRDNTVQNTGDDMVAVVSYKGDGKLSSNVLIQNNTLLGNYWGRGATVVGGADVTITGNTVRNVQKAAGILVGQEDPANTYDARNVIVSNNTISDIEWPDPDNTRPPAYMAAIDVNTWSGKATSVSVTDNRISRARYAGVRALGNVCQLRVSRNALASIDGTPIALQQAPSCAAGQIVCASNTLDGAALASPAGCSATDGLTITGANVARMPQVRAYLRQTAAPSAAKAGTAASGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU4</accession>
    <name>Q63VU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936871.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107772.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1151"/>
    <dbReference type="EnsemblBacteria" id="CAH35145">
        <property type="protein sequence ID" value="CAH35145"/>
        <property type="gene ID" value="BPSL1151"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1151"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.389"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="60" mass="6589" checksum="96BBCFE61F95AF42" modified="2004-10-25" version="1">MSDISIEGKAAQLSALLTSMYGEGFVTFKRLYDDDQEALIWLAADLVDEIKSAVAEVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W95</accession>
    <name>Q63W95_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193782.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107621.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0993"/>
    <dbReference type="EnsemblBacteria" id="CAH34989">
        <property type="protein sequence ID" value="CAH34989"/>
        <property type="gene ID" value="BPSL0993"/>
    </dbReference>
    <dbReference type="GeneID" id="56596197"/>
    <dbReference type="KEGG" id="bps:BPSL0993"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.579"/>
    <dbReference type="eggNOG" id="ENOG50333YU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QQPYVYQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021853">
        <property type="entry name" value="DUF3460"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11943">
        <property type="entry name" value="DUF3460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="62" mass="7629" checksum="9169E3FABBE96CB3" modified="2004-10-25" version="1">MPYQSDITQFLNQLKQQKPTLEEEQRKGRALLWDKQPIDLEERDAQQRARVRQTPYVYYQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WN2</accession>
    <name>Q63WN2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107484.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0859"/>
    <dbReference type="EnsemblBacteria" id="CAH34851">
        <property type="protein sequence ID" value="CAH34851"/>
        <property type="gene ID" value="BPSL0859"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0859"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.928"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRYFAAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="5">
        <location>
            <begin position="344"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="514" mass="55691" checksum="5865F24128517FA9" modified="2004-10-25" version="1">MLIKPFRSIESAATATHNWRRRQILRAGASTLVLGLALPRLAHASSVLGVRVWPARDYTRVTIESDQPLQNTQQLLQGPDRLVVDLNGLELDQALRDLVSKIAPNDPQIQSVRVGQYQPHVVRMVFDLKGSVKPQVFTLPPVGTYKYRLVFDLYPAVAPDPLSDLIAQTERKEQQLNDTLRAQQAQPPTAALNGPTAAPPAATDNSDAFFQRFAQNNPPAAHSARPAPANPPVAQASPPAAPPRPAVKPPPVIARRNDDDSGDTDTYAFTAPKSGRGTVRLLTVAIDPGHGGEDPGAIGGGGTYEKHIALDIAKKLRAKIDAAPNMRAMMTRDADFFVPLNVRVQKARRVGADLFVSIHADAFTTPSARGSSVFALSDHGASSAAARWLANKENSSDLIGGINIKTQDVAVNRALFDMSTTAQIRDSLRYGNYVLREVGGINKLHKGSVEQAGFAVLKAPDIPSILVETAFISNPDEERRLNDDAYRDQMADAIFRGIKRYFSANPPLAKSRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WP2</accession>
    <name>Q63WP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189016.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107474.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0849"/>
    <dbReference type="EnsemblBacteria" id="CAH34841">
        <property type="protein sequence ID" value="CAH34841"/>
        <property type="gene ID" value="BPSL0849"/>
    </dbReference>
    <dbReference type="GeneID" id="56596513"/>
    <dbReference type="KEGG" id="bps:BPSL0849"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.750"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CSRRLDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="18924" checksum="3FBD044A78F870A1" modified="2004-10-25" version="1">MHAITLDATDCRILAVLQEEGRISNLDLAERISLSPSACLRRMRLLEEQGVIERYRACLSREKLGFELEAFVQVSMRNDQTQWHERFAQAVREWPEVVGAFVVTGETHYLLRVLAHNLKHYSDFVLNQLYKTPGVLDIRSNIVLQTLKDEAGPPVALARTGPAIKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WQ1</accession>
    <name>Q63WQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550801.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107465.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0841"/>
    <dbReference type="EnsemblBacteria" id="CAH34832">
        <property type="protein sequence ID" value="CAH34832"/>
        <property type="gene ID" value="BPSL0841"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0841"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.760"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYGSAFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="33004" checksum="1D59F9884799B8F8" modified="2004-10-25" version="1">MTFDLRQLRAFTTIAASGSLGRAADALHVTQPALSRILKRLEEQIGAPLFERHSKGVQLTAIGEALLPHATLLQHEAEHAREEIDALRGLAKGTIKVGAVGSIASLVLPVALGRVLDRWPNLRVVIVEGVWDRLVDALLTHEIDIALSTRVPDTDEVVAIAECRWDDMSHVVAAPDHPLRAAARAPLTLADTRAARWAIPPRGTAPFEQMRAAFDAHGLAPPDIAVETRSVTALKSLVAHAGFLSWMAEPMYRAERRARTIDTLAVEGVAATRTLTAFRRRHGILPGPAARLLEALALLTREPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WW1</accession>
    <name>Q63WW1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">BPSL0780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550822.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107405.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0780"/>
    <dbReference type="EnsemblBacteria" id="CAH34772">
        <property type="protein sequence ID" value="CAH34772"/>
        <property type="gene ID" value="BPSL0780"/>
    </dbReference>
    <dbReference type="GeneID" id="56527041"/>
    <dbReference type="KEGG" id="bps:BPSL0780"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.829"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="293" mass="30766" checksum="17569348CC1C0B24" modified="2004-10-25" version="1">MSILINKDTKVITQGITGKTGQFHTRACREYANGREAFVAGVNPKKAGEDFEGIPIYASVKEAKAETGATVSVIYVPPAGAAAAIWEAVEADLDLAICITEGIPVRDMIEVKDRMRREGRKTLLLGPNCPGTITPDELKIGIMPGHIHRKGRIGVVSRSGTLTYEAVAQLTALGLGQSSAVGIGGDPINGLKHIDVMKMFNDDPDTDAVVMIGEIGGPDEANAAQWIKDNMKKPVVGFIAGVTAPPGKRMGHAGALISGGADTAEAKLEIMEACGITVTRNPSEMGRLLKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WX6</accession>
    <name>Q63WX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helicase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAH34757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204892.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0765"/>
    <dbReference type="EnsemblBacteria" id="CAH34757">
        <property type="protein sequence ID" value="CAH34757"/>
        <property type="gene ID" value="BPSL0765"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0765"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.844"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="870"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1186" mass="130223" checksum="CF72870A7E4A6E7B" modified="2004-10-25" version="1">MPSDLAAERTLAANIPSPVQLRAELEELVQRELLGPRGGPDEEVAETRVQDRYLVGMLSPRNRRLRANEMDVLADDESASGEDGATDDVPLPTDSLSPSSIGLTCTIAGDVQSVLVTGRWGRYKRERSKTQVNDKGNPLTVWKRYPMGNVGHPIALVEGDIAPVPLDISQPEVYLQGRIRKLNGDWVVSLFMVNGQTEGESLKDEMWVFQPELEVAATDGTAVFRRRQLFRDEAKADPVQHAEQMALEMLYRAQVEFAVGHGVAVHGEVVPEEPTRCVRLRTRAMPTYEVPQTTPPTADDIPALADVILDMKALSELADADLFRSLRALPAAYKGWIEKESARIDNPEEELEVYRKVAESAITNCEVACGRISAGIDLLEQDAKSLEAFRFANRAMWQQRIHTLLSEMRRAGRKVNVDELEKSESPSWRPFQLAFVLLNLPGVTQLDHPERSSAPSAIADLLWFPTGGGKTEAYLGLTAYTLGLRRLQGSVGGRLGHAGVAVIMRYTLRLLTLQQFQRAAALICACEVIRRAAPEVWGTEPFRVGLWVGMKTSPNSVADAHQSTLGGRGVGMGSGTGSPLQLTNCPWCGEGLDLGRDVKVETYAQGRARVFTYCSDRLGQCDFSRAKAPDEGIPVLTVDEEIYRRLPALLIATVDKFAQMPWNGMTQMLFGQVDGYCPRHGFTSPCLEDASSHPTKNGLPAVRAVAHGPLRPPDLIIQDELHLISGPLGSLVGLYETAVDKLCTWSIDGKVVRPKVIASTATIRQATEQVRSLFLRDVRVFPPQGLDVRDNFFSLQREPSERYPGRRYVGVSAFGRRLKVALIRVYSAYLAASQALFLRYGKAADPWMTLLGYFNSMRELGGMRRLVDDDIRSRLRDMDSRGLAKRHTPALEELTSRKNSRDIPGLLDRLEYAHDPLLPPHAKSTGKPVRANPLDVVLATNMISVGVDVKRLGLMVVGGQPKGTAEYIQATSRVGRNAQAPGLVCTVYNWGRPRDLSHYERFEHYHATFYQHVEALSVTPFAARAVDRGISAVLAALVRLPASEFNENLAAGRLDGSHAIVKDAIKAISERAASVTQSTAQGQRVEKMLKARIDYWLKRAAPKPGGARLGYQGQRDGTTIPLLEKTGAGDWEDFTCLGSLRDVEPSVGLIMDDKPLDDGYGQGYTAPAPAVVSNTGTPPSTTGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XB1</accession>
    <name>Q63XB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535878.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107254.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0625"/>
    <dbReference type="EnsemblBacteria" id="CAH34618">
        <property type="protein sequence ID" value="CAH34618"/>
        <property type="gene ID" value="BPSL0625"/>
    </dbReference>
    <dbReference type="GeneID" id="56527165"/>
    <dbReference type="KEGG" id="bps:BPSL0625"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.999"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFGMSPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="531" mass="56862" checksum="6FFF5FA08FE9DA47" modified="2004-10-25" version="1">MAVHTAAHHSSGQVLPFRESLLAMLGISFVTMLVALDQTVVGTALPTIVAELRGFDLYAWVATSYLLASVITVPIFGRLGDYYGRKPFVIASLVVFTGASVLCAMAQDMLSLVLARGLQGIGGGMLVGTAFACIPDLFPDSVVRLRWQVLMSSAFGIANAVGPSLGGVLTQNYGWRAVFYVNLPVGLLSIFFVWRYLPHMRHVEHTRKMRLDWPGALLIAVTLGAMQLFVEWLPKYGIGGWPTLLLVAALAGGVALWRWEKRCAQPILPFDMFSNRALSTLFILAILAGFAMFSLLFYAPLLFQGGFGMSPQQAGVVITPLVVFITIGSIMNGRVITRIRRPNAMLYVGFLLFALACAGVVASTHATPGWALMALMVAGGVGLGFVLPNLTVFAQQTAGREHLGIATALLQSLRMVGGMLGTALTGTLVNQLYANGVRDALAADGALRWQARLADPQVLIDRAAQSRVVDELVRAGHHGAHLLEAARESLVGAIHIGIGVGAFVALAAVWQSRCVPPVELRRKLEPAVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XE1</accession>
    <name>Q63XE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107224.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0595"/>
    <dbReference type="EnsemblBacteria" id="CAH34588">
        <property type="protein sequence ID" value="CAH34588"/>
        <property type="gene ID" value="BPSL0595"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0595"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.645"/>
    <dbReference type="eggNOG" id="ENOG5033Z1I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFEKATA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="121" mass="13257" checksum="B6F6BFF18F4B2C56" modified="2004-10-25" version="1">METAMGFYGPEPFERATATYVWLGLRVPGALIVEVEGNAPRYTTGIQLVRDPRFVGGLKIDVMGWTGPLSSGTQSYKVRHTFQGVFHPTIVVHGSNKTEVVEVKQIPHEEADAFLQALDAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XM3</accession>
    <name>COAD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="ordered locus">BPSL0516</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195249.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107142.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XM3"/>
    <dbReference type="SMR" id="Q63XM3"/>
    <dbReference type="STRING" id="272560.BPSL0516"/>
    <dbReference type="EnsemblBacteria" id="CAH34506">
        <property type="protein sequence ID" value="CAH34506"/>
        <property type="gene ID" value="BPSL0516"/>
    </dbReference>
    <dbReference type="GeneID" id="56593817"/>
    <dbReference type="GeneID" id="66545995"/>
    <dbReference type="KEGG" id="bps:BPSL0516"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1131"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156187" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="166" mass="18530" checksum="C9CDDE2E32564B58" modified="2004-10-25" version="1">MVVAVYPGTFDPLTRGHEDLVRRASSIFDTLVVGVADSRAKKPFFSLEERLKIANEVLGHYPNVKVMGFTGLLKDFVRANDARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFMTPSDQYQFISGTIVREIAQLGGDVSKFVFPSVEKWLTEKVAAMAQGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XW6</accession>
    <name>Q63XW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522920.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107049.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0424"/>
    <dbReference type="EnsemblBacteria" id="CAH34412">
        <property type="protein sequence ID" value="CAH34412"/>
        <property type="gene ID" value="BPSL0424"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0424"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1237"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYMTMVT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266660" evidence="8">
        <location>
            <begin position="31"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="571" mass="60539" checksum="FB13CA4CCC2FD23A" modified="2004-10-25" version="1">MLRQSTARCARLMPAALFACAALAPAAARAMGAAAAPMPEKVAPNPVAIGMFFVFVFATLALTRWAARRTRSARDFYTAGGGITGLQNGLAIAGDYMSAASFLGLSGMVFMFGFDGLIYSIGFLVGWPFVMFLIAEPLRNLGKFTFVDVVAYRFAQRPIRLLTSASALTIVVLYLVVQMVGAGKLIQLLFGLSYGVAELIVGVLMVVYVFFGGMTATTWVQVIKAVLLLAGATLLAALALGEFGFSLDEMFRRAVAVHPGALGIMGPGKLIRDPANALSLGIALMFGTAGFPHILMRFFTVPNAKEARKSVLYATGFIGYFYLLTFVIGFSAIVLLAQHPEFFRHDAAGAFNLTRDLVGGSNMVAVKLAQAVGGNWFYGFIAAVTFATILAVVAGLTLAGATTISHDLYAQMWARGKPHERREMRISRAATLALSAVAIGLSILFEHVNVAFMVGLVAAVAASANFPVLATSIFWRGMTTRGAVAGGGLGLASAVALTVLSKSVWVDVLHHAHAPVFLDNPALVSVPLAFAGIVIGSLTDRSERARRERDAFARQEFYAQTGALATRAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y79</accession>
    <name>Q63Y79_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cation efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">silA</name>
        <name evidence="4" type="ordered locus">BPSL0309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004542866.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106936.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0309"/>
    <dbReference type="EnsemblBacteria" id="CAH34298">
        <property type="protein sequence ID" value="CAH34298"/>
        <property type="gene ID" value="BPSL0309"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0309"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1380"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NSWTYPI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="924"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114673" checksum="9EA5FFA1B17E4C26" modified="2004-10-25" version="1">MIAHVIRWSIRNRLLVLLATALVAAWGVVSLNRTPLDALPDLSDTQVIVKASYPGKAPRVVEDQVTYPLTTTLLGVPGAKTIRAYSSFGDAFVYVLFDDRTDQYWARSRVLEYLNQVQGRLPQGASVALGPDATGVGWVYEYALVDRSGRRDLGELRALNDWFLKFELKAVPDVAEVASVGGMVRQYQVVLDPDRLRAFGITQAAVADALGKANSESGGSVVEMAESEYMVRASGYLRSLDDFRNVVLRTSESGTPVLLGDVARVQIGPEMRRGIAELNGEGEVAGGVIVMRSGKNALSTIEAVKAKLAELRRSLPAGVELVTTYDRSQLIGRAVDNLKDKLIEEFVVVGLVCALFLFHLRSAFVAILSLPLGVLAAFIVMRHQGVNANLMSLGGIAIAIGAMIDAAVVMIENAHKHLESHEHAHPGAPLSSAARWELIAASAAEVGPALFFSLLIVTLSFVPVFALEGQEGKLFAPLAFTKTYTIAAAAGLSVTLVPVLMGYLIRGRIPREASNPLNRLLVRLYRPLLEATLARPWRAIAIAAAALVLTAIPMSRLGGEFMPPLDEGDLLYMPTALPGISAQKAAELLQQTDRLIKTVPEVATVFGKSGRADTATDPAPLEMFETTIRFRPRGEWRPGMTPGRLVDELDRVVKVPGLSNVWVPPIRNRLDMLSTGIKTPVGVKIAGPELAQIDRIAAQVEAAVKRVPGVTSALAERLNGGRYVDVDIDRRAAARYGLSVGDVQAVVASAIGGENVGEVIAGRERFPINIRYPREVRDSLEKLRALPIVTERGAQILLRDVAAVTIADGPPMIRSENARLSGYVYVDIRGVDLKTAVGAMQRAVAQQVALPPGYSIAWSGQFEYLERAAATLRTVIPVTLAVIFVLLFLTFDSAADALLLMTTVPFALVGGLWFVWALGHAVSVATAVGFIALAGVAAEFGVVMLLYLKRAYERRIAAGEPPNEATLADAIREGAVLRVRPKAMTVAVVLAGLVPIMIGHGSGSEVMQRIAAPMVGGMVTAPLLSMFVIPAAWLLLQRRRMRGAVRAASQAPVAGAAGADFSSIHTGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YA1</accession>
    <name>Q63YA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185161.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106914.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0287"/>
    <dbReference type="EnsemblBacteria" id="CAH34275">
        <property type="protein sequence ID" value="CAH34275"/>
        <property type="gene ID" value="BPSL0287"/>
    </dbReference>
    <dbReference type="GeneID" id="56594362"/>
    <dbReference type="KEGG" id="bps:BPSL0287"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1417"/>
    <dbReference type="eggNOG" id="COG2824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SCLYEWN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="114" mass="12045" checksum="59687BBCBE5A2CBD" modified="2004-10-25" version="1">MSTLPACPQCAMENTYPDGEHYICADCGHEWPIAGDANAADDDAAAVVKDANGNVLADGDAVVLIKDLKVKGSSITLKMGTKVKSIRLVGGDHEVDCKMDAGNFMLKACYLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YD5</accession>
    <name>Q63YD5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative dipeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dppF</name>
        <name evidence="10" type="ordered locus">BPSL0253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523051.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106880.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0253"/>
    <dbReference type="EnsemblBacteria" id="CAH34241">
        <property type="protein sequence ID" value="CAH34241"/>
        <property type="gene ID" value="BPSL0253"/>
    </dbReference>
    <dbReference type="GeneID" id="56527504"/>
    <dbReference type="KEGG" id="bps:BPSL0253"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.271"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="37299" checksum="89C733CED259004E" modified="2004-10-25" version="1">MNAVHETRESAARNDVVLVADQLAKHYAVRRGMFGHGTVKALNGVSFSLARGKTLAVVGESGCGKSTLARQLTMIEPPSAGHLSIDGRDVAGADRETVAALRRRVQMVFQNPFASLNPRKTVEQTLAEPLAINTRLTAAERAQRIAQIMRTVGLRPEHAKRYPHMFSGGQRQRVAIARAMILDPQIVVADEPVSALDVSIQAQILNLFMDLQEQFKTSYVFISHNLSVVEHIADDVMVMYFGSVAELGDKKTIYARPRHPYTRALMSATPAIFEADRKIQIKLQGEMPSPLNPPSGCAFHQRCPYAVERCRVEEPKLRDVDGRLVACHRAEEVGEANA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YH5</accession>
    <name>METK_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine synthase</fullName>
            <shortName evidence="1">AdoMet synthase</shortName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metK</name>
        <name type="ordered locus">BPSL0212</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E53851" last="E53851">
            <title>Combining functional and structural genomics to sample the essential Burkholderia structome.</title>
            <authorList>
                <person name="Baugh L."/>
                <person name="Gallagher L.A."/>
                <person name="Patrapuvich R."/>
                <person name="Clifton M.C."/>
                <person name="Gardberg A.S."/>
                <person name="Edwards T.E."/>
                <person name="Armour B."/>
                <person name="Begley D.W."/>
                <person name="Dieterich S.H."/>
                <person name="Dranow D.M."/>
                <person name="Abendroth J."/>
                <person name="Fairman J.W."/>
                <person name="Fox D."/>
                <person name="Staker B.L."/>
                <person name="Phan I."/>
                <person name="Gillespie A."/>
                <person name="Choi R."/>
                <person name="Nakazawa-Hewitt S."/>
                <person name="Nguyen M.T."/>
                <person name="Napuli A."/>
                <person name="Barrett L."/>
                <person name="Buchko G.W."/>
                <person name="Stacy R."/>
                <person name="Myler P.J."/>
                <person name="Stewart L.J."/>
                <person name="Manoil C."/>
                <person name="Van Voorhis W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23382856"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0053851"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199069.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106840.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3IML">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="A/B/C/D=1-395"/>
    </dbReference>
    <dbReference type="PDBsum" id="3IML"/>
    <dbReference type="AlphaFoldDB" id="Q63YH5"/>
    <dbReference type="SMR" id="Q63YH5"/>
    <dbReference type="STRING" id="272560.BPSL0212"/>
    <dbReference type="EnsemblBacteria" id="CAH34199">
        <property type="protein sequence ID" value="CAH34199"/>
        <property type="gene ID" value="BPSL0212"/>
    </dbReference>
    <dbReference type="GeneID" id="56594441"/>
    <dbReference type="KEGG" id="bps:BPSL0212"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1505"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q63YH5"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000174505" description="S-adenosylmethionine synthase">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="4"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="92"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="250"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="296"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="312"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="363"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="372"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="2">
        <source>
            <dbReference type="PDB" id="3IML"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3IML"/>
        </source>
    </evidence>
    <sequence length="395" mass="42641" checksum="5BE3808C1364B8C3" modified="2004-10-25" version="1">MANDYLFTSESVSEGHPDKVADQISDAILDAILAQDKYSRVAAETLCNTGLVVLAGEITTTANIDYIQIARDTIKRIGYDNTDYGIDYRGCAVLVAYDKQSPDIAQGVDRAHDNNLDQGAGDQGLMFGYACDETPELMPLPIHLSHRLVERQANLRRDGRLPWLRPDAKSQVTVRYVDGKPHSIDTVVLSTQHAPEIDLPALREAVIEEVIKPTLPADLIKGDIKFLVNPTGRFVIGGPQGDCGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLASRALIQVSYAIGVAEPTSVMVNTFGTGRVSDETITKLVREHFDLRPKGIIQMLDLLRPIYEKTAAYGHFGREEPEFSWEAADKALALAEAAGVEPAVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YL9</accession>
    <name>Q63YL9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage head completion/stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556517.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106796.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0168"/>
    <dbReference type="EnsemblBacteria" id="CAH34155">
        <property type="protein sequence ID" value="CAH34155"/>
        <property type="gene ID" value="BPSL0168"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0168"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1554"/>
    <dbReference type="eggNOG" id="ENOG5032SDV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NNSFWPD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009225">
        <property type="entry name" value="Phage_head_completion_GpL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05926">
        <property type="entry name" value="Phage_GPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="17000" checksum="E97B295440BF9DC4" modified="2004-10-25" version="1">MNSFVATAAPAVAATPIEGALTNDGFFPDIDLSALRDAMRLDGTVTAERLRHAARDALLTVNDELAAWRARQRAAGAATLADVPAPRIDGESAHVARYRRAVYHLTHADVTEKYRGYDTTKSGGQVAADLAATVDDSRRAARWAISDILGIARSTVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YN0</accession>
    <name>Q63YN0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204759.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106785.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0157"/>
    <dbReference type="REBASE" id="10394">
        <property type="entry name" value="M.BpsKORF157P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34144">
        <property type="protein sequence ID" value="CAH34144"/>
        <property type="gene ID" value="BPSL0157"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0157"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.168"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFCSYRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="252" mass="27867" checksum="DE9E7228CE3EFB48" modified="2004-10-25" version="1">MTIHATDAAPAADLSPLLDRLHAMDALTLARMLPDASIDMVFTDPPYSSGGLHTSARSRPPSTKYINSDTKTVYTDFESDNMDQRAWAFWCHAWLSECRRALKPGGLLVSFIDWRQLPTLTDVVQAAGLILRGVAVWDKTPGRTRPRRGGFAQQAEFVVWASRGVMRDCEVYLPGVFPCRLPLPKQHVTEKPLDIAREVVRLVPAGGVVCDLFAGSGTFLVAAREVGLHWIGSETNQTYRSLACNRLMQPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YN3</accession>
    <name>Q63YN3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204758.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106782.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0154"/>
    <dbReference type="DNASU" id="3093444"/>
    <dbReference type="EnsemblBacteria" id="CAH34141">
        <property type="protein sequence ID" value="CAH34141"/>
        <property type="gene ID" value="BPSL0154"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0154"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1567"/>
    <dbReference type="eggNOG" id="COG3948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YCTAIDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014507">
        <property type="entry name" value="Baseplate_assembly_J_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020481">
        <property type="entry name" value="BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="110"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="301" mass="32806" checksum="3F067FE304A38398" modified="2004-10-25" version="1">MRSTPIDLSQLPAPDIVDPLDFETLFAERKARLVSLYPPEHQAEIAATLALESEPVTRVLQENAYREVLLRQLINDKARGLLLAYARGTTLDHIAALFDVERLVVTAADPEHGIDAVYEDDDSLRERVQLAPRGFSVAGPEEAYVFHARSADGRVLSAAAFSPEPCVMVITILSREGDGTASDELIEIVRKNLEGKRPQTDEVIVQSAKIVRYAIRATLRFFSGPDRGVALAEARKRTAKFAADMRRIGMEITVDGLHAAMRVAGVQKVLLDSPAGGVPVTHEQAPYCTGIELIDGGVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YQ5</accession>
    <name>Q63YQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524469.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106760.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0132"/>
    <dbReference type="EnsemblBacteria" id="CAH34119">
        <property type="protein sequence ID" value="CAH34119"/>
        <property type="gene ID" value="BPSL0132"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0132"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1589"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="68" mass="7818" checksum="E18770068693787C" modified="2004-10-25" version="1">MNLFAEPLPSDDMDADIRYRRACRYVMFDQIAELRALKRHGYFPWSHAALCIDVCSRLNALGGLAGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS7</accession>
    <name>Q63YS7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523107.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106738.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34097">
        <property type="protein sequence ID" value="CAH34097"/>
        <property type="gene ID" value="BPSL0112"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0112"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1615"/>
    <dbReference type="eggNOG" id="ENOG503176K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNGWDIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="94" mass="10260" checksum="E7C6FD643D380EAA" modified="2004-10-25" version="1">MKTIGRILLALVLTWPLLTGISSLPLLTHWFANGGEGWNALSPVFRALGSDGGEQNEEIFVGILLVISFVLALVLSFALFGLVDRLRHSTDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YU8</accession>
    <name>Q63YU8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Putative transposase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0091</name>
        <name evidence="2" type="ordered locus">BPSL0950</name>
        <name evidence="3" type="ordered locus">BPSL1658</name>
        <name evidence="4" type="ordered locus">BPSL3116</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106717.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107579.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108268.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109709.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63YU8"/>
    <dbReference type="STRING" id="272560.BPSL0091"/>
    <dbReference type="EnsemblBacteria" id="CAH34075">
        <property type="protein sequence ID" value="CAH34075"/>
        <property type="gene ID" value="BPSL0091"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34946">
        <property type="protein sequence ID" value="CAH34946"/>
        <property type="gene ID" value="BPSL0950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35655">
        <property type="protein sequence ID" value="CAH35655"/>
        <property type="gene ID" value="BPSL1658"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37126">
        <property type="protein sequence ID" value="CAH37126"/>
        <property type="gene ID" value="BPSL3116"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0091"/>
    <dbReference type="KEGG" id="bps:BPSL0950"/>
    <dbReference type="KEGG" id="bps:BPSL1658"/>
    <dbReference type="KEGG" id="bps:BPSL3116"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1641"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGMPIKE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9961" checksum="B235077C5372AEC2" modified="2004-10-25" version="1">MKKRFTEQQIIGFLKEAEAGMPVKELCRKHGFSDASFYTWRAKFGGMEVSEARRLKDLEVENARLKKLLAEAMLDMEALKVVVKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YV1</accession>
    <name>Q63YV1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106714.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0088"/>
    <dbReference type="EnsemblBacteria" id="CAH34072">
        <property type="protein sequence ID" value="CAH34072"/>
        <property type="gene ID" value="BPSL0088"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0088"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.99"/>
    <dbReference type="eggNOG" id="COG4849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDILMWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014513">
        <property type="entry name" value="UCP021525"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021525">
        <property type="entry name" value="UCP021525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="305" mass="33198" checksum="BA39355D51197706" modified="2004-10-25" version="1">MLEVPVDRPVEALTIALLRDVKHACAQLGAKFVLAGATARDILMWHLHDIRAPVATRDVDVAVCAVSWESHDALIELLVQTQRFRRHSKQQQKLLFKRSAEDYEGELDIVPFGQIEGPPGEIHWPPDGDIVMTVLGFQEAVDTAQPVSIGEGLVVPVVTLPAFVLLKLIAWKDRRLMKNTDSADLLFVLRNYIDAGNIERTYEQATDLLKAANFDAGLAAAGLLGRDVRGLAYPDTRAALRALLQSADAYETLRLDLQARAAMLLGGFIDDSDALLAAFARELLTEENGSLNGTGPQVGSTGARA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YW2</accession>
    <name>YIDD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL0077</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198815.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106703.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YW2"/>
    <dbReference type="STRING" id="272560.BPSL0077"/>
    <dbReference type="EnsemblBacteria" id="CAH34061">
        <property type="protein sequence ID" value="CAH34061"/>
        <property type="gene ID" value="BPSL0077"/>
    </dbReference>
    <dbReference type="GeneID" id="56596740"/>
    <dbReference type="KEGG" id="bps:BPSL0077"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.87"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000253088" description="Putative membrane protein insertion efficiency factor">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="89" mass="9817" checksum="E354E54F7F351AAD" modified="2004-10-25" version="1">MQTVLIALLRFYKLAVSPLLGSRCRFYPSCSDYAREAIQYHGAARGTYLAARRLCRCHPFSAGGVDLVPPPNSDARNAPHEAEASSHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YW6</accession>
    <name>Q63YW6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaN</name>
        <name evidence="14" type="ordered locus">BPSL0074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196275.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106699.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0074"/>
    <dbReference type="EnsemblBacteria" id="CAH34057">
        <property type="protein sequence ID" value="CAH34057"/>
        <property type="gene ID" value="BPSL0074"/>
    </dbReference>
    <dbReference type="GeneID" id="56593630"/>
    <dbReference type="KEGG" id="bps:BPSL0074"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1661"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 10 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="11">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="12">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="13">
        <location>
            <begin position="247"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="367" mass="40679" checksum="E92C5C2A89BB2364" modified="2004-10-25" version="1">MQLVKTERDTLLRPLQTVSGIVERRHTLPILANLLITKNGPDVSFLSTDLELQITTRADFGVGGDQVATTVAARKLLDILRAMPDGQVTLSLADKRLTVQSGKSRFALQTLAADEFPTVAQSKDFGASLAVPQKAFRQLLGMVYFAMAQQDIRYYLNGMLLVVDGDRLMAVATDGHRLAFSSMKIEGSFGRQEVIVPRKTILELQRLLEDIDDTVKIDIAQTQAKFTFGQVELVSKLVEGKFPDFQRVIPKAHKNTFEIGREELQRSLQRAAILTSDKFKGVRCIIAPGQLKIMSTNADQEEAQEELEIAYQGDTVDIGFNVTYLLDVLANLKVDTVQVSLGDASSSALITVPENDEFKYVVMPMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HR8</accession>
    <name>Q63HR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112354.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2351"/>
    <dbReference type="EnsemblBacteria" id="CAH39838">
        <property type="protein sequence ID" value="CAH39838"/>
        <property type="gene ID" value="BPSS2351"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2351"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6817"/>
    <dbReference type="eggNOG" id="COG5527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRDDWRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000525">
        <property type="entry name" value="Initiator_Rep_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01051">
        <property type="entry name" value="Rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rep_3" evidence="1">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="480" mass="54031" checksum="2A911231B02B12FA" modified="2004-10-25" version="1">MPFWTHITTEAILPETSPPTRRMATKRAKKTDVDVVSASSAELRKAVEAIAIQPKNGKITLLTRKLFNVLLAVAQQADDSGDTYRALLSDIVANSAFDSNDTALVKEHLRRMVSVQVEWSTGTSSQKPGRKWGISTLIADAEILEDPATRRVWVEFSFAPKIKKKLLDPVQYARLSLQFQSQLRSSAGLALYEICVRYLTNPSHLTMREPWEWWRPILSGTPDTEAGDEAKREYKYFKRDYLRPAIAEVNAVTNIFVELVEHREGRRVAEIQFRVSERKQPMLALDEHPNVFDSTLVDRMVKIGIPLKEAQTLYADNEENRIRAALQLTEQRVRSTTLPPVRSAPALFKDALKKGYAPPVDTVEAPPLGGSAKLAAAAANVGQADDPKARLRSEYDAYRRKEAKQLYEEQGDAEREVARASFESDVLPALGSHLRDDWRRRGLDSKLVETAFFDWLAQRTWGEPTDGDLLAFTLSQSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I50</accession>
    <name>Q63I50_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205748.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112222.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2220"/>
    <dbReference type="EnsemblBacteria" id="CAH39705">
        <property type="protein sequence ID" value="CAH39705"/>
        <property type="gene ID" value="BPSS2220"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2220"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5809"/>
    <dbReference type="eggNOG" id="COG3546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IAHQKSF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="247" mass="26558" checksum="9CF5A7FD7361F7C5" modified="2004-10-25" version="1">MFFHNKRLQYTARVAETNPGLANLLLEQFGGPQGELAEAVDEQAQLYRKLNGGGNDSHVTQLLYGAGAPLVNSGAVPWTAAYVDTIGEPTADLRSNIAAEARAKIIYERLINVTDDPGIRDALGFLMTREVSHQKSFEKALYSITPNFPPGKLPAVPEYADLYYAMSDGGGARRKSPWNDGHDLRLVEHPPVPADGGDGKATIALDGDESTTLEAMRHRLKSDPSSDPTTGADLGSGGPDKPRDFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IB1</accession>
    <name>Q63IB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative outer membrane porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529379.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112161.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2160"/>
    <dbReference type="EnsemblBacteria" id="CAH39644">
        <property type="protein sequence ID" value="CAH39644"/>
        <property type="gene ID" value="BPSS2160"/>
    </dbReference>
    <dbReference type="GeneID" id="56531752"/>
    <dbReference type="KEGG" id="bps:BPSS2160"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5732"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KSRNWSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267218" evidence="4">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="5">
        <location>
            <begin position="11"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="359" mass="37795" checksum="FEB362AF60394130" modified="2004-10-25" version="1">MDKRLSALCGLGLASAGACAQTSVTLYGVADAYVEYATNQADAKGEPAALARMGSGGKSGSRWGIKGTEVLGGGWRAAFRLESGVNLNNGAGTGAGGFDRSAWVGLEHPRWGALRFGRQYTTMFDIMEHYSPTGAYSTLYEPDGAIVGISFRENNVVKYLATAGPLTFEAHYAFSNEPGAFQASAAHGAGFEYTGGALSFAFAYDDVHTPQAGGFAHLRRYAAAAMLTVEATQLIAGAAHGQGNVATPSVVTRYTFWWIGVRQAITPVVQLIGALYAERVRAQNPASPPAARHASGTPQQATLQLNYFVSKTTTLYAATGYARHAALDFDNYNYGFLHYSLAGARAGSAGVAVGVRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ID7</accession>
    <name>Q63ID7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112135.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2134"/>
    <dbReference type="EnsemblBacteria" id="CAH39617">
        <property type="protein sequence ID" value="CAH39617"/>
        <property type="gene ID" value="BPSS2134"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2134"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6537"/>
    <dbReference type="eggNOG" id="ENOG50316Q6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EQHNHRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="81" mass="8916" checksum="A059090BEB84BDE6" modified="2004-10-25" version="1">MTLLTEFDQADGRELRSLRLVATEDGKSVLLIEVDERKPGIHREVRYEITPAELIAAIRSHGAELPGETHGTVPLARTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IU1</accession>
    <name>Q63IU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188709.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111981.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1975"/>
    <dbReference type="EnsemblBacteria" id="CAH39453">
        <property type="protein sequence ID" value="CAH39453"/>
        <property type="gene ID" value="BPSS1975"/>
    </dbReference>
    <dbReference type="GeneID" id="56596829"/>
    <dbReference type="KEGG" id="bps:BPSS1975"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5477"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TKHPAYI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="427" mass="48046" checksum="86C33222B378C8E9" modified="2004-10-25" version="1">MQSTLDTVANAQERPPRSATPFSIGLAGIAAGLLTLWASRGAAALTGTERSLLACAAIIATIGAYELFVARVHLRPSAGLANRALRPLSVARVSLRLAALASVYAGIALVYWLLPEYHGAFYQPFWSLVGMLAPYVALAAPFYFGWMDRRMRDVDDAYLCWGRWLLRGQRPADWRPIREMLAGWAVKAFFLPLMIVYLSTDADHIGASFASAASAPFSLATFRFMYDLSYTMDLMFGALGYLCTFRLLDSHVRSTEPTTLGWLAALICYQPFWSLIGNNYIHYEGSMFWDNWLLSVPAIRFAWGVVIVALLLCYALSTISFGLRFSNLTNRGIITSGPYRFTKHPAYLAKNLSYWMISVPFVEPLGWRLAIMHSAALVAVNLLYWLRAKTEERHLMRDPDYRAYAEWIARHGMFARLGRMLGRERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J18</accession>
    <name>Q63J18_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dienoyl-CoA reductase [NADPH]</fullName>
            <ecNumber evidence="4">1.3.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fadH</name>
        <name evidence="4" type="ordered locus">BPSS1898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.34" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530263.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111904.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1898"/>
    <dbReference type="EnsemblBacteria" id="CAH39376">
        <property type="protein sequence ID" value="CAH39376"/>
        <property type="gene ID" value="BPSS1898"/>
    </dbReference>
    <dbReference type="GeneID" id="56529684"/>
    <dbReference type="KEGG" id="bps:BPSS1898"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5366"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWVHRAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="377"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="677" mass="73259" checksum="3DB560D7757C0B5C" modified="2004-10-25" version="1">MTTPFPHLLAPLDLGFTTLRNRVLMGSMHTGLEDSRKTLPRLADYFAERARGGVGLIVTGGFAPNVAGWTKPFGGTLSTGAAARRHRVIPDAVHAHGGKIALQILHTGRYGYHPFAVAPTRLKSPISPFTPHELSARGIERQIRAFVRCAQLAREAGYDGVEIMGSEGYLINQFISLHTNKRTDEWGGSYANRMRLPVEIVERTREAVGRDFIIVYRLSMLDLIPDGSNWDEVVLLAKAVERAGATIINTGIGWHEARVPTIATSVPRGAFAWVTKKMKGEVGIPLVTTNRINRPEIAEQILADGCADMVSMARPFLADAEFVKKAAEGRVDEINTCIGCNQACLDHAFKNQIASCLLNPRACHETELNYTRAASAKRVAVIGAGPAGLACATVLAQRGHRVELFDAAAEIGGQFNMAKRIPGKEEFHEALRYFARQIELAGVQLRLNRRVDAAELIAAGYDDVVLATGVAPRNPRIPGQDHPKVLTYIDVLARNKPVGERVAVIGAGGIGFDVSEFLVQDGESPALDLDAWKAEWGVTDPALARGGVVRGEVAPPARRITLLQRKATGLGKGLGKTTGWIHRATLKMKQVEMIGGVNYELIDDKGLHVTFGKERRDPTVIEADTIVLCAGQEPERALYEPLKAAGVPVHLIGGAELAAELDAKRAIDQGARLAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J57</accession>
    <name>Q63J57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004205409.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111865.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1861"/>
    <dbReference type="EnsemblBacteria" id="CAH39337">
        <property type="protein sequence ID" value="CAH39337"/>
        <property type="gene ID" value="BPSS1861"/>
    </dbReference>
    <dbReference type="GeneID" id="56598268"/>
    <dbReference type="KEGG" id="bps:BPSS1861"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5316"/>
    <dbReference type="eggNOG" id="COG2837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYYWCPP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="293" mass="32027" checksum="8DD13B0B55A8C6C8" modified="2004-10-25" version="1">MSDFQPGILAPIPAASRYLSFRISHPEHAASVLAALRDALDGVDTVIGLGPSLVQALDRKIDGLKEFPELSVPGAPVPSTPAALWVWLRADDLGAATVRSRDIERLVAPAFELDAAANAFRYADDRDLSGYEDGTENPEGDEALEVAFVSGKGAGLDGASFVAVQQWVHDFGKMREIPGDEMDRVIGRRKDDNEELEDAPAYAHVKRTEQESFKPEAKVLRRSSPWADERRAGLYFVAFGHSFRAFEVQMRRMIGATDGVHDGLFRFTQPITGSFFWCPPVKGGKLDLSALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JD6</accession>
    <name>Q63JD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ohr</name>
        <name evidence="2" type="ordered locus">BPSS1782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529046.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111786.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63JD6"/>
    <dbReference type="STRING" id="272560.BPSS1782"/>
    <dbReference type="EnsemblBacteria" id="CAH39258">
        <property type="protein sequence ID" value="CAH39258"/>
        <property type="gene ID" value="BPSS1782"/>
    </dbReference>
    <dbReference type="GeneID" id="56529802"/>
    <dbReference type="KEGG" id="bps:BPSS1782"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5222"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSACFDS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="139" mass="14397" checksum="33456C3EFE06F3A2" modified="2004-10-25" version="1">MNILYKTAATSTGGRDGRATSHDQKLDVKLSAPRELGGAGAEGTNPEQLFAAGYSACFLSAMKFVAGQNKQTLPADTTVTAEVGIGPNEEGGFALDVELRVALPGLDAAAAKTLVDRAHHVCPYSNATRNNVAVRLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JE2</accession>
    <name>Q63JE2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525133.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111780.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63JE2"/>
    <dbReference type="STRING" id="272560.BPSS1774"/>
    <dbReference type="EnsemblBacteria" id="CAH39249">
        <property type="protein sequence ID" value="CAH39249"/>
        <property type="gene ID" value="BPSS1774"/>
    </dbReference>
    <dbReference type="GeneID" id="56529810"/>
    <dbReference type="KEGG" id="bps:BPSS1774"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6091"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HPYTIAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="135"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="408" mass="43031" checksum="E8777542AFE46552" modified="2004-10-25" version="1">MISCKLKALESSKIRISEKSSRTYQGIQMKNFVAKIYIVALGSLIVTSSHSQQIRTHGAVTQITLPEHGSQASSIDFKNAIPIPLPKPIVAPPTMLDSLMYNAKPSLGVPGYSPGGAGDGKQRPMRLVAPMDLNQIGIEPQEFGSSNQPYTTSQVNAYGDNTQYYYPFRPAGKLFFNIGSASYLCSASLIKRGVVVTAAHCVANFGQRQFYSNWVFVPDYSNGSAPYGVWSAASATVMTSYYDGTDSCAVSGIVCQDDVAVILLAPQGGSYAGNSAGWYGYGWNGYGYNPSGLALIDQLGYPVALDSGVFMERNESQGYVSSGYSNNTIIGSLMTGGSSGGPWLVNLGMPPTLSGTTFGNSGAHNTVVGVTSWGFTDLAVKQQGASPFTSSNIVTLVNTVCSGTPAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JU0</accession>
    <name>Q63JU0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSS1624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the YscJ lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528902.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111632.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1624"/>
    <dbReference type="EnsemblBacteria" id="CAH39099">
        <property type="protein sequence ID" value="CAH39099"/>
        <property type="gene ID" value="BPSS1624"/>
    </dbReference>
    <dbReference type="GeneID" id="56529964"/>
    <dbReference type="KEGG" id="bps:BPSS1624"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5908"/>
    <dbReference type="eggNOG" id="COG4669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRIQQMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003282">
        <property type="entry name" value="T3SS_HrcJ/YscJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01338">
        <property type="entry name" value="TYPE3OMKPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02544">
        <property type="entry name" value="III_secr_YscJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="11">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="29603" checksum="7F3BEABCAC12CEBC" modified="2004-10-25" version="1">MIMKPLRLPISAAGARRAARLAALVACVALFAGCRQELYGGLAERDCNEMMAALLQNGVDAQKKTPDGGKTWTLAVDDKQIVKAMEVLRARGLPATRYDDLGALFKKDGLVSTPTEERVRFIYGVSQELSDTLSKIDGVVVARVHIVLPNNDPLAQVAKPSSASVFIKYRPNANLATLTPQIKNLVVHSVEGLTYDEVSVTSVAADPVDLVSAAQPAAQNSRGATLVGVLIALAVGGALAAAGGALWWRARKRGGGAGAHGIAARPRGGARDAKAAAPRQAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K29</accession>
    <name>Q63K29_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Surface presentation of antigens protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bsaW</name>
        <name evidence="9" type="ordered locus">BPSS1537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188067.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111543.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1537"/>
    <dbReference type="EnsemblBacteria" id="CAH39010">
        <property type="protein sequence ID" value="CAH39010"/>
        <property type="gene ID" value="BPSS1537"/>
    </dbReference>
    <dbReference type="GeneID" id="56597882"/>
    <dbReference type="KEGG" id="bps:BPSS1537"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4892"/>
    <dbReference type="eggNOG" id="COG4790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIVLVMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005773">
        <property type="entry name" value="YopR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01102">
        <property type="entry name" value="yscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="226" mass="24769" checksum="BE1080791824CB9E" modified="2004-10-25" version="1">MANNEIALIVLLTAATLVPFVVAAGSCFIKFSIVLVLVRNALGIQQVPSNLALNSIALIMSLFVMMPVAQSAYRYLQHHPLDVMSGASVNEFIDGGLGDYKRYLTRYSDPELVRFFERAQTARLKGDDADAADADDAPDGLDNSLFSLLPAYALTEIKSAFKIGFYLYLPFLVVDMVVSSVLLALGMMMMSPVTISVPIKLILFVAMDGWTLICKGLIEQYLNLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K38</accession>
    <name>Q63K38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205636.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111534.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1528"/>
    <dbReference type="EnsemblBacteria" id="CAH39001">
        <property type="protein sequence ID" value="CAH39001"/>
        <property type="gene ID" value="BPSS1528"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1528"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5784"/>
    <dbReference type="OMA" id="GWNDSIA"/>
    <dbReference type="PHI-base" id="PHI:4484"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="880" mass="87368" checksum="C1D43B9A3C19DA92" modified="2004-10-25" version="1">MPPSIHRTSSINSTPAVTAAGARRASGPGGVLSADVARVASARRHTMPEIGARRGVDGDRAAPAPRESFRRRLETVSSRAPTPPPEADSRAANARTTGAADGAGATGAAAGPSHGATSLDAARAYLAELAGDRGGALTTLVAQLNGHDRRALDHLALTVHALHLSVDDASHAKTFAGIGDALASFLAAAARANAKPGSTPRDLCVEGNKGYRKLCECVGALLRSDGIANALFGRARERGDAAADTLVSERLGGRMDGHVRTNGMVNRHGGDAQRRMADAAQRFALGARHATNLVDMVGTALELLGRTDQLLNDVSLKRPAAEPGGPRAPGGGRAAPAGPASGAAQQPAAPVVVNNHNENNVNVNLDGLERLVGDLGKMMGALLERMGAYDPSHTRPAAPDANGPAPVRTGGHTTVVKSPVSVARTSNNGAPGSPAADGTRGDAPMPPTTPALPATPATPTTPPAGGPSMDERTPATNTLERGAGNGGASPTGAWRRGDDGGWRMARGNPVVRTTEGATRIDPFSRVGARAASGAGAARAWRDAAADATQRSLASGTSGGAADAIAPRAGAGAAAGGDAARVARRMPDVRAGGLERDAPGERAAGPNGSNGSAVGQPIAGHAPAGGPDAADFSDASGTGGTGARAPGIPPATGSWSRDPASGRWLRAGGGVPLRSTEGFGRIDPFAGVQRNASATGASAVSSPSFASASMSVGSTGALPAGSSIASPDTSGIAPAVASGGALDVASNVASNVTSNVTSNVASGVTSGVTSGVAPDGTAWTRPSALAPRNIDPRRMNRAQLERAGLYPLVDDALPPSSQSAPADAGDAGDAAARRASRPDTGAPQPGAAKTFPSVAPAHRIVTTEGAARVGWNDSIANGTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM0</accession>
    <name>Q63KM0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536863.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111351.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1341"/>
    <dbReference type="EnsemblBacteria" id="CAH38812">
        <property type="protein sequence ID" value="CAH38812"/>
        <property type="gene ID" value="BPSS1341"/>
    </dbReference>
    <dbReference type="GeneID" id="56530239"/>
    <dbReference type="KEGG" id="bps:BPSS1341"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4642"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VQFYTHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="279"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="660" mass="68695" checksum="AC6780FC5CB5C33C" modified="2004-10-25" version="1">MSAAPVALPDAAPPAGLPDPATLARLASEFLAALPGQPAAPNAGAGSGAVGGVPSALPAAAPMLASVSNPAPPGSPLAGPGGTGTGVPGIGVPPGKVPGANLVPAPTHVLSLGNRTPALVGHAAAQNGWPDSAVAIAPALEPRAGGVALGVPPVPEPDAVRRAGDASAAAAPSPWSYYFVEPASDDWWRDAARTPIDVPRDGVASPRAFGLPDENAWRDLLSIGWPAADRHRASRYFVDDAQPTNAHAPGAGAHPPFDIAAIRRDFPILAERVNGKPLVWFDNAATTHKPQAVIDRLAHFYAHENSNIHRAAHALAARATDAYEHARATVQRFIGAASPDEIVFVRGATEAINLIAKTWGVGNVGEGDEIVVSHLEHHANIVPWQQLAASVGAALRVIPVDDAGQVLLGEYRKLLNDRTKIVSVTQVSNALGTVVPVKEIVELAHRAGAKVLVDGAQSISHMRVDVQALDADFFVFSGHKIYGPTGIGVVYGKRALLDGMPPWQGGGNMIADVTFERTVFQPPPNRFEAGTGNIADAVGLGAALDYVARIGIERIARYEHDLLAYAAGVLAPVPGVRLIGTARDKASVLSFVLKGYETEEVGRALNAAGIAVRSGHHCAQPILRRFGLEATVRASLAFYNTRDEVDAMVDVVRELAARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KR1</accession>
    <name>Q63KR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative protocatechuate 3,4-dioxygenase alpha chain</fullName>
            <ecNumber evidence="5">1.13.11.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pcaG</name>
        <name evidence="5" type="ordered locus">BPSS1301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.3" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524240.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111310.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1301"/>
    <dbReference type="EnsemblBacteria" id="CAH38771">
        <property type="protein sequence ID" value="CAH38771"/>
        <property type="gene ID" value="BPSS1301"/>
    </dbReference>
    <dbReference type="GeneID" id="56530280"/>
    <dbReference type="KEGG" id="bps:BPSS1301"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4589"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRFDIHL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012786">
        <property type="entry name" value="Protocat_dOase_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02423">
        <property type="entry name" value="protocat_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="197" mass="21399" checksum="48136D01A2BF6F81" modified="2004-10-25" version="1">MTTLKQTPSQTVGPYFAYGLCPQQYNYDLKSLFTAEIATPDAAGEPILLVGRVLDGDGHPVGDALLEFTHVDGDGRYPASRDEAAQRGFSGFARVGTGTHAQNRFVVRTVKPARTSDTDAPHIDVTVMMRGMLAHAFTRIYFDDEAAANAADTALASVPAVRRATLIATRDAQANGVTVYRFDIHMQGERETVFFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KT9</accession>
    <name>Q63KT9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184214.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111282.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1275"/>
    <dbReference type="EnsemblBacteria" id="CAH38742">
        <property type="protein sequence ID" value="CAH38742"/>
        <property type="gene ID" value="BPSS1275"/>
    </dbReference>
    <dbReference type="GeneID" id="56530308"/>
    <dbReference type="KEGG" id="bps:BPSS1275"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5471"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QATCVRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="174" mass="19406" checksum="EF9A17051E59EF0B" modified="2004-10-25" version="1">MEEAAFMTGADIASTLPPLLPRLLAFARRLCGDTHDADDLVQRACLRALERPHQLQRDTSPLNWMMAIVHSSWMSELRARHVRHRLQTDWNDDVIDALPGPTAADPQIHAMNAQIIRAVELLPETLRAAMLLIAVEGLSYQEAAGVLDVPIGTVMSRLWRARQSIGAQFGARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KU0</accession>
    <name>Q63KU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polyketide synthase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111281.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1274"/>
    <dbReference type="EnsemblBacteria" id="CAH38741">
        <property type="protein sequence ID" value="CAH38741"/>
        <property type="gene ID" value="BPSS1274"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1274"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5468"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVESNAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="610" mass="64619" checksum="2630C26B9B3D7792" modified="2004-10-25" version="1">MRRVQITDGAIVPSNFAEHFENQVLKYGNRSQFVFLHGKPGDSAGEARLGYAQLDARARSIAAWLSACGAARRPVLLVYPEGLAFVAAFLGCLYAGAIAVPVPVPADARSVERTRRIVRDAGIALALTPTAADAHALANCLAAPGDAVSTVGALRCEATDALEPLDASAWSRPALDASAIAFLQYTSGSTGEPKGVVVSHRNLLHNEAQIQRVVASDADSVVTGWLPHFHDMGLIGMLLHPLYVGCDCVFMAPSTFLRRPVRWLEAATHYAATITVAPNFAYDLCARAVKREQLGGLDLSALKVALNGAEPVRAKTIEAFSARFAPVGFDARAFSPCYGMAEVTLLASAGRPAAAPVLLDIDARALERHEASLAKPGAEALRVVGSGRAVDLDLRIVDPQTHAVAADGRIGEIWLRGDSVAQGYWRRPDASEAAFRARTAAGDGPYLRTGDLGFVRDGELFVTGRLKDLLIVNGRNLYPQDIEDFVRELHPALGAGAGAAFSIDADGERVVVVHEIKEARLDDGLSAAALSARIRTALARAFDIAAPSVVLVPRGGVKRTTSGKVQRGLTRDAFLAARLRVLHEDIQVPVRSLRVAAGEGVAQDASRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L72</accession>
    <name>Q63L72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111149.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1136"/>
    <dbReference type="EnsemblBacteria" id="CAH38604">
        <property type="protein sequence ID" value="CAH38604"/>
        <property type="gene ID" value="BPSS1136"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1136"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5294"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRGPIML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="37"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="287" mass="31292" checksum="F425BC36B54B2A48" modified="2004-10-25" version="1">MQSTFRGPIMLTLTSSHSAQALSRQPFDGTLPLSEVTLPIRTPRTMTDDEVSGMIETFNRYGFVILDCESSERDDLLALKTWLGNAAPHKRADADGVVPINAFEPVAGHIDSSHEAHLPHTDGAFSDTPERIITLQCVRPSRNGGLSTLSSAKAAYRHVVACYGDITPLTRANALTIERTTQKSTAAVFKEDDDGWSIKFRMNDGAATATPAPAAADMYGSLACFLTDPENMLLFPLEPGQILIGDNTAVTHGRTSYPPHQRRNMRRLNFDGRGALARELVFGFSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LA1</accession>
    <name>Q63LA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528319.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111120.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1107"/>
    <dbReference type="EnsemblBacteria" id="CAH38575">
        <property type="protein sequence ID" value="CAH38575"/>
        <property type="gene ID" value="BPSS1107"/>
    </dbReference>
    <dbReference type="GeneID" id="56530479"/>
    <dbReference type="KEGG" id="bps:BPSS1107"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4317"/>
    <dbReference type="eggNOG" id="COG3613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NAHKREN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="17056" checksum="885C56BEE9AB39BE" modified="2004-10-25" version="1">MKRMFLGGPFKSLVDKQTGVMPEGSINLFRRVIDHFEARGWDVHCAHRREHWGREFMTPDVCTKTDYEQISLCDYFVAFPGAPASPGTHIELGWASALGKPIVLLLEADKEYAYLVRGLDEITRIERVEFSGDRIDPVAIEAAIGRFDARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LA7</accession>
    <name>Q63LA7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528311.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111114.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1101"/>
    <dbReference type="EnsemblBacteria" id="CAH38569">
        <property type="protein sequence ID" value="CAH38569"/>
        <property type="gene ID" value="BPSS1101"/>
    </dbReference>
    <dbReference type="GeneID" id="56530485"/>
    <dbReference type="KEGG" id="bps:BPSS1101"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4309"/>
    <dbReference type="eggNOG" id="ENOG503310H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPVSYVC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266547" evidence="1">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="17431" checksum="D96250A5AB4293ED" modified="2004-10-25" version="1">MRNTVHRWMRVAATVATVAALGSTAAANETPEPATQNGIAYVTGGVGQDEVDALRAAASKYNLRMMFASRSGEYLSDVDVTIRAAAAQPVLTVRTRGPFLYARLPAGQYRIDARYGSAEQRRSVRVPARGGVHVEFRWAEPDRRGAMQLCDPRPCPRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LN2</accession>
    <name>Q63LN2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisQ</name>
        <name evidence="7" type="ordered locus">BPSS0981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198660.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110989.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0981"/>
    <dbReference type="EnsemblBacteria" id="CAH38443">
        <property type="protein sequence ID" value="CAH38443"/>
        <property type="gene ID" value="BPSS0981"/>
    </dbReference>
    <dbReference type="GeneID" id="56597347"/>
    <dbReference type="KEGG" id="bps:BPSS0981"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7301"/>
    <dbReference type="eggNOG" id="COG4215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMYLVIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030199">
        <property type="entry name" value="HisQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30133:SF1">
        <property type="entry name" value="PTHR30133:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="24582" checksum="31458B09C2A88003" modified="2004-10-25" version="1">MLFQGFGPLLWAGTIETVKLAVLSLAASLVLGLAGAAAKLSSNRALASVGTFYTTLIRAVPDLVLMLLLFYGIQILLNDVTDMLGAEQIDIDPFVAGIVTLGFIYGAYFTETFRGAFLAVPRGQLEAGFAYGMGAWRVFARIMFAQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKAAQDAGKSTLNFFFFTLAAGAIYLAITTLSNLVLMYLEKRYSAGVRRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LN6</accession>
    <name>Q63LN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative cytochrome c subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSS0977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="8">Binds 3 heme c groups covalently per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Binds 3 heme groups per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110985.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0977"/>
    <dbReference type="EnsemblBacteria" id="CAH38439">
        <property type="protein sequence ID" value="CAH38439"/>
        <property type="gene ID" value="BPSS0977"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0977"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5095"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHTPRGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014353">
        <property type="entry name" value="Membr-bd_ADH_cyt_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000018">
        <property type="entry name" value="Mb_ADH_cyt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="186"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="315"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000018-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000018-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH38439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="437" mass="46109" checksum="C4F496C16C772781" modified="2004-10-25" version="1">MPGLSSAADAAASGAPAPAASSVPAASAAPAAVRAADATLVERGRYLAVAGDCMACHTAKGGKPFAGGLPMRAPLLGTIYTTNITPDKETGIGDWSFADFERAVRHGVAKNGDNLYPAMPYVSYTKVTDDDVRALYAYFMHGVEPVRQPPRRNDIPWYLSMRWPLKIWNLLFLKEGVYQPKPERGVEWNRGAYLVQGLAHCGTCHTPRAVTLQEKSLDETGGSFLAGSVLSGWDGYNITSDPNAGIGGWSQPQLVQYLRTGSVPGLAQAAGPMAEAVEHSFSRMSDADIGAIATYVRTVPAVADGAAKARSAWGKPAEDGIRLRGVALASTGIDPARLYLGNCASCHQMQGKGTPDGYYPQLFHNSTVGAPNPTNLVQVILNGVARKAGGEDVGMPAFRHELSDAQIAALANYLTVQFGNPAAKVSEQDVAKLRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LP2</accession>
    <name>Q63LP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110979.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0971"/>
    <dbReference type="EnsemblBacteria" id="CAH38433">
        <property type="protein sequence ID" value="CAH38433"/>
        <property type="gene ID" value="BPSS0971"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0971"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5087"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QLWRAHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="119" mass="12030" checksum="D048DCB30B537A62" modified="2004-10-25" version="1">MHAPRACDARAQARADGEDAAGRAGGDSGCDPALVAVLLRLREAAVDARGAPWSLAKLAKRAGMPMSALRRALTRLDAAGVTETIVREDGTGCAALTAQGRQWCDALFGGGAAARGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LW2</accession>
    <name>Q63LW2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195450.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110909.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0900"/>
    <dbReference type="EnsemblBacteria" id="CAH38362">
        <property type="protein sequence ID" value="CAH38362"/>
        <property type="gene ID" value="BPSS0900"/>
    </dbReference>
    <dbReference type="GeneID" id="56597260"/>
    <dbReference type="KEGG" id="bps:BPSS0900"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7193"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWQMVQQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="83"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="31153" checksum="6A0D14DD930FB316" modified="2004-10-25" version="1">MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHVLMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPRPEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M21</accession>
    <name>Q63M21_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200941.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110850.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0839"/>
    <dbReference type="EnsemblBacteria" id="CAH38301">
        <property type="protein sequence ID" value="CAH38301"/>
        <property type="gene ID" value="BPSS0839"/>
    </dbReference>
    <dbReference type="GeneID" id="56597165"/>
    <dbReference type="KEGG" id="bps:BPSS0839"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7116"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYGHPRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="155"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="30426" checksum="7244C7B571EC29F0" modified="2004-10-25" version="1">MSYKSILVHLDTSDRARARLETALTLARQFGAYLSAVFAVYTPEPTSFYVMAGTADYFADQQRRRDEKRAALERLFHAELKRADVEGQWIVADARANEAVPHYARYADLVIAGQTDPDDPETYVDDSFPDTLVLSAGRPVLLLPYAGMPSAIGTRVLVAWDGSREATRAVHDAAPFLALATKTTIVTVNGAAHEPPGARIPGADIALTLARHHANIDVRDLERARDASIGDVLLSHAYESGTDLLVMGAYGHARWKELILGGVTRTIFASMTVPVLMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M68</accession>
    <name>Q63M68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200881.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110803.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0794"/>
    <dbReference type="EnsemblBacteria" id="CAH38254">
        <property type="protein sequence ID" value="CAH38254"/>
        <property type="gene ID" value="BPSS0794"/>
    </dbReference>
    <dbReference type="GeneID" id="56530754"/>
    <dbReference type="KEGG" id="bps:BPSS0794"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7047"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIWDSKV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="27487" checksum="2CD8974E6841936B" modified="2004-10-25" version="1">MNLNLNDKVVIVTGGGSGIGGAITLALAEEGAIPVVFGRSPLADAFAERLRALQSRARFVRVDLVDDARCREAVDETVAAFGRIDGLVNNAGINDGVGLDAGRDAFVASLESNLIHYYVIAHYCLPHLKASRGAIVNVSSKTAITGQGGTSGYCASKGAQLSLTREWAASLADDGVRVNAVIPAEVMTPLYANWLARFDDPDAKLQSITRKIPLGKRMTSAEEIAWTTVFLLSERASHTTGQWLFVDGGYTHLDRALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA1</accession>
    <name>Q63MA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205458.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110770.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0759"/>
    <dbReference type="EnsemblBacteria" id="CAH38219">
        <property type="protein sequence ID" value="CAH38219"/>
        <property type="gene ID" value="BPSS0759"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0759"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7001"/>
    <dbReference type="eggNOG" id="COG1457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTIYNFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="420" mass="44343" checksum="FA8B9D5C54557C95" modified="2004-10-25" version="1">MATRGEFSLSEVPAHERKGALSITMVLLSFTFFTGTMFAGGKIGVAFRVVDMLWVAVVGNLLLAAYAAALAFVASRSGLNSVLMGRFCFGEVGSKLSDFLLGFAELGWYAWGTATVAIVLVKLLGWPASVTTPLMVLFGFGFSITAIVGYRGMDALSRVSVPLMFALLVVSMWIATRDVGGWPGLAKIAPTQPMSFAAAVTMVFGTFASGATQATNWTRLAKSGRAAVAASMIGFFVGNGLMIVAGAYCAIVYQQSDIVEVMMLQGLSIAAVVMLCLNLWTIQGPTIYNVSAAACHLLRSERRRTLTLVGAAVGIVLAIGGMYEMLIPFLILIGSIIPPVGGVILADFWYRHRGRYPAIASARLPRFNIAGLAAYAIGAALAYASPWIAPLVGIAASSFCYIVFVQIAGRAVRAPSVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MD2</accession>
    <name>Q63MD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205454.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110739.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0726"/>
    <dbReference type="EnsemblBacteria" id="CAH38186">
        <property type="protein sequence ID" value="CAH38186"/>
        <property type="gene ID" value="BPSS0726"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0726"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6953"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIGFMVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="502" mass="54237" checksum="64B1B49D78FF862D" modified="2004-10-25" version="1">MDYGVLLSNFERDTARDALARASQQHRLYACLRAAILNGTLEAGTYLMSSRALAETLRIARNTVLYAYERLAAEGFVVARRQGTMVARVGLPAASATASPAHARPALARRVTGLPDIDADDEREPLPFLPGMPALDQFPLAPWRRAVERAWRRIGPAQLGHAPLGGNLRLRQAIAEYLRVSRGIGCDARQVFITDGTQHGLDLCARTLADAGDTVWIEHPGYAGARAAFEAADLRLVPIPVDADGLAPSAEHWRAHPPRLVYITPSHQYPLGAVMSVERRVALVANARAAGAWIVEDDYDSEFRHFGAPLAALQSLGDDAPVVYLGTFSKTMFPTLRIGFVVASAALAPQLRHTIGALAPRGRLAEQLALADFIEAGHFTRHLRRMRRLYEERRDALQDALARHLGGALTVSGGAGGMHLSARLDAPVADVDVARAALARAITVRPLSRFCLPGTDRAAYNGLVLGYGAVPTEQIDACVRRLGAAIDDALREVTRAPRDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MG8</accession>
    <name>Q63MG8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MipA/OmpV family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110703.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0689"/>
    <dbReference type="EnsemblBacteria" id="CAH38149">
        <property type="protein sequence ID" value="CAH38149"/>
        <property type="gene ID" value="BPSS0689"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0689"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4739"/>
    <dbReference type="eggNOG" id="COG3713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TDAQSMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010583">
        <property type="entry name" value="MipA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38776">
        <property type="entry name" value="PTHR38776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06629">
        <property type="entry name" value="MipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266590" evidence="5">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="27469" checksum="47B109F76172EA78" modified="2004-10-25" version="1">MRPSLHCLRYCMPFAGFVSITAAQAENVYTLSLGAGFAPRYAGSSQYRAVVAPSFSAEFDNGIFVGPLGGVGYRLKLPGQAFVAAAVSYDDGRADEDRFDRPGSNYLKGMGNVPGSVIAAVQAGVVLYGGSVLSVSVDTPVTHTSRGVSGHVDLAVPVFNAGRHEIVLTGSVHAASGRYTQTFYGVTDAQAAATRFAPYSTKGGIDSASMSVAWTYTFSKHWSVDTTLGLTRLVGRYGNSPIVQRKTQYFGLSALTYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ8</accession>
    <name>Q63MJ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family S15 non-peptidase homologue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0654"/>
    <dbReference type="ESTHER" id="burps-q63mj8">
        <property type="family name" value="Lactobacillus_peptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38113">
        <property type="protein sequence ID" value="CAH38113"/>
        <property type="gene ID" value="BPSS0654"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0654"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6854"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMEGVSY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="339"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="578" mass="63003" checksum="9A585DDAA019B4DD" modified="2004-10-25" version="1">MAEVGAQFERSPTGLPYPKLATLYPGHDGPIVDNGMILPWLSMRPPLKSNVMVQTPFDTDQDGKLDRIALRIVQPAEVAEGLKTPVIVRPSVYYADPTYATQTRAPFLGEAEYLRMGYTIVYADSIGTNQSDGCWSVMDRTEREAMASVVRWLTNDPGAPGFDAQGKQVAASWSTGHVAMEGISYGGTLPTMVAATGVPGLEAIVPVEGISSGYDYFRYNGVIADIDNTVSLGSYMKSQQAFARSSICEPARVAAVTASDDATYAYNDFWKVRNTVSLVDRIQAATLIAQGQADNNVKTKNATQLYDALYRAKKPVQLWLHSRNHDDPAWQKEWQKQIAMWYSRYLFGVNNGVETQPTYVRETPTGDIPVGATLPPDPNDTSDTLIGHCHSGHNPRDCIPTGELFIKEDAWPKTVDTFYHLRGDGRVGGLLTPSPADGTQAASVDLSNATAVTYETKSLANVTRYAGAIRVAMRGRFAPAVSNIKATLSVDGHDVTYGWANPRFYKGLDVAQLIVPNTDYDFTLEMMPRDFTVLPGSKVMLKLEGYQGTSLVTLDLSHTVLAMPVVPKAHVAAVMVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS9</accession>
    <name>Q63MS9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110590.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0569"/>
    <dbReference type="EnsemblBacteria" id="CAH38026">
        <property type="protein sequence ID" value="CAH38026"/>
        <property type="gene ID" value="BPSS0569"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0569"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4589"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWVDYNG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17727" checksum="CFAE0ECE5E728E53" modified="2004-10-25" version="1">MQATELTIHRDTVRAEWVDYNGHLRDAFYLLIFSFATDALLDAIGLDDAARRARGRSVYTLEAHVNYLREIKEGTRVRVDARVLAHDAKRLHLYLEMFAAGIDGAVSASEQMLLHVDTGGPKAAPFDADVAERIANLHALQRAHPAPAYAGRVIGLPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N19</accession>
    <name>Q63N19_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525507.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110500.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37934">
        <property type="protein sequence ID" value="CAH37934"/>
        <property type="gene ID" value="BPSS0478"/>
    </dbReference>
    <dbReference type="GeneID" id="56531072"/>
    <dbReference type="KEGG" id="bps:BPSS0478"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6627"/>
    <dbReference type="eggNOG" id="COG4125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ILVPCYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007896">
        <property type="entry name" value="BTP_bacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05232">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="BTP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="BTP" evidence="2">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="16123" checksum="8BCF21649395178A" modified="2004-10-25" version="1">MQGFKRKIVYVACFELIAIAITTTGFALLTGQAPAHASIAAVASSAIAVVWNLVYNTAFEWWEARQSRRGRGLLRRIAHAAGFEAGLVVMLVPLFAWWLDVSLWQAFVLDLGLIAFFLAYTFAFNLAFDRVFGLPASAQPAPSEASPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N79</accession>
    <name>Q63N79_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS0416A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110440.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0416A"/>
    <dbReference type="EnsemblBacteria" id="CAH37872">
        <property type="protein sequence ID" value="CAH37872"/>
        <property type="gene ID" value="BPSS0416A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0416A"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266179" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="118" mass="10936" checksum="C28A50A5779A5603" modified="2004-10-25" version="1">MPVVPVLPLLPLPPELAATPIPTAAATPAPTAATVPTLTPPNVAAPPAPAVPAVPVAPVASPAPVVPVVPAEPGMSVAPGVPGVPGVPGAPEPSFRMAPDARSAGCSPAAGVAAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ND2</accession>
    <name>Q63ND2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative bipolymer transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525409.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110387.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0367"/>
    <dbReference type="EnsemblBacteria" id="CAH37815">
        <property type="protein sequence ID" value="CAH37815"/>
        <property type="gene ID" value="BPSS0367"/>
    </dbReference>
    <dbReference type="GeneID" id="56531166"/>
    <dbReference type="KEGG" id="bps:BPSS0367"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6492"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRFAHDL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="104"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="26359" checksum="843BD4FE78DD3596" modified="2004-10-25" version="1">MQSYGIAHVWAQGDFVTRFIAIALLVMSILSWMVIVIKGWNVIRLKRLSKDAEQSFWHSDDFDEGVDKLGRASSSSQDNPFLALALSGKEAADHHHQTQPHLHDRMDVSDWVTRCLKDTMDEGIARMQGGLAILASIGSTAPFVGLFGTVWGIYHALLVIGATGQTSIDQVAGPVGESLIMTAFGLFVAIPAVLGYNALTRANKSVVSRLRRFAHGLHAYFVTGTRLASSQRDGLRLAARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NJ8</accession>
    <name>Q63NJ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188543.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110321.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0301"/>
    <dbReference type="EnsemblBacteria" id="CAH37749">
        <property type="protein sequence ID" value="CAH37749"/>
        <property type="gene ID" value="BPSS0301"/>
    </dbReference>
    <dbReference type="GeneID" id="56597810"/>
    <dbReference type="KEGG" id="bps:BPSS0301"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6407"/>
    <dbReference type="eggNOG" id="ENOG5033M6F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDYAAWE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="143" mass="15837" checksum="F367ED09508E8C43" modified="2004-10-25" version="1">MKLVLFLHLIFVAAWMSCVIVEGIFEHAIDRSPEQRAFISKLHWTTDKYVEIPAFTIVLITGAVLLMHRAPTPLLLTKVAFGTLAIALNAVCVWIVIRRMRYAAQADHAAWERIDRLQHKLGGVVAISMLVALGIGGYLFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NN5</accession>
    <name>Q63NN5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative porin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523466.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110284.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0265"/>
    <dbReference type="EnsemblBacteria" id="CAH37711">
        <property type="protein sequence ID" value="CAH37711"/>
        <property type="gene ID" value="BPSS0265"/>
    </dbReference>
    <dbReference type="GeneID" id="56531280"/>
    <dbReference type="KEGG" id="bps:BPSS0265"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6352"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWNQGNL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267398" evidence="7">
        <location>
            <begin position="21"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="7"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="382" mass="40082" checksum="1DF4C19702E2548C" modified="2004-10-25" version="1">MNKKLLTTAILAATASAAHAQSSVTLYGLIDAGVSYVNHSKSASGSDKLFKYDDGIAQGSRWGLRGAEDLGGGLKAIFVLENGFNSGNGTIGQGGAIFGRQAYVGLSHKDAGTLTFGRQYSFTTDILGANYSTGGNTVAGNYAYHVNDIDQLTSSRINNAVKFQSANYAGFTFGALYGFSNSTSFAGAPATTTGTTTTPGSSRAYSFGLNYANGPIGLGAAYTDIRYPSQATPAFTTNIANLTISNVRDLRSFGVGGRYIWGPATLWALWTNTRLEPVTGGSTTYNAYEAGGKYAFTTALSAGVGYTYSRVSGANSGHWNQVNGALDYALSKRTDVYLLAIYQEASGKNLQAQIGSSTSYFNTSGTGSKNQFAARVGIRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NQ0</accession>
    <name>Q63NQ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110269.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0250"/>
    <dbReference type="EnsemblBacteria" id="CAH37696">
        <property type="protein sequence ID" value="CAH37696"/>
        <property type="gene ID" value="BPSS0250"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0250"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4216"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LKREWRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="29903" checksum="BFB1623DB94E0382" modified="2004-10-25" version="1">MASKERDVQRSFLERSLLRRFGAAPAGGLLALFFVLPLAALVSAAFAEGGRAFAAVLHDPLVGDAIGRSLALAVGTGTLSTCVGVPLALSFAEQPPARRRWLLALLGVPLAFSGLVIAYGFILTFGRAGFVTTLLAGLGADAAKVGGVIYTTFGLVVAYAYYLIPRVALMLFPAFANLERRPLEAAMSLGAKPWRAWLDVAWRELWPSVMAAWCLVTAIALGTYGTALALAGTQINILPLLMYLKLSDGQTDFSQAAVLSIVLTALCTCVLAMGEYVGRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NX2</accession>
    <name>Q63NX2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205359.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110197.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0176"/>
    <dbReference type="EnsemblBacteria" id="CAH37621">
        <property type="protein sequence ID" value="CAH37621"/>
        <property type="gene ID" value="BPSS0176"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0176"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6238"/>
    <dbReference type="eggNOG" id="COG4455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRYYWIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009211">
        <property type="entry name" value="TagJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07024">
        <property type="entry name" value="ImpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029288">
        <property type="entry name" value="SciE_ImpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="321" mass="33857" checksum="1776E7E09B333A2D" modified="2004-10-25" version="1">MTTPAFPAPPGARTSARPHDTLLDARLAAAQAAVRARPVDAASRWALFQLLCVTGQWERAVGQLQAYARFAAQHAHIAHAYRDLIRAERFRARVMAGQARPGFVFDAPPWIDDLLEALRAQAAGARDEADRARSRALDRAPFVAGRGPDAPFDWIADSDSRFGPVCEVVTAGHDRWLPFSDLAGWRLARPGVLLALVWAPCVLTLADGSVAHGFMPARYPGSELADGGGAPGASAAAHEADAHESAAREADALRLGSRTAWRDVGRTGVFALGRKTWSTSAGDAGLFELHACEFGARARAGAVLGGAAREARGGEAADGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P30</accession>
    <name>Q63P30_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531568.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110139.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37563">
        <property type="protein sequence ID" value="CAH37563"/>
        <property type="gene ID" value="BPSS0118"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0118"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9608" checksum="039CA0D14C7274F4" modified="2004-10-25" version="1">MAFVYSIARPEPASFEHSSYGILAVTYDCGALQVRQGISAFGVAGVQQYARCNDLFPFHPCFATRGRREEYEVVEKHQELPPLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PB8</accession>
    <name>Q63PB8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551133.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110051.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0027"/>
    <dbReference type="EnsemblBacteria" id="CAH37470">
        <property type="protein sequence ID" value="CAH37470"/>
        <property type="gene ID" value="BPSS0027"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0027"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6026"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QTANTEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="193"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="647" mass="71764" checksum="13882FB27E340977" modified="2004-10-25" version="1">MKLLLVDNLVMPEEGSLAYLDVHPHLGLLALAAVAEADGHRVRIYDPKRLIRDGTLAYDATLYERASRAILAERPDAVGFTALGCSFLFALNVAALLKRREPDLPVLLGGPHATMLHRQILERFPQFDIIVRYEADEILPAVLDCLEQRTFDVIPGLSWRATGHGAPLRFTDGKPKVEELDRLPIASYDHYPVDDLGLSMLRIEAGRGCPFACTFCSTAGFFQRSFRLKSAERLVHELDILHRRYRVSDFKLDHDMFTVNRHKVMAFCEAVAGRGYRWRASARIDCVDEALLRKMADAGCVNLYFGVETGSERMQTICRKRLDLRLVEPILAAADSFGIETTASFITGYPQECGQDQDDTLDMIGRCARRPSCLTQLHMLAPEPGTPLFDEHGAQIAYDGYGGPYNTRLLGPGDEREVLDHPDIFQTYYYYPAALPRARHIFAVEAVDVLRRAGPIILAYALREFGGRLSRLISAWRRFADETSPGALPDAAGLEAFVAARFGRGHHLHSLFRYALRLSAARAPADVVAEGPYEPDRPCMLAENVGLLEDIHNCEALVDRLRRSNDGAPALGDADVGGLGAYIVRADGEAVTGYWVESGIAAILDLFRAPRSCRAAAQWLAHVTRNDGVDASIFEPLLRRGILVPAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI5</accession>
    <name>DCUP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="1">UPD</shortName>
            <shortName evidence="1">URO-D</shortName>
            <ecNumber evidence="1">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemE</name>
        <name type="ordered locus">BPSL3391</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524502.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109984.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PI5"/>
    <dbReference type="SMR" id="Q63PI5"/>
    <dbReference type="STRING" id="272560.BPSL3391"/>
    <dbReference type="EnsemblBacteria" id="CAH37403">
        <property type="protein sequence ID" value="CAH37403"/>
        <property type="gene ID" value="BPSL3391"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3391"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1800"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000023884" description="Uroporphyrinogen decarboxylase">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="28"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <sequence length="364" mass="39472" checksum="3FE2CB59815FADED" modified="2004-10-25" version="1">MAQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYVRRVLAQLKREHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PK8</accession>
    <name>Q63PK8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase isozyme II large subunit</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ilvG</name>
        <name evidence="6" type="ordered locus">BPSL3366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205307.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109961.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3366"/>
    <dbReference type="EnsemblBacteria" id="CAH37379">
        <property type="protein sequence ID" value="CAH37379"/>
        <property type="gene ID" value="BPSL3366"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3366"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1833"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWVHRFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="202"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="395"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="567" mass="61217" checksum="B4369EBA17D88373" modified="2004-10-25" version="1">MSISPDREQRATTGARLLVDALLANHVERVFCVPGESFLAVLDSLADETERIRTIVCRHEAAAANMAEAVGKLTGRPGIAFATRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDREAFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMSGRPGPVVLALPEDVLSEPCAAQPVAPAARRVAAAPSAAQMSELRERLARAQRPLVLAGGSGWTPGACADLRTFVERWQLPIACAFRYQDTFDNAHPQYAGDVGLGVNPELARRIREADLLFALGPRLGEATTGGYTLIDIPRPKQVLIHVHQGADELGRVYAADLPIASGMPEIAAQLAALEPPASLAWAGSAAHAHRAYLDWQAPRPMPGEVQLGDVMRQLRERLPHDAIVTNGAGNYAAWLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGTIRMHQERHYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIEIRVPQDACTPAATLEQVREQGLRARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PQ2</accession>
    <name>Q63PQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524413.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109917.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3321"/>
    <dbReference type="EnsemblBacteria" id="CAH37334">
        <property type="protein sequence ID" value="CAH37334"/>
        <property type="gene ID" value="BPSL3321"/>
    </dbReference>
    <dbReference type="GeneID" id="56527826"/>
    <dbReference type="KEGG" id="bps:BPSL3321"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3775"/>
    <dbReference type="eggNOG" id="ENOG503178E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASNERIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008622">
        <property type="entry name" value="FliT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05400">
        <property type="entry name" value="FliT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="104" mass="11531" checksum="6606DDBAC183C287" modified="2004-10-25" version="1">MEKPEMDQMSLIEHVLSITREIDHAVQMADWTEAARLTEERSPYLMSITAEQTPASLALVRQLQAIDTALLANAKAAQAELQVEYRTAMDRLSQAGAYQAAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY1</accession>
    <name>Q63PY1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">BPSL3243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197905.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109837.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3243"/>
    <dbReference type="EnsemblBacteria" id="CAH37254">
        <property type="protein sequence ID" value="CAH37254"/>
        <property type="gene ID" value="BPSL3243"/>
    </dbReference>
    <dbReference type="GeneID" id="56594586"/>
    <dbReference type="KEGG" id="bps:BPSL3243"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1992"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ENPFTWA"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="64"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="228" mass="25465" checksum="7806C94C811C3A2C" modified="2004-10-25" version="1">MTGFDRQTISDTTAKMLLEVQAVHFNADKPFIFTSGWASPVYIDCRKLISFPRVRRGLMEMAEATILRDVGFEQIDAVAGGETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGYLEEGSRVLLVEDLTTDSRSKINFVNALRTAGAKVNHCFVLFHYDIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATGAQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q46</accession>
    <name>MSRP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-methionine-sulfoxide reductase catalytic subunit MsrP</fullName>
            <ecNumber evidence="1">1.8.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrP</name>
        <name type="ordered locus">BPSL3178</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:51292"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:51296"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="1">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <text evidence="1">Is attached to the inner membrane when interacting with the MsrQ subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrP family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527906.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109772.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q46"/>
    <dbReference type="SMR" id="Q63Q46"/>
    <dbReference type="STRING" id="272560.BPSL3178"/>
    <dbReference type="EnsemblBacteria" id="CAH37189">
        <property type="protein sequence ID" value="CAH37189"/>
        <property type="gene ID" value="BPSL3178"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3178"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2060"/>
    <dbReference type="eggNOG" id="COG2041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPYTEGL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016672">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01206">
        <property type="entry name" value="MsrP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022867">
        <property type="entry name" value="MsrP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0500">Molybdenum</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" description="Tat-type signal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000070679" description="Protein-methionine-sulfoxide reductase catalytic subunit MsrP" evidence="1">
        <location>
            <begin position="58"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01206"/>
        </source>
    </evidence>
    <sequence length="331" mass="37091" checksum="E4ACC0647DACB26D" modified="2004-10-25" version="1" precursor="true">MLIKKTLRAALAGDDIPRSEITPRAVFEHRRRILQAAGAAAAGGLVGAHGLALAAYASPDAAARKLAAPANPKFVVPEKVTSFKDITTYNNFYEFGTDKSDPARRAGTLRPHPWRVSVEGEVRNPKVYDIDALLKLAPLEERVYRLRCVEGWSMVIPWIGFPLAELIKRVEPTANAKYVQFVTLADPSQMPGLSAPILDWPYSEGLRMDEAMNPLTLLTIGVYGQVLPNQNGAPVRVIVPWKYGFKSAKSIVKIRFVDRQPPTSWNTYAPNEYGFYSNVNPNVDHPRWSQATERRIGEDGFFTPKRKTLMFNGYGDWVASMYRGMDLKKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QP6</accession>
    <name>Q63QP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194143.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109572.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2978"/>
    <dbReference type="ESTHER" id="burma-q62gx9">
        <property type="family name" value="abh_upf00227"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A40"/>
    <dbReference type="EnsemblBacteria" id="CAH36988">
        <property type="protein sequence ID" value="CAH36988"/>
        <property type="gene ID" value="BPSL2978"/>
    </dbReference>
    <dbReference type="GeneID" id="56594227"/>
    <dbReference type="KEGG" id="bps:BPSL2978"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2295"/>
    <dbReference type="eggNOG" id="COG3150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLAHYPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008886">
        <property type="entry name" value="UPF0227/Esterase_YqiA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35602">
        <property type="entry name" value="PTHR35602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05728">
        <property type="entry name" value="UPF0227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="189" mass="20774" checksum="F85D97114F8AE892" modified="2004-10-25" version="1">MILYLHGFRSSPQSFKARALAARLDELGRADEWRCPVLSVAPLAAIAAAEAEVAGVPAQRVTVIGSSLGGYYATWLAEKHGWRAVLLNPATQPQRDLRRHLGEQPLWHGGGTIVVEPHHLDELNALHVAAISRPERYYLFAATGDEVLDYREMLARYPGARTRVIEGSDHGISEFADYIDDVLAFCDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC0</accession>
    <name>Q63RC0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186322.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109348.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2752"/>
    <dbReference type="EnsemblBacteria" id="CAH36760">
        <property type="protein sequence ID" value="CAH36760"/>
        <property type="gene ID" value="BPSL2752"/>
    </dbReference>
    <dbReference type="GeneID" id="56594922"/>
    <dbReference type="KEGG" id="bps:BPSL2752"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2564"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IPSYREH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031982">
        <property type="entry name" value="PilE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16732">
        <property type="entry name" value="ComP_DUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="15806" checksum="4F2AA705A2DACAFE" modified="2004-10-25" version="1">MPCTGRNSPSRGFTLIEVVVAIAIVAVLAAFAVPSYRSYVERVNRLTAVAALYRAAQYVDAFGDAPPTALPEGVNRAPESGKLVYVLRIMFDDARGGYALEARPAADGAMRDDRCGVYVLHADGTRENRVAGGVALDGGAAEGDACWRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC9</accession>
    <name>Q63RC9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185661.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109339.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2743"/>
    <dbReference type="EnsemblBacteria" id="CAH36751">
        <property type="protein sequence ID" value="CAH36751"/>
        <property type="gene ID" value="BPSL2743"/>
    </dbReference>
    <dbReference type="GeneID" id="56594932"/>
    <dbReference type="KEGG" id="bps:BPSL2743"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2577"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDWMRGT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="35"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="318" mass="35144" checksum="7EF14966ADE18556" modified="2004-10-25" version="1">MAGDKKFASQADLAEKKVTFERLSEHAYAYTAEGDPNTGIIVGDDAVLVADTQATPVMAEDVIRRIREVTDKPIKYVLLTHYHAVRVLGASAYGADHVIASQDTYDLIVERGAADMKSEIERFPRLFRSVESVPGLTWPTLTFKGEMTLWLGKLEVKIMQLGRGHTKGDTVVWLPQEKVLLSGDLVEYGATPYAGDAYFQDWPATLDAIAALEPEKLVPGRGAALKTPREVADGLAGTRAFVSELYAKVKAGAAAGRDLNAIYKETYAALKPTFGDWVIFDHCMPFDVTRAFDEATQYPDPRIWTAERDKDMWHTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RG1</accession>
    <name>Q63RG1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE-family membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535750.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109307.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36719">
        <property type="protein sequence ID" value="CAH36719"/>
        <property type="gene ID" value="BPSL2711"/>
    </dbReference>
    <dbReference type="GeneID" id="56528486"/>
    <dbReference type="KEGG" id="bps:BPSL2711"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2621"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FQICIVA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="21567" checksum="B265238AD4FDF2F1" modified="2004-10-25" version="1">MTVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIGAVVVLDTSPWLYHALRIAGGGYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEASNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLFSLADLTCIALAHPLRKRAAPGGAAMIIGRYLAGGLFIALGVAAIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RH7</accession>
    <name>Q63RH7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rubA</name>
        <name evidence="9" type="ordered locus">BPSL2695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186709.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109291.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2695"/>
    <dbReference type="EnsemblBacteria" id="CAH36703">
        <property type="protein sequence ID" value="CAH36703"/>
        <property type="gene ID" value="BPSL2695"/>
    </dbReference>
    <dbReference type="GeneID" id="60548590"/>
    <dbReference type="GeneID" id="62010244"/>
    <dbReference type="GeneID" id="67433594"/>
    <dbReference type="KEGG" id="bps:BPSL2695"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2647"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APKDMFE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="56" mass="6527" checksum="1E21D5F8CD6AE9D0" modified="2004-10-25" version="1">MEYKSWMCLICGWIYDEEAGLPEEGIAPGTRWEDVPINWTCPECGARKEDFEMVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RK3</accession>
    <name>Q63RK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109265.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2669"/>
    <dbReference type="EnsemblBacteria" id="CAH36677">
        <property type="protein sequence ID" value="CAH36677"/>
        <property type="gene ID" value="BPSL2669"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2669"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3042"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SYYREGI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="385" mass="42948" checksum="75A63B616A16221F" modified="2004-10-25" version="1">MIFFQSDMSSASAPRIVLVCNTAWAIYTYRQGLLRMLIARGAQVTVLAPRDRTVEPLVRMGCRYAELPVASKGTSPREDLRTLIALYRHYRAIRPDLVFHYTIKPNIYGSIAAWLARVPSIAVTTGLGYVFIQQSHAARVAKQLYRFALRFPREVWFLNRDDLHTFTHEQLLAHPARARLLHGEGVDLEQFALAPLPARDTFTFVLIGRLLWDKGVREYVDAARMLRARYPHARFALLGPVGVDNPSAISQADVDAWVREGVIDYLGEAHDVRPHIARADCVVLPSYREGVPRTLMEASAMGRPIVATDVPGCRDVVADGSTGLLCAARDSASLAAQLARMLDMSAAERRAMGERGRRKIVAEFDEAKVVERYHQTISALTGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RK6</accession>
    <name>Q63RK6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoglucomutase</fullName>
            <ecNumber evidence="10">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pgm</name>
        <name evidence="10" type="ordered locus">BPSL2666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109262.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2666"/>
    <dbReference type="EnsemblBacteria" id="CAH36674">
        <property type="protein sequence ID" value="CAH36674"/>
        <property type="gene ID" value="BPSL2666"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2666"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2678"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KCSQVMY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="7">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="8">
        <location>
            <begin position="159"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="9">
        <location>
            <begin position="261"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="6">
        <location>
            <begin position="376"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="464" mass="50084" checksum="E02D082D4436AD0B" modified="2004-10-25" version="1">MISQSIFKAYDIRGVIGKTLDADVARSIGRAFGSEVRAQGGDAVVVARDGRLSGPELVGALADGLRAAGVDVVDVGMVPTPVGYFAASVPLALSGGERRVDSCIVVTGSHNPPDYNGFKMVLRGAAIYGDQIQGLYKRIVDARFETGNGSYERYDVADQYVERIVGDIRLARPLKLVVDAGNGVAGPLATRLFKALGCELVELFTDIDGNFPNHHPDPAHPENLQDVIAKLKTTDAEIGFAFDGDGDRLGVVTKDGQIIYPDRQLMLFAEEVLSRNPGAQIIYDVKCTRNLAQWVREKGGEPLMWKTGHSLVKAKLRETGAPLAGEMSGHVFFKDRWYGFDDGLYTGARLLEILARAADPSALLNGLPNAVSTPELQLKLDEGENVKLIDKLRADAKFDGADEVVTIDGLRVEYPDGFGLARSSNTTPVVVLRFEASSDAALARIQDDFRRALKAAKPDANLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR8</accession>
    <name>Q63RR8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Outer-membrane lipoprotein carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lolA</name>
        <name evidence="8" type="ordered locus">BPSL2603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the LolA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185701.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109199.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2603"/>
    <dbReference type="EnsemblBacteria" id="CAH36611">
        <property type="protein sequence ID" value="CAH36611"/>
        <property type="gene ID" value="BPSL2603"/>
    </dbReference>
    <dbReference type="GeneID" id="56594873"/>
    <dbReference type="KEGG" id="bps:BPSL2603"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2753"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YDPFVEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044874">
        <property type="term" value="P:lipoprotein localization to outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00240">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018323">
        <property type="entry name" value="OM_lipoprot_carrier_LolA_Pbac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 7" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019277" description="Outer-membrane lipoprotein carrier protein" evidence="7">
        <location>
            <begin position="45"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="238" mass="25381" checksum="AE0FC4D26C979DA7" modified="2004-10-25" version="1" precursor="true">MQHQSLAVHTGSGSGFAPKHGFARALRAALAGAACALVASHAFASGTEQLKAFVAKVHAAKGEFTQQIVKAPPKAASGAVPTVKPTDNSSGSFVFSRPGKFIWTYQKPYQQVLQADGDKLYVYDKDLNQVTERKLAGALGASPAAILFGSNDLDKNYTLRDAGEKGGIDWLEMVPKAQDTQFQRIGIGFRNGMLAAMELHDVFGNVTLLTFTNIQTNPPLKADQFKFVVPKGADVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S48</accession>
    <name>Q63S48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL2474B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109069.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36480">
        <property type="protein sequence ID" value="CAH36480"/>
        <property type="gene ID" value="BPSL2474B"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2474B"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2822"/>
    <dbReference type="OMA" id="PRRAGNM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="425" mass="44086" checksum="D8073DC8394D550F" modified="2004-10-25" version="1">MTHPANAPLQHANATRRGDEMTALPDASHPSSRVAWPAVEPGFAAASVRAMPIDAAARGIARLCRAVARAVRQCVARIGRARDDCEDCEDSDAHDDRHDRGSLDARSEPAPMPRMTTRAATRASASRPTESKRSRLAIRRDRRRASQTAASIDRIASANPSGSSPAPRRAGNMDLQRRSVTILALRAEAGAASDSELSEAAPKHGSLGQPAGGHDMRRALRHGDALAHLIGIVQVVQIAGAVRATANVLVLRPPAGTLFESGIHACPGALQRPLAEAVKLAPAICSTFAAARRRVAGGATHARWRTAAPRVPVRADRADDATAGVDARRMPATPGRAYCPSGRCGSRRAARASAIAKASASASGRRGSGDARDVGGPAASRIAANLLHARPASAGRVTAGAIGIIETKAAGNAGSRQDNHSPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S49</accession>
    <name>Q63S49_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BPSL2474A</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109068.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36479">
        <property type="protein sequence ID" value="CAH36479"/>
        <property type="gene ID" value="BPSL2474A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2474A"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2911"/>
    <dbReference type="eggNOG" id="ENOG5032Q0K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYSQGPV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266283" evidence="2">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="122" mass="13200" checksum="F9AAFBA69B49D622" modified="2004-10-25" version="1">MRIAACLARRRHSIAAALAASLAIACPYVTAAHENETYRIVDTRPEHVAARGRAERCARVDDGAFARQRDHAPMPVPVATPRPLVDGTAVTLWDEIGPPAPMPVPTDARHTVRGDGANYTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S66</accession>
    <name>Q63S66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-ketogluconate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011203830.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109051.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2459"/>
    <dbReference type="EnsemblBacteria" id="CAH36462">
        <property type="protein sequence ID" value="CAH36462"/>
        <property type="gene ID" value="BPSL2459"/>
    </dbReference>
    <dbReference type="GeneID" id="56596374"/>
    <dbReference type="KEGG" id="bps:BPSL2459"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2931"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="4"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="107"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="329" mass="34948" checksum="6EDF55A7E3F8FD3E" modified="2004-10-25" version="1">MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDASVLAAAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQALARRARGFGMRVIYHNRSRVAPEIEAALNAEYVPKAALLAQADHVVLVLPYSAQSHHTIGAAELALMKPSATLTNIARGGIVDDAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANLAADNLIAALGAGPRAGRPPNPINPGVLGKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S90</accession>
    <name>Q63S90_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sigma E factor negative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524614.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109027.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2435"/>
    <dbReference type="EnsemblBacteria" id="CAH36438">
        <property type="protein sequence ID" value="CAH36438"/>
        <property type="gene ID" value="BPSL2435"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2435"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2955"/>
    <dbReference type="eggNOG" id="COG3073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVVVPQL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16328">
        <property type="entry name" value="RseA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005572">
        <property type="entry name" value="Anti-sigma_E_RseA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036147">
        <property type="entry name" value="Anti-sigma_E_RseA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03872">
        <property type="entry name" value="RseA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89069">
        <property type="entry name" value="SSF89069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RseA_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="200" mass="20971" checksum="B667F65072CEC0DB" modified="2004-10-25" version="1">MGSVSTQSQPCSQRERVSALVDGEAPEGLSLKQILAGLADAERATWAQYHLIGDALRSDELTLEPAESSAFMARFSASLAAEPHLLAPAAAPIARRLLAMRRRVVPAFAIAAAAATLTWIVVPQMQGVGAPGAVQVASVSPVQQGPLQRVAAAQTGAQDVNIIRDASLDQYLEAHQQFAQQPVVTGSMPVIRTAVTTQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SI1</accession>
    <name>Q63SI1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hlorohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527395.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108935.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2339"/>
    <dbReference type="EnsemblBacteria" id="CAH36342">
        <property type="protein sequence ID" value="CAH36342"/>
        <property type="gene ID" value="BPSL2339"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2339"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3080"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MCPTTER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="53"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="460" mass="49629" checksum="8DB776780A174455" modified="2004-10-25" version="1">MTKIDSMLFAEQAYLPGGWRRDVLLRWNAAGALVDVSADAAAPAGVARANGPLLPGMPNLHSHAFQRAMAGLTEYRANPSDTFWSWRDLMYRFALKITPDALAAVARWLYVEMLKSGYTSVCEFHYVHHAPDGARYARPAELAARVVGAARDAGIGITMLPVAYQYSGFGERAPRDDQRRFINTPDALLALVDALRGELPEHGGLRYGIAPHSLRAVSESGLRALVGAMPADAPVHIHIAEQTAEVDDCMRAYGARPVRWLLERFDVNARWCLVHATHLDAAETQALARSGATAGLCPTTEANLGDGIFPAVDYLAAGGAIGIGSDSHASVDWRAELRLFEYGQRLVRRERNVLADAAQTRVADRLFAASLAGGARAAGRAVGALEAGRRADWIVLDPAHPSIAEHGSDTWLSGAVFAEHGDTPVLDVYVGGERVVNARRHRDEEAAYAGYRAALAQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SI9</accession>
    <name>Q63SI9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108927.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36334">
        <property type="protein sequence ID" value="CAH36334"/>
        <property type="gene ID" value="BPSL2331"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2331"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2647"/>
    <dbReference type="OMA" id="VGESTWE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="95" mass="10853" checksum="97CD4F1276E696A9" modified="2004-10-25" version="1">MQMSEPIRITSLATIGEILQNRPTINRLILKQVGESTWEIIKHDGERPNNLHQVAERSGGKFAYERNVKRGFEALSGYDIDSDEQIKVVYRLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SX1</accession>
    <name>Q63SX1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL2200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192088.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108795.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2200"/>
    <dbReference type="EnsemblBacteria" id="CAH36202">
        <property type="protein sequence ID" value="CAH36202"/>
        <property type="gene ID" value="BPSL2200"/>
    </dbReference>
    <dbReference type="GeneID" id="56595987"/>
    <dbReference type="KEGG" id="bps:BPSL2200"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2498"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVCVMQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="294"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="337"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="549" mass="60071" checksum="29DE44386E743153" modified="2004-10-25" version="1">MSAAQIARGAGAPPSPSTPPHEPLLSIERLRVRFGGTLAVDDVSLAIGRGERVALVGESGSGKSVTALAILRLLRDADVSGAIRFAGETLADKSEREMRALRGADIAMIFQEPMTALNPLFTIGEQIGETIELHDGVSKRDARARAIALLARTGIDRPDERVDSYPHQLSGGQRQRAMIAMALACRPRLLLADEPTTALDVTIRAQIVELLLELQRDAAAERGMAVLLITHDLNLVRRFAERVAVMEKGRLVECGPVERIFDAPEHPYTQRLLHSRPQRTVSPVLPIAPVVLDARGVTVQFRQKLPGFAGWLRSGRFTAVSDASVSVRQGETLGIVGESGSGKSTLAMALLGLQRVAHGDIEFEGRSLASFRGRERVALRANMQVVFQDPFSSLSPRQTIGRIVSEGLELHRPRLTADARRDKVIAVLREVGLDRTVLHRYPHEFSGGQRQRIAIARALVLEPRVLVLDEPTSALDVSIQQQVLKLLSNLQRKYNLGYVFISHDLEVIGAMAHRVAVMQGGAIVETGDVERIFTEPVHPYTQKLLKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T85</accession>
    <name>Q63T85_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521805.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108681.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2082"/>
    <dbReference type="EnsemblBacteria" id="CAH36083">
        <property type="protein sequence ID" value="CAH36083"/>
        <property type="gene ID" value="BPSL2082"/>
    </dbReference>
    <dbReference type="GeneID" id="56526446"/>
    <dbReference type="KEGG" id="bps:BPSL2082"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.82"/>
    <dbReference type="eggNOG" id="ENOG5032SVH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPREDFI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039437">
        <property type="entry name" value="Put_lumazine-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12893">
        <property type="entry name" value="Lumazine_bd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="125" mass="14407" checksum="4F74733E0681499A" modified="2004-10-25" version="1">MEIDAISRALQIYFDVMYECDLEKFDLVFHPTSSLFTMKDGELSVRPFARYRSEIAARTPPKSVSQPRMDAILQIAVLSPEIAFAQVRVRLFEKVFIDNLNLLKFDGRWMIVAKIFHHARTIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TF0</accession>
    <name>Q63TF0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108616.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2018"/>
    <dbReference type="EnsemblBacteria" id="CAH36017">
        <property type="protein sequence ID" value="CAH36017"/>
        <property type="gene ID" value="BPSL2018"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2018"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2278"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLYHRFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017768">
        <property type="entry name" value="AcpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03397">
        <property type="entry name" value="acid_phos_Burk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="557" mass="59242" checksum="C5262DC6891BF21C" modified="2004-10-25" version="1">MDIHTTRRLARHAPAGPSIPTHLVRQERQRMNKHWIRVSPIALAAAIGLTACGGDDVTSPGLSAVKNVVVIYAENRSFDNLYGNFPGANGLQNVTAASAAQVDRDGTPLATLPKIWGGLTAAGVTPAVTEAMTANLPNAPFAIDDPNGFNTPMSVTTRDLVHRFYENQMQIDGGKNDKYAAWSDAGGLVMGHYTADPSKLPLWKLAQQYTLADNFFMGTFGGSFLNHQYLICACAPFYPNADKSPAASQISVVNPDGVTLTTASNSPASALSGPPKFVKSGGLTPDFYAVNTMQPPYQPSANAAPTGGDPNLADPANPSTLPPQTQQNIGDLLTSAGVSWAWYAGAWGAALQAAQSGTSGVIYGPNMTSPNFQPHHQPFNYYANQAPGSANRAQHLLDAGSNGAALIQAIDAGKLPQVTFYKPQGNLNEHPGYTDVASGDQHIADVIAHLQKSPQWNNMVVIVTYDENGGFWDHVAPPKGDRWGPGTRIPAFVISPFAKQGFVDHTQYDTASILRFITRRFALPKLAGLKQRDDALVANGFKPMGDLTNALTLSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TI3</accession>
    <name>Q63TI3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two component system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108583.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1985"/>
    <dbReference type="EnsemblBacteria" id="CAH35984">
        <property type="protein sequence ID" value="CAH35984"/>
        <property type="gene ID" value="BPSL1985"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1985"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2237"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTMDTHV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="27587" checksum="194842AC4AA01AC8" modified="2004-10-25" version="1">MDFVLRGAMRIAVLDDDQAQTDFVSQTLTAAGHTCYAFKEGKALKKRLQRETFDLLVLDWNVPDMSGEEVLKWVRANQVEHRLPIIFMTSRDDEAGITQILNAGADDYVVKPVSGPILRARIGSLLRRAYPVNAESSIREFDNYKFDANLKQAYVGDKPVSLTQKEFELALLLFQHLDRPLSRAHILDLVWKQATDIPSRTMDTHISMLRTKLGLRPENGYRLAPIYGYGYRLERVMQGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U02</accession>
    <name>Q63U02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fimbriae assembly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108414.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1815"/>
    <dbReference type="EnsemblBacteria" id="CAH35814">
        <property type="protein sequence ID" value="CAH35814"/>
        <property type="gene ID" value="BPSL1815"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1815"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2043"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGPDAIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="299"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="524" mass="55958" checksum="95685BF7EAC25FF5" modified="2004-10-25" version="1">MMFGRRPAASFAPGDAGGAHEFAPDAAPAGAGAAPAGGHASASDAGGAARAREPAGASGASAPGGAPQSGVAPSGHRPASRDDRIDRIDRDDGHDRAPAQDHHEALIRSETFKTIRAVVFSSMNMSAALMMSRAEVREGIEQAAADVIARERLTVTLAEQTLIVDEILNDMFGVGPIEPLLADERVTDILVNGPDQVYVERAGKLELTPLKFRDNAHVINVAQRIAAAVGRRVDESSPMVDARLADGSRVNVVLPPIAIRGASISIRKFAKRNITLARMAQQGNLSQAMVEVLKIASACRLNIVISGGTGSGKTTLLNALSHFIDSHERIVTIEDAAELQLQQPHVVSLETRPENSEGLGGVSQRDLVRNALRMRPDRIILGETRGPEAFDVLQAMNTGHDGSMTTIHANTPRDAITRLESMVMMANGNLPLVSIRRQIASAVHMILQIERMRDGVRRVTRVTEIAGMEGDVVITQDLFAFRYDASAFQEQVHGMFESSSLRPAFAQRAAYYGLEGALLGALQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U38</accession>
    <name>Q63U38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative siderophore related no-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205069.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108378.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1778"/>
    <dbReference type="EnsemblBacteria" id="CAH35777">
        <property type="protein sequence ID" value="CAH35777"/>
        <property type="gene ID" value="BPSL1778"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1778"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3885"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QACSQAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="538"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1646"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3193"/>
            <end position="3268"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1681"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="3290" mass="348650" checksum="599AF40636F6C947" modified="2004-10-25" version="1">MTSFPTALHHRIHALARLDPDAPALASFAPDTVRLTRGELDERAARLAAQLRAAGVGAEVPVGVCVARSCDLFVALLAVMKAGGAFVALDPRHPAARLDWVARDAGLAHGIVDASADAAMRARFARCFDVGGVAAADPAAPREHGGDVHPRAAAYMIYTSGSTGTPKAVVVEHGPLAAHGDALAESLPIGPDDRVLHFASVNFDVAIEAWLVPLAVGGSVVISDPPPFTPDAAHALISRERVTNTTLPPAYLREFAAVCAREGVPPSLRVLLFGGEAMSQDAFDEIRRVFPAIRLVNGYGPTETVISPMLWPVAPGTTPALDAGNGYASLPIGWPIGRRVARVERADGTVARGEAGELLLGGACLARGYHGRAALTAERFLPDPAGEPGARIYRTGDLARERADGAFDYLGRIDDQVQVRGVRVEPAEIAACLLTHPGVRDAGVLAETAGGRTQLIACVALAAPPRETPSGGDARGDAPPDDDALRAHVAAHLPAAWLPHRFVRFDKLPYTLNGKLDRVALRDAVAARPAEAAADVDAPRTDTERRVAALWQRLLNDPAPIGRVDRFFARGGDSLAAMQLQTAIRLDWRVNLRLDTLFDDAPLAELAARIDAAEREARQPAAIGTTARRAIAADAIDARATGQMGRTGAAGEATEATEAAGALERPASFAQQRFWVLARTQDAGAAYHVSFHWDIDGALDLGTLQRALDMLIARHEAWRTTLVENDDGVVLQRIHAALPVRIAAVDLRGEAGASRAARLAELTERHAGAPFDLSDGPLVRALLVTLADGAQRFLLTTHHAVSDGWSSRCAFAELTAAYAALAEGRAPELPALPIQYADYAQWQRDALDAHETARELAYWRGALDGAPAPLALPLDRPRAAERDYRGGRLARRLSPAASDAVRAAARRLHASPFTVLLAAFDAWLFRLTGERDLVVAAPIAQRARPETAPLVGLFLNTLALRARVSPAQSFESLVASVRDAAFGAFAHQDVPFDKVIDAVKPPVRRGDEWLRVKFAQQFDLECRASLPGAAVRMAPGLDTAARFDYALDFTDDPRGIEFVAAYARDGIDEATAHAWLDSFAALVEDAVREPRRPIAALAVAQAGAPCALIAGRPLATAPDVLALFAREAAEHPHRVALADADTRLTFAELDDASNRVALALRRDAARDEAPGAETPVAICIERSARFVVAFLGVLKSGAYAVPLDPASPCERIAAALAACGARRMLAAGALDALGEFDGVAVQDIDACAHDASLANAAAPRVPPQPEQAAYLIFTSGSTGAPKGVVVPHRALADYVAGMLDELAFAPHASMAMVSTVAADLGHTALFGALCSGRTLHLLPAQAAFDPDRFAHEMATREVGVLKIVPSHLHALLDAQRAADVLPAHALVTGGEALPWALVERIAALKPDCRVINHYGPTEASVGALVCDTSAPAQADLRAAAASSPGEAARGVPLGRPLPNAHACVLDAYGSSVPVGAIGELYLGGPGLARGYLGRAAASAERFVPHPHVAGARVYRTGDRVRLRADGRLDFLGRLDDQVKIRGYRVEPGEVSAALRALPGVAQAETLALEHEGRLRLAAFATPEAGARIAADALRDALAARLPDYMVPAALVVLDALPVTANGKIDRAALRARAAAPAPATAGDEDAPQGPIEATLAEVWRDVLKAARVGRHDNFFELGGDSILVLQVIARARKRGVKFTPKQLFDGPTLAELARVAVAIEADAPASGAAHGAAIGANAAAARRDEAVLTPAQLRFFALDIPRRGHWNQSIALDVAGAFDFDAFARAFDALLTHHPVFRERFAPTGDGGGWQRSAAPRAFDTLPLAAAAARDEADALAQFDALQATLDLTHGPLACAFAAVLPSGATKLYLAIHHAIVDGVSWRVLLDDLDAAYRAACERRAVRLGPTGASASEWAARLARAARDPAGPFAGELPYWAALAAPHDDLRPDRPDAAATNAHADVVIQTLDAALTREVLTDANAAYRTQAVELLIAALVAALGQHTGAAACRLELEGHGREALFDELDASRTLGWLTSHYPVAFAVEATPAATLAGVKDALRAVPNKGLGFGVLRHYGDDATRAALARVARPRVTFNYLGQFDAPRDAALVPRFGGAGRERDPAGPLGNALAIHAYVGANGERALKVHWVYGATQFDRATIDALAARFDAALRALAAACRARVAERGAGATPGDYPLARAGGLTQAALDRLPFDARAIDDIYPLSPMQQGILFHSLFAPERATYVNQLVATLVDPDVERLRAAFDAAVPRHDILRTGFAAHEAAPMQIVHRHARMPVEIVDWRGAHASPAALDTALDAWLAADRARGFDLAAPPLMRVTLIRTDDADWRLVWTRHHLLLDGWSTARLFADVLRDYIEPPRANPFAAPARTRYRDFIAWLARRDAQADRAFWLGRLARLDEPTHVAERAAAHEAAGRANWRATLPAADTARIGEAARRMKVTVNTIVQGAWALALQRITHRRAVAFGATVAGRPHALPDVDTVLGLFINTLPVITAPLPQLAARDWLASLQRDNAAALEHAHTPLYEIQQWAGLGGALFDTLVVFENYPVDEAWQGRDARALQKRDLRNIEATDFAVTLVIEAGDTLAIDYGYDPARIGPARVEALHRAFAACIAGLVDHPDAPLGTISCASADDLALIARANATELDWPAAQRAPLFAQFEAAARARPDAIALECFASSDGGDGARAQMRYGELDAKADRVAAALAASGVRPDSVVALCVERSFDMVVALVGTMKARAAYLPVDPDYPAERIAYLLGDAKPPVVITQAHLRARVDAALAGADAAVVTVDELLARAAGAEPEAERVAAAADVAPGQLAYLIYTSGSTGQPKGAGNTHGALANRIAWMQRAYRLAPDDVVLHKTPFGFDVSVWEFVWPLAVGAKLAIAAPGDHRDPARLVAAIDAHRVTTLHFVPSMLAAFVAYLDDFGAAARCASVRTIVASGEALAPELVARVAALLPHAQLHNLYGPTEAAIDVSHWRCTADDAAADAVPIGHPIANLRLHVLDAALHPAPVGATGELYLGGAGLARGYLGRAALTAERFVPDPFVPGARLYRTGDLARRRADGALDYLGRLDTQVKLRGQRIELGEIEALLRATDGVRDAVVIVRDERLVGYVACATPAGFDAAAQIERLRARLPAYMVPAQLVALDALPVTPNGKCDRRALPAPVFDARVVDAPRTATERALAAIWQRVLTLPQLGRDDDFFALGGHSLLAAQANAQANLQWSLTLPLRTIFDERTLARCAAAIDRARDAGRERDAAGAIDALLGELEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UH9</accession>
    <name>Q63UH9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subfamily S9C non-peptidase homologue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550392.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108237.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35622">
        <property type="protein sequence ID" value="CAH35622"/>
        <property type="gene ID" value="BPSL1623"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1623"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3686"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KDMPSAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="39544" checksum="0CC9B3FABB8EF655" modified="2004-10-25" version="1">MRRKKSSIWLPYFDLLSLTLRARPRQKVAKPKPSVTRPTSAAKTRSTKRTRAAHAGRTSADNARGTWLRSFHSARPAAGRLINHLAYALYLPAAPAAAASMPAVVMLHGCKQTAESFATGTRICDLAQRAGFAVLLPEQAKTSHSHRCWNWHGDSSQSEAPAVASLVDAIIRQYGFDRERIYLAGLSAGAGLAAGLAMRYPELFAAVGLHSGPVFGAPSSTLAAMSLMRGGSREDPLRVIENCVDVSDHPGMPALIVHGEHDTVVAKQNAMQLGLEFARINRLIDGQGTLRVGEQHVYSRKGVDYTDYLKSGRLVVRVCIVHGLRHAWSGGDPREAFHSATGPDATAMFWHFFRPRRRKRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UM7</accession>
    <name>Q63UM7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative TetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108189.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1569"/>
    <dbReference type="EnsemblBacteria" id="CAH35570">
        <property type="protein sequence ID" value="CAH35570"/>
        <property type="gene ID" value="BPSL1569"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1569"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1766"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGLCDGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="212" mass="23933" checksum="7680E6573DC90DF4" modified="2004-10-25" version="1">MLDFPAMKPIRLTREQSKDLTRERLLSAAHAIFTKKGYVAASVEDIASAAGYTRGAFYSNFRSKAELLIELLKRDHEEAEADLQKIFESGGTREQMEAHALEYYSQFFRNNPAFLLWGEAKLQATRDAKFRARFNEFVKEKRDRFTHYILTFAERVGTPLLLPADVLALGLMSLCDGVQSYHAADPRHVTGDAAQQVLAGFFARVVLARAPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UQ8</accession>
    <name>RIMO_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="1">S12 MTTase</shortName>
            <shortName evidence="1">S12 methylthiotransferase</shortName>
            <ecNumber evidence="1">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimO</name>
        <name type="ordered locus">BPSL1538</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108158.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UQ8"/>
    <dbReference type="SMR" id="Q63UQ8"/>
    <dbReference type="STRING" id="272560.BPSL1538"/>
    <dbReference type="EnsemblBacteria" id="CAH35539">
        <property type="protein sequence ID" value="CAH35539"/>
        <property type="gene ID" value="BPSL1538"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1538"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1729"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000374741" description="Ribosomal protein S12 methylthiotransferase RimO">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="143"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="391"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="459" mass="49705" checksum="7DA1781C673C3C34" modified="2004-10-25" version="1">MKSSGKPLAAPKVGMVSLGCPKALVDSEQIITQLRAEGYEISGTYDGADLVVVNTCGFIDEAVQESLDAIGEALAENGKVIVTGCLGAKKSASGSGLIAEVHPKVLAVTGPHAVGEVMQAVHSHLPKPHDPFVDLVPAAGIKLTPRHYAYLKISEGCNHRCSFCIIPSMRGELVSRPVAEVMLEAENLFKSGVKELLVISQDTSAYGVDVKYRTGFWNGRPLKTRMTELVGALGELAAQYGAWVRLHYVYPYPHVDEIIPMMAQGPLKGHVLPYLDVPFQHAHPEVLKRMKRPANAERVLERVQKWREICPDLTIRSTFIAGFPGETDAQFETLLDFIREAELDRVGCFAYSPVEGASANALDGALPDDVREARRARFMEVAEEVSAARIARKVGKTLKVLIDEVNAEGGIGRTAADAPEIDGVVYVEPAAKASKRYKVGEFVSVKITGADGHDLWGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VA0</accession>
    <name>Q63VA0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">DNA polymerase III subunit epsilon</fullName>
            <ecNumber evidence="3 6">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">dnaQ</name>
        <name evidence="8" type="ordered locus">BPSL1341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531112.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107966.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1341"/>
    <dbReference type="EnsemblBacteria" id="CAH35339">
        <property type="protein sequence ID" value="CAH35339"/>
        <property type="gene ID" value="BPSL1341"/>
    </dbReference>
    <dbReference type="GeneID" id="56595267"/>
    <dbReference type="KEGG" id="bps:BPSL1341"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.140"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHVYLNP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06131">
        <property type="entry name" value="DNA_pol_III_epsilon_Ecoli_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006309">
        <property type="entry name" value="DnaQ_proteo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01406">
        <property type="entry name" value="dnaQ_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="26147" checksum="A46477ED65484903" modified="2004-10-25" version="1">MRQIILDTETTGLNARAGDRIIEIGCVELLNRRLTGKNLHFYVNPERDSDPGALAVHGLTTEFLSDKPKFAEIVDPLRDFVRDAELIIHNAPFDLGFLDAEFALLGLPSFTDHCAGVIDTLVQAKQMFPGKRNSLDALCDRFGISNAHRTLHGALLDSELLAEVYLAMTRGQESLVIDMLDEAGDAHRNGDAPRMAFSGLDLPVLAATDAELAAHEAQLDALDKSAKGVCVWRKEAVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VA2</accession>
    <name>Q63VA2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative proline/betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198608.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107964.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1339"/>
    <dbReference type="EnsemblBacteria" id="CAH35337">
        <property type="protein sequence ID" value="CAH35337"/>
        <property type="gene ID" value="BPSL1339"/>
    </dbReference>
    <dbReference type="GeneID" id="56595265"/>
    <dbReference type="KEGG" id="bps:BPSL1339"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.144"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLVEMFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="37"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="495" mass="52257" checksum="06142C654B974487" modified="2004-10-25" version="1">MTATPAPSSSSSAPTEGALPAAAHEITVVDQGLLKRAVGAMALGNAMEWFDFGVYSYIAVTLGQVFFPSSSPSAQLLATFGTFAAAFLVRPLGGMVFGPLGDRIGRQRVLAMTMIMMAVGTFAIGLIPSYDSIGLLAPVLLLVARLVQGFSTGGEYGGAATFIAEFSTDKRRGFMGSFLEFGTLIGYVMGAGVVALLTASLSHDALLSWGWRVPFLIAGPLGLIGLYIRMRLEETPAFKRQAEAREAQDKAVPKAHFRRQLARHWRALLLCVGLVLIFNVTDYMALSYLPSYLSSTLHFDEAHGLVLILIVMVLMMPMTLATGRLSDAVGRKPVMLAGCVGLFALAIPALLLIRTGETALVFGGLLILGALLSCFTGVMPSALPALFPTEIRYGALAIGFNVSVSLFGGTTPLAAAWLVDATGNLMMPAYYLMGAAVIGAISVLALPESARQPLKGSPPAVASHREAHALAREIKRREAAERDDSGYPSAAALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD4</accession>
    <name>Q63VD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192322.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107932.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1308"/>
    <dbReference type="EnsemblBacteria" id="CAH35305">
        <property type="protein sequence ID" value="CAH35305"/>
        <property type="gene ID" value="BPSL1308"/>
    </dbReference>
    <dbReference type="GeneID" id="56595230"/>
    <dbReference type="KEGG" id="bps:BPSL1308"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.185"/>
    <dbReference type="eggNOG" id="COG5486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVSWGRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018688">
        <property type="entry name" value="DUF2182_TM_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09948">
        <property type="entry name" value="DUF2182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="265" mass="28308" checksum="DABF2606051A475B" modified="2004-10-25" version="1">MLNATSPRRVFVPLAIASIVAAWGALWTWDSSPYARFLHPVDWSATSLAGLCRLVPAGGAIVPAALHAAAWLLMIVAMMLPTVLPLLRTFERLTAARPERNRLMLLVVLGYLAAWSAFGLLAQAGDAGLHALARRAPWLAWHGWLVGAAVLALAGAYQFSPLKYRCVDKCRSPLMFVSEQWRGGHPRRDSFALGLRHGLFCVGCCWMLMCVMFALGAGSVGWMLAIGAAMAAEKNLPHGRRLSAPLGVALLGWAASIAVAGMGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VE3</accession>
    <name>Q63VE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204982.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107923.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1301"/>
    <dbReference type="EnsemblBacteria" id="CAH35296">
        <property type="protein sequence ID" value="CAH35296"/>
        <property type="gene ID" value="BPSL1301"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1301"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.201"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRRSWLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="32210" checksum="0313125F893D73E1" modified="2004-10-25" version="1">MTPPPKDAAALARPAAAAGPHAPPAVRRARRAPLDWLAAAQWAVTLALCAFLIVPVAMSVLAGLTVNYFRGPSSGLTLRWLGEVWAQYHGSVFLSLEVALATLAVTLVAGVPAGYALARSRSRVSRLIEEALVLPVALPGLASALALLSVYGGFAAFRTSLWFIVVGHVVFTLPFMVRAVAAVAARADLRTLEEGAASLGASFATRFATIVLPNLRPGIVAGALAVLTLSIGEFNLTWMLHTPDTKTLPVGLADTYASLRLEIGSAYTILFLLMTLPLLVAMQRLGVEPPGARDRTRDRTCKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL4</accession>
    <name>Q63VL4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526466.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107852.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1230"/>
    <dbReference type="EnsemblBacteria" id="CAH35225">
        <property type="protein sequence ID" value="CAH35225"/>
        <property type="gene ID" value="BPSL1230"/>
    </dbReference>
    <dbReference type="GeneID" id="56526631"/>
    <dbReference type="KEGG" id="bps:BPSL1230"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.296"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ISSGWMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="16724" checksum="FA8F8DB17399BC88" modified="2004-10-25" version="1">MGISYEDLEVGSRTEVGKHRFTADEIVTFAQAYDPQPFHVDAQAAKSSMFGGLVASGWHTCSVFMGMLVRGVLQGSTSMGSPGIEEIRWIKPVRAGDTITMYNKILDKRLSESKPDRGIVTTEWEGVDEQGETVITVRSKVIFGLRSPQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VS2</accession>
    <name>Q63VS2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">BPSL1172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
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        <property type="protein sequence ID" value="CAH35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1172"/>
    <dbReference type="EnsemblBacteria" id="CAH35167">
        <property type="protein sequence ID" value="CAH35167"/>
        <property type="gene ID" value="BPSL1172"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1172"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1293"/>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
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        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF81660"/>
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    </dbReference>
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        <property type="entry name" value="SSF81665"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="kdpB"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="526"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="686" mass="72352" checksum="ECBE55BA00CC5FF4" modified="2004-10-25" version="1">MFDPALVRPAIVDSFKKLTPRTQLRNPVMFCVYVGSILATILWIAALTGQAEAPAGFILAVALWLWFTVLFANFAEAIAEGRSKAQAASLRSAKKDVMAKKLNEPHPKSPVRIMTASDLRRGDVVLVEAGDTIPADGEVIEGVASVDESAITGESAPVIRESGGDFSSVTGGTRVLSDWIVVKVTANPGEAFLDRMIAMVEGAKRKKTPNEIALTILLVALTIVMLLATATLLPFSMFSVDAMHSGHVVTITALVALLVCLIPTTIGGLLSAIGVAGMSRMMQANVIATSGRAVEAAGDVDVLLLDKTGTITLGNRQASAFLPAPEVTEATLADAAQLSSLADETPEGRSIVVLAKERFNIRQRDMGALHAVFLSFSAHTRMSGVDLSPEREIRKGAADAVKKYVESHGGRFPAEVTNAVTDVARRGSTPLVVAEKRGALARVLGVIELKDIVKGGIKERFAELRKMGIKTVMVTGDNRLTAAAIAAEAGVDDFLAEATPETKLSTIREHQAAGRLVAMTGDGTNDAPALAQADVAVAMNTGTQAAKEAGNMVDLDSNPTKLIEIVEIGKQMLMTRGSLTTFSIANDIAKYFAIIPAAFATTYPQLNALNVMHLATPASAIMSAVIFNALIIVLLIPLALKGVKYRPLGAATLLRRNLLVYGLGGILVPFVGIKLIDVVLAALGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VV3</accession>
    <name>Q63VV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204955.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
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    <dbReference type="RefSeq" id="YP_107763.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
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        <property type="protein sequence ID" value="CAH35136"/>
        <property type="gene ID" value="BPSL1142"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1142"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1262"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERFINWK"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006433">
        <property type="entry name" value="Prohead_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04586">
        <property type="entry name" value="Peptidase_S78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="631" mass="66386" checksum="0ED92E37BBCAD839" modified="2004-10-25" version="1">MPMNRQISKFITKQTASVSNKAFSRFEVKNLDDGSRVLKGIASTPTPDRAGDTVVPQGIQFKTPFPLLWQHDPSKPIGTVNKMTVTAAGAEVEATIAPAGTAAYIDEAYNLIKAGLVPGLSIGFRPIDAEYDKATGGFLIKSCELFELSAVTIPANADAAVQSIKAHDKSRVGAPVVRLSAPIIKESDMTIAQQLAALAKKRADHLARQKALMDGAAADGTRTLNENEATEYDQIGLELKSLDTHEARLKEQQAIEAKSAVPVAGGPAAHSPVIVKPNVTKGTAFTRYAIALARSKGNLMQAAEIAKQWKDSTPEVEIVLKAAVAAGTTTDPAWAGPLVQYQDMASEFIELLRPATIVGRIEGMRRVPFNVRVPGQTTGSSVGWVGEGKPAPVSALAFNTTTLGFSKVAGIVAITEELARFSTPSAEGVIQQDLISTISQFLDQQFIDPAVAAGANGLSPASITNGVKAIPASGKDAAAVRADVKKVFQAYIAANLSVAGAVWIMSETTALSLSLMLNVMAQPEFPGLTMAGGTFFGLPAILSQTVGDNIVLAKASEILFADDGGVTLDVSREASLQMDSAPVAGATELVSLWQNGFIAMKAERFINWKRRRVEGVQYISGAAYGDAAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VW5</accession>
    <name>Q63VW5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="BPSL1129"/>
    </dbReference>
    <dbReference type="GeneID" id="56595078"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
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        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF69118"/>
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        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="16727" checksum="C2A97384FB150A9F" modified="2004-10-25" version="1">MAHAPRLPYPKLASKPFNALLHLSETVWGGSLGKPLVDLVFLRVSQINGCAYCIDMHWRDLVKLGVNERHLNAVAGWREAPFFDARERAALQWAESVARIPHTDPSDEAFAQLQAHFSDAEIAELGFAIATINAWNLLNVSFRNPIPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W14</accession>
    <name>Q63W14_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185903.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107702.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1080"/>
    <dbReference type="EnsemblBacteria" id="CAH35074">
        <property type="protein sequence ID" value="CAH35074"/>
        <property type="gene ID" value="BPSL1080"/>
    </dbReference>
    <dbReference type="GeneID" id="56594797"/>
    <dbReference type="KEGG" id="bps:BPSL1080"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.478"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LQMTASR"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="8">
        <location>
            <begin position="365"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="7">
        <location>
            <begin position="507"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="786" mass="86329" checksum="C960FA3BA0B3D78A" modified="2004-10-25" version="1">MSSSRSHAARAARPVRATRKSRRRRALFAIPLLGTLALALLWVAIIARLSVEKDSAFRDAGASAAILSTALEQHTVKAIHQVDQITRFVKYEFEKSPTRFNLASTVEKGVVPSDTLIQVSILDARGRLVANTAEAHPKPIDLSDREHFKVHMQRNDDDLYISKPVFGRVSRHWTLQMTRRLNHPDGSFAGVVVVSEDPAYFTNDFYNNATLGKDGVIAVISDTGAVLARSTGSTQKTPGTFSASGVYPVSERASGTYVDPIDGIVRIVSYRHLDGYPLGVMVGLSQAEEFADYHHTRNVYLLMTGFITLAMLAFFGVATGLIGKLLGREREMTQLAEFDLLTGLANRYATLRSLRNDVALPSNLSRLAILFIDLDNFKTVNDTLGHNAGDIVLQMTAARLSDAVANEGALARIGGDEFVVVVKGENVERRAERLAEAIVRMFAEPFDVRGSSFVLHASIGIALHSVENESEIDLLKKADLAMYSAKDAGKNCYQFYAPHLSHRADHLMRWEQQLRVALSDGQLFLAYQPKIDLTYRCITGFEALVRWDHPEHGVISANEFISIAESTGLIVPIGDFVIRTACEQLARWRNEGHDKLTLAVNISPVQFWRGDLIDTISRALAETGIEARRLELEITETAMMEYPELVSEKIVALKRLGIRVALDDFGTGYSSLSYLHRFAVDTLKVDRSFIQAIPADRSVCVMVSSIVHLARSLGLTVVVEGTETEEQIAWLAALGRIEAQGFLFSRPVPSDGIAALLARFGVCGGDSARAAGRDIANAAKQSFGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W22</accession>
    <name>Q63W22_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1071</name>
    </gene>
    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550743.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107694.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1071"/>
    <dbReference type="EnsemblBacteria" id="CAH35066">
        <property type="protein sequence ID" value="CAH35066"/>
        <property type="gene ID" value="BPSL1071"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1071"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.488"/>
    <dbReference type="eggNOG" id="COG5615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFFVWVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="16346" checksum="C7C65138DE1851AB" modified="2004-10-25" version="1">MSHAIAVALFLHLLAVAVWVGGMVFANFCLRPALSDLSPQLRLPLVEAVFGRFFNWVAGAVIVILLTGGFLLVKFGGAQATWPLHAMAGLGVVMMLIYGHIRFALFPRIRRAVQAQNWPDGARAVNAVRLLVMVNLVLGVVTIGAAVLSRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W53</accession>
    <name>Q63W53_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536027.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107663.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1037"/>
    <dbReference type="EnsemblBacteria" id="CAH35032">
        <property type="protein sequence ID" value="CAH35032"/>
        <property type="gene ID" value="BPSL1037"/>
    </dbReference>
    <dbReference type="GeneID" id="56526802"/>
    <dbReference type="KEGG" id="bps:BPSL1037"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.530"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIRPPQA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="226"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="437" mass="48061" checksum="BFAC6B3E58B48D55" modified="2004-10-25" version="1">MRKPIDSLFGRLALLVVCVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAERSPDQPLPSRVRLVAPGSGDVPEAKQDLPPPLKRFADDLRERLPAGTQVRIGRPGHPPVLWVKQPSDRDWIVVPVQPLRPPRSLDRMVLWLVMIFSAAVMAALFAAWQLQQPLSSLARAVARFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRLRAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDADRSEAVPVDQACERIARTYRAVSPNAPTVRTELAAGPGFRLPAATLDRVLSNLLDNAHAYGAPPVVIATARTATGYTLTVSDHGKGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQRTGGACEIGNREEGGLRVAMTFAFDVVPKAEPQTEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W69</accession>
    <name>Q63W69_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192728.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107647.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1019"/>
    <dbReference type="EnsemblBacteria" id="CAH35015">
        <property type="protein sequence ID" value="CAH35015"/>
        <property type="gene ID" value="BPSL1019"/>
    </dbReference>
    <dbReference type="GeneID" id="56596169"/>
    <dbReference type="KEGG" id="bps:BPSL1019"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.549"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIIMMST"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="252" mass="26195" checksum="85792151D614E423" modified="2004-10-25" version="1">MRLSGKTAVVTGAGSGFGEGIAKTFAREGACVVVNDLHAAAAERVASEIALAGGRALAVAGDVSRGEDWQALRDAALAAFGSVQVVVNNAGTTHRNKPVLDITEAEYDRVYAINMKSLFWSVQTFVPYFRGAGGGAFVNIASTAAVRPRPGLVWYNSTKGAMLTASKTLAAELGADRIRVNCVNPVLGETGLTSEFMGVPDTPENRARFVATIPLGRLSTPQDIANAALYLASDEAAFVTGACLEVDGGRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB4</accession>
    <name>Q63WB4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192718.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107602.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0974"/>
    <dbReference type="EnsemblBacteria" id="CAH34970">
        <property type="protein sequence ID" value="CAH34970"/>
        <property type="gene ID" value="BPSL0974"/>
    </dbReference>
    <dbReference type="GeneID" id="56596216"/>
    <dbReference type="KEGG" id="bps:BPSL0974"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.600"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIAGQAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042233">
        <property type="entry name" value="Cell_div_ZapA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34981">
        <property type="entry name" value="PTHR34981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="104" mass="11439" checksum="705678CC8851D2CF" modified="2004-10-25" version="1">MSTKQIEVSILGQTYRLACSAETEAALLEAVARVDAEMSKIRANSSVRGTDRIAVMAALSLASELLRLQQSVRHGEAFPAEEIRRTMRQMNEQLGAVLAQHEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WD2</accession>
    <name>Q63WD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysI</name>
        <name evidence="8" type="ordered locus">BPSL0956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192117.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107584.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0956"/>
    <dbReference type="EnsemblBacteria" id="CAH34952">
        <property type="protein sequence ID" value="CAH34952"/>
        <property type="gene ID" value="BPSL0956"/>
    </dbReference>
    <dbReference type="GeneID" id="56596236"/>
    <dbReference type="KEGG" id="bps:BPSL0956"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.621"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IKISGCM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="7">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="6">
        <location>
            <begin position="119"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="7">
        <location>
            <begin position="329"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="6">
        <location>
            <begin position="412"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="559" mass="62764" checksum="EABAC5CBC85D6234" modified="2004-10-25" version="1">MYQYDQYDQTIVDERVAQYRDQVRRRLSGELSEDEFRPLRLQNGLYMQRHAYMHRIAIPYGNLRSVQLRMLARIAREHDRGYGHFSTRSNIQYNWVKLEETPEILAKLASVQMHAIQTSGNCIRNITADQFAGVAQDEELDPRPWAEILRQWSTFHPEFAWLPRKFKIAVSGSKADRAAVQIHDLGVYLKKNDAGEVVASILAGGGLGRTPIVGAIIRENLPWQHLLTYCEAVLRVYNRYGRRDNLYKARIKILVKALSPAKFAQQVEAEWQHLKDGPSTLTQAELERVSQFFQPPAYEKLADTDASFEQHLLENRAFARWVERNVAPHKVPGYAAVTLSLKNHRVAPGDASAEQMEQVADWADAYSFGELRVSHEQNLILANVKKRDLFAVWEKAKAAGFATPNVGLLTDIIACPGGDFCSLANAKSIPIALAIQQRFDDLDYVYDLGDVSLNISGCMNSCGHHHVGNIGILGVDKDGAEWYQVSLGGEQGTGAGGARLGRVIGPSFSAEEVPDVISKLIDTFVESRIDGERFIDTYERIGIAPFKERVYAARQTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WE3</accession>
    <name>Q63WE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phage integrase/recombinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107573.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34940">
        <property type="protein sequence ID" value="CAH34940"/>
        <property type="gene ID" value="BPSL0944"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0944"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1028"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KSDNDYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="45788" checksum="5AE713D8B5568026" modified="2004-10-25" version="1">MKLESVPPCGSLELRKSGQGVLSFYWRVTLDGRTDRYPIGLYDSSAPPKSTSPTAKGFSLIAARAAAVAMAAKHYEAQEEGGIGPSWPVRRQRNRRSEMLPQRWDTRSTSSMAYMSSNSRSGIRRLRNKPEIYSPRTYALSFQKWRKRKQASKVTSAQIADVLRPLSSAGKRNTARKLKAYLSSAYERAKNPEQNATVSEALAKFKIKSNPVSDVAGVRQSRGADKNPLMPDEMRRYWRIIDVPGEEAALLRLHLMLGGQRIEQFVRMRNEHVQDDLITLIDTKGRSGTSRPIHLPRIPVIDEALKQLTPSGDFAISASPGRHLSPTTARAWAKRVVGDQLDGFELKRIRSGVATLLAKLGVSSEIRNHLQSHNLTGVEHRHYNKYDFYKEKKAALERMHKFLVSGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WH0</accession>
    <name>ISPH1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1</fullName>
            <shortName evidence="1">HMBPP reductase 1</shortName>
            <ecNumber evidence="1">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispH1</name>
        <name type="synonym">lytB</name>
        <name type="ordered locus">BPSL0919</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186453.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107546.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WH0"/>
    <dbReference type="SMR" id="Q63WH0"/>
    <dbReference type="STRING" id="272560.BPSL0919"/>
    <dbReference type="EnsemblBacteria" id="CAH34913">
        <property type="protein sequence ID" value="CAH34913"/>
        <property type="gene ID" value="BPSL0919"/>
    </dbReference>
    <dbReference type="GeneID" id="56594775"/>
    <dbReference type="KEGG" id="bps:BPSL0919"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.662"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000128793" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <sequence length="326" mass="35162" checksum="2C2A55039AFE5D4C" modified="2004-10-25" version="1">MSSTDTLSGQVAAADAEILLAQPRGFCAGVDRAIEIVERAIAMHGAPIYVRHEIVHNKYVVEDLKKKGAIFVEELEEVPSGNTVIFSAHGVSKAVRDEAAVRGLRIYDATCPLVTKVHVEVAKMRQEGVDIVMIGHKGHPEVEGTMGQVERGMHLVESVEDVRRLELPDPERVALVTQTTLSVDDAAEIIGALKAKFPAIREPKKQDICYATQNRQDAVKFMAPQCDVVIVVGSPNSSNSSRLREVAEKRGVAAYMVDAPEQIDPAWVAGKRRIGVTAGASAPEVLAQAVIARLRELGVTNVRALEGIEENVSFPLPRGLNLSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WK5</accession>
    <name>Q63WK5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541651.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107511.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0886"/>
    <dbReference type="EnsemblBacteria" id="CAH34878">
        <property type="protein sequence ID" value="CAH34878"/>
        <property type="gene ID" value="BPSL0886"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0886"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.705"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYGAYHD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="201" mass="21806" checksum="903D91D2F43AF1F2" modified="2004-10-25" version="1">MDRTTLDAYDRHAADYAREWDEQPPPDDMYVLLERYFEPGPTADVGCGAGRDVAWLARRGFDACGYDGSASLIAEARRSHPALRFEQALLPALAGAPSGAFRNVLCETVIMHLPASEVGAAVARLVELLAPGGTLYLSWRVTAGDAQRDGRGRLYAAVDAERVHAALGDACDVLFEHEQTSESSGKRVHRLVVRRRAAEAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WM5</accession>
    <name>PLSY_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">G3P acyltransferase</fullName>
            <shortName evidence="1">GPAT</shortName>
            <ecNumber evidence="1">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="1">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsY</name>
        <name type="ordered locus">BPSL0866</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522633.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107491.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WM5"/>
    <dbReference type="SMR" id="Q63WM5"/>
    <dbReference type="STRING" id="272560.BPSL0866"/>
    <dbReference type="EnsemblBacteria" id="CAH34858">
        <property type="protein sequence ID" value="CAH34858"/>
        <property type="gene ID" value="BPSL0866"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0866"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.730"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000188340" description="Glycerol-3-phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <sequence length="203" mass="21404" checksum="C5883B53C5B9C0E8" modified="2004-10-25" version="1">MQILLATVAAYLIGSVSFAVVVSAAMGLADPRSYGSKNPGATNVLRSGNKKAAILTLVGDAFKGWLAVWLVKRFGIGGEIGVALAAIAVFLGHLYPVFFRFQGGKGVATAAGVLLAVHPVLGLATALTWLIVAFFFRYSSLAALVAAVFAPIFDVFLFGTRDNPVAWAVLAMSVLLIWRHRSNISKLLAGEESRIGQKKKTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WT0</accession>
    <name>Q63WT0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189454.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107436.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0811"/>
    <dbReference type="EnsemblBacteria" id="CAH34803">
        <property type="protein sequence ID" value="CAH34803"/>
        <property type="gene ID" value="BPSL0811"/>
    </dbReference>
    <dbReference type="GeneID" id="56596554"/>
    <dbReference type="KEGG" id="bps:BPSL0811"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.792"/>
    <dbReference type="eggNOG" id="COG3427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RRTINFK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="26575" checksum="B9CBFC5FD0DBE048" modified="2004-10-25" version="1">MELNDALYIPLAPSVVWDALQDLALVRASLDHCESFSRLARGEYALALTVPLGPLRARYDVRAHVVGERHDEPVHTRRTLNFRARADGIGALRGQIDVVLAPADDERGASRRAPTTRIEYAVWATASGPLAELPGRQIQNALHELADDFFNEFCAVVQAKHGLAPNRARDGAPQRQHVFLRPAAFTGIARRAHAQHLGGALTGRAASALHHRESNPVPLWAWAVMIFFVALLLYAARWLNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X33</accession>
    <name>Q63X33_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107333.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0704"/>
    <dbReference type="EnsemblBacteria" id="CAH34697">
        <property type="protein sequence ID" value="CAH34697"/>
        <property type="gene ID" value="BPSL0704"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0704"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.768"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LILERQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="171"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="439" mass="48855" checksum="FF3CAB7E629E0C54" modified="2004-10-25" version="1">MILIVDDEPSILSALKRLLRTARYQVVTAESGAAALDVLAVGEVDLIISDMRMPCMTGAEFLARAQTLHPDTMRILLTGYSEIDAVVSAINEGGVYRYLNKPWDDHDLLLTVRQALEQRRLRQETARLFALTQKQNEELVAFSTELEAQVHARTEEIRQTVMFLEDAQRDLKRNFMTMIQVGANMIELRCGVMGGESRRIGELAKRLALALDMSELQAQDLYFAGLLHGIGKLSLPDELLRKSIDRMSAEESRLYHQHPLRAQMVLTPVTQLNHVAHIIRHQYERFNGRGTPDGLAGDDIPLGSRILAIARDYEGLQRGGVVNQRLQSEQAIALIKSQAGLRYDRQVVDRFVALVKDLATLGCNTPYARITGGQLLEGMRLADDLRTSRGVLLMTKGSVVSAHQVALVRRYEAQESTPFAILIQTTTLAEAAASAGREC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-11-23" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X54</accession>
    <name>AROA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="1">EPSP synthase</shortName>
            <shortName evidence="1">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroA</name>
        <name type="ordered locus">BPSL0683</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550856.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107312.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63X54"/>
    <dbReference type="SMR" id="Q63X54"/>
    <dbReference type="STRING" id="272560.BPSL0683"/>
    <dbReference type="EnsemblBacteria" id="CAH34676">
        <property type="protein sequence ID" value="CAH34676"/>
        <property type="gene ID" value="BPSL0683"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0683"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.935"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000088238" description="3-phosphoshikimate 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="1">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="451" mass="48627" checksum="E1B61DE73CCC5233" modified="2004-10-25" version="1">MTTSDRLQPSFVEVKNTSTLSGTIDLPASKSSSTRALLTAALTPGISTIRNVATGFNSNAMKHNCERLGASFSSEGDTTVVKGVDVMHVDREIVFDPGNSGVVLRLLMGVAGYLPDTRFVTQYRYSLGVRSQAEMVAALRRLNVECEAVGPEARLPISMRSTRALGKHTEVSCKKSSQFLSGLLYLGAIGERDLEIDVVDHITAPSMVHTTINNLAHAGVAVEYDAAFRRFFVPGRDRFKPSEFTVGADPASTAAILALCGSLASDVTLNGFFEEELGSGAVIRYLTDTGTLIDELPGNRIRIRGGASIRAQDFDGSLAPDAVPALAGRAAFAEGTSTFYNIEHIRYKESDRISDFRRELDKLGVRSEEKLDQLIIHGNPRSYRGGAVVDGHYDHGLIMALTTIGLHCEHPVLIKEPHHVGQTYPDYFADIGSIGANVDGLIYPNVAAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X74</accession>
    <name>Q63X74_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="5">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glyoxalase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gloA</name>
        <name evidence="13" type="ordered locus">BPSL0663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-S-lactoylglutathione = glutathione + methylglyoxal</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189937.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107292.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0663"/>
    <dbReference type="EnsemblBacteria" id="CAH34656">
        <property type="protein sequence ID" value="CAH34656"/>
        <property type="gene ID" value="BPSL0663"/>
    </dbReference>
    <dbReference type="GeneID" id="56596642"/>
    <dbReference type="KEGG" id="bps:BPSL0663"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.957"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWGTESY"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="129" mass="14734" checksum="ECE790C532BBD806" modified="2004-10-25" version="1">MRLLHTMLRVGDLDRSIKFYTELLGMKLLRRQDYPDGKFTLAFVGYGDERDHTVIELTHNWDTKSYELGTGFGHLALEVEDAYKACEQIKAQGGKVTREAGPMKHGTTVIAFVEDPDGYKIEFIQRNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X95</accession>
    <name>Q63X95_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550867.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107271.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0642"/>
    <dbReference type="EnsemblBacteria" id="CAH34635">
        <property type="protein sequence ID" value="CAH34635"/>
        <property type="gene ID" value="BPSL0642"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0642"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.980"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="11066" checksum="1BF87050F8EB1FBB" modified="2004-10-25" version="1">MPIYAYRCEACGYAKDVLQKMSDAPLSQCPECGQDAFRKQVTAAGFQLKGSGWYVTDFRGGSSGSSAPAAGGEKAGGEKAGGETAAAPAAADSTASAPAASTPAPAAAPASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XD1</accession>
    <name>Q63XD1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">manC</name>
        <name evidence="12" type="ordered locus">BPSL0605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mannose-6-phosphate isomerase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204841.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107234.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0605"/>
    <dbReference type="EnsemblBacteria" id="CAH34598">
        <property type="protein sequence ID" value="CAH34598"/>
        <property type="gene ID" value="BPSL0605"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0605"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1025"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006375">
        <property type="entry name" value="Man1P_GuaTrfase/Man6P_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01479">
        <property type="entry name" value="GMP_PMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="11">
        <location>
            <begin position="346"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="530" mass="57036" checksum="D9453EDF8B45DDC9" modified="2004-10-25" version="1">MTDLATKPTPAASHGTLPRILPVILAGGSGTRLWPLSREHHPKQLIDLIADESPLSATARRLTGIANAELADALLLVCGEQHRFTSAAQVSARGLDARILLEPAARNTAPALTLAALEALAHHGDPVLAAMPADHAVSDTRAFQETIALAARYAQDGAIVTLGVLPRRAETGYGYIKVGAPLAGANGDTGGYAIDSFVEKPHQELAQQYLQSGDYWWNSGIFVVRASTWLAAIRALQPDMHAACEAAWRGGTSEGAFFKADAAAFAACPSDSIDYAVMERLTGARALGIPGVIVPLTAGWSDVGSWDAIWELLPKDEAGNVARGEVLFEGTEDSFARSEGRLVACVGLKDVVVVETPDAVLVANKHRVQDVKTVVARLKSGRHEQVRDHRKVQRPWGYYDSIDRGERFQVKRIVVDPGKQLSLQMHYHRAEHWIVVRGTAKVTRGDETFLLSENESTYIAVGAVHRLENPGRIPLEIIEVQSGDYLGEDDIVRFDDRYGRASTQHAPDAAKPADAERAPAAGPARALGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP8</accession>
    <name>Q63XP8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107117.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0492"/>
    <dbReference type="EnsemblBacteria" id="CAH34481">
        <property type="protein sequence ID" value="CAH34481"/>
        <property type="gene ID" value="BPSL0492"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0492"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.550"/>
    <dbReference type="eggNOG" id="ENOG5033QBD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRMGTKR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="397" mass="43330" checksum="64C1D72204000676" modified="2004-10-25" version="1">MSASPLRPTPPARVARTTRLTPPTARLPMMPDTALPDTPDTPARTFPAAAHADAADLPTLAAQPVRERLAAFGAPPAALDALLRAGATRLLDSDMIIAQPRAHAAARAAERATTPLRYEQSAQTEAVLEQIAHEGLAPHFKPFMRGFSHVMSALFLTPEQDAKVQAYRAAGHHLRFLMSDGGGPALAGWRSTVRVEHGRTRLAIDKVWGIEAHRESIGLVAVRAPGAFMPAAYLVWPEQYRTLERAACGEPFLEGGLQLGNVRGEIETTPEDRLRIGGPNVFNKYLTIVRPYFVRALMAHVGWLAREGRLALSPAHESVRRFVADAARAQSRSSVYGADVVQRVLALKFAANELLGDLVRGGAVRRFDDQRDLLALSKMEGSAYRCYYEIRMGTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XT2</accession>
    <name>Q63XT2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome aa3 subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Cytochrome c oxidase polypeptide III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL0458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197994.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107083.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0458"/>
    <dbReference type="EnsemblBacteria" id="CAH34446">
        <property type="protein sequence ID" value="CAH34446"/>
        <property type="gene ID" value="BPSL0458"/>
    </dbReference>
    <dbReference type="GeneID" id="56594487"/>
    <dbReference type="KEGG" id="bps:BPSL0458"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1199"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALLWPDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01665">
        <property type="entry name" value="Cyt_c_Oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033945">
        <property type="entry name" value="Cyt_c_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="11">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="32276" checksum="7A74B682CD702D3E" modified="2004-10-25" version="1">MTGQNESPYYFVPHPSQHPISAAVGLLIMLGSFALWVNGEPWAPYTALVGLLWLLFVLYHWFGDAIAESEGGMYGKRVDKSYRWSMSWFIFSEVMFFGAFFGALFYAREIAMHQLGSLDYKLIWPDFSAVWPNEGPGALVGHFKTMGPWPIPTLNTALLLSSGATLTVSHHALREDHRRKAIAWLAATLVLGVCFLFLQGFEYFHAYNELNLTLGSGVYGSTFFLLTGFHGFHVFLGGTMLAVVLARMIRGHFKPDHHFAFEGAAWYWHFVDVVWLGLYVVVYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XT6</accession>
    <name>Q63XT6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ctaD</name>
        <name evidence="10" type="ordered locus">BPSL0454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197996.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107079.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0454"/>
    <dbReference type="EnsemblBacteria" id="CAH34442">
        <property type="protein sequence ID" value="CAH34442"/>
        <property type="gene ID" value="BPSL0454"/>
    </dbReference>
    <dbReference type="GeneID" id="56594483"/>
    <dbReference type="KEGG" id="bps:BPSL0454"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1203"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PVDFQYH"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01663">
        <property type="entry name" value="Cyt_c_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033944">
        <property type="entry name" value="Cyt_c_oxase_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="535" mass="59529" checksum="BEEAF113ADF9D113" modified="2004-10-25" version="1">MSSIGHDVAAGHAHDDHAHETPHGWRRWLFATNHKDIGTLYLLFSFIMFLSGGVMALAIRAELFEPGLQIMRPEFFNQLTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARMNNFSFWLLPVAAVLLVGSFFSPGGATAAGWTLYAPLSTQMGPGMDFAIFAVHIMGASSIMGGINIVVTILNMRAPGMTLMKMPMFAWTWLITAYLLIAVMPVLAGAITMVLFDRHFGTSFFNAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQVIPAFARKPLFGYSSMVYATASIAILSFMVWAHHMFVTGMPVTGQLFFMYATMLIAVPTGVKVFNWLATMWRGSLTFETPMLFAIGFLFVFTMGGFTGLMLAMAPLDIQYHGTYFVVAHFHYVLVAGSLFALFAGWYYWAPKWTGWMYNETRGKIHFWASMIFFNVTFFPMHFVGLAGMPRRYADYPAQFTDFNQLATIGAFGFGLAQVYFLFAIVLPAYRGGGELERASDKPWDGATGLEWTVPSPAPFHTFEHPPTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y14</accession>
    <name>Q63Y14_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189357.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107001.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0375"/>
    <dbReference type="EnsemblBacteria" id="CAH34363">
        <property type="protein sequence ID" value="CAH34363"/>
        <property type="gene ID" value="BPSL0375"/>
    </dbReference>
    <dbReference type="GeneID" id="56594618"/>
    <dbReference type="KEGG" id="bps:BPSL0375"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1293"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQQARFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="348"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="548" mass="58846" checksum="F2387F65F05AC964" modified="2004-10-25" version="1">MARTAPAGALVALHHVSFRFDDGVTLFDSLDLTFDRAPSAIVGRNGAGKSVLARLIAGRLAPTAGAIERHASIAFVAQHDADAMHDSRCTAAAVARLDAPLAALERVARGDARADDFDLLDGRWDLAERWQAALDEAGLPPLDARTPAHALSGGQLARVAMIGALLSGADLLVADEPTNHLDAPGREWLRAALAGWRGGLVVVSHDRALLADVERIVELTPRGARVYGGNYAAYRAQRDAEAQAAQAALDHAHAERERERRRLAREHDTIQRHAAATRRYAETANLPSGKRVSLKNSAREIMGRVRRDHRDTKTALGDAVQAAAARIEPDAPVLVSLPGTEIAARRRLFTLDAARLPWLPAHARAATVTWSAHGPARIALTGPNGCGKSTLLRMLAGECAPRAGRCDTHVPLAYLDQRLALLDPRRSVVEQLAALRTPLGQGELRSRLALLQLDATRATQPSARLSGGERLKAALACALWRETPAQLLLLDEPTNHLDLESVRAFEAALADFPGAIVAVSHDAAFIDALAPTHAMRWTSEGWRFEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YD8</accession>
    <name>Q63YD8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dipeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppB</name>
        <name evidence="7" type="ordered locus">BPSL0250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525885.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106877.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0250"/>
    <dbReference type="EnsemblBacteria" id="CAH34238">
        <property type="protein sequence ID" value="CAH34238"/>
        <property type="gene ID" value="BPSL0250"/>
    </dbReference>
    <dbReference type="GeneID" id="56527507"/>
    <dbReference type="KEGG" id="bps:BPSL0250"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1459"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPGMGTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="336" mass="36310" checksum="7A5663996CFC038A" modified="2004-10-25" version="1">MFRFVLRRVGMVIPTFIGITVLAFALIHLIPGDPIEVMMGERGVDPTMHAQALHRLGLDEPLPMQYLHYVGRALHGDLGTSIITNTSVMGEFLARFPATVELSLCALAFALALGLPAGVFAALRRGTIVDHGVMGTALTGYSMPIFWWGLILIMVFSATLGWTPVSGRIAVEYEIPHTTGFMLIDTLLSGEEGAFASAVSHLILPAIVLGTIPLAVIARMTRSSMLEVLREDYIRTARAKGLSPARIVVVHALRNALIPVVTVIGLQVGTLLAGAVLTETLFSWPGVGKWLIDAIGRRDYPVVQGGILMIATLVIVVNLVVDLLYGVLNPRIRHTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YI3</accession>
    <name>HSLV_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="1">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslV</name>
        <name type="ordered locus">BPSL0204</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203414.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106832.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YI3"/>
    <dbReference type="SMR" id="Q63YI3"/>
    <dbReference type="STRING" id="272560.BPSL0204"/>
    <dbReference type="MEROPS" id="T01.006"/>
    <dbReference type="EnsemblBacteria" id="CAH34191">
        <property type="protein sequence ID" value="CAH34191"/>
        <property type="gene ID" value="BPSL0204"/>
    </dbReference>
    <dbReference type="GeneID" id="56594449"/>
    <dbReference type="KEGG" id="bps:BPSL0204"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1513"/>
    <dbReference type="eggNOG" id="COG5405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IMKGNAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <feature type="chain" id="PRO_0000148098" description="ATP-dependent protease subunit HslV">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <sequence length="178" mass="19053" checksum="45A55775B1B09B7A" modified="2004-10-25" version="1">MEQFHGTTILSVRRGDKVALGGDGQVTLGNIVMKGGARKVRRIYNNQVLVGFAGGTADAFSLLDRFEAKLEKHQGNLTRAAVELAKDWRTDRLLRRLEAMLIAADATTTLVITGNGDVLDPEGGICAIGSGGSYAQAAARALAENTDLSPREIVEKALGIAGDMCIYTNHNRIIETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YQ2</accession>
    <name>Q63YQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524466.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106763.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0135"/>
    <dbReference type="EnsemblBacteria" id="CAH34122">
        <property type="protein sequence ID" value="CAH34122"/>
        <property type="gene ID" value="BPSL0135"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0135"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1586"/>
    <dbReference type="eggNOG" id="ENOG5032BGF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMVGDFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="65" mass="7400" checksum="F90434D6FBD850A0" modified="2004-10-25" version="1">MRAPLSELELRAAWSRLRMVGDFDMAPPAVRLVVESAARAMQNREYVRLRCSFDAKRCAANDTND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR6</accession>
    <name>FMT_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">BPSL0122</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549892.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106749.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YR6"/>
    <dbReference type="SMR" id="Q63YR6"/>
    <dbReference type="STRING" id="272560.BPSL0122"/>
    <dbReference type="EnsemblBacteria" id="CAH34108">
        <property type="protein sequence ID" value="CAH34108"/>
        <property type="gene ID" value="BPSL0122"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0122"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1601"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000082937" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="327" mass="33914" checksum="CFFD0C7A2BDF9CCD" modified="2004-10-25" version="1">MTHSLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASAVKRYALERGMAVAQPPSLRRAGKYPAEAVAALDLLHATPHDVMVVAAYGLLLPQEVLELPRHGCINIHASLLPRWRGAAPIHRAIEAGDAETGVTLMQMDAGLDTGAMLHEARVAIAPDDTTATLHDKLAAAGARLIVDALVELERTGALAATPQPADGVTYAEKIGKHEAALDWRKPAAALARQVRAFDPFPGGAGTLDGATLKLWAADAVPGRDDAAPGTIVDIGPDGVVIACGEGALRVTQLQKPGGKRLPAREFLAGAPLAVGQRFAPADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS1</accession>
    <name>Q63YS1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcription regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189230.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106744.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0117"/>
    <dbReference type="EnsemblBacteria" id="CAH34103">
        <property type="protein sequence ID" value="CAH34103"/>
        <property type="gene ID" value="BPSL0117"/>
    </dbReference>
    <dbReference type="GeneID" id="56596714"/>
    <dbReference type="KEGG" id="bps:BPSL0117"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1607"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TCIYALR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="38828" checksum="136416F7DE8DAE40" modified="2004-10-25" version="1">MDHLQSMRVFVKVADLGSFARAASAMDISNAVATRHVADLEGRLGTRLLNRTTRSLSLTESGQVYLERARQILDELEDVEQMVVARNHEPVGTLRVVAPVVFGLHNLAPVLQTYTQRFPKVIPDLTLVDRQVDLVEEGFDVGIVITRQMRSASIVTRRLTTGCMVVCATPSYLEKHGMPTHPEQLVEHPCLSLPSEYWGDERVFTGPDGEVRVRPSNVVVANNTEMLRQFAMLGMGVAILPSYLIGSDIARGKLVRLLSDYRLPQVEINIAYPSRRHLPAKVRTFIDHLVEHFSQSPDTMLGEQWATQGVAGQHVDALPADALAERSSADPALSPRLPRAPRARTVVPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-10-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V7T1</accession>
    <name>Q3V7T1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fliR</name>
        <name evidence="11" type="ordered locus">BPSL0032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525780.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106657.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0032"/>
    <dbReference type="EnsemblBacteria" id="CAH34015">
        <property type="protein sequence ID" value="CAH34015"/>
        <property type="gene ID" value="BPSL0032"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0032"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1714"/>
    <dbReference type="eggNOG" id="COG1684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APQFNIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="27327" checksum="A671D2365EB7444F" modified="2005-10-11" version="1">MFSVTYAQLNGWLTAFLWPFVRMLALVAIAPVTGHRSTPVRVKIGLAGFMALVVAPTLPPIPVATVFSAQGVWIIVNQFLIGAALGFTMQIVFAAIEAAGDIIGLSMGLGFATFFDPHSSGATPVMGRFLNAVAILAFLAFDGHLQVFAALVDSFRLVPVSANLLRAAGWQTLVAFGAAIFEMGLLLALPVVAALLIANLALGILNRAAPQIGIFQVGFPVTMLVGLLLVQLMAPNLIPFVGRLFDTGVDFVGRVAAGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I04</accession>
    <name>Q63I04_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative monooxygenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188561.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112268.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63I04"/>
    <dbReference type="STRING" id="272560.BPSS2265"/>
    <dbReference type="EnsemblBacteria" id="CAH39751">
        <property type="protein sequence ID" value="CAH39751"/>
        <property type="gene ID" value="BPSS2265"/>
    </dbReference>
    <dbReference type="GeneID" id="56598373"/>
    <dbReference type="KEGG" id="bps:BPSS2265"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5870"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRPFNDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="449" mass="49314" checksum="8A24FE7101153F0A" modified="2004-10-25" version="1">MTRKHIHFGVLIQGAGANMNAWKHPSVPPDASVNFDFYVDRARRAENAGIAFAFIADSAYVTPKSAPHFLNRFEPISLLSALAVLTSKIGLVGTMSSSYSEPYNVARQFASLDLISGGRAGWNVVTSSIEGTGKNYGRPHPDHAQRYAIAAEHLDVVQGLWDSWDDDALVRDRATGRFFDPDKLHRLDHRGRFFSVEGPLNIRRSPQGQPVIFQAGSSDDGIDLAGRSADAVFSNGSTFDEARVFYRRVKAAAAAAGRNPDHVKVFPGIGPIVGATQQEADDKYRQVRDLLSPREALAYLSHFFQQHDFSVYPLDGPFPDIGTLGSDGFQSTTDNIKRLARERKLTLREVAYEVSTRRSNIGTSEAFIGTPEAVASEMIRWVDEGAADGFMLGLPVTGFGLDDFVDHVLPVLSARGYFDPVRRGATLRDHLGLPYKESRYARDAQVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I13</accession>
    <name>Q63I13_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541998.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112259.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2256"/>
    <dbReference type="EnsemblBacteria" id="CAH39742">
        <property type="protein sequence ID" value="CAH39742"/>
        <property type="gene ID" value="BPSS2256"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2256"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5859"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WFIGDIL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="22291" checksum="CC3E95A7C9BA8A40" modified="2004-10-25" version="1">MAVTDARARGAVLLDKDGTLLENVPYNVDPARMRLARGAARALATFGELGMPVAVVSNQPGVALGRFPETALGAARHRLAELFAQQGAMLAGFFYCPHHPAGTVVRYACDCACRKPQPGLLFRAAAQLGVSLDASWMIGDILDDVEAGRAAGCRTILVDCGNETEWRYGGLRTPDFIASRLDDAAWIVARECAATAAAPAAPGEAPQEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I30</accession>
    <name>Q63I30_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552259.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112242.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2239"/>
    <dbReference type="EnsemblBacteria" id="CAH39725">
        <property type="protein sequence ID" value="CAH39725"/>
        <property type="gene ID" value="BPSS2239"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2239"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5838"/>
    <dbReference type="eggNOG" id="ENOG5031C5Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EDIHTFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="188" mass="19808" checksum="A8EDE04668457F12" modified="2004-10-25" version="1">MAMIVAGRFTTFEQAEAGARHLYARDFGPDDVSVFFLNPSGQHARFPIGGDVYADSAARPGGSGAAYGAALGVIVGLVVGFAVYMFGWRYWVVWPAAALVGGYVGAFGGALRRMQGRQIEGLGTLRQSDTGVMLAAHVTGETAGAVEAVLRASGAANVERVDGEWVDGEWADFDPARPPRTRPDVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I69</accession>
    <name>Q63I69_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529414.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112203.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2201"/>
    <dbReference type="EnsemblBacteria" id="CAH39686">
        <property type="protein sequence ID" value="CAH39686"/>
        <property type="gene ID" value="BPSS2201"/>
    </dbReference>
    <dbReference type="GeneID" id="56531710"/>
    <dbReference type="KEGG" id="bps:BPSS2201"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5786"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTAQIPI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="13640" checksum="B0404D2E49F094A5" modified="2004-10-25" version="1">MPELIPVDLPEPAQPFSWATHAHGLMFTAHGPVDAAGAIAGGDIAQQARLTLSNLAAAVRAAGAHLRDVAQVLLYVADARDIPTIDAVYREFFAAPYPNRACVAVRGFAHPDMRIELVAHVALGRAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I81</accession>
    <name>Q63I81_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pilus assembly-related, exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523372.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112191.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2189"/>
    <dbReference type="EnsemblBacteria" id="CAH39674">
        <property type="protein sequence ID" value="CAH39674"/>
        <property type="gene ID" value="BPSS2189"/>
    </dbReference>
    <dbReference type="GeneID" id="56531722"/>
    <dbReference type="KEGG" id="bps:BPSS2189"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5772"/>
    <dbReference type="eggNOG" id="COG3745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFAKQWM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267214" evidence="1">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="28816" checksum="C2A16135311C38F6" modified="2004-10-25" version="1">MKNSRAFTMLAIAILAGLAAVAFASRWLVQTSSSAVTPVAVAATDVSLGEPLGPNQLRIVNWPTASVPPGAFTDLKPLEGRVVRTSLARGEPVLGTKLAPVGTKGGLSAVIAPGHRAITVRVNDVVGVAGFALPGNYVDVIVNTQEQSKADPQQSISKIVLEKILVLAVAQQVSRDDTAPKVVNAVTLEVSPEQAEKLDLARSVGTLSLVLRNQVDKDALSTGGATKNTLLGQPAAAPAPIAAPAAQPRPVRTRVVAHARAAAGRDCVGVLSGVTGSVECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IM0</accession>
    <name>Q63IM0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative IS element transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539275.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112052.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39527">
        <property type="protein sequence ID" value="CAH39527"/>
        <property type="gene ID" value="BPSS2049"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2049"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5583"/>
    <dbReference type="eggNOG" id="COG3316">
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    </dbReference>
    <dbReference type="OMA" id="CHEIRHM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS240" evidence="2">
        <location>
            <begin position="74"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="28398" checksum="E1AB8CFF5B789507" modified="2004-10-25" version="1">MKPKALYHGHRFPAAIISQAVRWYFRFQLSLRDIEELLFERGVIVSYETIRRWCDKFGAAFARRVKAARRKPGRTWHLDEMFVNLRGEPWLLWRAVDEHGAELDILLQKRRDKAAAKRSFQRVLRSCPAPCNIVTDQLRSYPAAKAGIPELANVKHVFVKAAARVNNRAENSHQPTRERERRMRGFRDPKRTQAFLASFGPIRQHFALKRHLLRASLYRKHLAVRFSTWREFTEVTQNPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IQ4</accession>
    <name>Q63IQ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative inner membrane glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552148.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112018.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2015"/>
    <dbReference type="EnsemblBacteria" id="CAH39493">
        <property type="protein sequence ID" value="CAH39493"/>
        <property type="gene ID" value="BPSS2015"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2015"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5533"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFHRESG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266301" evidence="3">
        <location>
            <begin position="27"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="520" mass="56966" checksum="53F431282D9C8B00" modified="2004-10-25" version="1">MKSGRAMSLCVQCVLLLIVFACSLSARGTALGPASASLATAPFARTAQARAFAQPSLPHAEAVAFAFAQAEPFDAERPAAAGRPAAADAPPAPGKGIVISLCAAYLWVFALLTLVYASRHYVFGLDRLFKPQRAPYRAITHADWPEITVFVAAHNEEAVVADCLTALLATTYPRERLTIVPVNDRSTDNTRALIDEVQARAPELIKPFHRESGKPGKAAALKDALREIRGDIMVVFDADYLPRPGLLKELVAPFFDPEVGAVMGRVVPQNADRNLLARLLDLERAGGYQVNQQARNNLGLVPQYGGTVGGVRKSALDAVGGWRDDTLAEDTDMTYRLLLSNWRTVYLNHAECYEEVPERWPVRARQLTRWAKGHNQTLFRYLIPLLRSPVTPRRCRLDGALLLGVFVMPALLALAWGIALALYLTNGIDSLVLGLLVSVFALFAFSTFGNFGVFFEIVVAARLDGRATRLRLVPMNVVGFCVTIAAVVAALWGLALDALLRRELRWDKTERFRRPLNSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IR2</accession>
    <name>Q63IR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530208.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112010.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2006"/>
    <dbReference type="EnsemblBacteria" id="CAH39484">
        <property type="protein sequence ID" value="CAH39484"/>
        <property type="gene ID" value="BPSS2006"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2006"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5524"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="46" mass="4945" checksum="0E2126D44C7F641C" modified="2004-10-25" version="1">MNSSLRHCPLMDCNALPRGFDGATHRQMLDQHALDDGEHTGAVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IX9</accession>
    <name>Q63IX9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC transport system, exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524995.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111943.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1937"/>
    <dbReference type="EnsemblBacteria" id="CAH39415">
        <property type="protein sequence ID" value="CAH39415"/>
        <property type="gene ID" value="BPSS1937"/>
    </dbReference>
    <dbReference type="GeneID" id="56529644"/>
    <dbReference type="KEGG" id="bps:BPSS1937"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5424"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DVYMTVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="48"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="357" mass="38102" checksum="B68C8AA52487C32E" modified="2004-10-25" version="1">MIQVTRKQIVAAAAVVVVALGAYYGWTLLRHQGPGDGFASGNGRIEATEIDVATKLPGRIDAILVDEGDFVKAGQPLANMQIQVLRAQYDEATAQRQRALNTAAGVQSQVAQRKSDKAAAQAMVVLRESELDAAERRLARSQTLSREGASSLQELDDDRARARSAQAAVSAAAAQVAAAQAAIEATEAQLVAAHSAVTAADATVARVQADIDDSQLASPRDGRVQYRVAQPGEVLPAGGKVLNLVDLSDVYMTFFLPETVVGRVALGADARIILDAAPNYVIPATVSFVSSTAQFTPKTVETANERQKLMFRVKARIDRELLQKHLKLVKTGLPGVAWVRVDPSKPWPAQLMVKVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IZ7</accession>
    <name>Q63IZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187675.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111925.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39397">
        <property type="protein sequence ID" value="CAH39397"/>
        <property type="gene ID" value="BPSS1919"/>
    </dbReference>
    <dbReference type="GeneID" id="56596889"/>
    <dbReference type="KEGG" id="bps:BPSS1919"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5399"/>
    <dbReference type="eggNOG" id="ENOG50317C1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIHVFAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021945">
        <property type="entry name" value="DUF3562"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12085">
        <property type="entry name" value="DUF3562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="75" mass="8584" checksum="1B5AE1F5BEEB1690" modified="2004-10-25" version="1">MHQDTLFDSLLAAARRRSITEGEVMHMLDDEIARLADGARIHDYLRVIAIRRVRERIVSHARAADEAHARRPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IZ9</accession>
    <name>Q63IZ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative crp-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188531.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111923.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1917"/>
    <dbReference type="EnsemblBacteria" id="CAH39395">
        <property type="protein sequence ID" value="CAH39395"/>
        <property type="gene ID" value="BPSS1917"/>
    </dbReference>
    <dbReference type="GeneID" id="56596891"/>
    <dbReference type="KEGG" id="bps:BPSS1917"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5396"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SICRIHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="28974" checksum="819B83E7DB7364CF" modified="2004-10-25" version="1">MLTASVNEAEPCAEPQRPVIRLHPVTADDAPKLPATRCSTCAIRNVCMPAGLTPIEFARLDAMVCTTRHVKRGDALFRTHDTFQSIYAVRTGSFKTVVMHRDGREQVTGFQIVGETLGLDGVCGGRHNSDAIALEDSTVCIIPFAQLEAVCREVKPMQHHVHQLMSGEIVRESSLMMLLGTMTAEQRVAAFLLNISERFQKRGYSASEFNLRMTREEIGCYLGMKLETVSRMLSKFQRDRLIAPRGKQIRITDPQGLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J05</accession>
    <name>Q63J05_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111917.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1911"/>
    <dbReference type="EnsemblBacteria" id="CAH39389">
        <property type="protein sequence ID" value="CAH39389"/>
        <property type="gene ID" value="BPSS1911"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1911"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6259"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHPLFVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002860">
        <property type="entry name" value="BNR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02012">
        <property type="entry name" value="BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266075" evidence="1">
        <location>
            <begin position="44"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="238"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="494" mass="51843" checksum="A2F6D39750B20926" modified="2004-10-25" version="1">MDSAVAAAAHQGELSMRRNALPVSFVSGIAAAAALAMSAAAHGAPVLVSGPSPFAGCTIGGPGVNYVNAEVEPWVAVNPANPSNVIGAWQQDRWSNGGAHGLVAGYSFDGGLTWKQTNLPFSACAGGLAYERASDPWVSIGPDGTAYSVSISFNQSNNSNAVAASVSTDGGQTWSAPTLLIADNEPTTQFFNDKESVSANPTKAGTAYAVWDRLEQPTGNPHANLHTAASRGPSYFSKTVDGGKTWSAPSVIVDVPSRQQTIGNQIVVDRKTGTLYDFFDLIQPPFSAAAGKVAFIKSTDDGATWTKPQIVSGLQTVSVTDPNTNEPVRTGDIIPEPAIDPATGQLYVVWQDSRFNGGLYDEIALSTSSDGGATWSAPLRVNTPSGRPAFNPSVRVNSAGVVAVTYYDFRDLQPGNTTTLPTHYWRTLSSDGGRTFGTERRIAGPFDMRTAPVAEGFFIGDYAGLDTRGTSFLPFFVQTNSGNTANRTDVFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J07</accession>
    <name>Q63J07_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552078.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111915.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1909"/>
    <dbReference type="EnsemblBacteria" id="CAH39387">
        <property type="protein sequence ID" value="CAH39387"/>
        <property type="gene ID" value="BPSS1909"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1909"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5379"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CCADPDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="190" mass="20429" checksum="20374276C4831E5B" modified="2004-10-25" version="1">MNTALIGLDYIVDIMHPTGKIARSAAHGAQRDVVGRFNRALAAAKQKDWLRIGVKVGFEPGYADLPAHSPMFGRAQAFGALDLSGAGTAFHPDLDAAAFQLVVVKPRVSAFYATRLEAALRARRIERVIVAGVSTAWAVQAAARDAHDRDYEVLVLEDACAAATEDEHQRSIDTLRGIARIVTLDDLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JF1</accession>
    <name>Q63JF1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative osmotic adaptation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190814.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111771.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1765"/>
    <dbReference type="EnsemblBacteria" id="CAH39240">
        <property type="protein sequence ID" value="CAH39240"/>
        <property type="gene ID" value="BPSS1765"/>
    </dbReference>
    <dbReference type="GeneID" id="56598191"/>
    <dbReference type="KEGG" id="bps:BPSS1765"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5196"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIMVEWY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="368" mass="42636" checksum="14E085AEA80BED22" modified="2004-10-25" version="1">MSNLSDALQLKSAHSQLPVTAYFDEALLAREIETLFKKGPRYVGHELMVPEAGDYFALPSEDEGRVLVRNQASQIELLSNVCRHRQAIMLNGRGRTQNIVCPLHRWTYDLEGQLLGAPHFPDKPCLNLHATPLQHWQGLLFEAEGRDVAHDLAQLGTKHHFDFSDYLFDHVEIHECNYNWKTFIEVYLEDYHVVPFHPGLGSFVSCDDLKWEFGDWYSVQTVGVHNALAKPGSPTYQKWHDQVLRYRNGVPPEFGAIWMVYYPGLMIEWYPHVLVVSWLIPRGPQKTTNIVEFYYPEEIALFEREFVEAERAAYMETAIEDDEIAWRMDAGRRALMERGESQVGPYQSPMEDGMQHFHEFLRRQLGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JL8</accession>
    <name>Q63JL8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ordered locus">BPSS1699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528977.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111704.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1699"/>
    <dbReference type="EnsemblBacteria" id="CAH39172">
        <property type="protein sequence ID" value="CAH39172"/>
        <property type="gene ID" value="BPSS1699"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1699"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5111"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="56"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH39172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="397" mass="43191" checksum="9B21861E8D0A9168" modified="2004-10-25" version="1">MYNLPDDRGHFGPYGGVFVAETLIHALDELRAAYEKFKNDPEFVAEYNRELKHFVGRPSPIYHAQRWSETLGGAQIYLKREDLNHTGAHKVNNVIGQALLAKRMGKRRVIAETGAGQHGVATATICARFGMECVVYMGAEDVRRQAANVYRMKLLGATVVPVESGSRTLKDALNEAMRDWVTNIERTFYIIGTVAGPHPYPMMVRDFQRVIGDECKVQMPELAGRQPDAVIACVGGGSNAMGIFYPYIDDAAVQLIGVEAAGDGLDTGHHAASLIAGSPGVLHGNRTYLLQDDDGQIIETHSVSAGLDYPGVGPEHAWLKDSGRAQYVGITDEEALKAFHDCCRIEGIIPALESSHAIAYGVKLAPTLPKDKILLVNLSGRGDKDMHTVAERSGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K59</accession>
    <name>Q63K59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551877.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111513.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1506"/>
    <dbReference type="EnsemblBacteria" id="CAH38979">
        <property type="protein sequence ID" value="CAH38979"/>
        <property type="gene ID" value="BPSS1506"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1506"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5760"/>
    <dbReference type="eggNOG" id="ENOG502Z8GU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRWVETI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021927">
        <property type="entry name" value="DUF3540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12059">
        <property type="entry name" value="DUF3540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="250" mass="26296" checksum="EAE6964D9F9D4F34" modified="2004-10-25" version="1">MIHGSRTSMTPPPSSAPLGAAAPLPPVHARRADEAGAALRAARVTGRVGDWLLLDDHAGRARRADGCLLAPDIGDSVLIWTSAPAGALADDDDAAHAPSAYVLAVLARAGAPQAALALPGGVVLETGADGLRIDAPHIALAARERIDARAPRVDVSAHRAHVRAAHLDACARSIDGRAHDVRLVARRFTSTIGRALHTLGDCLRRVCGVDELHAARTRWRVDERAHLHARDVTLLADRHVGIDGERIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KL9</accession>
    <name>Q63KL9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCLP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184450.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111352.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1342"/>
    <dbReference type="EnsemblBacteria" id="CAH38813">
        <property type="protein sequence ID" value="CAH38813"/>
        <property type="gene ID" value="BPSS1342"/>
    </dbReference>
    <dbReference type="GeneID" id="56597545"/>
    <dbReference type="KEGG" id="bps:BPSS1342"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4643"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLVHLLQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCLP" evidence="1">
        <location>
            <begin position="58"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="310" mass="34241" checksum="734163C2A50848DA" modified="2004-10-25" version="1">MSTTVSAQTALGDNAARQLANATKTVPQLCTITPRWLTHLLQWVPVEAGIYRLNQVKNPEAVRAACTAREDEGALPRTFVPYEEEPREYFLSAVSTVLDVHTRISDLYSSPHDQIKEQLRLTIETIKELQESQLINHPDYGLLANVAEAQRVFPLTGAPTPDDLDELLTKVWKEPAFFLTHPLAIAAFGRECTRRGVPPPTVSLFGSQFLTWRGIPLIPSDKVPVADGKTKILLLRVGDKRQGVVGLYQPGIAGEQGPGLSVRFMGINNQAIASYLISLYCSLAVHSPDALAVLDDVEIGKYHDYPDTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS1</accession>
    <name>Q63KS1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205584.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111300.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38761">
        <property type="protein sequence ID" value="CAH38761"/>
        <property type="gene ID" value="BPSS1291"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1291"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4573"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPFWHGD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="271"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1599" mass="170889" checksum="88FA15A2FA15E83C" modified="2004-10-25" version="1">MHATPARPAAGALDAFHPVVAAWFSDTFAAPTGAQALAWPHIKAGRSTLVAAPTGSGKTLTAFLSALDDLVRDALAHDGALPDETLVVYVSPLKALSNDIHVNLEAPLAGIAAEIARRGLPVPQIRTAVRTGDTTQAERVAHRKHAPHILVTTPESLYVLLSSESGRRMLASTRTVIVDEIHALANAKRGSHLALSLERLDALVGRKLPRIGLSATQKPVEAVARFLVGGRDDAPLDCAIVDTGHTRTRDLALELPPVPLEPVMANDVWERLYDRIAELAAAHRTTLVFVNTRRMAERAARHLADRLGADAIAAHHGSLAKEHRFDAEQRLKHGKLKLLVATASLELGIDIGDVELVCQLGSPRGIAPFLQRVGRSGHHIGGVPKGRLFPLSRDELVECAALLDCVRRGELDVLRIPRAPLDVLAQQLVAEVACREWDEHALYRCVTQAAPYATLARETFDEVLKMLAEGFTSRRGARAAYLHRDVVAHTVRGRRGARLAAVTSGGTIPDNADYAVLLEPQGVNIGTVNEDFAVESLAGDVFQLGNQSYRIIRIETGRVRVEDAHGQAPNIPFWLGEAPARSDELSAGVARLRARLDALLAHGDAAGAGAALPVNAASAPAPEREAAAAGQGARARAAAPHGTPALARRALPAALPAAPPAVCARAAPSAAAPSAAAPSTAIPSAAAPTVAAMPVPPEAELRAEPRRLAPALAWLTGELGLDAEAARQIADYLARARAALGALPTQDTLVMERFFDESGGMQLVIHSPYGSRINRAWGLALRKRFCRSFNFELQAAATDDALILSLSHAHSFALDEVWRYLRASSAEHVLIQALLDAPLFAARWRWNATTSLALPRFAGGRKVAPQLQRMKSEDLLATVFPDQVACAENIVGEREVPKHPLVDQTLDDCLHDAMDTEGWLALLRRIEAGDVALVARDLPAPSPLAAEILNAKPYAFLDDAPLEERRTQAVLARRWSDPESADDLGALDAGAIEAVRDEAWPLVREPDEMHDALVGLACIADDEIASHDGWRACVAQLAAGGRAARLALAGGRGLWIAAERVACMRALYGADVALDPPLAPPPGFDAPWEPEAALVDVIRARLTGFGPLTAAALAAPLALPAASVAIALAALEREGYVMRGRFTPGARDDEWCERHLLARIHRYTVKRLRREIEPVELADFMRFLFHWQRVAPDTRGLGGDALAAVVHQLEGFEAAASAWEDEILPARLADYVAGGLDEPCRAGKLTWTRLGAPAKAASAPVKTTPVVLLPRRELAIWQALRDPAAQPALSARAERVRATLAAYGAMFFDELAAHARLLPVELERALGELVAAGLVNADSFAGLRALLRPAAQRPSRARRGGALIGGMDDAGRWALVQRLPLAPLDFGEGGSEDEAANDDDAPSGDGTPGAGPEAARRGGVREGGAEADARIARAMRAAPPQAGRHAIAPAALEHVARTLLRRYGVAFWRLLACEAEWMPSWRELLPVYRRLEARGEIRGGRFVAGLAGEQFALPDAIPILRELRRRPAEGLMLCVSGADPLNLTGTLLPGERVPALAGNRILFRDGVPIASLVGGQFAFARELDALAQDRARARLARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KV0</accession>
    <name>Q63KV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198085.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111271.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1264"/>
    <dbReference type="EnsemblBacteria" id="CAH38731">
        <property type="protein sequence ID" value="CAH38731"/>
        <property type="gene ID" value="BPSS1264"/>
    </dbReference>
    <dbReference type="GeneID" id="56597484"/>
    <dbReference type="KEGG" id="bps:BPSS1264"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4534"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRQFADN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="78"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="22874" checksum="F49D4015D9CC638C" modified="2004-10-25" version="1">MSDEIDGGIEQTAPIWAAFGDLMSVLLGAFVLILVGVIGVQLELSSKLDAEVRQRQLESQRRKTLEQALAAPLAAGRVTLVNGRIGISGSVLFALNSDELQPAGRDLLKSLAGPLAAYLNANHEILMVSGFADDLQVRAGNRRFADNWELSAKRALTVTRAFIDEGVPASSVFAAAFGSEQPVSPNSNDAGRAKNRRVEIAPVPRPTTGDGERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KZ1</accession>
    <name>Q63KZ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative efflux pump/antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528518.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111230.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1222"/>
    <dbReference type="EnsemblBacteria" id="CAH38689">
        <property type="protein sequence ID" value="CAH38689"/>
        <property type="gene ID" value="BPSS1222"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1222"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4465"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="6">
        <location>
            <begin position="438"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="583" mass="60812" checksum="C5BCCBB62D15AC23" modified="2004-10-25" version="1">MPHDVSLIALLAAGFGLAMIFGYLASLLKMPPLVGYLLAGIVMGPGTPGFVGDLALAQQLAEIGVMLLMFGVGLHFSLGDLLSVRKIALPGAIVQIAAATALGAGLALWWGWSVGGALVFGLSLSVASTVVLLRALEGRGLIESVNGRIAVGWLVVEDLVMVLVLVLLPPLAALLGGGGAPAHGDAAVHAGEAGGSLWAALGVTLLKVAAFVALMLVVGKRVFPRILWLVARTGSRELFTLCMIAAAVGVAFGAAKLFDVSFALGAFFAGMMMRESEFSRRAADETLPLRDAFSVLFFISVGMLFDPRVLIDEPLHVLEVAAIVVLGKTLAAVALVLAFRYPLNTALTVGVSLAQIGEFSFILASLGRGLGLLSAEGQSLILAVALLSIALNTLLFAAVDPVLAWIRKRSAFARRLESRDDPLAALPMSTPQAHLTGQVVIVGYGRVGTRIAHALDARGIAYVVVEQNRETVEKLRADGVAAVSGDAVEPIVLVQAHIARAGMLVVTLPDVFDVRQIVDISRTLNPAIEIALCTNSDEEAALLANEGMGEVFVSETELAHGMTEHVLARMGAGEAHARRSAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L28</accession>
    <name>Q63L28_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Acyl-homoserine-lactone synthase</fullName>
            <ecNumber evidence="2 7">2.3.1.184</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autoinducer synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:10096"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:55474"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.184"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the autoinducer synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.184" evidence="2 7"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528416.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111193.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1180"/>
    <dbReference type="EnsemblBacteria" id="CAH38648">
        <property type="protein sequence ID" value="CAH38648"/>
        <property type="gene ID" value="BPSS1180"/>
    </dbReference>
    <dbReference type="GeneID" id="56530406"/>
    <dbReference type="KEGG" id="bps:BPSS1180"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4412"/>
    <dbReference type="eggNOG" id="COG3916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YMLKDTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061579">
        <property type="term" value="F:N-acyl homoserine lactone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018311">
        <property type="entry name" value="Autoind_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001690">
        <property type="entry name" value="Autoind_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39322">
        <property type="entry name" value="PTHR39322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00765">
        <property type="entry name" value="Autoind_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01549">
        <property type="entry name" value="AUTOINDCRSYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00949">
        <property type="entry name" value="AUTOINDUCER_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51187">
        <property type="entry name" value="AUTOINDUCER_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="3 6 7" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="22396" checksum="9479D3129270D977" modified="2004-10-25" version="1">MIDTTVISAAQLDSTVKAALGNYRRAIFIEKLGWPLPLVDGLEIDQFDRPDTIYVVGKTESGDICGCARLLPTTRPYLLGEVFPDLMGDAAPPCSAHVWEISRFSSSILSGGPDALRQAHRNTRILLAKIVRFAQAAGVKRLITVSPLAVERLLNRLKVHIHRAGPPRLIDGKPVFACWIEVDDITLQALDIEPAADSAAGALRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L37</accession>
    <name>Q63L37_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative non-ribosomal peptide synthase/polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205553.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111184.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1171"/>
    <dbReference type="EnsemblBacteria" id="CAH38639">
        <property type="protein sequence ID" value="CAH38639"/>
        <property type="gene ID" value="BPSS1171"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1171"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4402"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HHIAVDD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="508"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1158" mass="124451" checksum="489C0164EE04E469" modified="2004-10-25" version="1">MTQSVFARFEQVCRSSAQAVALESAEHRLTYAQLHDRVASIGARLAAAGVTPGTLLGIFLPRDVRLPAALLASLGSGAVYVPLTEKYPPERLREIIETHGIEHVVTTEALASQLPASCGKIVLPAEGSETAGPRPAGERADWRPAGERAQNAPVYVVFTSGSTGTPKGVLIGERNLGNLIDWYAASFSAEQRRSVLASTQITFDLSVFELICTLCTGSKVVIVENVLQLLDEGAPCDVSLINTVPSAARELVRHRKFPAAARVVNLAGEALYQDLVDDIYEAAPQLEQVFNLYGPSEDTTYSTGHAVPRGGASRTVSIGRSLPGKRAHILSDALTPVAPGEVGEICLSGEGVALGYLNDATLTAEKFPTIGHGPLAGERVYRTGDLGSVDGDGLLRYLGRADRQVKVRGVRIEPGEVEVALRSIDGIADAAVVKIVDAANNDQLVALVVAQPSCPAEHAILDRLQALIPAFMVPSRVERIDAIPLNGNGKTDRTKLEQIAGALFGAAPPADDIQARVAQIVAKLMSRTDVAADADFFRIGGNSLLSAQLTFMLQKQFSVTLSIADVFRHRTIGALAAIIRERTHKAAQTAPAAAGQQPAAVRSTSGGAGAGQPVVFATPAQRGIWLLENSPGGRAVSNAPLVFEYAGTLERALLERCVTQLLERHAILRSNYVWEDGSLRIKCNAPVPFRVETVDLGSLAPDAQQAKARELVAREVMRPFDLRRDPMLRVTDIAFGERAGQLVFVFHHIAVDDRALNIVFSELQRLYAAGGDPAAIGAAPARQFADYAAASREASARLGEHLDYWRHKLADYRGATPYLVDPQAKPAARFAGRLHLHRVARHVSRQLDAAAARRGLTPFALFAAAVACIVHRASGSDDVTIGTFFSNRDHFQDNDLVGFFVNTLPLRVRIDAGWDVDQLAQAMSATLAQAHAHRDVTTEDVFDALQVNNALRRAAFRVMVNLEPEQAEVLTMGALSARRMLLDRHVAKYDLLFSLRKEDGDYRVLVEYNTELYDGDVMAGVCANLDRSLAALTGTASERLDAIALPDPLERGAPGDAAAGPADADAPAAAAADIDLREVVRDIWASEVGHRTFGDDDNFFDIGGSSLKIMTVYEKLSNFLKRHGIEKEIDIVDLFEHVSVAALTDFLGALIEHDAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LE9</accession>
    <name>Q63LE9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111072.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1061"/>
    <dbReference type="EnsemblBacteria" id="CAH38527">
        <property type="protein sequence ID" value="CAH38527"/>
        <property type="gene ID" value="BPSS1061"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1061"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5196"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EEMQMYL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="120" mass="12746" checksum="7035A12193AAA02F" modified="2004-10-25" version="1">MSMKISELAEFDGSKYLKDEATIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIMKVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LJ9</accession>
    <name>Q63LJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ionic antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111022.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38477">
        <property type="protein sequence ID" value="CAH38477"/>
        <property type="gene ID" value="BPSS1016"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1016"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5144"/>
    <dbReference type="eggNOG" id="COG0387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AAVMITC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="55"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="236"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="380" mass="39197" checksum="49D7EE004444F6E5" modified="2004-10-25" version="1">MPDRLLESLLAPCHDQGHSMPISSSALPRWTLVAPLAAWLVLALSRVVPAEGFAIAFVAAALAGAVFSAVHHAEVVAHRVGEPFGTLVLAIAVTVIEVALIVSVMLSAGPEKAGLARDTVFAAVMIVCNGIVGLCLLVGGWRHGEQDFQGRGATKALAVLASLSVLSLVMPNYLSAAPGPRLSTSQLAFAGVSSLVLYGVFVFVQTVRHRDYFLIDGSADESVHAVPPSGRTALTSIAFLFVSLVAVVLLAKLLSPAVERTVLRLGAPEAAVGIVIAALVLLPEGLAAVGAARANRLQTSMNLALGSALASIGLTIPTVAAVFIWTGAPLTLGIGAMETVLLSLTLLVSTLTLSLGRTTVLHGVVHLSLFAAYLFLSITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LV4</accession>
    <name>Q63LV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative surface-exposed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSS0908</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110917.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0908"/>
    <dbReference type="EnsemblBacteria" id="CAH38370">
        <property type="protein sequence ID" value="CAH38370"/>
        <property type="gene ID" value="BPSS0908"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0908"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7203"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GSAHIKT"/>
    <dbReference type="PHI-base" id="PHI:4669"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008640">
        <property type="entry name" value="Adhesin_Head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008635">
        <property type="entry name" value="Coiled_stalk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005594">
        <property type="entry name" value="YadA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03895">
        <property type="entry name" value="YadA_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05658">
        <property type="entry name" value="YadA_head"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05662">
        <property type="entry name" value="YadA_stalk"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266150" evidence="12">
        <location>
            <begin position="19"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="524"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="652"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_anchor" evidence="13">
        <location>
            <begin position="711"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH38370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="771" mass="73182" checksum="4694C94C3A8D6B7A" modified="2004-10-25" version="1">MSLAVSAAMGCMATDAAAQVSYAAGENAYAGPGGNTGPWAFYNPAFSAGTLLYGTAVGNYAYANGEGSSAYGDHATVKGRIGSAFGAYSEAAGDGSTAIGASARALPDFSIAIGTNAQALKDTGQSIPGREDIGTIAIGAGALAQGDNSDPLHVSAPNAFGGYSSATASGAVALGEGAASSGYYANALGSYSKASGAGAVAVGGGAQASAQGAVAIGGATSVDNATALSGYASASGVNAIAIGSGAQATGARSISIGTGNVVSGASSGAFGDPSTVTGTGSYSFGNNNTINSNNAFVLGNNVTIGPGFDGSVALGSGTTLAAANPTGSATITTSSGGQLTLSGFAGANPTSVVSVGAPGAERQITNVAAGRITPTSTDAVNGSQLYAVASTIDNAVNGGGIKYFHANSTLADSTAAGTDSVAVGPAALAYGNDSIAEGTNATAGVSGNPAVAGDVALGSGAQATGGRSLALGANASVNTAGGVALGAGSVANRAAGTYTDPITGSSFTTAFGAVSVGLEGSLRQITNVAAGTQATDAVNVGQLQGAIAQLNQTIQNITNGSNSGNTGNNGNNTGQTVSGQWITGNPSTYTPPVASGIGSTAAGSGSVASGANSVAIGDGASASGNNSVALGAHSVASAPNTVSVGSVGNERTISNVAPGVNGTDAVNVNQLNSGIGNAVGQANQYTDQKVDHLRREMNGGVAAAMAVAGLPQPTAPGKSMVAIAGSTWQGQQGFALGVSTISENGKWLYKGSLTTSTRGGTGAVLGAGYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LW9</accession>
    <name>Q63LW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939921.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110902.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0893"/>
    <dbReference type="EnsemblBacteria" id="CAH38355">
        <property type="protein sequence ID" value="CAH38355"/>
        <property type="gene ID" value="BPSS0893"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0893"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7186"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYLAMSW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266572" evidence="7">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="6"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="38205" checksum="1210E2C56DC5CB9D" modified="2004-10-25" version="1">MVKHAAATLLGALAVAGAWAQSSVTLYGSLDAGVAYVNNVGGGAKWSMIQGNTQPDRWGLKGVEDLGGGLKAIFQLENGFYTNNGQMAAAGTMWNRQAFVGLNSDRLGALTLGHQTPFNFDWLDPLSSAFLAQSWYAFHPGNLDQLADTSTVPFNNSVKYRSPAFAGFTVGAMLGFGNTTNFSTGRTMSFGVNYANGPFKAAAVYSNEHDQAFPMATVGGIAGPGGTFQGMPVASYVAKKAQNMGAGLSYRFGPLLVHGLYTRVKLQANGHSDTFQSYDAGANYQSSPFNVIAGGAATSTLAGRRWSQFELGDTYSLSKRTQLYVNVLYEHASGNAKAAFFTAGASSTANQVIVLTGIHHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M13</accession>
    <name>Q63M13_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HNS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110858.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0846"/>
    <dbReference type="EnsemblBacteria" id="CAH38309">
        <property type="protein sequence ID" value="CAH38309"/>
        <property type="gene ID" value="BPSS0846"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0846"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4942"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITTWFSI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="6">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="98" mass="11201" checksum="2ABE91D289856622" modified="2004-10-25" version="1">MVMATYKELLAQLDDLKQQAKRARALELPDVLVGLRKKIVEYGLSQKDLFPPRLGRPKKADALPKPRYRDPDTGATWTGRGRAPAWIAGQDRERFRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M46</accession>
    <name>Q63M46_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004205282.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110825.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63M46"/>
    <dbReference type="STRING" id="272560.BPSS0814"/>
    <dbReference type="EnsemblBacteria" id="CAH38276">
        <property type="protein sequence ID" value="CAH38276"/>
        <property type="gene ID" value="BPSS0814"/>
    </dbReference>
    <dbReference type="GeneID" id="56597136"/>
    <dbReference type="KEGG" id="bps:BPSS0814"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7083"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGDENIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="122" mass="13125" checksum="5B0149439CE59A66" modified="2004-10-25" version="1">MALPVLVVDDSTLARKLLIKSLPSDWDVEITQASNGAEALSHYRAGKGAVIFLDLTMPVMDGFQVLEHIREEGLDAFVIVVSADIQEGAVDRVKASGAIGFVAKPVSTERIVPILKGYGLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M84</accession>
    <name>Q63M84_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266264.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110787.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0778"/>
    <dbReference type="EnsemblBacteria" id="CAH38238">
        <property type="protein sequence ID" value="CAH38238"/>
        <property type="gene ID" value="BPSS0778"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0778"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4848"/>
    <dbReference type="eggNOG" id="COG5649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVPVWEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="16007" checksum="B36E6A7607B32407" modified="2004-10-25" version="1">MKDIDSPDDPPACVLIDRRIAELGDWRGDTLSRMRGLIRDADPDVVEEWKWRGTPVWSHDGIICTGESYRSVVKLTFAKGASLDDPAGLFNSSLDGQVRRAIDIREGETLDADAFKALVRAAIALNQSSGNARTQAKAKRAKPDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M89</accession>
    <name>Q63M89_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GerE family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523886.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110782.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0770"/>
    <dbReference type="EnsemblBacteria" id="CAH38231">
        <property type="protein sequence ID" value="CAH38231"/>
        <property type="gene ID" value="BPSS0770"/>
    </dbReference>
    <dbReference type="GeneID" id="56530778"/>
    <dbReference type="KEGG" id="bps:BPSS0770"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7015"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKKRLMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
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        <property type="entry name" value="GerE"/>
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    </dbReference>
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        <property type="entry name" value="Response_reg"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
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        <property type="entry name" value="HTH_LUXR"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="212" mass="23024" checksum="B2ACB3D7AF174675" modified="2004-10-25" version="1">MIRLLMVDRHAVLRDGLRHILEKSGEFEIDGEAADAASAFELAGRGCAEIALLDQTTLGRECAELIRRLRRAAPSTRILVLAARASQRHAAAAFQAGASGYLTKQSGCEELLAALRKIAAGGVYVSMHVAEQFAENLHSPSDAPPHERLSRREFEVFRRLAAGDTPADIAQALGISAKTVRIYKAHVLDKLELPNETALVRYAVAHRIGDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M90</accession>
    <name>Q63M90_BURPS</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38230.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M93</accession>
    <name>Q63M93_BURPS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
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                <person name="Simmonds M."/>
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                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
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            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="CAH38227"/>
        <property type="gene ID" value="BPSS0767"/>
    </dbReference>
    <dbReference type="GeneID" id="56530782"/>
    <dbReference type="KEGG" id="bps:BPSS0767"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7010"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF141086"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="11689" checksum="6DAD0A1392F34E67" modified="2004-10-25" version="1">MTQKFVGTHVVGPREKLPSGKPWINAPLTVKVPFPAAFNAIPIVVASALQDPKHTSTYPDTFAVTVISVTKTDFTVNICRADYVRDNYTTSGWGQNLHLSYIAETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS2</accession>
    <name>Q63MS2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="7" type="ordered locus">BPSS0576</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Betaproteobacteria</taxon>
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            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0576"/>
    <dbReference type="EnsemblBacteria" id="CAH38033">
        <property type="protein sequence ID" value="CAH38033"/>
        <property type="gene ID" value="BPSS0576"/>
    </dbReference>
    <dbReference type="GeneID" id="56530973"/>
    <dbReference type="KEGG" id="bps:BPSS0576"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6749"/>
    <dbReference type="eggNOG" id="COG0559">
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="308" mass="32275" checksum="A8D331EA259B9F65" modified="2004-10-25" version="1">MNDFFPQFAQQLVNGLTLGAIYALIAIGYSMVYGIIGMINFAHGEIYMLGAYVGLVTLTAIGTSAGYPLPVVLGAALVVSVVVTGLYGFAVERVAYRPLRGGPRLVPLISAIGMSIFLQNYVQIGQGARDMSVPVLISGAFDIHLGGDFDVTVPYARLLIVCVTIVLMIALTLFIAHSRMGRACRACAEDMRMANLLGIDTNRVISFTFVLGAMLAAVGGVLIGLTIGKLNPYIGFVAGIKAFTAAVLGGIGSIPGAMLGGVLLGLAETFASGYMPAEYKDVVAFGLLVLILLFRPTGLLGKSDIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MU3</accession>
    <name>Q63MU3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ferredoxin oxidoreductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543120.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110576.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0555"/>
    <dbReference type="EnsemblBacteria" id="CAH38012">
        <property type="protein sequence ID" value="CAH38012"/>
        <property type="gene ID" value="BPSS0555"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0555"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6723"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQVHHIH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="297"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="381" mass="42200" checksum="E27EBBFE67DA7133" modified="2004-10-25" version="1">MMRDAANFEPADSRVTRPAFWQALPERWTSDVEETLVCCHVRQETHDVKSFFFRSPQGRAFSFEPGQFVTLELDIDGETINRCYTISSSPARPHTISITVKRVPGGKVSNWLHDNLQPGAPLRVLGPAGEFTCARHPARKYLFLSAGSGITPLMSMSRAHHDLAEDRDIVFVHSARTPDDIIFARELDLIASTHANFRTAFVCERLGARTNWHGVTGFLSLPLLKLVAPDFMEREIFTCGPAPYMKAVRELLAEAGFDRSRYHEESFSFETLAQREAPADAPAGEDAAARGAQVRQYTIAFAKSHREIACGADQHVLDAARRAGVRLPASCTQGMCGTCKVKLVSGQVDMKHNGGIRQREIDQGMVLLCCSKPLSDLVVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N98</accession>
    <name>Q63N98_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552390.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110421.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0398"/>
    <dbReference type="EnsemblBacteria" id="CAH37851">
        <property type="protein sequence ID" value="CAH37851"/>
        <property type="gene ID" value="BPSS0398"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0398"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4390"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="73" mass="8091" checksum="4C4283B9501F91A9" modified="2004-10-25" version="1">MMDKQTVLEACNRVADVADLPFYAELVDALRGAMVALTASEPTMKHYPEAVARHEKAIRDAKSCIKRIDQDAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NC4</accession>
    <name>ACSA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="1">AcCoA synthetase</shortName>
            <shortName evidence="1">Acs</shortName>
            <ecNumber evidence="1">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acsA</name>
        <name type="ordered locus">BPSS0375</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188376.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110395.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63NC4"/>
    <dbReference type="SMR" id="Q63NC4"/>
    <dbReference type="STRING" id="272560.BPSS0375"/>
    <dbReference type="EnsemblBacteria" id="CAH37823">
        <property type="protein sequence ID" value="CAH37823"/>
        <property type="gene ID" value="BPSS0375"/>
    </dbReference>
    <dbReference type="GeneID" id="56597027"/>
    <dbReference type="KEGG" id="bps:BPSS0375"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6501"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000065284" description="Acetyl-coenzyme A synthetase">
        <location>
            <begin position="1"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="397"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="421"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <sequence length="660" mass="72282" checksum="B067B10A94777DF9" modified="2004-10-25" version="1">MSAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKPFGKVLDETNAPFYKWFEDGELNASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACARIGATHSVVFGGFSSKSLHERIVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRDVWMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFDWKPDDVFWCTADIGWVTGHSYITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPINPEAWIWYHKNVGQARCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWPAMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NI7</accession>
    <name>Q63NI7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LuxR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205386.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110332.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0312"/>
    <dbReference type="EnsemblBacteria" id="CAH37760">
        <property type="protein sequence ID" value="CAH37760"/>
        <property type="gene ID" value="BPSS0312"/>
    </dbReference>
    <dbReference type="GeneID" id="56597798"/>
    <dbReference type="KEGG" id="bps:BPSS0312"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4298"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RESLQWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005143">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036693">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03472">
        <property type="entry name" value="Autoind_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75516">
        <property type="entry name" value="SSF75516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="26235" checksum="23ADEB71BF577403" modified="2004-10-25" version="1">MSIGSFNEILNATCKKSLFEQTAYHVRQLGFKNFAYRHQISGAASSRCMLDGFPAEWRLRYDAADYLSIDPVVQHCRCRTVPLIWHDDLYTTSRAKLMRDEAKSYGLVYGLSCPVHDRSGAISMLSMATDDPFEHDASDILRLLSLSQLLASFVHAAMHELLDCRLRRQGSCDLTARERESLQWAGRGKTAWEISKILGISERTVVFHLSNAARKIGANNRAQAVVIASARGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NW7</accession>
    <name>Q63NW7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549277.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110202.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0181"/>
    <dbReference type="EnsemblBacteria" id="CAH37626">
        <property type="protein sequence ID" value="CAH37626"/>
        <property type="gene ID" value="BPSS0181"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0181"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6243"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIARPHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="3">
        <location>
            <begin position="417"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="775" mass="84678" checksum="D305651F74C405B5" modified="2004-10-25" version="1">MPNFSAARTVTVSGPAVPTTPVGEPALELSAIRGDETLSQIYSYTLDCLTPPDPLLAHERAANLDLKAMIGKALTVTVQLEGMGSFVPGMPGMAGAANIGAGAREISGIVTGARFEGQLNRQCRYRLTMRPWIYLADLRSDYRIFQNRSVDEIVDEVLNAYSYSYDKRLSGRYPKLGYQVQYGETDFAFIQRLMQEHGIYWFFEHTNQVHRMVLVDHLGAHKPVESAAYRTLRYYPPGHKIDAEYIDRFSTEEHIRPGRWATGDFDFEKPNADLGVENALPRDTAHNGLERYEWPGDYTAREHGEHLARVRMEQTRARGERASGGGNVRDIVCGTTFALAGHPHASANREYLVIGATFEATETGGASGPGAYRIDTSFVAQPATTAFRPPRTVRKPRTRGPQTAIVTGPRGQDIWTDQYGRVKLKFHWDRSLVDDQNSSCWVRVSYAWSGNNYGGVNIPRVGSEVVVDFEHGDPDRPLVTGQVYNALHMPPWPLPENATQSGFMTRSPAGGGENANMLRFEDKAGEEQVKLHAERNYDVSVERDATTAVGRKHLTLVGVDLMPVMSTRSPLERLIDLLRTGGAASPAASGQPAAASRQPSGQQQQHQQQHQQHQRQRQPYQQLKQQRQMQRAGGWQALAANVAKTLQEIVAVLTDPFVTASVSTVQGASTSVVFGDAKGVHVGDTVKITSGDAHSEVNGTASSKDVNSVSLKGTSTSLTGVSTSETGTNIVTTGLTVSTTGASVSTTGFSATETLVQVAKKTQECEFIKGIKISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NY0</accession>
    <name>Q63NY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529718.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110189.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0168"/>
    <dbReference type="EnsemblBacteria" id="CAH37613">
        <property type="protein sequence ID" value="CAH37613"/>
        <property type="gene ID" value="BPSS0168"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0168"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6230"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGWFKYE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017733">
        <property type="entry name" value="OmpA/MotB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03350">
        <property type="entry name" value="type_VI_ompA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="303"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="421" mass="45926" checksum="D1C7060CE4E72A3B" modified="2004-10-25" version="1">MHHPDISAPAPTFDSVAATFARREPAPAPAGEPPAARLAAIRLARNPLLEAARVLLRALADMPERLDRDDIPQLRLLLEQEVRLFQRLCEQANIRRDHMLGARYCLCTALDEAAMQTSWAQSASGNLGTWISEGLATSFHEDRQGGDKVYLLIGRLMNSPHEHIDLLEVIYRILSLGFEGRYRYEADGQRKHETVRQRLYNEIASQRGPVSVALSPHWQPGPRSRSAPFRDFPAWVTAAVLSLIALGLFGCFKYALSTRSADVQQRIAAIARMAPPAAPAELRLATLLAGEIAAGTLSVEENARRSSVTFRGDAMFAPGAAGVNPAMGPLIRKIAAEIAKVPGKVTVRGYTDNQPIKSRQFASNEALSEERATQVMQMLQSAGVPASRLEALGKGGAEPIGDNRTPQGRALNRRVEITVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P52</accession>
    <name>Q63P52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbria subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529637.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110117.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0094"/>
    <dbReference type="EnsemblBacteria" id="CAH37540">
        <property type="protein sequence ID" value="CAH37540"/>
        <property type="gene ID" value="BPSS0094"/>
    </dbReference>
    <dbReference type="GeneID" id="56531458"/>
    <dbReference type="KEGG" id="bps:BPSS0094"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6122"/>
    <dbReference type="eggNOG" id="COG3539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYYAEDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267027" evidence="1">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrial" evidence="2">
        <location>
            <begin position="43"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="190" mass="19738" checksum="EBE3A0542C9D7347" modified="2004-10-25" version="1">MIEMNGLKFRRGAARRWPSIAAAAMFAASAACGAPPSPTVTIKFKGSYNPVTCTVVEGNENKTVHLPTISTSSLANAGETAGATGFDISVLCDGYAGNVLAYFENGPTTNENGNLDVEDPSDGQSASGVQVQLLNGDGSPIKVGDISTMKTVSVEASTPTPIPFFARYYATGKSGAGKVRTYVTFVIQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P61</accession>
    <name>Q63P61_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110108.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0085"/>
    <dbReference type="EnsemblBacteria" id="CAH37531">
        <property type="protein sequence ID" value="CAH37531"/>
        <property type="gene ID" value="BPSS0085"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0085"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4003"/>
    <dbReference type="eggNOG" id="COG5488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FACAIGE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019253">
        <property type="entry name" value="DUF2244_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10003">
        <property type="entry name" value="DUF2244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="22983" checksum="13E6F381625B7809" modified="2004-10-25" version="1">MKADARCDTRKHAQRHCTHAFVAHDPRLMTRDVAENRRVWLLKRNCALSPRQSLISMGLLAALTLAIAMPFAIAGAWAVFACAIGEIAAMCGCFLRYVRHAVDYDCVALTEQRLEVIQCDGAQLRRYDWNPLWVAVDLDAAHARDPTIRIRHGSETVLVGRHVTLARRRHVAGELNAALAASAGDFGDTDFAPSVRQRQPEPLAAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PL8</accession>
    <name>Q63PL8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109951.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3356"/>
    <dbReference type="EnsemblBacteria" id="CAH37369">
        <property type="protein sequence ID" value="CAH37369"/>
        <property type="gene ID" value="BPSL3356"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3356"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3812"/>
    <dbReference type="eggNOG" id="ENOG502ZAKB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYAFTHW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="28612" checksum="B55CCCC227E0A421" modified="2004-10-25" version="1">MARRSDSMPLLPDAPAMLALKLTLVPLFLLLVSIAGRRWGPSIAGWLAGLPVVAGPILFLVAVERGPAFGAHAALLSLSAIAASEAFSFAYAWTCRRHRWPLALALAAGLAAWAAAASALARLPATPPAATAVAFAATCFGQSCLPRGATLAPRAPLSHADLAGRLAAGAALALAVTSLAGALGPAWSGLLAVFPLLGSVLAVSSHRAHGPDFVVPLLRGMVFGRFSFAAFCLCVALTLPRQPALQAFAEAAALSVAVQGATKRLAARGPRPTALAQTATPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q50</accession>
    <name>CYAY_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iron-sulfur cluster assembly protein CyaY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cyaY</name>
        <name type="ordered locus">BPSL3175</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196764.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109768.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q50"/>
    <dbReference type="SMR" id="Q63Q50"/>
    <dbReference type="STRING" id="272560.BPSL3175"/>
    <dbReference type="EnsemblBacteria" id="CAH37185">
        <property type="protein sequence ID" value="CAH37185"/>
        <property type="gene ID" value="BPSL3175"/>
    </dbReference>
    <dbReference type="GeneID" id="56594186"/>
    <dbReference type="KEGG" id="bps:BPSL3175"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2064"/>
    <dbReference type="eggNOG" id="COG1965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EPMHEIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00142">
        <property type="entry name" value="CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="SSF55387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000193934" description="Iron-sulfur cluster assembly protein CyaY">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00142"/>
        </source>
    </evidence>
    <sequence length="108" mass="11677" checksum="DF2C81D3B78210F3" modified="2004-10-25" version="1">MSDTDYLTRAEAVLAAVERSVDAANDGDADIDLERNGSVLTLTFENGSKIIVNLQPPMKEVWIAAKAGGFHYRFVDGAWRDTRSGDEFFAALTGYATQQAGMPIAFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI2</accession>
    <name>Q63QI2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phenylacetic acid degradation oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">paaZ</name>
        <name evidence="3" type="ordered locus">BPSL3041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549951.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109636.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3041"/>
    <dbReference type="EnsemblBacteria" id="CAH37052">
        <property type="protein sequence ID" value="CAH37052"/>
        <property type="gene ID" value="BPSL3041"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3041"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2226"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CNTFPTW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="90"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="568" mass="60605" checksum="F662F9AC0E6AF9F1" modified="2004-10-25" version="1">MTHPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKAQLDKPFELDQPASGGTVGAERSPYGFALGVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAWQELQRIPAEAHWEKPQGKNPPLAMRKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLAITVRIARDVLREAGFDPNIVTLLATEGNDGALVQDLARRPEIKLIDFTGSSQNGTWLERNAYQAQVYTEKAGVNQIVIDSVDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAEGHVGFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAARIDEARKLGRILADSQALEHPAFKDARVRTPLVLQLDVADRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTLSVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAAFVANRFRVVQSRHHVAPKAAPAEAGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV3</accession>
    <name>Q63QV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamate/aspartate transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gltL</name>
        <name evidence="10" type="ordered locus">BPSL2921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194225.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109515.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2921"/>
    <dbReference type="EnsemblBacteria" id="CAH36931">
        <property type="protein sequence ID" value="CAH36931"/>
        <property type="gene ID" value="BPSL2921"/>
    </dbReference>
    <dbReference type="GeneID" id="56593758"/>
    <dbReference type="KEGG" id="bps:BPSL2921"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2362"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CSQIGMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="26685" checksum="988570034DA8F008" modified="2004-10-25" version="1">MISIKNVSKWYGQFQVLTDCTTEVKKGEVVVVCGPSGSGKSTLIKTVNGLEPFQQGEILVNGQSVGDKKTNLSKLRSKVGMVFQHFELFPHLSITENLTLAQIKVLGRGKDEATEKGMKLLDRVGLKAHAHKYPGQLSGGQQQRVAIARALSMDPIAMLFDEPTSALDPEMINEVLDVMVELAQEGMTMMVVTHEMGFAKKVAHRVIFMDKGLIVEDDRKEEFFANPKSDRAKDFLAKILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU9</accession>
    <name>Q63RU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547727.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109168.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2571"/>
    <dbReference type="EnsemblBacteria" id="CAH36579">
        <property type="protein sequence ID" value="CAH36579"/>
        <property type="gene ID" value="BPSL2571"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2571"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2792"/>
    <dbReference type="OMA" id="NTHFATH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="102" mass="11843" checksum="6E65264B21C35E92" modified="2004-10-25" version="1">MKPASEVFIAGPNERVDRFVEERLQQIDVTLSPLERRAVLKFAPYFRWATDDELRELLQRLKRHADGQIYANDSAPIDGRRKNRGPSECNTHFATHTYRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW1</accession>
    <name>Q63RW1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194869.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109156.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2559"/>
    <dbReference type="EnsemblBacteria" id="CAH36567">
        <property type="protein sequence ID" value="CAH36567"/>
        <property type="gene ID" value="BPSL2559"/>
    </dbReference>
    <dbReference type="GeneID" id="56528624"/>
    <dbReference type="KEGG" id="bps:BPSL2559"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2805"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRTWGAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267091" evidence="7">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="8"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="379" mass="40297" checksum="91DAC6100308C324" modified="2004-10-25" version="1">MKKTLIVAALSGVFATAAHAQSSVTLYGLIDAGITYTNNQGGHSAWSQSTGSVNGSRWGLRGAEDLGGGLKAIFVLENGFGINNGTLKQNGREFGRQAFVGLSHEQYGALTLGRQYDSVVDYLGPLSLTGTQFGGTQFAHPFDNDNLNNSFRINNAVKYTSVNWAGLKFGALYGFSNNNQFANNRAYSAGVSYSYAGFNIGAGYLQLNNNFGPTVSNASGAVALDNTFVGKRQRVFGGGLNYTFGPATAGFVFTQSRVNRATAIGAGASGVSSGIALDGTFMRFNNYEVNARYAITPAWTVAGSYTYTAGFIENHHPGWNQFNLQTAYALSKRTDVYLQGVYQKVNNDGTGLGAYINGIGGMSSTEKQIAVTAGLRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RY8</accession>
    <name>Q63RY8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2533"/>
    <dbReference type="EnsemblBacteria" id="CAH36540">
        <property type="protein sequence ID" value="CAH36540"/>
        <property type="gene ID" value="BPSL2533"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2533"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWRLQTV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="436" mass="46612" checksum="1B504B169E34C38F" modified="2004-10-25" version="1">MALAALGDTDAAIAHFRAAIAAEPHFVAAHFNLGNALDAIGQHAQAQHAFEAALALQPRFALALFGLANTLAARGRHRDALPHYEHAVGLDPSFVLAWLNLGTAHHALGAHEMALRAFDQALRLDPSLTLAQMHRAVTLLTLRDFARGLPAYEARHALPGAAPLGPLPRWQGEPIANRTLLVRAEQGFGDTLQFVRLVPLARARCARLILQVQPALLPLIAPMAARWRVSVVSADAARTPAADLVCPLLSLPFALGLEYDAIPSGTPYLDVPDAARRRFRGSLGGQAKRKFGIAWSGSAPVQDNRALPLDALAPLFALAGIDWIVLQPTLSDSERAALDAHPDAARIHRLDGLTDFAATAALVDRLDGVVAIDTAVAHLAGALGKPLWLMLPVAADWRWSTGDDSAWYPRARLVRQSEPGRWDDVVATVAGEIAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S96</accession>
    <name>Q63S96_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease 3</fullName>
            <ecNumber evidence="7">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribonuclease III</fullName>
            <shortName evidence="7">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">rnc</name>
        <name evidence="12" type="ordered locus">BPSL2429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938303.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109021.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2429"/>
    <dbReference type="EnsemblBacteria" id="CAH36432">
        <property type="protein sequence ID" value="CAH36432"/>
        <property type="gene ID" value="BPSL2429"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2429"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2961"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMARPMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="467" mass="49610" checksum="D86ED4AD0B7A1098" modified="2004-10-25" version="1">MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVTAVAPMLAAKPKRSKSARGAKHVEPEIVPGVKGVQEALDLRSPERKERGANRVAGGEAKGVESKAVDAKHGESRAAQLRADDAKAGETKAGEARASADAKAGAHTHAAAMPAVPEQADDAARSPATTPVAVIRAAHVEHSLDKGEPRASKPAEKPAAATDKPPEKASDKPSPEKTSEKTPDKSHEKQLDKSSEPVAEKALDKTADKPDAAARLPAETADRPPRARDASSSAEPDLAAAPVRVADAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SA9</accession>
    <name>Q63SA9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550146.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109007.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36418">
        <property type="protein sequence ID" value="CAH36418"/>
        <property type="gene ID" value="BPSL2415"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2415"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2978"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVEQDCV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="18468" checksum="DFFB47A6568BB2EC" modified="2004-10-25" version="1">MSTFTTAASPIPAAAPSAPLEWRWKPFGALTPDEIYAILSARSDVFVVEQNCVYRDIDHADFDAWHLGAYDAQGRLACYLRVLLPDASEPDIRIGRVLTVRAFRAMGLGNAMLTVALERIRAQWPDTPISLHAQAHLQKFYGAFGFAPSSDVHDEDGIAHVWMRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SF0</accession>
    <name>Q63SF0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NifU_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108966.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2373"/>
    <dbReference type="EnsemblBacteria" id="CAH36375">
        <property type="protein sequence ID" value="CAH36375"/>
        <property type="gene ID" value="BPSL2373"/>
    </dbReference>
    <dbReference type="GeneID" id="56596281"/>
    <dbReference type="KEGG" id="bps:BPSL2373"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3034"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IWLKMDG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17697" checksum="9D42ECADAC4C2F7A" modified="2004-10-25" version="1">MNPIESPAVAADAQSTLYQELIVEHKRAPRRFGKLAEPTHEARGHNPQCGDDLKVQLRIEGGRIGDIRFDGHGCAICIASASMMTEAVIGRDVDAARALQQRFRAVLTGQAEHDEAYLGKLSSLVAVRRYPSRIKCALLGWHALAHALDTRVAAPGETEPHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SK6</accession>
    <name>Q63SK6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192421.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108910.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2314"/>
    <dbReference type="EnsemblBacteria" id="CAH36317">
        <property type="protein sequence ID" value="CAH36317"/>
        <property type="gene ID" value="BPSL2314"/>
    </dbReference>
    <dbReference type="GeneID" id="56596112"/>
    <dbReference type="KEGG" id="bps:BPSL2314"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3110"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LDKYATH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="24921" checksum="884FA6C306B6FA16" modified="2004-10-25" version="1">MTIRVLLIDDHTLFRSGVKLLLQRQPDFEVVDEASDGVEGVKRAKQHQPDVILLDLNMPGLSGLETLQLLVQDVPSAHVVILTVSEDAEELTTALRDGACGFLVKNIDAETLVAGIRKAAAGEPVIAESMTAKWIASLRAPVPAARPAPAAALAPAAHASVDPDQLTPREHDIVRALARGASNKEIAREFDVAESTVKIHVQNVLKKLNLSSRVQIAVYAVERGLTAPHPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T51</accession>
    <name>Q63T51_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-05" db="PDB data bank">
            <title>Crystal structure of a Polysaccharide deacetylase family protein from Burkholderia pseudomallei.</title>
            <authorList>
                <consortium name="Seattle Structural Genomics Center for Infectious Disease (SSGCID)"/>
                <person name="Gardberg A."/>
                <person name="Edwards T."/>
                <person name="Sankaran B."/>
                <person name="Staker B."/>
                <person name="Stewart L."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521217.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108715.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3S6O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B/C/D=1-317"/>
    </dbReference>
    <dbReference type="PDBsum" id="3S6O"/>
    <dbReference type="SMR" id="Q63T51"/>
    <dbReference type="STRING" id="272560.BPSL2118"/>
    <dbReference type="EnsemblBacteria" id="CAH36121">
        <property type="protein sequence ID" value="CAH36121"/>
        <property type="gene ID" value="BPSL2118"/>
    </dbReference>
    <dbReference type="GeneID" id="56529078"/>
    <dbReference type="KEGG" id="bps:BPSL2118"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3349"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DDLPYWE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10977">
        <property type="entry name" value="CE4_PuuE_SpCDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017625">
        <property type="entry name" value="PuuE/SpCDA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03212">
        <property type="entry name" value="uraD_N-term-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="70"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3S6O"/>
        </source>
    </evidence>
    <sequence length="317" mass="36672" checksum="B064BD5CBC18191B" modified="2004-10-25" version="1">MAFDPNYPRDLIGYGRHPVQANWPGRARVAVQFVLNYEEGGENCVLHGDPASEQFLSEIVGAAAYPARHMSMESIYEYGSRAGVWRILREFDKRGLPLTVFGVGMAIERHPELARAFVELGHEIACHGWRWIHYQDMTPEREAEHMRLGMEAIERVTGVRPLGWYTGRDSPNTHRLVAEYGGFLYDSDHYGDDLPFWMDVEVSGGASVPQLIVPYTLDANDMRFATPQGFNTADHFFHYLRDAFDVLYEEGDEAPKMMSIGMHCRLLGRPGRFRALQRFLDHIERHDRVWVARRVEIARHWREHHPYRPHARREGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TB9</accession>
    <name>Q63TB9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL2048A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205115.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108647.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2048A"/>
    <dbReference type="EnsemblBacteria" id="CAH36049">
        <property type="protein sequence ID" value="CAH36049"/>
        <property type="gene ID" value="BPSL2048A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2048A"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.32"/>
    <dbReference type="eggNOG" id="ENOG5032WTF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MICCASA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021733">
        <property type="entry name" value="DUF3304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11745">
        <property type="entry name" value="DUF3304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="19800" checksum="EAF137713F72394B" modified="2004-10-25" version="1">MRGLALLGSVAACSRAVSEVSPQAGAKGAAVSQAGDDTMSLKLNALNDTDVPIGAFYVDGTWGSTVASRIGSGGGQMICCASAPGKWHPGLTVTLRWQDDTLYKKDPDAMASRVVSVGKHEHFSDGFLWVLFFPNDRIKVYASQWMPGFPGFPEGLQTPDSPCPEHFTRLSDDPRCSQPGKRIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TD8</accession>
    <name>Q63TD8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526781.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108628.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2031"/>
    <dbReference type="EnsemblBacteria" id="CAH36030">
        <property type="protein sequence ID" value="CAH36030"/>
        <property type="gene ID" value="BPSL2031"/>
    </dbReference>
    <dbReference type="GeneID" id="56526396"/>
    <dbReference type="KEGG" id="bps:BPSL2031"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.8"/>
    <dbReference type="eggNOG" id="COG5430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMHKREV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007893">
        <property type="entry name" value="Spore_coat_U"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05229">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00972">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266303" evidence="1">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SCPU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="181" mass="19108" checksum="8D364F2E669542F1" modified="2004-10-25" version="1">MHKREVQVVSGAAFMLFFAAASAGQLTGTMQVNLQVSRGCEVAGVAASGDLGRLDFGAQGPLWSDYLTADGRATSSGAVRVVCSPDVNGFLVSIDGGRNGDQSTRYLVKRGANGRVAGRIPYNVYRDAARSVPYVPLMPQSFLVDGGRDDVTLPVYGVVNGMTRAVPSGTYEDLLGITLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TE1</accession>
    <name>Q63TE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbriae-assembly chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526784.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108625.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2028"/>
    <dbReference type="EnsemblBacteria" id="CAH36027">
        <property type="protein sequence ID" value="CAH36027"/>
        <property type="gene ID" value="BPSL2028"/>
    </dbReference>
    <dbReference type="GeneID" id="56526393"/>
    <dbReference type="KEGG" id="bps:BPSL2028"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVFAWRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266764" evidence="1">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="2">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="30254" checksum="2C6C797306E5A3EB" modified="2004-10-25" version="1">MKVSRSPGAPARAARALRCALLGAAAAAPFVAQHAHAAASVMIWPIDPVIESGDRAAALWLENRDRRPVTLQVRVLGWREANGEDVYDEDQPRVAGSPPMATVEPGKRQLIRLTRLADTAPGTEQAYRVLIDEIPQPDDDAQPAASGTSLGVKFQMHYSVPLFVYGDGLWTKEHPDRRRDPATAGRPALRWRVEHDGGKRWLVVSNRGPVHARITHAAFEASGARADFARGLLGYVLPGARMRWALPETLKLHSNSKLIATVNGVADLAIDVDGAASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TE2</accession>
    <name>Q63TE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbriae-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108624.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2027"/>
    <dbReference type="EnsemblBacteria" id="CAH36026">
        <property type="protein sequence ID" value="CAH36026"/>
        <property type="gene ID" value="BPSL2027"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2027"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2287"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFNYDLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025949">
        <property type="entry name" value="PapC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043142">
        <property type="entry name" value="PapC-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13953">
        <property type="entry name" value="PapC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PapC_C" evidence="1">
        <location>
            <begin position="705"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="782" mass="83649" checksum="976494F423DB3172" modified="2004-10-25" version="1">MGIAFAAAGHARAGETATLADSFGRAPPPVGGTAAHGTLYLELVVNALSTGRIVPVRYRDGIYYARAGDLAQASVRTGAQPDALVDLSRLDGVQVEYESAEQRLKLTVPPDWLPRQTLGSPRLYDRTPAAVSFGLLFNYDVYANSPTLGTSYTSAWTEQRLFDRWGTVTNTGVYRRDYGGGAGGVGSNRYLRYDTFWRYSDQDRLRTYTAGDVITGALSWSSAVRLGGVSVERDFKVRPDIVTYPLPQFSGQAAVPTAVDLFINGSKTTTGQVNPGPFTMNNVPFINGAGEATVVTTDALGRQVATTIPFYVANTLLQKGLSDYSLSAGAMRRDYGIRSFSYGKFAASGTARHGLTDYLTLEGHVEGGERFALGGLGFDLGIGMFGVLGVAATQSRLAGASGRQYAFGYSYASQRFSVSLQRIQRTNGFRDLSVYDLPANVAYRLVRSSTQATGALNLGALGGTLGAGYFDVRGADGTRTRIANLSYTRPLWRRATLYASVNKTVGEHGVAAQLQLIVPLGEPGVVTGALARDANNSFSERVQYSRSVPSDGGLGWNLAYAGGGSHYQQADATWRNRYFQAQGGVYGYGAGRGYARWGEVQGSVVVMDGAVLPANRVDDAFVLIDTQGRGGVPVRYENQLVGKTDGGGHLLVPWAPSYYAGKYEIDPLDLPSNVRVPIVERRVAVRDHGGALVTFPIRRIVCAQIALVDAAGRPVAIGSRVLHEESGETALVGWQGETYLEGLSALNHLRVRTPDGRTCRATFAADIDAAQMSRVGPLACGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH9</accession>
    <name>Q63TH9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193713.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108587.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1989"/>
    <dbReference type="EnsemblBacteria" id="CAH35988">
        <property type="protein sequence ID" value="CAH35988"/>
        <property type="gene ID" value="BPSL1989"/>
    </dbReference>
    <dbReference type="GeneID" id="56595408"/>
    <dbReference type="KEGG" id="bps:BPSL1989"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4141"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVHAVNI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030827">
        <property type="entry name" value="Myo_inos_IolG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04380">
        <property type="entry name" value="myo_inos_iolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="137"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="36024" checksum="4C7B16327BBF2CA8" modified="2004-10-25" version="1">MTNAAPTIDVAVFGAGRIGRIHAGNLARRPGVRLKYVVDVNRDAAAALAAQYGAQAADVDGALGDASIGASVICSSTDTHAELIVGAARAGKHVFCEKPVDLTLERARACEAAVARAGVVCMIGFQRRFDPTFEALKRRIDAGEIGTPEMLVVTSRDPGAPPVDYIKHSGGIFKDMLIHDFDIFRWILDDDADTLHATGSCLTDPAIAGAGDIDSAAVTIRTKRGRLCQINTSRRAAYGYDQRFEVLGSAGMLQAGNVRPTEVTGYSARAVSTDLPEAFFLERYRAAYAREIAHFFAAVTSGEPVRTTVADGVKALELAEAATLSWREARAVTLGERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TJ5</accession>
    <name>Q63TJ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937757.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108571.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1973"/>
    <dbReference type="EnsemblBacteria" id="CAH35972">
        <property type="protein sequence ID" value="CAH35972"/>
        <property type="gene ID" value="BPSL1973"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1973"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4124"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLYLFKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="733" mass="79022" checksum="9294BC3F98355DC8" modified="2004-10-25" version="1">MPAAPPPSAATPQSAGAAFVASMSDWARTDGAAWLYLAKALAAAFLALGVSMVLDLPAPKTAMTTVFIVMQPQSGAVFAKSFYRLIGTFVGLTATLALVGLFPQQPVLFLLAVALWVAACTAGAARNRNFRSYGFLLAGYTAALIGLPASQAPNGAFMTAMTRVSEISVGILSAGIVSALIFPQYTGEQMRTTVRRRFGAFVDYVAAALAGALDRSKIESVHTRFVADVVGFEAARSMAVFENPDTRMRSGRLSRLNSEFMTASSRFHSLHQLMNRLHATSAQAVDALEPYFREIAPLLSNDGDHVRTSADAARAAEQLLAYRDALPRRIRATRAEHETQPAFPLLDFDTASELLYRFITDLHAYAATYASLAASTHARERWIERYEPRTNATAALIAGIRTASVMLLLSVFWIYSAWPSGVMLVLNAAAVCALASSSPQPTRMAAQMALGTAFAVATGFVLMFGVYPHIDGFVLLCAALAPFLAPGVLMSLRPKYAGCGAGYLIFFCTLAGPENLTHYDPIGFMNDALALVLSMIVSAIAFAVLFPPSAPWLKKRLFADLRHQAVTACHARLPGLRTRFESGARDLMFQAHGLSADQPDAQRDALRWMFAVLETGNAVIDLRHELATLPRDPRYAATMPWRRKIEAARDALAALFDKPAPARFDAALAAAVDAIAATQQALVAFAPPREERHQMQRILSQLHFVRTALLDPESPLAALNGARTPTDRPGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TK1</accession>
    <name>Q63TK1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Trp repressor binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193704.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108565.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1967"/>
    <dbReference type="EnsemblBacteria" id="CAH35966">
        <property type="protein sequence ID" value="CAH35966"/>
        <property type="gene ID" value="BPSL1967"/>
    </dbReference>
    <dbReference type="GeneID" id="56595430"/>
    <dbReference type="KEGG" id="bps:BPSL1967"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4116"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGMLIMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="202" mass="21067" checksum="0685A88D8B50F698" modified="2004-10-25" version="1">MKDILVLYYSRHGATRELALAIAAGIDSVPGMQARIRTVPPVSTVCEATQPDIPDDGPPYAEPRDLDECAGLALGSPTRFGNMAAPLKYFLDGTTPQWLSGALAGKPACVFTSTGSLHGGQESTLLSMMLPLLHHGMLIVGIPYTETALSVTQTGGTPYGASHFARVADPARERISADEKTLAHALGARLARTASQLGAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TT0</accession>
    <name>Q63TT0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108486.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1886"/>
    <dbReference type="EnsemblBacteria" id="CAH35886">
        <property type="protein sequence ID" value="CAH35886"/>
        <property type="gene ID" value="BPSL1886"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1886"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4029"/>
    <dbReference type="eggNOG" id="ENOG5031JPS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NFWRVIK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021350">
        <property type="entry name" value="DUF2968"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11180">
        <property type="entry name" value="DUF2968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266777" evidence="2">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="243" mass="25900" checksum="79151BC570E27F94" modified="2004-10-25" version="1">MSHIRGMGRVFVAIAAAGGLCGAHAQALEGNGGAASPALTASGAAASPGVSAPAVVNLSAPAGAPAAGASTEASGKSTIDELQRQIQARELTEMRTTYNGSYGASLLLNIQEGTYFVALFQQKAFWRVIRTASEARAEAVYRDFAKQSETLAVNELQAAKLESQKALTDRQIAVAQERASRLQADLSIAREQRAAVATRQKDKLDETVALREQKSERQDQLRKLQQQVRSLQRQAEAGLPKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU0</accession>
    <name>Q63TU0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108476.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1877"/>
    <dbReference type="EnsemblBacteria" id="CAH35876">
        <property type="protein sequence ID" value="CAH35876"/>
        <property type="gene ID" value="BPSL1877"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1877"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2116"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVHTSDE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="137"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="508" mass="54384" checksum="96D4B972F6D53766" modified="2004-10-25" version="1">MALSKLDAAHAAAGPDASPDAWPSAALSDRAAVEVDASQLLPTPQLVRWQVDLDRRGLRSTGSPAHERYIDVLRRRLARAGVQQLHTEATTLARWAVRHWRLDVADGAPRERIDVAGYLPYSGDTGRDGIVAPIRYLAAGQTPDADVAGKIAVVEWPALPLTGAFFRERALRVFDPDNAFAPSAPYVRTSFMLGTLTAMLDRLQAAGAAGVVMIADTSSAEATRLYAPYDGRLRRVPGLFVDRATGAKLASLAERRATLRLSLDAGVERVHTRNLIGILPGMSDELTVVNSHTDGTNGIEDNGPNAIVAIAQYLSRLPRAALPRTVMILLSSGHFAGGVGAEDFIARHARDGLVARIACVVTIEHLGAQEWLPSEQGALAPTGRAEPTALFMPAVPALVDAADALVRRANAAPAFVMPPLNPNGDGSANDALWPGEGQYFWGRARVPTINLITGPTYLLNYGVSTAEKIDYARLRREIAATTQMLLDLSRVPFDALRAVPPRMRAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TV6</accession>
    <name>Q63TV6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quaternary ammonium compound-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">qacE</name>
        <name evidence="6" type="ordered locus">BPSL1861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191709.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108460.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1861"/>
    <dbReference type="EnsemblBacteria" id="CAH35860">
        <property type="protein sequence ID" value="CAH35860"/>
        <property type="gene ID" value="BPSL1861"/>
    </dbReference>
    <dbReference type="GeneID" id="56595652"/>
    <dbReference type="KEGG" id="bps:BPSL1861"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3995"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATTAMKY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="112" mass="11887" checksum="CA0830EF8AB232A6" modified="2004-10-25" version="1">MQLPGYAWLAIAIVAEVVGTSALRAAEGFTRLWPTLVVALGYGTAFYCLSLTLKSMPVGIVYAIWSGAGIVLITLVALVLYRQVPDWPAVVGLALIVAGVVVLNLFSKMQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TZ6</accession>
    <name>Q63TZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbriae assembly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
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                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
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                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
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                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">K96243</strain>
        </source>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35820.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UA4</accession>
    <name>Q63UA4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative non-ribosomal antibiotic-related peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1712</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
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                <person name="Vesaratchavest M."/>
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                <person name="Yeats C."/>
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            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
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        </cofactor>
    </comment>
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        <property type="gene ID" value="BPSL1712"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
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    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="6274" mass="673626" checksum="E9201252D33D31B8" modified="2004-10-25" version="1">[encoded data, 6274 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB2</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">BPSL1704</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
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                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
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            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    </dbReference>
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        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="121" mass="13687" checksum="5B2A6E028C0EFA43" modified="2004-10-25" version="1">MEVLMGPERRWRWSVKEKLATARESFEPGKSVSTVARRHRVNPDQLLHWRKLYQDGSLSAVSAGEEVVPTSNLSNALKQIRELQQLLGKKTVDNEIPREAPEAAKSQARIARLLSMPGDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UH5</accession>
    <name>Q63UH5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fimbrial assembly chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the periplasmic pilus chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527078.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108241.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1627"/>
    <dbReference type="EnsemblBacteria" id="CAH35626">
        <property type="protein sequence ID" value="CAH35626"/>
        <property type="gene ID" value="BPSL1627"/>
    </dbReference>
    <dbReference type="GeneID" id="56529346"/>
    <dbReference type="KEGG" id="bps:BPSL1627"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3693"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MKYPFSS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036316">
        <property type="entry name" value="Pili_assmbl_chap_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001829">
        <property type="entry name" value="Pili_assmbl_chaperone_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016148">
        <property type="entry name" value="Pili_assmbl_chaperone_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02753">
        <property type="entry name" value="PapD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00969">
        <property type="entry name" value="CHAPERONPILI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49584">
        <property type="entry name" value="SSF49584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267578" evidence="5">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="6">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_C" evidence="7">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="27240" checksum="442496068063FD8A" modified="2004-10-25" version="1">MRLPTVCHAAFTAVLALCGTAAHAGIQVGGTRVVFDAKVDVRDASVAVRNKGETPYVIQIFVDDGNGNTRRMPFAVTPPLFRLDGGKEQRVSVRYVKRGAGLPQDVESVYWLNVKEIPPTEKRNADINTLKIAVLTRIKLFYRPAGLAGSAADAPSRLKWSVVPNPIGQGVALKVSNPSAYHVTFSTIEIQAAQNASVNADMVNPKGELIVPIPPKAVSQVGPVKFSYTTINDYGAVTPATEVTAQPAGTPEAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UN7</accession>
    <name>Q63UN7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527136.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108179.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1559"/>
    <dbReference type="EnsemblBacteria" id="CAH35560">
        <property type="protein sequence ID" value="CAH35560"/>
        <property type="gene ID" value="BPSL1559"/>
    </dbReference>
    <dbReference type="GeneID" id="56529284"/>
    <dbReference type="KEGG" id="bps:BPSL1559"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3606"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LCITRAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="27057" checksum="812AC571F7F926B0" modified="2004-10-25" version="1">MLISLVLGSIVGAVLGLTGAGGGILAVPALVVGMGWPMQQATPVALVAVAGSAALGALEGFRRGLVRYRAAFLMAAAGVPLTTLGVRVAHRLPQRVLLALFALVMLVVAVRLLRQALRHAAGEPACSPLCVGRVNPDTGRLVWSWPAGIALASTGALTGLMTGLLGVGGGFVIVPMLRKFTNVTMHGIVATSLMVIALVGTGGVIATIASGTPAPLDVTLWFTATTALGMAAGRWVSRYLSARHVQLGFAAALVCVAAGLLAKAALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UQ1</accession>
    <name>Q63UQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538235.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108165.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1545"/>
    <dbReference type="EnsemblBacteria" id="CAH35546">
        <property type="protein sequence ID" value="CAH35546"/>
        <property type="gene ID" value="BPSL1545"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1545"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3590"/>
    <dbReference type="eggNOG" id="COG0390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PWYEPQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00245">
        <property type="entry name" value="TIGR00245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="272" mass="28966" checksum="BDB0341518651F53" modified="2004-10-25" version="1">MNTPLQDLSLVDVGIAAALVAINGAISVALSLGLGRKLAWAAARTVVQLLAIGYVLGWVFGHPRWYVVLPLVALMTLIAGFAGAARGKRTYAGQRADSVLSIWASSWFVAAIGLFVVIRIHPWYAPQYAIPILGMILGNTLTGVSLGVERMMEELTARRDRVETALALGATRWEAAQDAARQAVRAGMLPTLNQMAVVGVVSLPGMMTGQVLAGQSPLQAVRYQIVIMFLIAAASALGTVGAVLSTYRRLFSAEHRFLASRLVEREKTANGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US0</accession>
    <name>KUP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable potassium transport system protein kup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kup</name>
        <name type="synonym">trkD</name>
        <name type="ordered locus">BPSL1526</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550348.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108146.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63US0"/>
    <dbReference type="STRING" id="272560.BPSL1526"/>
    <dbReference type="EnsemblBacteria" id="CAH35527">
        <property type="protein sequence ID" value="CAH35527"/>
        <property type="gene ID" value="BPSL1526"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1526"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3565"/>
    <dbReference type="eggNOG" id="COG3158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AADQFEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000209005" description="Probable potassium transport system protein kup">
        <location>
            <begin position="1"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <sequence length="630" mass="68661" checksum="FC4A45EE22416931" modified="2004-10-25" version="1">MTDTNHSSMRQHSLQSLAIAAIGVVFGDIGTSPLYSLKEAFSPAHGIPLTPSAILGVISLLFWAIILVVGIKYVLFVMRADNNGEGGVLALMALSLRPLNPKSRITGLMMALGIFGACMFYGDAVITPAISVMSAVEGLEVATPQLSHLVLPITIVILIALFWIQRHGTATVGKLFGPIMVLWFVTIAVLGIYHIARAPMIVSAINPYYAFSFMSEHVLLAYVVLGSVVLVLTGAEALYADMGHFGAKPIRLAAYVLVMPSLVLNYFGQGALLLLDPKAIENPFFLLAPQWAALPLVVLSTVATVIASQAVISGAYSLTSQAIQLGYVPRMKILHTSELAIGQIYVPVVNWLLLFVILCIVIGFKSSDNLAAAYGIAVTATMVITTILAAVVMVKVWNWNKLLVAMIIGVFLVIDLGFFGANLLKVEQGGWLPLGIGALLFFLLMTWYKGRHIVKERTAADGIPLAPFLQGLLAHPPHRVSGTAIYLTGNDTLVPVSLLHNLKHNKVLHERTIFMTFVTRDIPYVKDHERVTVHDAGEGLYIVKAEYGFNETPDVKAVLEEVARQRGMTFELMDTSFFLARETVVPTHLPGMSIWRERVFAWMHQNAAKPTDFFAIPANRVVELGTKIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V02</accession>
    <name>Q63V02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521284.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108064.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1442"/>
    <dbReference type="EnsemblBacteria" id="CAH35444">
        <property type="protein sequence ID" value="CAH35444"/>
        <property type="gene ID" value="BPSL1442"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1442"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3464"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPVSYFT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="395" mass="43317" checksum="2AD811F10F6557AE" modified="2004-10-25" version="1">MLTIDDLWRIADAPLHSWLGTLVVSALVLLAVAGIHWIGARIVKPIARPYPFMSVIVSYIDRPSFALLSLLALEFLWLQVDESLSHVGGLRTLAAVGTIAALTWLLMRLAAAVGDAIIRAHPIDTADNLEARRIHTQTRVLARTVMVLIVIIGTGAALMTFPNVRQIGASLLASAGVAGLVAGIAARPVLGNLIAGLQIALSQPIRLDDVVIIQGEWGRIEEISGTYVSVRLWDQRRLIVPLQWFIENPFQNWTRSSAELIGTVFLYVDYRLPLEPLRAELARIVADAPQWDGRVQVLQVTDATERSMQLRALVSARDSSLAWDLRCRVREGLIAFINAHYPHCLPRERTEWTTPDALAREPLRGERAPEPAASNAAFTAADPTTSEAGVPRAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V75</accession>
    <name>Q63V75_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">ppk</name>
        <name evidence="12" type="ordered locus">BPSL1366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521820.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1366"/>
    <dbReference type="EnsemblBacteria" id="CAH35364">
        <property type="protein sequence ID" value="CAH35364"/>
        <property type="gene ID" value="BPSL1366"/>
    </dbReference>
    <dbReference type="GeneID" id="56526472"/>
    <dbReference type="KEGG" id="bps:BPSL1366"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.113"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="122"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="331"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="510"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH35364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="686" mass="77468" checksum="9925B8C052EE734B" modified="2004-10-25" version="1">MSLRYPLLNRELGILGFNERVLAQAADPHVPLLERLRFICITSSNLDEFFEVRMAGLQEQMRDNPGALAPDGMSLQHVYDLVVERAQRLVHRQYTMLHETILPALEQEGIYFHGTETWSDAQIEWARRYFFDELLPVLTPIGLDPAHPFPRVLNKSLNFVIELEGRDAFGRQAVMGIVQAPRALPRLVRMPHALSGFQHGFVLLSSLMQRFVGELFPKLVVKSCNQFRITRNSELFVDEDEITNLRVALQGELPARHLGNAVRLEVSADTPAHLVRRLLDESGLTEKDCYRVDGPVNLVRLMQLPDLVDLPELKFTPFLPAISPAIANAPSMFDAIDHGDILLHHPYESFQPVLELLQQAAQDPSVVAIKQTIYRTGTDSPLMDALMEAARNGKEVTVVVELLARFDEETNINWAAQLESVGAHVVYGVVGHKCHAKMMLIVRRVTQGGKSVLRRYVHLGTGNYHPRTARLYTDFGLMTSEPTICEDVHHVFQQLTGIGGELKLHEMWQSPFTLHPRLIEHIRAEAGNARAGKRARIVAKMNALLEPTVIAELYEASQAGVKIDLIVRGVCALQPGVPGLSENITVRSIVGRFLEHHRIYYFHANGEELVYLSSADWMDRNLFRRVEVAFPVRERKLKRRVIAEGLSVFLGDNQSAWLMQSDGHYRRRRAGKAPRNAQLGLLAKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD7</accession>
    <name>Q63VD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526536.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107929.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35302">
        <property type="protein sequence ID" value="CAH35302"/>
        <property type="gene ID" value="BPSL1305"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1305"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.191"/>
    <dbReference type="OMA" id="PPRRHIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="384" mass="42015" checksum="CD10B0A271FF1950" modified="2004-10-25" version="1">MTSPAQPTWRDTLSAFAYRHLRLPPPKLETGRFGWATRWFLDWLVPTGASAWAAYHLAAAFVAHYRSVLPANVGPDVPLGVMSELMSLANSKPFAYTGISLVAVLVALMFHRYLTWPAPGRWLNRRKRPVIHALPFMLGFLAGKLLAFAVPALAVAVAAYASEGAIGAIAPLAAPIALLSAAYYFLLYDEVRPPAIVSLSFHRSRQRSAGACAIHQAREPDGAAAVGIGAWRDAHDELRDDVLAIADAAGGMCGQNVFVSHDIDDIAIAIALSIDEAHRSDRQKRSLDAQIDRVLRKWRDRGYASGSLHDAKATRASPGAPEARWPDVAFWLPESERIVRHGSVLLKARDGRDVRIVEDPIGSVQADASAVRPRPRRMRTFEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF3</accession>
    <name>Q63VF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936984.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107913.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1291"/>
    <dbReference type="EnsemblBacteria" id="CAH35286">
        <property type="protein sequence ID" value="CAH35286"/>
        <property type="gene ID" value="BPSL1291"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1291"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.215"/>
    <dbReference type="eggNOG" id="ENOG5033FFY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SKDAMGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014299">
        <property type="entry name" value="Penta_MxKDx"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02953">
        <property type="entry name" value="penta_MxKDx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266798" evidence="2">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10151" checksum="5DB1D6BF439E938E" modified="2004-10-25" version="1">MKRNLIAFACVAGFALAAPFAHAQNDAMSKDGMGMSKDAMSKGAMSGDAMSKDAMSKDRMGKRHDHMAKGGMKAGPMSKDAMKEPMSSDKMSPMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VH1</accession>
    <name>Q63VH1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547716.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107895.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1274"/>
    <dbReference type="EnsemblBacteria" id="CAH35268">
        <property type="protein sequence ID" value="CAH35268"/>
        <property type="gene ID" value="BPSL1274"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1274"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.236"/>
    <dbReference type="eggNOG" id="COG5553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HAHHTWC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0883">Thioether bond</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="4">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="23170" checksum="D0438A52C07BD873" modified="2004-10-25" version="1">MNHAASSLPHAPDPHPKPRERAPSAPCRDRATPASTPIARFCTRLDAAFDSLRDETAPSRHPAFARALRAALAEAAAAPGLLTPAQRESGAAGYRRHLLAADPAGRYAVVSLVWEPGQWSPVHGHHAWCGYAVLEGKLTEIVYRWSDAACCAIDARRRARPMGAVSYVCAGRDAIHRLGHAGAKTDAPAISLHVYGVAGEQVATHVNDVVAVDARAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VP9</accession>
    <name>Q63VP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204966.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107817.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1195"/>
    <dbReference type="EnsemblBacteria" id="CAH35190">
        <property type="protein sequence ID" value="CAH35190"/>
        <property type="gene ID" value="BPSL1195"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1195"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.333"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVQDSMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="124"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="186" mass="20911" checksum="F733FD5CE24AB80C" modified="2004-10-25" version="1">MASDKELADFLAGVERRAFKQAAYAVRDDDASLDIVQDVMIRLAEKYGDRPAAELPLLFQRILQNAIHDYFRRQKVRNTWVSLFSSLNNTDDDEFDPLETLESADGDGVESGETRLEREQVLALIDDEIQKLPARQREAFLMRYWEDMDVAETAAAMGCSEGSVKTHCSRATHALALALKAKGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ1</accession>
    <name>Q63VQ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526454.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107815.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1193"/>
    <dbReference type="EnsemblBacteria" id="CAH35188">
        <property type="protein sequence ID" value="CAH35188"/>
        <property type="gene ID" value="BPSL1193"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1193"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.335"/>
    <dbReference type="eggNOG" id="ENOG5032YRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARENYQV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021455">
        <property type="entry name" value="DUF3106"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11304">
        <property type="entry name" value="DUF3106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="27013" checksum="B3E61FDAF6081560" modified="2004-10-25" version="1">MSQKRGLAVFFGCVIALVVAYAATYPRFHPQPAAVAAASAPVIASAAIALSSGEFPPLPPSSPLSWGRLTPQQHVALAPFASQWDSFSDERKRKWLKIAARFPRMSPEAQKRLQERMTEWVRMTPEQRRVARENYLVSKDLSAQAREKAWKAYQQLSPEQKEKLAAAERRRRPTVVSAPPTGKTDRDINRLVNAHDRHPASAPTASIAPSAASAPAAAPVPASPATTGAVTPPTAPTPVSPSEAPSLFNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VT2</accession>
    <name>Q63VT2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="7">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nadD</name>
        <name evidence="10" type="ordered locus">BPSL1162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185801.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107784.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1162"/>
    <dbReference type="EnsemblBacteria" id="CAH35157">
        <property type="protein sequence ID" value="CAH35157"/>
        <property type="gene ID" value="BPSL1162"/>
    </dbReference>
    <dbReference type="GeneID" id="56595092"/>
    <dbReference type="KEGG" id="bps:BPSL1162"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1280"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRDWRKL"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="9">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="250" mass="26853" checksum="E9270A63044787AE" modified="2004-10-25" version="1">MSRAATGRAAAPQGPTPNAEPAGLPALPRRIGILGGTFDPIHDGHLALARRFAHVLRLTELVLMPAGQPYQKQDVSAAEHRLAMTRAAAASLVLPGVAVSVATDEIEHAGPTYTVETLARWRERIGDRASLALLIGADQLVRLDTWRDWRRLFDFAHVCAATRPGFDFTAASPAVAAEIASRQASADVLQATPAGRLLIDTTLSLDVAATDIRAHLRACIARRAQVPDASAEHVSPAVWAYILQHRLYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX6</accession>
    <name>Q63VX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LPS biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526415.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107740.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1119"/>
    <dbReference type="EnsemblBacteria" id="CAH35112">
        <property type="protein sequence ID" value="CAH35112"/>
        <property type="gene ID" value="BPSL1119"/>
    </dbReference>
    <dbReference type="GeneID" id="56526722"/>
    <dbReference type="KEGG" id="bps:BPSL1119"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.429"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EPHRINV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="360" mass="39077" checksum="D504CCBBFA571A05" modified="2004-10-25" version="1">MKIGLSCNALKYGGGLERYAIDLARGLADAGIRPSVFARSFDSSVPEYRRVESHRINVSFLPGKCRDAWFSWRLRAARRASPVDVLIGCNRVDSSEIAICGGTHLGFLDAIGRVPTFADRRQIALERRQYAHARFVIAHSMLMRDELLHFYGLGDDKVRVLFPPVDAARFTPVHAVRRAELRTRFGFADDEIVLLFPSSSHERKGLPLIEAVLRDAGPGIVVAVAGRPPERTSERLRYIGYVKDIEDGYRAADFTILASKYEPFGLVGVESVMCGTPVILPSNIGCCDAIAPSAKLVFAPGDTAGLRAALDEAVRRTKAGAARVGSGAAAHAAIRYDPSIARHVAQLLDLAVEAAGDGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W08</accession>
    <name>Q63W08_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107708.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1086"/>
    <dbReference type="EnsemblBacteria" id="CAH35080">
        <property type="protein sequence ID" value="CAH35080"/>
        <property type="gene ID" value="BPSL1086"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1086"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1179"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGHYRKH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="489" mass="53815" checksum="8850BE237702E51E" modified="2004-10-25" version="1">MEASPMSTVPLAQIPAPHDTATLTLVDQLVQWARRRIDERVFRPGMRMPSIRKLALDKSVSRFTVVEAYERLVAQGYLDSRRGSGFYVRERAPGQQPVGASGGARAQPVHNTIDVVWLLRNMLHTVSPEKGPGLGYLPSRWLDGELITSALRALGRQSGAQMLGFGSAQGFLPLRQQLQTRLAEFEIGATPDQLVLVSGITQAIDLIARHCVRPGDAVIVGDPAWFQMFGRFASQGAQLVGMPYTPDGPDLDALENLVQMWRPKMLVINSVLHNPTGTSLSAAQAFRILKLAEAYDFLVVEDDVYGDLCPPSYPATRLASLDQLRRVIFLGSFSKTLAANLRVGYIACAPELAKALTDQKMLVGMTTPELNERVLYKVLTEGHYRRHVERLRARLDGVRDKTARMLERTGMRLFTMPAAGMFLWADTGVDSDALAAAAHEEGFLLTPGSLFSPQQSPSTWTRFNVANCGDPALPAFLGRYLDSVNRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W67</accession>
    <name>Q63W67_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">BPSL1021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522531.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107649.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63W67"/>
    <dbReference type="STRING" id="272560.BPSL1021"/>
    <dbReference type="EnsemblBacteria" id="CAH35017">
        <property type="protein sequence ID" value="CAH35017"/>
        <property type="gene ID" value="BPSL1021"/>
    </dbReference>
    <dbReference type="GeneID" id="56526814"/>
    <dbReference type="KEGG" id="bps:BPSL1021"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.547"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="19161" checksum="C5172369FBE52154" modified="2004-10-25" version="1">MSFSNVPAGKDLPQDFNVIIEIPAQSEPVKYEADKALGLLVVDRFIGTGMRYPVNYGFIPQTLSGDGDPVDVLVITPFPLLAGSVVRARALGMLKMTDESGVDAKLVAVPHDKVCPMTANLKSIDDVPAYLKDQIKHFFEQYKALEKGKWVKVEGWDGIDAAHKEITDGVANFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W72</accession>
    <name>Q63W72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative bifunctional protein (Uroporphyrin-III C-methyltransferase and uroporphyrinogen-III synthase transmembrane protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107644.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1016"/>
    <dbReference type="EnsemblBacteria" id="CAH35012">
        <property type="protein sequence ID" value="CAH35012"/>
        <property type="gene ID" value="BPSL1016"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1016"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1102"/>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWFLREN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007470">
        <property type="entry name" value="HemX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38043">
        <property type="entry name" value="PTHR38043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04375">
        <property type="entry name" value="HemX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="4">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="660" mass="70183" checksum="BF2D1FA40D0D9044" modified="2004-10-25" version="1">MMAGAPRTFTAVLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNAVDHALARLGAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDSESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSIGAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVETARALGFDRITLTGAGDERIVRAFRTLADQADQPATAAPMPSRMTDTNDTKDVSSKPAAAPVAPPNQPFTPFETKERRGAASAALWFVVVVIAAAAGVGGYALNRKVDRLDQHATERQKALDAQTAELRTKTEQALASVRQADSQLSQLEGKLADAQTAQTALQQQYQDLSRNRDAWMIEEVGQMLSSASQQLLLTGNTQLALIALQNADARLASSQSAQAVVVRKAIAQDIERLKAAPSADLTGLAIKLDDAIAKVDTLPLAGEVLAPHAQAKPDAAASARQAAAAAGEPRWKAWWRGFSAGIGEQLKSLVEVRRIDHADAMLASPEQGYFVRENVKLRLLSARLSLLARDDGAMKSDLHAAQAAVARYFDGASKDTRVVQDLLKQVDAASLTVAVPNLNTSLNAVQQFKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WA8</accession>
    <name>Q63WA8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">BPSL0980</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell inner membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191554.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107608.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0980"/>
    <dbReference type="EnsemblBacteria" id="CAH34976">
        <property type="protein sequence ID" value="CAH34976"/>
        <property type="gene ID" value="BPSL0980"/>
    </dbReference>
    <dbReference type="GeneID" id="56596210"/>
    <dbReference type="KEGG" id="bps:BPSL0980"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.594"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHTGDTY"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAH34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="252" mass="26484" checksum="0ED8988FFC8E3315" modified="2004-10-25" version="1">MNPLAELRYFVVALGYFTRVPVPRAISGQAVDLAHAARYFPLVGVCVGALAAAVHLAASRVWPPGVAALASIAATLVATGALHEDGLADSCDAFGGGYTREDVLRIMRDSRIGTFGAAALVVALALKWQALAAMPPARAAWTMIAAHAASRTLAASLLLTLDYARAEGKAQPVAHRMRAGAFAFAAALGLPWLFWPDWRAGALALAAMLVLRAGIARYLDARIGGYTGDCLGFAQQVFELSIYLAMLGWMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WU5</accession>
    <name>Q63WU5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pgk</name>
        <name evidence="11" type="ordered locus">BPSL0796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550814.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107421.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0796"/>
    <dbReference type="EnsemblBacteria" id="CAH34788">
        <property type="protein sequence ID" value="CAH34788"/>
        <property type="gene ID" value="BPSL0796"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0796"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.809"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="26"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="397" mass="41233" checksum="F69817B146E3B980" modified="2004-10-25" version="1">MSQVKRLTDLIAEGKLSGKRVFIRADLNVPQDDHGNITEDTRVRASVPAIQAALDAGAAVMVTSHLGRPTEGEFKPEDSLAPVAKRLAELLGRDVPLVANWVENGVEVAPGQVVLLENCRVNKGEKKNSDELAQKMAKLCDVYVNDAFGTAHRAEATTHGIAKYAPVACAGPLLAAELDALGKALGNPKRPLVAIVAGSKVSTKLTILKSLAEKVDQLIVGGGIANTFMLAAGLAIGKSLAEADLVGEAKAIIDEARKRGASVPIPTDVVVAKEFSPTAAATVKKVADIEADDMILDIGQDTAKALAGQLEKAGTIVWNGPVGVFEFDQFGNGTKTLADAIASSAAFSIAGGGDTLAAIAKYGIHDKVSYISTGGGAFLEFLEGKKLPAVEVLETRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WW2</accession>
    <name>SUCC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="1">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="1">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sucC</name>
        <name type="ordered locus">BPSL0779</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189251.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107404.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WW2"/>
    <dbReference type="SMR" id="Q63WW2"/>
    <dbReference type="STRING" id="272560.BPSL0779"/>
    <dbReference type="EnsemblBacteria" id="CAH34771">
        <property type="protein sequence ID" value="CAH34771"/>
        <property type="gene ID" value="BPSL0779"/>
    </dbReference>
    <dbReference type="GeneID" id="56596590"/>
    <dbReference type="KEGG" id="bps:BPSL0779"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.830"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_1000082045" description="Succinate--CoA ligase [ADP-forming] subunit beta">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <sequence length="388" mass="41286" checksum="754545D0C74249A7" modified="2004-10-25" version="1">MKIHEYQGKEILRKFGVAVPRGKPAFSVDEAVKVAQELGGPVWVVKAQIHAGGRGKGGGVKVAKSLEQVREYSNQILGMQLKTHQTGPEGQKVNRLLIEEGADIKKELYVGIVIDRVSQKVVVMASSEGGMDIEEVAEKTPEAIHKVAVEPSVGLQDAEADDLAKKIGVPDASIPQAREILKGLYKSFWETDASLAEINPLVLTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDPAEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTEAFKLMLKNPGLKAILVNIFGGIMRCDVIAEGVIAGSKAVNLNVPLVVRMKGTNEDLGKKMLAESGLPIISADSMEEAAQKVVAAAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WW4</accession>
    <name>Q63WW4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="6" type="ordered locus">BPSL0777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107402.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0777"/>
    <dbReference type="EnsemblBacteria" id="CAH34769">
        <property type="protein sequence ID" value="CAH34769"/>
        <property type="gene ID" value="BPSL0777"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0777"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.834"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RCKMQEK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="205" mass="22540" checksum="2A5848896E953965" modified="2004-10-25" version="1">MSSAAKREETAGDVYTRTSQAGPRSRRRASPFHSDSSPSASSETDGAARSSASQRPARTLKGRAVAYLSRREYSRAELARKLTPHADESDDVESLLDALERENWLSDSRFAESLVHRRASRVGSARIISELKRHAVGDALVESVGARLRESEFERAQSVWRKKFGAVPQTQAERAKQARFLAMRGFSSATIAKLLKGDADEFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WZ3</accession>
    <name>Q63WZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204875.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107373.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0747"/>
    <dbReference type="EnsemblBacteria" id="CAH34739">
        <property type="protein sequence ID" value="CAH34739"/>
        <property type="gene ID" value="BPSL0747"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0747"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.858"/>
    <dbReference type="OMA" id="FMETINW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="493" mass="55341" checksum="4067649E3EC94212" modified="2004-10-25" version="1">MVKDVKNYTDEEFRRARENLADILSLEERTASEILHDGHLNDVSFLVGLFRKASNTLAHKWNAPLLAKLPVDAWDVGPAGERRITPRDFASMRYLSPLLTGKDKETAELWAGEREKLLKELHEPGGPYAAMTEWKAPKQFKSKGAQSLPFSGDIAFMETINWLDTLLGFQITLFAGRRHKALGLPLSVALPANEDKRCSRDALQFMKQNVDAWCKDASLAGEASDSLRARVAVNLSVNRALWETCAKDARGEESATVAAQFLSRLNGCGIWMVPDEVPTRGAEWTGLAELLSRWFGAKGWLREKDDFFARVMTPHDIDRAVQLTESVQKRYKANRGGNCGPEQAELAHGSPENLFIFAMATVSVFYVKGYWGGKSQLRPVQTLKEFPAKHNKNSSRYPAFSTLDSGDGLMLPIHAEELIEQVYGQMFFSNQGWDLRAESVRQHAETQTIKRAYHEQLFEFAVKGRTSKELLNLFTQVAAYIEQQKENGAIVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X11</accession>
    <name>Q63X11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107355.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0729"/>
    <dbReference type="EnsemblBacteria" id="CAH34721">
        <property type="protein sequence ID" value="CAH34721"/>
        <property type="gene ID" value="BPSL0729"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0729"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.797"/>
    <dbReference type="eggNOG" id="COG3519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPDPHVE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028304">
        <property type="entry name" value="UCP028304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="645" mass="69802" checksum="389229AFBB5F696B" modified="2004-10-25" version="1">MPPQPPIFARAPPLAARGRRADERAPRDRAVRPHPDRPLPMNDLLPHYEREIALLRRSMREFARRHPKIATRLGIADGQADDMHVERLIQSFALVGAQIGAALDDEYPEFTEALVETVCPDYLRPFPACSIAQFDAPPLFGQPAEGVTIARGTTLESRIGANRFRTAYDVTLAPVSIVDARFRPASAAPSAARMPPQSTGIVSITFDALTAQPVLAALRARGLRVHLHGDAPLVAALADTLAMRAPAAFIELDGDGRWKPLSKVPLARVGFADAHALLDPAPGAAPFRLLMEYFAFPAKFDFVDIDVARIARAAGPCRRLSLHLPVVDVAMASQHARALDTLGASNLRLFCTPIVNLFSQDAMPISLRDAEAVYPVTPQALKSNGIEVRSIDAVRIAREGEPGASLDVTPYRSLLHGRHGGRDAPVYWVAQRERFAPGSPPAALRLVDADGANARLGADQLNVELTCTNGDYPQTLPIGEPDGDLLNEKDNLPGRIALLRRPTPARRFAREHGALWRMIAAMTPHALLLQPSGLGALKALLVQHAARASSAAPQIDAIANLDHKVAVRWMAVKPMPTFVRGIEIALTLNEAAFVTSGLKTFIDVMDGFFALHAPPNGFVQLVAYSRDTGRELHRCAPRGAIAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X29</accession>
    <name>Q63X29_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204859.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107337.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0709"/>
    <dbReference type="EnsemblBacteria" id="CAH34702">
        <property type="protein sequence ID" value="CAH34702"/>
        <property type="gene ID" value="BPSL0709"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0709"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.906"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVHRRND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="49"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="29920" checksum="5EE4E7F4CCB61FC6" modified="2004-10-25" version="1">MSGSPRPGATRPTSTPATSEGETYLGYATRIVADIRQMADAVRASRSVPRGLLRVNAMLGFGRTTITPLVSEFATPHPRVEVRLDVTDRPVDRVDGGSDLAIRFGEPPDTRLNARRIMSNRRLLRASPVYLQRRGAPASLARCIVHRRNDDAHGVWRFVRDGEAEGVKVRAAPSSNDGDIVPGWALDGHGILIRSEWDLAKYLESGRLRRVLPEYALPSADLSACYPVRRNPSARARAPIDFLVARLGASAPAPARTPEGGRRAGSRDVPPRVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X65</accession>
    <name>YBEY_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">BPSL0672</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH34665" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34665.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63X65"/>
    <dbReference type="SMR" id="Q63X65"/>
    <dbReference type="STRING" id="272560.BPSL0672"/>
    <dbReference type="PRIDE" id="Q63X65"/>
    <dbReference type="EnsemblBacteria" id="CAH34665">
        <property type="protein sequence ID" value="CAH34665"/>
        <property type="gene ID" value="BPSL0672"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0672"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKEWKRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000102429" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="184" mass="20311" checksum="4D155EAC0C1C5BF1" modified="2005-02-15" version="2">MTVEVGADENPDFAHDETDGAGDESDDEDAQGRDPELDLAVQYGDEIGDAQRKSLPKRKVIAEWLEPAIFSDAQFTVRFVGADEGRALNHSYRHKDYATNVLTFAYGEEPDGVTVADLVLCCPVVEKEAREQGKTLVAHYAHLLVHGALHAQGYDHERGEEDAAEMEALEIDILAKLGFPNPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X91</accession>
    <name>Q63X91_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cardiolipin synthase B</fullName>
            <shortName evidence="1">CL synthase</shortName>
            <ecNumber evidence="1">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clsB</name>
        <name evidence="3" type="ordered locus">BPSL0646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522800.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107275.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0646"/>
    <dbReference type="EnsemblBacteria" id="CAH34639">
        <property type="protein sequence ID" value="CAH34639"/>
        <property type="gene ID" value="BPSL0646"/>
    </dbReference>
    <dbReference type="GeneID" id="56527143"/>
    <dbReference type="KEGG" id="bps:BPSL0646"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.976"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYCQRPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01917">
        <property type="entry name" value="Cardiolipin_synth_ClsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030872">
        <property type="entry name" value="Cardiolipin_synth_ClsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="424" mass="47186" checksum="ABA144BB02958D6A" modified="2004-10-25" version="1">MSGETRHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVALETYIFCDDAVGRAVSDALVRAAARGVHVRVITDGIGTERLPLFGTWPDAGVEHRIYNPYLFGRFGFSRTHRKLAVIDDACAFCGGINIVDDFEQNGERLPHPRWDFAVELAGPAVADVRAAFEVQWHRIAAGHKRYAQYLPHDVDGPAFAARFRRWMRSHRWVKAGALRVVTEPSVAFVARDNIVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNEFASLDMAVPFLYHALLRSGVRVAEYDKTMLHGKVAVIDDHWATVGSSNLDALSLMLNNEANVVLVRHREETAALRDAIAAAFADGREIDPALYAARPAAERFLNWFAYNAYRSAMKLLTVGGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XC4</accession>
    <name>Q63XC4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196302.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107241.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0612"/>
    <dbReference type="EnsemblBacteria" id="CAH34605">
        <property type="protein sequence ID" value="CAH34605"/>
        <property type="gene ID" value="BPSL0612"/>
    </dbReference>
    <dbReference type="GeneID" id="56593659"/>
    <dbReference type="KEGG" id="bps:BPSL0612"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1015"/>
    <dbReference type="eggNOG" id="ENOG502Z9WS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQETNCY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014989">
        <property type="entry name" value="DUF1839"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08893">
        <property type="entry name" value="DUF1839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="40907" checksum="F1F964E0164891BA" modified="2004-10-25" version="1">MSSILLDAPGNGASLEDIFTDIRHRVRHYRPHALHGPQMVWKQTNCYVDLWIEVLGWWGLNPYAALPFTITLDFEGDQFSFFKFPFEDLETLYGIVVQEHAIFEPVDVHVEHQVARGNLMLVEVDAWYLPDTRGNSYQSEHTKTTIGIDAIDRERRRVGYFHNSGYYLAEGVDYDGLFGKHGPAHLVPYVERAKRQFKPLEERELCDASLALLARHLKRRPASNPIAAFREQLARDAKTIASQPISYFHAYSFNTLRQLGANFELFGRYLRWLEASGCGGPIDTLVAACDTIASEAMVLEFRLARASARGKEERGESSLDILERAHASLIDGVARIAPPGRVEPNPPFGTLYVPPRPVTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP2</accession>
    <name>Q63XP2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoenolpyruvate--protein phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL0498</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107123.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0498"/>
    <dbReference type="EnsemblBacteria" id="CAH34487">
        <property type="protein sequence ID" value="CAH34487"/>
        <property type="gene ID" value="BPSL0498"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0498"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1157"/>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGHGVAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="12">
        <location>
            <begin position="36"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HPr" evidence="13">
        <location>
            <begin position="196"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="872" mass="90964" checksum="135869E09DE6F3EF" modified="2004-10-25" version="1">MRRAEESQLKQQASHDQIVLVAPLTGPVVPLADVPDPVFSGGMFGDGIGIDPLEGRLLAPCAGVVSHVARTGHAVTIAADGGAEILLHIGIDTVELNGLGFTAKIAEGARVAAGDLLIEFDQDAIARAAHSLVSVIAIANSDAFEVVERAGAGVVKAGETPLLALRARGAGASAGTSASASAGAAADASCAQPAAEARKSITLTQPGGLHARPAARAREAARGLDAHVDVHFEGRKAALQSVVGLLGLGAGEHATIELVATGRDAAKALERVAHELLREAHGEAEEKPARIVSPAPAAAGIARAPLEPNTLAGVCAAPGIAVGTLVRWDDAQIVPPELASGTPAAESRLLDRALAEVDAQLETTVREASRRGAIGEAGIFAVHRVLLEDPALVDAARDLISLGKSAGYAWRETIRAQTAVLADVDDTLLAERAADLRDIDKRVLRALGYASASARELPAEAVLAAEEFTPSDLASLDRERVAALVMARGGATSHAAIIARQLGIPALVAVGDALYAIAQRTQVVVDASAGRLEYAPSALDVERARHERQRLAGVREANRRMSGEAALTRDGHRIEVAANIATLDDARVALDNGADAVGLLRTELMFIHRQAAPTASEHQQSYQSIVDALQGRTAIIRTLDVGADKEVDYLTLPPEPNPALGLRGIRLAQVRPDLLDDQLRGLLAVKPYGSVRILLPMVTDVGELVRIRKRIDDFARAMGRAQAVEVGVMIEVPSAALLADQLAQHADFLSIGTNDLTQYTLAMDRCQADLAAQADGLHPAVLRLVDATVRGAEKHGKWVGVCGALGGDPVAVPVLAGLGVTELSVDPVSVPGIKAQVRRLDYQLCRQRAQDLLALESAQAVRAASREIWPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XQ4</accession>
    <name>Q63XQ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009918533.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107111.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0486"/>
    <dbReference type="EnsemblBacteria" id="CAH34475">
        <property type="protein sequence ID" value="CAH34475"/>
        <property type="gene ID" value="BPSL0486"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0486"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1169"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HARAQWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="30"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="50"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="398" mass="42500" checksum="C05A617B4D11487C" modified="2004-10-25" version="1">MNTDTIGSAPHAAADAGNAEWLDGLDTPCYVFDPQCVLAGYAALRAALGTRLVVSLKANSHADLFLRCAHAFEDGIELASQGELDTVVGRGKHVKYLNNPAMGDALMRAGIASRCHFILDGPDMVRRFIALASGKETEDVMLRINAGALLGAHAPKSLRDHFGMTPAEALGMANLLTQAGRRVAGLHAFVGSGNFRAGPTKGGDADSADLAWALAQLAEQIEALVRTPVTHLNLGGGFSEKGHDDATFERYRARIAPLAKRYTLVHEAGRAIFANAGVFVTRVRAVKVWDDRVIAVCDGGMSHNFLLAKTEAVLKTWAAPTLVPAGAADAHRAPNARPITFVGNTCNRADVIGRLERHPRLPQPGDFVVFSQCGAYHHSYTVSGFLSHKPAQVYIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XT9</accession>
    <name>Q63XT9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Malonyl-[acyl-carrier protein] O-methyltransferase</fullName>
            <shortName evidence="5">Malonyl-ACP O-methyltransferase</shortName>
            <ecNumber evidence="3 5">2.1.1.197</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biotin synthesis protein BioC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioC</name>
        <name evidence="7" type="ordered locus">BPSL0451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17105"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9954"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78845"/>
            <dbReference type="EC" id="2.1.1.197"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.197" evidence="3 5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204803.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107076.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0451"/>
    <dbReference type="EnsemblBacteria" id="CAH34439">
        <property type="protein sequence ID" value="CAH34439"/>
        <property type="gene ID" value="BPSL0451"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0451"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1206"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PSMWELM"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010340">
        <property type="term" value="F:carboxyl-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102130">
        <property type="term" value="F:malonyl-CoA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00835">
        <property type="entry name" value="BioC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011814">
        <property type="entry name" value="BioC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="6">
        <location>
            <begin position="58"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="321" mass="35407" checksum="F31B60D310A5FF61" modified="2004-10-25" version="1">MSPASAKTSRPAYDPRRLRRIFDRRAAAFDAVSFLPREIAQRMRERLDYIKVNPAGVLDAGCGTGDDLPLLRARFPQAPVFGVDASGGMLARAAARDTAETSWRRFLPATLTKALGHRGPRVAQADFSALPFASGAFDLLWSNFALHWHARPDLVFPEWHRVLRVDGLLMFSTLGPDTLRELRAACADAAAAAGEARAVARVIDFVDMHDLGDMLVESGFEIPVMDQETLTVTYKSPDSLLADVRRLGAYPFERGAPGYASRRLRAALYDALEARRRDDGTIPLTFEVIYGHAWKAAPRTTAEGFSIVRVQDIGKGRPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XW9</accession>
    <name>Q63XW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936117.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107046.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0421"/>
    <dbReference type="EnsemblBacteria" id="CAH34409">
        <property type="protein sequence ID" value="CAH34409"/>
        <property type="gene ID" value="BPSL0421"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0421"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1241"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWSRDVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="376" mass="40400" checksum="9D1C5E7321338952" modified="2004-10-25" version="1">MDFRHTEDRRMLADSLNRFIAEQYAFPVRDRIALSPAGYSDDMWRRFAELGAIGALFPQECGGFGGAGFDIALVFECLGRGLVVEPFVGALMAGRALAQAGGRAHLERLAALIEGRAIGAFAHAEPDTHYEPHTVRTRAARDGEGWVLDGAKAVVDCGEHATFFVVSARIAGGDDDAAGLSLFVVPRTAPGVTVRGYRKIDGGRAADMRLERAALADDACVGKPGEAADAIERAIGFGLLALAAEALGAMDVAKAHTLEYLRTRRQFGVPIGSFQALQHRMADLLLEIEQARSAVINAAAQLDAPRVARERALSAAKYSVGRIGALVAEESIQLHGGIGMTWELPLAHYAKRLVMIDHQLGDEDHHLARYAVLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XX2</accession>
    <name>Q63XX2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522925.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107043.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0418"/>
    <dbReference type="DNASU" id="3093256"/>
    <dbReference type="EnsemblBacteria" id="CAH34406">
        <property type="protein sequence ID" value="CAH34406"/>
        <property type="gene ID" value="BPSL0418"/>
    </dbReference>
    <dbReference type="GeneID" id="56527338"/>
    <dbReference type="KEGG" id="bps:BPSL0418"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1244"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PSGYGQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="33539" checksum="39AC4A5CDA1332A8" modified="2004-10-25" version="1">MDLNALTLLVDILDAGNLSKAAQRLKMSRANVSYRLNQLEKSIGLQLVRRTTRRIEPTEIGLRLYEHGRRIQSELFAAREAVTTLGQDLQGRVRLSVPSGYGQLVMSNWLIAFKRLYPGIVLDVVFENRIEDLMRDEVDIAVRVMSEPPQNLVARDMGAVRYVACASPGFAATHGMPTELGQLFDAPVITSTVVGRQLRVAAYLGDERHEVLLEPTLISENFLFLRQAILAGLGVGIVPDYVVHDDVRRGAVVTTLDAYRLSIFGTHMYMLYMPNRHHTRATSTFIDFMLEEARNAGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YL7</accession>
    <name>Q63YL7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage major capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204764.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106798.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0170"/>
    <dbReference type="EnsemblBacteria" id="CAH34157">
        <property type="protein sequence ID" value="CAH34157"/>
        <property type="gene ID" value="BPSL0170"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0170"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1552"/>
    <dbReference type="eggNOG" id="ENOG502Z7HY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HIRYNTL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006441">
        <property type="entry name" value="Phage_P2_GpN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05125">
        <property type="entry name" value="Phage_cap_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01551">
        <property type="entry name" value="major_capsid_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="336" mass="37973" checksum="7ADE7CBBAF74B5F6" modified="2004-10-25" version="1">MRKETRQAYEKYTAQIAKLNDTGDVSKKFAVEPTVQQRLETKMQESSEFLKRINILPVLELEGEKLGLSVSGPIASRTDTTKAARQPIDPTALDSNRYRCEKTDYDTAIPYRKLDMWAKFPDFQQRIRDVILNQGALDRIMIGWNGVKAAATTDRQANPLLQDVNIGWLQQYRERAAQRVLHEGKQAGKVLVGKAGDYDNLDALVMDIVSSMIDPWFQEDTGLVAICGRELLHDKYFPIVNATQAPTERLAADLIVSQKRIGNLPAVRVPFFPKRALMVTKLSNLSIYYQEGARRRTLKEVPERDRIENYESSNDAYVVEDFGCGCVAENIELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YZ8</accession>
    <name>Q63YZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type III restriction-modification system methylase</fullName>
            <ecNumber evidence="5">2.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106667.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0042"/>
    <dbReference type="REBASE" id="10392">
        <property type="entry name" value="M.BpsKORF42P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34025">
        <property type="protein sequence ID" value="CAH34025"/>
        <property type="gene ID" value="BPSL0042"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0042"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1702"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QDDRKFT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015855">
        <property type="entry name" value="TypeIII_Mtase_mKpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="123"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="670" mass="73400" checksum="9199DA17CF26C97A" modified="2004-10-25" version="1">MQKLDAASPEAQSADLVAANVERLKALFPDVVTEGPDGASVNLDALAALVGASAAAAADADEKYGLNWHGKRRARRLALTPSTGTLRPCPRESAGWASTRNLMIEGENLEVLKLLQKSYAGRVKLVYIDPPYNTGKDFVYPDNFTDSLRHYLELTGQTTGGKRVTSHTDASGRFHTDWLNMIYPRLKLARDLLTEDGVIAVHIDEHEQHALVLVMREIFGEDNELGVAVWDKRNPKGDARGIAYQHESIVLFARDAERLFERAPLKRPKRNAQRMLDAAREAVAGAATIADANAAYRGWVKSQTTLSGGEAMYDRISADGRVYRLVSMAWPNKKKAPDDYFVPLVHPVTGKPCPVPERGWRNPPATMRALIDKGLVEFGADETTQPQRIYFLDENMYENVPSVLPFGGSDDALMKSLGIPFDQPKPVEFAASIIGWCTDGDDLIVDFFGGSGTTAHAVMALNAADGGHRRYVLVQLPEPLDADSKDQKAAADFCAAQRVPFNLAELTKERLRRAAARIAAEHPGTRADLGFRVFRLDSTNVSEWDPRGDDIQQSLFAAVEHIKPNRSEEDLLYELMLKLGLDLCAPIDARMIAGKAVYMIDGAIVACFDAHIDRASTDALGEGIVGLIAEAADAREVTCVFRDSGFADDVAKVNLSAILEQHGVKRIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>H7C739</accession>
    <name>H7C739_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL2670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527590.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109266.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="H7C739"/>
    <dbReference type="STRING" id="272560.BPSL2670"/>
    <dbReference type="EnsemblBacteria" id="CAH36678">
        <property type="protein sequence ID" value="CAH36678"/>
        <property type="gene ID" value="BPSL2670"/>
    </dbReference>
    <dbReference type="GeneID" id="56528527"/>
    <dbReference type="KEGG" id="bps:BPSL2670"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2673"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="37139" checksum="36447C642277072E" modified="2012-04-18" version="1">MSTKGTILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFHETDVSDERALARIFDAHPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRVMRERAVKRIVFSSSATVYGVPERSPIDETFPLSATNPYGQTKLMAEQILRDVEAADPSWRVATLRYFNPVGAHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGVRDYIHVVDLARGHIAALDALERRDASLTVNLGTGRGYSVLEVVRAFEKASGRAVPYELVARRPGDVAECYANPAAAAETIGWKAERDLERMCADHWRWQENNPRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HT6</accession>
    <name>Q63HT6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190976.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112336.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2334"/>
    <dbReference type="MEROPS" id="C45.A01"/>
    <dbReference type="EnsemblBacteria" id="CAH39820">
        <property type="protein sequence ID" value="CAH39820"/>
        <property type="gene ID" value="BPSS2334"/>
    </dbReference>
    <dbReference type="GeneID" id="56598446"/>
    <dbReference type="KEGG" id="bps:BPSS2334"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5971"/>
    <dbReference type="eggNOG" id="COG4927">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SVNMTFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="38201" checksum="DCD74A8D028E3980" modified="2004-10-25" version="1">MKFLTPVVVTGSPHDIGRQLGELARPAMDAYIAQSGAWRAVARWRGHPFVAELRRAAEAAFPALVAELDGIAAGLGWHAQDVFVWNCRGELIHNAPDGCTTLAACTPRERMIAHNEDGDPHLRGKCMLVDVRPDGKPGFVGFYYPGSLPGHTFAASRAGLVQTINNVRIRRPAAGVPRMIAARAVLDAASLDDALRVLRDTPHASGFHHMLGCAGDARIVSVEASVARTSVLAVEGVYGHANHLIHPGGDAEAQIVTASSADRQARLAQLLPPLRGAADASALWCVLADRAGGGLPIYRDDPDDPDDENTLATALFSIGDDGVAFEVRERGRVRFQQFVPRDAQRPPVHRHERGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC1</accession>
    <name>Q63IC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative citrate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529371.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112151.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63IC1"/>
    <dbReference type="STRING" id="272560.BPSS2150"/>
    <dbReference type="EnsemblBacteria" id="CAH39634">
        <property type="protein sequence ID" value="CAH39634"/>
        <property type="gene ID" value="BPSS2150"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2150"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5721"/>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CLTPDQC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="8"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="30358" checksum="EDE412541607DC52" modified="2004-10-25" version="1">MTSSTNYRSYLYVPAHKAAVVEKAYASDADAIVLDLEDAVPATHKAAAREAAAAILAAGPAKPTYVRVNPYSSPWCRDDVAAIALPALKALRLPKCDAPQEIREVAAWLDALGSAAGIQILIESAYGVETAYQLATASPRLERIGLGESDLRADLQIGADNFTLEVCRARCVVAARAAGLAGPIQTVYHTLTDLDGLRESTLRAKSMGFVGRFAIHPSQVPVINEVFTPSADEIEAAERILDALDAAAGASSASSVFVLPDGRVVAPPLIANARVTLALAGNLRSNGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE1</accession>
    <name>Q63IE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS2131a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112131.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2131a"/>
    <dbReference type="EnsemblBacteria" id="CAH39613">
        <property type="protein sequence ID" value="CAH39613"/>
        <property type="gene ID" value="BPSS2131a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2131a"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="49" mass="5276" checksum="8B3B039C03879B6C" modified="2004-10-25" version="1">MVQCPEGGPWDTCIQNARGICGGDFDTIKQSVDNGARNLLFACKARNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ3</accession>
    <name>Q63IJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529308.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112079.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2078"/>
    <dbReference type="EnsemblBacteria" id="CAH39558">
        <property type="protein sequence ID" value="CAH39558"/>
        <property type="gene ID" value="BPSS2078"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2078"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5622"/>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGQFKLP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="115" mass="12911" checksum="D9CD8E1DBDB8535D" modified="2004-10-25" version="1">MIGLPSHTKIWLAAGVTDMRSGFNRLAAKVQTVLKRDPFSGHVFVFRGKRGDLVKVLWWSGDGMCLLMKRLERGRFVWPRADGGVVCLSQAQLSMLLEGIDWRQPVRTTEPTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IK4</accession>
    <name>Q63IK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fatty aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112068.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2065"/>
    <dbReference type="EnsemblBacteria" id="CAH39545">
        <property type="protein sequence ID" value="CAH39545"/>
        <property type="gene ID" value="BPSS2065"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2065"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6460"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AINCITT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="10"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="479" mass="50265" checksum="23194D76BB3B3EFA" modified="2004-10-25" version="1">MRRSLVTTDLVESTAEQVDAAASASASAAESWATSSGAARSRLLRGLAKALDSERQPLVDIADRETQLGVTRLNGELDRTVFQLRAFAALVEAGVPFEQLDDPAVSGGPPAGHPRLTRIRVPIGPVAMFAASNFPFAFSVLGGDTASALAAGCPVVVKAHPGHTELSRAVFELACAVLSAQQLPAGIVQMVQGTSVDVGVRLVRHPAICAVAFTGSFKGGTALQAQANVRQRPIPFYGELGSINPVVVLPTALQHQPEDLAQSLAASIAQGSGQFCTCPGLVIVRDNAEGAAFIAMLATSLAAAKPHAMLTPEIRRAYDSAINCITTLKDVHTLIRLPRDPEKAQPTPFLAVVDTQTFMRRHELREEIFGPACIVVKVATLDETVEVLQAIEGSLTATIWGAESATAGNLRLARVAMGIAGRVLFSGVPTGVAITAAQQHGGPWPASTQAFTTSVGHAALDRFLRPVALQDAPEWLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IN7</accession>
    <name>Q63IN7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529278.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112035.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2032"/>
    <dbReference type="EnsemblBacteria" id="CAH39510">
        <property type="protein sequence ID" value="CAH39510"/>
        <property type="gene ID" value="BPSS2032"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2032"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5560"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FITNGTW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="229"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="383" mass="41838" checksum="80D2EA8D26E60EA2" modified="2004-10-25" version="1">MQFTEEHEAISRTVKRFIEQEVNPHVDEWEEAGIFPAHEVFGKLGALGMLGLSKPAAYGGGGLDYSYELVMAEALGVCAAGGVPLAIGVQTNMATPALARFGSDALRDEFLAPAIAGRQVSCIGVSEPGAGSDVASIRTSARRDGDDYVISGTKLWITNGTQADWMCCLANTSDGPPHRNKSLIVVPLKSKGVHIEKKIRKIGMHSSDTAQIFFDDVRVPRRNLIGEEGQGFTYQMLQFQEERLYGAAAALVVLDRSIDETIDYTRARKIFGRPVLDHQIVHYRLAELKTEVEALRALTYRATELYVQGGDVTTLASMAKLKAGRLAREVTDSCLQFWGGMGFAWESSISRTYRDTRLFSIGGGADEVMLGIICKKLGTLPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IU2</accession>
    <name>Q63IU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205714.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111980.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1974"/>
    <dbReference type="EnsemblBacteria" id="CAH39452">
        <property type="protein sequence ID" value="CAH39452"/>
        <property type="gene ID" value="BPSS1974"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1974"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6346"/>
    <dbReference type="eggNOG" id="COG4675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVEANVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031929">
        <property type="entry name" value="CLP_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15984">
        <property type="entry name" value="Collagen_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266070" evidence="2">
        <location>
            <begin position="22"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen_mid" evidence="3">
        <location>
            <begin position="234"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="572" mass="51027" checksum="EE0736476E2256A4" modified="2004-10-25" version="1">MQKLFNKSAIAIGISTLLVLSGCGSVDGPSLSASGVKPATVGNTGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTASSPLGNILAQTGNLITATGTVVSATGNQISGTSVPGVNGATTTNLGNAVSSLGNGVQTLGNGTAAGLGTLGTSTNPLGPTLTSTSGVVSNVGNAVSSLGGVVTSIGTGPLAPLAPVTSPLGGAVGTLGSTVTQVGSGLNNVLTSAPVQQLETGVSSIINPISNVVSGTTQTIGTATGLGAPVNNLLTTVGNGLNAAGAKVSGSTNNQVVQAVGGVVSQLGNTVTSVGGLLTGGTTNPLAPITGIAGSLSGTLGANAGLNAGATQPGTTTNPLAPVTGLLGGLSGSAGGNAAAGLTAVLAPVTNVVGSLTAGVNGTVAAPSPAPTTGSTTTAPATGVVGSLTGGTTASGTSTTNLLAPVTNLIGGLLGGVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IY4</accession>
    <name>Q63IY4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529170.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111938.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1932"/>
    <dbReference type="EnsemblBacteria" id="CAH39410">
        <property type="protein sequence ID" value="CAH39410"/>
        <property type="gene ID" value="BPSS1932"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1932"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5418"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWANGTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="285"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="378" mass="40924" checksum="C699B526C8AE47BA" modified="2004-10-25" version="1">MNGILRLAFKLLVNDSAKFTALLVGITFAVFLMVEMTSLFAGILDKSSSTVINVGAKMWVMDPGVQTIASSIGMPAYVLDAVRSVDGVKYAVPIYSGGALVKLADGTYQAVTVIGLDDASLLGRPTMKAGRIEDIYAENGFIAIDDAEFPKLKNPALGTTFELNDHRGVIVGIAKVASSGLFGTPTLYTTYARATRYIPSTRYTTSYILVEPKSQRDIARIKREVAALGYRAYTKEEFMRRISDFYKYETGVGTNILLMTAISFIVGLSISGQTFYAFIIENLEKFGALKAIGAKNRELVAMILFQATFTALTGYGLGVGLCTALISVARLRLPSYAALITYGNLALAFGMVVVIAGLSSYLGVRRVLRIEPFDIFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J44</accession>
    <name>Q63J44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chemotaxis-related methyltranferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552065.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111878.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1873"/>
    <dbReference type="EnsemblBacteria" id="CAH39350">
        <property type="protein sequence ID" value="CAH39350"/>
        <property type="gene ID" value="BPSS1873"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1873"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5335"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETFFFRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="684" mass="71331" checksum="B0F626EAA6D09A23" modified="2004-10-25" version="1">MNVFDPRFHAWLSRETGIDPASLGNDFVARALAERIAATQPGAGGEAAQAGRPQPAITDEAVDAYWQCLNASADERRALIELFVVPETWFFREREAFAALARLGAQRLFAEPARALRILSAPCSTGEEPYSAAMALLDAGIDPSRFEIDALDISARAIAHAQRGRYGRNSFRGHVLGFRDLHFKAAADGWVLDERVRACVRFRQANLLDLLGCAGEPYDFVFCRNVLIYFDRDAQDRVVRIVEEQLDARGILFVGPAETGVVMRQGLASAQIPLAFAFRKPAVEAAARPGAGGVGARRGGAAPGGAANVVNAANAANAGAAAGDRVSTFGGTLRAIAHEWFFDAGWPTPEPIVRAIDGARSAFESFAASPASAQGATRFAPSEPRAQAGDAGERPAGIFARAPGAAEPGGEALARTGDAGRFATAPRANAFETGWTAAGAFSRAPDAGRARAGLFAPAPDAARAAHEEPFADAAGAARAAFDAPPGVSADAGRLAATARDAGAAPRASASLDHSFDTARPVFGTAAVAPGIAAPAFASRALSATALAGAFEADGTYAAAVDEAPLDAARRLADAGALDAAQQAVRASIEQSGPSAEAFYLLGLIADARGRGDEATDCYRKALYLEPTHYEALTHLATLLDIAGDRDGAQWLMQRARRAAQYESAASVTDTDDGEPRGTHGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J73</accession>
    <name>Q63J73_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190494.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111849.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1845"/>
    <dbReference type="EnsemblBacteria" id="CAH39321">
        <property type="protein sequence ID" value="CAH39321"/>
        <property type="gene ID" value="BPSS1845"/>
    </dbReference>
    <dbReference type="GeneID" id="56598250"/>
    <dbReference type="KEGG" id="bps:BPSS1845"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5295"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEWHINA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266495" evidence="1">
        <location>
            <begin position="25"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="298"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="624" mass="65660" checksum="C87A1EFD5FAD2750" modified="2004-10-25" version="1">MRTPTPLFAALSLLSTVAAAPAFAAAASPVSTNCGGSATPIAEIQGAGAPSPLAGQNVSIEAVVTADFGGADGFGGFFVQQADPQRRNQPGVSEGLFVYSPKARARAGELVHVTGKVEEKYGQTQLTLSGAVAVCASGQSVTPATLALPVDSPNAFAAYEGMLVRLPQTLTVTEVYELGRYGSVLLSNGRLRTPTSVVPPAQAKAVAEANARNRLILDDGSNKQNPATVPYPAPALSAANTLRAGYTAADVEGVLELRYGAWRLQPVPGARTPTFGASANPRTAAPARDPRANLRVASFNVLNYFNGDGAGGGFDDPSNRGAKNYEEFVRQDAKIVSALKALDADVIGLMEIENDGYGPLSAVRQLAAKLGENWRVVDPGSARLGGDAIAVALIYDSRKVKPIGNAATLAIDDKNRQPLAQTFRPLGGSRAVTVAVNHLKSKNCPDATGDDLDQGDGQGCWNATRSRAAAKIADWLARNPTGAPSEGVLLIGDLNSYTYEDPVRTLESRGYVNLVSSKVGSGAYSYVYNGEAGYLDHALATNALAWRVKAVHDWHINADEPIALQYTLAYKSAEQQRTYYAPDAYRSSDHDPVLIDIALADEYAAAASRRGAEMAAAHSRRPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JA4</accession>
    <name>Q63JA4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525106.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111818.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1814"/>
    <dbReference type="EnsemblBacteria" id="CAH39290">
        <property type="protein sequence ID" value="CAH39290"/>
        <property type="gene ID" value="BPSS1814"/>
    </dbReference>
    <dbReference type="GeneID" id="56529770"/>
    <dbReference type="KEGG" id="bps:BPSS1814"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5257"/>
    <dbReference type="eggNOG" id="ENOG5031GX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRFPDIG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9148" checksum="E64CB4404C812ECB" modified="2004-10-25" version="1">MKTETMLIQILESVIGVKKVTGDTRFLDIGGNSLNLVEVLKQIKAKTGVAPSPRLFFDKTRSTVAALSAEIDTLREMSSAAAPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JE9</accession>
    <name>Q63JE9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carboxymethylenebutenolidase</fullName>
            <ecNumber evidence="2">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190499.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111773.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1767"/>
    <dbReference type="ESTHER" id="burma-q62du7">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39242">
        <property type="protein sequence ID" value="CAH39242"/>
        <property type="gene ID" value="BPSS1767"/>
    </dbReference>
    <dbReference type="GeneID" id="56598194"/>
    <dbReference type="KEGG" id="bps:BPSS1767"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5198"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HIKAYVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="291" mass="31662" checksum="331FE6B6F473D43E" modified="2004-10-25" version="1">MLKPEVDSLVPHVPFSRRKFVQAALGGTFAAAVLPVSAQTITTDAAGLDVDTVQIRSGDASVPAYRAQPDGKSNLPVIVVIHEVFGVHAHIADICRRFAKLGYLAIAPDLYARQGDPSKHASIQELIDQVVSKVPDRQVIEDLDATVRWAGKNGGDLSRLGVTGFCWGGRQTWLFAEHNPHVRAAVAWYGKVAGETNEMTPFNPDDHAAQLKAPTLGLYGGKDDSISQRSLARMRERLAAAGTQAARESEIVVYPDAGHAFFADYRPSYVKADADDGWKRAIAWFRHHGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH4</accession>
    <name>Q63JH4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative outer membrane copper receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546785.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111748.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1742"/>
    <dbReference type="EnsemblBacteria" id="CAH39217">
        <property type="protein sequence ID" value="CAH39217"/>
        <property type="gene ID" value="BPSS1742"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1742"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5169"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPDYWEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010100">
        <property type="entry name" value="TonB-dep_Cu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01778">
        <property type="entry name" value="TonB-copper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="115"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="270"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="749" mass="80458" checksum="A809C5DD6ED9D847" modified="2004-10-25" version="1">MTSTFLRHAPTARGDHARRRRRAITLTVPALAAGAFHLAPAVAQTSEAVHGHGTLGASGVASRADTDAASAKSDGAVREAASAAASRTTTGAAPDATTLPTIEIVAAPESTPLVVVTDPKTPRQPLPASDGADYLKTIPGFASIRSGGTNGDPVLRGMFGSRLNILANGMPTLGACPGRMDAPTSYIAPESYDKVTLVKGPQTVLYGPGASAGTVLFERVTPRFKTPGMRFDGSVVGGSFGRNDQNVDVTAGTPDFYGRVSANHAHSQDYEDGNGRTVPSQWDKWNADAALGWTPDDNTRLELTAGTGDGYARYAGRGMDGAHFRRETFGLKFDKKHIGDVLDRIDAQVFYNEADHVMDNYTLRMPDPTSSMPMRMASEVRRRTLGARVAATLRLTDAFKLVTGVDAQSNRLDSRSAMGMQNYGDKPWNPQANMWNAGAFGELTWYASDASRVIGGARIDYAAARDKRATTGGMKMSMRNPTFDDLRSRVLPSGFVRYERDLASLPVTWYAGIGHAQRFPDYWELFSAKRGPNGSINAFSAIKPEKTTQLDIGAQYKSDKLDAWVSAYAGYVQDFILFDYATGPMGQITQATNVNAQIMGGEVGASWRPLAPWRFEGSLAYAWGRNVQSGAPLPQMPPLEARFGVEYTRGPWSAGGLWRVVAPQHRYALNEGNVVGKDFGPSAGFGVLSLHAQYNVSKTVQISVGVDNVLDKAYAEHLNLAGNAGFGYPANLPVTEPGRTAWVRLSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JL5</accession>
    <name>Q63JL5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111707.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1702"/>
    <dbReference type="EnsemblBacteria" id="CAH39175">
        <property type="protein sequence ID" value="CAH39175"/>
        <property type="gene ID" value="BPSS1702"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1702"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6004"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038440">
        <property type="entry name" value="FimV_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020011">
        <property type="entry name" value="Motility_prot_FimV_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03504">
        <property type="entry name" value="FimV_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="377" mass="37981" checksum="B506A127746B2649" modified="2004-10-25" version="1">MTLKTPRPDEQGGAPQSAGDEPSGAKPALYAWRQAFPSDAIAALDSLDMPLPPREAGAIADRPEQSQHAEPAGSRGAQSATNGLSATPPPMGAENAREGQTHGEAGSATDFEGAGSFDNDARVAPQRPEGATPRPVTAPDAMGRDEAAARAAESSPTESTRDAPRTPGAPAAESRLSTAGAGAAHSPMPDAAAAAEATAPHAATPPDAAPHDDGQTQAAPRPLDGGPQPPAAARHEAAPAHAEIPNAPLAPAAPAWAAPQPPGMSFAEPAPAEPGDVPAAPDRAPAANPPPLGVAQFGALNLDFDLELPSGPSASLPAFTPEALAKIARNKLELASEYVELGDLAGARTLLHEVIEADHADTRDEARVMLAKLADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT8</accession>
    <name>Q63JT8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SctL stator family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203202.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111634.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1626"/>
    <dbReference type="EnsemblBacteria" id="CAH39101">
        <property type="protein sequence ID" value="CAH39101"/>
        <property type="gene ID" value="BPSS1626"/>
    </dbReference>
    <dbReference type="GeneID" id="56597977"/>
    <dbReference type="KEGG" id="bps:BPSS1626"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5012"/>
    <dbReference type="eggNOG" id="COG1317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CRCEWDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012842">
        <property type="entry name" value="T3SS_SctL/SctL2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02499">
        <property type="entry name" value="HrpE_YscL_not"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="6">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="238" mass="26048" checksum="B58D1270CC6818A6" modified="2004-10-25" version="1">MAFWLKNRQIPLVDDLRIDAPHGVLRRDAFETVQALGAALDALAAERDAVLRAARDDAERIAAGARAQADALVEAARREHDSAYARGYDAGRAQAIADWHARAADSFEQERRVRDRMRERLAELVAAAVQQMVHTEDARGLFARAAQTIERVVAGASYLTVRVCDADYDAAREQFGLLADAWRRQGRNVPVDVVVEPRVARGTCVCESDFGTVDASLDTQLNAIRAALARALDDAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW9</accession>
    <name>Q63JW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilS</name>
        <name evidence="3" type="ordered locus">BPSS1595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530613.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111603.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1595"/>
    <dbReference type="EnsemblBacteria" id="CAH39070">
        <property type="protein sequence ID" value="CAH39070"/>
        <property type="gene ID" value="BPSS1595"/>
    </dbReference>
    <dbReference type="GeneID" id="56529993"/>
    <dbReference type="KEGG" id="bps:BPSS1595"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4976"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VKKLYMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014911">
        <property type="entry name" value="PilS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08805">
        <property type="entry name" value="PilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PilS" evidence="2">
        <location>
            <begin position="56"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="184" mass="19346" checksum="F727B931C6700CA5" modified="2004-10-25" version="1">MKPLAAHPAYRHEPAFCRRHRRERGASLLESIAYLGVAAIVIVGAIALLGSAFSSANTNRLAEELNAIQTGTKKLYMGQVNNYGDADLNANLIAARVFPSTLPTGNNNTVSNAWGGNVTVTGAGRTFTVQYTNVPRDVCINTLTAGGNWQTVAIGGNAPINYPVSPTNATANCADAATIVWTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JY9</accession>
    <name>Q63JY9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cellulose synthase catalytic subunit [UDP-forming]</fullName>
            <ecNumber evidence="10">2.4.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bcsA</name>
        <name evidence="13" type="ordered locus">BPSS1577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-beta-D-glucosyl](n+1) + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:19929"/>
            <dbReference type="Rhea" id="RHEA-COMP:10033"/>
            <dbReference type="Rhea" id="RHEA-COMP:10034"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Glycan metabolism; bacterial cellulose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.12" evidence="10"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528862.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111583.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1577"/>
    <dbReference type="EnsemblBacteria" id="CAH39050">
        <property type="protein sequence ID" value="CAH39050"/>
        <property type="gene ID" value="BPSS1577"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1577"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4951"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRLCYAN"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003919">
        <property type="entry name" value="Cell_synth_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01439">
        <property type="entry name" value="CELLSNTHASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03030">
        <property type="entry name" value="CelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="11">
        <location>
            <begin position="275"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="12">
        <location>
            <begin position="693"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH39050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="846" mass="93758" checksum="3453E259620569AE" modified="2004-10-25" version="1">MTARAAWGRRIGGAAARVRGWIARGLGVPAKGSSFDWLVRVFFHAPAPGRRDVVRDGLRAAILWAAAQWGVTQPRRARDWLWRAFVRAPHERRSRARDPFAWIDATLVPAFMFARRARRRVDAWLARLPWHRWGARLEHGAQRAVARRWLLPASAAAGVALWLAAGTSPLAPAGQFAFFATLAALALALRRVPGRLPTLALATFALLAMARYIWWRSTETLDLRTPVEACVGYLLYAAEAYTWLILVLGFVQTAWPLERPVARLPDDPAGWPSVDVYIPTYNEPLAVVKPTIFAAQSLDWPADKLNVYLLDDGRRPEFEAFARDAGIGYLTRDDNRHAKAGNINSALARTHGEYIAIFDCDHVPTRSFLQTTMGAFLRDPNCALVQTPHHFFSPDPFERNLGTFRRVPNEGSLFYGLVQAGNDLWNAAFFCGSCAVLKRGPLEAIGGVAIETVTEDAHTALKLHRRGYTSAYLPTVQAAGLATESLAGHIRQRARWARGMAQIFRIDNPFVGRGLGFFQRVCYGNAMLHFFYGIPRLVFLTMPIAYLFFHLYFINASALALASYVLPYMALAHVANARMQGRFRHSFWAEVYESVLAWYIALPTTLAFLSPRHGRFNVTAKGGRIDEGYVDWATSRPYLALFVLNVAAIAAGGVRLAASGGDEASTILMNVAWALYNLAMLGAALAVAREAKQVRVTHRVAMRVPATLLLADGTTAACHTKDYSAGGLGLDAVPLARIALGDTLDVCVSRGDRPFHFPVRVTRVDAAHLGVQFEPLTLEQERQLVQCTFGRADAWLDWRDARAEHDDAPLRGLKEVLSMGFEGYARMLRAATSAVRARRAADRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K00</accession>
    <name>Q63K00_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009972112.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111572.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1566"/>
    <dbReference type="EnsemblBacteria" id="CAH39039">
        <property type="protein sequence ID" value="CAH39039"/>
        <property type="gene ID" value="BPSS1566"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1566"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4931"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TPPPWWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="528" mass="55203" checksum="4ADDDD89F4BAF084" modified="2004-10-25" version="1">MNPLLSAAASEELGRTRHLGVALLVALLAAGVAYVFVHLFADLAPVGPRSAFPYLLLGVALAIALGFEFVNGFHDTANAVATVIYTHSLTPNVAVIWSGLWNFLGVMASTGAVAFGILQLLPVELILQVGHGAGFAMVFALLIAAIAWNLATWYFGLPSSSSHTLIGSIIGVGLANQLMHGPSGTSGVDWAQAAGVGQSLLLSPLVGFLCAALLLAALKALVRVPALYREPQTNEPPPFWVRCLLILTCTGVSFAHGSNDGQKGMGLIMLILIGTVPTAYALNKAVTPGETQTFIAVAHRASETLARYAGAAQPSPNPRADVEAYVQSRRLSDATLPAVRRLSDALAAEVGATGSIAKVPEGQADNVRNTMYLVSEALRLMEKTGRPALSPADRLALDDYRRQLDHATKFIPTWVKVAVAIALGLGTMVGWRRIVVTVGEKIGKQHLTYGQGASAEVVAMLTIGAADAYGLPVSTTHVLSSGVAGTMAANGSGLQWSTVRSLVLAWVLTLPASIVLAGALYWAFHALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA7</accession>
    <name>Q63KA7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111465.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1459"/>
    <dbReference type="EnsemblBacteria" id="CAH38930">
        <property type="protein sequence ID" value="CAH38930"/>
        <property type="gene ID" value="BPSS1459"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1459"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5700"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGAPMQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="28583" checksum="0F1D8C26A02C4F77" modified="2004-10-25" version="1">MRAFSPAGAPFIVSGILFVSDNAYTNAFGQPIGAPVPGWQPRPAPPRTPAQGRFCRIEPVDPGRHADDLHAAYATAADGRDWTYMSAGPFADAESYRAYLRKAAETDDPLHHAIVDLATGKAVGTFALMRADRANGAIEVGFVVYSPLLQKTCAGTEALFLLMRRVFDELGYRRFEWKCDSLNAPSRAAALRYGFTYEGLFRQAVVYKGRSRDTAWYSIVDGEWPALRSAFEQWLAAGNFDAHGRQRQSLSTLIAAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA8</accession>
    <name>Q63KA8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201008.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111464.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1458"/>
    <dbReference type="EnsemblBacteria" id="CAH38929">
        <property type="protein sequence ID" value="CAH38929"/>
        <property type="gene ID" value="BPSS1458"/>
    </dbReference>
    <dbReference type="GeneID" id="56530128"/>
    <dbReference type="KEGG" id="bps:BPSS1458"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4790"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYFTAWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="38"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="472" mass="50847" checksum="186F55F805FADBE2" modified="2004-10-25" version="1">MASTQSAPRATVPATTIDAGVISARLDRLPPTRSVWKLVALLSLGFFFELYDLLYSGYVAPGLVKGGILSATTRGLFGTTGVASFIAALFAGLFIGTIACGFLADRFGRRAVFTWSLLWYTAANVVMAFQDTAGGLNFWRFVVGLGLGVEMVTIGTYLSELVPKQIRGRAFACEQAVGFVAVPVVALLAYLLVPHAPFGLDGWRWVVLIGAHGAIFVWWIRRQLPESPRWLAQQGRLDEAERVLAALEAKVEAEYGRPLPPPAPAEPIAPRGRFADMWVPPYRRRTVMMTIFNVFQTVGFYGFANWVPTLLIKQGITVTTSLMYSSVIALAAPIGPLIGLAIADRFERKTVIVAMAGAAMIAGLLFSHASAAWLLVALGVCLTLANNIMSYSFHAYQAELFPTAIRARAVGFVYSWSRFSAIFTSFAIAAVLKGFGTPGVFVFIAGAMAIVMASIGLMGPRTKGVALEAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KB8</accession>
    <name>Q63KB8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enoyl coenzyme A hydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201022.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111454.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1446"/>
    <dbReference type="EnsemblBacteria" id="CAH38917">
        <property type="protein sequence ID" value="CAH38917"/>
        <property type="gene ID" value="BPSS1446"/>
    </dbReference>
    <dbReference type="GeneID" id="56597696"/>
    <dbReference type="KEGG" id="bps:BPSS1446"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4776"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LNWMRAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="27914" checksum="D3FE506A71A85C37" modified="2004-10-25" version="1">MRYETIEVTDDGRVATVTLARPDVRNAFNETMIAELTTAFDRIDAQPSLRAVVLAARGPAFCAGADLNWMKKMAGFSDDENRADARRLARMLDAIYRCAKPVIARVHGDAYAGGVGLVAACDIALAAEDVKFCLSEARLGLIPATIAPYVVRAMGERAARRYFATAEAFDCAKAAQLGFVHERVPADALDASVAKLADALCANGPQAVRACKALVRDVAGRALDAALIEQTADWIAKARAGAEAREGVASFLEKRTPSWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KD8</accession>
    <name>Q63KD8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194983.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111434.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38897">
        <property type="protein sequence ID" value="CAH38897"/>
        <property type="gene ID" value="BPSS1422"/>
    </dbReference>
    <dbReference type="GeneID" id="56530158"/>
    <dbReference type="KEGG" id="bps:BPSS1422"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4746"/>
    <dbReference type="eggNOG" id="COG3555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IREEAMH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018193">
        <property type="term" value="P:peptidyl-amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Asp_Arg_Hydrox" evidence="2">
        <location>
            <begin position="69"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="34356" checksum="4806B63ADB84675C" modified="2004-10-25" version="1">MRWAILFIFVACAAFTHRRGKVRHGFFRQLSDHSTFTAPLNCFAYAFSNVPNTPYIDDAHFPELAILKREWRTFRDEALALRDASRIKASGEYNDIGFNSFFRKGWKRFYLKWYDRPHPSALAHCPRSLAILSKLPSVKAAMFAQLPPGGKLGLHRDPYAGSLRYHLGLSTPNDDECAIVVDGDPYAWRDGEAVMFDETYLHWAENRTGHDRIILFCDIERPMKYRWAQAVNGAIGGVLMRAAASPNETGDRTGGLNRLFRYLYAVRRVGKRLKAWNRTVYYALKWALFGGILIAILWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KH7</accession>
    <name>Q63KH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rotamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BPSS1383a</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551812.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111395.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1383a"/>
    <dbReference type="EnsemblBacteria" id="CAH38856">
        <property type="protein sequence ID" value="CAH38856"/>
        <property type="gene ID" value="BPSS1383a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1383a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4704"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVAHETT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="244" mass="26448" checksum="BAAC3853FD8B1715" modified="2004-10-25" version="1">MKERLNVDAVRKLGQLSGRNNIGSLNADASESASGAAASDGQDDAEKSRALDRALILAHAKSSGMQSRPDVDRALQVAHETTLIDAYIDDFFSAVSVDEDDIGAAYARIKSKLGTTEYLLSILTVSGEADALRLRNQLIQGASFGELAMRFSTDASRDSGGDIGWVAQGVLSDVARNEIDAIVKSGFSMPIRGSNGYHLLYVRDKRDIVAPSLDQIREQLIELARVDKFERHLCELRGAVRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP9</accession>
    <name>Q63KP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940630.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111322.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1312"/>
    <dbReference type="EnsemblBacteria" id="CAH38783">
        <property type="protein sequence ID" value="CAH38783"/>
        <property type="gene ID" value="BPSS1312"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1312"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5525"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EPFTPRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="486" mass="52935" checksum="CA8F7281A96A7B9A" modified="2004-10-25" version="1">MPRRPGARTGDAAARAPHEKENAVAKILENVEHIVVVMFENRSFDTMLGWLYSPDAPPAHVLPPQSSPQFDGLRPEMSNPSKAGKTIAVTREALNSVIPDPQETFVNVTSQILGPSDAGTPWPPMQGFVVNYETTQTTDPGHVMQCHSVAQLPTLTALARAYAVSDAWFASVPSQTWPNRAFAHAGTSNGHVNNGAIPDPLEWDVPTIFDVLSSIGASWAVYSDTTVTPSLTHTMFPSLWKDAYAERFRRFPDFVAACGNDALPQYAFIEPSFLFEPNDQHPPHDVRAGDKFLHDIWTAIRTSPGWPRTLLVVTYDEHGGCFDHVLPPANATPPDNASNPGDEAFGFYRFGVRVPAVVVSPYIEAGTVFRSPTNVPYDHTSILATLRDWLDIPPDRMLGSARIANAPTLAQLVTRDTPRTDLPTIAAPSTDFVHPPPDAPLNDVQKSLVTGTSRRDGHDPAAGVAPLATRQHALDFFKRRAAAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KR2</accession>
    <name>Q63KR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pcaH</name>
        <name evidence="6" type="ordered locus">BPSS1300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524239.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111309.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1300"/>
    <dbReference type="EnsemblBacteria" id="CAH38770">
        <property type="protein sequence ID" value="CAH38770"/>
        <property type="gene ID" value="BPSS1300"/>
    </dbReference>
    <dbReference type="GeneID" id="56597502"/>
    <dbReference type="KEGG" id="bps:BPSS1300"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4588"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRWDIVL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03464">
        <property type="entry name" value="3_4-PCD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024756">
        <property type="entry name" value="PCDO_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012785">
        <property type="entry name" value="Protocat_dOase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12391">
        <property type="entry name" value="PCDO_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02422">
        <property type="entry name" value="protocat_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="5">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="26182" checksum="4901A5B618C014ED" modified="2004-10-25" version="1">MDSSTLAPRDWPSHPAYIHPPYRSSVKRGPTQPLIPLKETLRNQHAPVYGADDLGALDHDLTKNAAKNGEPLGERIVVTGRVLDEGGKPVRDTLVEVWQANAAGRYVHKVDQHDAPLDPNFLGAGRCLTDANGRYRFLTIKPGAYPWGNHPNAWRPNHIHFSLFGDYFGSRLVTQMYFPGDPLLALDPIFQGTPEDARERLISRFSIDTTEEGFALGYEFDIVLRGRDATPMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS4</accession>
    <name>Q63KS4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528596.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111297.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1288"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="EnsemblBacteria" id="CAH38758">
        <property type="protein sequence ID" value="CAH38758"/>
        <property type="gene ID" value="BPSS1288"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1288"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4568"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KATKNMF"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266370" description="Glutathione hydrolase proenzyme" evidence="5">
        <location>
            <begin position="32"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="573" mass="61415" checksum="637F3A803C988B72" modified="2004-10-25" version="1">MNATNRFKSTVLAALVSSALAGFLPSAPAHAKGPQQRVVLDGSAVAVADKYSADAAEEIFRQGGNAVDAAVAIAFTLAVTYPEAGNIGGGGFMTVYMGGKPYFLDYRERAPLAATKDMYLDKDGNVVKGMSLYGDRAVGVPGTVAGMWEAQKRFGKLKWKQVIAPAIRYARDGFVVDEQLAQRGVDASKEFGGKTNFDQYFSGLKAGATFKQPELAAVLARIANDGAKDFYDGKTADLIAASMKKGGGLITKQDLVQYKAVWRQPIQANWNGYRVITAPPPSSGGIGLVQLLTMKADRKADFDGVALNSPQYVHLIAEIEKRVFADRAQYLGDPDFYKVPVAQLTDAAYIAKRAAEVNPEKPSDTKSVLPGLGTSMPEKAETTHFSVVDKWGNAVSNTYTINGYFGSGVVAEGTGIVLNDEMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTVLTKDGKVALVIGTPGGSRIFTSIFQVITNLYDFKMPLKDAVGAMRFHHQLLPPNTIFWEPYHPIDGELAKGIEAKGYTLKGQDFSGDIQAIRIDGKTPEAVSDPRGRGVSRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KV2</accession>
    <name>Q63KV2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111269.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1262"/>
    <dbReference type="EnsemblBacteria" id="CAH38729">
        <property type="protein sequence ID" value="CAH38729"/>
        <property type="gene ID" value="BPSS1262"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1262"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4532"/>
    <dbReference type="eggNOG" id="ENOG5031BY6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VFRKDMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021783">
        <property type="entry name" value="DUF3348"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11828">
        <property type="entry name" value="DUF3348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="27609" checksum="6E922BF2C48ACC99" modified="2004-10-25" version="1">MMQVPQRSALGGPTLIRLLARLAHADVPPSGQSLSDRLSQWLAWTDAIALSSALSMSPPAAAAGARPAGDDPHGQGARVRASLAKAIARTGAFAAGRNGAVRVAARGAPNDAPADFTLFRHDYLSMQQAMEIDIGELRGRLRQTMAAQTPALARLAALDATMERALVARERSLFASVPKLLGAYFERLREAEQQCLAEAEAKAHANAEADAHAEVARKTAAPAPHAWLDAFRQDMQSVLLAELDIRFQPVDGLLAALRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LA9</accession>
    <name>Q63LA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111112.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1099"/>
    <dbReference type="EnsemblBacteria" id="CAH38567">
        <property type="protein sequence ID" value="CAH38567"/>
        <property type="gene ID" value="BPSS1099"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1099"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4307"/>
    <dbReference type="eggNOG" id="ENOG5033IEI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVGFNLP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="22994" checksum="0BAA3A1EF23F94F7" modified="2004-10-25" version="1">MSTLAALFVTILLLNLAPAFAPPTWMAMSWLGFSRPGDDPLLMALVAASAATSGRLMLAKASRSLVRGRWMSDADRRNVDVAKAWIERRRRVTAWALLAYAFSPLPSNYLFIAYGLTGLPLRLIGVPFFFGRLASYALWASLGQFTHDYVEPESNLGGAYLGLYFAASQLAFLALVYAFAKIDWAYLQREHKLRLRRAEKNEGGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LC1</accession>
    <name>Q63LC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111100.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1087"/>
    <dbReference type="EnsemblBacteria" id="CAH38555">
        <property type="protein sequence ID" value="CAH38555"/>
        <property type="gene ID" value="BPSS1087"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1087"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5224"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TMKYAGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="988" mass="104719" checksum="5D55CD3E128D80A1" modified="2004-10-25" version="1">MTMDNALKLRVMFDMIDNFTKPLKNVLNSNKGLAQALKQTRGELAELGKQQKAVASFREMRTGLAGTAEKLGEARTRVNGLATALRAADQPSRQMIADFEKAKQSAARLSIEHEKQSARVRELRAQLASTGIDTRQLAEHERTLRSNIAQTTAAMQTQTRQLEAMAEREKKLGAARGKMQTLQGVAGGMAIGGYAARSTGAHALGDLREALDETKKIQNERARITALGLGDQATKDAEKYVCSMKMMGVSTSDNMTLMRDALSIFADEHHAQMVMPTLAKMKFANEAMFGAEDAHANEEKFMNMLKVIELRGGTKDEATFRNEANMVQKVLSATGGRVGGDEWRNFIQTGGVAAKQMRQDAFYYQMEPLIQEMGGHQVGTGLMSAYSNVYQGKTTVRAAQEMMKLGLLDKKNVEYNKIGMIKRIKPGALLGGDLFKASPLEWLEKVLLPQMAKKGVTDPDKVKDMISTIFTNRTAANLFSTMYMQSQQIHKNEKLNKGAYGIDEMHDLASKQTPGKELDARAKLRDLLNEIGERIAPMYNAALDKTRELADRLLTTIQAHPQATKVVVALAGGFAALLAVLGTFTIVLAGVLGPLAVVRFSMATLGIQGGILSRALGIGAAAWRMFGTAAMGAGRLLLTTPIGLYAAAFAAAALLIYRYWGPIKAFVGGALTAIGDALAPIGVALRGALQPVGRALAAAKPLWNGLGGALSTVAGWLGKLFAPARASADGLSAAAAAGRGFGAVLGTVLRVALVPLTWLGRALGGLAGLFVEAMGDARAALNGGLAALGTLILNWSPLGMFYRALAGVLSLFGVELPAKFSEFGGHLIDGLVGGISSGLGKVKDAISNMANSTVGWFKEKLGIHSPSRVFAQLGGFVGEGAALGMQGEQQRIAKAALGLATVAVASFGTPALAKPMPPLVQATVPIDRRAPLAAPSAASSPAAPASPIVINIYPQAGQDPHAIARAVEAALDRRERAKQSRIGSRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LG4</accession>
    <name>Q63LG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS1048b</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009897093.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111057.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1048b"/>
    <dbReference type="EnsemblBacteria" id="CAH38512">
        <property type="protein sequence ID" value="CAH38512"/>
        <property type="gene ID" value="BPSS1048b"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1048b"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4243"/>
    <dbReference type="OMA" id="PFYERRT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="73" mass="8383" checksum="603D119F1BE34074" modified="2004-10-25" version="1">MTDFDIAQAQPRVVAPGVVEVGPFFERYMRGGYFIVKTPSGCREYHWCEQPDASDTTVMMTRDEALQLASHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M24</accession>
    <name>Q63M24_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547452.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110847.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0836"/>
    <dbReference type="EnsemblBacteria" id="CAH38298">
        <property type="protein sequence ID" value="CAH38298"/>
        <property type="gene ID" value="BPSS0836"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0836"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7113"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PMDAGWE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="16443" checksum="D35B4D2AEA057905" modified="2004-10-25" version="1">MYKKIFAALDGSRSASVALDEAIKIAETFDATVTAVCVVEHKPRLVDVDTAYVEPQDDDGSATDIATRVLADAKARLAQHRVEGSVRAIDSYGEDIAEVLMRTAAECDADLIVMGTRGRHGLRRLLLGSVAESLLRIADRPVLLRRHDEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MV3</accession>
    <name>Q63MV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-independent formaldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fdhA</name>
        <name evidence="5" type="ordered locus">BPSS0545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.46" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523135.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110566.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0545"/>
    <dbReference type="EnsemblBacteria" id="CAH38002">
        <property type="protein sequence ID" value="CAH38002"/>
        <property type="gene ID" value="BPSS0545"/>
    </dbReference>
    <dbReference type="GeneID" id="56531005"/>
    <dbReference type="KEGG" id="bps:BPSS0545"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6712"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAKAQSF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018467">
        <property type="term" value="F:formaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014184">
        <property type="entry name" value="HCHO_DH_non_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02819">
        <property type="entry name" value="fdhA_non_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="197"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="399" mass="41853" checksum="2450117771338FF2" modified="2004-10-25" version="1">MSSNRGVVYQGPGKVEVRKIDYPKMVDPSGRAIGHGVILKVVSTNICGSDQHMVRGRTTAPVGLVLGHEITGEVIEVGRDVETLKIGDLVSVPFNVACGRCAMCKEQHTGVCLNVNPARAGGAYGYVDMGGWIGGQAEYVLVPYADFNLLKFPDRDRAMAKIRDLTCLSDILPTGYHGAVTAGVKPGSTVYVAGAGPVGMAAAASARLLGAACTIVGDMNAERLAHAKAMGFEVVDLSKDATLGEQIEQILGKPEIDCAVDCVGFEAHGHGSSGHAQEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAVDVAAKHGSLSIRFGLGWAKSHSFHTGQTPVLKYSRNLMQAILFDRLPIAEIVNVAVISLDDAPEGYKKFDGGAPRKFVIDPHGMLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY6</accession>
    <name>Q63MY6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525542.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110533.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0512"/>
    <dbReference type="EnsemblBacteria" id="CAH37969">
        <property type="protein sequence ID" value="CAH37969"/>
        <property type="gene ID" value="BPSS0512"/>
    </dbReference>
    <dbReference type="GeneID" id="56531039"/>
    <dbReference type="KEGG" id="bps:BPSS0512"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6670"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELHTRNP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="120"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="257" mass="28881" checksum="0BDAC6B9FB7D4BE6" modified="2004-10-25" version="1">MMMDLEAPAAHGSADAAVAARVAVLDRARLRGEFARQDAFLYLDEFLPKDLAGRVADCARALVPEINRNYLPGHKQGGSVSRHTIDEKAPLIAELYRSKALVGFLETLTGDKLLPSPDDDPHAYALYYYTKPGDHIGWHYDTSYYDGRRYTLLFGVIDDSTSRLDYALHTRNPAVPDEPGSVQIAHGGIVFFDGDKLRHRVTPLGENEIRVSLTFEYVTDPGMRPWKRFVSNMKDAIAYFGFRQVFKQTAARRSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N88</accession>
    <name>Q63N88_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525427.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110431.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0408"/>
    <dbReference type="EnsemblBacteria" id="CAH37863">
        <property type="protein sequence ID" value="CAH37863"/>
        <property type="gene ID" value="BPSS0408"/>
    </dbReference>
    <dbReference type="GeneID" id="56531142"/>
    <dbReference type="KEGG" id="bps:BPSS0408"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6541"/>
    <dbReference type="eggNOG" id="ENOG503408R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QEIREIX"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267393" evidence="1">
        <location>
            <begin position="34"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="244" mass="24809" checksum="60DC37CA05B55D0D" modified="2004-10-25" version="1">MPLARRDRALCAFVAAPLLWGLLAGVAAAQALAQPAASTVSVCAAVITGSSGTTVDVSYAGLPGNQPKLYGDFVALWQSSVVPWSIAPAARLGIPTDAELGTVVMTGVSISATPYTVGYAVGPEVDDVCASALLAADGSTGVVDTVTLQLASVGATSLTFRYHTLSGYLPATAGNWVGLWRGRASPYNAAASVARVKVAADVTDDSVVMEGVTLSPGEIYTAIYFMGEPLTTAAVLLNFVAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ND5</accession>
    <name>Q63ND5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative chromosome condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197352.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110384.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0364"/>
    <dbReference type="EnsemblBacteria" id="CAH37812">
        <property type="protein sequence ID" value="CAH37812"/>
        <property type="gene ID" value="BPSS0364"/>
    </dbReference>
    <dbReference type="GeneID" id="56597858"/>
    <dbReference type="KEGG" id="bps:BPSS0364"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6488"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHPHRGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="5">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="6">
        <location>
            <begin position="182"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="31566" checksum="881660F3CB22ED40" modified="2004-10-25" version="1">MTIARSIQRTYPAHRTTEGGGFVVHRPFPTRLLTDFDPFLLLDEMGPVDYAPNDAKGAPDHPHRGFETVTYVLEGWFRHRDSAGHAGALGPGDVQWMTAGAGVVHSEMPDPEFARRGGRAHAFQLWVNLPRRDKMIAPRYQDIPAARIPSAKSPDGRAKVRVIAGEAFGACATIETRTPMLYLHFTLSPGAVVEQPVPAGFRVFAYPFEGGGFYGGDREAVDARHVVVYAEDGDTAVIAAGEAPLDLLLIGGAPLNEPIVRYGPFVMNTEDEIREAVADYQTGRMGRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NJ9</accession>
    <name>Q63NJ9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="2 5">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2 5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198623.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110320.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0300"/>
    <dbReference type="EnsemblBacteria" id="CAH37748">
        <property type="protein sequence ID" value="CAH37748"/>
        <property type="gene ID" value="BPSS0300"/>
    </dbReference>
    <dbReference type="GeneID" id="56597811"/>
    <dbReference type="KEGG" id="bps:BPSS0300"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6406"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LNKTQFT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="7">
        <location>
            <begin position="5"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="31759" checksum="A202502697345228" modified="2004-10-25" version="1">MKALIFPGQGAQAAGMGAGLFERFPEIVATANDVMGLSIERLCLDDPHGQLADTRYAQPAIFVVNALHLAAWRDAHDTGDGAPVWLAGHSLGEYSALLAAGVFDFRTGLEIVKRRGELFASAGGGAMAAVVGVTAAELGRRLRAAGFDDIDLANLNSAEQTVIAGPAASVDAAASMLDAGGDVTVHPLKVSGAFHSRRMTPLKPAFEAFVSRFALAEPARPVVSNVTARPYQPPGTPADYLVEQLDQPVRWRDSVRHMLRAGVDEWIELGPGRRILTRLVDAIRLEPPERHAAPQPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NL9</accession>
    <name>Q63NL9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase [NADP+]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gabD</name>
        <name evidence="6" type="ordered locus">BPSS0280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009971372.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110300.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0280"/>
    <dbReference type="EnsemblBacteria" id="CAH37727">
        <property type="protein sequence ID" value="CAH37727"/>
        <property type="gene ID" value="BPSS0280"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0280"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6377"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHKLIEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="26"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="489" mass="51737" checksum="5944F156B5781132" modified="2004-10-25" version="1">MTTAHETLALKDPALLRERAFVAGEWQAADGGATLEVRNPATGALIGTVPAMGAAETRRAIDAANAAWPAWRKKTAKERAAILRKWHDLMIAHADDLALILTTEQGKPLVEAKGEIGYAASFLEWFAEEGKRVYGDTIPTPAADKRIVVTKEPVGVCAAITPWNFPAAMITRKVGPALAAGCPIVVKPAEATPFSALAMAVLAERAGVPAGVFSVVTGEPKAIGGELTSNPIVRKLSFTGSTPVGRLLMAQCAATVKKVSLELGGNAPFIVFDDADLDAAVEGAIASKYRNSGQTCVCTNRFYVHEKVYDAFAEKLTAAVAKLKVGPGTEAGVVQGPLINGAAVRKVEAHIADALDKGARVTTGGQRHPLGHGFFEPTVLTGVTPDMKVAKEETFGPLAPLFRFSTEEEAIRYANDTEFGLAAYFYSRDIGRVWRVAEALEYGMVGINAGIISNEVAPFGGVKQSGLGREGSHYGIDDYVVIKYMCVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NM9</accession>
    <name>Q63NM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197329.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110290.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0270"/>
    <dbReference type="EnsemblBacteria" id="CAH37717">
        <property type="protein sequence ID" value="CAH37717"/>
        <property type="gene ID" value="BPSS0270"/>
    </dbReference>
    <dbReference type="GeneID" id="56597848"/>
    <dbReference type="KEGG" id="bps:BPSS0270"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6361"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTRIRNH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="32427" checksum="A5F0DFF8844DA8EF" modified="2004-10-25" version="1">MKLQQLQAFVCAAHHKSLRAAARALGVTQPAITHTIRELEAALNAELLVRSVRGVELTACGHALLPRAEQLLGDMRRTVEAVEQVRGELSGRVAIGTMPSIALTALPRAVMKFRATMPHVSLSLEEVTVPNALARLRNGELDIAAIHHIPALERDFAQLPLCSTEFVVAMREGHPLAGARRLAELLDAEWIVTVGADHFPHSVMMSMFNAHGLPLPQRLLRAPSSFAVTLGLVARSDVIGCFTKPLAAMVAPLGIRPARLDDRLPSYDLSILSRRDLLPTPAVTQFIACLRQAADETLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P45</accession>
    <name>Q63P45_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523698.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110124.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0101"/>
    <dbReference type="DNASU" id="3096920"/>
    <dbReference type="EnsemblBacteria" id="CAH37547">
        <property type="protein sequence ID" value="CAH37547"/>
        <property type="gene ID" value="BPSS0101"/>
    </dbReference>
    <dbReference type="GeneID" id="56531451"/>
    <dbReference type="KEGG" id="bps:BPSS0101"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6130"/>
    <dbReference type="eggNOG" id="COG3522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIAMSWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="449" mass="50416" checksum="795FFCB63531D64E" modified="2004-10-25" version="1">MSWHNKVVWNEGLFLLPQLFQQQERYFEYFAHKRAAVLSPFFWGFSRYEIDQESLSFGKLVFKSGAGIFPDGTPFDVPGHTPPPPPLTIAAEHQDQVIYLAVPLRLPNTEETAFDEQAGSLARYSAFEIELRDSNAIGQGPKPVQLANMRLRLLPEKELTQSWIGIALTRVKTLHADGSVALYDGDHIPPVSQYGANPLLREWATQLHGLAKLRADALATRLSGSDGRAGAAAEVADYLLLQVLNRYEPLLEHICRIREMPPVTLYRELSMLAGELSTFVRPQTRRPRPTPGYDHAQLYASIRPLVDEVHYLLNQVLIRGAQPIPLTEQPHGIRVATMLPSELAGYSSLVLAVGAQMSPDVLQQQFASQTKISHPQRLPELIRSHLPGMTMIPLPVPPRQIPFNSSYIYYELSRTGPFWEQIAQQGGLAMHIAGHFPELKLELWGVRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P82</accession>
    <name>Q63P82_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS0062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939039.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110087.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0062"/>
    <dbReference type="EnsemblBacteria" id="CAH37506">
        <property type="protein sequence ID" value="CAH37506"/>
        <property type="gene ID" value="BPSS0062"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0062"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6072"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATSNWRD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017055">
        <property type="entry name" value="Sig_transdc_His_kinase_DctB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036431">
        <property type="entry name" value="STHK_DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="414"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="643" mass="69072" checksum="9110585D10D65904" modified="2004-10-25" version="1">MRLRGIRRLHRPAAVLAVIACCVATAWLGYSVALRYYFRAHMNEVAQRSSLYALTLESQLARYESIPRIAALEPVLSRLLNDPGERALRDEANAYLNAVQKNAELSAAYVMNARGETLAASNSNEPGSFIGSNYAFRPYFADAMKRGFGRFYGVGNTTGQAGYFLAVPIRNPGQPARAPIGVVAIKASLDRYEAALTKSGDVVLLVDRDGVAFLSSVASWRYRTLTPIPAATLRKLAATRQYGDAALEPLSDTPPAPAGAGRSSTQADSAPTPELLHLSLSGGRPAWYHVVYRAAGPLGWRVAVLVDSTDDERRALFASGGVAAATALVFALIMVAWLRHSREKERQRARTALLAAQRDLERRIAERTAELTAANAALEEKVDALDAARRILRDTRDTAIQAGKLAALGQMAAGITHELNQPLAAIMTLSSNAVRMAALGRSADLTRNLELVNDLAGRMGKIVAHMKGFARHESVSREAVSISEALQQALTLIEAHRKAAKVSVRVEPVPGQGIVLASSIRIEQLLVNLLTNAIDASAAGMDNRQVVVTTDVAGDIVRISVADSGKGIPADVMPQLFEPFFTTKQTGKGLGLGLAISQAIVDEFGGRLHARNGSGVEPELGGAVFIVELHRVSRKFSSHDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PE2</accession>
    <name>Q63PE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110027.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0003"/>
    <dbReference type="EnsemblBacteria" id="CAH37446">
        <property type="protein sequence ID" value="CAH37446"/>
        <property type="gene ID" value="BPSS0003"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0003"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3906"/>
    <dbReference type="eggNOG" id="ENOG50328UR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYIVQQV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018894">
        <property type="entry name" value="DUF2471"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10616">
        <property type="entry name" value="DUF2471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="16532" checksum="D91A2689162E7896" modified="2004-10-25" version="1">MRKILYIRTVYAKQEPAMTEQDLAALSFKAAAHDMETIVRHIAERYIRQGVPLTWRLLHAVEAEALADLGFASRHDPMVRCLFDRPAELRFPETDDLVDFGQSNALPAVFSFAVAAYERAADARADTAAVPARSARASRMGRLASRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PW9</accession>
    <name>Q63PW9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL3254A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109849.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37266">
        <property type="protein sequence ID" value="CAH37266"/>
        <property type="gene ID" value="BPSL3254A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3254A"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="75" mass="7492" checksum="F8A37C5330EC1E83" modified="2004-10-25" version="1">MSFVPAADAASAFALAFVEPCFFSSCFALLLSCFAAEAAAGAEAAGAEACANTEAEANAIAAVATEAMIFFIVFP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QT6</accession>
    <name>SYL_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="1">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuS</name>
        <name type="ordered locus">BPSL2938</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535294.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109532.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QT6"/>
    <dbReference type="SMR" id="Q63QT6"/>
    <dbReference type="STRING" id="272560.BPSL2938"/>
    <dbReference type="EnsemblBacteria" id="CAH36948">
        <property type="protein sequence ID" value="CAH36948"/>
        <property type="gene ID" value="BPSL2938"/>
    </dbReference>
    <dbReference type="GeneID" id="56528259"/>
    <dbReference type="KEGG" id="bps:BPSL2938"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2342"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000151991" description="Leucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="624"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <sequence length="864" mass="96151" checksum="C389C7051142A655" modified="2004-10-25" version="1">MHERYVPADVEAAAQSDWRAADAYRSKEDANRKKFYCVSMLPYPSGKLHMGHVRNYTINDVMYRYLRMNGYNTLMPMGWDAFGMPAENAAMANGVPPAQWTYENIAYMKKQMQSMGLAIDWSREVTTCKPDYYKWNQWLFLKMLEKGVAYKKTGTVNWDPVDQTVLANEQVIDGRGWRSGALVEKREIPMYYMRITQYADELLNDLDGLGWPERVKVMQHNWIGKSFGVNFGFPYELDGEKKLLRVFTTRADTIMGVTFCAIAAEHPLAARLARDKPALQAFIDECKRGGVAEADIATMEKKGVATGFSVSHPLTGEPVEVWIGNYVLMSYGEGAVMGVPAHDERDFAFAKKYGLPIRQVIAVEGETYSTDAWQEWYGDKTRAVCVNSGKYDGLAHDAAVDAIAAELKAGGLGDKQITYRLRDWGISRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGTGNPLAKSDAFLNCTCPKCGAAAKRETDTMDTFVDSAWYFSRYAAPDAQTMVDARTDYWMPMDQYIGGIEHAILHLLYSRFWAKVMRDLGLVAFGEPAKNLLTQGMVLNETFYREDAAGKKTWYNPADVTVSFDDKGRPVGAVLKSDGQPVELGGIEKMSKSKNNGVDPQMLIDHYGADTARLFTMFAAPPEQQLEWSGAGVDGASRFLRRVWAFGFANREALAVRAPFDAAQLAEADKTLRREIHGVLKQADFDYQRLQYNTVVSAAMKMLNAIEGAKGATPAVLRETYGVLLRVLYPVVPHVTFELWKALGYADEFGPLLDAPWPKVDEAALEQAEIELVLQVNGKVRGALKVAKDASREAIEAAAVADGMFAKFAEGRPAKKIIVVPGRLVNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV7</accession>
    <name>Q63QV7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative heat shock Hsp20-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535286.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109511.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2917"/>
    <dbReference type="EnsemblBacteria" id="CAH36927">
        <property type="protein sequence ID" value="CAH36927"/>
        <property type="gene ID" value="BPSL2917"/>
    </dbReference>
    <dbReference type="GeneID" id="56528280"/>
    <dbReference type="KEGG" id="bps:BPSL2917"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2368"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TNRPAVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="139" mass="15204" checksum="422A827B44043D81" modified="2004-10-25" version="1">MSDRTELATRNEPAGTAVATPTDTEAAAAQARTAPAVDVFENRHGITLYADLPGVPREKLDVRVQDGNLTIEAEAVVPTPAGLRLRHAEIRHPRYTRSFALSPDFDVSRIDAQLRDGVLKLTIPRRDEAKPRRIEVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R17</accession>
    <name>Q63R17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphonate metabolism PhnG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phnG</name>
        <name evidence="2" type="ordered locus">BPSL2857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200521.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109451.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2857"/>
    <dbReference type="EnsemblBacteria" id="CAH36867">
        <property type="protein sequence ID" value="CAH36867"/>
        <property type="gene ID" value="BPSL2857"/>
    </dbReference>
    <dbReference type="GeneID" id="56593728"/>
    <dbReference type="KEGG" id="bps:BPSL2857"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2443"/>
    <dbReference type="eggNOG" id="COG3624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RQRWMSV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009609">
        <property type="entry name" value="Phosphonate_metab_PhnG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06754">
        <property type="entry name" value="PhnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03293">
        <property type="entry name" value="PhnG_redo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="182" mass="19476" checksum="DF8B6DA5DB62D8D5" modified="2004-10-25" version="1">MSASAVSSLHAARRDWLAVLAKIPRDELERALDRVLDGAPAPAFDWLRAPEIGLAMVRGRIGGTGDPFNLGEASVTRAALRLRGDRTNGTTGTTGADGMNGANGANRPHGATVGIAYVLGRDKRRAELVALADALLQTPERHERLRAALIEPFRARLAQARAARSGEIATTRVEFFTMVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RG3</accession>
    <name>Q63RG3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538671.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109305.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2709"/>
    <dbReference type="EnsemblBacteria" id="CAH36717">
        <property type="protein sequence ID" value="CAH36717"/>
        <property type="gene ID" value="BPSL2709"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2709"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2623"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHHLYVL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="195" mass="21305" checksum="AF867BB4BD65CF6A" modified="2004-10-25" version="1">MDINQRIARRVRALRDLRGYSLDALAERSKVSRSNISLIERAQSNPTAVVLERLANALGVSLASLFEDDRAARAASPLSRATEQPVWKDPASGYVRRSLSPAVASPLQLVEVKFPPGGRVAYDGGERNADVHQQIWLLEGEMDIASGDDTWRIAAGDCLAMRLDRPAVFFNPGRKAARYVVALAAANAVRPGWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RS7</accession>
    <name>Q63RS7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194891.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109190.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2594"/>
    <dbReference type="EnsemblBacteria" id="CAH36602">
        <property type="protein sequence ID" value="CAH36602"/>
        <property type="gene ID" value="BPSL2594"/>
    </dbReference>
    <dbReference type="GeneID" id="56594883"/>
    <dbReference type="KEGG" id="bps:BPSL2594"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2958"/>
    <dbReference type="eggNOG" id="ENOG5033IE5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGGHWEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="139" mass="15461" checksum="06BC6C7A5411866D" modified="2004-10-25" version="1">MDTLSSRVQSFMEAVMSFSLHRVVLPLVAAGAGVCALAAPLAASADEIVVEQAVPGVVVAPAMREVVVVAPSAPPPVRYEVVPEPRVGYVWDRGHWRWDHDRYVWIAGHWEVERIGMHWAPGHWSQRGPGWVWVRGHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RT4</accession>
    <name>Q63RT4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938417.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109183.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2586"/>
    <dbReference type="EnsemblBacteria" id="CAH36594">
        <property type="protein sequence ID" value="CAH36594"/>
        <property type="gene ID" value="BPSL2586"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2586"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2947"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRNPRTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="110"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="222"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="422" mass="47659" checksum="3E2EFA427BE2D67A" modified="2004-10-25" version="1">MGVEMITEAKRKIHRLSAIGVEKAKAPGYLGDGGGLYLQVSPSLTKSWIFRFKLHGRSREMGLGPYTALSLAEARKRAEDCRRLLLDGVDPIEARKGDRLQQKLQVARSMTFADCASTYIAAHRDAWKNAKHAQQWENTIETYANPVIGKLPIQDVDTNLVVRILDPIWREKPETASRLRGRIEAILNWAKTRELRRGENPARWRGHLENLLAKRSRARSVRHHPALPYEEIGAFVAELRQQEGVAARALEFTILTAARTGEVIGATLDEFDDEQRVWTVPAGRMKGERAHRVPLSPQAVRILKEMRSVTEGPSLFPGRTLDKPLSNMAMLVLLRRMGRGDLTVHGFRSTFRDWSSELTGYPREVAEAALAHAVGDQVEAAYRRGDLFAKRRQMMEAWAKYCDTPKRGGDVVPMRRKASSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW6</accession>
    <name>Q63RW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109151.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2554"/>
    <dbReference type="EnsemblBacteria" id="CAH36562">
        <property type="protein sequence ID" value="CAH36562"/>
        <property type="gene ID" value="BPSL2554"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2554"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2917"/>
    <dbReference type="eggNOG" id="ENOG502ZGYV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRTTRWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021333">
        <property type="entry name" value="DUF2946"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11162">
        <property type="entry name" value="DUF2946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="16831" checksum="A3BA18C3615C6AAF" modified="2004-10-25" version="1">MRDPARIRILRSACANCLVILRASFPEAAMKRSTRWMSLVWLALVLNVLSPVVGYARAAANAADSPFALELCSAAGAQRVVVDSGGEPRRGDASLAHVAHCVYCPGFAANLALGSSTPALPGFVRAFAYASRVERPAVFFRRGVRIAQPRAPPETVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX7</accession>
    <name>Q63RX7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">BPSL2544</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522336.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109140.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2544"/>
    <dbReference type="MEROPS" id="M01.005"/>
    <dbReference type="EnsemblBacteria" id="CAH36551">
        <property type="protein sequence ID" value="CAH36551"/>
        <property type="gene ID" value="BPSL2544"/>
    </dbReference>
    <dbReference type="GeneID" id="56528639"/>
    <dbReference type="KEGG" id="bps:BPSL2544"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2829"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKRWYSQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038438">
        <property type="entry name" value="PepN_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012779">
        <property type="entry name" value="Peptidase_M1_pepN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024601">
        <property type="entry name" value="Peptidase_M1_pepN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037144">
        <property type="entry name" value="Peptidase_M1_pepN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035414">
        <property type="entry name" value="Peptidase_M1_pepN_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322">
        <property type="entry name" value="PTHR46322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11940">
        <property type="entry name" value="DUF3458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17432">
        <property type="entry name" value="DUF3458_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02414">
        <property type="entry name" value="pepN_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="14">
        <location>
            <begin position="108"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="231"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3458" evidence="12">
        <location>
            <begin position="457"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3458_C" evidence="13">
        <location>
            <begin position="568"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH36551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="900" mass="100028" checksum="56BDB49DA6B0CD19" modified="2004-10-25" version="1">MSDIAAPNAEIRRSDYTPPAFLIDTVSLEFDLEPARTIVTNTMRVRRNPDAAPAPHFELMGEALVLIGARVDGKPHDAVRVHEHGLSVENVPDAFELTIENACAPESNTTLSGLYVSSGNFFTQCEAEGFRRITYFVDRPDVMASYTVTLRADQAAYPVLLSNGNLVDAGDLPNGRHFAKWEDPFKKPSYLFALVAGKLVKLEETIKSASGKDKLLQVWVEPQDLGKTRHAMDSLIHSIRWDERRFGLELDLDRFMIVAVGDFNMGAMENKGLNIFNTKYVLANPETATDVDFANVESVVGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSADMSAGAEDDAAARAVKRIEDVRVLRQLQFAEDAGPMAHPVRPERYVEINNFYTMTVYEKGAEVVRMYQTLFGRDGFRKGMDLYFRRHDGQAVTCDDFRHAMADANGRDLALFERWYSQAGTPRVTVRTAYDAAAKRYAVTLRQGYGDAAPAARDTQKGPLLIPFAIGLIGADGRDLPLRLEGEAAASGTTRVLELTEAEATFTFVDIDAAPLPSLLRNFSAPVIVEYDYRDDELAFLLAHDSDPFNRWEAGQRLATRALLTLASRAAAQQPLTLDDAFAAAFKRVLTDDTLSPAFRELALTLPSEAYLADQMTQADPAAVHRARQFVRRQLATALRAEWLSVYERHQTPGAYAPTPGDAGRRALKNLALAYLAELDEPADAIRLATAQYDAANNMTDRACALVALLSAAAASADAARAADRALDDFYRRFENEALVIDKWFSMQATRRGTPEHPTLDIVRKLLAHPAFNLKNPNRARSLIFGFCSANPAQFHAADGSGYAFWADQVLALDALNPQVAARLARALELWRRFTPSLREKMRDALERVAANAQSRDVREIVEKALA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S31</accession>
    <name>RIMM_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimM</name>
        <name type="ordered locus">BPSL2491</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimM family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH36497" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36497.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527496.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109086.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S31"/>
    <dbReference type="SMR" id="Q63S31"/>
    <dbReference type="STRING" id="272560.BPSL2491"/>
    <dbReference type="EnsemblBacteria" id="CAH36497">
        <property type="protein sequence ID" value="CAH36497"/>
        <property type="gene ID" value="BPSL2491"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2491"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2891"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000163270" description="Ribosome maturation factor RimM">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PRC barrel" evidence="1">
        <location>
            <begin position="148"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="229" mass="24450" checksum="0ECDEB0620F3956E" modified="2008-10-14" version="2">MAGHDSGNAKRGRSPSFGVFVRKPVERASAKGTSDGAVDSQAIRIDAAQSWPDDAVEVGAVVDAYGLKGWVKLAAHAGAGRGGDALLKARDWWLQKGAERKFARVTQAKLHGDTVVAHPDGSVDRDTALALRGARVFVRRGDFPALAADEFYWVDLIGLDVVNEAGVALGKIADMIDNGVHSIMRVEYPATGKDGRPKTGERLIPFVGVYVKAVEQAAGRVVVDWEADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SG6</accession>
    <name>Q63SG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009931260.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108950.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2357"/>
    <dbReference type="EnsemblBacteria" id="CAH36359">
        <property type="protein sequence ID" value="CAH36359"/>
        <property type="gene ID" value="BPSL2357"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2357"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3054"/>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RCEIWTR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="70" mass="7980" checksum="C21BB7B37ED9F0B2" modified="2004-10-25" version="1">MTTTLQANPQAARAAIVLSDDERQPCEIWTRVMGYHRPVSSFNVGKQGEFHERKYFRERATDEVALRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SM6</accession>
    <name>Q63SM6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550196.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108890.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2294"/>
    <dbReference type="EnsemblBacteria" id="CAH36297">
        <property type="protein sequence ID" value="CAH36297"/>
        <property type="gene ID" value="BPSL2294"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2294"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3135"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TEMPACE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="25802" checksum="E5ED5E604D770D3A" modified="2004-10-25" version="1">MRVGLFVTCVVDLMRPEIGFSALKLLKQAGCDVVVPPAQTCCGQPAYNSGERAIARDLAEKTLAEFESLDYVVVPSGSCGGMIRVHYGELFRDDPELMARYGRLRTKVYELTDFLVNVARVALEPGAFKGPVTYHDSCSGLRELGVKAQPRALLAQRGVAVAEMKDCEHCCGFGGTFAVKYGDISTAIVDEKCANVRATGAGAVVLGDLGCMLNIEGRLRRTGDRDTRVLHVAQVLAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SQ8</accession>
    <name>Q63SQ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192132.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108858.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2262"/>
    <dbReference type="EnsemblBacteria" id="CAH36265">
        <property type="protein sequence ID" value="CAH36265"/>
        <property type="gene ID" value="BPSL2262"/>
    </dbReference>
    <dbReference type="GeneID" id="56596056"/>
    <dbReference type="KEGG" id="bps:BPSL2262"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3169"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="23023" checksum="2AF1694C5B5331FB" modified="2004-10-25" version="1">MSQFFRIHPDDPQPRLVRQAAEIVRGGGVIALPTDSSYALACHLDDKDAVERVRRIRGLDDKQHLSLLVRDLSELATFAMVDNRQYRLIKSVTPGPYVFILQATKEVPRRLSHPSRKTIGLRVPAHAITLALLEALGQPLLGTTLILPPDDEPLNDPEEIRARLEKQVDLVIDGGACPREPSTVIDLTGDEPQLVRAGRGPLEPFGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TB6</accession>
    <name>Q63TB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193592.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108650.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2051"/>
    <dbReference type="EnsemblBacteria" id="CAH36052">
        <property type="protein sequence ID" value="CAH36052"/>
        <property type="gene ID" value="BPSL2051"/>
    </dbReference>
    <dbReference type="GeneID" id="56595349"/>
    <dbReference type="KEGG" id="bps:BPSL2051"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.36"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CGARLMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="88" mass="8966" checksum="BA23250739368B64" modified="2004-10-25" version="1">MARPFIVLGDKHSHGGTVTTAAAASAIHGKGIARRNDRVSCPIHGPNHIVEGDDTMIIDNEGVARDGYRTACGAVLIASQSSTGGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TK5</accession>
    <name>Q63TK5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937746.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108561.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1963"/>
    <dbReference type="EnsemblBacteria" id="CAH35962">
        <property type="protein sequence ID" value="CAH35962"/>
        <property type="gene ID" value="BPSL1963"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1963"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4111"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNGMVEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="473"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="644" mass="70271" checksum="91C44ED363606A2E" modified="2004-10-25" version="1">MSDPSITSTARREKRRAHPSQFDLLRERRFAPFFATQFMGALNDNVFKIGFTSLVTYQTAKFSGVDPKTAAFLISAIFILPFVLFSATAGQLADKYDKARLTRFVKSFEIALMAVGAAGFVTHGAPLLYLCTFMMGMHSTLFGPVKYSYLPQHLNDHELVGGNGLVEMGTFVAILIGTIVGGAAAGISGRGELLLAVCCVGIALVGRVAAAGVPATPAPQPKLAINWNPFSETWRNLKLARENRTVFLSLLGISWLWFVGATFLTSFFGFAKDVLSANPDVVTVLLATFSFGIGLGSLLCERLSRRRVEIGLVPLGSLGISVFAIELYFASHALPTQTHLLTIGEFLGHAAHWRILADLFLLAMFGGFYSVPLYALIQSRSAPTHRARIIAANNILNALFMIVSALMAMLLTKAGVSIPGIFLVTALLNVVVASYIYSLVPEFLLRFIAWALVHTFYRIRLVHAERIPDEGAALLVCNHVSYVDALVLAAASPRPIRFVMDHRIFNTRFASWAFRHAKAIPIAPRHEDPEMLARAYDACEAALREGELVCIFPEGKLTKTGDVNTFHHGVTEILTRARAPVVPMALRGLWGSVFSRHEDARWPRPVKRGVMSRLTLAVGEPIPAAAATPKALQAVVAELRGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TL6</accession>
    <name>Q63TL6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550569.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108550.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1952"/>
    <dbReference type="EnsemblBacteria" id="CAH35951">
        <property type="protein sequence ID" value="CAH35951"/>
        <property type="gene ID" value="BPSL1952"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1952"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4097"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRLRHLR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="127"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="39791" checksum="DB123D0C14E511A8" modified="2004-10-25" version="1">MTTNMSDAAGAPAASFAPERRAFLARAGGGLGLAAVGLALGAAAAPGRALAAGATATADTGAASLAGGSLRRSPAGEPEAAHGAFWPNGARLVISISMQFEAGGQPPTGADSPFPPVDFPPQVPVDLASATWFAYGYREGIPRMLDLWDRHGVKVTSHMIGEAVRRRPDLAREIVARGHEAAGHGPRWSAQYALPRDEERRFLIAAREMVETATGARPVGYNCNWLRRGPNTLPLLQELGYLYHIDDVSRDEPFIEQVNGQDFVVVPYTLRNNDILLIEGRNYSPGQFLEQIKLDFDQLYDEAATRRRMMSISAHDRISGTPQMVRAWDAFLRYAQSHPGVAFMRKDDIARHALRSPLTLREPETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TP8</accession>
    <name>IF2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">BPSL1918</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526850.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108518.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TP8"/>
    <dbReference type="SMR" id="Q63TP8"/>
    <dbReference type="STRING" id="272560.BPSL1918"/>
    <dbReference type="EnsemblBacteria" id="CAH35918">
        <property type="protein sequence ID" value="CAH35918"/>
        <property type="gene ID" value="BPSL1918"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1918"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4062"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013575">
        <property type="entry name" value="IF2_assoc_dom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08364">
        <property type="entry name" value="IF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000228178" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="475"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="484"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="509"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="530"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="584"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="620"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="484"/>
            <end position="491"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="530"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="584"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="975" mass="104765" checksum="447642414BA93A17" modified="2004-10-25" version="1">MASNNVAQFAAELKMPAGVLLEQLQAAGVQKASEDDALSETDKARLLDHLRKSHGATDGDKRKITLTRRHTSEIKQADATGKARTIQVEVRKKRTFVKRDDVSETGADQAQAQTDEQAEAELKRREEEARREAELLEKQAQELRERQERLEREEAERRAREEAAEAERRRAEEEAAAKRAAAAQAEAAQQAAAAREQAQRAQSEPAEQSAQDEARAAAERAAQREAAKKAEDAAREAADKARAEQEEIRKRREAAEAEARAIREMMNTPRRAQVKAVEPPKPAEPPAAKAAEAKGTLHKPAKPAGEAAAARPAAKKPASGAPAPAAAPAGDRTKKPGTGKSGWQDDAAKRRGIKTRGDSSGGVDRGWRGGPKGRGKHQDSASSFQAPTEPIVREVHVPETISVADLAHKMSIKASEVIKVMMKMGQMVTINQVLDQETAMIVVEELGHRALAAKLDDPEALLVEGEIGSDAEQLPRPPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETPRGVVTFLDTPGHEAFTAMRARGAKATDIVILVVAADDGVMPQTKEAISHAKAGGVPIVVAINKIDKPEANPDRVKQELVAEGVVPEEYGGDSPFVPVSAKTGAGIDDLLENVLLQAEVLELKAPVESPAKGIVIEAKLDKGKGPVATVLVQSGTLSRGDVVLAGTAYGRVRAMLDENGKPTKEAGPSIPVEIQGLSEVPGAGEEVIVLPDERKAREIALFRQGKFRDVKLAKQQAAKLESMLEQMGEGEVQNLPLIIKADVQGSQEALVQSLLKLSTDEVRVQIVHSAVGGISESDVNLATASKAVIIGFNTRADAQARKLAEANGIDIRYYNIIYDAVDEVKAAMSGMLAPEKREVVTGMVEVRQVFKVPKVGTVAGCMVTDGVVKRSSSVRVLRNNVVIFTGELDSLKRFKDDVKEVKQGFECGMSLKNFNDIVEGDQFEVFEVTEVARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TT4</accession>
    <name>Q63TT4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199468.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108482.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1883"/>
    <dbReference type="EnsemblBacteria" id="CAH35882">
        <property type="protein sequence ID" value="CAH35882"/>
        <property type="gene ID" value="BPSL1883"/>
    </dbReference>
    <dbReference type="GeneID" id="56595681"/>
    <dbReference type="KEGG" id="bps:BPSL1883"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4024"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KQSDMKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="47"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="491"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="590" mass="64592" checksum="A95A35EF5CB12D8F" modified="2004-10-25" version="1">MTAPVAPAHAHTHAPNTDGIWYASYPKGVPHDIDVTRYESLAQYFDECTTRYAQRVAFISAGARMTYAALARKAAAFASYLQSLGVKPGDRVAIMLPNTFQYPVTLFGTLKAGAIVVNVNPLYTARELAHQLKDSGAQTIIVFENFAKTLQDALPETQIKHVVVTALGDLLADGLNPKGRLINFVLKHVKKLVPAYRLPQAVRLRAALAAGAKKAPAPVALKRDDLAFLQYTGGTTGVAKGAMLTHGNLIANLLQAKAWIEDQLTGDVETVLTPLPLYHIYSLTVNAFIFLGLGGRNILIANPRDTKTMMKILRHETFTGITGINTLYNAFLDNEEFRKRDFSKLKLAMAGGMAMQRAVAERFEQVTGCPIVEGYGLTECSPIVTMNPYDAHEKRAFSGTIGLPAPSTIVRFRTEDGAWANVGEPGELCVHGPQVMRGYWQRPDETAKVIDADGWLATGDIGVMDEQGFIRLIDRKKDMILVSGFNVYPNEIEDVLVSHPGIREAAAIGIPDPVHGERIKVFVVPRDASLTVEDVLTHCRKNLTGYKMPKAVEFRDALPQTNVGKILRRALRDEELAKLANAPADPHAKH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU6</accession>
    <name>RPIA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoriboisomerase A</fullName>
            <shortName evidence="1">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpiA</name>
        <name type="ordered locus">BPSL1871</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192848.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108470.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TU6"/>
    <dbReference type="SMR" id="Q63TU6"/>
    <dbReference type="STRING" id="272560.BPSL1871"/>
    <dbReference type="EnsemblBacteria" id="CAH35870">
        <property type="protein sequence ID" value="CAH35870"/>
        <property type="gene ID" value="BPSL1871"/>
    </dbReference>
    <dbReference type="GeneID" id="56595664"/>
    <dbReference type="KEGG" id="bps:BPSL1871"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4006"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158402" description="Ribose-5-phosphate isomerase A">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <sequence length="231" mass="24203" checksum="1553F33D92550FC2" modified="2004-10-25" version="1">MTQDELKRLVGEAAARYVTENVPQGAVIGVGTGSTANCFIDALAAVKDRYRGAVSSSVATTERLKSHGIKVFDLNEIESLQVYVDGADEIDGSGAMIKGGGGALTREKIVASVAETFVCIADASKRVAVLGQFPLPVEVVPMARTAIGRRLAALGGVPVLRVKQDGAPYVTDNGNEILDVKGLRIDDPRALEAAINGWPGVVTVGLFAQRGADLCLLGTERGVETLRYAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU8</accession>
    <name>Q63TU8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937638.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108468.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1869"/>
    <dbReference type="EnsemblBacteria" id="CAH35868">
        <property type="protein sequence ID" value="CAH35868"/>
        <property type="gene ID" value="BPSL1869"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1869"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4004"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMIQAPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="327" mass="35304" checksum="5DC43456C02F5B6F" modified="2004-10-25" version="1">MTDHQPTPIRFGIVGAGSIARRFAHSIAHVRVAELSRIWARRADAAAAFCAAHGGAPCDSVDALLASDIDAVYIATLNDSHAHYARTALAAGKAVLCEKPATVNARELETVLDAAHAAKRLFMEAMKPPFYPLYRKLRAHLERDPIGEIALVRAGCASSRVPADHPVYRFEQAGGALLDIGVYEMFLAVDWLGAPLDVQTLGRVGATGVDVFASVNARHARGVSQLFCGLDVMGRGDALLAAPGGYVTIHENWWNPARATIRYADGRVVELDEPFDAGGLNYEIAHFCELLRAGELESPVMTHDHSRRMIAMTDAARAALGVRYPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TW8</accession>
    <name>Q63TW8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108448.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1849"/>
    <dbReference type="EnsemblBacteria" id="CAH35848">
        <property type="protein sequence ID" value="CAH35848"/>
        <property type="gene ID" value="BPSL1849"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1849"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2081"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HATSSCM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="15473" checksum="BC3043C5F2A329D8" modified="2004-10-25" version="1">MLSMNPLSMSGLELLRAAAAGDLPAASIAETIPMRPESVELGYVKMIARADGRHLNPLGGVHGGFAATVLDSVTGCAVHTMLDPGVGYGTVDLHVKMLRPVPRDVDLVAEGRVIHLSRNLGVAEGTLKTPDDKVVAHASATCFIQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TZ7</accession>
    <name>Q63TZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbriae assembly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108419.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1820"/>
    <dbReference type="EnsemblBacteria" id="CAH35819">
        <property type="protein sequence ID" value="CAH35819"/>
        <property type="gene ID" value="BPSL1820"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1820"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2048"/>
    <dbReference type="eggNOG" id="COG4960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AHPMATR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="17121" checksum="D100DAEC1876349E" modified="2004-10-25" version="1">MARRPDFPISRTPMILPLKLVASWTLASLALADLRTRRLATFAVALVGALYAALALAGAPGDGGFASHAALGAAAFALGAAMFRAGWIAGGDVKLAAVVFLWAGPAHAWPVAFAIGVGGLAVGAVCIAAGRAPRVLAWFAPARGVPYGVALAAGGLLAVWAPAACRLPGCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U34</accession>
    <name>Q63U34_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative iron transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556945.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108382.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1782"/>
    <dbReference type="EnsemblBacteria" id="CAH35781">
        <property type="protein sequence ID" value="CAH35781"/>
        <property type="gene ID" value="BPSL1782"/>
    </dbReference>
    <dbReference type="GeneID" id="56529468"/>
    <dbReference type="KEGG" id="bps:BPSL1782"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3890"/>
    <dbReference type="eggNOG" id="COG4114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HLDVVWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008090">
        <property type="entry name" value="Fe_iron_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03951">
        <property type="entry name" value="Fe_III_red_FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="2">
        <location>
            <begin position="82"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF_C" evidence="3">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="28705" checksum="FEE5DB0A1B5F710E" modified="2004-10-25" version="1">MSARMRATRFSTFAPAAIAHYLEHVWLGAPDACDEPALAPDGAEPADLISAASLALRRDALVGAMVALYGGDARAHARALVSQWSKYYFNLAASAGFAAALLLGRPLDMAPQRMRVALRGGMPVALLFEADALRPAQAEPASRYAALVDHLRATIDTLAALAKLSPRVLWANAGNLLDYLFEQCAHAPRAGADAAWLFGPVDSRGEANPLRLPVRRVKPCSARLPDPFRARRVCCLRNEIPGEDQLCGSCPLLLTMCDDALAKQDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U37</accession>
    <name>Q63U37_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative siderophore biosynthesis related ABC transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL1779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205070.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108379.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1779"/>
    <dbReference type="EnsemblBacteria" id="CAH35778">
        <property type="protein sequence ID" value="CAH35778"/>
        <property type="gene ID" value="BPSL1779"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1779"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3887"/>
    <dbReference type="eggNOG" id="COG4615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWADTAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005898">
        <property type="entry name" value="Cyc_pep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43553:SF11">
        <property type="entry name" value="PTHR43553:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01194">
        <property type="entry name" value="cyc_pep_trnsptr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="36"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="350"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH35778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="581" mass="62882" checksum="E2938BC3A9D0B920" modified="2004-10-25" version="1">MTDATGRLDAPPSTDSRPAVKHARRLIVALLKRSRGAFAIALAACVLNGASSVLLVATLSRALSEPQAADASLAWRFGLCAVIALVTRIVTGVLFARLSQDTMAQLREHVARRVAAAELQDVERIGAAPVQSVLTDDATNVSMLFFALPNLVMHGSIVFGCLGYLAWLSWPVCLLAVAAILVGSLGYHAGDKRAIAWLEDAGRSQDKLFGYLGALFSGAKELKLHQARSRQFVDGQLGAAIAEVRDHRRRAFSAYAIGVGWIVFLFYVFLGVAAFWPALGVRGDGPATSGYVVVFLFMLLPLDGLLNNVPTLNAARVSLERIEKLMAQFGALRTAPPPDENASHEPFDTLALRGVTHSYFHERDERMFRVGPIDLTLKPGELVFIVGGNGSGKTTLAKVLTGLYEPEGGVIELDGKPIGLAERAAYRERFSAVFNDFHLFDALLGIVDPNDAARAQADARANALVAKLSLDHKVQVVDGAFSTRALSTGQRKRLALVVAYLEDRPLYLFDEWAADQDPAFKAVFYEQLLPELRARGKTVIVISHDDRYFPIADRVLKLDNGIIVSETFGARHAALANGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UD4</accession>
    <name>Q63UD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531315.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108282.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1671"/>
    <dbReference type="EnsemblBacteria" id="CAH35670">
        <property type="protein sequence ID" value="CAH35670"/>
        <property type="gene ID" value="BPSL1671"/>
    </dbReference>
    <dbReference type="GeneID" id="56529372"/>
    <dbReference type="KEGG" id="bps:BPSL1671"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3750"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021267">
        <property type="entry name" value="DUF2844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11005">
        <property type="entry name" value="DUF2844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267573" evidence="1">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="17284" checksum="7EA1AA2A60ECB35E" modified="2004-10-25" version="1">MSTKVLTIIVGTLAMVAAVYPDLAAAALGGEPVNYEAGSQVPPHIYDVRPESASQQPYTVQRDLIQNRTEVHQYIDGNGKVFAVAWSGSAKPNLQTLLGGKLFSTMIRSQSASHHGSRHSLNQWNDDLVVQSQSHGHLFRGRAWIPSMLPQGVSPEVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UI2</accession>
    <name>Q63UI2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527092.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108234.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1618"/>
    <dbReference type="EnsemblBacteria" id="CAH35618">
        <property type="protein sequence ID" value="CAH35618"/>
        <property type="gene ID" value="BPSL1618"/>
    </dbReference>
    <dbReference type="GeneID" id="56529340"/>
    <dbReference type="KEGG" id="bps:BPSL1618"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3679"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DSEHWHM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="232" mass="26641" checksum="535CC90F7B854EA9" modified="2004-10-25" version="1">MREILETIHKKKAALLDHPVFPQLESVTLPEIKEMMRVWSPLLIHLAMTFRDINRMYYHYEKPENELEIAINDHVDVDTEHWHMMVSDIKTLGVNNRAFDCESAINVIWDDLGGPVRKYMYSLVSRARQCGSCPLLKMASMEAGEATSKVFFTTSRRLAAAYEADTGNTLRYLGAEHIDSELDHSINESVFFGEPLSADKRAQAQSIVDDHFRSFIAFLDYKYEVNKLALAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V11</accession>
    <name>Q63V11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191929.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108055.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1433"/>
    <dbReference type="EnsemblBacteria" id="CAH35435">
        <property type="protein sequence ID" value="CAH35435"/>
        <property type="gene ID" value="BPSL1433"/>
    </dbReference>
    <dbReference type="GeneID" id="56595831"/>
    <dbReference type="KEGG" id="bps:BPSL1433"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3455"/>
    <dbReference type="eggNOG" id="COG3332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFTERNM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="PTHR17985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="283" mass="30694" checksum="0A2C63FB0C932843" modified="2004-10-25" version="1">MCLIVFDWQPDTTHGPVLTLAANRDEFFRRTSAPLAWWSDAPHVLAGRDLEGGGTWLGVARDGRFAALTNYRAPFDIRAGAPTRGKLVSGFLTGENVAPLDYLANVAEKAVFYNGFTLLAGDVARGELAWYCNRPADAQPAPDAPVSVAPGVHGLSNARLDTPWPKLVGKRSALGALLTGDAAAPLDALIEMMRDTREAADDALPHTGIPLERERALSAAFIETPEYGSRGTTVLRVARDAEGRLRFDMKERCDDDGSHRIVRPGAFERAFTFDVDTGGHPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V46</accession>
    <name>Q63V46_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GerE-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108020.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1398"/>
    <dbReference type="EnsemblBacteria" id="CAH35399">
        <property type="protein sequence ID" value="CAH35399"/>
        <property type="gene ID" value="BPSL1398"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1398"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1566"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APNTVRH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="382" mass="42643" checksum="0719AE6C989F3ECF" modified="2004-10-25" version="1">MVAIRAGTRQDIDALRDVPAAIVLDEAAWPPLAPRRRDFDGVTQTPGAASRELSLFLLDLYAVASRASIGEFECRFFQLLSRYLPFDAAWTGVANHTPGGPVMHNSYLYRLPHAFFIDWKRVRDCDPLAHRTLHGAYGRAAILSVVEPGLDGRFRDWCVKYGLAQLMCVCTLDRRFGLTTFLSIYRHALNRPFTEEDARRYEDVIAHLAAALTINRAAQLTRLRSEAAASTVRAICDNFGVLHHADAGFGAVLRSEWPDWAGSRLPPAFVEHLRRRVSQPYSGDALCMRCMPVAGLFQLEVRPRSLLDRLSPRELAAIRYYGEGRSHKEVAQQMEIAPATVRHYLRCAYRKLGMHDKSQIGGVLGELDRAAEGAGAARDIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V59</accession>
    <name>Q63V59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526695.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108007.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1382"/>
    <dbReference type="EnsemblBacteria" id="CAH35382">
        <property type="protein sequence ID" value="CAH35382"/>
        <property type="gene ID" value="BPSL1382"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1382"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.94"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTQHGFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="33288" checksum="189FF35764F372DE" modified="2004-10-25" version="1">MPSFQNQDILELIDGASRARIAPEAGGRLLSWSIGDTSIVFWPDAADWSNPAKIRGGNPLLFPFLGRHRVEGRIGFWRDGEGAVRELPMHGFARDLPFRAQTDADGRGVTLTLDSSDRTRAGYPFEFRFAARYRLVDGHTLDVTLSTTNLGDTPLPHYAGHHFYFALPHVKRASAVLELPPTHRRRQLDDGSISAPEPGAPRYTLDDPAIVDRFHCLDGIPAEPVRVLMPGRRHAIEIDLNRPGSAPWYAVTTWTEAPGSDFYCVEPWLGLPDAIHNGLGLQHVAPGATQTAALRIRVTPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ5</accession>
    <name>Q63VQ5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Diacylglycerol kinase</fullName>
            <ecNumber evidence="5 18">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">BPSL1189</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 18">Cell inner membrane</location>
            <topology evidence="3 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="5 18"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107811.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1189"/>
    <dbReference type="EnsemblBacteria" id="CAH35184">
        <property type="protein sequence ID" value="CAH35184"/>
        <property type="gene ID" value="BPSL1189"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1189"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1316"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVKDMGS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14264">
        <property type="entry name" value="DAGK_IM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033718">
        <property type="entry name" value="DAGK_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAH35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="156" mass="17085" checksum="E846C7549738988D" modified="2004-10-25" version="1">MRLAPSETHEPAEPHEPLGPDDPLALPHNPYKGNRGLMRAWYALKNSYNGFRVAIREESAFRQELTLAAIMLPIAAFVPVEPASRALLIGTVLLVLIVELLNSSVETAIDRISLERHELSKRAKDLGSAAVTVALCTCLSTWGLILGPLVWRRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ7</accession>
    <name>Q63VQ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185518.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107809.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1187"/>
    <dbReference type="EnsemblBacteria" id="CAH35182">
        <property type="protein sequence ID" value="CAH35182"/>
        <property type="gene ID" value="BPSL1187"/>
    </dbReference>
    <dbReference type="GeneID" id="56595120"/>
    <dbReference type="KEGG" id="bps:BPSL1187"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.341"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="195" mass="21262" checksum="2BA3CCBFEE93144D" modified="2004-10-25" version="1">MNSVCVYCGSANGAKPVYADAARAFGRALANAGLTLVYGGGRVGLMGVIADEVIASGGRAIGVITELLYDKEVGHTGLTELHVVPDMHHRKKMMAELADAFVAMPGGAGTLEEFFEVYTWAQLGYHRKPVALYNVDAFYQPLITLLEHTVDEGFMQRTYFDALCIDAAPDALIDQLVRYRPPARDKWTFVSTQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VW3</accession>
    <name>Q63VW3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198104.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107753.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1132"/>
    <dbReference type="EnsemblBacteria" id="CAH35126">
        <property type="protein sequence ID" value="CAH35126"/>
        <property type="gene ID" value="BPSL1132"/>
    </dbReference>
    <dbReference type="GeneID" id="56595082"/>
    <dbReference type="KEGG" id="bps:BPSL1132"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.415"/>
    <dbReference type="eggNOG" id="ENOG50340Q3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIGYVCH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="10618" checksum="36063FC9164A8CC5" modified="2004-10-25" version="1">MFEPPLPSRQIDYEGFEIHVSPTPTHTDANRYAYAGYVCHPGADPRLPGHTVPFHADGEESFRSVDEALDEAVSIGRSIVDGTHPDLSVLSLVTHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VY3</accession>
    <name>Q63VY3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107733.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1112"/>
    <dbReference type="EnsemblBacteria" id="CAH35105">
        <property type="protein sequence ID" value="CAH35105"/>
        <property type="gene ID" value="BPSL1112"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1112"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1227"/>
    <dbReference type="eggNOG" id="ENOG5033A2V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRWIGRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="73" mass="7263" checksum="0230692B0EB62AB2" modified="2004-10-25" version="1">MGGFRPMRSRAAQPGKEGVMKWMLIVALCASTAGCGLAAAPCRVASAGLKIVPLVGHVAAAPTDACAGVIDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VZ2</accession>
    <name>Q63VZ2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nth</name>
        <name evidence="7" type="ordered locus">BPSL1103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185942.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107724.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1103"/>
    <dbReference type="EnsemblBacteria" id="CAH35096">
        <property type="protein sequence ID" value="CAH35096"/>
        <property type="gene ID" value="BPSL1103"/>
    </dbReference>
    <dbReference type="GeneID" id="56595050"/>
    <dbReference type="KEGG" id="bps:BPSL1103"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.452"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="214" mass="23725" checksum="A0867C85789DBE9A" modified="2004-10-25" version="1">MNATKRRAIFETLQSLNPHPTTELEYTTPFELLIAVMLSAQATDVSVNKAMRKMFPVANTPKKIVALGEEGVADYIKTIGLYRTKAKNVVAASRILLEQYGGEVPAEREALESLPGVGRKTANVVLNTAFGQPTIAVDTHIFRVANRTGLAPGKDVRAVEAALEKLTPKEFLHDAHHWLILHGRYVCKARKPECWHCAIEPLCEYRPKTPAPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VZ7</accession>
    <name>Q63VZ7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526405.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107719.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1098"/>
    <dbReference type="EnsemblBacteria" id="CAH35091">
        <property type="protein sequence ID" value="CAH35091"/>
        <property type="gene ID" value="BPSL1098"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1098"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.458"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YVYETRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="32089" checksum="EF555887B2487350" modified="2004-10-25" version="1">MRFEGSSHYVATDDLKLAVNAALTLERPLLIKGEPGTGKTMLAEEVAAALGMPLLQWHIKSTTKAQQGLYEYDAVSRLRDSQLGDERVKDIANYIVKGVLWQAFEAQHPSVLLIDEIDKADIEFPNDLLRELDRMEFHVYETRETVRARHRPLVIITSNNEKELPDAFLRRCFFHYIQFPDPSTMQKIVEVHYPGIKQDLLRAALESFFELRGVSGLKKKPSTSELLDWLKLLLAEDIPPDALRSKDQKQIVPPLAGALLKNEQDVSLFERLVYMNRHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W32</accession>
    <name>Q63W32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107684.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1061"/>
    <dbReference type="EnsemblBacteria" id="CAH35056">
        <property type="protein sequence ID" value="CAH35056"/>
        <property type="gene ID" value="BPSL1061"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1061"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1153"/>
    <dbReference type="eggNOG" id="ENOG5031DCX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVRIITI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="72" mass="8273" checksum="E088B2BAE6242A05" modified="2004-10-25" version="1">MMRFNSTVFLIDPTPRRADGEYMAHARISANRSDGREYDVCRSGDLAGFDLRADAIAHARRWAETWLEDHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W46</accession>
    <name>Q63W46_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526348.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107670.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1043"/>
    <dbReference type="EnsemblBacteria" id="CAH35039">
        <property type="protein sequence ID" value="CAH35039"/>
        <property type="gene ID" value="BPSL1043"/>
    </dbReference>
    <dbReference type="GeneID" id="56526797"/>
    <dbReference type="KEGG" id="bps:BPSL1043"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.522"/>
    <dbReference type="eggNOG" id="ENOG5031JR0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PVWKWAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266825" evidence="1">
        <location>
            <begin position="30"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="18789" checksum="D1E550BA57DA40F9" modified="2004-10-25" version="1">MNHRIARPARRWAAWATLGAAAFSTLLSGCNSLYSEGATAGAGIAGAAIASKVTSNAAVATGIGLGAVAGARAGVQYTQRVAHRYSQAQIAAAAGPLEVGGVAPWSTHHSFPIEDDEHGRVTVSRLISVGPLDCKEIVFSVDTDAKGNEAAQSGFYVATICRDGPAWKWASAEPATGRWGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WA9</accession>
    <name>Q63WA9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobT</name>
        <name evidence="11" type="ordered locus">BPSL0979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193123.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107607.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0979"/>
    <dbReference type="EnsemblBacteria" id="CAH34975">
        <property type="protein sequence ID" value="CAH34975"/>
        <property type="gene ID" value="BPSL0979"/>
    </dbReference>
    <dbReference type="GeneID" id="56596211"/>
    <dbReference type="KEGG" id="bps:BPSL0979"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.595"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWMRKCA"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="352" mass="36096" checksum="BF0169616D5C2319" modified="2004-10-25" version="1">MTTSTFSLPSVDPLDDAALRATLARIIDHKTKPPGSLGRLEALALQLGMIQRTSAPSVARPAMIVFAGDHGIAAEGVSPYPQAVTAQMVANFVAGGAAINAFSRVAGLALEIVDAGVASPLPASPQLVDAAIARGTRNFAQERAMSRDEALAALAAGAARVRHHAALGTNVIGFGEMGIANTSAAACMMSRLLDVPIDACVGRGTGLDDAGLAHKRAVLGRALERHAHAREPLDVLAAFGGFEIAMIAGAFIEAAHARMAILVDGFIATSALLVADALAPAVREYCVFSHVSNEAGHRRMLEHLGGEPLLALDLRLGEGTGAALALPLVRAAAAFVNEMASFESAGVANRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WK0</accession>
    <name>Q63WK0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185897.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107516.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0891"/>
    <dbReference type="EnsemblBacteria" id="CAH34883">
        <property type="protein sequence ID" value="CAH34883"/>
        <property type="gene ID" value="BPSL0891"/>
    </dbReference>
    <dbReference type="GeneID" id="56594732"/>
    <dbReference type="GeneID" id="66546289"/>
    <dbReference type="KEGG" id="bps:BPSL0891"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.696"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRYKFVA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="27913" checksum="D8045BAEF77E3B0B" modified="2004-10-25" version="1">MKPSTEDRWSDLRPDPDNDTPLYLQLARKLGDAIHDNRWAAGEALPSERLLAESLGVSRITARKAIALLVEQGLIRRTQGAGNFIQPRYEDPLSRLSSFSEMLKRRGFTPSSTWLSRDIQPANRDEVIQLGLSPAASVTRLKRLRLADGIVMAVENSTFPATIVPDPQAIGDSLYSYLEQRGTPIVRALQHFRAVNATDEIARQMGIAPHDALLLITRIGFTHDQRAIELTDTYCRNDYYDFVVELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WR4</accession>
    <name>Q63WR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tagatose 6-phosphate kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537930.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107452.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0828"/>
    <dbReference type="EnsemblBacteria" id="CAH34819">
        <property type="protein sequence ID" value="CAH34819"/>
        <property type="gene ID" value="BPSL0828"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0828"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.773"/>
    <dbReference type="eggNOG" id="COG4573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRHFSYS"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012062">
        <property type="entry name" value="GatZ/KbaZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08013">
        <property type="entry name" value="GatZ_KbaZ-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="498" mass="53428" checksum="ABC6840ABD698D35" modified="2004-10-25" version="1">MRGVSARAEPPRSGDHVRWLREIFEANRAGRASGIYSVCSAHRLVLEAAFEAARADESPLLVEATCNQVNHHGGYTGMTPADFRRDVDALARAAGFPARALILGGDHLGPNPWRHLAARDAMREARAMVAAYVAAGFTKIHLDASMACADDAAPLSDATIAERAAQLCAAAEEAAEAAGALPVYVIGTEVPTPGGEVSAQAGGSAADTASGAAQAAARKAAVGAAHGMAHEHGGAANLPADDARGAAAGHRGAFPQIEVTRADSVSATLAAHRDAFARHGLQHAWSRVIALVAQPGVDFDDRRVLDYDPARAAALGASILRVPSLVFEAHSTDYQTESALAALVRDHFAILKVGPALTFALREALFALTYIEDALFDDASERSQLRDVIDAAMRERPEYWAPYYRGDALAQRIARQFSYSDRIRYYWLQPAVAAALERLFVNLARRAPPETLVAQWLPDVYAACRRGELAREPLAWVRHRIREVISRYARACAMQHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WR7</accession>
    <name>Q63WR7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fur</name>
        <name evidence="5" type="ordered locus">BPSL0825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189102.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107449.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0825"/>
    <dbReference type="EnsemblBacteria" id="CAH34816">
        <property type="protein sequence ID" value="CAH34816"/>
        <property type="gene ID" value="BPSL0825"/>
    </dbReference>
    <dbReference type="GeneID" id="56596537"/>
    <dbReference type="KEGG" id="bps:BPSL0825"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.777"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QHELTTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="16831" checksum="C58C61B426EA7860" modified="2004-10-25" version="1">MASTHSLAARLSRADAFAAEHGLAWTPLRRQVYERVLAAGRPIGAYDLLTELEPQRGRVPPTTVYRALEFLVEHGFIHRIESKNAFIACCEIGKPHEGQFLICEACGDTVEIPGGDLAKQLSSSPPAHGFEVHRQVVELTGLCGQCKTKHAHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WX7</accession>
    <name>Q63WX7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204891.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107389.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0764"/>
    <dbReference type="REBASE" id="10395">
        <property type="entry name" value="BpsKORF764P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34756">
        <property type="protein sequence ID" value="CAH34756"/>
        <property type="gene ID" value="BPSL0764"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0764"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.845"/>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RKNTGTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1414" mass="158463" checksum="BA6D8B4CEA10BD7A" modified="2004-10-25" version="1">MSIARQHNEWLSLIEVSGPFLSLPVLLRVFPQGLDAHDTEMSKNVRLAFGEWEEHRQEVAIHTAWLEFVLKRTLGYPDDYLLTGQALPDGLEARVHEHGETLRPTYALKAPSETLPRMLVSVYPSSQALTKPVTGTKWKTGSPDTRMMTLLHATGVPLGLVTNGEKWLLVAAKPGETTSYITWDAGLWSEEPLTLRAFVALLGVSRFFGVTENEALPHMLAESALTQQEVTDQLGQQVLKAVEVLIQALDRIDVEQHGRFLEGIGEKDLYQAALTVMMRLVFLFSAEERGLLLLGDALYDRHYAISTLRDQLREIPDEQLLEHRHDAWSRFLATCRVIYSGVEHEVMRLPAYGGALFDPNRYPFLEGRKADTSWVDTPAAPLPINNRTVLHLLESLQFLRVRVPGGGIEPRRLSFRALDIEQIGHVYEGLLDHTAKRATSPVLGFRASAGDEIEILLDELEKHASLGEDDLIAFLKEKTGRTSAAIRRALVQASSANLLSLQSVCSASDGLYDRVKRYALLLREDSSGYPVVVQQGSVYVTSGSDRRSTGTHYTPRTLTESVVATTLVPLLYEGVDGGAEPSPERLKAPAEILRLKVCDFACGSGAFLVQACRFLSERLVEAWGIAESVRPNVPLVVPEALLSASCHSEQLLPRDPEERLALARRLVAERCLYGVDVNPMAVEMAKLSLWLITLHKNRPFTFLDHAIKCGDSLLGLHDAGQVEHFHLLPARAHRRLHDYIKDQCLEYLGVARAKREELESFTLLDTRDAQLKERLYREAEAALARVRVLGNLLVGAGLSSSGSSASRSLNVLDARLEELLLDAGAALEQSRDASSDGAEDLSHLFEKSERMLSPASAPAPRRPFHWLIEFPEVFLRPDSRGFDAIVGNPPFVGGQKITGALGTDYRDFLVLFQAEGRRGSADLCAYFFLRAATLIRERGNFGLLAVNTIAEGDTRQVALEPMLRSGLTVYAARSNFIWPGTASVAASAVHMHRGGWDGERILNGTRVSTISAFLSSEDEWSPKPLKANNNKAFIGSYVLGMGFTLSGDEAARFIARDEKNREVLFPYLNGEDLNSHPYQQPSRWVINFWDWPLSRTAEGAWSGADEREQESWLRDGRVPDDYPGRVAEDFPDLLEIVRLKVKPERASNNRAVYRERWWHFAEKRPALYHALGRGSVFCRHPEDWDATAGPCRYVMGQTQVSKFLTPCMLPNSYVFDQRVVTFADASFGFYAVLQSSVHEVWARKQAASLETRLSYTPSDAFVSFPLCTISEELERLGESFHDGRSQLLQSEDIGLTEFFNRFHRQEYAPAAMEELRRLLLGIDQLVLNAYDWGDIELRHDFRAVPYLPNNDQVRYTICEEARLEILRRLSRLNRVRFESEVAEEDSLLTLTMAQRASKTPRVRRGPSSVQGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X07</accession>
    <name>Q63X07_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107359.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0733"/>
    <dbReference type="EnsemblBacteria" id="CAH34725">
        <property type="protein sequence ID" value="CAH34725"/>
        <property type="gene ID" value="BPSL0733"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0733"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.803"/>
    <dbReference type="eggNOG" id="COG3915">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPRDQFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266405" evidence="1">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="171" mass="19030" checksum="4B782A47A6EEBF9C" modified="2004-10-25" version="1">MRGQTMRISTNWIKHLVLALLLGVTLSSYAAPFKFTVDGNIKQTNQPGRRAYVFSEAALMALPQHSITTSTSWTPKATFTGPRLSDILKAVGATGTQIEFHCVDEYTFTIPASDADKYGVILARTMNGKVLDNNNYGPLWIMYPRDQFPDELKTPISEAKFAWQIIGLTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X14</accession>
    <name>Q63X14_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107352.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0726"/>
    <dbReference type="EnsemblBacteria" id="CAH34718">
        <property type="protein sequence ID" value="CAH34718"/>
        <property type="gene ID" value="BPSL0726"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0726"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.794"/>
    <dbReference type="eggNOG" id="ENOG502ZA2H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRNWSQN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="33190" checksum="9E7F32B0BF14AFC7" modified="2004-10-25" version="1">MRARAARFACVARASGAHSAFGGGPASRRTSIDSTGATMTRHSRHAAQREAQRMMKASRELNRSAILLALSVLADSGVEHYRGSFRNRAMLAPLAASALSLAAAAHGHADGAPRRHPARDAVHLGAAAAAVAGVGFHVYNVLKRPGHLSWHNLFYGAPLGAPVALLLSGLLGAAGERLRACPEQAPRLCGLPAGRALAALVAAGLAGTVGEVALLHFRGAFHHRAMVAPLVVPPVAALLVAHAALAPARPNRWFSRAWLKATAALGIAGVGFHAYGVARQMGGWRNWAQNLLAGPPLPAPPGFSALALAGLSAVSLAEREAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X26</accession>
    <name>Q63X26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ATP-binding transmembrane ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107340.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0712"/>
    <dbReference type="EnsemblBacteria" id="CAH34705">
        <property type="protein sequence ID" value="CAH34705"/>
        <property type="gene ID" value="BPSL0712"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0712"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.779"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FREHLEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="32"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="457" mass="49127" checksum="BE54BF408DB253D6" modified="2004-10-25" version="1">MPKRPSPSAAAPSTSASPSMPAPGERAPVIALRGVSMSFAKPSGEPLPVLADIDLAVREGEILGLLGRSGSGKSTLLRIAAGLVKPTSGRVEYRGAPLDGPAAGIGVVFQTFALYPWLTVEENVELGLDAIRVPPDDAHARVTSAIELIGLDGFESAYPRELSGGMRQRVGFARALVGDPALLLMDEPFSALDVLTADTLRTDFLDLWHARQLPIDAVLMVTHNIEEAVLMCDRILVLGAHPGRILAEVPIPLAYPRNRLDPELQHIVDGIYAALTSRLGDALAAPNGKPGVPAQRLPNVSSHRLDSFVDAFVAHTRDGCAELPRLASALAMPVGDLLPLAVALHVLEFAELRDGALRLTAAGRVYAQGDAGERKRLFREHLEHFVALAAHIRQVLDERAGHQAPRERFELELLDRLNPLDAANTLRVAIDWGRFAGLYDYDDDARVFRRGEGGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XG1</accession>
    <name>Q63XG1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107204.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0576"/>
    <dbReference type="EnsemblBacteria" id="CAH34568">
        <property type="protein sequence ID" value="CAH34568"/>
        <property type="gene ID" value="BPSL0576"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0576"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1070"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTIATML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="153"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="497" mass="55765" checksum="2A847600EDFC3D34" modified="2004-10-25" version="1">MMDYQKNFLDVYGNPVIVEPHRWTIATSRGIEGLPWKGIDNAGEGFSSLCRAYVQNFLLRKSPIEALNVHRELCSFARFYKTTPGASMLAAVLGYLAQLTSKGSRWRWSRIRAFYRFFAEQRHPEFDRRALVDINRIVVGGNPKGVAVRTGDPVSGPMSREEATVWRDAILDDDDDSYSSIRERAIATLVTVLGLRPTSIVHLMECDFVQNVTIDGTPVAFALDIPRAKKRAAPRTHRRRIPIHPQLAATVQRLIELNRKLHPEPQSADVRPIIYATKPNSTFGTLGWKESSDGVSAILNRAVNRYGVVSPRTQQALIVFPTRLRRSAATALAREGYSAEHIASFLDQESLQNVTVYTDAARGTIEHLDVSLADAYAPFIDAFTGAMPKPSSKRRRRKTVSYVTDDGRLLTLGECGQERVPCRRHAPYSCYRCELFGPFSDSEHVALQSDMLARRARLGKSGSLAERRMAALIDRTIFGVSHVKLLIEEMKSEQEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XK9</accession>
    <name>Q63XK9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nitrogen regulatory IIA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107156.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63XK9"/>
    <dbReference type="STRING" id="272560.BPSL0531"/>
    <dbReference type="EnsemblBacteria" id="CAH34520">
        <property type="protein sequence ID" value="CAH34520"/>
        <property type="gene ID" value="BPSL0531"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0531"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1117"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDAPDEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006320">
        <property type="entry name" value="PTS_Nitro_regul"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01419">
        <property type="entry name" value="nitro_reg_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16881" checksum="071CA1728AF63FD7" modified="2004-10-25" version="1">MNRLAKILPLENVVIDLSVTSKKRVFEQAGLIFENQNGIARSTVTDNLFARERLGSTGLGEGVAIPHGRIKGLKHPLAAFVRLAEPIPFEAPDGQPVSLLIFLLVPEQATQAHLEILSEIAQLLSDRDTRERLHTEPDRDELHRLLTQWQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XM0</accession>
    <name>PTH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">BPSL0519</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530939.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107145.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XM0"/>
    <dbReference type="SMR" id="Q63XM0"/>
    <dbReference type="STRING" id="272560.BPSL0519"/>
    <dbReference type="EnsemblBacteria" id="CAH34509">
        <property type="protein sequence ID" value="CAH34509"/>
        <property type="gene ID" value="BPSL0519"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0519"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1128"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187711" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="201" mass="22025" checksum="6A52EBFDFED77F38" modified="2004-10-25" version="1">MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHLLEPQTYMNRSGQAVVALAHFFKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLKPPRKDEQDLINAAIERALAVMPTAIKGETERAMMQLHRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XM2</accession>
    <name>Q63XM2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fdx</name>
        <name evidence="5" type="ordered locus">BPSL0517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195247.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107143.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0517"/>
    <dbReference type="EnsemblBacteria" id="CAH34507">
        <property type="protein sequence ID" value="CAH34507"/>
        <property type="gene ID" value="BPSL0517"/>
    </dbReference>
    <dbReference type="GeneID" id="56593816"/>
    <dbReference type="KEGG" id="bps:BPSL0517"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1130"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DCCVPDD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="88" mass="9718" checksum="D0E0F1521A4BA816" modified="2004-10-25" version="1">MALMITDECINCDVCEPECPNGAISMGPEIYVIDPNKCTECVGHFDEPQCQQVCPVECIPQDPGRPETKDQLMAKYRALIAAEQKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU2</accession>
    <name>Q63XU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198002.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107073.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0448"/>
    <dbReference type="EnsemblBacteria" id="CAH34436">
        <property type="protein sequence ID" value="CAH34436"/>
        <property type="gene ID" value="BPSL0448"/>
    </dbReference>
    <dbReference type="GeneID" id="56594477"/>
    <dbReference type="KEGG" id="bps:BPSL0448"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1210"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="177" mass="18177" checksum="4B5326F403E3FFDB" modified="2004-10-25" version="1">MPNIGPTSVEACVVDITTLTLDAIVNAANASLLGGGGVDGAIHRAAGPELVKECATLGGCATGDAKLTRGYRLPAKYVIHTVGPVWRGGGHGEAELLASCYRRSLEVAAGAGCASIAFPAISCGVYRFPPADATAIAVRTVAGALAGELADARFERVVFACFSSDMLDFYRTALVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y45</accession>
    <name>Q63Y45_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936067.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106970.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0343"/>
    <dbReference type="ESTHER" id="burps-q63y45">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34332">
        <property type="protein sequence ID" value="CAH34332"/>
        <property type="gene ID" value="BPSL0343"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0343"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1337"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DSAFWGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="277" mass="30556" checksum="30DB5AA06D2125A3" modified="2004-10-25" version="1">MTNADACGHAAADRWVDTGRGRLFARCWPAPHRAHMPDDAPPIVLLHDSLGCVRMWRTFPRTLAACAGRRVIAYDRLGFGQSDPRTDALGFDFVRDEARRCFPMLRDAFGFDRFVAFGHSVGGGMAVHCAAEFASACDALITESAQAFVEDRTRAGIVDAREQFKQRDAFERLRAYHGEKARWVLDAWIDTWLSPEFAGWSLAAVLPRVTCPTLAIHGGDDEYGSALHPETIARLASGPAQIEILPGVRHVPHREREQWVAQRVAAFIGAGPHGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y85</accession>
    <name>Q63Y85_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550955.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106930.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0303"/>
    <dbReference type="EnsemblBacteria" id="CAH34292">
        <property type="protein sequence ID" value="CAH34292"/>
        <property type="gene ID" value="BPSL0303"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0303"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1386"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="224" mass="24562" checksum="EFE15248CF66B7A4" modified="2004-10-25" version="1">MRFHSSAPRPAATWIRLIRAALLAAFALTLSGCGYNAIQVQDEQVKASWSEVLNQYQRRADLVPNLVNTVKGYANQERDVLTRVTEARAQVGSIRATPELLSDPQAFAKFDAAQGQLTSSLSRLLVVSENYPQLKSDANFRDLQAQLEGTENRITVARNRYIRSVQAYNTTIRSFPSNLTAMAFGYKEKPNFSVENEAQIAKPPRVDFGTSSAPAPAPAAGASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y91</accession>
    <name>Q63Y91_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutathione reductase</fullName>
            <shortName evidence="11">GRase</shortName>
            <ecNumber evidence="11">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gor</name>
        <name evidence="14" type="ordered locus">BPSL0297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Maintains high levels of reduced glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="11"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189043.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106924.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0297"/>
    <dbReference type="EnsemblBacteria" id="CAH34286">
        <property type="protein sequence ID" value="CAH34286"/>
        <property type="gene ID" value="BPSL0297"/>
    </dbReference>
    <dbReference type="GeneID" id="56594670"/>
    <dbReference type="KEGG" id="bps:BPSL0297"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1399"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFDYVKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006324">
        <property type="entry name" value="GSHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01424">
        <property type="entry name" value="gluta_reduc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="13">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="12">
        <location>
            <begin position="337"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="453" mass="48197" checksum="BD0D241D7BB8CAE4" modified="2004-10-25" version="1">MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYSHDVEDAAGYGWTFDIGLFSWPTLIEAKDREIARLSGIYVDLLNKSGVEIHTGRATLVGAHTVDVAGRRVTARHIAVATGSRPVLPPIPGIEHAITSREALELPELPQRIAIVGGGYIAVEFAGIFNGLGVDVDLFYRGEQILRGFDDDVRHALHGEMTKQGVAIHTRATIEAIERGADGGLTLRLAEGAYGPYDAVLYATGRVANGDGLGLEAVGVARDANGAIEVDAYSATTVPSIHAIGDVTARPQLTPVATRDGMLLAANLFGGKRIAADHRYVPSAVFSQPEIATVGLTEAQARAELGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVGAHMVGRDAAEIIQGIAIAIRAGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YF0</accession>
    <name>Q63YF0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525879.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106865.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0237"/>
    <dbReference type="EnsemblBacteria" id="CAH34225">
        <property type="protein sequence ID" value="CAH34225"/>
        <property type="gene ID" value="BPSL0237"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0237"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1475"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EDDLSWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="166"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="36405" checksum="5518C43E6501F420" modified="2004-10-25" version="1">MESVDLEVLRTSARWLDEGRRALLVTVVRTWGSSPRPEGAMLAVRDDGLVVGSVSGGCIEDDLIARVQASGVAHWTRPEAVKYGVTAEEAHRFGLPCGGTIELVLEPLTPASGIAALCDALEHGRLVTRTLALATGEATLASASATDGLHFDGARLVTVHGPRYRMLVIGAGQLSRYLCQIAAGLDYQVTVCDPREAYTDAWDVPGTRIVRTMPDDTVLDMRLDRRSAVIALTHDPKLDDLALMEALKTPAFYVGALGSRRNSQARRERLREFDLSAAELARLRGPAGIYIGSRTPPEIAVSILAEVTAAKNGVSLPTILQVEGAKAAREIEANSGVACGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YG5</accession>
    <name>Q63YG5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">calB</name>
        <name evidence="8" type="ordered locus">BPSL0222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198974.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106850.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0222"/>
    <dbReference type="EnsemblBacteria" id="CAH34210">
        <property type="protein sequence ID" value="CAH34210"/>
        <property type="gene ID" value="BPSL0222"/>
    </dbReference>
    <dbReference type="GeneID" id="56594429"/>
    <dbReference type="KEGG" id="bps:BPSL0222"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1490"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RHGKRWM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="29"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="472" mass="51713" checksum="762EE71F86B766E4" modified="2004-10-25" version="1">MKNDLPGLATLDALLRDQRAAYLRAPYPSWATRADHLRALRKMLLENRDALAAAINADFGHRAKEEVLMSEIWLAKEEIDEALKHGKRWIKPKSRTMNKWLRPARAKVMPQPLGVVGIVVPWNYPVLLAAGPLICALAAGNRAIVKMSELTPRTSQLFEELISKTFARDHVAVVNGDAQIGAAFSGLPFDHLLFTGSTNVGRHVMRAAAEHLTPVTLELGGKSPVIVGPRARFDAAVDAVITGKTLNAGQTCIAPDYVLVPRGKEAEFVARARARMARLYPNLSTNPDYTSIISERHFARLQRLASEAQQAGAQLHPLTDAAPDPALRRLPPVLVTQAPDASQLMQEEIFGPLLPIVPYDTLDDAIAYVNARPRPLALYLFDEDRTTIERVMRDTISGGVTVNDTLMHIACGTLPFGGVGASGMGAYHGYDGFVTFSKMKPVLTQPRLNTRAMIAPPYGKRFAAILKLMLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YT9</accession>
    <name>Q63YT9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="8">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL0100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553740.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106726.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0100"/>
    <dbReference type="EnsemblBacteria" id="CAH34084">
        <property type="protein sequence ID" value="CAH34084"/>
        <property type="gene ID" value="BPSL0100"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0100"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1630"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALTGYHW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016221">
        <property type="entry name" value="Bifunct_regulatory_prot_Ada"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000409">
        <property type="entry name" value="Ada"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="11">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from methylphosphotriester" evidence="9">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine" evidence="9">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="364" mass="39277" checksum="7BA17422C86BC83E" modified="2004-10-25" version="1">MKQPPYPTDDARWAALVARDVDADGAFCYAVKTTGVFCRPSCASRLPRRENVSFFADTGAARAAGYRPCKRCRPEGLPRELDIVNRACAVLDAHRQDRFTLAQLSDAVHVSPFHLQRLFKRVVGVSPRQYQAAQRGAALRDALQSGAAVTRAAVDAGFNSPSRLYESVPRELGMSPSAFRRKGAGLKIDYATADTRLGVVLVAATSKGICKIAFGDAAAPLVDELRTGFANAQIAESPERIAPFIAQVDAYLNGTRRRFELPLDLAATEFQQRVWDALRRIPYGETRSYTQIAEALGAPRAVRAVASACASNPVALAIPCHRVVQKGGSLAGYRWGLPRKAALLDAEARRAAGESVESAVDHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YZ5</accession>
    <name>Q63YZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525786.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106670.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0045"/>
    <dbReference type="EnsemblBacteria" id="CAH34028">
        <property type="protein sequence ID" value="CAH34028"/>
        <property type="gene ID" value="BPSL0045"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0045"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.48"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FKSEAHF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="35828" checksum="3B061EC2BC19B02F" modified="2004-10-25" version="1">MVNGRFFTTAGESPAFRGRAWGRVVTQYFGGLDACCDGDDAFDAQLSQYEIGPMRVFTIAAPAHRIVRPVAALHDHGSDFFKLILQLSGVSEIEQRGKTFRLHSGDWSLYDPRVPYSIANLTHVEQLAIQIPRKQLGGFAVPDLHTSDVREFELKGLFSLLSSFLVSLSEQLPSLPGTTGTALSETILGLIVSTLTAQRDAQGEHVALPAVLRMRVKQYIHGHLADADLSIDRIARELRCSKRYLHRIFEEEGVTIDRYIWSSRLERCKDALDNARAAKPAISEIAFSWGFSSSAHFCRSFKQRYGMTPREFVRRRAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z08</accession>
    <name>Q63Z08_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fliO</name>
        <name evidence="6" type="ordered locus">BPSL0029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FliO/MopB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106654.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0029"/>
    <dbReference type="EnsemblBacteria" id="CAH34012">
        <property type="protein sequence ID" value="CAH34012"/>
        <property type="gene ID" value="BPSL0029"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0029"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.29"/>
    <dbReference type="eggNOG" id="COG3190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MNAVNNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03500">
        <property type="entry name" value="FliO_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="16135" checksum="9F4A7B5F55F92530" modified="2004-10-25" version="1">MNAVNHAASLASGVVVGSAAPSLGVGAVLQTLVGLAVVIGLVFGCAWLARRFGLQPQRRGGALKIVASVAVGGKESATVVEIGDTWLVLGVAPGNVRLLHTLPAGSAGVIGAPAGGGLTRSPGAPGGTAMSGTLPEGASFGARFRDAMLGEAAKRFKRDGGKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>H7C742</accession>
    <name>H7C742_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="4 6">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rmlD</name>
        <name evidence="8" type="ordered locus">BPSL2683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="4 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186608.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109279.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2683"/>
    <dbReference type="EnsemblBacteria" id="CAH36691">
        <property type="protein sequence ID" value="CAH36691"/>
        <property type="gene ID" value="BPSL2683"/>
    </dbReference>
    <dbReference type="GeneID" id="56594997"/>
    <dbReference type="KEGG" id="bps:BPSL2683"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2659"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGVWNTC"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="7">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="31613" checksum="372EA1DC447B1FAE" modified="2012-04-18" version="1">MKILVTGANGQVGWELARSLAVLGQVVPLTREQADLGRPETLARIVEDAKPDVVVNAAAYTAVDAAETDGAAANVINGEAVGVLAAATKRVGGLFVHYSTDYVFDGTKPSPYIETDPTCPVNAYGASKLLGELAVAETGGDWLTFRTTWVFAARGKNFLRTMLRLAKEREEMKIVADQFGAPTWARSIADGTAHALTTAMRERAAGAFTSGVYHMTSAGQTSWHGFADAIIASWRAAPGAAPLAVSRIVPIPASAYPVPAQRPANSVLSNKALKERFGIELPDWRYAVGLCVNDLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H7C756</accession>
    <name>H7C756_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative undecaprenyl phosphate N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186126.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109267.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2671"/>
    <dbReference type="EnsemblBacteria" id="CAH36679">
        <property type="protein sequence ID" value="CAH36679"/>
        <property type="gene ID" value="BPSL2671"/>
    </dbReference>
    <dbReference type="GeneID" id="56594801"/>
    <dbReference type="KEGG" id="bps:BPSL2671"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2672"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MCLGFLP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="368" mass="40382" checksum="A31ACD75F028B41A" modified="2012-04-18" version="1">MLSFAVGFIVSLLVTLLIVRYAHLHERFSIDNDLAGVQKFHARPVPRVGGTGILIGLVVATALLSRRYPAIAGGILGLAACGLPAFASGLIEDLTKKVTPAVRLVCTMAAAALAFALMGIAITRISVPPLDFLLGYTAISAAVTVLAVAALANAVNIIDGFNGLASMVAFMMFASLAYVAFQVGDPVVMSGSIVMMGAIMGFFIWNFPAGLIFLGDGGAYFIGFMLAELAISLVMRHREVSAWYPVLLFMYPIFETCFSIYRKKFVRGMSPGIPDGVHLHMLVYKRLMRWAVGTRAAHELTRRNSLTSPYLWLLCLVAVIPATLFWQHTIHLFAFVIVFALTYVWLYVSIVRFKSPRWMVIRKRLPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-10-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V7T3</accession>
    <name>Q3V7T3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">fliP</name>
        <name evidence="14" type="ordered locus">BPSL0030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204732.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106655.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0030"/>
    <dbReference type="EnsemblBacteria" id="CAH34013">
        <property type="protein sequence ID" value="CAH34013"/>
        <property type="gene ID" value="BPSL0030"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0030"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1716"/>
    <dbReference type="eggNOG" id="COG1338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPPNQIL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004230580" description="Flagellar biosynthetic protein FliP" evidence="13">
        <location>
            <begin position="28"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="253" mass="27120" checksum="B7AC6FA54C6FF9A9" modified="2005-10-11" version="1">MKTACLRGAARWLPAILIGLAPALACAQAAGLPAFNSAPGPNGGTTYSLSVQTMLLLTMLSFLPAMLLMMTSFTRIIIVLSLLRQAIGTASTPPSQVLVGLALFLTLFVMSPVLDRAYNDAYKPFSEGTLQMDQAVQRGTAPFKAFMLKQTRETDLALFAKISKAAPMQGPEDVPLSLLVPAFVTSELKTGFQIGFTIFIPFLIIDMVVASVLMSMGMMMVSPATVSLPFKLMLFVLVDGWQLLIGSLAQSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HU8</accession>
    <name>Q63HU8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190424.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112324.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2322"/>
    <dbReference type="EnsemblBacteria" id="CAH39808">
        <property type="protein sequence ID" value="CAH39808"/>
        <property type="gene ID" value="BPSS2322"/>
    </dbReference>
    <dbReference type="GeneID" id="56598434"/>
    <dbReference type="KEGG" id="bps:BPSS2322"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5957"/>
    <dbReference type="eggNOG" id="ENOG502ZC6H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NARTRYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266279" evidence="1">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="432" mass="46803" checksum="F84BCF660A03FD98" modified="2004-10-25" version="1">MTRRAWAILMCAAAAAMPLRAAATGDADAVNDATNAALDLADATPVAAPETARPWKFSVQDAVRWSDGRGAASSWRNQLSLEFQFAHALTPTLGVNFAMRFDRFDPLSSGAASHRDVTLVKEAYASWKPSALLALDAGRINERIGAAIGYNPTDFFKAGAVSLDVPPDPDSRHTNRLGSVAVRAQRVWDSGSIALMLSPRLASRSVPGDPFATSDLQRTNGVDRWMLVGSQRIAPAIQPQWVLYGESGQSPQFGQNLSVLLGNAVVAYAEWTGGWRPSLIGSATGGGNRDRAFRTRSAVGFTWTLPVDLSLTAELQGNSGGASASRWRALQASDAYAWGRAVRTSIAAQELPSRHGLFLMAAWRNVFVRRVDLTGFAQLDLGAGQQYWLELRRRFDKFDLAVQFLRQTGPAWSRFGAMPEASSVQVLGIFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I57</accession>
    <name>Q63I57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523344.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112215.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2213"/>
    <dbReference type="EnsemblBacteria" id="CAH39698">
        <property type="protein sequence ID" value="CAH39698"/>
        <property type="gene ID" value="BPSS2213"/>
    </dbReference>
    <dbReference type="GeneID" id="56531697"/>
    <dbReference type="KEGG" id="bps:BPSS2213"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5802"/>
    <dbReference type="eggNOG" id="COG2323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMTSFDL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="18000" checksum="1089A719B6967FBC" modified="2004-10-25" version="1">MDAVLAFFAPLFGSGAPLGAPQMAARAAAAFFIALALIRIAGRRSFGQRSPFDYVVGILLGATLSRAIVGVSPFWPTVAASLAIVLLHRALAWACVRSARLERFFVGAQRELYRNGRFDEAQMSAALITMTDIYESVRQKTGECDLSGVAAAILERNGHVSIIRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG2</accession>
    <name>Q63IG2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205733.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112110.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2111"/>
    <dbReference type="EnsemblBacteria" id="CAH39591">
        <property type="protein sequence ID" value="CAH39591"/>
        <property type="gene ID" value="BPSS2111"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2111"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5657"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SVWAIFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="414" mass="44549" checksum="7AA0C6354D96DF68" modified="2004-10-25" version="1">MKKIVVVGAGIAGLTLALTLHSRGLAVRVFEAAPRIEPLGVGLNIQPYAVRVLHELGLLETLARQSITTKEMVFFTRYGQRIYSLPLGKYGGHNFPQLSIHRGILQLALLKAATERLGPDFLVNGHSFVSCTQNRRSVNAVFSGAPGGADLVSVECDALIGADGVHSKVYRSLYPDGPRTKGNGVLMWRGVTIAPPFLTGASMVRMGVPSHGKLVVYPIRSDVNAQGDQLINWVAELDEAVYREGANAAPGNGKDFIRFFASRTFDWLDVPALLERAASPIIAMPMADRDPLPRWQTGRVTLIGDAAHPMVPVGSNGAGQAMLDAHSLGTRLAETADIEAALATYEHERRAYTSNIVLGDRLDLPDRLIQEVDCRSHGEPFSDIGEIIASDEASRLALPDYHGRPLAPTQAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG8</accession>
    <name>Q63IG8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative outer membrane porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190689.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112104.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2105"/>
    <dbReference type="EnsemblBacteria" id="CAH39585">
        <property type="protein sequence ID" value="CAH39585"/>
        <property type="gene ID" value="BPSS2105"/>
    </dbReference>
    <dbReference type="GeneID" id="56598126"/>
    <dbReference type="KEGG" id="bps:BPSS2105"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5649"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWHLSLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017733">
        <property type="entry name" value="OmpA/MotB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03350">
        <property type="entry name" value="type_VI_ompA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="306"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="47347" checksum="EE72CD265843B522" modified="2004-10-25" version="1">MNTSSDSFSAGSGGFVPPNPGGAHPAAAPAAGAAAFQPRPGRWAASGTNPLVAAANPLLNLVPQIRSTVHHPNPAWLREHLVVEIRQFEERAQQAGVASEAIIGARYCLCTALDEAAALTPWGGSVWSSHSLLVSFHNETWGGEKFFHLLERLSQQPRQHLDLLELLYFCLALGFEGRYRVLDNGRAQLDAVRRQLAQTIRSVRGEFDPALSPHWRDVVTRDVTRRFTVPLWVCVALALLVGFGVFAGLRIALAGHSDRLFASIDALHVPKLQPAPPAPHPAPAPRVAKFLEPEIAAGLVSVRDEADRSVIVLRGDGLFGSGSTSVIDRYMPVLTRVADALNQVQGNVRVSGYTDDTPVHTARFASNWDLSRERAQAVRSLIAARLDRPERITAEGRGTLDPVAPNDSPANRARNRRVEITLMLAPGSDAARATKEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63II7</accession>
    <name>Q63II7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552177.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112085.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2084"/>
    <dbReference type="EnsemblBacteria" id="CAH39564">
        <property type="protein sequence ID" value="CAH39564"/>
        <property type="gene ID" value="BPSS2084"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2084"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5627"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFFDRDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266471" evidence="1">
        <location>
            <begin position="26"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="413" mass="46486" checksum="7FFE965DCD8B9580" modified="2004-10-25" version="1">METLKKLRGTVLLPMIAMVLLNANAAPLVINTDTSDQAVKAAFDAAVNDFKIENPDVQVKVNRFDHDAYKTAIRNFLTADSPDVVNWYPGRKMEPFVRAGLFEDVSDIWTKYNLDTKLKSALSAMTLNGKKWGIPYTYYQWGIYYRKDIFSKFGIEPPNTWQELLDACAKLKANGVAPFVIGTKEPWPNLAWFDYLNLRVNGFAFHMALTGGKVSFKDPRVRAVFDRWDQLTKPGYFMTNHASYTWQEAAALLAQGKGAMYLMGNFVVAPMKQAGLDAEKLGFMPFPIIDPSIPRAEEAPIESIHIPTNAKNKADARRFLAYMARADVQAKYGERTEELPVNQDAPPPSDPYLKAGAALLAKAQALSQFFDRDASPELTQAAMDAFERYMLKPDTRAAALDRLEQVRQRVYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ0</accession>
    <name>Q63IJ0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS2081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546333.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112082.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2081"/>
    <dbReference type="EnsemblBacteria" id="CAH39561">
        <property type="protein sequence ID" value="CAH39561"/>
        <property type="gene ID" value="BPSS2081"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2081"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6469"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WEGIYFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="9">
        <location>
            <begin position="26"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="8">
        <location>
            <begin position="617"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="449"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="723" mass="81195" checksum="CFA545CF82767FC0" modified="2004-10-25" version="1">MFDTKLIRLTGSNLSIALEKSADMPPVWRYFGAKLEPHAIAWSADDVRPHPPTLLDGDPPFTAFSTHGFGWFHQPALVGSRPGDVGDIDWAQSFRLDEVSTNDHSVTMKLSDEQAELGAILSYTIDPASDVITMWAELENRGATPFRVDWLAAATVPLPPDANRALSFSGRWTLEFQENREILGSATWRRDNRRGRTSHDSFPGVMVGSSLADNVGTVYGAHLGWSGNHTIIIEPMTDGRRQLQLGEWLAPGEVVLAPDQRYRTPCAFLSYSEQGLNGLSAQFHRFVRAKVLRWPRQRMQPRPVILNTWEAVYCDHDLEDLKELATAGAQIGIERFVLDDGWFHCRDNDRAGLGDWWPDANKYSRGLTPLIHHVRDLDMDFGLWIEPEMVNPDSELYRARPEWTLRLDGRPLVTGRNQLVLDLAEPDVREYLFTQISALLRDNAISYLKWDMNRDLATAGHRGMPAYRRQTQAFYALLDRLRAAFPAVEIESCASGGGRADYGVLARMHRLWTSDCNDALTRIGIQRGFLRFFPPELMGAHIGADRSHTTGRRHTLAFRAAVALFGHLGVEVDPRAMPADEIEALMRWIAIYKEWRPVLHAGTLHQGCISEALSWTQAVSDDGSASLLAIYRLREDNARYATPLKIKGLRCDIAYRVQTLYAPVAPHFVKQTQMFKMMQNEGVVISGASLLELGMPIPPMPPESAVVISLKPASELSKPLDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IL4</accession>
    <name>Q63IL4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556461.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112058.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2056"/>
    <dbReference type="EnsemblBacteria" id="CAH39534">
        <property type="protein sequence ID" value="CAH39534"/>
        <property type="gene ID" value="BPSS2056"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2056"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5596"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNDETMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="3">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="734" mass="82012" checksum="36B959972DBDD9F5" modified="2004-10-25" version="1">MSRVFTLDSPHGDGLKFHTLDGSDELGRLFEFRIEALADSHSLSLKDLLGKPVTVRIEQQGQSTRYLNGIVARASLAGRRAERYYGYELLVRPWLWLATRRSDCRIFQNKTVPEIVQEVLSTYGFPIENHLAESYVPREYCVQYNGTDAAFVSRLMEFEGIYYWFRHAEDTHTLMLSDAMSSHTALPGYETIPYIARDRTVIADVEHIDGWLPARQVSVGKHQTTDYDYTKPRADLSSQKVDPRGHDHDSFASFEWQGGYRDDAPGAHYSRVRLEEQQAEHERASADTDVRGAAPGYLFTLAHCPRADRNREYLIVRCQYRFQENAYASDQGTEAVVHQTMMLVRPSSLPYRPPRETPRPRTNEPQTATVVGPPGEEIWTDQYGRVKLQFRWDRYGQSNQDSSCWVRVSSPWAGGGFGGVQIPRVGDEVVVDFLNGDPDEPIVTGRVYNGEKMPPWGLPESATQSGLLSRSSPGGTTEHANAFRFEDKKGAEQLWMHAERNFDAETEADHSLSIEHDHTHTVGNDETMQVRNNRQRSVGQGETVNIGRHRVAQIKGNETQGVVGDRTRTVGKKETVTIVSDREATIGGNHMETVVKDKTESIGEGKTLNVVKHYQTNSKSMKTTVAEHHVEEIGERTSTIAHAHKLTVRGEHAVSVGANHTTNVQHQVLVNAGDQRALVCGKSSVLMKSDGTILIQGVNVESSGSDSHSVRGKKVTTSASVEHTVEGTVLKLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IL8</accession>
    <name>Q63IL8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative activator/secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS2052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPS (TC 1.B.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112054.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63IL8"/>
    <dbReference type="STRING" id="272560.BPSS2052"/>
    <dbReference type="EnsemblBacteria" id="CAH39530">
        <property type="protein sequence ID" value="CAH39530"/>
        <property type="gene ID" value="BPSS2052"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2052"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6446"/>
    <dbReference type="eggNOG" id="COG2831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MASIMTI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005565">
        <property type="entry name" value="Hemolysn_activator_HlyB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035251">
        <property type="entry name" value="ShlB_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027282">
        <property type="entry name" value="TPS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17287">
        <property type="entry name" value="POTRA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03865">
        <property type="entry name" value="ShlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029745">
        <property type="entry name" value="FhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266897" evidence="8">
        <location>
            <begin position="26"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="589" mass="64255" checksum="C3E9174999E369F6" modified="2004-10-25" version="1">MASIMTIKRLPIAPLSALVMFSAQAQQIPTPNDQAAAARANAEQNQQAQQRRDAQQRDATVQAPGVRSDVPRPEAYPVLPTETPCFQIDRFALDVPDSLPAASKAQGASALPMDRFAFARDWLAHYAGQCIGKQGVDLIVKGLSQAILARGYITTRVLVPEQDLSTGALKLALIPGVIRHVRFEDEKLLGTWKTAFPTRDGDVLNLRDIEQGLEQMKRVSSQDVSMRIAPGDMPGESDVVLDVKRGKPWTVVASIDNSGTRATGKLQGNVSLGIDNPLGLNDIFNVGFNQDLEFGDKRFGSHGWNAFYSIPWGYWTGTLSAYTSTYFQPLAAVNQTFVASGNMKTVDFRLNRVLTRSRNDVLGAQVRLTRRFGDSYIEGTTIPSSHQNATFLEFGLNDRHYFGSSQFDGSLAYRQGLGWLGSTDSMFAAEGGQTYRFKMVVLDANLSTPFVIGTQPFKYVTTFHGQYTGNTVSYLDSVTIGSRYTVRGFDGETLLAGSRGFYWRNELQVPVAQTGLSAYAGLDYGRVWGPEPVALVGTQLAGAVIGVKGSLMTRFGGYGYDLFAGTPVYKPSGFPTARVTVGFQLTAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IU4</accession>
    <name>Q63IU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188444.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111978.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1972"/>
    <dbReference type="EnsemblBacteria" id="CAH39450">
        <property type="protein sequence ID" value="CAH39450"/>
        <property type="gene ID" value="BPSS1972"/>
    </dbReference>
    <dbReference type="GeneID" id="56596832"/>
    <dbReference type="KEGG" id="bps:BPSS1972"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5471"/>
    <dbReference type="eggNOG" id="ENOG5032RVJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEHGELW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021686">
        <property type="entry name" value="DUF3268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11672">
        <property type="entry name" value="DUF3268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="149" mass="16522" checksum="FEE1DF2778D58466" modified="2004-10-25" version="1">MRVGRPVPALPQPVCDYCGAKALLARFGDDAYPYREDHGELWICPPCDAWIGVFPRSRRHVPLGRLANAELRHAKSELHAALEPLVAAKMRRDGCNAFEARAKGIRWLATQLGLDAASSTIHTLDLDACRNALRLVEQFMSRKSPPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW7</accession>
    <name>Q63IW7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="12" type="ordered locus">BPSS1949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187346.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111955.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1949"/>
    <dbReference type="EnsemblBacteria" id="CAH39427">
        <property type="protein sequence ID" value="CAH39427"/>
        <property type="gene ID" value="BPSS1949"/>
    </dbReference>
    <dbReference type="GeneID" id="56596858"/>
    <dbReference type="KEGG" id="bps:BPSS1949"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5439"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITPFIFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="24628" checksum="A2C59962814A9A69" modified="2004-10-25" version="1">MNASPLSTVPLFSVGPVGISAPVLATWAIMAVLVALALVARRRLSVDAPSRLQSVLELFVATVDAQIADTMQTPPARYRALIGTIFVLVFCANGASLVPGVEPPTAHLETDAALALVVLAATLYYGVRARGVRGYLATFAEPTWVMIPLNVVEQLTRTFSLIVRLFGNVMSGVFVIGIVLSLAGLFVPIPLMALDLLTGTVQAYIFMVLSMVFIGAAVSGDETSAPRRGQENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J35</accession>
    <name>Q63J35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552069.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111887.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1881"/>
    <dbReference type="EnsemblBacteria" id="CAH39359">
        <property type="protein sequence ID" value="CAH39359"/>
        <property type="gene ID" value="BPSS1881"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1881"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5347"/>
    <dbReference type="eggNOG" id="COG2733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGWTPRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="428" mass="47813" checksum="133E051C37F4AECE" modified="2004-10-25" version="1">MLDDKERELRNSKRRALALLLAAAGVFAATLFAPRGFWIDGVKAVAEASMVGALADWFAVVALFRRVPIPFVSRHTEIIPQNKDKIADNLAAFVHEKFLDPASIVALIKRHDPAARLAQWLATPRNANVLGGYAARLVAFGLDMTDDARIQSFVKDAFHAVLERIDLSQSAGAILDTLTKDGRHQALLDDGIAQIVGFLRDPDNRASIAAYIVDWLKYQFPKMEKLLPTNWLGEHGAELISNVVTRVLTQIAEDPEHRLRRSFDDAAARLVTRLKSDPAFIAKGEEIKRYLRDGDAFNRYVKDMWDQLRAWLKADLARDDSVVHRRATALGGWLGERLAQSPELRDSMNEHVERAASEMAPEFAEFLTRHISDTVKNWDAREMSRQIELNIGKDLQYIRINGTLVGGLIGLGLYAVSSAARWAGALPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JB2</accession>
    <name>Q63JB2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546784.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111810.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1806"/>
    <dbReference type="DNASU" id="3096776"/>
    <dbReference type="EnsemblBacteria" id="CAH39282">
        <property type="protein sequence ID" value="CAH39282"/>
        <property type="gene ID" value="BPSS1806"/>
    </dbReference>
    <dbReference type="GeneID" id="56529778"/>
    <dbReference type="KEGG" id="bps:BPSS1806"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5249"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THSHPNE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="3">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="140" mass="15464" checksum="1AD455AF70AE0D67" modified="2004-10-25" version="1">MTGLNERGFGAWNRIERETLTERIERQVVSGDALTMARLYLKKGAFVGTHSHPNEQLTYILEGRLLFRYGEHLEHEVEVGPGEILHLPANVPHNALCLEDAVDLDVFTPVRTDWLAPGGNRYFAGASAATSPTPVPSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI7</accession>
    <name>Q63JI7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940958.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111735.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1729"/>
    <dbReference type="EnsemblBacteria" id="CAH39204">
        <property type="protein sequence ID" value="CAH39204"/>
        <property type="gene ID" value="BPSS1729"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1729"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5150"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KTGQNRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="180"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="579"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="694" mass="75175" checksum="AC8CD4805D43202E" modified="2004-10-25" version="1">MGPASVPSTHAVAARIIDDLPARHAAGLDAATRAQVERGRYVARLGDCVACHTGDKSKPLAGGLALRTPFGELHSTNITPDPQTGIGRYTFAQFDRAMRKGVAADGRRLYPAMPYPSYAKVAAEDMRALYTYLMKGVAPVRQANRALALRFPFNQRWGLALWNWAFLDDTPFQPDATRSAEWNRGAYIVQGLGHCGACHTPRGLGFQEKAMSGAGSAGRYFLAGETVEGWRALSLRALWTPQDTAEMLKTGRNRYGAVSGNMVDVVQHSTQYMSDGDLLAVGAYLESLPAAGRDKPMQVPQPPAPAIARAGPPAADISSRVPADLYTSRGGLAYLQFCNDCHRSDGAGVRDVFPPLAGNAALLSEDPSTLVHIMLTGWRSAQTASHARVLTMPAFAQLSDREIAEILNFVRRSWGRADVRAIGAGTVGRMREQLRAGTGDGARFRTPRLADMLAESNANQLTLGARLNIETRQMLPKNVGNALNCASCHLNAGTVADGSPYVGVSAFFPGYAPRAGRVITLAERINGCFLRSMNGKPLPPDSEQMQAMVAYFDWMRRETRPGDKVEGRGVGKVSHRIVPAVDNGKRIYAAQCALCHGSNGEGVKDDAGRWVYPPLWGDESFNIGAGMARTYTAAGFVQRNMPIAFHDRFPLGQGGLTDQEAVDVAEYFTHQPRPDFAGKVKDWPKDKKPDDARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JN9</accession>
    <name>Q63JN9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528958.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111683.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1678"/>
    <dbReference type="EnsemblBacteria" id="CAH39151">
        <property type="protein sequence ID" value="CAH39151"/>
        <property type="gene ID" value="BPSS1678"/>
    </dbReference>
    <dbReference type="GeneID" id="56529912"/>
    <dbReference type="KEGG" id="bps:BPSS1678"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5083"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLWVYYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="307" mass="31852" checksum="67CBE3C404B31F85" modified="2004-10-25" version="1">MKSLIPQQPQKLVRHNVNWALDAFKRFSADRCTAMAASIAFYSAFSLAPTLVMVIAVAGWFFGADAARGEVFSHVHELIGNEAAAGVQTIVENAHRSGSRGGTAALISFAMLALGASATFASLNTALSVIWPATGARASSVLGLVRIRLISFGLVLGVAFLLIVSLVLDTAITFIGRWLWGASPYVVIGNLLQFSIGIAVLAFAFGTLMKFLPDARVSNRDAMTGGIVSAVLFSAGKKLFALYLAHAGTASAFGAAGSFAVLLMWLYFSAAVLLLGAEFAAARGAARASGEAAQPGEAAPARGGPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JS8</accession>
    <name>Q63JS8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyruvate dehydrogenase [ubiquinone]</fullName>
            <ecNumber evidence="2">1.2.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pyruvate oxidase</fullName>
            <shortName evidence="2">POX</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyruvate:ubiquinone-8 oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">poxB</name>
        <name evidence="7" type="ordered locus">BPSS1636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2</text>
            <dbReference type="Rhea" id="RHEA:27405"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="1.2.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="2">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.5.1" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940903.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111644.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1636"/>
    <dbReference type="EnsemblBacteria" id="CAH39111">
        <property type="protein sequence ID" value="CAH39111"/>
        <property type="gene ID" value="BPSS1636"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1636"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5028"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YEATHEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052737">
        <property type="term" value="F:pyruvate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042867">
        <property type="term" value="P:pyruvate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00850">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044261">
        <property type="entry name" value="PoxB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="190"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="380"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="FAD-binding domain" evidence="2">
        <location>
            <begin position="182"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="407"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="434"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="2">
        <location>
            <begin position="461"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Moves into active site upon enzyme activation, plays a role in electron transfer" evidence="2">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="572" mass="60867" checksum="538403F160370EED" modified="2004-10-25" version="1">MASTIADYLARTLAAAGVTKIWGVTGDSLNGLSDSLRRDGGIRWMHTRHEEVAAFAAGAEAAQTGRLAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAQIPSTEIGLGYFQETHPQELFRECSHYVELVTNASQFPRVLERAMRAAIGEHGVAVIVLPGDVALSAAPARTPSWFDFASPVTTPVDADLERLAALLDGSDAVTLLCGSGCAGAHDEVVALADALAAPVVHALRGKQHIEYDNPNSVGMTGLIGFSSGYHAMQSCDTLLMLGTDFPYRNFYPTRARIAQIDRRASALGRRAPLDVGLVGDVRATLSALLPRIRRKTRRGFVERALAHYAAARKGLDELARPSPAGRPIHPQYLTRVVDELAAADAIFAADVGTPTLWAARYLTMNGRRRLHGSFNHGSMANALPQALGAQAAHPGRQVVSLSGDGGLSMLLGDLLSARQLDLPIKVIVYNNSSLGFVAMEMKAGGYLDTGTDLHETDFAAIAKGAGLYSLRVTESEALPDALGKLLAHPGPALLDVVTDKHELAMPPKIEWAQAKGFSLYMLRAVLSGRGDEVLELAQTNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT7</accession>
    <name>Q63JT7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Type 3 secretion system ATPase</fullName>
            <ecNumber evidence="13">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSS1627</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="13"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528905.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111635.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1627"/>
    <dbReference type="EnsemblBacteria" id="CAH39102">
        <property type="protein sequence ID" value="CAH39102"/>
        <property type="gene ID" value="BPSS1627"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1627"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5013"/>
    <dbReference type="eggNOG" id="COG1157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICELRTP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013380">
        <property type="entry name" value="ATPase_T3SS_SCTN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02546">
        <property type="entry name" value="III_secr_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AAA" evidence="15">
        <location>
            <begin position="164"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH39102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="442" mass="47114" checksum="0B6131C3FC5F64C2" modified="2004-10-25" version="1">MNALADLSRVADAMAARLAIEPAVGMTGKVLEVIGTLVRVVGLEATLGELCELRGASGALIQHAEVVGFTRNVALLSPFGTLGEINRGTRVIGLRRPLSVKVGNGILGRVIDSFGEPIDGRGELDYDALRPVLAAPPNPMSRRMVDASLATGVRIVDGLITLGEGQRMGIFAPAGVGKSTLLGMFARGASCDVNVIALIGERGREVREFVELIMGEDGMARSVVVCATSDRSSIERAKAAYAATAIAEYFRDQGKRVLLMMDSLTRFARAGREIGLAAGEPPARRGFPPSVFAELPRLLERTGMGEHGSITALYTVLAEDDSGSDPIAEEVRGILDGHIILSREIAARNQYPAIDVLGSLSRIMPQVATREHVGAAGRLRQLLAKHREIETLLQLGEYQAGSDPAADEAVAKIDRIRAFLNQRTDEYSPPDATLAALHELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K62</accession>
    <name>Q63K62_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940775.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111510.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63K62"/>
    <dbReference type="STRING" id="272560.BPSS1503"/>
    <dbReference type="EnsemblBacteria" id="CAH38976">
        <property type="protein sequence ID" value="CAH38976"/>
        <property type="gene ID" value="BPSS1503"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1503"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4850"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHRHYAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="2">
        <location>
            <begin position="418"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108231" checksum="6739D3E9234A88B4" modified="2004-10-25" version="1">MPSSPRHDAPASRANAAPSANARRFTFASDAYDPATFDVVDINGRDAISQPYRFEITLVSRQLRIDFAKMLSRGATLAILPPFGEAGTTRYAGVLAEFEQKKRFRDFTVYRATLVPRLWRLSLYKASDVYLNEQTIPDIVKRVLRAASFGSRDFRMRHGGGYRKRSFVCQYDESHLDFVSRWMEKEGLYYYFEHDGRHETLVIVDDRRHQPGPADDLALRYLPATSLDAGIEADRVQAFTCRATPLPREVVLRDFNHRKAELSLEVRERVARDGVGERVSSDEHFHTKDEGQRYAKLRAEALVCEGRRFAGESTAAGLRAGRFFALSGHYRQDFDGRYLVTALTHRGSQAHLLFPDLDAPFGATPGEPIYRAEFEAIAADLQYRPPRTTPKPRAAGVVSAIVDGEGGGKLAELDEYGQYKVRFPFAHTAHPANKASARIRMATPYAGDDRGMHLPLLKRTEVKIAFDGGDPDRPVIVGAVPNSSHRSVVTRRNPAEHRILTEHNQLYMKDGSGAATWLHAPNNHIGIGAVGPGDGLALLTSGNKFDFSLGNAYSFSGGLKCSVSMGGNTDVYVGVRNSLDVSANFLTTLQGNLRWMLPGSRSFEINDSASTLLQTLHKQSATGAIRLSAGQDASALLQKQLDKLKGTVRKFMIVSGLANAGSAAAAAGLIKGGGKLADLPWAGFGISAAQFAGATGVSTALMATSRTLLANVAKLQEALPLVADLSLGKQGIALAAKNLTHATRMSLTVDGVSWSTHAKGPGAAGAAMSVGKGRWGVEAAKHAHVHASDTLLFAVPADPTTQFDLKDLIGLRRDLDECMKDIADLEADISENEVLSTDQNTFGVSALIPTPPSPAGALAAVAIKVKQAKLVELKAKQKLVALKVDNLQQKFAKHVQHLSAVRMSASDAQLGFKGNRLVATADGVTLAHAQGKAKLDVREAKIGVTAGKSSVELDEGKIAAGCGSASLKLGSDGAIDVSATDVKLNGTNVKLNGSASLKFDGQLIQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K79</accession>
    <name>Q63K79_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184911.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111493.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1486"/>
    <dbReference type="EnsemblBacteria" id="CAH38959">
        <property type="protein sequence ID" value="CAH38959"/>
        <property type="gene ID" value="BPSS1486"/>
    </dbReference>
    <dbReference type="GeneID" id="56597738"/>
    <dbReference type="KEGG" id="bps:BPSS1486"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4828"/>
    <dbReference type="eggNOG" id="COG3427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPNWHPA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="16225" checksum="EB14E51A4EDBD0A6" modified="2004-10-25" version="1">MNHTSFASSVIDAPIERVWAFFRDFDGLPAFHPAIVESRLEPGPDAYTVGAVRYLTLADGYVREKLLKLDEPNHALEYAIVESTMPVRDYVAGVQLVPVTDSGKTFAQWWANFTTQGVELQPVAESISEHVFAAGFRALADKLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KD7</accession>
    <name>Q63KD7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycine betaine/L-proline-binding protein ABC transporter component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533171.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111435.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1423"/>
    <dbReference type="EnsemblBacteria" id="CAH38898">
        <property type="protein sequence ID" value="CAH38898"/>
        <property type="gene ID" value="BPSS1423"/>
    </dbReference>
    <dbReference type="GeneID" id="56530157"/>
    <dbReference type="KEGG" id="bps:BPSS1423"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4748"/>
    <dbReference type="eggNOG" id="COG2113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KAGQIKV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033265">
        <property type="term" value="F:choline binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015871">
        <property type="term" value="P:choline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13640">
        <property type="entry name" value="PBP2_ChoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017783">
        <property type="entry name" value="ABC_choline_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03414">
        <property type="entry name" value="ABC_choline_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266942" evidence="2">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="316" mass="33893" checksum="ABDE7910C60A2EC9" modified="2004-10-25" version="1">MKRNLIAAACGLAIAAAPFASARAGDAPTCKAVRFADVGWTDIAATTGLASTMLAGLGYAPTKTIASVPITFAGIKSKQIDVFLGYWSPTMDPMIAPFTKAGTIKVLAAPNLTGAKYTLAVPDYVYQGGLKSFADIQKYADKLNGRIYGIEPGNDGNALIKKMIDGNQFGLGKFKLVESSEAGMLVEVNRAIRDKQWIVFLGWEPHPMNVQMKIDYLSGGDDVFGPNYGEAKVLTATPPDYAARCPNVAKFVSNLQFTTSIENHVMLPIMNKEDPNKAAAEWLKANPQSLDKWLAGVTTFDGKPGLPAVKHYLGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KJ0</accession>
    <name>Q63KJ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533329.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111382.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1371"/>
    <dbReference type="EnsemblBacteria" id="CAH38843">
        <property type="protein sequence ID" value="CAH38843"/>
        <property type="gene ID" value="BPSS1371"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1371"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4685"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QITPWET"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="41484" checksum="DEB0D9861487DA7B" modified="2004-10-25" version="1">MTADVPASPLAADSAQPRLRFGIVLLPNFTLTAFSGFVDMLRLSADDGDHSKPVRCSWTVIGDTLAPVRASCGIQLTPWQTFDAADAFDYVVVVGGLLHSGPQAGPQTLEFIRRAAAAGANLVGICTGAFALMRAGVLDGHRVCVSWFHYWDFVERFPGADPDLLIADRLFVIDRRRITCSGGRASIDVAAAILLRHFDHATVQKALRILLVGEMQKGNAPQPHPPGLEPATHPKVKRAILLMEQHVGRALPLDELACKLDLSTRQLERLFKAQTGKSPQAFAKQVRLRTAAWLLTSSDRTVADIASSCGFADASHLGREFRKQFGAPPAAYREKGGAAGDADADADAGATGDARPRPDADGGPEADFDANTRKHPDDDPAGGGRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L11</accession>
    <name>Q63L11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205562.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111210.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1200"/>
    <dbReference type="EnsemblBacteria" id="CAH38667">
        <property type="protein sequence ID" value="CAH38667"/>
        <property type="gene ID" value="BPSS1200"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1200"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4435"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQSYVET"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="493" mass="53650" checksum="B680222FF63B20AD" modified="2004-10-25" version="1">MDLQISLRDRRDLAGQIYRQLRAAIVDGRLAAGARLPSTRELARQLGVSRKTTLDAFERLASEGFLLARTGNGTFVAGGLTRVPGAREPAANGSGTRAQAPRADGRDAALARAHAGWSDVPAGLSMPPPHAPLAFDFRGGVTDKVHFPWDDWRRSIQHALRAQARSSGDYRDPAGEPELRDAIARYVGFSRAVACDWRDVIVTQGAQQALDLLARVLVRPGDIVAVEEPGYPPARAAFAALGACVIGVPVDAHGLVVAQLPDDARFVYVTPSHQFPLGMPMSLERRVALLEWAQRRRAVIVEDDYDCEFRFEGRPLEPLKSLDRAGLVAYVGTFSKTLFPELRIGYAVPPRSLNLALRKAKQIVDWHACTLTQTALARFIADGAFARHLRRIHRRYDARRRLLAAHLHGALSHWLRPVIPAAGIHLTARFATGIDERAALDAARDADIDLHGISAFYADSPAESGVLFGYGGIDAPAIDVALTRLAGVLKRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L23</accession>
    <name>Q63L23_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS1185a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111198.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38654">
        <property type="protein sequence ID" value="CAH38654"/>
        <property type="gene ID" value="BPSS1185a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1185a"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5351"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="41" mass="4489" checksum="333BEBF2654CC3DD" modified="2004-10-25" version="1">MSKTPLDRQDWIAGLEKGLAIIEAFDISKAWVAAIDNGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L64</accession>
    <name>Q63L64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrogenase/NADPH dehydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004548282.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111157.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1144"/>
    <dbReference type="EnsemblBacteria" id="CAH38612">
        <property type="protein sequence ID" value="CAH38612"/>
        <property type="gene ID" value="BPSS1144"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1144"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4368"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEAAWKY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="128"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="486" mass="51788" checksum="32DDB0A1B526A55F" modified="2004-10-25" version="1">MIDGYVLPALLGLPLAAGGCLALVRRQHVARVLNVGFSFLTCAAALALAARTVAHGPMYAVGALFFVDPFNVFLVALTAFVGWTTSLFSNPYMRIEHDRGKMSDGRMRLYHCMYQLFIFAMLLALLTNNVGVLWVAMEAATLATVLLVSVYRTAASLEAAWKYFILCGVGIAQALFGTILLYLAAGRRLADGDALLWTSLNAVKTQLDPTIVSIAFVFLLVGYGTKVGLVPMHSWLPDAHAEGPTPISAVLSGLLLNVALYAVLRCKVLADGALGNGLPGHLLVGFGLVSVLVASFSLFRQKDVKRLFSYSSIEHMGLMTFAFGLGGPIATFAGLLHMTVHSLVKSAIFFAVGHAAQKARTQAIDGIRGLLQVSPTVGWGMMLGTLAILGMPPFGVFASEFLILTTAIAKLPWSAPFLLVALAAAFAAIFMRVQPMVFGESSVASLEHPPALLPVFVHLALGLMLGLYVPPYLAAWYRQAAAMIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LM9</accession>
    <name>Q63LM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198657.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110992.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0984"/>
    <dbReference type="EnsemblBacteria" id="CAH38446">
        <property type="protein sequence ID" value="CAH38446"/>
        <property type="gene ID" value="BPSS0984"/>
    </dbReference>
    <dbReference type="GeneID" id="56597350"/>
    <dbReference type="KEGG" id="bps:BPSS0984"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7304"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NYMVQDL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="433" mass="47143" checksum="C1C51BB02B2C4211" modified="2004-10-25" version="1">MSNLIVHGGAPLRGEITPSANKNAVLPILCATLLTDRPLRLVGVPDITDVRKILDIFRTLGSDVSIDYASGVLDLHHRATAFDPAVHRLPEEMRSSIMLVPPLLARFGVARLENDVKGCTLGVREIDPHVEVFERFGARIERTSDSLIVRADGPLTPNHHWLDYASVTTTENFVLCAASANGTSTLVNAASEPHVQEFCRFLAMLGVPIEGIGTSHLSVQGGRALAGGEYRFNEDFHEIATFLALGAITGGDIAVRNGSPEQFPLIDRTFAKFGVQVTHENGWSHALRDGPLKVKQPFTRNILTKVEAAPWPYLPVDLLPIFIALGVQAQGSVMFWNKVYDGAMGWTGELSKFGAHVFLSDPHRLITFGGLPLSPARVESPYIIRVAIALLMVAASIDGRSEILNAQPIRRAHPHFVENLRSVGANVEWTSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA5</accession>
    <name>Q63MA5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532760.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110766.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0755"/>
    <dbReference type="EnsemblBacteria" id="CAH38215">
        <property type="protein sequence ID" value="CAH38215"/>
        <property type="gene ID" value="BPSS0755"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0755"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6993"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CLEPRIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="336" mass="36497" checksum="1D9299F1465E8782" modified="2004-10-25" version="1">MDTLQNMRVFARVVEAGSFTAAAQSLNSTTGAMSRAVSELEARLRTRLMNRSTRRLALTPAGERYLLRCRQILADVDQAEEEASCAHERPAGVLRMHSFASIGQHYVLPALTAYRSQHPDVSIELTLSQRMPDLFDGSSDMAVVTASSLPDSELVSHLLGSTFSILCATPAYLRAHGAPRTPRDLARHACLTLRTPAFPTNEWLLEGPNGAEEIKVDGPVQTNTAESLAVAIRAGIGIGMLPLYAAIEDLRCGNLVRVLPAHRLQKMNVYALYPSRRFIDAKVRTWVEALRFHMPKMIASDEAMLSAIVAEASDATQSAIAGALDVGLESAHALSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MG1</accession>
    <name>Q63MG1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-carboxymethyl-2-hydroxymuconate delta-isomerase</fullName>
            <ecNumber evidence="1">5.3.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hpcD</name>
        <name evidence="1" type="ordered locus">BPSS0696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.3.10" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194671.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110710.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63MG1"/>
    <dbReference type="STRING" id="272560.BPSS0696"/>
    <dbReference type="EnsemblBacteria" id="CAH38156">
        <property type="protein sequence ID" value="CAH38156"/>
        <property type="gene ID" value="BPSS0696"/>
    </dbReference>
    <dbReference type="GeneID" id="56597620"/>
    <dbReference type="KEGG" id="bps:BPSS0696"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6910"/>
    <dbReference type="eggNOG" id="COG3232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHFYAEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008704">
        <property type="term" value="F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00580">
        <property type="entry name" value="CHMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004220">
        <property type="entry name" value="5-COMe_2-OHmuconate_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37950">
        <property type="entry name" value="PTHR37950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02962">
        <property type="entry name" value="CHMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="14298" checksum="22DDEDF218F9B71B" modified="2004-10-25" version="1">MPHIIVEYTANIRDDARIPVLLKSINETLIAQGGVFPTGGIRSRAIELQDYCVADGTADDAFVHVTLKIGAGRDDATKKAACDALFDAIKAHFEALYARRYLALSMELAEFSETGSYKHNNIHARYKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MH7</accession>
    <name>Q63MH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110694.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0681"/>
    <dbReference type="EnsemblBacteria" id="CAH38140">
        <property type="protein sequence ID" value="CAH38140"/>
        <property type="gene ID" value="BPSS0681"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0681"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4729"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGKKVMH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="327" mass="35984" checksum="4CD0224013C7F7FC" modified="2004-10-25" version="1">MPMDQRHTRLESAAHAPPRPDAQTLAPREAARRELAALIERFAPADGAHPSAIPALSFFRCSSPVDLGCSVTRAAFVFAAQGAKRVTVAGQAYEYDHQQCLVTSVDLPMLSQVTRASAGAPYLCVKVALDVQRIAELSAEMRMPPPEAVPTGEGIVVGALSEPLFDAALRLVRLLDTPADIPILAPLIEKELLYRLLTSGLGARLRHIAVAGSQTYRIARAIEWLRHHYTEPLRVETLAQQVNMSVSSLHHHFKHVTTLSPLQYQKQLRLHEARRLLLGQHGDVGSVALRVGYDSPSQFSREYSRLFGAPPLRDVVQRRRNGTGVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ML5</accession>
    <name>Q63ML5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110656.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0635"/>
    <dbReference type="EnsemblBacteria" id="CAH38093">
        <property type="protein sequence ID" value="CAH38093"/>
        <property type="gene ID" value="BPSS0635"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0635"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4673"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EIPHTPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="1">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="2">
        <location>
            <begin position="362"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="709" mass="77262" checksum="65235E6B9519D546" modified="2004-10-25" version="1">MRGSQFVLKAGDAFVVSDALGDIAGRDDGLFVDDMRVLSQWRLTFGGRAPSLLSGATSADNASFTAHLTNRPLPPLGGRETPEGVIHIERMRVLADNVLHEALTLTNYGTCDAEVPLSVSFGADFKDMFEVRGSRRERRGAVAPPCVEAGAVRLRYDGLDAVERSVRIGFEPKPDTLAVDRADYTLTIAAQACVSLYLTVEARVGAAHAGGDAFARRPCVATGRGALRKALADVHRAMRERRRTIARVHTSNPLFNAWLDRSLADLGLLTTSLETGPYPYAGIPWFSTPFGRDAVITSLQMLWLQPSLARGVLRFLAEHQARETSAFRDAEPGKIMHEFRKSEMAATGEVPFALYYGGVDTTPLFVVLAGAYLEHTGDESLIDELWPALERAAQWVSTVCERNPRGLLDYQRTSARGLANQGWKDSQDSVFHADGRFPSGPIALVEVQAYACAAFDAMATFSRRRGHAADTVRYAQRAKRLREQVEALFWMPEAGFYGIAVDGHGELCRVLASNAAHLLAFGLPEQSRGESVARVLGSTLFRTGWGVRTLAAGQPRFNPMAYHNGSIWPHDNALAARGLARYGDKRAVLDLLRALFEAAVSFDMRLPELFCGFPRRRGEPPTAYPVACLPQAWAAGAPFMMLQACLGISVDAARGEVRVERPELPEGVDWLRVDDLRVGGDSVSLTFRRVEGQVVAAAEPGGARVVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR8</accession>
    <name>Q63MR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subfamily M23A unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110601.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0580"/>
    <dbReference type="EnsemblBacteria" id="CAH38037">
        <property type="protein sequence ID" value="CAH38037"/>
        <property type="gene ID" value="BPSS0580"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0580"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4603"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CERNGSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000841">
        <property type="entry name" value="Pept_M23A_Blytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00933">
        <property type="entry name" value="BLYTICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267376" evidence="2">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="329"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="411" mass="42991" checksum="1BFF4EDE4636F0C4" modified="2004-10-25" version="1">MVWRGASDSITRWLAAPLIAAGLTGAASAAPVDMPDLQHAVRQAFSARLGKQAPAAPAVRDDLIESVRSDPEAGWVLGTVTQVVPNDTPAYPVTKLFIARRASEGWAVGIEGTDAFYALAAASPAKLLAGDERAHLNAGRAPTAPPRKAAPAQTGLALPWQQGTAWYWTGGAHGWSGDSRPFNSLDFSGGNGQVLAARDGTLYKSCERNGSAIVKVVHDNGYTSTYYHMVQLTQAGSGTRVRQGQYLGRVGNGLPCGGQTTGPHVHFALSQGGSDVPVNGKTIGGWQFFEGSNAYSGYAVRNQRRVSVQASLTNYGADDSGGPTEPSRPVKATVQSPGPVNLRSAPSLSASIVGTVANGAAVQLACYAYGDTVQGNWGATRLWYRLDSNRWVSDGFVYTGSNDPVVSACAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR9</accession>
    <name>Q63MR9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity branched-chain amino acid transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">braG</name>
        <name evidence="9" type="ordered locus">BPSS0579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523163.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110600.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0579"/>
    <dbReference type="EnsemblBacteria" id="CAH38036">
        <property type="protein sequence ID" value="CAH38036"/>
        <property type="gene ID" value="BPSS0579"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0579"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6752"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IMMQKIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="25388" checksum="0407E9FD374FFA5B" modified="2004-10-25" version="1">MLKLEKIHTHYGAIEALSGVSIEVKKGEIVTLIGSNGAGKTTLMMTVCGTPRASSGRVLFEGEDITAMPTHEIMRQGLAISPEGRRVFPSLTVLENLKMGGFFANRHEIDEGVEHVYRLFPRLKERSAQRAGTMSGGEQQMLAIGRALMSRPRLLLLDEPTLGLAPLVIAQIFDIIRTIRAEGVTVFLVEQNAHKALQVADRGYVLETGRVVLADTGANLLENDRIRAAYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY1</accession>
    <name>Q63MY1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110538.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0517"/>
    <dbReference type="EnsemblBacteria" id="CAH37974">
        <property type="protein sequence ID" value="CAH37974"/>
        <property type="gene ID" value="BPSS0517"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0517"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4530"/>
    <dbReference type="eggNOG" id="COG3517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPANHES"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010269">
        <property type="entry name" value="T6SS_TssC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044032">
        <property type="entry name" value="TssC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044031">
        <property type="entry name" value="TssC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35565">
        <property type="entry name" value="PTHR35565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05943">
        <property type="entry name" value="VipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18945">
        <property type="entry name" value="VipB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03355">
        <property type="entry name" value="VI_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VipB" evidence="1">
        <location>
            <begin position="71"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="VipB_2" evidence="2">
        <location>
            <begin position="383"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="503" mass="57188" checksum="91E4C568987B1689" modified="2004-10-25" version="1">MSMQQLESSAEKVVVDQNNVNEDLKDILRRSFRPRTNEAAEAVQNAVETLLTYARRSRVVVREDVAQTIEQLVAELDKKISEQLTLVLHNKRFQSLEGAWRGLHYLVSNTDTSENLKIRYLNISKADLGKTLRRFKGVVWDQSPIFKMIYEQEYGQFGGEPFGCLIGDFYFDHSMQDVSILTEMSKISAAAHAPFIAAAAPGLLQMDDWSELSNPRDVSKIFTATEYAFWRRLRESNDSRYLALTLPRFLARVPYGPKTQPVEEFGFEEKVDPNRAEDFCWANSAYAMGANITRAFKTYGWCTKIRGVESGGAVEVLPKFVLPSQDREVDLHCPTEIAISDRREHELSESGLMPLVYRKNSDTAAFIGAKTVHRPAIYEDDDATANSNLSSRLPYIFATCRFAHYLKCIVRDKIGSFKSAEDTQRWLNDWLMNYVDGDPSISSEVTKSQRPLSAAEVVVDEIPENPGYYRAQFFLRPHFQLEGLTVSLRLVSKLPSTKHEVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N54</accession>
    <name>Q63N54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110465.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0442"/>
    <dbReference type="EnsemblBacteria" id="CAH37898">
        <property type="protein sequence ID" value="CAH37898"/>
        <property type="gene ID" value="BPSS0442"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0442"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4438"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YVQTPVG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="411" mass="43956" checksum="66ACB0578DEB6261" modified="2004-10-25" version="1">MHARDAIVRACPRDPGFNERLLEAYALGIAHRPQTMFRTLGADVLDRRAPNDRRLNLADSCPAPAGFTGRTERGTERRARAARVGPACRTLFTLIGSSMQTRRLAVRSALWGAALMFGLAQAPAAFADAAAEAAAPARAAASAPAVSVGPQYDTTHVYVAASDLDAFVDSFVATFGGKASPRVTLTVTPTPSETLSQYVQTPVGMLSVFGFKTPVPYPFGAERTGYLVTDLDAAVKAARAAGADLVVDSFDDPIGRDAVVRWPGGVMMQLYWHRKAPSYAPLATVPDNRVYLSPYEADRFVTSWMRFSHGKVVADDRRGDGGAIGRPGTDVRRIVIESGFGRVVAFVTDGKLPYPYGRETTGYAVADLDAVLDKAKAAGVEVLAQPYRTRAGRTAMLAFPGGYLAEVHDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NA1</accession>
    <name>Q63NA1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriophage protein Gp49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552388.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110418.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0396"/>
    <dbReference type="EnsemblBacteria" id="CAH37848">
        <property type="protein sequence ID" value="CAH37848"/>
        <property type="gene ID" value="BPSS0396"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0396"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4389"/>
    <dbReference type="OMA" id="SRETWAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="91" mass="10328" checksum="5588FC6FD1A6BF2B" modified="2004-10-25" version="1">MRGSEDRDRVPSKGNPVESKRKLPTVSVEWLENAAADLEVSANASRETWAVLGLSHRYSENIGRAHAMRHAARLKLEYDRRLFLRSIGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NE2</accession>
    <name>Q63NE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0423 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266710.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110377.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0357"/>
    <dbReference type="EnsemblBacteria" id="CAH37805">
        <property type="protein sequence ID" value="CAH37805"/>
        <property type="gene ID" value="BPSS0357"/>
    </dbReference>
    <dbReference type="GeneID" id="56597207"/>
    <dbReference type="KEGG" id="bps:BPSS0357"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6480"/>
    <dbReference type="eggNOG" id="COG3470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRFWTEP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018470">
        <property type="entry name" value="Metal-bd_Tp34-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038482">
        <property type="entry name" value="Tp34-type_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10634">
        <property type="entry name" value="Iron_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017018">
        <property type="entry name" value="Tp34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266189" evidence="3">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="19701" checksum="1BD08C6ED57000C7" modified="2004-10-25" version="1">MLRSSFVRSGVALAAACAALSATAAEYPIGKHQIQGGMEIGAVYLQPITMDPEGMMRKASDSDIHLEADIHAVKNNPTGFAEGDWMPYLQVTYKLTKQGDAKWAAQGDLMGMVASDGPHYGDNVKLNGPGKYHLTLVVKPPMQTGHMAFGRHVDKETGVGAWFKPITLEYDFPFAGIGKKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ0</accession>
    <name>Q63NZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205354.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110179.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0158"/>
    <dbReference type="EnsemblBacteria" id="CAH37603">
        <property type="protein sequence ID" value="CAH37603"/>
        <property type="gene ID" value="BPSS0158"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0158"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6216"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHDEFQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266205" evidence="1">
        <location>
            <begin position="25"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="638" mass="67784" checksum="1B0C57D323B64941" modified="2004-10-25" version="1">MVRKRIRAVFAAALVGLAAHAAHAQYTTDWIANTYGTIASHVGNNARSMWVSPEGVIYTASFWDENAGGVAIYQNGKTLGSIGTHAEFQGGAITGNATSIFAAMQYSTPQGSGTVGRYNRATLQRDLTIPVSVWNAVSRADVITGLATAGTLLYASDYFGNRVRVFTTEGVWQRDIGIANPGALALDDAGNLWVAQKNAAKIVEFSPTGALMNTIQMASASRPASLYFDASKRQLMIGDQGPDMNVKLYAIAGMPKQVGTFGVQGGYLDTTTGIRGQVGDRRFTRVVGIGKDAAGTLYVLNNPWGGGWDLGRNGATDIHAYDALGNALWKLQALNFEAIAAPDPTTDGALFYSGMNVYSGTAGGTFVANTVDPFTYPSDPRLDMNDYQRGQHFGQLVSVGGHKILVASGQNPGNFNFYHFNAASGYIAIPDASLPGKGFNTSLQVTAGFSIDNKGDVWAGLNGTNAISHYPLAGIDASGKPSWGAPTSIPTPASVQPTTRILYLSDSDTMILAQGIAGSWDWTAMNGRIEVYHGWSAGNVTQPNPVIALTSPNPKSIASAGNYLFVGYVHTVPNIDVFDLNTGQLVATLTNSNTGMMDVGNDVDSMYGLRAYLRSTGEYVITKDNYNGSSIVVYRWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PB6</accession>
    <name>Q63PB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556447.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110053.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0029"/>
    <dbReference type="EnsemblBacteria" id="CAH37472">
        <property type="protein sequence ID" value="CAH37472"/>
        <property type="gene ID" value="BPSS0029"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0029"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6028"/>
    <dbReference type="eggNOG" id="COG1279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FARPRAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="22007" checksum="F1F55ED3E8A4700C" modified="2004-10-25" version="1">MNWIAFSHGAMLCASLIVTIGAQNAFILRQGIMRSHVGKIVLLCTLSDMLLIGAGVGGASVLVERYPAFVHAVLYVGLAYLAWFGLSALRRAFKPGHETLDATGAVAAPPAQRAWPIVLMTLAFTWLNPHVYLDTFLLIGTAGAREPEGARSAFAIGAMAVSAVWFVALGYGARLLAPWFKRALAWRVLDGAIGGMVLFLAAVQLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PH9</accession>
    <name>ATPG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpG</name>
        <name type="ordered locus">BPSL3397</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195831.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109990.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PH9"/>
    <dbReference type="SMR" id="Q63PH9"/>
    <dbReference type="STRING" id="272560.BPSL3397"/>
    <dbReference type="EnsemblBacteria" id="CAH37409">
        <property type="protein sequence ID" value="CAH37409"/>
        <property type="gene ID" value="BPSL3397"/>
    </dbReference>
    <dbReference type="GeneID" id="56593897"/>
    <dbReference type="KEGG" id="bps:BPSL3397"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1793"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000073259" description="ATP synthase gamma chain">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <sequence length="291" mass="31858" checksum="E4E32C0799BBA383" modified="2004-10-25" version="1">MAGMKEIRGKIKSVQNTRKITKAMEMVAASKMRRAQERMRAARPYAEKVRAIAAHMSRANPEYRHPFMVANDGVKTAGMILVTTDKGLCGGLNTNVLRASLQKFKELEEQGQKVEATAIGGKGLGFLNRFGAKVISQVVHLGDTPHLDKLIGAVKTQLDLYSEGKLSAVYLAYTRFVNTMKQETVIEQLLPLSSEHFDANDGTPATSWDYIYEPDAQAVVDELLVRYVEALVYQAVAENMASEQSARMVAMKAASDNAKTVISELQLSYNKSRQAAITKELSEIVGGAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PJ3</accession>
    <name>Q63PJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109976.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3384"/>
    <dbReference type="EnsemblBacteria" id="CAH37395">
        <property type="protein sequence ID" value="CAH37395"/>
        <property type="gene ID" value="BPSL3384"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3384"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3848"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARFRHFS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="43116" checksum="E857A93DB70B5E00" modified="2004-10-25" version="1">MAARPFTSPGGSMQSAAAPRSKLPDVGTTIFTVIGQLAAEHEALNLSQGAPNFAPDPALVERVARAMRDGHNQYAPMAGIAALREALGVKTERLYGERYDPDSEVTIVASASEGLYAAISALVHPGDEVIYFEPSFDSYAPIVRLQGATPVAIRLSPERFRVNWDEVAAKITPRTRMLIVNTPHNPSATILGEADVARLAQLVAGTDIVVLSDEVYEHVVFDGARHHSMARDRALAERSVIVSSFGKSYHVTGWRVGYCLAPAELTRELRKVHQFMTFAADTPMQHAFAAALAEPASYLELGAFYERKRDLLVRELAGSRFELLPSEGSFFMLARFGHFSDESDADFVLRAIRDARVATIPLSAFYADGANTGCIRLSFSKDDATLVEGARRLCSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q36</accession>
    <name>RS4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">BPSL3188</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197926.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109782.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q36"/>
    <dbReference type="SMR" id="Q63Q36"/>
    <dbReference type="STRING" id="272560.BPSL3188"/>
    <dbReference type="EnsemblBacteria" id="CAH37199">
        <property type="protein sequence ID" value="CAH37199"/>
        <property type="gene ID" value="BPSL3188"/>
    </dbReference>
    <dbReference type="GeneID" id="56594568"/>
    <dbReference type="KEGG" id="bps:BPSL3188"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2050"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132357" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="207" mass="23151" checksum="71995EEF480E3B36" modified="2004-10-25" version="1">MARYIGPKAKLSRREGTDLFLKSARRSLADKCKLDSKPGQHGRISGARTSDYGTQLREKQKVKRIYGVLERQFRRYFAEADRRKGNTGETLLQLLESRLDNVVYRMGFGSTRAEARQLVSHKAITVNGIVANIPSQQVKAGDVVAIREKAKKQARIVEALSLAEQGGMPSWVAVDAKKFEGTFKQVPERADIAGDINESLIVELYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q54</accession>
    <name>Q63Q54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109764.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3171"/>
    <dbReference type="EnsemblBacteria" id="CAH37181">
        <property type="protein sequence ID" value="CAH37181"/>
        <property type="gene ID" value="BPSL3171"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3171"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3623"/>
    <dbReference type="eggNOG" id="COG3167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVFFDPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="319" mass="32922" checksum="84D215C017D9D850" modified="2004-10-25" version="1">MSGAVERAAGRRAWARWADSRRMSGAGWRMAMRAAFACGVFVCGVYAGRDADWGGVERGRAVLESVAAREARARRLLAAASGRSAPSAGAERSPAQPQTPSDWAMRLAGHAGASGLRVRKLERLGGERAGERGDVGADERATRATKTTNKAAHGSGNQAANEAADYVFAISAEGDFDALYRFLSGLAALPALVVPVTSNVKRDDGATLLEARLDVWPALPGAEADGPPPADARAVPVADPFSAMPMQAIDDAAGVARLVGVIRDRLSGLALFERGSDAWSVAPGQTVDGARVARIRAAGVTLATHGGGRRVMTVGGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q83</accession>
    <name>Q63Q83_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BolA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199917.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109735.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3142"/>
    <dbReference type="EnsemblBacteria" id="CAH37152">
        <property type="protein sequence ID" value="CAH37152"/>
        <property type="gene ID" value="BPSL3142"/>
    </dbReference>
    <dbReference type="GeneID" id="56594086"/>
    <dbReference type="GeneID" id="66545691"/>
    <dbReference type="KEGG" id="bps:BPSL3142"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2101"/>
    <dbReference type="eggNOG" id="COG5007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HQLVYGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="79" mass="8850" checksum="4F93EF90BB7581F9" modified="2004-10-25" version="1">MLPTPELVKQYIEAGLACTHLEVEGDGQHFFATIVSSAFEGKRPIQRHQLVYAALGDRMKQEIHALSMKTLTPAEWQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QE0</accession>
    <name>Q63QE0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549931.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109678.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3083"/>
    <dbReference type="EnsemblBacteria" id="CAH37094">
        <property type="protein sequence ID" value="CAH37094"/>
        <property type="gene ID" value="BPSL3083"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3083"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2168"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFPAKEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="214" mass="22788" checksum="07F7576AA7D48230" modified="2004-10-25" version="1">MANTVAKTAAKAAAKSAGRRARGTQVAGAQAQQHLLRAAEELFYQEGVRAVGVDAVVERAGVNKMSLYRQFASKDELVLAYLERMDACFFERFDASVAKHPGKPKAQLVQYFDDLAQRASQPGYRGCPFVNVAAEFPDLDHPARRAVTANKDRLMARLVALTEAAGAREPQALAGALALLIEGIYAASQTYRPGASPIGSAPGVARQLIDAACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QJ2</accession>
    <name>Q63QJ2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="2">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">murE</name>
        <name evidence="6" type="ordered locus">BPSL3030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549955.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109626.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3030"/>
    <dbReference type="EnsemblBacteria" id="CAH37042">
        <property type="protein sequence ID" value="CAH37042"/>
        <property type="gene ID" value="BPSL3030"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3030"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2236"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="5">
        <location>
            <begin position="116"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="4">
        <location>
            <begin position="344"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="2">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="2">
        <location>
            <begin position="425"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="2">
        <location>
            <begin position="425"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="118"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="514" mass="54019" checksum="C0F6A89E890315D1" modified="2004-10-25" version="1">MSAARSSHPAHQQIAAALAWLRAHVVPGAQLHADTRSLRAGDVFVAYAVDGADNRPFIADALARGAAAVLYQPEGFPAEGLDSATSLAVPALDALAGDIASGWYGDPSDAMFSVGVTGTNGKTSCTQWIAAALTALREPCAVIGTLGSGMPGQLVHTGFTTPDAPQLQRSLAQLRDAGARAVAMEVSSHALHQGRVNGTAFDVAVFTNLTQDHLDYHRTFEAYEAAKAKLFAWRGLRCAVVNRDDPAGRRLLANLAGRVRTIAYGIDSPTQAADADRELVATNVRATATGTAFRVTSAWGEADVEVGTLGAFNVSNLLAVLGTLLAADVPFDAALAEIGKLESVNGRMQRLGGRLQNDEPLVVVDYAHTPDALEKTLDALRPIAQARGGELICMFGCGGDRDATKRPLMGAIAERLADKVVVTSDNPRSEDPQKIIDQIVAGMRDASGARRVEDRASAILQAVRGAAREDVVLLAGKGHEATQEIMGKKRAFSDQDHARLALAARTTQTRGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QP5</accession>
    <name>Q63QP5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase</fullName>
            <ecNumber evidence="6">6.3.2.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Murein peptide ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">mpl</name>
        <name evidence="10" type="ordered locus">BPSL2979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:29563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61401"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. Mpl subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.45" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109573.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2979"/>
    <dbReference type="EnsemblBacteria" id="CAH36989">
        <property type="protein sequence ID" value="CAH36989"/>
        <property type="gene ID" value="BPSL2979"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2979"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3405"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SGIAWDH"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106418">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02020">
        <property type="entry name" value="Mpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005757">
        <property type="entry name" value="Mpl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01081">
        <property type="entry name" value="mpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="9">
        <location>
            <begin position="132"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="8">
        <location>
            <begin position="338"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="494" mass="52804" checksum="09FF27D2C1936F6F" modified="2004-10-25" version="1">MFSGNRRDVRPAADFDYAHAARSSMHIHILGICGTFMGGLAVLARAAGHTVTGCDAGVYPPMSTQLEAQGIQLIEGYGAEQIDLKPDLFVIGNVVSRGNPLMEAILDRGLPYVSGPQWLGEHVLAGKWVLAVAGTHGKTTTSSMLAWVLEDAGLNPGFLIGGVPLNFGVSARLTDSSFFVIEADEYDTAFFDKRSKFVHYRPRTAILNNLEFDHADIFPDLAAIETQFHHLVRTVPGVGRLVTNGRDDALERVLSRGCWSDVERFGVDGGWQALPVENGVPVDGRFAVYWRSERVGAVDWQVQGEHNRMNALAAIAAARHVGVPPAQAAAALAAFRNVKRRMEVRGSVDGVTVYDDFAHHPTAIETTIAGLRTRIGRENTRILAVLEPRSNTMKLGVMKAQLPASLADADLVFGYGAPSGRDALGWSLPDALAPLGGKARAFDDLHALVKAVTASARPGDHVLVMSNGGFGGVHQKLLDALSARGDAAPARSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R32</accession>
    <name>Q63R32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-binding oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522137.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109436.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2842"/>
    <dbReference type="EnsemblBacteria" id="CAH36852">
        <property type="protein sequence ID" value="CAH36852"/>
        <property type="gene ID" value="BPSL2842"/>
    </dbReference>
    <dbReference type="GeneID" id="56528356"/>
    <dbReference type="KEGG" id="bps:BPSL2842"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2459"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLLMEFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="46"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="50113" checksum="5698B6CE074B08BB" modified="2004-10-25" version="1">MNHPAPPPRRPLPAAFVDALAARFGARMSVAQAVRAHHGRDESPFDPQLPDAVVFARSADDVRDAVLLCARYDVPLIPYGVGSSLEGHLLAVRGGVSLDLSEMNRVLSIDADDLTATVEPGLTRRALNDALRDTGLFFPIDPGADASIGGMTATRASGTNAVRYGTMRENVLGLAAVLADGRVVKTGTRARKSSAGYDLTRLFVGSEGTLGVITEITLRLHPLPEAVSAAVCAFGSMSAAARTVIETIQIGVPIARVEFVDALAVRAINRNTQLGLAEAPTLFFEFHGTESGVREQAQQVEALAEQNGGRGFEWATRPEDRTRLWSARHHAYFSMLQLKPGCRAVTTDVCVPISQLAACVEETEADLNASSLPCPIVGHVGDGNFHVAILVDPTKPEELAEAEALNDRIVERALRMGGTCTGEHGVGLHKMRFLAAEHGENAVDTMRAIKRALDPRNLMNPGKIFTIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC8</accession>
    <name>Q63RC8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185639.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109340.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2744"/>
    <dbReference type="EnsemblBacteria" id="CAH36752">
        <property type="protein sequence ID" value="CAH36752"/>
        <property type="gene ID" value="BPSL2744"/>
    </dbReference>
    <dbReference type="GeneID" id="56594931"/>
    <dbReference type="KEGG" id="bps:BPSL2744"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2575"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VALDRMS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="29555" checksum="DA73D9807EA07C58" modified="2004-10-25" version="1">MVPPTIPELVARAGKLPFLCDHLALADGAQGAYARLRDLRLESVYEPIYDVSMPGAPQSTSLSDAIERYGDELGFQAVTHAGGAPFDPIGAVADDQELVALDRLARSLHAINFFGAQRHGLLFLRVHERLLKSVKYDHGKHFSTVLKGFGLPPERIVIELPAAAVAHKTFLGYLTKSYQHYGFKVADKLPDPGRILAVESDMARPDYIKMDAAIALREGMVKALVGYAQRVRIPLIFDHVVDETQFELLRQYDVRLVQGPVFSQPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RT1</accession>
    <name>Q63RT1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522316.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109186.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2590"/>
    <dbReference type="EnsemblBacteria" id="CAH36598">
        <property type="protein sequence ID" value="CAH36598"/>
        <property type="gene ID" value="BPSL2590"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2590"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2768"/>
    <dbReference type="eggNOG" id="COG0477">
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    </dbReference>
    <dbReference type="OMA" id="SWVGGYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="437" mass="45895" checksum="9107117AFEE33863" modified="2004-10-25" version="1">MSDTRLSASAAAPRAANTTNHRRIVFASFIGTAIEFYDFYVYATAAALVIGPVFFPHGSATAQALSAFVTFGIAFIARPIGSFLFGHFGDRIGRKSTLVASLLVMGVSTTAIGFVPGYDAIGALAPVLLCVLRFGQGIGLGGEWGGAALLATEHAPAGKRGWFGMFPQLGPSIGFLASNGLFFALALTLSDEQFRSWGWRIPFLVSAALVAVGLYVRLKIAETPAFQAALDRHERVRVPLAALVAHHWRPTLLGALAMVVCYTLFYISTVFSLSYGVSTLHFSRQSFLGLLCFAVLFMALATPLAAAAADRFGRKPVLIAGAIAALLSGFTMAPLLGSGSMPLVALFLTIELFLMGVTFAPMGALLPELFPTNVRYTGAGVAYNLGGILGASIAPYIAQLLAARGGLAWVGAYVSAAAAISLVGVLLMRETRDAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RT9</accession>
    <name>Q63RT9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109178.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2581"/>
    <dbReference type="EnsemblBacteria" id="CAH36589">
        <property type="protein sequence ID" value="CAH36589"/>
        <property type="gene ID" value="BPSL2581"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2581"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="116" mass="12906" checksum="6F9EB44FDBF0DD6B" modified="2004-10-25" version="1">MSDGPTKKSGAPLERCAPIPYYSSPRRGAVQPHQQLEEIGMRAVIVTTTRRVRALEVRTGEHNGRRQIFLQAFWQGDDDLMHPSGPRMWLPAESADEIIAALIQANNELKAEGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW3</accession>
    <name>Q63RW3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA</name>
        <name evidence="4" type="ordered locus">BPSL2557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522324.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109154.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2557"/>
    <dbReference type="EnsemblBacteria" id="CAH36565">
        <property type="protein sequence ID" value="CAH36565"/>
        <property type="gene ID" value="BPSL2557"/>
    </dbReference>
    <dbReference type="GeneID" id="56528626"/>
    <dbReference type="GeneID" id="66547966"/>
    <dbReference type="KEGG" id="bps:BPSL2557"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2808"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FICKDQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="7454" checksum="5AEF26B968EC4A27" modified="2004-10-25" version="1">MDTGIVKWFNDAKGFGFITSDNGGEDLFAHFSEIRMEGFKTLKENQRVSFEVKTGPKGKQAANIQAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RX6</accession>
    <name>METE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metE</name>
        <name type="ordered locus">BPSL2545</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938401.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109141.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RX6"/>
    <dbReference type="SMR" id="Q63RX6"/>
    <dbReference type="STRING" id="272560.BPSL2545"/>
    <dbReference type="EnsemblBacteria" id="CAH36552">
        <property type="protein sequence ID" value="CAH36552"/>
        <property type="gene ID" value="BPSL2545"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2545"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2827"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDILPWI"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000071607" description="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="435"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="435"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="519"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <sequence length="764" mass="84451" checksum="203C1A3E04661D2D" modified="2004-10-25" version="1">MTTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAEHWRIERDAGLDCVTVGDFAWYDHVLTTLAHVGGLPRRFGFDARALTLADYFAAARGNAAQPAMEMTKWFDTNYHYLVPEYSPATTFGPGVEWLFDEVREARALGYRAKAALVGPLTLLWLGKARDGLVERLALLPRLVPAYRALLARLREAGVDWVQIEEPIFSLDLPDAWRDAARPTYEALAPGAPKLLVATYFDDASEHAALLKALPVAGLHIDLVRADAQLDAFVADYPADKVLSCGIVDGRNVWRNDLDRSLARLAPVRDALGERLWVATSCSLLHVPVDLAHEPRLDEELKTWLAFAAQKTREVAALRDALVKGRAAVAAEFDDAAAAAAARRTSARIHNPLVKRRVAALTDADARRASAYSVRAAAQRARFGLPLLPTTTIGSFPQTPEIRRARAAFKQGVLDHLGYLEAMREQVRIAIDKQLAYGLDVLVHGEAERNDMVEYFGELLWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGWASYAQSLSAKPVKGMLTGPVTMLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMIQIDEPALREGLPLKARERAAYLDWAVRAFGIAASGVADDTQIHTHMCYSEFGDILPSIAALDADVISIETTRSNMELLDAFETFDYPNEIGPGVYDIHSPRVPDADEIERLILLALERIPAQRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQKVEEEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RZ5</accession>
    <name>Q63RZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109122.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2526"/>
    <dbReference type="EnsemblBacteria" id="CAH36533">
        <property type="protein sequence ID" value="CAH36533"/>
        <property type="gene ID" value="BPSL2526"/>
    </dbReference>
    <dbReference type="GeneID" id="56596431"/>
    <dbReference type="KEGG" id="bps:BPSL2526"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2853"/>
    <dbReference type="eggNOG" id="ENOG5031D4S">
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    </dbReference>
    <dbReference type="OMA" id="FRLAEHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267490" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9092" checksum="5F912506DF4CECF8" modified="2004-10-25" version="1">MKLLTQLAVASAVAGALAAAATAAFAQNSPGMPGGILNDQFRLNEHPQMQFAASAPTKKYQSGKKSDLRRKGDMGDPNGCNLKCPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S43</accession>
    <name>Q63S43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522378.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109074.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2479"/>
    <dbReference type="EnsemblBacteria" id="CAH36485">
        <property type="protein sequence ID" value="CAH36485"/>
        <property type="gene ID" value="BPSL2479"/>
    </dbReference>
    <dbReference type="GeneID" id="56528701"/>
    <dbReference type="KEGG" id="bps:BPSL2479"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2828"/>
    <dbReference type="eggNOG" id="COG3028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMQFVGK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16331">
        <property type="entry name" value="YjgA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023153">
        <property type="entry name" value="PSPTO4464-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006839">
        <property type="entry name" value="Ribosome-assoc_YjgA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38101">
        <property type="entry name" value="PTHR38101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04751">
        <property type="entry name" value="DUF615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016183">
        <property type="entry name" value="UCP016183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158710">
        <property type="entry name" value="SSF158710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="202" mass="22873" checksum="3E82E15AE5E1A113" modified="2004-10-25" version="1">MPPMTRKTRIQPIEHPGEDADHGYDRPSKSQLKRDMHALQELGAALVELPKDAFKRMPMPEDLADAVREARRITDHEGKRRQLQYVGRVMRSLSADETAALRAALDAQRGVNKAETARLHWIERTREQLLANDDALTAFVREHPSADVQEGRTLIRNARKEAQQGKPPRYFRELFQWIKTASGSASDAPDLSPDADDDDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SB4</accession>
    <name>Q63SB4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="5 9">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Osmoregulatory trehalose synthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">otsA</name>
        <name evidence="10" type="ordered locus">BPSL2410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="5 9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205173.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109002.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2410"/>
    <dbReference type="EnsemblBacteria" id="CAH36413">
        <property type="protein sequence ID" value="CAH36413"/>
        <property type="gene ID" value="BPSL2410"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2410"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2984"/>
    <dbReference type="eggNOG" id="COG0380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYGFSNR"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="52478" checksum="84E206AAECF7E3A7" modified="2004-10-25" version="1">MSRLIIVSNRVAPISEGEPAAGGLAIGVYDALKETGGMWFGWSGEVIASGVPQIRIEEHGPVTFATIGLSRRDYDQYYRGFSNATLWPAFHYRADLIQFDRHEFEGYSRVNVWLAQQLVPLLRDDDVIWVHDYHLIPFARALRTAGVKNRIGFFLHIPFPAAQVLVNVPPHRELVEALCSFDLLGFQTDTDLRAFFEYVEYEAGGTVDRAAHPARVDAFGRTLRAAAYPIGVYPDEIAALAKAGENGRAVKSLAASLRGRQLVMSVDRLDYSKGLVERFRAFEKLLEHETSFRNRVSFLQIAPSTRADLRAYQDIRRQLEGESGRINGRFAELDWAPILYIHRQYERPVLAALYRLARVGYVTPLRDGMNLVAKEYVSAQDPDDPGVLVLSRFAGAACELTGALIVNPIDIGGMADALSRALSMPLAERRARHADMLARLRENNVSVWRDHFLRDLGRQRAASGAGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD5</accession>
    <name>Q63SD5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative arginine N-succinyltransferase, alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527439.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108981.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2389"/>
    <dbReference type="EnsemblBacteria" id="CAH36391">
        <property type="protein sequence ID" value="CAH36391"/>
        <property type="gene ID" value="BPSL2389"/>
    </dbReference>
    <dbReference type="GeneID" id="56528798"/>
    <dbReference type="KEGG" id="bps:BPSL2389"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3013"/>
    <dbReference type="eggNOG" id="COG3138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETDHYID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008791">
        <property type="term" value="F:arginine N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017651">
        <property type="entry name" value="Arg/Orn_succinylTfrase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007041">
        <property type="entry name" value="Arg_succinylTrfase_AstA/AruG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04958">
        <property type="entry name" value="AstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03245">
        <property type="entry name" value="arg_AOST_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03243">
        <property type="entry name" value="arg_catab_AOST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="352" mass="38134" checksum="1DE689887E1495A6" modified="2004-10-25" version="1">MLFVRPGRLADLDALAQMARTAQPVLHSLPHDRAALEARVALSEDSFRAEVDFPGEEFYLFVLEDGATGKLLGTASIVAAAGYAEPFYAFRNDALIHASRELHVNRKIHALTMSHELTGKSRLAGFYVDPSLRGDAAAHLISRARMMYIAANRNRFTPEVFSLLLGVTDETGASPFWEAVGRKFFGRDFAAVEIESGGRSRTFIAEVMPTYPLYVPLLPEAAQRVLGEPNEHALLAYDIHLEEGFEPDRYVDIFDAGPVLTAQVDRTACVTKHAERTVREAAHAHGGTTYLLSGGRGDAFRCVLADLPADGADAPLPADARAALGVADGDTVRCVPLHQRDGQPTDQPGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SP2</accession>
    <name>Q63SP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193226.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108874.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2278"/>
    <dbReference type="EnsemblBacteria" id="CAH36281">
        <property type="protein sequence ID" value="CAH36281"/>
        <property type="gene ID" value="BPSL2278"/>
    </dbReference>
    <dbReference type="GeneID" id="56596072"/>
    <dbReference type="KEGG" id="bps:BPSL2278"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3151"/>
    <dbReference type="eggNOG" id="COG4255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHNIDIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016631">
        <property type="entry name" value="Regulatory_RpfE"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015283">
        <property type="entry name" value="Regulatory_RpfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="358" mass="38490" checksum="149D465B9AB1D632" modified="2004-10-25" version="1">MRAQRLHFLVPFALPSTADAASSLHTLDRPALAKLVARARLVEHTLGEDFQRTLPHERWLARRFGAIADDADDAPLAPYMLVADGGAPGDDTWACVEPVHVRIATDHLVLIDPASLEITGEEAAALLDTARPLIEELGVKVQAPHASRWYLSSPQLAGLAGAAPLRASGRNIEIWLPHETRTGERSRAWMKLQNEVQMAWFRHPVNEARDARGEPAVNSIWFHAQGAMKPVTSPFARVLSRSPGARGLALAAGAAAGGPPAAFDALAAGAASPPDGATLVELDALTTPFIEQDWARWHDALAALERDWFAPALAALAQGRIGELALTLCGDTSAATLAATRGDLRKFWRRRALASLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T16</accession>
    <name>Q63T16_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">BPSL2155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527291.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108750.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63T16"/>
    <dbReference type="STRING" id="272560.BPSL2155"/>
    <dbReference type="EnsemblBacteria" id="CAH36157">
        <property type="protein sequence ID" value="CAH36157"/>
        <property type="gene ID" value="BPSL2155"/>
    </dbReference>
    <dbReference type="GeneID" id="56529037"/>
    <dbReference type="KEGG" id="bps:BPSL2155"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3297"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="29379" checksum="AB2A29DE74302A3B" modified="2004-10-25" version="1">MTYTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAGVEYLTLFAFSSENWRRPNDEVSFLMRLFITALEREVGKLHANGIRLRVVGDLTKFEPRIQALIRRGETKTARNTRLTLTIAANYGGRWDILQATRKLVEEAAREGRAPEIDEDAFARHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTFWPDFDAGALAEALASYTHRERRFGRTSAQLEPQAQDADSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T27</accession>
    <name>Q63T27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RNA methylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191284.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108739.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2144"/>
    <dbReference type="EnsemblBacteria" id="CAH36146">
        <property type="protein sequence ID" value="CAH36146"/>
        <property type="gene ID" value="BPSL2144"/>
    </dbReference>
    <dbReference type="GeneID" id="56595929"/>
    <dbReference type="KEGG" id="bps:BPSL2144"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3309"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ILIFEAK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="4">
        <location>
            <begin position="115"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="27482" checksum="9E3F465EB51DE1AD" modified="2004-10-25" version="1">MKAITSRDNPLYKRLKALAGSTHQQRRGEQALLEGFHLASAYLDAAGQPQLCVVTDGALAHEEARGIVARIEPARVVTLPDVLFGQLSNVVNGVGLLLLVARPAPALPARVAGTSVVLDGVQDAGNVGSILRSAAAAGVERVFCAPGTAYAWSSKVLRSAMGAHFLLDIHEDVDAGTLIERLAIPVALTDSHGARAIYDCDLAGPLAWVFGNEGAGVSARWREAATHRVTIPQPGGMESLNVAAAAAVCLFEQCRQQRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T38</accession>
    <name>Q63T38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552516.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108728.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2133"/>
    <dbReference type="EnsemblBacteria" id="CAH36135">
        <property type="protein sequence ID" value="CAH36135"/>
        <property type="gene ID" value="BPSL2133"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2133"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3324"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WHGTWEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="227" mass="24364" checksum="881EB522134CD7BE" modified="2004-10-25" version="1">MKRSSAEIIQEYGPFPGVDSVHGVTFDGRRVWFACGDKLNALDPASGATQRSIDVAAHAGTAFDGRHLYQIAEDRIRKIDPDTGRVLATIPAPGRGNSGLAWAEGSLWVGQYRDRRIHQIDPETGAILRTIESNRFVTGVTWVDGELWHGTWENDESELRRVDPQTGDVLEALGMPAGVGVSGLESDGGDRFFCGGGNSAKVRAVRRPARDAAAHARSGRAGGSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T83</accession>
    <name>Q63T83_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108683.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2084"/>
    <dbReference type="EnsemblBacteria" id="CAH36085">
        <property type="protein sequence ID" value="CAH36085"/>
        <property type="gene ID" value="BPSL2084"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2084"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2360"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IMRIAME"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="659" mass="72143" checksum="8C187D57B3B99A29" modified="2004-10-25" version="1">MAGSRICRFRLHLTLRYVLWLVDIDDGDRMRLKIGELAKKVGLSVRALHHYDAIGLLSPSQRTDGGARLYGRDDLIRLHRIEALKRFGYSLPAIQASLDGPPAGAPLQILRRQIAALDAQAARAQRLSRHLQHLVAMVAAGGETAAIDWLNVLELMNMYQKHLDDNELDTLLASGPDTVAPMDPSWVGLVDEVRDAMRRALPADSDAAQALAWRWSRLMNRMTRNDPALAGKLMGIQLGEPRAQHIVGITPAMLTWIGEACAHARCTLFAKYLNPAQIAEVRRRQLADTHMHAWLALVAELRAHMEAGVDAGAAPVQAIVARWQQLFRDSFCGEDEGLEAKVRDALMREPDLQLGGGFDEALLVYLNKAHIAGRDIASGDDGPKPSALMVAKQRAAHQLLDRPLVLDDPIALSILGAAEEQALRADLDRFRYPASLGMRSSVVVRSRLADDMRAEAIGRGVRQYVVLGAGLDTSAYRHPEAPGRLFEVDLPATQRWKQARLREAGIAPPRSLRFVPVDFEHVSLADGLARAGFDPGAPALFSWLGVTMYLDEAAVVETLRFIAGCAKGSAVLFEYVTPLSGLPPMMRIAMEQLTAQLAARGEPWKCFFEPAALAEMLVGLGFGSIGAWSPDELNRRYLADRADGLHIGATPARLILATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TC8</accession>
    <name>Q63TC8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526758.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108638.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2041"/>
    <dbReference type="EnsemblBacteria" id="CAH36040">
        <property type="protein sequence ID" value="CAH36040"/>
        <property type="gene ID" value="BPSL2041"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2041"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.24"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NADAQHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028244">
        <property type="entry name" value="T6SS_Rhs_Vgr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018769">
        <property type="entry name" value="VgrG2_C_DUF2345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10106">
        <property type="entry name" value="DUF2345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13296">
        <property type="entry name" value="T6SS_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="2">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS_Vgr" evidence="4">
        <location>
            <begin position="590"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2345" evidence="3">
        <location>
            <begin position="752"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="946" mass="99069" checksum="AB8A66234B14ADC1" modified="2004-10-25" version="1">MSIPTDVLQALFGGWSQHDRFLWITTPLGANALVAESLHGWEALDDGGFRLQLTALAEHPSLPLAQLIGAPILIEWQAQEGRDARRPFHGHVIAAELVGYNGGLARVRLVVEPWLTLLRQRVDSYNYLDASVVEISEQVFRRYARGVIAPAWRWALADAAKYPKRSLTAQAGESDFDFLERLWAEEGIFYWFEHEGDARASSLGKHTLVLADSNQRFAPDEPEIVGFHQTSDDDPQGCIQHFMHARRWRIGSVARASWDHRSLSTRPTGARANGAVAPGEDRDVAGPYAYQTGAIGDRRAQQQLDAQRVAALRSEGRSTRRDLRPGLRFAIAHHPTLGVSDAFICLRVEHSARANVDATVRSAIEQRLGAIASIAGAAPVPHGPASALNAALGADTHHGGSLMRDDAVYRNRFVALPAEQTYRPLAASGHGARMHPVAVMPGAQTAIVVGAGDPVHTDRDHRIRIQHHAQRGENAASRDDHPHAANAPANRGAGTWTRMMTPVGGDNWGGVSVPRVGQEVWTEWLEGQPDRPVAVAALYNGRGNAHAQHNAQAGGPSGSTGNAAAWFAGNAHAAVLTGFKTQDMSMSQQGTGGYRQFMLDDTAGQSSARLYTTDRNSGLTLGHVKQTQDNRRQADRGYGAELATDAAGALRGGAGLLISTAPGVSQMDASAPSQVLAQHRQTLQSLAALAHKQGAEPGGAVPEAAGGAGAASASTGAAADKPLPAVDGIEQSREAIGATREGSGGDTAGGGGGGAIAWSKPHLVAHGEAGLAAMSAKSHVWVSGTETVLSAGQDVQLTAKGKTSVVANHGISLYTQGAAGDGRPVAGRGIALHAASGAVSVQAQNAGKLSASAQKAVTLASAQGSASVQAQQRVLLSAAKAYLKMEGNDIVVGAPGRADFKAAAHQLTGPKSAGASAQMPKSEPKLCEYKTRAADVAHEGTMKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TE0</accession>
    <name>Q63TE0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526783.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108626.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2029"/>
    <dbReference type="EnsemblBacteria" id="CAH36028">
        <property type="protein sequence ID" value="CAH36028"/>
        <property type="gene ID" value="BPSL2029"/>
    </dbReference>
    <dbReference type="GeneID" id="56595365"/>
    <dbReference type="KEGG" id="bps:BPSL2029"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2289"/>
    <dbReference type="eggNOG" id="COG5430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FQCTPGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007893">
        <property type="entry name" value="Spore_coat_U"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05229">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00972">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCPU" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="174" mass="17049" checksum="FDD979BEA74156D2" modified="2004-10-25" version="1">MSTLQRVLFLLGVAAWPAAGRADTLLPRTQAFTVSAQIVAGCGVAGGGPASGLNFGTLDFGAHPAVATGQVSAAVGGGALQIECSPGSTLKMTIDGGANASAGNTQRNLASGGARVAYRLYSDPARTQAIAVGQAVSLPVSGTITLPIYGALTLPGGGAPAGTYTDTAQVTLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TF3</accession>
    <name>Q63TF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane attached glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108613.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2015"/>
    <dbReference type="EnsemblBacteria" id="CAH36014">
        <property type="protein sequence ID" value="CAH36014"/>
        <property type="gene ID" value="BPSL2015"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2015"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2273"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAFRYWC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267538" evidence="5">
        <location>
            <begin position="21"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="6">
        <location>
            <begin position="42"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="7">
        <location>
            <begin position="440"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="682" mass="73126" checksum="7E4DD5B8D016A6A1" modified="2004-10-25" version="1">MRKKSLVHLPVALAVAAALGACSGDDDATLESRADAIVERMTTRQKVGQKLMMAFRYWCPDGQPACTTGMTEFPDAARDALRENGIGGVILFSNNLTGIEQTRRLIDGIRAAPAADSPLGLMIGIDEEGGNVFRLPRVEATAFAGNMALGAAYEATRDDRLAYDMGRVLAAEIAAVGFNVNFAPDVDVNSNPLNPVINVRAFGDDPATIGLLGRRMVQGMKSERVIGTFKHFPGHGDTDTDSHYGLPVVIKSRADAYAIDLAPYRQAIEAGEAPDMIMTAHIQYPSLDDTRVATRTGEQMIAPATMSRRIQHDILRGEFGYQGVTITDALDMKGIAGFFDEDDAVVKVFQADVDIALMPVEFRTAADAGRLAALVDRVAAAVDSGRIDRAEFDRSVRRIVLTKLRHGIVASDRGRPVDELASIGGPAHRAIERDIAQKSITVLRNENGALPLQAAGRRIFILTPWGEQAEAMRRRFVELGHPLVTGAKLSTITWAEQQQAIDAADVVIVGTLSTGVTPVEHNGDPNARVSPPAPSAVRMRQAAPANGEEEGSVIFDHVERADAAKDIGARPSVLAAIAAPSEAQQMRDAMDYAKARRKTVIHVTMRAPYDVISYDDVADATLATYAYYGYEGGLRGPSLPAAVDAMLGVARPVGRLPVAIHALNADGSTGPLRYARGFGLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TF6</accession>
    <name>Q63TF6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="9">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">glnS</name>
        <name evidence="13" type="ordered locus">BPSL2012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193654.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108610.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2012"/>
    <dbReference type="EnsemblBacteria" id="CAH36011">
        <property type="protein sequence ID" value="CAH36011"/>
        <property type="gene ID" value="BPSL2012"/>
    </dbReference>
    <dbReference type="GeneID" id="56595382"/>
    <dbReference type="KEGG" id="bps:BPSL2012"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4168"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INNFCAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="32"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="12">
        <location>
            <begin position="353"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="281"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="45"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH36011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="569" mass="65220" checksum="28EECB17807CD182" modified="2004-10-25" version="1">MSTERNDATAPSNFIRNIIDDDNRTGKWSGRVETRFPPEPNGYLHIGHAKSICLNFSVARDYGGVCHLRFDDTNPEKESVEYVNSIVDAVRWLGFDWQKAGVDHQYFASDYYDKLYEFAELLIQRGCAYVDSQSADEMRTNRGSLTEPGTPSPFRDRSPDENLALFRRMKAGEFAEGEHVLRAKIDMSSPNMNMRDPVIYRIRYAHHYRTGDKWCVYPMYDYTHCISDALEGITHSLCTLEFEDHRPLYDWVLNQLADAGVFARPLPQQIEFSRLNLTYAITSKRKLLQLVTEGHVDDWDDPRMPTIVGVRRRGFTPESIQLFCERIGVTKVDSWIDMSVFEGALRDDLDDKAPRTVAVLDPLKLVIDNYPQGQSEECTAPVHPHHPERGQRTFPISRELWIEREDFSEHPPKGYFRLFPGNKVRLRYGYVIECTGADKDEHGNVTAVHCNYYPDSKSGTEGANNYKVKGNIHWVSAAHACPAEVRIYDRLFKEPHPDAGGRNFLEALNPDSKKIVQAYLEPGARDALPEARYQFERHGYFVADRVDSKPGQPVFNRIVGLRDSWGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TI7</accession>
    <name>Q63TI7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 6">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">galU</name>
        <name evidence="8" type="ordered locus">BPSL1981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192544.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108579.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1981"/>
    <dbReference type="EnsemblBacteria" id="CAH35980">
        <property type="protein sequence ID" value="CAH35980"/>
        <property type="gene ID" value="BPSL1981"/>
    </dbReference>
    <dbReference type="GeneID" id="56595416"/>
    <dbReference type="KEGG" id="bps:BPSL1981"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4133"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="293" mass="32404" checksum="47496408A8035B7A" modified="2004-10-25" version="1">MLKVTKAVFPVAGLGTRFLPATKASPKEMLPVVDKPLIQYAVEEAIAAGITEMIFVTGRSKRAIEDHFDKSYEIEAELEARGKEKLLDLVRSIKPSHVDCFYVRQPEALGLGHAVLCAEKLVADNPFAVILADDLLDGDPPVMKQMVDVFDHYHSSVIGVEEIPPEDTKSYGIVDGKEWEDSIIKMSAIVEKPAPEVAPSNLGVVGRYVLKPRIFDHLRALKPGAGGELQLTDAIQALLADEQVLAYKYRGTRFDCGSKLGYLKATVEFALRHPEVKTEFETYLRSRSETQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TR3</accession>
    <name>Q63TR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported heme utilisation related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550550.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108503.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1903"/>
    <dbReference type="EnsemblBacteria" id="CAH35903">
        <property type="protein sequence ID" value="CAH35903"/>
        <property type="gene ID" value="BPSL1903"/>
    </dbReference>
    <dbReference type="GeneID" id="56526271"/>
    <dbReference type="KEGG" id="bps:BPSL1903"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4047"/>
    <dbReference type="eggNOG" id="COG2831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TPYIAYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005565">
        <property type="entry name" value="Hemolysn_activator_HlyB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03865">
        <property type="entry name" value="ShlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266312" evidence="1">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA_2" evidence="3">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ShlB" evidence="2">
        <location>
            <begin position="231"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="559" mass="60260" checksum="90D140BC1278A5B6" modified="2004-10-25" version="1">MKSRHDAWMLLLALVAAAGAAHAQSRSGGNPLEALPQINTPQKPSVTVQVAPQEVQVQALLARHLTPSSFQVEGVKSIPFEEISQRFTPLVGKDITIGQLIETANGVTKLYQERGYALSFAFVPAQTFEGGVVRVTVVEGYVANLKITGRPGAMEPKVRAIAAHIMADRPLRRATFERYVNTFGLLPGVTVKANVPPPQNTDGATTLELNVDRKPFNVSAGLNTNNPGLQGLFTVTENGLTSLGEQMSISALFPKGPNNQTYVSFNGAVPIGSNGLVTRLDASHYRGNPSVDQTVLPNVQRTVINDKLGLSASYPLMLSNQRSLLGTVSGYASHSEDRYQNQSTGATIGMRSQVRVLQMQFDYTSVQPKQVQKLSFNVAKAFDILGASKSGFTNLPGVIATNPASTTFVRTGATFVQTNEWPFKIGSTVQLTGQYSPDSLPSTEQISFGAQRFALGYQPGETSGDSGWGASLELNRAFAPGFTYLKNITPYIVYDMARVYLHSGTPVPRRLSSAGFGVRLTDSRFYNLDVSIAKPVGDAPIESASRSPRVNASFSYQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TR8</accession>
    <name>Q63TR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family A24A unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521660.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108498.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1898"/>
    <dbReference type="EnsemblBacteria" id="CAH35898">
        <property type="protein sequence ID" value="CAH35898"/>
        <property type="gene ID" value="BPSL1898"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1898"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4041"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPALARW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="4">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="166" mass="17186" checksum="3E13A79413021D46" modified="2004-10-25" version="1">MIHLFSIGFFFAWAAAVAIADCRDRRIPNELVLVGLAAVIIFTVCRQNPFGTTLSGALIGGAVGLVSLFPFFALRVMGAADVKVFAVLGAWCGLPALPRLWVVASVAAGVHALALMLLTRTPPGSLGRGGAPAFALGARRAAPYAAFLVAPAAAWLAYLIHTGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U15</accession>
    <name>Q63U15_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multidrug efflux system putative membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108401.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63U15"/>
    <dbReference type="STRING" id="272560.BPSL1802"/>
    <dbReference type="EnsemblBacteria" id="CAH35801">
        <property type="protein sequence ID" value="CAH35801"/>
        <property type="gene ID" value="BPSL1802"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1802"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3921"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ILQDRNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="516" mass="55139" checksum="0E125AF9FC3CD5CD" modified="2004-10-25" version="1">MKAMMKPRARRRGARAARRPNGPRAWPLAVAAALVAGCTLAPRYERPAAPVPAHYWSTATGAPREAGPAAAGGPRAMPDARRGDAGRDARDARLDDWRAYFTDPALRALIDAALANNRDLRIATLRIQEARGLYGVARADRLPSIDGSLGYERTRLYDPVLRESATSSLYRASVGVSAFEIDLFGRVKSLSDAALAEYFATAEAQRAARISLIAEVASAYVTERALVDQLGLAERTLAARDAAYALTQRRYAAGTSTAIELRTAEMLVASARASKAALEREHTQAASALKLLAGDFMTALPADAPALDALAVARVSPGLSSDLLEQRPDIRQAEQRLVAANANIGAARAAFFPRIALTTDVGSVSDAFSGLFSAGSSVWTFAPRLTLPIFAGGRNRANLDVADARKHIAVAEYEKTIQTAFREVADALAARDQIDAQLAAQQAVYGADAERLRLAQRRYDSGVASYLELLDAQRSTFESGQELIRLKQLRLTNAITLYRALGGGWSRAGCGGDGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U23</accession>
    <name>Q63U23_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108393.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1794"/>
    <dbReference type="EnsemblBacteria" id="CAH35793">
        <property type="protein sequence ID" value="CAH35793"/>
        <property type="gene ID" value="BPSL1794"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1794"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2017"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEITIQF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="37740" checksum="AB7B24B309925481" modified="2004-10-25" version="1">MVRRNKEERVQPDLEVVDVRRGESFKAWSHGYPYRTVRWHFHPEFEVHLIVETTGQMFVGDYVGGFGPGNLVLMGPNLPHNWVSDVPEGRTIAERNLVVQFGQAFVSRCADSFTEWRHVEALLADARRGVQFGPRTSEAIKPLFAELIHARGLRRIVLFLKMLQILIDATDRELLASPAYEADASSFASTRINHVLAYLGKNLANELRETDLARLAGQSVSAFSHYFRRHTGLPFVQYVNRMRINLACQLLMDGDASITDICFRSGFNNLSNFNRQFLAVKGMSPSRFRRYQALNDASREASEAAALRGAGIAGAPAIVPAARARGEARAPAEVLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U24</accession>
    <name>Q63U24_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar-binding exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108392.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1793"/>
    <dbReference type="EnsemblBacteria" id="CAH35792">
        <property type="protein sequence ID" value="CAH35792"/>
        <property type="gene ID" value="BPSL1793"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1793"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2016"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QELNNEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266584" evidence="1">
        <location>
            <begin position="36"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="40"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="314" mass="32595" checksum="A272A5FBAE29BB23" modified="2004-10-25" version="1">MHTALSTPASGRRAARALRAAALSLALGAASAAHAAPLKIGMTFQELNNPYFVTMQKALDEAAASIGAQVIVTDAHHDVSKQVSDVEDMLQKKIDILLVNPTDSTGIQSAVVSAKKAGAVVVAVDANANGPVDAFVGSKNFDAGAMSCDYLAKAIGGGGEVAILDGIPVVPILERVRGCRAALAKFPNVRIVDVQNGRQERASALAVTENMIQAHPLLKGVFSVNDGGSMGALSAIEASGRDIKLTSVDGAPEAIAAMQKPNSKFIETSAQFPRDQIRLAIGIGLAKKWGANVPKAIPVDVKRIDKGNAKTFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U32</accession>
    <name>Q63U32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative iron transport-related ATP-bidning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526941.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108384.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1784"/>
    <dbReference type="EnsemblBacteria" id="CAH35783">
        <property type="protein sequence ID" value="CAH35783"/>
        <property type="gene ID" value="BPSL1784"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1784"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3892"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHQVELM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="296" mass="31455" checksum="5F3342C913E8C7C6" modified="2004-10-25" version="1">MNNETVAALAARALSVGYRDHRVLDGLDLTIAAGRVTALCGPNGCGKSTLLRTLAGLQPALSGTVDVNGAPLGSYRRRALARTLTMLAQFNQIPAGLTVRELVAYGRYAHGGWLRGLARADRDAIDEALAATGLEPDAARDVAALSGGERQRAWIAMALAQQAPIVLLDEPTTYLDIHHQLDILRELRRLNRARGLTIVWVLHDLNQAAAYSDEIVLMRAGRIVAQGTPDAMLEPRHLQAAFGVTMLKTAHPLTGAPMCVPAYEGVLDTDHADPAHAAAPGVRGAAVARARRDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U43</accession>
    <name>Q63U43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobyrinic acid A,C-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobB</name>
        <name evidence="7" type="ordered locus">BPSL1773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205066.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108373.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1773"/>
    <dbReference type="EnsemblBacteria" id="CAH35772">
        <property type="protein sequence ID" value="CAH35772"/>
        <property type="gene ID" value="BPSL1773"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1773"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3879"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPFKCGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="340"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="535" mass="54736" checksum="CB2B8275E1B4AAC3" modified="2004-10-25" version="1">MPACPALFVAAAASGQGKTSVTAALARHHRRLGRRVRVFKTGPDFLDPMLLARASGARVYSLDLGMVGERGCRALLARAAAEADVILIEGAMGLFDGTPSSADLAQAFGVPVAAVIAAQSMAQTFGALAFGLAHFRPGLPFHGVLANRVGSERHAQLLRGALPGSIRWLGHLPRDARIALPERHLGLHQPDDVADLDARLDRAADAIAHTALAALPPVVEFACGDAANAEADAGDGGATIPARDASRTAHRTATAARVAAGRGALAGATMRAAHGERAARSADAAAYETVDDALLDAAKRAGTGDGALSPSPDAGGAIGAIGAIRSTETTEAVPSLVGCRIAIARDAAFSFIYPANLDQLEALGAELAFFSPLADEPVPDGSHALYLPGGYPELHAARLAANATAARSIAAHVAAGRRVVAECGGMLYLSDALTDADGVTTPMLGLVPGHATMQRRFAALGMQTLATRFGAMTGHTFHYSRLATPLAPVAAATRPDDGAAGEPVYRHGPIVATYLHAYWPSNPRAAAALFAGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UH0</accession>
    <name>Q63UH0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108246.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1632"/>
    <dbReference type="EnsemblBacteria" id="CAH35631">
        <property type="protein sequence ID" value="CAH35631"/>
        <property type="gene ID" value="BPSL1632"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1632"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1842"/>
    <dbReference type="OMA" id="LILMEHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="18045" checksum="47939E7850F26C14" modified="2004-10-25" version="1">MILMEHTTSIGWAARSHARSEHACDRISQWILVLMPIVFVAFCVLLISLWYIDILTGWLIAAFALLIEAMLIGIGFFVFVMARISHRRRREREAKTALCRANQPDDADVPFPVGFDGVKTVHCMFGSGQVGAFRVSCYNTNCPLMRGATETERLPGQAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UY0</accession>
    <name>Q63UY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193771.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108086.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1464"/>
    <dbReference type="EnsemblBacteria" id="CAH35466">
        <property type="protein sequence ID" value="CAH35466"/>
        <property type="gene ID" value="BPSL1464"/>
    </dbReference>
    <dbReference type="GeneID" id="56595800"/>
    <dbReference type="KEGG" id="bps:BPSL1464"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3494"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMFVAWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="336" mass="35595" checksum="C0D396DEE3D9B2A8" modified="2004-10-25" version="1">MHSIQLALWVVAALVLVALVFDFMNGFHDAANSIATVVSTGVLKPQQAVVFAAAFNVIAYFIFHLKVAQTVGKGTIDASIVDHYVVFGALFGAIGWNIITWYYGIPSSSSHALIGGLVGAAVSKSGWGSLNVDGLMKTVAFIFISPLLGFILGSLFMLGVSWLYFRTAPSKVDRRFRRLQLLSASLYSLGHGGNDAQKTIGIIWMLLIASGYASAASDAPPAWVIGACYLSMGLGTLFGGWRIVRTMGQKITKLKPVGGFCAETGGALTLFIASWMGIPVSTTHTITGAIVGVGATRKLSAVRWGVAGNIVWAWVLTIPASALIAAAGWWIGHRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V38</accession>
    <name>Q63V38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196624.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108028.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1406"/>
    <dbReference type="EnsemblBacteria" id="CAH35407">
        <property type="protein sequence ID" value="CAH35407"/>
        <property type="gene ID" value="BPSL1406"/>
    </dbReference>
    <dbReference type="GeneID" id="56595859"/>
    <dbReference type="KEGG" id="bps:BPSL1406"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3421"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRGMETS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="109" mass="12355" checksum="F73710BE9E7D7DC4" modified="2004-10-25" version="1">MKLPLEISIQGMPRSAALEEAIARHAAKLERYCAEIIRCRVSVILDDKHKHQGKPFDVHVDVTIPGREIVSNRESDEDVYVALRDAFGNAERMLDDAASKRRDQTRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V77</accession>
    <name>Q63V77_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate regulon transcriptional regulatory protein PhoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phoB</name>
        <name evidence="10" type="ordered locus">BPSL1364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192125.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107989.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1364"/>
    <dbReference type="EnsemblBacteria" id="CAH35362">
        <property type="protein sequence ID" value="CAH35362"/>
        <property type="gene ID" value="BPSL1364"/>
    </dbReference>
    <dbReference type="GeneID" id="56595291"/>
    <dbReference type="GeneID" id="66546808"/>
    <dbReference type="KEGG" id="bps:BPSL1364"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.116"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011879">
        <property type="entry name" value="Sig_transdc_resp-reg_PhoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02154">
        <property type="entry name" value="PhoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="26084" checksum="256D31AEC756A249" modified="2004-10-25" version="1">MPSNILVIEDEPAISELISVNLQHAGHCPIRAYNAEQAQSLISDVLPDLVLLDWMLPGKSGIAFARDLRNNERTKHIPIIMLTARGDEQDKVLGLEIGADDYVTKPFSPKELMARIKAVLRRRAPQLTEDVVSINGLRLDPATHRVAAQSDGSEIKLDLGPTEFRLLHFFMTHPERVHSRTQLLDQVWGDHVFVEERTVDVHIKRLRAALKPAGCDAMIETVRGSGYRLAKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V91</accession>
    <name>Q63V91_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transport-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192135.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107975.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1350"/>
    <dbReference type="EnsemblBacteria" id="CAH35348">
        <property type="protein sequence ID" value="CAH35348"/>
        <property type="gene ID" value="BPSL1350"/>
    </dbReference>
    <dbReference type="GeneID" id="56595277"/>
    <dbReference type="KEGG" id="bps:BPSL1350"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.130"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGVWCGD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="220" mass="23336" checksum="D91F27AAB6C950CF" modified="2004-10-25" version="1">MFGHALGITDLWTYVFGVVFIILLPGPNSMYVLSLAAQRGVKAGYRAACGVFVGDTVLMVLSAAGVASLLKANPLLFSVVKYGGAAYLLYIGVGMLRGAWRKLARPAADAGADVRRAVDGERPFRKALVVSLLNPKAILFFISFFIQFVDPAYAHPALSFVVLGAIAQLASFVYLSTLIFTGARLADHFRRRRKLAAGASGGVGGLFVGFSVKLALATMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VC1</accession>
    <name>Q63VC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937029.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107945.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35318">
        <property type="protein sequence ID" value="CAH35318"/>
        <property type="gene ID" value="BPSL1321"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1321"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.169"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="491" mass="54000" checksum="8243547C9F688BB7" modified="2004-10-25" version="1">MKRYETLARAMADDIRSGNITTGTRMPSLRQMIAQHRVSQSTVFRAYYLLEQWGLIRARERSGYYVAHGAQASVRANGMNGMNGAHATQDGRLTRDAAPAESRKVDISDLVFSVLEAATHPRIVPLGSAFASPHLFPLPRLAKSLAQAARLVSPWSAVVDLPPGSEQLRRQIALRYLGIGVSQPIDEIVVTNGALEALNLCLTAVTRPGDVVAVEAPGFYAALQAIERLDLRAVEIPVDPRTGLDLDALAAALERHDVRACWFMTNFQNPTGVTLSADKKKALVDMLAAREVPLIEDDVYGELHHGPDYPLPARAFDKHGLVMHCSSFSKTLAPGYRIGWAAAGRFAEKVQRLKLMTTLSASIPAQVGIADYLEHGGYDRHLRKLRGALRGQMERMNDALMRHLPPDVHWTLPDGGYFVWLEFPDAIDAMGLHREAIRRGVSVAPGPLFSAAHAFERCVRINFGHPWSAAVDDAIRTVGELVTQPSVRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VM9</accession>
    <name>Q63VM9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NADH dehydrogenase I chain E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185492.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107837.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1215"/>
    <dbReference type="EnsemblBacteria" id="CAH35210">
        <property type="protein sequence ID" value="CAH35210"/>
        <property type="gene ID" value="BPSL1215"/>
    </dbReference>
    <dbReference type="GeneID" id="56595149"/>
    <dbReference type="GeneID" id="66546651"/>
    <dbReference type="KEGG" id="bps:BPSL1215"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.311"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MYDTKPV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="17571" checksum="FB37A71187CBF615" modified="2004-10-25" version="1">MISAEGLKEIDRAIAKYPADQKQSAVMSALAVAQEEHGWLSPELMQFVADYLGMPAIAVQEVATFYTMYELAPVGKHKITLCTNLPCQLGPHGGAEATADYLKQKLGIDFGETTPDGKFTLKEGECFGACGDAPVLLLNNHKMCSFMSREKIDQLLEELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VP0</accession>
    <name>Q63VP0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="BPSL1204"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2913">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266625" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="166" mass="19189" checksum="CB2BD530569FA7D1" modified="2004-10-25" version="1">MFARLPVLFACAAALLAGCAQPWQQFHAGDDSSAIVARLGPPREIYDLPNGGKRLMWPTQPMGEVTTAADIDAHDRIVSVRQVLQPLEFYRAEIGKWTKTDVLVNFGRPVETSYFPLMKREVWTYRYLEDNVWYMLYSFYFDDDGILRLTQKTPDPLHDPDRRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VY2</accession>
    <name>Q63VY2_BURPS</name>
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        <submittedName>
            <fullName evidence="7">Putative exported protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">BPSL1113</name>
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        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1113"/>
    <dbReference type="EnsemblBacteria" id="CAH35106">
        <property type="protein sequence ID" value="CAH35106"/>
        <property type="gene ID" value="BPSL1113"/>
    </dbReference>
    <dbReference type="GeneID" id="56595062"/>
    <dbReference type="KEGG" id="bps:BPSL1113"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.437"/>
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MliC"/>
    </dbReference>
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        <property type="entry name" value="MliC_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5004267204" evidence="5">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="MliC" evidence="6">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="13733" checksum="904493E8025C546E" modified="2004-10-25" version="1">MNRKTRAAIGVAALCAAAGAAHAARLTVEEIDADARETVAYRCANAPKPVRVSYWRAGNGQSFALVPVNGVRLLFVDTVSASGARYQAGRYVWWTKGRDANLYDEIAGERAPPVLADCSEVRKPRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VY8</accession>
    <name>Q63VY8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1107</name>
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    <organism evidence="3 4">
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            <taxon>Bacteria</taxon>
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            <taxon>Betaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186147.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1107"/>
    <dbReference type="EnsemblBacteria" id="CAH35100">
        <property type="protein sequence ID" value="CAH35100"/>
        <property type="gene ID" value="BPSL1107"/>
    </dbReference>
    <dbReference type="GeneID" id="56595054"/>
    <dbReference type="KEGG" id="bps:BPSL1107"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.446"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFVLTWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="219"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="610" mass="68231" checksum="9DD7A500243EA6F3" modified="2004-10-25" version="1">MPALIEDYALVGDGHTAALISRDGSVDWLCWPRFDSGACFAALVGTPEHGRWLVAPADDVRVSATSRRYRGDTLILETDYECDEGAVTVIDFMPPGSGWSELVRIVVGRRGEMRMQMQLVLRFDYGFSVPWVTRLPREAGVKAIAGPDTVVLRTPVPLSGENLHTVAEFTVKAEERVPFSLSYAPSHLRLPPAREPLSMLARTENYWLEWSARCPLRGRYASAVRRSLITLKALAYEPTGGIVAAPTTSLPEQLGGTRNWDYRYCWLRDATITLLALMRGGYYDEARAWRTWLGRVMAGSPEQIQIMYGIAGERRLPEMELDWLPGYQDSRPVRIGNNAANQLQLDVFGEVMSALHIARVGGLQADDTVWSVQTTLLAHLEKIWREPDEGIWETRGGRRHFTFSKVMAWVAFDRAIKSAEMFRLSAPLERWRAIRDEIHADVCANGWNPRVRAFTQSYGSDALDASVLMLPLVGFLPPDDPRIADTVEAIERGLMRDGLVLRYHTTEYDDGLPPGEGTFLACSFWLVDNLALLGRIDDAHALFRRLLSLTNDLGLLAEEYDPVTRRQVGNFPQAFSHVGLVHTAFNLMHHEEEMLRAAGQPAAADAVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W27</accession>
    <name>Q63W27_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rubA</name>
        <name evidence="8" type="ordered locus">BPSL1066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186320.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107689.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1066"/>
    <dbReference type="EnsemblBacteria" id="CAH35061">
        <property type="protein sequence ID" value="CAH35061"/>
        <property type="gene ID" value="BPSL1066"/>
    </dbReference>
    <dbReference type="GeneID" id="56594784"/>
    <dbReference type="KEGG" id="bps:BPSL1066"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.494"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSAYRCP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="60" mass="6752" checksum="F64C3CAE8EC65D9C" modified="2004-10-25" version="1">MSEVVEYKSWVCLICGWIYNEAEGLPDEGIAAGTRFADIPHGWRCPLCDVGKEDFVVVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W56</accession>
    <name>Q63W56_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522523.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107660.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1034"/>
    <dbReference type="EnsemblBacteria" id="CAH35029">
        <property type="protein sequence ID" value="CAH35029"/>
        <property type="gene ID" value="BPSL1034"/>
    </dbReference>
    <dbReference type="GeneID" id="56526805"/>
    <dbReference type="KEGG" id="bps:BPSL1034"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.533"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERGYADH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="5">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="6">
        <location>
            <begin position="146"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="232" mass="25448" checksum="2A2BCA6A90B7DD9E" modified="2004-10-25" version="1">MFEIRRAGDRGHADHGWLDTHHSFSFADYRDPEHMHFGALRVLNDDRIAPTRGFGMHPHRDMEIVTYVLEGALAHRDSMGNGSIVRAGDVQRMSAGTGIVHSEYNASRDAPLHLLQIWLLPVEPGGRPGYQEARFTDADKRGRLRLVASPDGRDGAVTVRADASIYAGLVDGDERAEFALPAGRRAYVHVARGCVVVNGEMLAAGDGARIAEVGRVVFERGERAEVLLFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WM1</accession>
    <name>Q63WM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107495.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0870"/>
    <dbReference type="EnsemblBacteria" id="CAH34862">
        <property type="protein sequence ID" value="CAH34862"/>
        <property type="gene ID" value="BPSL0870"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0870"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.939"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAWDFVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021969">
        <property type="entry name" value="DUF3579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12112">
        <property type="entry name" value="DUF3579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="111" mass="12418" checksum="701F1086B68D5418" modified="2004-10-25" version="1">MGTLMAETLPTEYFIQGITKDGKKFRPSDWSERLAGVMSCYGPGASGPNARLQYSRYVRPTLLGDLKCVIVDARLRDVEPMAFDFVMNFAKDNNLVVTEACELPDYGKTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WT7</accession>
    <name>Q63WT7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522678.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107429.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0804"/>
    <dbReference type="EnsemblBacteria" id="CAH34796">
        <property type="protein sequence ID" value="CAH34796"/>
        <property type="gene ID" value="BPSL0804"/>
    </dbReference>
    <dbReference type="GeneID" id="56527017"/>
    <dbReference type="KEGG" id="bps:BPSL0804"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.800"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HSSQHYN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="305" mass="35194" checksum="1A229F945202B32B" modified="2004-10-25" version="1">MQFNVELLLLALAPVFLLCIGWEAWHLARTRPGEHVYNLRDTLCNAALALMHQGADKIAWIFVIPVYAYCYAHYRLVTWDATWIAFAVLFVAQDLLYYVFHRCSHRVRWLWAAHVVHHSSERLNFSTAMRQSLMYPIAGMWAFWLPLAFLGFPPQQIVGIVLINLAFQFFVHTQTIPKLGWLEYVLNTPSIHRAHHARNPRYIDRNYAGVLVIWDRLFGSYVDEDPRDPPEYGIVEPLRSNNPLVATFHEWRSMAADAIGVEGWRNKLRAVFGPPEWASAYHARVAHARAQSDEPPALAAAPRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WZ8</accession>
    <name>Q63WZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107368.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0742"/>
    <dbReference type="EnsemblBacteria" id="CAH34734">
        <property type="protein sequence ID" value="CAH34734"/>
        <property type="gene ID" value="BPSL0742"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0742"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.812"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANCATVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045535">
        <property type="entry name" value="DUF6430"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20016">
        <property type="entry name" value="DUF6430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6430" evidence="2">
        <location>
            <begin position="83"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="30892" checksum="CF5C0D22A47AB45E" modified="2004-10-25" version="1">MNSIRDLLNGVRRHPVKMLAYMFTAFSIIQTVVRGVSLFVPGISISGPIPFAAVIVISVSWGLKKVWKPSRIELPIANCATVIEVVFGDLFEQEGIRAIAVNNFFDSALGKPVSDKSVHGIFLKKCFGGHAEPFDKQVDEQLAAIESESVERAEGKTKRFPIGSTAMINVNQDRYIAFAFAETDPATSKAHSDVTMMWSALHSLWERARVEAGGHSLNLPLVGSGLSGLGLPTRDLLNLIILSAITETKTREVTQRIRIVLGRDRFDHLDLRDVKAHWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X35</accession>
    <name>Q63X35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540956.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107331.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0702"/>
    <dbReference type="EnsemblBacteria" id="CAH34695">
        <property type="protein sequence ID" value="CAH34695"/>
        <property type="gene ID" value="BPSL0702"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0702"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.915"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYSFRVS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="3">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="190"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="560" mass="60693" checksum="E409A70139E186AE" modified="2004-10-25" version="1">MSNKPAPDAPPAEQPCAVSRRGFLKFAGVSGLASAARGLAATRAAAAAPDGTPEQIHLTWGDADANEVVVSWASLAAATNPRVRFAGPNEAWRTVHGVQRTYTDGLNGEVVFTYHARLRGLKPGAVYRYEVTADNDANAAQPFAARFETAPRGRAPFRWTSYGDLATPNTGWVLSSPQSRFAVQAVERFQPLFHLLNGDLCYANLNPAHQPAVWRDFGNNNQTSAANRPWMPCPGNHEIEFHNGAQGLDSYLARYTLPENGTRFAGRWYSFRVGAVLFVSLDADDVVYQDAAAFVAGPNPLVPAASTGNEAIAPGTSLYVRGYSRGEQTRWLEQTLRRASRDRDIDWIVVQMHQDALSSSKTGNGSDKGIREAWLPLFDRYGVDLVLCGHDHDYERSFPVRGCNHRAGVDAATGEVVDTLQPRPVVTTDPADGRFDTSHGTIHMILGGGGTSAPLDVYGENPATGLPQARVFTKPNRPVPGAAPNTFVRHGADAVEDAIWSARRDTGTGYGIAVFDYEPGEHGGRSTITVNYYHAPGADQHPTAEYELFETIVLSKPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X66</accession>
    <name>Q63X66_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glutathione = 5-oxo-L-proline + L-cysteinylglycine</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189235.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107300.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0671"/>
    <dbReference type="EnsemblBacteria" id="CAH34664">
        <property type="protein sequence ID" value="CAH34664"/>
        <property type="gene ID" value="BPSL0671"/>
    </dbReference>
    <dbReference type="GeneID" id="56596634"/>
    <dbReference type="KEGG" id="bps:BPSL0671"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.949"/>
    <dbReference type="eggNOG" id="COG3703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LLWYTDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="PTHR12192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="210" mass="23103" checksum="22FD63EF5ADC4363" modified="2004-10-25" version="1">MSRPAPARRAYPPSLGEARYLSDAELAASLGATLERWDRTSDLWLFGYGSLIWNPGMPAVEALRAKVHGYHRGLYLWSRVNRGTPEQPGLVLALDRGGSCTGLAFRLAGRTAMPHLEALWRREMAMGSYRPAWLPCALAGGERVNALAFVMRRDVPTYTGKLTDDVVKAVFGCASGRYGTTLDYVSRTVEALRDSGMPDRALEALLARCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XH1</accession>
    <name>Q63XH1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936276.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107194.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0568"/>
    <dbReference type="EnsemblBacteria" id="CAH34558">
        <property type="protein sequence ID" value="CAH34558"/>
        <property type="gene ID" value="BPSL0568"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0568"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1082"/>
    <dbReference type="eggNOG" id="ENOG50331Q5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="193" mass="21135" checksum="63D074CC2AEED3C2" modified="2004-10-25" version="1">MFTNQSNNEVNGGDLVAGDKVDNSTTTVIHVTSNGSASEELSKLYEKLKTDGIGDPSGGKFSEKLEHYMSSATDGDVRGLEKKLCESGRQDILHAALSLKERAAKSIMKHQTSRTAQRIFTIVLTELHARFTLTVTPVIQQGLDRVAVDQCINTIIQGTQNVLGENVLELDAIDLLALLYYLGGNCHIRWDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU5</accession>
    <name>Q63XU5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">grxC</name>
        <name evidence="5" type="ordered locus">BPSL0445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200200.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107070.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0445"/>
    <dbReference type="EnsemblBacteria" id="CAH34433">
        <property type="protein sequence ID" value="CAH34433"/>
        <property type="gene ID" value="BPSL0445"/>
    </dbReference>
    <dbReference type="GeneID" id="56594474"/>
    <dbReference type="KEGG" id="bps:BPSL0445"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1213"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LLWWKGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03418">
        <property type="entry name" value="GRX_GRXb_1_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011900">
        <property type="entry name" value="GRX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02181">
        <property type="entry name" value="GRX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9877" checksum="4243DBA2E1D12213" modified="2004-10-25" version="1">MNKVVMYSTQVCPYCMQAERLLKLRGVEHIEKVLIDKEPERRAEMMERTGRRTVPQIYIGDTHVGGYDDLSKLDREGGLKPLLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XX4</accession>
    <name>Q63XX4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526002.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107041.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0416"/>
    <dbReference type="EnsemblBacteria" id="CAH34404">
        <property type="protein sequence ID" value="CAH34404"/>
        <property type="gene ID" value="BPSL0416"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0416"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1247"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VCGMGPP"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266415" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="33"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="627" mass="65082" checksum="2FB9B7BDDF2D05D4" modified="2004-10-25" version="1">MTDRIRPRPFRSRAGAIAAAFFAVAAAGCANAPGPGAQNAAAPASAASTPPAAPSAEAPAAPAELSSWVDKPGWTAQRDMIAAAHPLAAQAGQAMLKAGGTAVDAAIAAQMVLMLVEPQASGIGGGAFLLHANGKTIEAYDGRETAPAAATDRLFLDANGKPLPRAALGARTVGAPGALRMLELAHRAHGKLPWRRLFQPAIRLAEQGFPLGPRLAAALANEPSLARDPAARAYFYDRNGAPKPAGTTLKNPQLAATLRLVAAHGANAFYTGAIARDIVATVRQAPNPGVLSMQDLAQYRAKTREPLCADYRKWTVCGMPPPSAGGLVVAQILGLLEAQPDWRQIGAQKPVRNAVGVEPTPFAAHLFSEAGRLAYADRAQYVADPDFVAPPGGSWKRLVERRYVAERARLIGDASAGEASAGSPSGLPPATAADRGAEPPSGSQITVVDRYGNAVSMASTLDERFGSRLMVRGFLLNSQLLDFSPASAEHGKPVANRVQPGKRARSTLAPELVFEKGSSRLMMALGSAGGASTANDVAKTLVGMIDWGMTMQQAIALPNFGSRNGPTELEQGRVSDALAGALKARGHDVRVVELGSSLQGIQRINVEGQSVWFGGSDPRRDGIVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y37</accession>
    <name>Q63Y37_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbp</name>
        <name evidence="7" type="ordered locus">BPSL0352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522973.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106978.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0352"/>
    <dbReference type="EnsemblBacteria" id="CAH34340">
        <property type="protein sequence ID" value="CAH34340"/>
        <property type="gene ID" value="BPSL0352"/>
    </dbReference>
    <dbReference type="GeneID" id="56527404"/>
    <dbReference type="KEGG" id="bps:BPSL0352"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1324"/>
    <dbReference type="eggNOG" id="COG1613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TMNMATD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266421" evidence="6">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="36545" checksum="5A22F68BE4D32A31" modified="2004-10-25" version="1">MKHNKGIGRRLAAGVAAALLATAAHADTALLNVSYDVTRELYKDINASFVAAYKQKTGETVSVRQSHGASSAQALSVLQGLQADVVTMNQPNDIDLLAERGQLLPKNWRTRLPNGSSPYSTTMVFLVRHGNPKQIKDWSDLAKPGVQVIIANPKTSGNGRYAYLAAWGYQKLKGATDQQALDFEKAIFRNVPVLDSGGRGATTTFTQRGIGDVLVTFENEVALIDSGAAGASFDAVYPSASILAEPPVAIVDKVVDKKGTRRAAQAYLDYLYSPAAQEIVAQHHLRPRDPNVLKQHASEFKPLKTFTVEQIFGNWANAQKTHFADGGTFDKIIVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YH1</accession>
    <name>Q63YH1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534144.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106844.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34203">
        <property type="protein sequence ID" value="CAH34203"/>
        <property type="gene ID" value="BPSL0215"/>
    </dbReference>
    <dbReference type="GeneID" id="56594437"/>
    <dbReference type="KEGG" id="bps:BPSL0215"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1500"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSMINRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="28"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="347" mass="38230" checksum="F4CFAB51F47CFB73" modified="2004-10-25" version="1">MAYEAASERYADMQYRVSGKSGLKLPALSLGLWHNFGDTTPISTQREILRTAFDLGITHFDLANNYGPPYGSAETNFGRLLREDFKPYRDELLISTKAGWDMWPGPYGSGGGSRKYVLASLDQSLRRMGLDYVDIFYSHRFDAHTPLEETASALASAVQQGKALYVGVSSYSAASTREIAKLLAEYKVPLLIHQPAYNMLNRWIERELLDALDETGSGCIAFTPLAQGLLTSKYLNGVPADARINKPGGGSLKEAHLSAENLEHVRKLNEIAQRRGQSLAQMALAWVLRDSRVTSALIGASRAEQVRENVAALAHLAFSDDEIAEIDRYATEGGINLWEKPSTDQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YP3</accession>
    <name>Q63YP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204752.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106772.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0144"/>
    <dbReference type="DNASU" id="3091931"/>
    <dbReference type="EnsemblBacteria" id="CAH34131">
        <property type="protein sequence ID" value="CAH34131"/>
        <property type="gene ID" value="BPSL0144"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0144"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1577"/>
    <dbReference type="eggNOG" id="COG3500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIDEQAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="40532" checksum="EB55F32BF77650E3" modified="2004-10-25" version="1">MTTSTNERTTRAELQDAPRVARLHPQPDYRISVGGRDLSRLFAPRLVSLSISESRSDEADTIDIVLDDSKNDLDIPKRGATIKASIGWAGEPLVDKGSFVVNEVEHSGAPDIITIRARSAAMTSGMQERREKSWHRQTIGSIVHAIAGRYSLSPTVGDALAKILIAHIDQTHESDMSFLTRLAKRYDAVMNVKDLRLLFMPIGTGQTATGKKLDVLELTRASGDSHRYHVSERENYAAVRAHYHSTGRAKRKSVIVGGENNKNVKVLPEDYATEAEARAAAQAEFKRMQRSQATMSYTLARGRAELFPEMPVTVSGFKPEIDETPWLVKKATHTIGDVGFTTALELEMRDDPTTERHRSHFQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z06</accession>
    <name>Q63Z06_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199880.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106659.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0034"/>
    <dbReference type="EnsemblBacteria" id="CAH34017">
        <property type="protein sequence ID" value="CAH34017"/>
        <property type="gene ID" value="BPSL0034"/>
    </dbReference>
    <dbReference type="GeneID" id="56594120"/>
    <dbReference type="KEGG" id="bps:BPSL0034"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1712"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVMFFED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="51"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="291" mass="31230" checksum="975A2ACB7F049226" modified="2004-10-25" version="1">MTATDRNDNGQAAHWNGRAGRAWADAQPMLDRMFEPFAQRLVEAARTGRRVLDVGCGAGATTLAVAQRLGARGRCVGVDVSRPLIAAARARAERGGVPASFVHADAQTHAFVPASFDTIISRFGVMFFENAVDAFANLLRAATSDASLAFVAWRTAAENPFMTTAERAAAPLVPNLPARQPDAPGQFFFGDARRIETVLAQSGWCGIDVRPIDVECTLPERELIGHFSRLGPLGQLFGDLDDATRARVVDTVRAAFAPYVHGAEVRFTAACWLVGARAPAKWSKRKEAAGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q939D2</accession>
    <accession>Q63R09</accession>
    <name>KATG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catalase-peroxidase</fullName>
            <shortName evidence="1">CP</shortName>
            <ecNumber evidence="1">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">katG</name>
        <name type="ordered locus">BPSL2865</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Gene" volume="296" first="161" last="169">
            <title>The Burkholderia pseudomallei oxyR gene: expression analysis and mutant characterization.</title>
            <authorList>
                <person name="Loprasert S."/>
                <person name="Sallabhan R."/>
                <person name="Whangsuk W."/>
                <person name="Mongkolsuk S."/>
            </authorList>
            <dbReference type="PubMed" id="12383513"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(02)00854-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="35687" last="35692">
            <title>Characterization of the catalase-peroxidase KatG from Burkholderia pseudomallei by mass spectrometry.</title>
            <authorList>
                <person name="Donald L.J."/>
                <person name="Krokhin O.V."/>
                <person name="Duckworth H.W."/>
                <person name="Wiseman B."/>
                <person name="Deemagarn T."/>
                <person name="Singh R."/>
                <person name="Switala J."/>
                <person name="Carpena X."/>
                <person name="Fita I."/>
                <person name="Loewen P.C."/>
            </authorList>
            <dbReference type="PubMed" id="12832453"/>
            <dbReference type="DOI" id="10.1074/jbc.M304053200"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 2-5</scope>
        <scope>COVALENT BOND</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="43098" last="43106">
            <title>Catalase-peroxidases (KatG) exhibit NADH oxidase activity.</title>
            <authorList>
                <person name="Singh R."/>
                <person name="Wiseman B."/>
                <person name="Deemagarn T."/>
                <person name="Donald L.J."/>
                <person name="Duckworth H.W."/>
                <person name="Carpena X."/>
                <person name="Fita I."/>
                <person name="Loewen P.C."/>
            </authorList>
            <dbReference type="PubMed" id="15280362"/>
            <dbReference type="DOI" id="10.1074/jbc.M406374200"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Biochemistry" volume="46" first="1183" last="1193">
            <title>Redox intermediates in the catalase cycle of catalase-peroxidases from Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis.</title>
            <authorList>
                <person name="Jakopitsch C."/>
                <person name="Vlasits J."/>
                <person name="Wiseman B."/>
                <person name="Loewen P.C."/>
                <person name="Obinger C."/>
            </authorList>
            <dbReference type="PubMed" id="17260948"/>
            <dbReference type="DOI" id="10.1021/bi062266+"/>
        </citation>
        <scope>CATALYTIC MECHANISM</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Arch. Biochem. Biophys." volume="471" first="207" last="214">
            <title>Comparative study of catalase-peroxidases (KatGs).</title>
            <authorList>
                <person name="Singh R."/>
                <person name="Wiseman B."/>
                <person name="Deemagarn T."/>
                <person name="Jha V."/>
                <person name="Switala J."/>
                <person name="Loewen P.C."/>
            </authorList>
            <dbReference type="PubMed" id="18178143"/>
            <dbReference type="DOI" id="10.1016/j.abb.2007.12.008"/>
        </citation>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="J. Mol. Biol." volume="327" first="475" last="489">
            <title>Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution.</title>
            <authorList>
                <person name="Carpena X."/>
                <person name="Loprasert S."/>
                <person name="Mongkolsuk S."/>
                <person name="Switala J."/>
                <person name="Loewen P.C."/>
                <person name="Fita I."/>
            </authorList>
            <dbReference type="PubMed" id="12628252"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(03)00122-0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 15-728 IN COMPLEX WITH HEME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2005" name="J. Mol. Biol." volume="345" first="21" last="28">
            <title>Structural characterization of the Ser324Thr variant of the catalase-peroxidase (KatG) from Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Deemagarn T."/>
                <person name="Carpena X."/>
                <person name="Singh R."/>
                <person name="Wiseman B."/>
                <person name="Fita I."/>
                <person name="Loewen P.C."/>
            </authorList>
            <dbReference type="PubMed" id="15567407"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2004.10.020"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF MUTANT THR-304 IN COMPLEX WITH HEME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="EMBO Rep." volume="6" first="1156" last="1162">
            <title>A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases.</title>
            <authorList>
                <person name="Carpena X."/>
                <person name="Wiseman B."/>
                <person name="Deemagarn T."/>
                <person name="Singh R."/>
                <person name="Switala J."/>
                <person name="Ivancich A."/>
                <person name="Fita I."/>
                <person name="Loewen P.C."/>
            </authorList>
            <dbReference type="PubMed" id="16211084"/>
            <dbReference type="DOI" id="10.1038/sj.embor.7400550"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH HEME</scope>
        <scope>SUBUNIT</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Also displays NADH oxidase, isoniazid hydrazine lyase and isonicotinoyl-NAD synthase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text>Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6 7">56 mM for H(2)O(2) for the catalase reaction (at pH 5.5-6.0)</KM>
            <KM evidence="6 7">4.5 mM for H(2)O(2) for the catalase reaction (at pH 7.0)</KM>
            <KM evidence="6 7">700 uM for H(2)O(2) for the peroxidase reaction</KM>
            <KM evidence="6 7">300 uM for ABTS for the peroxidase reaction</KM>
            <KM evidence="6 7">12.5 uM for NADH for the oxidase reaction</KM>
            <Vmax evidence="6 7">11900.0 umol/min/mg enzyme for H(2)O(2) for the catalase reaction (at pH 5.5-6.0)</Vmax>
            <Vmax evidence="6 7">4300.0 umol/min/mg enzyme for H(2)O(2) for the catalase reaction (at pH 7.0)</Vmax>
            <Vmax evidence="6 7">6.0 umol/min/mg enzyme for ABTS for the peroxidase reaction</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="6 7">Optimum pH is 4.5 for the peroxidase reaction, 6.0 for the catalase reaction, and 8.75 for the NADH oxidase reaction.</text>
        </phDependence>
    </comment>
    <comment type="subunit">
        <text evidence="2 5 6">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAK72466" version="3"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAH36875" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AY040244">
        <property type="protein sequence ID" value="AAK72466.3"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36875.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522123.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109459.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="5L02">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5L05">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=15-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SW4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=15-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SW5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A/B=15-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SW6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=15-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SX0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=15-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SX1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SX2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SX3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SX6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SX7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SXQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SXR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.69 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SXS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SXT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=1-728"/>
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    <dbReference type="PDB" id="5SXW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SXX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=1-728"/>
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    <dbReference type="PDB" id="5SYH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.65 A"/>
        <property type="chains" value="A/B=15-728"/>
    </dbReference>
    <dbReference type="PDB" id="5SYI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=15-728"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B=1-728"/>
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        <property type="chains" value="A/B=1-728"/>
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    <dbReference type="PDB" id="5SYV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.75 A"/>
        <property type="chains" value="A/B=1-728"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.77 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="6CFQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.72 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="6MPY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="6MQ0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDB" id="6MQ1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=1-728"/>
    </dbReference>
    <dbReference type="PDBsum" id="5L02"/>
    <dbReference type="PDBsum" id="5L05"/>
    <dbReference type="PDBsum" id="5SW4"/>
    <dbReference type="PDBsum" id="5SW5"/>
    <dbReference type="PDBsum" id="5SW6"/>
    <dbReference type="PDBsum" id="5SX0"/>
    <dbReference type="PDBsum" id="5SX1"/>
    <dbReference type="PDBsum" id="5SX2"/>
    <dbReference type="PDBsum" id="5SX3"/>
    <dbReference type="PDBsum" id="5SX6"/>
    <dbReference type="PDBsum" id="5SX7"/>
    <dbReference type="PDBsum" id="5SXQ"/>
    <dbReference type="PDBsum" id="5SXR"/>
    <dbReference type="PDBsum" id="5SXS"/>
    <dbReference type="PDBsum" id="5SXT"/>
    <dbReference type="PDBsum" id="5SXW"/>
    <dbReference type="PDBsum" id="5SXX"/>
    <dbReference type="PDBsum" id="5SYH"/>
    <dbReference type="PDBsum" id="5SYI"/>
    <dbReference type="PDBsum" id="5SYK"/>
    <dbReference type="PDBsum" id="5SYL"/>
    <dbReference type="PDBsum" id="5SYV"/>
    <dbReference type="PDBsum" id="5SYX"/>
    <dbReference type="PDBsum" id="6CFQ"/>
    <dbReference type="PDBsum" id="6MPY"/>
    <dbReference type="PDBsum" id="6MQ0"/>
    <dbReference type="PDBsum" id="6MQ1"/>
    <dbReference type="AlphaFoldDB" id="Q939D2"/>
    <dbReference type="SMR" id="Q939D2"/>
    <dbReference type="STRING" id="272560.BPSL2865"/>
    <dbReference type="DrugBank" id="DB08638">
        <property type="generic name" value="1-hydroperoxy-L-tryptophan"/>
    </dbReference>
    <dbReference type="PeroxiBase" id="2303">
        <property type="entry name" value="BpCP01_K96243"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36875">
        <property type="protein sequence ID" value="CAH36875"/>
        <property type="gene ID" value="BPSL2865"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2865"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2433"/>
    <dbReference type="eggNOG" id="COG0376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MILAGNC"/>
    <dbReference type="BRENDA" id="1.11.1.21">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q939D2"/>
    <dbReference type="EvolutionaryTrace" id="Q939D2"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
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<entry dataset="Swiss-Prot" created="2003-02-28" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q93UJ2</accession>
    <accession>Q63R78</accession>
    <name>GMHA_BURPS</name>
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        <recommendedName>
            <fullName>Phosphoheptose isomerase</fullName>
            <ecNumber>5.3.1.28</ecNumber>
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        <alternativeName>
            <fullName>Sedoheptulose 7-phosphate isomerase</fullName>
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    <gene>
        <name type="primary">gmhA</name>
        <name type="ordered locus">BPSL2795</name>
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        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Infect. Immun." volume="69" first="34" last="44">
            <title>Detection of bacterial virulence genes by subtractive hybridization: identification of capsular polysaccharide of Burkholderia pseudomallei as a major virulence determinant.</title>
            <authorList>
                <person name="Reckseidler S.L."/>
                <person name="DeShazer D."/>
                <person name="Sokol P.A."/>
                <person name="Woods D.E."/>
            </authorList>
            <dbReference type="PubMed" id="11119486"/>
            <dbReference type="DOI" id="10.1128/IAI.69.1.34-44.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
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            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Microbiology" volume="148" first="1979" last="1989">
            <title>Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.</title>
            <authorList>
                <person name="Valvano M.A."/>
                <person name="Messner P."/>
                <person name="Kosma P."/>
            </authorList>
            <dbReference type="PubMed" id="12101286"/>
        </citation>
        <scope>BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="J. Mol. Biol." volume="400" first="379" last="392">
            <title>The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site.</title>
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                <person name="Harmer N.J."/>
            </authorList>
            <dbReference type="PubMed" id="20447408"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2010.04.058"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH ZINC AND D-GLYCERO-ALPHA-D-MANNO-HEPTOSE 7-PHOSPHATE</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>SUBUNIT</scope>
        <scope>REACTION MECHANISM</scope>
        <scope>MUTAGENESIS OF ASP-61; HIS-64; GLU-68; ASP-98; THR-124 AND GLN-175</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text>Capsule biogenesis; capsule polysaccharide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <proteinExistence type="inferred from homology"/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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    <accession>Q63HZ6</accession>
    <name>Q63HZ6_BURPS</name>
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        <recommendedName>
            <fullName evidence="6 9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="4 9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
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        <name evidence="12" type="primary">bkdA1</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
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                <person name="Thomson N.R."/>
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                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
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                <person name="Brown N.F."/>
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                <person name="Holroyd S."/>
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                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10489"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="4 9"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523292.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112276.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63HZ6"/>
    <dbReference type="STRING" id="272560.BPSS2273"/>
    <dbReference type="EnsemblBacteria" id="CAH39759">
        <property type="protein sequence ID" value="CAH39759"/>
        <property type="gene ID" value="BPSS2273"/>
    </dbReference>
    <dbReference type="GeneID" id="56531636"/>
    <dbReference type="KEGG" id="bps:BPSS2273"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5883"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034616">
        <property type="entry name" value="BCKDH_E1-a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022593">
        <property type="entry name" value="Oxoisoval_DH_suAlpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="PTHR43380:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12573">
        <property type="entry name" value="OxoDH_E1alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="OxoDH_E1alpha_N" evidence="11">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="E1_dh" evidence="10">
        <location>
            <begin position="82"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="45416" checksum="99C9C7DD52E88CC2" modified="2004-10-25" version="1">MSQYGPLRLHVPEPTGRPGCKTDFSYLRLSPAGKVRKPPIDVAPADTSDLAYGLVRVLDEHGRAVGPWAPDLDPDILRKGIRAMLKTRIFDARMQIAQRQKKISFYMQCLGEEAIAVAHTLALERGDMCFPTYRQQGILMVREYPLVDMMCQLMSNERDPLKGRQLPVMYSTRDAGFFSISGNLATQFIQAVGWAMASAIKGDTRIASAWIGDGATAEADFHTALTFAHVYRAPVILNVVNNQWAISTFQAIAGGEGATFAGRGVGCGIASLRVDGNDFLAVYAASRWAAERARRNLGPTLIEWVTYRAGPHSTSDDPTKYRPGDDWTNFPLGDPLERLKRHMIGIGVWSEQDHEDTKAALEAEVLAAQKEAERYGTLADEHVPNVASIFEDVYKEMPAHLRRQRQQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I36</accession>
    <name>Q63I36_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS2233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004548517.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112236.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2233"/>
    <dbReference type="EnsemblBacteria" id="CAH39719">
        <property type="protein sequence ID" value="CAH39719"/>
        <property type="gene ID" value="BPSS2233"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2233"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5830"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NCRGYLE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="43"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="23757" checksum="E5E41301E746174E" modified="2004-10-25" version="1">MARDARAAHSPRRRRAADDDDAPQTLDACRRCGLWEHATQAVPGAGPPRAAIMLVGEQPGNQEDREGAPFVGPAGRVLERALAAAGLDRASVYVTNAVKHFKWAPRGKRRMHKTPAQQEIDACRYWLERELDALGPRVVVALGAIALKAVLDDRHARLQSAMGVVQSAGGRYVIATYHPSFVLRVPDPDARKRAYAAIVEACRIAHELAQRTDGAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I63</accession>
    <name>Q63I63_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941204.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112209.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2207"/>
    <dbReference type="DNASU" id="3096734"/>
    <dbReference type="EnsemblBacteria" id="CAH39692">
        <property type="protein sequence ID" value="CAH39692"/>
        <property type="gene ID" value="BPSS2207"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2207"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5792"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DICCGVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="33964" checksum="F8AB2FCBA5B9A936" modified="2004-10-25" version="1">MDQSFQVNLNRLRYFHAILEHGSIRAAAERLNTAPSVVSRQLQLLESEIGAPLFERRQHGMIATEAATLLVEYTHACRIGLEQFHESLHGELRGRVEIALTVGYVEDLMDSVITGFLHRHPHVAVELNVRTADGVVDDVLRKRAHIGLTYNPSLPPEIRECLSVEHPTFLAVAPDHPLAKRGEPLELRDAVRYPLALMPAPYYGVGQIVHTVAHAENIPLAPRLVTNSVPAMRRFVRSGNGVAFLTRLLVEDDLERGEIVALRMRNPLFNSPCGKVLVHNERALPRAANEILARIVRDLPSFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I77</accession>
    <name>Q63I77_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112195.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2193"/>
    <dbReference type="EnsemblBacteria" id="CAH39678">
        <property type="protein sequence ID" value="CAH39678"/>
        <property type="gene ID" value="BPSS2193"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2193"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6612"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVSICDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="180" mass="19055" checksum="DAE8CBCF3B43D97F" modified="2004-10-25" version="1">MNRFSLPPRPSRMRGAVAVEFAIVMIPLVLLATGVAEFGRAIYQYEALTKATRDAARYLSTYLPTDPAYPLAQAQCLAVYGSTTCGSTGSELAPGLATSMVVVCDAAHAPDCSDSSDPAQFANVPTYDTNNGSPDPASLAGSMNLVEVKIKGYQYRPIPAFPGLPNLSFGNIVTVMRQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IA2</accession>
    <name>Q63IA2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MoaA/NifB/PqqE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187762.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112170.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2169"/>
    <dbReference type="EnsemblBacteria" id="CAH39653">
        <property type="protein sequence ID" value="CAH39653"/>
        <property type="gene ID" value="BPSS2169"/>
    </dbReference>
    <dbReference type="GeneID" id="56598339"/>
    <dbReference type="KEGG" id="bps:BPSS2169"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5744"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FNTDTPQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="386" mass="43420" checksum="8CFF7538A201C852" modified="2004-10-25" version="1">MSIPLLQQVRVGAYIMRQHLSGNKRYPLALMLEPLFRCNLACNGCGKIDYPDPILNQRLSVEECLQAVDECGAPVVSIAGGEPLLHKEMPEIVKGIMKRKKFVYLCTNALLMEKKMDDYAPSPYFVWSVHLDGDREMHDHSVSQEGVYDKAVAAIREAKRRGFRVNINCTLFNDALPERVAKFFDTLGPIGVDGITVSPGYAYERAPDQQHFLNRDKTKNLFREVFKRGEGGKRWSFSQSSLFLDFLAGNQTYKCTPWGNPARTVFGWQKPCYLVGEGYVKTFKELMESTDWDNYGVGNYEKCADCMVHCGFEATAVMDTIAHPLKALKVSMSGIRTEGAFAPDIPIDNQRPAEYVFSRHVEIKLEEIQRAGKGKLQKAPKPAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IA5</accession>
    <name>Q63IA5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537181.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112167.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2166"/>
    <dbReference type="EnsemblBacteria" id="CAH39650">
        <property type="protein sequence ID" value="CAH39650"/>
        <property type="gene ID" value="BPSS2166"/>
    </dbReference>
    <dbReference type="GeneID" id="56531746"/>
    <dbReference type="KEGG" id="bps:BPSS2166"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5740"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PAVNGEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="522" mass="52399" checksum="832ABF4FF663369D" modified="2004-10-25" version="1">MNLNDQIDTLDSRFDQLIRTVCEVASAARHTAATAAADKTAAQAAFEAAAEKHTQAASMSVEQATLEALAAQAAADKEAADALARQAAAVQAAAEAAAAQAVTDKTAAEALAMQAAAERAAAERAAAQAAADKSAAEALAARAAGDRDAAERASGERSAADAAAAQAAEDKAAAEALAAQAAADRTAAEHAATRAAADKAAAESLVAQAAAERATAEHAVTQAAAERAAAEQAAARAAAEKTAAETLAAQAAAERAAAEHAAEQAAADKAQAQALAQQAAADRAAAEQAAAQAEADRAAAQHAAAQAATDRAAAEARATEQAADAKAAAESLAAQAAADRAAAEQAAAQATADKDAAESLFKQAAAERSAAEAAAARAASYKATAEALAAQAERNRAMIEAEPAAPVATAQTANGTLSLHVARPSQDEISLALGEHSVSLPPHQLSQLIEELAHARASMTIEQPSGLPNGWRFVTTRNPLMAVQKQANGDRLLVARHSGYGWVPFTFSPDVVIQLYMLLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IA6</accession>
    <name>Q63IA6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529382.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112166.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2165"/>
    <dbReference type="EnsemblBacteria" id="CAH39649">
        <property type="protein sequence ID" value="CAH39649"/>
        <property type="gene ID" value="BPSS2165"/>
    </dbReference>
    <dbReference type="GeneID" id="56531747"/>
    <dbReference type="KEGG" id="bps:BPSS2165"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5738"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAYKRSK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017829">
        <property type="entry name" value="Hopanoid-assoc_sugar_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03466">
        <property type="entry name" value="HpnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="36279" checksum="1BBF2EE0EAEAF152" modified="2004-10-25" version="1">MTDTQRDLVLVTGASGFVGSAVARAARRQGYRVRVLVRPTSPRTNVADLDAEIATGDMRDEASMRAALRGVRHLLHVAADYRLWAPDPLEIERANLEGAVATMRAALAEGVERIVYTSSVATLKVTPSGASADESSPLAAGQAIGVYKRSKVLAERAVERMIAEDGLPAVIVNPSTPIGPRDVKPTPTGRIIVEAALGKIPAFVDTGLNLVHVDDVAQGHLLALERGRVGERYILGGENLPLQAMLADIAQSTGRKPPTIALPRWPLYPIALGAEAVAKLTKREPFVTVDGLRMSKNKMYFTSAKAERELGYRARPYREGIRDALDWFRQAGYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ8</accession>
    <name>Q63IJ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524841.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112074.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2071"/>
    <dbReference type="EnsemblBacteria" id="CAH39551">
        <property type="protein sequence ID" value="CAH39551"/>
        <property type="gene ID" value="BPSS2071"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2071"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5616"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPYMQGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266066" evidence="1">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="39"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35565" checksum="B3E6B6C6AF8AB99C" modified="2004-10-25" version="1">MHRFTTKPALTLATAIGLAVMASSALAQNEQPLKFDYIIHSSASNTFWQAVKKGMDEACTQVKAQCQMIFTQTEGSVSEQASNLQAALAGKPDAIATTIVDDKAIEPILKEARNKGVTVLAANVDSSKGAKGSVRQAFIGQGFDAAGYALAQKLAEKFPKSGPVNVLVGISAPGQNWSEQRGAGVMRFMADYKAANPGRKITWKRIDSGTDLAVTAERVGAYLNANPDTTAYFDTGFWHAGVAKALKDRGVPPGKILLGGFDIVPDVLNSMKAGYIQVEVDQQPFLQGYLPVIQANLIKKYKLSAWDVETGKGLLLPEQVDGVIELSKKGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IQ0</accession>
    <name>Q63IQ0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544631.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112022.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2019"/>
    <dbReference type="EnsemblBacteria" id="CAH39497">
        <property type="protein sequence ID" value="CAH39497"/>
        <property type="gene ID" value="BPSS2019"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2019"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5542"/>
    <dbReference type="eggNOG" id="COG3809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KSIWHEL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="12513" checksum="7FD69CF22871D1CB" modified="2004-10-25" version="1">MKCPVCVTPDLLMTERQSIEIDYCPTCRGVWLDRGELDKLIARADDDASERRRDPARDAGRDAPPARDEHDEHGRRRHDARERDASYRSQQGGYRKKKSLFDMFDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IU0</accession>
    <name>Q63IU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111982.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1976"/>
    <dbReference type="EnsemblBacteria" id="CAH39454">
        <property type="protein sequence ID" value="CAH39454"/>
        <property type="gene ID" value="BPSS1976"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1976"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6349"/>
    <dbReference type="eggNOG" id="ENOG5032Z2Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIMIAFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="456" mass="48373" checksum="02720FB2076E539C" modified="2004-10-25" version="1">MPATVRDPTMPARKTRRFDPQFDSPPDHYAPMPRLSKLHGLWAATFVIAVASDVLSGAIRYYTSLAGVAALGYLPKALMVACLGLAIVQRPKASHVLVAAYLAAQTCVSLANGVSLSAVGFWIWTIAPMLFAIAMPPQALDALESPRMLGAFVALALLCIGGVLLNYFVKLPWVGGSVDIGGVSVQLAKSSYVGTSSRLPGFGRSSATTGLMIGLLTTWIFPRLRSRLALAALLALAAAGIWATTNKTTLVALALVVALHCLLRTPSLRTVCIWTSAVTIALPIAGWIVTLASTQDVGSSGSLSSMQDRFINTWPLLIEGLLREHLIWFGIGPGGFGSAVGYYTADFGFNVGYADNMALYTVANFGLIGAALIVAAFARLILALPANDRPVWLMLCFLLVSGVTTDICETIGCLLFLGLTLRSINLHAPRRARVGSARIAFERLRYGAGVIAPNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J39</accession>
    <name>Q63J39_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111883.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1877"/>
    <dbReference type="EnsemblBacteria" id="CAH39355">
        <property type="protein sequence ID" value="CAH39355"/>
        <property type="gene ID" value="BPSS1877"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1877"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5341"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGMVATF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="111" mass="12194" checksum="F3EF29B5D3D43F18" modified="2004-10-25" version="1">MNSSYRVGETVSKIVTFDMNAVRRFAALAGGMNPLHHDEALAETARFGGRIVSGTHYSARMMGMVATFAPFLGERRAALGLEFEFSFRKALAAGDTVTMTWRSLRSSRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J42</accession>
    <name>Q63J42_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative chemotaxis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552066.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111880.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1875"/>
    <dbReference type="EnsemblBacteria" id="CAH39352">
        <property type="protein sequence ID" value="CAH39352"/>
        <property type="gene ID" value="BPSS1875"/>
    </dbReference>
    <dbReference type="GeneID" id="56598285"/>
    <dbReference type="KEGG" id="bps:BPSS1875"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5337"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYDIEQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="284"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="558" mass="60414" checksum="0487317E5BD41DDC" modified="2004-10-25" version="1">MPTVTPRASNETLRKSAAGSRLTLGNRILFSFGVLFVLMLFMAALSYQRLRAINDEAISIERDSLPGVYLASSLRASANESYIVLQRAVFVDAEAEAVQRDLAKVPGLLEEFDKLSSAYQASTFRSDDQERFNAFRAAYERYLPLLNDAVQKARGARPDALAAYARVTPAWEEVIRHANVLVQENRRFADQSATLIRESVHGTEITLAVALGVVLVVALMLGYLLHRAVTVPMARLIDVHDVMRTGNLTQRLNLGRSDEFGTLESGFNRMADELTALVAQAQQSSLQVTTSVAEIAATSREQQATANETAATTTEIGATSREIFATSRDLLRTMNEVSAVAEQSATLAGVGQSGLTRMGETMRSVMDAAGSVNAKLAILNEKAININQVVATITKVADQTNLLSLNAAIEAEKAGEYGRGFAVVATEIRRLADQTAVATYDIEQTVKEIQSAVSAGVMGMDKFSEEVRRGMRDVQQVGGQLSQIIAEVQTLAPRFQMVNEGMQTQASGAEQITQALAQLSEAAQQTAESLRQSSQAIDDLTLVANQLRTGVSRFKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JA8</accession>
    <name>Q63JA8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="15">BCAT</shortName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvE</name>
        <name evidence="16" type="ordered locus">BPSS1810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 15">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529067.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111814.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1810"/>
    <dbReference type="EnsemblBacteria" id="CAH39286">
        <property type="protein sequence ID" value="CAH39286"/>
        <property type="gene ID" value="BPSS1810"/>
    </dbReference>
    <dbReference type="GeneID" id="56529774"/>
    <dbReference type="KEGG" id="bps:BPSS1810"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5253"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRGSEMM"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH39286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="314" mass="34214" checksum="E52D4C66E951E6E1" modified="2004-10-25" version="1">MKSSYVWKNGELVPWEHAQVHVMSHALHYGTSVFEGVRAYEIGEKAAILCGREHFERLLFSCKVARIASPMSVGQWMEATVETLRANGQRSAYIRPLVYRGAGESLGLDARQCPAEALLITTPWGAYLGDEALQQGVDVQVSSWRRNGAGAASTLAKIGGQYVNGQAIVMEAHENGMSEGIALDTNGFVSEGSGENVFLVYKNEIFTPSIGSSILSGITRHCVIRIARDLGYTVTETSIPREMLYLADEIFFTGTAVEICPVRSVDRMPVGSGKRGAVTKAIQDQYFGIVRGTHADKWNWLTPVAVPSRDGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JR5</accession>
    <name>Q63JR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525230.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111657.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1651"/>
    <dbReference type="EnsemblBacteria" id="CAH39125">
        <property type="protein sequence ID" value="CAH39125"/>
        <property type="gene ID" value="BPSS1651"/>
    </dbReference>
    <dbReference type="GeneID" id="56529937"/>
    <dbReference type="KEGG" id="bps:BPSS1651"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5044"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWSKIRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266516" evidence="3">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="49"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="204" mass="21771" checksum="AB079FD679EC0437" modified="2004-10-25" version="1">MSADEIRTRRRKLLAAALGAALAPALPALAATQRAQPLAGQSGYHGGLITPPVPVPDMPLRTADGRATRLRALLAGRVTALQLFYTGCSSTCPIQGAVFHRVQTLLGPHPKPDIQLLSLSISPLEDTPQRMHAWLARFGARPGWIAAAPELKDVDALQAFFGGGRTGLDNHGTQVQMIDRRGALVWRTYELPSPETIAALLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JU2</accession>
    <name>Q63JU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative type III secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525252.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111630.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1622"/>
    <dbReference type="EnsemblBacteria" id="CAH39097">
        <property type="protein sequence ID" value="CAH39097"/>
        <property type="gene ID" value="BPSS1622"/>
    </dbReference>
    <dbReference type="GeneID" id="56529966"/>
    <dbReference type="KEGG" id="bps:BPSS1622"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5008"/>
    <dbReference type="OMA" id="HRNWIDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013394">
        <property type="entry name" value="T3SS_HrpB1/HrpK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09613">
        <property type="entry name" value="HrpB1_HrpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02561">
        <property type="entry name" value="HrpB1_HrpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="193" mass="20017" checksum="165D20576758B105" modified="2004-10-25" version="1">MDESRPTYLRCSHAALNGLIDATNLALGGALDGPAADPYDIGLLIDALRVLAPQLPAADMFDGMLQIALGNWDDAARAFAEISNGTSNAVYGKALLALALQVKRDPEWRLAADEVLAAGGPAQAIALVRALERQHDVLLAKEHAQRTGVWELPASVAAASGDAAGTAGEAPGANPSGGFDPQAAFAHQQYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JV8</accession>
    <name>Q63JV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111614.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1606"/>
    <dbReference type="EnsemblBacteria" id="CAH39081">
        <property type="protein sequence ID" value="CAH39081"/>
        <property type="gene ID" value="BPSS1606"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1606"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5887"/>
    <dbReference type="eggNOG" id="ENOG5032Q94">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TINPQHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="214" mass="22310" checksum="69375D56D9C788E1" modified="2004-10-25" version="1">MASNGGRMRAARVLFSFRQSIHIHSETVMSVNGISNQTLNPAQYQSTTSSSRDQKIEELLHEIEDLLLQDDSGGGDDTNVGGDPTGNTNTPAGGHTHAGNSGPGGHVTAGGKPGEDMRDVKLNTKVGGEALHLKMDSQGNLYNGSGNSVGVIDKDGNVKLNSGATKELERLETGGNPFKYGVANVGKRGAGGNMEFTPDEVTVSAGDIDQKADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JX1</accession>
    <name>Q63JX1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type IV pilus biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilV</name>
        <name evidence="2" type="ordered locus">BPSS1593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111601.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1593"/>
    <dbReference type="EnsemblBacteria" id="CAH39068">
        <property type="protein sequence ID" value="CAH39068"/>
        <property type="gene ID" value="BPSS1593"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1593"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5874"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTSIDMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007001">
        <property type="entry name" value="Shufflon_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04917">
        <property type="entry name" value="Shufflon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shufflon_N" evidence="1">
        <location>
            <begin position="37"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="557" mass="58582" checksum="48DD5EC95ADA9A58" modified="2004-10-25" version="1">MLSRRRARGFALIEMLGALAIAALLLAGIAAMMDSSLDDVRAQQAAQYQAQVTAAATRALKRDYDAWLQRANAQTPVVMTLADLQATNDLPAALQTRNAYGQHTCVLVKRTANGVGLDALVVTTGGEAIGDKELGLVAASAGPGGGSIATSAPALARGAFDAWRMPLGAYLGGSSPTCDPADAAPPNAGHLANEIFFNGPGQQINSDYLYRVGVGGHPEANAMQVPIWLTHTFVEGAADAANCGAAGSYANGKLGADAAGQLLSCRNGVWRGAGGHWKDPVRTADDLPTDASNETGDVRLTLDTFRAFAWTGNAWQALAVDQNGNMIVPGVVSANQYEITGRVVVNTPCAPEPSRPNAGLVSMGQDGQVLSCQGGKWLPQSGIKIGGTETACEILMETPGATDFSCGYTYRGPYPNPPLITYEPDGTYTYTINRPVKLDNNGLIAVSAYMHMSYATCALKGREGQMRLVVDVIDVQSNQVIAHGEAQSTKLIEDAATINVTLNQAAEPRSGYTVRLSSKWATYDSYAGTPWTSSYCSGGKTFLQTPLVTGWTINSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K19</accession>
    <name>Q63K19_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940818.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111553.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1547"/>
    <dbReference type="EnsemblBacteria" id="CAH39020">
        <property type="protein sequence ID" value="CAH39020"/>
        <property type="gene ID" value="BPSS1547"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1547"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4904"/>
    <dbReference type="eggNOG" id="ENOG502ZBVJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFELKWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013387">
        <property type="entry name" value="T3SS_PrgH/EprH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019029">
        <property type="entry name" value="T3SS_PrgH/EprH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09480">
        <property type="entry name" value="PrgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02554">
        <property type="entry name" value="PrgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="428" mass="46348" checksum="5E8BA792FE522A1D" modified="2004-10-25" version="1">MNKPDSGLEALQLRILFGPLFGSDIAILSGEVFFCVGEQVIDDRPAEHPENRAGHLLERAVDTLYIPHRAGAPNFRLRFPGAPTQAARTAETGEAAPGDFEVDFLSADGCVTQRAAFNTVCRFGDLAFALRRQREPWSEAVMHYAPHAPSRAADAAEPGAPGEPGDGGERASRFALKLGALLVAGVALAALAYWQVQRYVGAQKLASVNGVLAGAPVPNAILPGDDGRIYVLSASQDGAEWDREALLKAALPEKIEVAVIGAERQRVERRLDEAGVDFVTVRLDAPEHPELILTGAAPAAARARAIGELRRAAPYVRDVRVIDASLGAIEQEARNALDKVGARYRLLARRGGATFEVASSFGDEELAALQNLMRSFGHKWGTRRVDFKIALRTDWLKGKSYREGGDGYVLLDHASWYFPQPLEGAHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K44</accession>
    <name>Q63K44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204593.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111528.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1522"/>
    <dbReference type="EnsemblBacteria" id="CAH38995">
        <property type="protein sequence ID" value="CAH38995"/>
        <property type="gene ID" value="BPSS1522"/>
    </dbReference>
    <dbReference type="GeneID" id="56597866"/>
    <dbReference type="KEGG" id="bps:BPSS1522"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5777"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DVWVPPD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="223" mass="24253" checksum="31E1982F2581B2DB" modified="2004-10-25" version="1">MVVERKCERVLVVDSHPIVRDGIEVVLGKAYAGIDVDGAADMAEASDRCGRDRPDLVLLDVMLPGEDPLPAMGEILRAHPGLRFVVFTALGSEARAADAIRFGASGYLLKWCSPDGIVQAIRRVMAGRVHIDPSLDEARVASAAGGRTLASPVDELTRREKQVLKLIADGMRNREIASLLNISPKTVDCHRQRLMQKLGARNVATVIHWAYRYGYANACAPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K48</accession>
    <name>Q63K48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004557777.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111524.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1518"/>
    <dbReference type="EnsemblBacteria" id="CAH38991">
        <property type="protein sequence ID" value="CAH38991"/>
        <property type="gene ID" value="BPSS1518"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1518"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="95" mass="10729" checksum="E873B4825E7544FC" modified="2004-10-25" version="1">MKSGVVRRSTCAARLDLRRNCRPYGPVPYGAFDIRKRYALDGATALRDKPGGGEGNRGRALTEQREVDIRALLRGQMPDQLKMSFALWTRHAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K52</accession>
    <name>Q63K52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940791.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111520.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1513"/>
    <dbReference type="EnsemblBacteria" id="CAH38986">
        <property type="protein sequence ID" value="CAH38986"/>
        <property type="gene ID" value="BPSS1513"/>
    </dbReference>
    <dbReference type="GeneID" id="62345148"/>
    <dbReference type="KEGG" id="bps:BPSS1513"/>
    <dbReference type="OMA" id="THAEPRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="11329" checksum="71834F098E709658" modified="2004-10-25" version="1">MPDTSGTQQPRRPHSALHSAKTHAEPRRAVEFTYVHFSVYMFPFRLAMMKHTSNHPDHSSAPPNLEKLENYPDLFARKAIELNGKRSRKMLWILLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KS0</accession>
    <name>Q63KS0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528603.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111301.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1292"/>
    <dbReference type="EnsemblBacteria" id="CAH38762">
        <property type="protein sequence ID" value="CAH38762"/>
        <property type="gene ID" value="BPSS1292"/>
    </dbReference>
    <dbReference type="GeneID" id="56530289"/>
    <dbReference type="KEGG" id="bps:BPSS1292"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4576"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WWVGSRG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="431" mass="42713" checksum="5BE1D6E286B25899" modified="2004-10-25" version="1">MNAPAEPGATTVPHRAGSLTILQGAALYIGAVLGTGVIALPALAAEVAGPASLLAWAALVMLSIPLAATFAALGARYPDAGGVSTYVRKAFGPKAAAVVGWCFYFAVPAGAPAAAMFGGAYVAAVTGGAHATMIASAAVLIALVAAANAFGVTVSGRMQLVLSALLVALLVAAVLASAPHARAANLHPFAPHGWLAVGEAAALLVWSFAGWEAITHLAAEFRRPARDLPRSTGIAVAVVGLLYLSVAAASVLVLGPAAGESGAPLAALIARGIGGNAQLIATAAALLLTLGTMNAYFAGAAKLGAALGRDGALPRWFAQGSQTGGVPRRSLAVIAALAGCALVAAVATGMGPKPLVLATSGNFVMVYVLGAAAATRLLPRGGLAHRASIVALLSALLLLATTGWYLLWPLLLTASAIGYLFITGRRAAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L04</accession>
    <name>Q63L04_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556155.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111217.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1209"/>
    <dbReference type="EnsemblBacteria" id="CAH38676">
        <property type="protein sequence ID" value="CAH38676"/>
        <property type="gene ID" value="BPSS1209"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1209"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4446"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="STVSTRC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="121" mass="13035" checksum="68340301520FBD5C" modified="2004-10-25" version="1">MTKGTRQTHSAAFKAKVALTAVKGERTLAELAQQFDVHPNQITEWKRQLQERAADMFGAGAAPSSNEPPVDLKSLHAKTGQLTLENDFLSGALDKAGLLSAKKCSTVSTRCRLRSRPVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L19</accession>
    <name>Q63L19_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205557.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111202.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1192"/>
    <dbReference type="EnsemblBacteria" id="CAH38659">
        <property type="protein sequence ID" value="CAH38659"/>
        <property type="gene ID" value="BPSS1192"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1192"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4427"/>
    <dbReference type="eggNOG" id="ENOG5034BFQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ENGWLAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="441" mass="46654" checksum="76462580C011FEBE" modified="2004-10-25" version="1">MNDVFGERASDVASGMKGGTKDGIRKGDVKKGDIKGDIDIDIDIDGGAARDDCAIVTCHAPAAILWDAADAAPELVAARPALADALAALRAGMPAAGRIAPFDEPAAVRPYRHLRAFYLRRADGVLAIKGSEIFAADVEPHLRMLGAHRVEFPGRGRSLFSALEHFPLNEQKIPLAMSIDEALDDVQAAAAVQRAHLARFGCIARVPLPLVAIRWPDAAAHAHLARLAPLLTRRARRAVERVAADGLGALAYHYPGVAHRVAHLPQLLAARPENGWLARLSALTDPAATIDGWLELLARLLALGFLPASVESMGVGHCIDTKNAVIDGGFVDLGSVCRAADVTDDRRLLETLLSAIADLAQTCRQFLLGDTPDVEAEYRNPSLAMVMVLNRLLPDLAARVQRLGGADPRVADMLGTRPAAGALAAELTRLGLGAAPPGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L46</accession>
    <name>Q63L46_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537324.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111175.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1162"/>
    <dbReference type="EnsemblBacteria" id="CAH38630">
        <property type="protein sequence ID" value="CAH38630"/>
        <property type="gene ID" value="BPSS1162"/>
    </dbReference>
    <dbReference type="GeneID" id="56530424"/>
    <dbReference type="KEGG" id="bps:BPSS1162"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4390"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFDKSMD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="136" mass="14203" checksum="EE578290AE42474D" modified="2004-10-25" version="1">MDAREPIPSLKVFLVDYAAPVRNRLTSLLETIRGVEVVGEAEDVPAALAGILETGADVAVIELRLTGGSGLELISALTRAAPRVVKIVLTNLSGAAFRAACSDAGADFFFDKTADVDAACRTVRTLAGAHRPRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L59</accession>
    <name>Q63L59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111162.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1149"/>
    <dbReference type="EnsemblBacteria" id="CAH38617">
        <property type="protein sequence ID" value="CAH38617"/>
        <property type="gene ID" value="BPSS1149"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1149"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5309"/>
    <dbReference type="eggNOG" id="ENOG50316RI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRYSERV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="18467" checksum="74A4AF1E68CBA09D" modified="2004-10-25" version="1">MAQPLAPIAARLAPDARMFDMRVALLAHDYARRAPRDVMGAQGLVIVGVGKSGERGFQMLYRFSDACTRLEALGTNVIFVYPKESARHVLDPISVSSAQIRQRPCLFLDDEGRFFQRPCPPRSLSLVHLSRDMKPLDTAKIVLHDHAWDGELLAFFARAQARVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LR1</accession>
    <name>Q63LR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dipeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524048.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110960.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0952"/>
    <dbReference type="EnsemblBacteria" id="CAH38414">
        <property type="protein sequence ID" value="CAH38414"/>
        <property type="gene ID" value="BPSS0952"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0952"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7263"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FIRSVYI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="111"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="32875" checksum="E74060A155BCA90A" modified="2004-10-25" version="1">MNASPDHSRPNPAATTLRAWLLSDAPASRRQATLGLAYRRWRRFAGNPLNLLGLAILAALVAIALVAPFVMPHDPLRQVLADRLLPPGSPSHWLGTDQLGRDILSRLIAGSRLTLGIAILVVAIVVPIGLAIGTTAGYCGGLVDSALMRITDVALAFPKIVLALAFAAALGPGVVNAVVAISITAWPAYARLARAETLRIANADFIHAARLQGASDLRIVLRYVMPLCLSSVIVRATLDMAGIILTVAGLGFLGLGAQPPSPEWGFMVASGRNVLLDAWWVATLPGAAILVVSIAFNLLGDGLRDVFDPRHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LR5</accession>
    <name>Q63LR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543524.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110956.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0948"/>
    <dbReference type="DNASU" id="3094902"/>
    <dbReference type="EnsemblBacteria" id="CAH38410">
        <property type="protein sequence ID" value="CAH38410"/>
        <property type="gene ID" value="BPSS0948"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0948"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7258"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATHGPKQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="32778" checksum="8473363331133218" modified="2004-10-25" version="1">MRRLPPLNALQIFATVARHRSFTRAADALCVTQGAISRQIQSLEAHYGFALFMRHARGLTLTVEGEQLLPVVVESFARIEDISLKLTRQRTDLALKVPTCVMRWVLPRIMRFQREHPDLHVQMTTTWRHDVDFQSEPFDAAIVYGMSPGPDVAAVPLFDERLTPVCAPDLLEGRPLARVEDLACHTLLHPTRDHRDWRRWLDYAGAAGVDPDRGPSFDSLDLATSAATQGFGVALGDLTLSEEDFAARRLAMPLDIVQRTGARYYFVYPESVAQQQKIQRFSAWLDANRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LT2</accession>
    <name>Q63LT2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphinothricin N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110939.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0930"/>
    <dbReference type="EnsemblBacteria" id="CAH38393">
        <property type="protein sequence ID" value="CAH38393"/>
        <property type="gene ID" value="BPSS0930"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0930"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7229"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EAAGIWT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="188" mass="20264" checksum="0E736BCA41643D75" modified="2004-10-25" version="1">MKATDAPTSSAIVRDATEHDLEAIQAIYAHHVLTGVASFEETPPSVDDLRARREAVRRHGLPYLVAELDGVVAGYAYATPYRPRSAYRYAIEDSIYVNEACRGRGIGRVLLAALIARCEAGPWRQMIAVIADGGRGGSTSLHRALGFEPIGTLRGVGFKHGRWIDTALMQRVLGDGAQTPPSNADASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ1</accession>
    <name>Q63MJ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553266.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110680.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0665"/>
    <dbReference type="EnsemblBacteria" id="CAH38124">
        <property type="protein sequence ID" value="CAH38124"/>
        <property type="gene ID" value="BPSS0665"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0665"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FVDAYPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="298" mass="33567" checksum="718DEFA797D6C5B1" modified="2004-10-25" version="1">MNDTVRRRRSEALSIRPLSGHIGAEVQGIQLGSQMAPNDIRFITQALLTHRVIFFRRQHHLDDLAQELFAQAFGEIVKHPTMGGKTGSAILELHSHEGGRANSWHTDVTFGLRPPKLSVLRALALPDAGGDTVWANTVAAYQHLPSSLQDLVDKLWAVHGNDFDYAASRVELLHDPVAKEYRKKYAAQVIKTEHPVVQIHPETGEKSLLLGHYAQRFVQYDTHDSNRLYEILQAHITRLENTVRWHWAAGDVAIWDNRSTQHYAINDYGDATRVMRRVTVIGDIPVAVDGRKSIPHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY2</accession>
    <name>Q63MY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202234.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110537.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0516"/>
    <dbReference type="EnsemblBacteria" id="CAH37973">
        <property type="protein sequence ID" value="CAH37973"/>
        <property type="gene ID" value="BPSS0516"/>
    </dbReference>
    <dbReference type="GeneID" id="56531035"/>
    <dbReference type="KEGG" id="bps:BPSS0516"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6676"/>
    <dbReference type="eggNOG" id="COG3516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMVMGDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008312">
        <property type="entry name" value="T6SS_TssB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35850">
        <property type="entry name" value="PTHR35850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05591">
        <property type="entry name" value="T6SS_VipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028301">
        <property type="entry name" value="UCP028301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03358">
        <property type="entry name" value="VI_chp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="182" mass="20120" checksum="5F65621FF49D46ED" modified="2004-10-25" version="1">MVRQKDGQKFIGESRAPRVQIEYDVEVYGSQKKVELPFVAGVMADLSGDNVEPLGPVEDRRFQEIDVENFDERMAQIAPSLSYHVKNVLTNDGTLIPIDLTFTSMESFEPADVVKRIPELSTLLEARNRLKELLTYMDGKAAAEDVIQELLKSPQWANEADAAEQSGGAGEGGDHQPEEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N70</accession>
    <name>Q63N70_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative heptosyltransferase (O-antigen related)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536857.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110449.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0425"/>
    <dbReference type="EnsemblBacteria" id="CAH37881">
        <property type="protein sequence ID" value="CAH37881"/>
        <property type="gene ID" value="BPSS0425"/>
    </dbReference>
    <dbReference type="GeneID" id="56531125"/>
    <dbReference type="KEGG" id="bps:BPSS0425"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VLTSFHQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="418" mass="45211" checksum="4A04AD7592A9ADB7" modified="2004-10-25" version="1">MADERAAKRWPARGEDMKILFIKLSALGDVLASTPLFASTKAEHPDWFVGHVVARPYAAATRNNAHVDAQFIVDSPLSGGAIRKIRVAARIWRYMMRERYDIAVVLHRSFVLQLICRLASVRKTIGYESRFSFILSHSIPFSMQGNRSGLELRLLKSAGIIHDEKKKLRFDIDFGNVDRNRLRALPAAFIAVNAGGGNADAQAANKLWPAERYGALIKRLPLPVVMLGHGAADEDIRDRVAATGARFVDMVGKTNLDETAVILERSRLYVGNDSALLYLAASLGVTTIGIYGPTDPAAFSPLGANNLWLSGKTSCAPCYSSFDGIGGRMYTCTNNICMQAVTVESVSERIHAALHQDQNLQAAGPDVVGSGQGRAASETRARADTDARADHQALGDGGFAVPLSHRSATGARVPGRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NA5</accession>
    <name>Q63NA5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="journal article" date="2018" name="J. Biol. Chem." volume="293" first="19429" last="19440">
            <title>The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA.</title>
            <authorList>
                <person name="Winter A.J."/>
                <person name="Williams C."/>
                <person name="Isupov M.N."/>
                <person name="Crocker H."/>
                <person name="Gromova M."/>
                <person name="Marsh P."/>
                <person name="Wilkinson O.J."/>
                <person name="Dillingham M.S."/>
                <person name="Harmer N.J."/>
                <person name="Titball R.W."/>
                <person name="Crump M.P."/>
            </authorList>
            <dbReference type="PubMed" id="30337369"/>
            <dbReference type="DOI" id="10.1074/jbc.RA118.005173"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 1-85</scope>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552310.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110414.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="6G1C">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.56 A"/>
        <property type="chains" value="A/B/C/V=1-85"/>
    </dbReference>
    <dbReference type="PDB" id="6G1N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B/C/D=1-134"/>
    </dbReference>
    <dbReference type="PDB" id="6G26">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.49 A"/>
        <property type="chains" value="A/B/C/D=1-137"/>
    </dbReference>
    <dbReference type="PDBsum" id="6G1C"/>
    <dbReference type="PDBsum" id="6G1N"/>
    <dbReference type="PDBsum" id="6G26"/>
    <dbReference type="SASBDB" id="Q63NA5"/>
    <dbReference type="SMR" id="Q63NA5"/>
    <dbReference type="STRING" id="272560.BPSS0391"/>
    <dbReference type="EnsemblBacteria" id="CAH37842">
        <property type="protein sequence ID" value="CAH37842"/>
        <property type="gene ID" value="BPSS0391"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0391"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6519"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QWLLVDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="6G1C"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6G1N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6G26"/>
        </source>
    </evidence>
    <sequence length="138" mass="15120" checksum="0075F2CF298A179D" modified="2004-10-25" version="1">MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGEDVEFTCSTVEELVAKPEYAGAVWALVSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ND9</accession>
    <name>Q63ND9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529892.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110380.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0360"/>
    <dbReference type="EnsemblBacteria" id="CAH37808">
        <property type="protein sequence ID" value="CAH37808"/>
        <property type="gene ID" value="BPSS0360"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0360"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6483"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NKRVWCR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="466" mass="51832" checksum="FFCAD1CBC3F698F7" modified="2004-10-25" version="1">MSAVVGCRRTSLVAQAGHWMQRHGALIRGIQWVVVLVYAFLILVPAFTPLPDDTAHLWSNLTLAAQFVFWGIWWPFVLLSMVMLGRVWCGVLCPEGALSEFASKFGRGRAIPRWMRWGGWPFVAFGLTTIYGQMVSVYQYPRAVLLVLGGSTLAAIVIGFLYGREKRVWCRYLCPVNGVFSLLARLSPLRYKVDEDAWRRSYRKGEDGHRVIPINCAPLVPLRNMKGAAACHMCGRCSGHRGAIELTARSPSEEVVALGDRQASSWDTALILYGLLGIAIGAFHWTVSPWFVQIKQTLAGWLIDHDIMWPLDTNAPWFIFTHYPEHNDVFSWLDGSLVVAYIVGTGLVYGTALAVLLAGAAAMLGRFERVRLHHLAQALIPLAGAGVFLGLSATTLSLLRAEHVPLGWASDVRIAILVGANLWSAWLAWLVTGRYASWPRRLLAMLWFGAALAVVDSAWWLMFWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NI8</accession>
    <name>Q63NI8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative multifunctional polyketide-peptide syntase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110331.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0311"/>
    <dbReference type="ESTHER" id="burma-q62b79">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37759">
        <property type="protein sequence ID" value="CAH37759"/>
        <property type="gene ID" value="BPSS0311"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0311"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4296"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIGHANC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="AB_hydrolase"/>
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    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
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    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
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    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
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    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
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    </dbReference>
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        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="816"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1878"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1932"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2662"/>
            <end position="2688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2724"/>
            <end position="2745"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="2842" mass="297487" checksum="B0565F0F92F0A923" modified="2004-10-25" version="1">MVLMRQIVSTSNGSLDSRARIIAFPFAGGSGASYADIARELGDAFAFTTLSLPGRGATQHIPFYDDWPSLVDDLAAEVARLDDGTPFFLFGHSLGALLAYEVARTLEQRGGARPAGVFLSGHPAPSRERAAPAWRRQTHALPDAEFVEAVRRWGFFPEGALDDPDVARYVLPPLRADLRLAETYRHARGDALRAPCAIYGGAADPSTSADDLRAWRAHVSPQHACPVESFDGHHFYFLDPSSRAALCASLAGHIEQRLAQRPASIVAAAPDPGSRVAACLRTAGDWGDAQAVLAAIREHVARTPDALALQDGERTWTYRQLASHAAELADAFRAAGVGRQDVIGVFLPHGAEYVLTIVGAWSIGASVCLLEKSWPDSLVGEFVASCRVAQLATTPALLARAAKHLPDARCTLVGARPPLAQRAWTSVAPRPDDIAFVSLTSGSTGKPKAVLTTHVGTSYCFHARDALYPYADGEREGLNVFLAWECLRPLMFGRPAVVIGDDVIFDPPRLVALLRRERITRLVVTPSLLESVLDFPGIAGQLRDALAHMSAWFLMGEVVPQRVVDKARAAFPPSVRLVNAYSTWESLDVCYADLLPSRASDDGRRVPIGRPLPGCALAVLDEAGRAVPAGETGELYIASPALGPGYLDDAARTAEKFLPSVAALAERGHDAPAYRTGDRARLLPDGQIAILGRIDNTVKIRGFKVLLHAIENVLDAVDGVSKTLVVPIDDPHTKQPSALAAYVVGRGGAPSETTLARLRQQARAKLPEYAVPAHFIGLEAFPLRAGTSRKLDRRALPPPEPPAGASPAERGAVPAAAGDGLEARLAEVWRDVLGVASVARDDNFFELGGNSLSAAKAVGALGERLGLSLAVVDLYQHSRLRDLADYCRRSREEDAARGRADAARDARAARTASGAGAPKVAIVGMAGRFPGADSVDAFWRNLTQGVDSLSRFTREQLLAKGVDAAQLDHPDWVSAAQVVGDADKFDALFFGIGRREAVLMDPQHRLFMEVAWSALEQAGYARAENRYRTRTGVFASCGIDGYLVHHLQGGGLLTPLDPGRLMLTEIGNEKDYVATRVAYQLDLGGPAVSVGAACSSALVAVVQAVQAIRAGQCEMAIAGASALSFPNFGFCYEDGLVGSADGHVRPFDARASGTLFGDAVGAVVLKRLDLAEADGDPILAVISGVGLSNDGRMKAGYTAPNADAQRRCIVDALDMADVRSEQISYVECHATATLIGDAIELKGLSDAFAQTRGADADAAAVAGRCAIGCVKGNIGHANCAAGITGLIKTVLQLRHRQRVPTVHFDTLNPKLVPFVEHDASPFVVQRHADDWTVADPATQLPRRAGVSSFGIGGTNAHVIVEEAPPPARAAAPAESVPRAHHLMTVSARTPGALARNLQALAGRLAALDAADLGCAAHTLHVAREAHPLRVALAVPARPADAAAALRASAAALAEASVDMPDMSDAPAAPVRAKPGATVAFCFSGQGSQHPGMARELYRSNTEAGRFRHHFDAACAALERALGAPIAYAILNADDEAMRRPLVTQCGLFALEHALAAVLGEYGVRPVAVAGHSIGQYAAAVAAEALTLEQAAALVAARAGATEALNAFSAGGGAPARGGMLAVTGDDARIEQWAAGRADVWIAVRNAPRTLVLAGAQPALADAARALAALGCRCRPVPVSHPFHTPLMQPVADAIIAQRIAGAAPRIPMTCNVTGGWLGADAASPGYWARHLLEPVRWSDNVAALLRWQPDVVLEIGPGTVLCSLIGKHLAGGANAGAPARPNGHAGANAAALAPRVLPTLPAAGDDAHDAAHFCNTIGQLWCAGVPIDWRAYHAHEAAAPGRALARVPLPGYAFERDSYWTRPRASIYVDAAQADAEPDAAPAAADHTDAADADSARAALADASDKTPAARAASTHTCSGECACERACAAEPRPSGGVERVTAPPAPSSRGLVRLKPRRRPRMKLYCFPYAGGSSRSFDGWARTAPDWLDIVAIEWAGRNARAEESLARDDAADLAAREAIAAAIVADAGELPVAFCGLSYGGAAATELLGGPLRAWAASGRVKGLAIVGRAPLLEQPAIDAPADSFLLVPDALRDDPLWQEIFRPVLEADLDADARCAHRIAQRWRDGGRQPLLTVPLQIHGAHDDPAFDWRLAGDWARISSAPLASLHRYPGGHDFMIRCEAEIVARVAAWLRPQRAARTAAPAPTFALHWQPRAIAPIAPITPNPLAAADGSSAGASLADASQADTSGAAMGAAPGAAPLPECAVYAAGGEASAFERLAPLLRESGDEAALLCIGAADDPLGAAQCAGFVKLWQALAARECAGTLTLVLPAGAASGPLVGAARVASAEHAALRMRLVLADDHPDLAPRAADPRWAAGLARDAAHCGDEPWLLRRAGRMFAPRLMPHAAPALPEGTLGAAGGPYLVTGAAGGVGRALVDWLIDEQQVPPQRLIALCRNADLAPRGVRAVAADLADARALGAALESIGEVEGIFHLAGVLDDGVIANLDEARLRRVLAPKQSLAALLAHAPRWRTRWAVAFSSTSALLGVPGQANYAAANAWLDQLACWPARAGEPPVLSIQWGSWADVGMSARSDRAQRRAMQDGERALAPDAAFAALGALLAGMLGGAAAARQFAVCDVDWPRSPWRDAPIVEAVARGAPNAGSEAEAAKVASATNRTKRADEASGANGWIAASSTPVAMSSATPAAHVCGNACVDAAAPRAGDESDRARSPRPASEPARFAAPTVEAAAVAQAPAARATRSASAPDPVRAFLEDYVSRWDERLDLATLGLDSLDLAQMRNGFFKKFGVQIPLSTLASPTLKIGELARRMRNVAGIADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NK7</accession>
    <name>Q63NK7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative multidrug efflux system exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203095.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110312.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63NK7"/>
    <dbReference type="STRING" id="272560.BPSS0292"/>
    <dbReference type="EnsemblBacteria" id="CAH37740">
        <property type="protein sequence ID" value="CAH37740"/>
        <property type="gene ID" value="BPSS0292"/>
    </dbReference>
    <dbReference type="GeneID" id="56597820"/>
    <dbReference type="KEGG" id="bps:BPSS0292"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6396"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DNSKMWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="73"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="409" mass="43036" checksum="147F73C3524A69BA" modified="2004-10-25" version="1">MAILRTSRSRIAAAAFAVVFIAGLGTFGAIRVNAGAPEKSAAPLPEVDVATVLSKTITDWQSYSGRLEAVEKVDVRPLVSGTIVSVNFKDGALVKKGDVLFVIDPRPYQAEVDRAAAQLAGAQARNGYAQSDWQRAQRLIGDNAIAKRDYDEKQNAAREASANLKAAEAALETARINLGYTRITAPVSGRVSRAEITLGNVVSAGASAAPLTTLVSVSPIYASFDADEQTYLQYIGGAKDGRKVPVELGLANESGYSRQGVIDSVDNRLDTSSGTIRVRARFDNADGALVPGLYARVKVGGSAPHPALLIDDAAINTDQDKKFVFVVDQQGRVSYREVQLGAQHGNQRVIVGGLAASERIVVNGTQRVRPGEQVKPHLVPMTGGDDAAAATPVAGGVQRPRAAQGNARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NN7</accession>
    <name>Q63NN7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110282.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0263"/>
    <dbReference type="EnsemblBacteria" id="CAH37709">
        <property type="protein sequence ID" value="CAH37709"/>
        <property type="gene ID" value="BPSS0263"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0263"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4229"/>
    <dbReference type="eggNOG" id="ENOG5033D4U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LTWITQD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045629">
        <property type="entry name" value="DUF6232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19744">
        <property type="entry name" value="DUF6232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16275" checksum="0EFFE69896B226CA" modified="2004-10-25" version="1">MRRRVPFTRRSNLLRCAFSIRTHLMENAFNERGVMVTRNGLSAAGQIFALREIRGVEVRTVRKNKLVPCAISLTGAAAAIAGGALGSSALLVAGVMLVVVGYLAWTTQDVTHRLIVDMPDGKREAIMSVDREFVERVAHAVDAARAAGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NS1</accession>
    <name>Q63NS1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110248.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37673">
        <property type="protein sequence ID" value="CAH37673"/>
        <property type="gene ID" value="BPSS0228"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0228"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4186"/>
    <dbReference type="eggNOG" id="ENOG50316NN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PEIIRNH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="10002" checksum="901F22412ED15DA4" modified="2004-10-25" version="1">MSCDKKIVLIRSIPMATLEAFRCVLDDARTPEIIRHHIIDALQYALRNYGQVFTAKEVEWLAAWDDPRIPLAARKELDRREPAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P04</accession>
    <name>Q63P04_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110165.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0144"/>
    <dbReference type="EnsemblBacteria" id="CAH37589">
        <property type="protein sequence ID" value="CAH37589"/>
        <property type="gene ID" value="BPSS0144"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0144"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4074"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWTSSAK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07430">
        <property type="entry name" value="GH15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015220">
        <property type="entry name" value="Glucodextranase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09137">
        <property type="entry name" value="Glucodextran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266496" evidence="3">
        <location>
            <begin position="23"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="4">
        <location>
            <begin position="769"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="871" mass="92339" checksum="F10054986E65E825" modified="2004-10-25" version="1">MLVGSLAALAGAAALPANTSAAAEAFGSPGAAPVRGPAAKSFLGTAVNGASRVYFTGYRGILSEVYYPVLDTPESVDLQFLVGDAGKTFVDEEKQQAYSAAQTDTRTMSWQVTTGNSSHNWQIRKIVFADPNHNAIVQRVTFTALNGRKVGDFNLYMLSKPYLDNAGANNTAQTVSGSGGTALVANHNSRYSALVASRPWKVVNGVGMTSNGFVGQSDGWTDLLGGTADKTMDWTFSSATNGNVAQMGWLDLGDPSATSVSFDVVLGFGGTQDQALGDANTVLGSDLAGEQQQYDTGWHNYAAGLSSQNGAADDGYYLAAMTLKTMQDKSNGAMIAGIGTPWGETQGDANAGGYHLVWPRDLFKFANALTTAGDTSSATSVVNYLFNTLQQTTDCGTAEYNAPGCAQGYSRVGRFPQNAWVNGWPYWQGTQMDEQAMPIILAWRLGPSVFNPLWPKIKLTADYIVNTGPWTYQERWEENAGYSPSTIAAEIAGLVTAADIATQNGDTASAARYLAAADYWQENVAAWTYTSSGAFGNGSYYIRINPAGRAGTGTDRASFAPTAGPDTPQTLSVKNGGGSHDARRVVDGGFFELVRMGVKRATDPTIANTISVYDSVLGQTLNVANAPALSPNAWFRYNFDGYGEHNDGGDFDGTGAGRLWPIFTAERGMVEIARQGSGGAGSAYFSTLKQLTTPEGFVPEQVWSNSTTLPDGWAVTTPAGYTPGQPTKSMAPLNWAMGEYISLLASIQAGRIVDVPSVVCARYNNCAAPPQSGQVPVAVNVNASTQLGQQMYVTGNVAALGNWNTDLGIPVDPASYPVWRNTVNLPAAQAIQYKYYRKNADGSVTWENRSGNRQLQTPASGTLALNDQVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P05</accession>
    <name>Q63P05_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531545.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110164.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0143"/>
    <dbReference type="EnsemblBacteria" id="CAH37588">
        <property type="protein sequence ID" value="CAH37588"/>
        <property type="gene ID" value="BPSS0143"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0143"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6191"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFVLLWN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="416" mass="44165" checksum="41554E8A83D40EF6" modified="2004-10-25" version="1">MRSPHLGQGSNSANVRRYNERLLLKTLRRAGSASKADLARLANLTGTAVGSIIASLAEAKLIEFAGRRAEGQRGQPASLIRLDPRGAFGIGVRLDRMRIETALVNFAGDVIGRRSHDTLLPQPTAVLEIVREDVAAMQQLLCAHERARLTGVGVAQPYNLGSWLREIDLPADAFGAWAEVDFARELDRAIELPVFSENDGNAAAIAELFYGCGRQRDDFVYLFLGPAIGGGIAVDGDCLRGVTGNAGDFAMMPVPPSRLPSVPKPSGAWDLLITRASLNGLARHLRHRGETLESRADLEACIARGGQAVDEWIDDCVDALAPALRAVLAVLESPVVVLDADTDAGLIDTLIARLHTALAALAPEARGTPVLVRGTFGPDAGAIGAATLPMFFNFSPRAGILRGAGVDSQEARYAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P21</accession>
    <name>Q63P21_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase 1</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glxK</name>
        <name evidence="5" type="ordered locus">BPSS0127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004554710.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110148.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0127"/>
    <dbReference type="EnsemblBacteria" id="CAH37572">
        <property type="protein sequence ID" value="CAH37572"/>
        <property type="gene ID" value="BPSS0127"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0127"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6167"/>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CRFEVAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="38980" checksum="28702C7F591FF960" modified="2004-10-25" version="1">MKIVIAPDSFKESLTAVETARQIEAGFREVFADADYRCLPIADGGEGTVDALVAAAGGERRGASVADPLGRPTRAAFGILPDGTAVIEMAEASGLHLVAPDARDPRVTSSRGTGELIRAALDAGARRFIVGLGGSATNDGGAGMLQALGVHLSDADGRPLGPGGAALARLARIDAAGLDGRLAECAFEVACDVDNPLVGPNGASAVFGPQKGATPEMVADLDRHLAHFAAIVARDVGPDVAQLPGGGAAGGLGAAMSAFLGATLRPGVEIVTDALRLRDAIRGASLVVTGEGRIDGQTLRGKAPIGVARIAAECGVPVVAIGGAVTHQAGALYAHGFDAVFASVGRACTIDEALRDAAANVRFAARNVAAAIRVGLKLGRHAPSRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P24</accession>
    <name>Q63P24_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529671.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110145.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0124"/>
    <dbReference type="EnsemblBacteria" id="CAH37569">
        <property type="protein sequence ID" value="CAH37569"/>
        <property type="gene ID" value="BPSS0124"/>
    </dbReference>
    <dbReference type="GeneID" id="56531428"/>
    <dbReference type="KEGG" id="bps:BPSS0124"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6164"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TITMIDN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="230" mass="24592" checksum="D962A81240BA376E" modified="2004-10-25" version="1">MKIDLIVADDHPALIAGIEHALSKSSAISVAGTASNSTELVDLLARERCDILITDYAMPGGSHGDGLGLLSFLRRHYPDLKIIVFTAIDNPALIASMARLGVRAVVNKMDHIDNLIASIQAVYAGATYIPAGVDAFVSSRPAGDEHTPEIERQLSARELEIVRLYVSGLSVNEIAAYLHRSKQAVSTQKMNAMRKLGIERDAGLFRYAYETGLMAAGVPSASPVSAQAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P54</accession>
    <name>Q63P54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative fimbria-related chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS0092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the periplasmic pilus chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110115.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0092"/>
    <dbReference type="EnsemblBacteria" id="CAH37538">
        <property type="protein sequence ID" value="CAH37538"/>
        <property type="gene ID" value="BPSS0092"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0092"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6120"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWIDNGN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036316">
        <property type="entry name" value="Pili_assmbl_chap_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001829">
        <property type="entry name" value="Pili_assmbl_chaperone_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016148">
        <property type="entry name" value="Pili_assmbl_chaperone_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018046">
        <property type="entry name" value="Pili_assmbl_chaperone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02753">
        <property type="entry name" value="PapD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00969">
        <property type="entry name" value="CHAPERONPILI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49584">
        <property type="entry name" value="SSF49584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00635">
        <property type="entry name" value="PILI_CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266211" evidence="7">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="8">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_C" evidence="9">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="27088" checksum="2A82B4265C415B0F" modified="2004-10-25" version="1">MRLWKMCVAVAAACCLASTLSQAAIVITGTRVVYPESSREVNVRLNNVEQSPVLVQAWIDDGNAGASPDEIKVPFVLMPPVFRVEPKKGQTLRVMYTGDDLPKDRESVYWLNVLEIPPKPTVEAEQNLLQLAFRTRIKLFFRPSALEDGNAAQARDQLKWKIVRNEKGVSVLRAENRSPYYISISQATAKSGDKSVQFDPGMVPPFGSKEFVSKRDISTLSTHAEIAYKLLNDYGAEVAGSATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P77</accession>
    <name>Q63P77_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544960.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110092.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0067"/>
    <dbReference type="EnsemblBacteria" id="CAH37511">
        <property type="protein sequence ID" value="CAH37511"/>
        <property type="gene ID" value="BPSS0067"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0067"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6083"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYYCSLH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF756" evidence="3">
        <location>
            <begin position="529"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="3">
        <location>
            <begin position="630"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="731" mass="80839" checksum="6E3C5A7D71141373" modified="2004-10-25" version="1">MNARRRFLQGTATTGIAAATLAAFPLSIRRALAIPANNRTGTIRDVEHIVILMQENRSFDNYFGTLRGVRGFGDRFGIPLPNALTVWQQRNATGALVLPYHLDGSKGNAQRVSGTPHSWDDGQNAWDGGRMYQWPRYKNTASMGYFRESELPFQFALANAFTICDAYHCSMHAGTNSNRMFMWTGTNGPTGAGVASVVNEWDDIGPSTFGYEWKTYPERLQEAGVSWKVYQNMPDNFTDNALAGFRQYRRANEASGKPVSNSDKVVSPAYDPASDDVRNPLYKGIANTMPDGGFLGAFKEDIRAGKLPQVSWVVAPAAYSEHPGPSSPVQGAWYIQEVLDALTATPDVWSKTVLLVNFDENDGYFDHVPSPSAPSLNPDGSPAGKTTLPEADIAFERFTHPKPPGTKSQPQPDARVYGPGVRVPMYVISPWSRGGWVNSQVFDHTSTLRFIEARFGVREPNISAFRRSVCGDLTSAFNFVRPNNEPLPTLAGRKTRAQADALRAAQQQMPQIVPPANGLLPRQETGTRPSRALPYELHVNAVARTLDGTLRLVFANTGQAAAVFHVYDKLNLGRLPRRYMVEAGKQLDDVWAAMTDNGGKYDLWVLGPNGLHRHFTGDMNRLRAGGAPVPEVRVEYDRQHGNVQLLLRNEGARECVFTVRAKAYRDDGPWTFKVKGGAERKHHWKLDGSGNWYDFVVTCDADTGYSRRFAGRVETGEHSVSDPAMGFGDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PF9</accession>
    <name>Q63PF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative branched-chain amino acid ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL3417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195807.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110010.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3417"/>
    <dbReference type="EnsemblBacteria" id="CAH37429">
        <property type="protein sequence ID" value="CAH37429"/>
        <property type="gene ID" value="BPSL3417"/>
    </dbReference>
    <dbReference type="GeneID" id="56593917"/>
    <dbReference type="KEGG" id="bps:BPSL3417"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1769"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDHGQMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="27474" checksum="4CDD5E86D2BCEB33" modified="2004-10-25" version="1">MNHSEREERELNSVESGTPALALAGLEAWYGESHILHGVDLTVHRGEVVTLLGRNGAGRTTTLRAIMGLTGRREGSIRIAGHETIGLPTHKIAHYGVGYCPEERGIFSSLSCEENLLLPPVLGDRKRAMSLEDIYEMFPNLASRRASQGTRLSGGEQQMLAVARILRTGANLLLLDEISEGLAPVIVQALAKMIVTLKARGYTIVMVEQNFRFAAPLADRFYVMEHGRIVEHFGAAELEGKMPVLHDLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PH5</accession>
    <name>Q63PH5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ordered locus">BPSL3401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109994.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3401"/>
    <dbReference type="EnsemblBacteria" id="CAH37413">
        <property type="protein sequence ID" value="CAH37413"/>
        <property type="gene ID" value="BPSL3401"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3401"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3869"/>
    <dbReference type="eggNOG" id="ENOG5032S3K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPELMNE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH37413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="91" mass="9303" checksum="F1187B4FE9DA8FF4" modified="2004-10-25" version="1">MIMQAFIANIQGLTAIGIGIIIGLGAIGACIGIALMGGKYIEACARQPELINPLQTKMFLLAGLIDAAFLIGVGVAMLFAFANPLLSKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PJ0</accession>
    <name>Q63PJ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fatty-acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185142.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109979.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3387"/>
    <dbReference type="EnsemblBacteria" id="CAH37398">
        <property type="protein sequence ID" value="CAH37398"/>
        <property type="gene ID" value="BPSL3387"/>
    </dbReference>
    <dbReference type="GeneID" id="56593884"/>
    <dbReference type="KEGG" id="bps:BPSL3387"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1807"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGWHHTG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="416"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="515" mass="55089" checksum="3EE51FC30ADDD4C8" modified="2004-10-25" version="1">MNLIAALERAARATPDKPFLRDDGATLTYRQMQQRSRRAAEVLASLGVAPGERVAAMCLNTPAFFDLLLGAWRIGAVVVPVNHKLQAPEVDHILRHSASRAVLFDAALAPVLANVEHDALRLATEGEAAGAAPFDRLVADAAGIAPATPDDAALAEILYTSGTTGRPKGCMHSHRTVALAAATSALALSMTERERTLMAMPVWHASPLNNWFGGTLYVGGTVVLMREYQPLRFLQTVEAEQVTLYFGAPVSYTLPLDTIADFASFDLTSVRAWLYGGGPIGATLARRLMRAYRSEAFYQVYGMTETGPAGTVLHPFEQAMKPGSIGCQGTPGVDVRVVTAAGGLARPGEIGEIRLRADSMMLGYLDDPGATRAAFDDDGWYRSGDVARVDDDGYLFVVDRIKDMIVTGGENVYSKEVEDVLNAHPAVAEAAVVGRAHPEWGETVIAHVVLREAAGAARAGQAESAAGVDADALRAFCATRLAAYKIPREYVFAERLPRTPTGKLQKYLLRARGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM0</accession>
    <name>Q63PM0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL3354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552489.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109949.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3354"/>
    <dbReference type="EnsemblBacteria" id="CAH37367">
        <property type="protein sequence ID" value="CAH37367"/>
        <property type="gene ID" value="BPSL3354"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3354"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1849"/>
    <dbReference type="eggNOG" id="COG3245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VNDRIKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002323">
        <property type="entry name" value="Cyt_CIE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40942">
        <property type="entry name" value="PTHR40942"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00607">
        <property type="entry name" value="CYTCHROMECIE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="219"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="29860" checksum="AA1425455962C163" modified="2004-10-25" version="1">MSEAPHGAPIKTPGQLIAVVIASFVIPIAIIVLFATYANHAFRTGAGTDGLSDEAVAKRIAPLAQVDIKDANAPHVYKTGEEVYKAVCVTCHGTGAAGAPKFGDAAAWAPRIAAGYDEVLHLALTGKGAMPPRGGTNPDDYSDYEIARAVVYMANQGGAKFAEPAQPAANAAPASGAAAASAPGASDAAANSQAAAAMAAIAALPKAGEAPAAGANAESSASAGKALYESTCQACHATGVLNAPKFGNKADWAPRLKDSMDTVYNFALHGKGAMPPKGGSNASDADVKAAVDYMVNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PS0</accession>
    <name>Q63PS0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cheR</name>
        <name evidence="9" type="ordered locus">BPSL3303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525698.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109899.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3303"/>
    <dbReference type="EnsemblBacteria" id="CAH37316">
        <property type="protein sequence ID" value="CAH37316"/>
        <property type="gene ID" value="BPSL3303"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3303"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1913"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWQEFVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="35490" checksum="EF6AC1F90CDBF557" modified="2004-10-25" version="1">MMPARAASRLDAPEPQERSGDAARDFEFTSADFTKIRALIHRRAGISLSEHKRDMAYSRLARRLRARGLNRFCDYLELLERENDPSEWEAFTNSLTTNLTAFFRESHHFPILAEFVKRREQPVSVWCSAASTGEEPYSIAMTLVEALGESAARSASVIATDLDTQVLAKADAGVYAFEQVKHLSPERLKRFFLKGTGAQAGRVKVRPELRAMIRFAQLNLTDADYGLTKPFDAIFCRNVMIYFDKPTQSQVLARFEPLMKPGGLLFAGHSENFTYVTQAFRLRGQTVYELTRDGQSAAPRVRARIAAAAAEEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PV5</accession>
    <name>Q63PV5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109863.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3267"/>
    <dbReference type="EnsemblBacteria" id="CAH37280">
        <property type="protein sequence ID" value="CAH37280"/>
        <property type="gene ID" value="BPSL3267"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3267"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1956"/>
    <dbReference type="eggNOG" id="ENOG5033QW9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSWIVSR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="27410" checksum="F57DF3D1215BFBA1" modified="2004-10-25" version="1">MARPARSDSEKKRGGMRAAALLHALARHVGAENPYQFATRFDARMNSTTHTSGKWRLNFAGSQALSINQLKLLSQFDARANLLHVRGPADLWIALWGDAHDLWQLCRSRLCHMGPSLDDRIWLEVAGEFTDEKAFDVTLADFEGEVLLAEAYQALLPLRYLSEAVALHRLFQTLNTLALLSFDGAGTYRCVRICLDNANVAAELSHHGILESVRDELAVIVTRPEAAVPAEQRWEALRPRLDWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PX0</accession>
    <name>Q63PX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525670.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109848.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63PX0"/>
    <dbReference type="STRING" id="272560.BPSL3254"/>
    <dbReference type="EnsemblBacteria" id="CAH37265">
        <property type="protein sequence ID" value="CAH37265"/>
        <property type="gene ID" value="BPSL3254"/>
    </dbReference>
    <dbReference type="GeneID" id="56527893"/>
    <dbReference type="KEGG" id="bps:BPSL3254"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1979"/>
    <dbReference type="eggNOG" id="COG1656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VPHTEVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="96"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="28630" checksum="DC078FA6ABD2CD91" modified="2004-10-25" version="1">MVTVTFRFYEELNDFLARPLRRREFAHACMRGASVKHAIEALGVPHTEVELILVNGESTPFSHVLEEGDRVAVYPSFEAIDIRPLLRVRAAPLRVTRFIADAHLGGLAQLLRLAGFDTLYDNHYPDELIETIAAREARIVLTRDRELLKRRTITHGCYVRALKPQAQLQELFDRLDLAGSARPFRLCLSCNAPLRRIDPAEAAGRAPQGVLQRHTRFVTCDVCRRVFWEGSHWRRMRALIEHVSQPKPPPG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q34</accession>
    <name>RS13_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">BPSL3190</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197938.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109784.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q34"/>
    <dbReference type="SMR" id="Q63Q34"/>
    <dbReference type="STRING" id="272560.BPSL3190"/>
    <dbReference type="EnsemblBacteria" id="CAH37201">
        <property type="protein sequence ID" value="CAH37201"/>
        <property type="gene ID" value="BPSL3190"/>
    </dbReference>
    <dbReference type="GeneID" id="56594566"/>
    <dbReference type="KEGG" id="bps:BPSL3190"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2048"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230485" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="121" mass="13562" checksum="7F51A19C56E31150" modified="2004-10-25" version="1">MARIAGVNIPNHQHTEIGLTAIFGIGRTRARSICVASGVAFSKKVKDLTDADLEKLREEVGKFVVEGDLRREVTMNIKRLMDLGCYRGVRHRKGLPLRGQRTRTNARTRKGPRRAAQALKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q37</accession>
    <name>RPOA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">BPSL3187</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197925.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109781.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q37"/>
    <dbReference type="SMR" id="Q63Q37"/>
    <dbReference type="STRING" id="272560.BPSL3187"/>
    <dbReference type="EnsemblBacteria" id="CAH37198">
        <property type="protein sequence ID" value="CAH37198"/>
        <property type="gene ID" value="BPSL3187"/>
    </dbReference>
    <dbReference type="GeneID" id="56594569"/>
    <dbReference type="KEGG" id="bps:BPSL3187"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2051"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175283" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="325" mass="35685" checksum="8E63BDEC237B1E0A" modified="2004-10-25" version="1">MQTSLLKPKIIAVESLGENHAKVVMEPFERGYGHTLGNALRRVLLSSMVGYAPTEVTIAGVVHEYSTLDGVQEDVVNLLLNLKGVVFKLHNRDEVTVTLRKEGEGVVTAGDIELAHDCEVINPNHVIAHLSKGGKLDVQIKVEKGRGYVPGNVRRYGDETAKIIGRIVLDASFSPVRRVSYTVESARVEQRTDLDKLVMNIETSGVITPEEAIRQSARILVDQLSVFAALEGTETAAEAPSRAPQIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTENELLKTPNLGRKSLNEIKEVLASRGLTLGMKLENWPPAGLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QA3</accession>
    <name>Q63QA3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Cytochrome b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">petB</name>
        <name evidence="19" type="ordered locus">BPSL3122</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15">Binds 2 heme groups non-covalently.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="14">Binds 2 heme groups non-covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cytochrome b family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199894.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109715.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3122"/>
    <dbReference type="EnsemblBacteria" id="CAH37132">
        <property type="protein sequence ID" value="CAH37132"/>
        <property type="gene ID" value="BPSL3122"/>
    </dbReference>
    <dbReference type="GeneID" id="56594106"/>
    <dbReference type="KEGG" id="bps:BPSL3122"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2121"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFFAFHF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00284">
        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030689">
        <property type="entry name" value="Cytochrome_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038885">
        <property type="entry name" value="COB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="17">
        <location>
            <begin position="13"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="18">
        <location>
            <begin position="235"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038885-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038885-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAH37132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="460" mass="52404" checksum="F4965145D6578E80" modified="2004-10-25" version="1">MATDNKEISTTGLLGWVDRRFPLTSTWKQHLSEYYAPKNFNVWYFFGSLALLVLVNQIVTGIFLTMNYKPDSTLAFASVEYIMREVPWGWLIRYLHSTGASMFFVVVYLHMFRGLLYGSYRKPRELVWIFGCAIFLCLMAEAFFGYLLPWGQMSFWGAQVIVNLFSAIPFVGPDLSLWIRGDYVVSDVTLNRFFAFHVIAIPLVLLLLVVAHLIALHEVGSNNPDGIEIKEKKDEKGVPLDGIPFHPYYSVHDFFGVCVFLMVFALIVFFMPEMGGYFLEANNFIPANPLQTPPEIAPVWYFTAFYAMLRATTDPFKIVLMIVIAALGLLALVRARGKWKIALPVLAAALVVFMYFTESKFWGVVVMGGAVVTLFFLPWLDRSPVKSIRYRPFFHKVFFGIFVVVFLTLAFLGTRPPSPAATLIAQVCALVYFAFFLGMPFWTPLGTFKQPPERVRFKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QC4</accession>
    <name>Q63QC4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL3099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205261.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109694.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3099"/>
    <dbReference type="EnsemblBacteria" id="CAH37110">
        <property type="protein sequence ID" value="CAH37110"/>
        <property type="gene ID" value="BPSL3099"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3099"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2144"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MKGEVHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267444" evidence="4">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="195"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="310" mass="31942" checksum="EC4596CADE730E5D" modified="2004-10-25" version="1">MTKPRLPLLRARRFALAFAALALGGAARADNVGPATVTAIDAGGVPVKSVPLAAPVTAAPVAATAGAGATVSSPPPANATPGQVVAGGKVADEATKAAVLQRLRDTYGAANVVDQIEIGNVATPPNWSANVQKLIGPQLKQISKGQLKIDGTQIDVKGEVHNEAQRQQLASDMANALNPTYTIKNGLRVSASEQGLLDQTLANRTIEFETGSATLTPQGRAILDQMAGALAKMSNRTVEIIGHTDNSGNRTSNIALSQARADAVKGYLVTKGIASQQLTTTGVGPDQPIAPNDSADGRARNRRIEFRAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI0</accession>
    <name>Q63QI0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable enoyl-CoA hydratase PaaG</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">paaG</name>
        <name evidence="3" type="ordered locus">BPSL3043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186957.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109638.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3043"/>
    <dbReference type="EnsemblBacteria" id="CAH37054">
        <property type="protein sequence ID" value="CAH37054"/>
        <property type="gene ID" value="BPSL3043"/>
    </dbReference>
    <dbReference type="GeneID" id="56597098"/>
    <dbReference type="KEGG" id="bps:BPSL3043"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2224"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPDLHWK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011968">
        <property type="entry name" value="PaaB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02280">
        <property type="entry name" value="PaaB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="263" mass="28400" checksum="26AD059478A549DC" modified="2004-10-25" version="1">MSYQTIRIEIDQAAQIATITLDRPDKLNSFTRDMHRELQSALDDVQAANARALVLTGAGRGFCAGQDLADLDFTPGAMTDLGEVIEAHFNPLVRRLQALPLPVIAAVNGTAAGAGANLAFACDLVIAAKSSSFIQSFVKIGLVPDSGGTWFLPQRVGFARALGLALTGDKLSAEQAERWGLVWRVVDDAELAGAAAQLARELAQQPTRAIAAIKQAMRASLTHTLDQQLDLERDLQRELGQSYDYAEGVRAFIEKRAPRFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QJ3</accession>
    <name>Q63QJ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ordered locus">BPSL3029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194098.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109625.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3029"/>
    <dbReference type="EnsemblBacteria" id="CAH37041">
        <property type="protein sequence ID" value="CAH37041"/>
        <property type="gene ID" value="BPSL3029"/>
    </dbReference>
    <dbReference type="GeneID" id="56594288"/>
    <dbReference type="KEGG" id="bps:BPSL3029"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2237"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="108"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="318"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="468" mass="47757" checksum="DD2E021C3FACAE16" modified="2004-10-25" version="1">MTMLTLREAAAMIPGATVLGDERASFERVSTDSRSAGPGDLFVALKGERFDAHDFVGDVAARGASAAIVSRSPAEWNLPALKVADTRAALGALAHGWRMRFSMPLVAVTGSNGKTTVKEMIASIFAAAVGEHARLATAGNFNNDVGLPLTLLRLNAAHRLAVVELGMNHPGETEMLAKIAAPTVALVNNAQREHQEFMATVEAVALEHAAVIHALGPDGVAVFPADDAYAGIWRVAATGNRIVDFALHGAAGGAPAAVTGALDGSLLAIDTPGARIDVRLNALGEHNARNALAATAAALAAGVPLAAIKAGLEAFAPVKGRLQVARAAAGSLAGATVIDDTYNANPDSMRAAIDVLAAQSAPRVLVIGEMGEVGDEGPAFHREIGAYARERGIDALFALGAATRPACDAYGAGARHFDDAAALVAALLAANFGAHATLLVKGSRFMKMERVVDALANETASGAAPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU5</accession>
    <name>Q63QU5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL2929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194283.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109523.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2929"/>
    <dbReference type="EnsemblBacteria" id="CAH36939">
        <property type="protein sequence ID" value="CAH36939"/>
        <property type="gene ID" value="BPSL2929"/>
    </dbReference>
    <dbReference type="GeneID" id="56593766"/>
    <dbReference type="KEGG" id="bps:BPSL2929"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2352"/>
    <dbReference type="eggNOG" id="COG3265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ENFIQVS"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="19736" checksum="18F908EB1CC78F5D" modified="2004-10-25" version="1">MILIAMGVSGAGKSRIGEMLAQRLSCSYTDGDAFHSAANKEKMHHGIALTDEDRWPWLRSIREAIEARQRAGETAVFTCSSLKRAYRDILRGNDRDVRFVYLKGSFDVLRERLKTRTGHFFDPSLLQSQLDTLEEPGPDEAIEVSIELTPDEIVERVMRELDRERQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RF7</accession>
    <name>Q63RF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541290.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109311.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2715"/>
    <dbReference type="ESTHER" id="burma-q62i62">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36723">
        <property type="protein sequence ID" value="CAH36723"/>
        <property type="gene ID" value="BPSL2715"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2715"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2616"/>
    <dbReference type="eggNOG" id="COG2939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TATAWYH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266724" evidence="1">
        <location>
            <begin position="25"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="615" mass="66045" checksum="E1FC0048D833AA12" modified="2004-10-25" version="1">MKIQKSLKDGFTLGWCRAARPVAAAALAALLVAACGGDDGGGGSPSLAAANVANTSTSTNATTAADATTNAALPPDQPYIDNDVYGTGPNDSVSDATEGTAVVHRQVKIGDQILTYTATVGHLVTIDPITSKPNAKMFYVAYTLDNPNPGKPRPVTFFYNGGPGSSSVYLLLGSFGPKRLQSSFPNFTPPAPYRLRDNPESLLDRSDLVFINPVGTGYSAAIAPAKNKDFWGVDQDAHSIDRFIQRYLTKYARWNSPKFLFGESYGTARSAVTAWVLHEDGIELNGITLQSSILDYANAVSAIGIFPTLAADAFYWNKTTISPKPADLDAYMAQARSYADNVLAPLAQAPNPQDGGFVNVRLNLNVATAQQMGAYIGTDPISLVQTFGNPAALGNVPSSNDNPPYTFFLTLVPGIQIGQYDGRANYTGKGIAPYILPNSGSNDPSISNVGGAYTVLWNDYINNDLKYVSTSSFVDLNDQVFNNWDFSHTDPTGANRGGGNTLYTAGDLAATMSLNPDLKVLSANGYFDAVTPFHQTELTLAQMPLDPSLKSANLTMKYYPSGHMIYLNDHSRIAMKADLATFYDGILADRTAMRRVLLRQQKALQLKQQKQQQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RJ0</accession>
    <name>Q63RJ0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">wzm</name>
        <name evidence="8" type="ordered locus">BPSL2682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186421.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109278.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2682"/>
    <dbReference type="EnsemblBacteria" id="CAH36690">
        <property type="protein sequence ID" value="CAH36690"/>
        <property type="gene ID" value="BPSL2682"/>
    </dbReference>
    <dbReference type="GeneID" id="56594998"/>
    <dbReference type="KEGG" id="bps:BPSL2682"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3055"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFAWFQK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="277" mass="30629" checksum="A5A50FFEE7379636" modified="2004-10-25" version="1">MSIISVFTSAPGDLVSSVARNASLIWQMTKREVVGRYRGSVLGLAWSFFNPLLMLAVYSFVFSFVFKSRWGGGAEDQGRAQFAMMLFVGMTIHGLFAECVNRAPSLILNNPSYVKKIVFPLEILPIVALLSAFFHTLVSLAVLLLGFALFKHFVFASALFLPIVLLPLMLMSLGVAWFLAATGVFVRDVGQITGLFTMVLMFLSPVFYPASALPEKYRFWLELNPLTLFIEQSRGILLEGRVPDFHPLGLAFLGGVAVACAGFKYFQLMRKGFADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RQ5</accession>
    <name>Q63RQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC-family amino acid transporter, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522302.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109212.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2616"/>
    <dbReference type="EnsemblBacteria" id="CAH36624">
        <property type="protein sequence ID" value="CAH36624"/>
        <property type="gene ID" value="BPSL2616"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2616"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2737"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EMFAQGK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="219" mass="23243" checksum="824BD348327C273A" modified="2004-10-25" version="1">MQAFDLVVHTLPVLAKGAALTMKFAVASMVLGLIVGLLVALVRIGSNRLLSAIAQGYVSLMRGTPLLVQMFVVYYGLPDIGISLDPTAAGIFTLTLNAGAYLSESMRGAILGIGRGQWAASHSLGLTHVQTLRHVICPQALRLAVPSLGNTLISLIKDTSLVSVITVTELLRSTQEVIASTFQPLPLYLAAAAIYWVLSTLLARLQGRIETRCALPSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RQ6</accession>
    <name>Q63RQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, substrate binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522303.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109211.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2615"/>
    <dbReference type="EnsemblBacteria" id="CAH36623">
        <property type="protein sequence ID" value="CAH36623"/>
        <property type="gene ID" value="BPSL2615"/>
    </dbReference>
    <dbReference type="GeneID" id="56528584"/>
    <dbReference type="KEGG" id="bps:BPSL2615"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2738"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPTKWDG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267485" evidence="4">
        <location>
            <begin position="27"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="38"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="28340" checksum="DD018AB684298C18" modified="2004-10-25" version="1">MKAFKPMFTSALVAALLGVAAASAHAADLLDSVKQAGVLKIALEGTYPPFDYRNGDGQLEGFDVDVAKEVAARLGVKPQFVTTEWSGILAGLQAGKFDVIVNQVGITPARRQALDFSQPYVYSAAQLIQRADDKHDYGAPGALQGKRIGVTLGTNFADLAKTLQGVDVKTYPGAPEKLRDVAAGRIDVSMDDRLMLPYLIKNAHMPLRPGATINGGETQMGIPFRKGNPKFAKALDDALASMRADGTLKKISVHWFGVDTSVPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RY7</accession>
    <name>Q63RY7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate-proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">citA</name>
        <name evidence="7" type="ordered locus">BPSL2534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522345.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109130.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2534"/>
    <dbReference type="EnsemblBacteria" id="CAH36541">
        <property type="protein sequence ID" value="CAH36541"/>
        <property type="gene ID" value="BPSL2534"/>
    </dbReference>
    <dbReference type="GeneID" id="56528649"/>
    <dbReference type="KEGG" id="bps:BPSL2534"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2844"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LLMVELW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="431" mass="46469" checksum="3B4F05B57AEEF0DE" modified="2004-10-25" version="1">MSTASPAIQQESKARTVFRVVSGNFLEMYDFMVYGYYASAIAKTYFPSGNAFASLMLSLSVFGAGFLMRPVGAIVLGAYIDHHGRRKGLILTLALMALGTLTVATIPGYATIGVLAPILVLLGRLLQGFSAGVELGGVSVYLSEIATKGNKGFYTSWQSGSQQVAVVFAAFVGVLLNRALPVEQMTSWGWRIPFLIGCLIVPFLFLIRRSLKETDEFLAKRRRPSMGEIMKSMLENWGVVLAGMGMVIMTTVSFYMITAYTPTFGKEVLHLSAIDALVVTVCVGLSNLVWLPLSGALSDRIGRRPVLIAFTALTILTAYPAMQWLVGSPSFLRLLGVELWLSFLYGSYNGAMVVALTEVMPADVRTAGFSLAYSLATTIGGFTPAISTLLIHETGNKAAPGLWLGLAAICGLIATLVLYRSPEARNQYKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S20</accession>
    <name>Q63S20_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, membrane permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522364.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109097.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2502"/>
    <dbReference type="EnsemblBacteria" id="CAH36508">
        <property type="protein sequence ID" value="CAH36508"/>
        <property type="gene ID" value="BPSL2502"/>
    </dbReference>
    <dbReference type="GeneID" id="56528679"/>
    <dbReference type="GeneID" id="66547912"/>
    <dbReference type="KEGG" id="bps:BPSL2502"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2880"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFWSAIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="217" mass="22929" checksum="DA384E9E591D983D" modified="2004-10-25" version="1">MLSEMFDMFVQSFWETLIMVGISGAVGALVGLPLGVLLYLTDRQGVLQNLAVNRVLGGVVNAVRSTPFIILLVAVIPFTRLAVGSSIGTAAAVVPLTIAAAPFIARLVETALREVDRGLIEAAQAMGATTGQIVFKVLLPESLPGIVAGLTITFVSLVGYSAMAGAIGGGGLGDLGIRYGYQRYLPEVMWTVVAILIVFVQIVQSFGDWLVRRLSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S52</accession>
    <name>Q63S52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative prolin-rich exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109065.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2472"/>
    <dbReference type="EnsemblBacteria" id="CAH36476">
        <property type="protein sequence ID" value="CAH36476"/>
        <property type="gene ID" value="BPSL2472"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2472"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2817"/>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVAWFPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266745" evidence="2">
        <location>
            <begin position="35"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="857" mass="91105" checksum="D5B028D350C55576" modified="2004-10-25" version="1">MTMLATRHPFALTRIARHTLVAVAMLAALPPAIAQNVAPPPAGVARQTGGDPPSRVARLNYLSGAVTTEPAGASDWSYAAVNRPLTTGDQLWNDSGARSELHIGSTAVRLGQSTSLSILNLDDANTQLKVPLGTLSTHVRELPPGTSYEIDTPNLALAVGAPGDYRVDVAPDGSSTTVTVRRGSATVYGDGTQMPVSAGQRVVFTGTALQVADTGAVPPPDGLDEWVASRDAAEERSVSARYVSREIPGYQDLDANGTWRENPDYGEVWVPSAVPAGWAPYRTGHWIWQAPWGWTWVDDEPWGFAPYHYGRWAYVDDSWAWVPGPLVVSAPPCYAPALVAFVGGGGGGFDWSVGLAIGGIAAAGVAWFPLGPRDPWRPSWGGWSPHYYQHVNQTVIVNNVNNINVNKTVNVTNITNITNIHNTYVNFRAPNAVTAVPATAFVHGQPVSRFAQKVDPQQWRNAHIGSGAPGVAPVRQSFTGALRNAAYRPPAAVAQRSIVATRNPAVPAAYHDQLAAHLAQSGARVPGAGAPVVKTAVPPNYAMRPVRTPENTGAPNRWAMRNVQLVDTRSSVAQPERAPQAGAGNPAARAGERPQPNMPQPNAAQPNAAQPNIARPGQPQPGVAQPTAPHAPGTPPNAMRPDAARPNEARPAPAPSARNGVPRPPAAVENPGMRDEARAPGEAPRPQPSWTQPHPPIQQQRANEGGPRASGEPNAPLNYRSPTQNALPPIRSTPTPTHSAPPAPPPAERAQPQPGPAPRNAMRAPEAPRQEVAPPAPRNEYRAPAPAPRPQIEAPRMEAPRMPAPRAEAPRMEPRPAPPPPAVPHNPPPAPRQEPPHQARPDQQHGFAPRREERRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S67</accession>
    <name>Q63S67_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527474.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109050.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2458"/>
    <dbReference type="EnsemblBacteria" id="CAH36461">
        <property type="protein sequence ID" value="CAH36461"/>
        <property type="gene ID" value="BPSL2458"/>
    </dbReference>
    <dbReference type="GeneID" id="56528726"/>
    <dbReference type="KEGG" id="bps:BPSL2458"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2932"/>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDSKMQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="491" mass="53946" checksum="178AE18B4503F733" modified="2004-10-25" version="1">MTETLLLAAIVALAVALVVALVMLLRGGPRGGGLERLAEQIDDANDAHAHAAERLERELRAEIVDGARHSRTELAGNFAQLQQTLAAQLTSVATVQNNQIDGFAQQLAKLVAGNTQQFDAMRDTLQRQAQLAREEQGTALRHFGDTLNQQLTQLTQANDRRIGEVRATLETRLKEIEANNAAKLEEMRRTVDEKLHATLEQRLGESFKLVSDRLEQVHRGLGEMQTLAAGVGDLKKVLTNVKTRGTWGEVQLEALLEQMLTPDQYAKNVATVPKSGERVEFAIRLPGRHDEGAAGGAEPVWLPIDAKFPREDYERLIDAQERADAAAVEEAARALEARIRAEARTIAEKYVAPPHTTDFALLFLPTEGLYAEILRRPGLTDLLQRDYRVTVAGPTTLTALLNSLQMGFRTLAIEKRSSEVWQVLGAVKTEFGKFGDVLARTKSQLETVTRSIEAAEQRTRVMNRKLKQVEALPGEAANGLLGVDGAEADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SB6</accession>
    <name>Q63SB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferases group 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192961.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109000.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2408"/>
    <dbReference type="EnsemblBacteria" id="CAH36411">
        <property type="protein sequence ID" value="CAH36411"/>
        <property type="gene ID" value="BPSL2408"/>
    </dbReference>
    <dbReference type="GeneID" id="56596319"/>
    <dbReference type="KEGG" id="bps:BPSL2408"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2987"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRHYGPW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="354" mass="39841" checksum="20C67F85ABAEAEAF" modified="2004-10-25" version="1">MRIAQIAPLHEAVPPKLYGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEAVWPQALRLDPTIRDVMAPHMLLLEEVRRRADEFDVLHFHIDYYPFPLFSRQPVPHLTTLHGRLDLPELQPIFNTFSDVPVVSISDNQRIPLSQANWLQTTYHGLPENLLKPIPDVKPSYLAFLGRISPEKRVDTAIRIAEQAGMPIKIAAKLDKADRAYYEEKIKPLFSLPHVEYIGEISEAEKADFLGNAHALLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIENGVSGFVVEDELSAVAAVKRLNTLPRERVRAAFDARFTSKVMAQNYVKGYEELLRRKRRTVLREVNAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SJ4</accession>
    <name>FETP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable Fe(2+)-trafficking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL2326</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fe(2+)-trafficking protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193961.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108922.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SJ4"/>
    <dbReference type="SMR" id="Q63SJ4"/>
    <dbReference type="STRING" id="272560.BPSL2326"/>
    <dbReference type="EnsemblBacteria" id="CAH36329">
        <property type="protein sequence ID" value="CAH36329"/>
        <property type="gene ID" value="BPSL2326"/>
    </dbReference>
    <dbReference type="GeneID" id="56596125"/>
    <dbReference type="KEGG" id="bps:BPSL2326"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3097"/>
    <dbReference type="eggNOG" id="COG2924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SKQTMLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3880.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00686">
        <property type="entry name" value="Fe_traffic_YggX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007457">
        <property type="entry name" value="Fe_traffick_prot_YggX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036766">
        <property type="entry name" value="Fe_traffick_prot_YggX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36965">
        <property type="entry name" value="PTHR36965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04362">
        <property type="entry name" value="Iron_traffic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029827">
        <property type="entry name" value="Fe_traffic_YggX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111148">
        <property type="entry name" value="SSF111148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000214474" description="Probable Fe(2+)-trafficking protein">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00686"/>
        </source>
    </evidence>
    <sequence length="91" mass="10376" checksum="2CA3A83A67D5C8F0" modified="2004-10-25" version="1">MARMIHCAKLGKEAEGLDFPPLPGELGKRLYESVSKQAWQDWLKQQTMLINENRLNMADPRARQYLMKQTEKYFFGEGADQASGYVPPAQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ST0</accession>
    <name>ACCA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="1">ACCase subunit alpha</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accA</name>
        <name type="ordered locus">BPSL2241</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193249.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108836.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63ST0"/>
    <dbReference type="SMR" id="Q63ST0"/>
    <dbReference type="STRING" id="272560.BPSL2241"/>
    <dbReference type="EnsemblBacteria" id="CAH36243">
        <property type="protein sequence ID" value="CAH36243"/>
        <property type="gene ID" value="BPSL2241"/>
    </dbReference>
    <dbReference type="GeneID" id="56596032"/>
    <dbReference type="KEGG" id="bps:BPSL2241"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3196"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000223746" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01137"/>
        </source>
    </evidence>
    <sequence length="323" mass="35667" checksum="2A95695D449EF04F" modified="2004-10-25" version="1">MKTTFLDFEQPIAELEAKIEELRFVQDDSAVDISEEIERLSKKSQQLTKDLYANLTPWQVSQIARHPQRPYTLDYVSELFTDFHELHGDRAFADDQSIVGGLARFNGHACMVIGHQKGRDTKERAARNFGMPRPEGYRKAERLMRVAEKFGLPIFTFVDTPGAYPGVGAEERGQSEAIGHNLYVMAELKTPIIATVIGEGGSGGALAIAVADTVMMLQFSTYSVISPEGCASILWKSAAKAPEAAEALGLTAHRLKALGLIDKIVNEPLGGAHRDPKGMAALLRRALGDSLRQFQGMSVDALRERRFERLMAYGKFKETTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV7</accession>
    <name>Q63SV7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550247.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108809.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2214"/>
    <dbReference type="EnsemblBacteria" id="CAH36216">
        <property type="protein sequence ID" value="CAH36216"/>
        <property type="gene ID" value="BPSL2214"/>
    </dbReference>
    <dbReference type="GeneID" id="56596001"/>
    <dbReference type="KEGG" id="bps:BPSL2214"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3231"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAFGPAH"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="112"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="898" mass="96122" checksum="C226402F10F10FC9" modified="2004-10-25" version="1">MTGIFVFIESNTTGTGELLVRKALQRGLTPYFLTANRGKYPFLDAIRVVTISLDTSDADRIHRFVSSLDGVAGVMSSSEYFIEVASEVARRLGLPTANTEATRVCRDKKRLARTLAEHGIDVPRTHALALDADADADAVALSALDGLAYPVVVKPRMGSGSVGVRLCASVDEVAEHCAALRRAGTRAALVQAYVEGDEYSVETLTVARSTQIVGIVRKRLGREPHFVEIGHDYPAPLSSPQRERIERTVLRALEALGYAFGPAHTELRVRGDTVTIIEINPRLAGGLIPVLLGEVFDVDLLDHVLDMWLGVAAFADLTAKRYGAIRFALPAREGVLRGPLALPADIAARPELRHFHPIAQPGDALRLEGSFRDRIAAVVCAGDHRESVEALAERAVAGLSIDIGDDARAAALNESNESNGANAATPGLPPRLQAIVYGDGASEAPLAELDHLFDLNEAHLVMLGATRIVAPERVRPLLDAHRRLRRAGYAPLLARPRPRGLYMLVEAYLIETLGEDVGGVLQTGRSRNDINAATTKLHLRDATSRAFDALWRLRRSLVFKASANVDCAFPIYSQYQPALPGTLAHQLLAFDGALAHETHALFALFQHIDVCPLGAGAGGGTTLPIDPEFVCRLLGFEQPAPNSLDAVANRSGVVHFLSAMNAIGLVLSRLAQDLQIWTTAEFALVSLPAALTGGSSMLPQKKNPFLVEFVKSRAGVPFGALASCSAALGKTPYTNSFEAGSPMNGLIAQACAAIEDAAAVAVLLIDGLEAAQARIDAHLRDTGVVAMAVAESLVVRRSIDFRSAHTRVAQAVRDSAAQGRSSHDALAALDPDFVSRAPLEWARSHRFGGGPGAADLNHGVARACRALADDEAVFRRKQDVWREAEQMRRLAAQQLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SY7</accession>
    <name>Q63SY7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rimI</name>
        <name evidence="7" type="ordered locus">BPSL2184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108779.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2184"/>
    <dbReference type="EnsemblBacteria" id="CAH36186">
        <property type="protein sequence ID" value="CAH36186"/>
        <property type="gene ID" value="BPSL2184"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2184"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2481"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GERYLNY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017189">
        <property type="term" value="P:N-terminal peptidyl-alanine acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02210">
        <property type="entry name" value="RimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043690">
        <property type="entry name" value="RimI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="18098" checksum="F438ACC3F7D1B5E3" modified="2004-10-25" version="1">MTDRYLAPMTDADLDEVVEIERAAYEFPWSRGNFEDSLRNGYFGVCMRHVTGVLVGYCVLMPVVDEMHLLNLCVAPVAQRSGVGLALLREAVRIARAERLDGVLLEVRPSNPRAIRLYERFGFVSVGRRRNYYPAKHRSREDAIVMRLALTKEGGAHGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH7</accession>
    <name>Q63TH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar ABC transport system, substrate-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192875.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108589.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1991"/>
    <dbReference type="EnsemblBacteria" id="CAH35990">
        <property type="protein sequence ID" value="CAH35990"/>
        <property type="gene ID" value="BPSL1991"/>
    </dbReference>
    <dbReference type="GeneID" id="56595406"/>
    <dbReference type="KEGG" id="bps:BPSL1991"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4143"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DNIELRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267541" evidence="1">
        <location>
            <begin position="33"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="37"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="349" mass="37275" checksum="E881250BD0D8161A" modified="2004-10-25" version="1">MRLCTGKAVLRACVAAIAVAAGVGGAAPAAQAAGARFALVSHAPDSDSWWNTIKNAIKQADEDFDVTTDYRNPPNGDIADMARLIEQSAARDYDGVITTIADYDVLKNSLKKVTAKKIPLVTINSGTEEQSAQLGAIMHVGQPEYVAGHAAGEKAKAAGVKRFLCVNHIATNSVSFDRCRGFADAIGADYKSSTIDSGQDPTEIQSKVSAYLRNHPNTQAILTLGPVPAAASLKAVQQMGLANKLFFATFDFSDDIAKAIQSGAIKFAIDQQPYLQGYIPVAVLAIAKQNKTTDPAKIRQILEANPKFQARLSTYGLQPSYGPKNIRSGPGFITKENLEKVIKYAGQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U08</accession>
    <name>Q63U08_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amino acid transport system, exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193804.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108408.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1809"/>
    <dbReference type="EnsemblBacteria" id="CAH35808">
        <property type="protein sequence ID" value="CAH35808"/>
        <property type="gene ID" value="BPSL1809"/>
    </dbReference>
    <dbReference type="GeneID" id="56595598"/>
    <dbReference type="KEGG" id="bps:BPSL1809"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3930"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITYFMDG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266583" evidence="2">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="35"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="271" mass="29579" checksum="73F08BF05E66F61D" modified="2004-10-25" version="1">MKFKPFATWLLGLSLVAAHAAAHADRLDDIRKAGVLRVATFDSNPPFGFVDPRTNRIVGLDVDYAQALADRLGVKLKLQPTNPANRIPFLTSGKVDLVLANFTITDERAKQVDFSVPYFASGQQFLAKKGVLKSADQLNRLRIGADKGTTNEVTLREKYPQATIVAYDDTPFAFAALRAGNVQAITQDGPKLIGLLANVPDKQNYEVPAFSISNDYMGVGAPKGEPRLVAFVNETLTDLEASGRAGRIYDAWFGPNTKTPLARIFKIGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U42</accession>
    <name>Q63U42_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative siderophore biosynthesis related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937484.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108374.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1774"/>
    <dbReference type="EnsemblBacteria" id="CAH35773">
        <property type="protein sequence ID" value="CAH35773"/>
        <property type="gene ID" value="BPSL1774"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1774"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3881"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITRIESP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="123"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="30999" checksum="D9ED96F8FFABDF3B" modified="2004-10-25" version="1">MAKKKLVYIWSLRNAAADKAGQQVDYKGGTRYMKSVLESLVGALNDTELGDAYSLERVIYDDDAGSPLDREKLAEYGFAYEPGKRWFYPPALRVQGRLVNDLLLAIPSEYRREPLASPARPAGKRAFEARLRETLDALGADLVVLDGLLVILDELVRPGAPYCRRIVNIHPGITRADSPYERRGAYATLDALFGARGQKVVDWKTGRTVPVEPLRMTGASFHYVDNGVDSGEVIHDVLNTEIDPDDTILELRWNNFNRSLFPALHEGLAIMAGLDARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U92</accession>
    <name>Q63U92_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2010-09" db="PDB data bank">
            <title>Crystal structure of a putative aminotransferase (BPSL1724) from Burkholderia pseudomallei K96243 at 2.60 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS)</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108324.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3P1T">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A/B/C/D=1-336"/>
    </dbReference>
    <dbReference type="PDBsum" id="3P1T"/>
    <dbReference type="SMR" id="Q63U92"/>
    <dbReference type="STRING" id="272560.BPSL1724"/>
    <dbReference type="DNASU" id="3092858"/>
    <dbReference type="EnsemblBacteria" id="CAH35723">
        <property type="protein sequence ID" value="CAH35723"/>
        <property type="gene ID" value="BPSL1724"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1724"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3817"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPPLNDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3P1T"/>
        </source>
    </evidence>
    <sequence length="336" mass="37184" checksum="B40C4DA37E749753" modified="2004-10-25" version="1">MSVGEAMDTEVRAAAQAVCLAFNENPEAVEPRVQAAIAAAAARINRYPFDAEPRVMRKLAEHFSCPEDNLMLVRGIDECFDRISAEFSSMRFVTAWPGFDGYRARIAVSGLRHFEIGLTDDLLLDPNDLAQVSRDDCVVLANPSNPTGQALSAGELDQLRQRAGKLLIDETYVDYSSFRARGLAYGENELVFRSFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVGTLDLHALEAALDNDRAREAHIAKTLAQRRRVADALRGLGYRVASSEANFVLVENAAGERTLRFLRERGIQVKDAGQFGLHHHIRISIGREEDNDRLLAALAEYSDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UJ5</accession>
    <name>Q63UJ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative copper-related ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539779.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108221.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1605"/>
    <dbReference type="EnsemblBacteria" id="CAH35605">
        <property type="protein sequence ID" value="CAH35605"/>
        <property type="gene ID" value="BPSL1605"/>
    </dbReference>
    <dbReference type="GeneID" id="56529327"/>
    <dbReference type="KEGG" id="bps:BPSL1605"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3664"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="32851" checksum="7D8C78511EA8FD9D" modified="2004-10-25" version="1">MIELTGVVKTFGPVRAVDGIDLAIAPGELFGLIGRNGAGKSTLFQLMLGLLAADAGNVRIDGVSARDPRFRAVRRTLGYLPENVVLYDNLTGLETLRFFARLKGVDAAACAPLLDEVGLDHAAARKVRGYSKGMKQRLGFAQALLGAPRLLFLDEPTNGLDPAGIRAFYRILHERRRAGTTIVITSHILAEIQQRVDRLAIVRAGRLQAVGSVDALRGETNLPLTIELVVPDDDTREIEAALRRAPFGEPTVRDRRIAFACPRDAKMAALAALAPLGARIVDLRIHEPSLEDMFLGYAGCEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US6</accession>
    <name>Q63US6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108140.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1520"/>
    <dbReference type="EnsemblBacteria" id="CAH35521">
        <property type="protein sequence ID" value="CAH35521"/>
        <property type="gene ID" value="BPSL1520"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1520"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1708"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020980">
        <property type="entry name" value="Membrane_HflK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12221">
        <property type="entry name" value="HflK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="8">
        <location>
            <begin position="102"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="449" mass="48455" checksum="C17CC4300719328A" modified="2004-10-25" version="1">MNDYNERSTWRRMRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGGNNGFRPDNGRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRLGQYKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTRDADIVDVRFAVQYRVGSPTDYLFHAVDPERSVSQAAQATVREIVGARRADEMLAQDRDALRDALSKAIQRDLDRYRTGLVVTGVTVQSVSPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKSYAERVVAQAEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVLYLPLDKIVEAGRQRAAEAASAGVAPPASGAQAPAPASAAAAASAPRAAAPAAASPASGSDSRSREALRSRSRTDDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UU0</accession>
    <name>Q63UU0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol_B_exo2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191371.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108126.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1506"/>
    <dbReference type="EnsemblBacteria" id="CAH35507">
        <property type="protein sequence ID" value="CAH35507"/>
        <property type="gene ID" value="BPSL1506"/>
    </dbReference>
    <dbReference type="GeneID" id="56595756"/>
    <dbReference type="KEGG" id="bps:BPSL1506"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3542"/>
    <dbReference type="eggNOG" id="COG3298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VLHYRGL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019288">
        <property type="entry name" value="3'-5'_exonuclease_PolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10108">
        <property type="entry name" value="DNA_pol_B_exo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_B_exo2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="29396" checksum="C915FB3A266E77AD" modified="2004-10-25" version="1">MTPILVFDIETIPDVDGIRRLEDLPADLADAEVAEHAFAARREKTGSDFLPHHLQRIAAISCVFRDNNGFRVRSLGTPDDPEATLIQSFYRVIEKYTPQLVSWNGGGFDLPVLHYRALVHGVAAPRYWDMGEDDRDFKWNNYLSRYHTRHLDLMDLLALYQPRASAPLDALAKLCGFPGKLGMDGSQVWTAFREGRIEEIRNYCETDVVNTYLLYCRFQQMRGGLSPAEYTEEIALVKNTLVQEPAPHWAEYLAAFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD1</accession>
    <name>Q63VD1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521850.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107935.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1311"/>
    <dbReference type="EnsemblBacteria" id="CAH35308">
        <property type="protein sequence ID" value="CAH35308"/>
        <property type="gene ID" value="BPSL1311"/>
    </dbReference>
    <dbReference type="GeneID" id="56526528"/>
    <dbReference type="KEGG" id="bps:BPSL1311"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.181"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PITIMVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="17993" checksum="556E9BC8FF12B693" modified="2004-10-25" version="1">MAYSLDELDLRILAALQADASLSNLALAERALSSPPTCMRRVRKLTEAGIIERRIAVLDRGRIGTSVTAIIEVGLDRQTAEDYDAFEAYACAQPEVTQCYRVSPGPDFVIVADLADMAAYDEFARRLFTHASNVRNVRTFFSTHRAKFEANAPVRATPGKRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VK1</accession>
    <name>Q63VK1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186021.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107865.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1244"/>
    <dbReference type="EnsemblBacteria" id="CAH35238">
        <property type="protein sequence ID" value="CAH35238"/>
        <property type="gene ID" value="BPSL1244"/>
    </dbReference>
    <dbReference type="GeneID" id="56595178"/>
    <dbReference type="KEGG" id="bps:BPSL1244"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.281"/>
    <dbReference type="eggNOG" id="COG3235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYIFCSG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="224" mass="23609" checksum="73A8172EE9DF0201" modified="2004-10-25" version="1">MGFLYTPLPFWIAVGGWIAAVGLLVLALWKRPFGRLQDATLQHVWLALVTTITVLWASNAWLDDGLVMHLLGATLLVTLFDWTLALVGMAAVIGVAAIVFDATWQGVGLTYLVYGALPVAVSTLLQRAALAWLPHNLPALIVGQGFVSPAIAVGIVAAAAAGVQIAIAEGTLVVVPSGYALNALLLALGEAWFTGMATALIAVYRPAWVTTSDVRRYRLGGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W57</accession>
    <name>Q63W57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisJ</name>
        <name evidence="7" type="ordered locus">BPSL1033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198602.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107659.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1033"/>
    <dbReference type="EnsemblBacteria" id="CAH35028">
        <property type="protein sequence ID" value="CAH35028"/>
        <property type="gene ID" value="BPSL1033"/>
    </dbReference>
    <dbReference type="GeneID" id="56596157"/>
    <dbReference type="KEGG" id="bps:BPSL1033"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.535"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FSEEPYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005768">
        <property type="entry name" value="Lys_Arg_Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01096">
        <property type="entry name" value="3A0103s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266826" evidence="5">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="28084" checksum="8B920BCFE3F445C9" modified="2004-10-25" version="1">MKKLALCAALALAAGGAFAKEWKTVRIGVDASYPPFESTAPSGEIVGFDVDLAKEVCKRINAKCTWTPQDLDGIIPALKAKKFDVIVSSLTVTDKRREQIDFSDKLYDAPARMIAKAGSPLAPSVESLKGKRVGVEQGSTQETFAKAHWEPKGVTIVSYQNQDQVYADLGSGRLDATLQDELQADYGFLRTPRGKGFAWAGPAVKDPRTLGDGTAMGLRKEDADLKDAINRALASMHKDGTYDRLSRKYFPYSVYSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W93</accession>
    <name>Q63W93_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204931.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107623.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0995"/>
    <dbReference type="EnsemblBacteria" id="CAH34991">
        <property type="protein sequence ID" value="CAH34991"/>
        <property type="gene ID" value="BPSL0995"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0995"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.577"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTAKQWP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1372" mass="141507" checksum="55F01C81F467FA86" modified="2004-10-25" version="1">MTKDVSEPTPPHAPDGGAPGGPREPAPKPRRSPGARALVALAWTALALVVLVAATAGALLAAATTERGTQLAWHAAVKLLGGRLAGTLEGGALATGVRIRQLAWTSPDGSGTEVRIDRLAGRWALTRAPWRLSIASLRAGTIDVRVAPSPPSPTVMPKDLRLPLQLAVDDLRFDRLRIHEAGSTTELDNLIFHGASDGRRHDATLERLDTPFGALTANARLDGVRPFAIDGSATYAGKLSGESVDARARVSGSLEALVAELDASGMKLAGRAHIEAAPFAAVPLTRASLAFDHVNPRALSPGAPVADLAVRAQLEPAAPEPNAPKAFVVTGPVSIVNAKPGALGDALLPLVDAHANVRLDAHAQRIDALAVRTIRDGSVTGGGALVNGRGRFDLKVANLDLNAFVAALRPMRLAGPVGVALEPGAQTIDFDLADAKLALGAKAKIKLDAKQTTIADARVSAGNGRIELAGALRHDARSTYDLKAKLVDFDPLALAAAGTPSGARAGSAAGGGKGAGAAKGAKLTQTAAGSRRAGANAARAGGPRAGTARVNGTLAATGALAPGFSTKAQFKLGDSVYDGLPMTGEGTVQMAGARILPSNANLSVAGNQVALRGSFGASGDRLRFNVDAPQLERLGFGLAGLVRANGELTGSFAHPNVVADYTATGVVFGSNRIGSAQGRADIRDGAKGALVFTADANDIALGAISLKTLSAHLNGTRAKHAFDASAVGVAEGRVINLAVAANGGVVETRGAMRWDGTVTRLSNRGTPSISLDTPLAISAGAQRVTLGAAKLSVEGATLDLKSFTLERGKLRTAGSITNLSVARALEIRAELTGKRSPLRTDLILDGDWDMTLGDTAAGHAQIKRRSGDVTIETGRGVAALGITELSARAAFAPGNRLDATVRARATRIGTLDANVAVPFALRDGVFGVAEDGPLTGRIDADVPALKSTGGLFGPSYLLDGRAALKLTVAGTPAKPKLSGTLTGDDLSATLVDQGVQLKDGIVRVRLTENLVEFQQVEFHGGDGTLRAIGRVRLDGSEPDLTASIVADKLELFAAPDRKLSLSGKAVVENDAPRGGIAINGKFTVDRALFDLPEEAAPHLSDDVVIVRPGSLERGATKTGTAIAKPAPATEKPAPSLAPRANIDIGLGRDFRFKGHGADLRLAGTVTVMSAPGVPLRAVGNVRVTEGSTYTSFGRKLAIENGFFTFNGPVSNPGINILAMRRNQEVEAGVQVTGTVQSPSVKLVSEPNVNDNEKLSWLLFGHGTDQGNNLGQQNAMTTALALLGSATGKRVAQTVGLDEVSVGRSDVGLTDPQVVLVSKAINERFVLGYEQGLQSASNAFKATINLTRFWAISAYGGTFQGVDLNYTRRFDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X01</accession>
    <name>Q63X01_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526200.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107365.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34731">
        <property type="protein sequence ID" value="CAH34731"/>
        <property type="gene ID" value="BPSL0739"/>
    </dbReference>
    <dbReference type="GeneID" id="56527054"/>
    <dbReference type="KEGG" id="bps:BPSL0739"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.810"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="104" mass="11925" checksum="DC72D080EA5D90C8" modified="2004-10-25" version="1">MARGRIIPGAYAISETTSARLRQEYPGLDHWSISEFQLAWGNYARELRGDAGMTFDRDEVFLVYLHIVRKDRTFSFAGDRGMPGTWEAYAQEKPWETDAPLPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X20</accession>
    <name>Q63X20_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative alcohol dehydrogenase cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL0720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="8">Binds 3 heme c groups covalently per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Binds 3 heme groups per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107346.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0720"/>
    <dbReference type="EnsemblBacteria" id="CAH34712">
        <property type="protein sequence ID" value="CAH34712"/>
        <property type="gene ID" value="BPSL0720"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0720"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.788"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFCARCH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014353">
        <property type="entry name" value="Membr-bd_ADH_cyt_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000018">
        <property type="entry name" value="Mb_ADH_cyt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266846" evidence="12">
        <location>
            <begin position="33"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="84"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="230"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="369"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000018-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000018-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="479" mass="49856" checksum="F481A89559FAAF4C" modified="2004-10-25" version="1">MSPMALIAARGPRLRFSAAAATAATASALVMAALLGGCERDAGGAGGARAAAAPPPASAASAAQAAGARAAARIASDASRADPAAIARGRYLARAGDCAACHDAADHTPYAGGQPVNSPFGPIYASNITPDPDAGIGRYSLRQFADALRLGKAADGRRLYPAMPYPSFAKLDDSDVAALYAYFMHGVQPSDKRAPATRLPFPFNQRWGLAIWSALFGNRERFVPNPQRPAAWNRGAYLVQGLGHCGACHTPRGPAYDERGYDERSAAYLTGGVNDHWFAPNLTGAPLDGLGRWSERDIAAFLRTGHARHSAAFASMAPVVEASTALLSDDDLHAIAVYLKSLPAQRTPAAALVPGRARQPPARAADDGTQQRPGAGVYFAFCARCHGADGAGTPDRGPALAGNSLVLAPDPTSAIRIVVEGSAEPRVAGRDARRMPGMRGRLTSTEIAQVVSFVRGAWGNQAAPVSDREVESLRSAVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XC7</accession>
    <name>Q63XC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fis family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936335.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107238.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0609"/>
    <dbReference type="EnsemblBacteria" id="CAH34602">
        <property type="protein sequence ID" value="CAH34602"/>
        <property type="gene ID" value="BPSL0609"/>
    </dbReference>
    <dbReference type="GeneID" id="56527181"/>
    <dbReference type="KEGG" id="bps:BPSL0609"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1018"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYRLHIV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045343">
        <property type="entry name" value="VpsR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20161">
        <property type="entry name" value="VpsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="151"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="462" mass="50643" checksum="0D56C482246EA20E" modified="2004-10-25" version="1">MTTSAIIGGPSRGSIRQRPLIYWTHQPSTLLRKELARRDWKISVVTSANQVRTTAGEVTGGILDLSAVSIDEMNAVAAVCASLRNVAWVALVEAQQANVPNVRTLLRDYCFDYITLPASHQRIADAVGHAYGMECLFAPSTAPIASADQGMIGTCDAMLQLFDTVRRIARTDAPVLVSGETGTGKELTAAAIHQHSARRAGPFVAVNCGAIPPHLLQSELFGYERGAFTGASTRKIGHVESANGGTLLLDEIGDLPLESQASLLRFLQERTIHRLGGSEPVPVDVRIVSATHVDLRGAMNEGRFRADLYHRLCVLRVDQPPLRARGKDIELLARHMLERFRADARHRVRGFSTDAISALYKHDWPGNVRELINRVRRALVMAEGRLITAHDLELDHCTEVAPLSVAAIRKSIEREVIELALLRNRGRLAGTARELGISRATLYRWMEAYGIERPRSAASSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XD0</accession>
    <name>Q63XD0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526105.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107235.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0606"/>
    <dbReference type="EnsemblBacteria" id="CAH34599">
        <property type="protein sequence ID" value="CAH34599"/>
        <property type="gene ID" value="BPSL0606"/>
    </dbReference>
    <dbReference type="GeneID" id="56527184"/>
    <dbReference type="KEGG" id="bps:BPSL0606"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1024"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIEVVAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="216" mass="23486" checksum="40297C8BB8B18FFF" modified="2004-10-25" version="1">MDWTCCEFRHLSSNELYMILRTRNAVLVVEDAHTHLDIDGKDEFAIHVFATDKRGEQPAIAAYARLLPGDDIDPETTIDKILTSAAHRDDRTIDALIEHVLAAAHARWPDAPVRVQAPAPREGFYNRFGFRKVDGPYLEHGAPYVGMLRAASAPSKAVRNLLDLVGNATGANPGTSAGAVPASAARKPRKANAESTTEGERYAFAGRLPADSGMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XF3</accession>
    <name>Q63XF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936297.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107212.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0584"/>
    <dbReference type="EnsemblBacteria" id="CAH34576">
        <property type="protein sequence ID" value="CAH34576"/>
        <property type="gene ID" value="BPSL0584"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0584"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1058"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266409" evidence="2">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="462" mass="48429" checksum="69D4DF5EC20150B0" modified="2004-10-25" version="1">MKTFVAAILVADLMIAGQAAADAIQPNQTAATVKYADVVQLFPNALYPSKHGALTTYDGLHLRGNGFDAVNPAANILLIDGNRALQMCVQDKPTAGCTPGFSVAGITGGTELEVNGIPENFKGFRRIAVATTSGAQGLGTAIPSSAPTVTFSPFGAIWPRVAALIVLVASISLVPIVFRRRVPLSGAPAGTMIRQWQLLLVEPDTNTFSLSRLQLVVWTFVALFAWSYLSIARSVIQMTPTFGDIPGSLAGLLGISVGATVSTLTLNVVKGGKAAGPTSPSFSDFISVGGVVAPDRLQYLLWTVVGAIAYVTLTLSLDPARIQQYIELPTGFLTLSGISAAGYLGARIARSAGPIVSRVTAAPDAETQAVTLTVEGTALSKSGKYLIAYSTNNGYGSAVAITASELQLPIVANVEDQDGSPDLYKKLVIVFKPARGNWFGQQSQKGQFSIINPDGQRADWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XG2</accession>
    <name>Q63XG2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107203.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0575"/>
    <dbReference type="EnsemblBacteria" id="CAH34567">
        <property type="protein sequence ID" value="CAH34567"/>
        <property type="gene ID" value="BPSL0575"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0575"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.621"/>
    <dbReference type="eggNOG" id="COG4688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTIAHYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="651" mass="73398" checksum="108A3C729F937C7C" modified="2004-10-25" version="1">MALAALQHVATVRPVASVVRIDPRTDSCIVARRSLIELYKTSQPFGEINWLSSCWDITDALRDKIKGYTARKRALVHFTRHREVGQRIGLPFPEEDDLASVIKAFACRQHVLNGVTAARHMVYIRAWRYIVGAMRGTDIAQVTPATFNSAALAATREKSSSAYTVHGALEAIADMLDELRLTKVPLRWRWVKKKRGKGYGGSKQIRLGQAPDTDRRASDDVVYAVAQLYRIVPKTKWADRICVLLATILVCTGLRLGQVLCLRAEMPAFDEATGEHFIRLVAFKRTDATRKTLLSETVGLLNDVFRELLEITEPVREVARWLDKNPGRVNLPKPDNSDGTVTAARLRTWFGLSTGAFKRRLQTWGFAGAAIPLHELNERLLRDRFDKPVVPGTRGEQLLLKDCLSISFVSAMKQTTAALKHAVRPIGEQHVSDRLRGRQLGDGRSRATIFDRYSLTDSQGNPLSTYTHGFRHKLNDALDKGGAPDVIQAQWFGRANPRDNKAYQYRTHAEMRERARDMLIKGQLNGRFATLLSQVTPECRKEAAESMVQVAHPISGGYCLQNFAQVDCEHCGQCLDECMSFHWVPGETDRQDEVIAIRDTISRKLNVMLDKMSPTERQNDESFSRLRHQQNFVNQILKSMEESKVGEPNKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-24" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XL1</accession>
    <name>Y529_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein BPSL0529</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL0529</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530937.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107154.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XL1"/>
    <dbReference type="SMR" id="Q63XL1"/>
    <dbReference type="STRING" id="272560.BPSL0529"/>
    <dbReference type="EnsemblBacteria" id="CAH34518">
        <property type="protein sequence ID" value="CAH34518"/>
        <property type="gene ID" value="BPSL0529"/>
    </dbReference>
    <dbReference type="GeneID" id="56527225"/>
    <dbReference type="KEGG" id="bps:BPSL0529"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1119"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000107695" description="Nucleotide-binding protein BPSL0529">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <sequence length="297" mass="33195" checksum="5B42CF3973D108B4" modified="2004-10-25" version="1">MRIVLITGISGSGKSVALNALEDAGYYCVDNLPPHVLPELARYLAHEGQNRLAVAIDARSSASLDEMPGLIRALSREHDVRVLFLNASTQALIQRFSETRRRHPLSGSPSHDADVGLLVSLEEAIERERELVAPLAEFGHQIDTSNLRANVLRTWVKRFIEQKNDDLVLMFESFGFKRGVPLDADFMFDVRALPNPYYDHELRPLTGLDQPVVAFLDALPVVHQMLDDIETFLVKWLPHFREDNRSYLTVAIGCTGGQHRSVFLAETLAARLSRQASVIVRHRDAPVAVDASSRLVT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XL7</accession>
    <name>ISPE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">BPSL0523</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195241.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107148.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XL7"/>
    <dbReference type="SMR" id="Q63XL7"/>
    <dbReference type="STRING" id="272560.BPSL0523"/>
    <dbReference type="EnsemblBacteria" id="CAH34512">
        <property type="protein sequence ID" value="CAH34512"/>
        <property type="gene ID" value="BPSL0523"/>
    </dbReference>
    <dbReference type="GeneID" id="56593810"/>
    <dbReference type="KEGG" id="bps:BPSL0523"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1125"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000235074" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="293" mass="31635" checksum="D4468CCD7D15D19B" modified="2004-10-25" version="1">MTDTTRSLRDCLAPAKLNLFLHITGRRPDGYHALQSVFQLLDWGDRLHFTLRDDGKVSRVTDVPGVPEESDLVVRAASLLKAHAGATLGVDIEIDKRLPMGAGLGGGSSDAATTLLALNRLWRLDLPRTTLQSLAVKLGADVPFFVFGKNAFAEGIGEALQAVELPARWFLVVTPRVHVPTAAIFSEKSLTRDSKPITITDFLAQRGIDAGWPDSFGRNDMQPVVTSKYAEVAKVVEWFYNLTPARMTGSGASVFAAFKSKADAEAAQAKLPAGWNSAVAESMSEHPLFAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP4</accession>
    <name>Q63XP4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195336.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107121.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0496"/>
    <dbReference type="EnsemblBacteria" id="CAH34485">
        <property type="protein sequence ID" value="CAH34485"/>
        <property type="gene ID" value="BPSL0496"/>
    </dbReference>
    <dbReference type="GeneID" id="56593861"/>
    <dbReference type="KEGG" id="bps:BPSL0496"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1159"/>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YMKNPRL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="9">
        <location>
            <begin position="41"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="367" mass="38679" checksum="8B5648B36E87D596" modified="2004-10-25" version="1">MLTGNILTAEGWIHGTLEFENGRITTLSGDAADPSNNDAPYILPGFIDLHVHGAGGADVMEGGDAIETIARTHARYGTTSLLATTMTAPRDELMRVVAELGDVARTRTPGGSRVLGVHLEGPYINPGKLGAQPDAAVSAALDEVLKYLSIAPIRVVTLAPEIAGHIEIISEMAARGVRVQLGHSLGTYDDAVAALKHGACGFTHLFNAMSPLHHRNPGIVGAALAHAEYAEIIPDLLHVHPGAIRAALRAIPRLYVVTDSTSATGMPDGEYRLGSQRVTKCLGGVRLADGTLAGSTLTMDQALRNLVSLGLPIADVSSRMSRYAADYLGLADRGRIARGAWADLAVFDRELNLTATFVEGESIVEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP6</accession>
    <name>Q63XP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195334.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107119.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0494"/>
    <dbReference type="EnsemblBacteria" id="CAH34483">
        <property type="protein sequence ID" value="CAH34483"/>
        <property type="gene ID" value="BPSL0494"/>
    </dbReference>
    <dbReference type="GeneID" id="56593859"/>
    <dbReference type="KEGG" id="bps:BPSL0494"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1161"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKQPELC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="307" mass="33221" checksum="51CD045A694DEE10" modified="2004-10-25" version="1">MIDLRRLRYFIVVAEELHFGKAAQRLHLAQPPLTRHISALEGELGLRLFDRSTRSVKLTAEGELFLPHARDVLDAVHRAEIASQRAALGKEGKVALGYTSSVPLCDAFGTLIRNFARSFPDIELSLVEASSAQQGRSIKEGLLDIGIGWKNSFEDYEGCRVKTIAAEPLVVAVSQERALASEASLAVEQLADETFVLFPPGYGSTLDRKAFDLCATAGFTPRRGPSASQMTTMIALVAAGRGVAIVPEAVSTLRKPGVAYVPLTDESALIELVLMWREAGLSLAARSFVEWHKAHVAQRVDGMVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR3</accession>
    <name>Q63XR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526031.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107102.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0477"/>
    <dbReference type="EnsemblBacteria" id="CAH34466">
        <property type="protein sequence ID" value="CAH34466"/>
        <property type="gene ID" value="BPSL0477"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0477"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1178"/>
    <dbReference type="eggNOG" id="ENOG50335BI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RWTHAFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="177" mass="18310" checksum="9CCD8FABC2A0A434" modified="2004-10-25" version="1">MPDLILAYLRNAALFAPAIAFMLFMRALPGGGDAHWRHAALAGALLALPHTAWLLRRRPLHGTALGLNAYLIVSAALPFVSADAARDWGAALGSAAMLGSVLAAHALGLAVAPEAFSGAADPALARARCRKMTVYSGIALAAAFPHRHDPLLGGALPVVALILLHKRLRRGALAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y51</accession>
    <name>Q63Y51_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MutT/NUDIX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537794.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106964.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0337"/>
    <dbReference type="EnsemblBacteria" id="CAH34326">
        <property type="protein sequence ID" value="CAH34326"/>
        <property type="gene ID" value="BPSL0337"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0337"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1343"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HFEASRN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="136" mass="15011" checksum="9B8459CA8CE763DA" modified="2004-10-25" version="1">MQHTEQPRVGCGAAIVRDGRILLIKRKRAPEAGCWGLPGGKVDWLEPVERAVCREIEEELGIALERATLLCVVDHIDAANGEHWVAPVYLAHAFSGEPRVVEPDRHEALGWFALDDLPQPLTHATRVALEQVTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y69</accession>
    <name>Q63Y69_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106946.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0319"/>
    <dbReference type="EnsemblBacteria" id="CAH34308">
        <property type="protein sequence ID" value="CAH34308"/>
        <property type="gene ID" value="BPSL0319"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0319"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.353"/>
    <dbReference type="eggNOG" id="ENOG50326KU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="179" mass="19146" checksum="D46186077DE7EDC8" modified="2004-10-25" version="1">MTYAPAGAGAETFRAWNARRGDSRRVGGCLQRVPEEDSPIGRAPADERTPPASHRAARCMPEAPAPIPGAAMRGPLELAHRAFLPPLKAGRRNATMGASFLGRGIMDGGNTYTKGLYTAKAHTRKTDNGRFQGYVILSRDEGGAPENTLYEVEATSANEAEAFDEAKALAHRILGDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y70</accession>
    <name>Q63Y70_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189988.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106945.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0318"/>
    <dbReference type="EnsemblBacteria" id="CAH34307">
        <property type="protein sequence ID" value="CAH34307"/>
        <property type="gene ID" value="BPSL0318"/>
    </dbReference>
    <dbReference type="GeneID" id="56594646"/>
    <dbReference type="KEGG" id="bps:BPSL0318"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1369"/>
    <dbReference type="eggNOG" id="ENOG5033CJ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CWPWLRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="64" mass="7288" checksum="932C3EBC97DFF070" modified="2004-10-25" version="1">MLRWLLTTFIAVMVLTRAWPWLAKLGVGRLPGDVTLRLGSRVYPFPFMSTLVIMGIVSVIARLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YN8</accession>
    <name>Q63YN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage major tail tube protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524455.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106777.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0149"/>
    <dbReference type="DNASU" id="3092323"/>
    <dbReference type="EnsemblBacteria" id="CAH34136">
        <property type="protein sequence ID" value="CAH34136"/>
        <property type="gene ID" value="BPSL0149"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0149"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1572"/>
    <dbReference type="eggNOG" id="COG3498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TYYKLEV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006498">
        <property type="entry name" value="Tail_tube"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35861:SF2">
        <property type="entry name" value="PTHR35861:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04985">
        <property type="entry name" value="Phage_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01611">
        <property type="entry name" value="tail_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="19030" checksum="33E748A885A110A5" modified="2004-10-25" version="1">MGMPRKLKGFNVFHNGANFVGEVEELNLPKLKRKMEAWQGSGMTGPVKIDYGSEELQLEWTCGGFMVEVLEQYGAVQHDGVLLRFAGGYRREDSKKHDQIEVVVKGRHEEIDMGTAKAKEDTKFKITTNASYYKLTVNGRDLIELDFVNAVEKINGMDLASDLRRAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YS0</accession>
    <name>Q63YS0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL0118</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525850.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106745.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0118"/>
    <dbReference type="EnsemblBacteria" id="CAH34104">
        <property type="protein sequence ID" value="CAH34104"/>
        <property type="gene ID" value="BPSL0118"/>
    </dbReference>
    <dbReference type="GeneID" id="56527595"/>
    <dbReference type="KEGG" id="bps:BPSL0118"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1605"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAQPKQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13342">
        <property type="entry name" value="Toprim_Crpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="813"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="869" mass="96946" checksum="32ED56B71AA5E152" modified="2004-10-25" version="1">MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDMDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDHLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKGEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKPAAAKKTAARSSAAADDAAADSGEKAEKKAAPARKTAARKTPARKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YW0</accession>
    <name>Q63YW0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106705.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0079"/>
    <dbReference type="EnsemblBacteria" id="CAH34063">
        <property type="protein sequence ID" value="CAH34063"/>
        <property type="gene ID" value="BPSL0079"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0079"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.89"/>
    <dbReference type="eggNOG" id="ENOG5032R4Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHWLHYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="17495" checksum="58F3AAD1186A63A8" modified="2004-10-25" version="1">MVVFLAAVELHNLAMPTHEEKAAFTERLKFALLRSPEKVTGATELALHFNLRHHGEHPVSPQTAHKWLTGRTIPTPDKLHTLAEWLRVDLHWLHYGPPPSAARTTPQPLPRDEKYPPTPETIELASKIEALSPHHRYLVQELIEQFYGDTSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV3</accession>
    <name>Q63HV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112319.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63HV3"/>
    <dbReference type="STRING" id="272560.BPSS2317"/>
    <dbReference type="DNASU" id="3096972"/>
    <dbReference type="EnsemblBacteria" id="CAH39803">
        <property type="protein sequence ID" value="CAH39803"/>
        <property type="gene ID" value="BPSS2317"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2317"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6774"/>
    <dbReference type="eggNOG" id="COG5424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WCWHTSS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="254" mass="28818" checksum="5F0B6804AA3AC262" modified="2004-10-25" version="1">MTLSKERKLHIPFERDGDLMDIGSYPHWLQDVVGTVRAARDRVRFHEVFSLMRDGRLAPRQLAAFFVNGWPVVEQFPKYMSMNLLKANGTNSSGEEKARRYLIRNIRVELNHVEHWVNWAEASGVPRRQLTDGDSPPAALALSHWCWKSSSADTLAASIAATNYAIEGVTGEWSADLCRSDVYEMGFPEAVRGRAMRWLRLHSSYDDKHPWEALDIVATILGQSPSTEQVRDVAAGIERSFRYFEMSLSCCLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HX0</accession>
    <name>Q63HX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS2299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112302.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2299"/>
    <dbReference type="EnsemblBacteria" id="CAH39785">
        <property type="protein sequence ID" value="CAH39785"/>
        <property type="gene ID" value="BPSS2299"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2299"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6749"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMHNVIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="958" mass="106526" checksum="DA59DD7758323EFE" modified="2004-10-25" version="1" fragment="single">TTTCYMCACRCGIRVHLRNGEVRYIDGNPDHPLNQGVICAKGASGIMKQYSPARLTQPLMRKAGAERGSAQFEPVSWDVAFSVLEQRLAHLRATDPKRFALFTGRDQMQALTGLFAKQYGTPNYAAHGGFCSANMAAGMIYTVGGSFWEFGGPDLDRAKLFFMIGTAEDHHSNPLKIAISKFKRAGGRFVAINPVRTGYAAIADEWVPIRPGTDGALFMAMIRELIETGGYDRDFVTRYTNAAELLDMRAEADTFGLFVRDASRPERNPLFPQNHLWWDLGSGRAVAHHTRGATPALDGRYALDDGTPVAPSFALLRERVAECTPQWAERITGIPAATIRRLAHEMADVARDHKITLPIRWTDAWGETHDTVTGNPVAFHAMRGLAAHSNGFQSIRALAVLMSLLGTIDRPGGFRHKSPYPRAVPPSAKPPNGPDAVRPNTPLAAGPLGWPAAPEDLFVDEQGGPVRIDKAFSWEYPLAVHGLMHSVITNAWRGDPYPIDTLMIFMANMAWNSSMNTVEVRRMLADRHDNGDYKIPFIVVCDAFQSEMTAFADLILPDTTYLERHDAMSMLDRPISEFDGPVDSVRIPVVPPTGECKPFQEVLIELASRLKLPAFTNADGTRKFRDYPDFVINYQTAPDSGVGFLIGWRGEDGGDALVGAPNPRQWDEYEKHGCVFHYTLPDTLQYMRGCNGPYLKWAVEKGFRKYDAPIVIHLYSDVLQKFRLAAQGRTRGRQPPEHLRARIARHFDPLPFWYEPLELGATDLQRYPLAAVTQRPMAMYHSWDSQNAWLRQIHGENALFVNPKVARDAGIDDGGWIYVESQWGKVRCRARYSEVVEPGTVWTWNAIGKAAGAWNLGPDANESQRAFLLNHVITDELPGEGAHAPRISNSDPITGQAAWYDVRVRIYPAEADADHTLPQFAPMPALPGVTGAVRRIVQTYFAGRGEFAARLRDAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I96</accession>
    <name>Q63I96_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome P460</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530718.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112176.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2174"/>
    <dbReference type="EnsemblBacteria" id="CAH39659">
        <property type="protein sequence ID" value="CAH39659"/>
        <property type="gene ID" value="BPSS2174"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2174"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5753"/>
    <dbReference type="eggNOG" id="ENOG5030GRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDYVFTR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032033">
        <property type="entry name" value="Cytochrome_P460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038142">
        <property type="entry name" value="Cytochrome_P460_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16694">
        <property type="entry name" value="Cytochrome_P460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266292" evidence="1">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_P460" evidence="2">
        <location>
            <begin position="42"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="18224" checksum="0D1185678BE0EC60" modified="2004-10-25" version="1">MQSLRFFRPAAACALLLVAAHGGAFADAPGRAASPIYGVTIPDGYRKWQMIAPAEEAAPLDELRVVLGNPAAVEAIERATLPFPDGAVLVKLAYKRKRSDEFESATVPGAPTTVQVMVKDSRRYASTGGWGFGRFVNGMPVDAAQHQTCFACHQARVQARDFVFTRFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF6</accession>
    <name>Q63IF6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS2117A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536572.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112116.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39598">
        <property type="protein sequence ID" value="CAH39598"/>
        <property type="gene ID" value="BPSS2117A"/>
    </dbReference>
    <dbReference type="GeneID" id="56598140"/>
    <dbReference type="KEGG" id="bps:BPSS2117A"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5665"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TTVVQFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="101" mass="11172" checksum="60D0FF739CB39980" modified="2004-10-25" version="1">MITVITSFQLPAPLAREEARSLFLRAAPKHQGVVGLCANTMSCRKAEGRVYLWNARAQAETMYTDAWKASAYETFGTFPSITYFESPAVVDNATNAIFSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG5</accession>
    <name>Q63IG5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190377.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112107.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2108"/>
    <dbReference type="EnsemblBacteria" id="CAH39588">
        <property type="protein sequence ID" value="CAH39588"/>
        <property type="gene ID" value="BPSS2108"/>
    </dbReference>
    <dbReference type="GeneID" id="56598129"/>
    <dbReference type="KEGG" id="bps:BPSS2108"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5653"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KFIAFSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="133" mass="14397" checksum="910E2B5F5A602EDD" modified="2004-10-25" version="1">MKSRSSLYIFLGFFLAGMGGCGTGATSPASTPTVAQATLDSARAAYDAGDYRRTIALLGGHAREIDGADVNTQVAAHKLLAFSYCLTRRTTQCRAEFSRILDLNPRFDLSPAEKGHPIWGPAFEYARRKHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63II9</accession>
    <name>Q63II9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524829.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112083.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2082"/>
    <dbReference type="EnsemblBacteria" id="CAH39562">
        <property type="protein sequence ID" value="CAH39562"/>
        <property type="gene ID" value="BPSS2082"/>
    </dbReference>
    <dbReference type="GeneID" id="56531819"/>
    <dbReference type="KEGG" id="bps:BPSS2082"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5625"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYPLTLG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="283" mass="31642" checksum="AAA3505F7EEC92E3" modified="2004-10-25" version="1">MFPTPIAQASRPAQWLYRLTVTVALVLWLLPLLGIALTSIRGPADIFAGNYWGWPTQWQIVENYRAIFSETPLAHYLVNTCLITIPSVIGAVALSCMAGFALGIYRFRLNLPVFFLFLAGNFVPFQILMIPVRLMSLRLGLYNSVPGLVLFHVAFNTGFCTFFMRNFIRELPRELIEAARMDGASEFQIFYKVVLPLVRPAMAAISVLVFTFVWNDYFWATVLVQGDHAMPITAGLKTLSGIWVAQWHLVAAGSLVAALPPVLIFFLRQRYFIAGLTMGATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IQ3</accession>
    <name>Q63IQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wecB</name>
        <name evidence="3" type="ordered locus">BPSS2016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524905.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112019.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2016"/>
    <dbReference type="EnsemblBacteria" id="CAH39494">
        <property type="protein sequence ID" value="CAH39494"/>
        <property type="gene ID" value="BPSS2016"/>
    </dbReference>
    <dbReference type="GeneID" id="56531866"/>
    <dbReference type="KEGG" id="bps:BPSS2016"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5538"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYNTERP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="404" mass="44300" checksum="74B4C7370B4113E7" modified="2004-10-25" version="1">MKKILLAFGTRPEAIKMAPLVRMLQTRADVDARVCVTAQHRQMLDQVLALFDIAPAYDLNVMRQSQTLADVTTGILQTIGAVFDDFDPDIVLVHGDTTTTLAVSLAAFYRYLPIGHVEAGLRSGDIWSPWPEELNRRVTDAVSSWHFAPTERAQHNLFSEGVPTQGVVLTGNTVIDALQDVKRMLDADAPLAREIAAQFPFLGHDERVVLITGHRRESFGEPFAHFCDALRTLARRYPGVRFVYPLHLNPNVQGPAHALLDGLPNVHLIAPQEYLSFVFLMSRAHFIITDSGGIQEEGPALGKPVLVTRDTTERPEAIQAGTARLVGTDTERIVGEASRLLDDDDAYDEMSRATNPYGDGHASERIAHALLNMPHAADTARFPLAAIEAPCNALALGLRALRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW8</accession>
    <name>Q63IW8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">F-type ATPase subunit c</fullName>
            <shortName evidence="12">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">atpE</name>
        <name evidence="14" type="ordered locus">BPSS1948</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187193.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111954.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1948"/>
    <dbReference type="EnsemblBacteria" id="CAH39426">
        <property type="protein sequence ID" value="CAH39426"/>
        <property type="gene ID" value="BPSS1948"/>
    </dbReference>
    <dbReference type="GeneID" id="60550541"/>
    <dbReference type="GeneID" id="66549185"/>
    <dbReference type="KEGG" id="bps:BPSS1948"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5438"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ALIFRQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="13">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="12">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH39426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="82" mass="8350" checksum="C7742216ED0ABAB5" modified="2004-10-25" version="1">MNNLIEVVSIAAAALAVSFGAIGPALAEGRAVGAAMDAIARQPDASGTVSRTLFVGLAMIETMAIYCLVVALLLLFANPFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IY0</accession>
    <name>Q63IY0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188537.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111942.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1936"/>
    <dbReference type="EnsemblBacteria" id="CAH39414">
        <property type="protein sequence ID" value="CAH39414"/>
        <property type="gene ID" value="BPSS1936"/>
    </dbReference>
    <dbReference type="GeneID" id="56596871"/>
    <dbReference type="KEGG" id="bps:BPSS1936"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6294"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGTHRTQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="508" mass="55254" checksum="0144E156DCDE2329" modified="2004-10-25" version="1">MTMRNDARHDERHQRRRGIARRAARHAAALALCAAVSGCLSLAPDYARKPPPVPAAYPAYPGEPGAGSRTLEQLGWRAYFVDPRLQALIETALANNRDLRIAAQRVEQARAAYGIRRADQYPTIAANAAYLRFREPGGLLLPSPIIGELYSASLSEVQWEIDFWGRVRSLKAAALDTFLASDASRRAVTVSLIGQVADAYLALCAYDERLALTNETIASRRDSLRIFRRRYEEGAISKLDLTQSEILLQQAQTLGSQLQQARDVQQHALDLLVGTNAAARTPASLDDASIAPDLAPGLPSELLANRPDVVAAEYQLRAAHANIGAARAAFFPRIALTSSIGTGSTELHNLFASGTAAWNFIPNLSVPIFDAGRNIGNLKLANARRDEALAQYEKTIQTAFRDVADALAARHWLADQVRIAQETLATQAERARLAKLRYDSGAARFLEVLDAQRDLLNAQQQLVQTRRALLASRVALYAALGGRLDEPARDGAAPRPSPEPSAKQGPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J04</accession>
    <name>Q63J04_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase for insertion sequence element IS1001</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tnpA</name>
        <name evidence="4" type="ordered locus">BPSS1912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538232.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111918.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39390">
        <property type="protein sequence ID" value="CAH39390"/>
        <property type="gene ID" value="BPSS1912"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1912"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5384"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPVHDHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="3">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="157"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="406" mass="47507" checksum="B1051F190F2C9A3E" modified="2004-10-25" version="1">MLDRKALQALGCWTGYRLERVEWPQGDSRTLSLYLKPVSQIMYCEQCGARCQQIHETTVRRVRDLPLFEYRVVLHVPRRRVWCERCGAARLEKLDWLGRYQRVTERFAKACEKLLQAASVQAVAAFYDLGWHTVKSIDKMRLRARVAEPDWSTIRYLAMDEFALHKGHRYATVVVDPIGRQVLWVGPGRSRETARAFFEQLPEGVAERIEAVAIDMTTAYELEIKEQCPQAEIVFDLYHVVAKYGREVIDRVRVDQANQLRHDKPARKVLKSSRWLLLRNRHNLKPEQAVHLKELLAANQSLLCVYVLRDELKRLWFYRKPACAEKAWGQWFEQAQQSGIAALQKFAQRLQGYWHGIVARCRHPLNTSVVEGINNTIKVIKRRAYGYRDEQYFFLKIRAAFPGIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J26</accession>
    <name>Q63J26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cat operon LysR-family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529133.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111896.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1890"/>
    <dbReference type="EnsemblBacteria" id="CAH39368">
        <property type="protein sequence ID" value="CAH39368"/>
        <property type="gene ID" value="BPSS1890"/>
    </dbReference>
    <dbReference type="GeneID" id="56529692"/>
    <dbReference type="KEGG" id="bps:BPSS1890"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5356"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PNIMFEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="295" mass="32293" checksum="68282633A229C68B" modified="2004-10-25" version="1">MELRQLRYFIAVAEEMNITRAAQRLHMTQPPLSRQLQLIEDEIGLPLFERGARPLKLTDAGRVLYAQARRVLEQADELAPLTRRLAQAAERIVIGFVPSTLYGALPEVIRAFREAAPAVELSLIEMFTLEQLGALKGGRIDIGFGRLRFDDDRLVREVLVEERLIAALPDGHPLAAPDASISLADIAGQTLIVYPSTPRPSFADQQLSALRDGGLAPAAVHEVRELQTALGLVAAQVGVSLVPESVEGVRVKGVAYRRLPEPVATSPIILSRRLHDESRATALFCSLARELMAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J45</accession>
    <name>Q63J45_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190643.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111877.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1872"/>
    <dbReference type="EnsemblBacteria" id="CAH39349">
        <property type="protein sequence ID" value="CAH39349"/>
        <property type="gene ID" value="BPSS1872"/>
    </dbReference>
    <dbReference type="GeneID" id="56598282"/>
    <dbReference type="KEGG" id="bps:BPSS1872"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5334"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IDDCWNR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="95"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="244" mass="26929" checksum="CC36AC0C3DA66BF8" modified="2004-10-25" version="1">MERDVVERPRIAFDIDACWNRIGTRGDRSCERLDTYRRCLNCPVFERHAALLLDRPLTDADLADAARVAAERAPGANAPASKASAAARDGDADAVHSALAFRVADEWLALPIRVLREITDTRAIHPLPHRRNRAVLGIVNVRGMLRVAVSLAELLSLDARADRAAPRMSFTRMLVVAHRGDPVVFPVDEVEGVLRFASADWMPVPATVARTGAVHSRGVFAWRGKSIGLLDEDRLFDSLTRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J94</accession>
    <name>Q63J94_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544598.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111828.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1824"/>
    <dbReference type="EnsemblBacteria" id="CAH39300">
        <property type="protein sequence ID" value="CAH39300"/>
        <property type="gene ID" value="BPSS1824"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1824"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5271"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPDQTTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="255" mass="27758" checksum="683D87AFBD11A18F" modified="2004-10-25" version="1">MTRLAAPSLSLRRYGAVQASDVHDFHQIVLGVDGAMTMTVDGVDERIDRRCAWLIPAGARHDYAGLADNSQLVLDLPPGSLAVPERLFERARTMAIDPGLTTLVGELASRIARGPLADAASARRLHWQAAARLCGALVGELGGAPSQPAVGLDFARIDGWLRAHLAQPLRIADLAAHCGFGMRRFHQLFCEAFGETPHRYLQRLRLDAAVMLLGDPKHSLTDIASEVGFADQSAFTHAFTKRFGLAPGRWRSDRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JF2</accession>
    <name>EX7S_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="1">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseB</name>
        <name type="ordered locus">BPSS1764</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190549.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111770.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JF2"/>
    <dbReference type="SMR" id="Q63JF2"/>
    <dbReference type="STRING" id="272560.BPSS1764"/>
    <dbReference type="EnsemblBacteria" id="CAH39239">
        <property type="protein sequence ID" value="CAH39239"/>
        <property type="gene ID" value="BPSS1764"/>
    </dbReference>
    <dbReference type="GeneID" id="56598190"/>
    <dbReference type="KEGG" id="bps:BPSS1764"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5195"/>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDMLKPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000206932" description="Exodeoxyribonuclease 7 small subunit">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="97" mass="9967" checksum="010EDBAEC740BB4B" modified="2004-10-25" version="1">MAKTATPGACASDPGSGPLPENYEMALAELEALVARMEGGTLSLEDSLAAYRRGAALVAFCQQQLEKAEQQVRVLDGASLKPLSAGTAAADGEDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JM7</accession>
    <name>Q63JM7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540506.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111695.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1690"/>
    <dbReference type="EnsemblBacteria" id="CAH39163">
        <property type="protein sequence ID" value="CAH39163"/>
        <property type="gene ID" value="BPSS1690"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1690"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5102"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PKGVEHC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="3">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="126" mass="14068" checksum="AB12FF99F80E1D54" modified="2004-10-25" version="1">MFQAGIGVNFEAALRDVSEYWSPRVVGRVNDQYVKVAKLKGEFTWHKHADEDEMFYVVYGRLRIQFEGRDDVVLNPGDFCIVPKNTMHNPVAEAECGIALIETVTTRHTGDTPSPLAKSIDAQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JN8</accession>
    <name>Q63JN8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative porin related exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525210.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111684.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1679"/>
    <dbReference type="EnsemblBacteria" id="CAH39152">
        <property type="protein sequence ID" value="CAH39152"/>
        <property type="gene ID" value="BPSS1679"/>
    </dbReference>
    <dbReference type="GeneID" id="56529911"/>
    <dbReference type="KEGG" id="bps:BPSS1679"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5084"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDKTKNS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266096" evidence="7">
        <location>
            <begin position="23"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="12"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="384" mass="40166" checksum="A6B921322A72A000" modified="2004-10-25" version="1">MKKLALSTLSLALLGAAGAAQAQSSVTLYGVIDTSITYVHGNDGKANNAWLMGSGNLQGSRWGLKGTEDLGAGLKAIFQLENGFNSNDGTLGQGKRMFGRQAFVGLQHDQYGTLTLGRQYDPLVDLVQPVTADNYFGSLFATPGDVDNNDNSLRVNNTVKYTSPVFAGFQFEALYGFSGIAGSPGQGQTWSAAAAYNNGPIGVAAGYFYTSNPSPTAGSRSTWSGSSDAIFDGAINSGYTSAKSIGIAQVAGQYVFGPVTVGLGYSNAQYKPDGFSGFSSTEKYNTGRGFVTYQATPALLLGLGYAYTKASGDTDAKYHQVSIGADYALSKRTDVYLAGAYQHASGTQRVDATTTQTAQASIGSYGVNGTKSQEMVALGLRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JS0</accession>
    <name>Q63JS0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544542.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111652.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1646"/>
    <dbReference type="EnsemblBacteria" id="CAH39120">
        <property type="protein sequence ID" value="CAH39120"/>
        <property type="gene ID" value="BPSS1646"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1646"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5933"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MNNACYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="137"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="389" mass="42988" checksum="F0EA9456A92BDB39" modified="2004-10-25" version="1">MAESSLVDDASADIPSLKKEIVRLNKIVRSLMDRAERSTIVCGSDFSLFQMAVTLEDQVRHRTRELEAALHENQKIMHALQRTQALMAQEIEERKRTQAELETEREAQRHLIEQLAQAHGQLLQSEKLASIGQLAAGVAHEINNPIGFVDSNLRTLKTWVRQLLDVMAIEDALIADCGDAALARLRAAHAEVDLDYLRGDIGTLIDESIEGASRVRRIVQDLRDFSRAGSEEWNFADVHEGLEATLNVLRNELKYKAEVVKDYGELPAVECMPSQLNQVVMNLLMNAAQAIVEHGTITIRTRREGDGVTIAIEDTGVGIPADRLAKIFDPFYTTKPVGKGTGLGLSVSYGIVEKHGGRITVDSEPGNGSRFTIWLPIVRQRSLQDAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW7</accession>
    <name>Q63JW7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative type IV pilus biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pilQ</name>
        <name evidence="4" type="ordered locus">BPSS1597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537540.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111605.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1597"/>
    <dbReference type="EnsemblBacteria" id="CAH39072">
        <property type="protein sequence ID" value="CAH39072"/>
        <property type="gene ID" value="BPSS1597"/>
    </dbReference>
    <dbReference type="GeneID" id="56529991"/>
    <dbReference type="KEGG" id="bps:BPSS1597"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4978"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TVHAGNI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="536" mass="58296" checksum="0081425337565503" modified="2004-10-25" version="1">MSHDAQRPDTAAARATPSAADAAAPPRGPRAVSEAGDFAASVEERKFVCLFDDGRLLIAEGHEMNPFVLSYRARLDRMGRPYRPTPATLMQVREAYRQHVAGGGERLDHTVMQVLAKELIGRACRERASDVHIRVRRFSTEVYFRIHNELMRVNEHTREHGERLLATLYGAMTTVSDNSYRPSERQDASIGDRDKLPDDLYGVRIATTPTSEGSLMVLRLLYNDAGDATDLAALGFAPEHVAAFRMLRAQPHGMNIISGPTGSGKSTTLQRMLAAQIDESHGSLHVITVEDPIEYPIDGAVQTPVANAPTEDARALAFAAAITNAMRLDPDTIMIGEIRDRASGQTALRASMTGHQVWTTVHANSALAIADRLIDLGLHARMITDHTVISGLISQRLVKLLCPHCKVRLLDHAERIEPGLLARLRLALDTRMSEVCITGDGCEQCGMAGTIGRTVVAEVILPDARLFEFLRDGDKVGALEYCTRTLGAMTLAEHALRKVAAGLVDPRGVERVVGALAPVTGDARQQLSLVGFSYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K45</accession>
    <name>Q63K45_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203128.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111527.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38994">
        <property type="protein sequence ID" value="CAH38994"/>
        <property type="gene ID" value="BPSS1521"/>
    </dbReference>
    <dbReference type="GeneID" id="56530071"/>
    <dbReference type="KEGG" id="bps:BPSS1521"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4875"/>
    <dbReference type="OMA" id="HRHRAIE"/>
    <dbReference type="PHI-base" id="PHI:3224"/>
    <dbReference type="PHI-base" id="PHI:4483"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="147" mass="16672" checksum="E583D5C1F7D6631F" modified="2004-10-25" version="1">MKLNGMTAAQAQHRHGAIERHAPGKDDGRRTAGVADEREGRTMKGEIKAIRMDVLKEIRFNSAVSTPVLLAKRNRIAANIREVSEKIDRKGLFGKMFEAVKCVAQRGLYYDRRALRKLDAFVVRHIGDRPEDRKFKVLPTRAQRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K97</accession>
    <name>Q63K97_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198543.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111475.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1469"/>
    <dbReference type="EnsemblBacteria" id="CAH38940">
        <property type="protein sequence ID" value="CAH38940"/>
        <property type="gene ID" value="BPSS1469"/>
    </dbReference>
    <dbReference type="GeneID" id="56597720"/>
    <dbReference type="KEGG" id="bps:BPSS1469"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4804"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DIPNLGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="33139" checksum="99A5373D852AF5EA" modified="2004-10-25" version="1">MRKGIPNLAALQVFEAAARHESFTRAADELALTQSAVSRQITSLEERLGVALFLRIKKRVVLTPHGRHYAALVRRNLERIERDTLELMAQRGIGATLELAVVPTFASQWLIPRLPQFRALRPDITVNLSVRTGPFLFSDSTFDAAIYFGHALWPGTQGRLLFLEGDMLPVCSPALLGANGRRITRDALLDLPLLHLSTRADAWRDWFRAQGLDNDLRAVRGPRYELFTMLTAAAHAGMGVALMPALLVADELASGRLCAPLDLRLPSDAGYYLVAPDAAADSEPFVALAEWLGSVSPARPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KC9</accession>
    <name>Q63KC9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184724.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111443.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1431"/>
    <dbReference type="EnsemblBacteria" id="CAH38906">
        <property type="protein sequence ID" value="CAH38906"/>
        <property type="gene ID" value="BPSS1431"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1431"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4759"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CCYALQD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="16874" checksum="25EAD87CE001B5A3" modified="2004-10-25" version="1">MKRFHVHVSVANLADSIRFYSALFAAEPTVVKEDYAKWMLEDPRVNFAISQRGAAPGLDHLGVQTEDDAALAEMRARLDHAALPVDAQIGAACCYARSDKYWSVDPQGIAWEAYRTLGEAPTFGVSRAARATGPNAGAPACCAPAHGQPAGAPTQSACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP4</accession>
    <name>Q63KP4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative alanyl-tRNA synthetase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524255.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111327.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1317"/>
    <dbReference type="EnsemblBacteria" id="CAH38788">
        <property type="protein sequence ID" value="CAH38788"/>
        <property type="gene ID" value="BPSS1317"/>
    </dbReference>
    <dbReference type="GeneID" id="56530263"/>
    <dbReference type="KEGG" id="bps:BPSS1317"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4612"/>
    <dbReference type="eggNOG" id="COG2872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYLCHEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="239" mass="25911" checksum="C7F2903F23201D12" modified="2004-10-25" version="1">MNRLFCQDDPDTLLLSGTVVDTRPGAVRLSRHPFYPGGGGQLPDLGTVRWEGGVETVAGFSEDGGGLWIEFANGVEIVGDVQSSVDAAFRRAMRELHTDLHVLNALVYRDFDGALVTGVQMNADRTARIDFDLPDADNDRLRALEAEMNDVVRRDLPVRTRYVPLADAQQASGLLRSRSVAPPPTADGLVRIVEIDGLDSQACGGTHLASTGGSSPVRILKIENKGRSNRRVRIGLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KV9</accession>
    <name>Q63KV9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524197.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111262.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1255"/>
    <dbReference type="EnsemblBacteria" id="CAH38722">
        <property type="protein sequence ID" value="CAH38722"/>
        <property type="gene ID" value="BPSS1255"/>
    </dbReference>
    <dbReference type="GeneID" id="56530328"/>
    <dbReference type="KEGG" id="bps:BPSS1255"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4517"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYPRNRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="36631" checksum="32B9AEFA5BE216B0" modified="2004-10-25" version="1">MDRFQEMQVFVRIAERQSFSRASDDLRIPRATVTNLMKRMEARLGARLLERTTRTVRLTQDGEAYYRRCVRLIADLEEAEGAFRAAAPRGLLRVNLQGTLARYFVVPALPDFLARYPGIRLHIGEDDRFVDLVREGVDCVLRSGNLQDSSMVGRRVAQLEQVTVASPGYLARHGEPAELAALAAHRAVDYVSSATGKPMPLEFTVDGRVTEVRLDAAISVAGVELYTGAAVAGLGIVQVPRYRIADELADGRLRIVLGAYPPPPMPVSVLYPHSRQLSSRVRAFAQWLRERFDAAQAGAGDGACGAPGSSGSAARAPSPARSEPAKALLSRRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L26</accession>
    <name>Q63L26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528418.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111195.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1182"/>
    <dbReference type="EnsemblBacteria" id="CAH38650">
        <property type="protein sequence ID" value="CAH38650"/>
        <property type="gene ID" value="BPSS1182"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1182"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4414"/>
    <dbReference type="eggNOG" id="COG3433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMIASTC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="79" mass="8830" checksum="36C74D1423CF403F" modified="2004-10-25" version="1">MTHTIDITETIHNTCRSVLGIPDLQSDEDFFERGVSSLTIVELQIQIEQLVQRQVPTSKLMAAPTVQGWSQVYREAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L29</accession>
    <name>Q63L29_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111192.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1179"/>
    <dbReference type="EnsemblBacteria" id="CAH38647">
        <property type="protein sequence ID" value="CAH38647"/>
        <property type="gene ID" value="BPSS1179"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1179"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5344"/>
    <dbReference type="eggNOG" id="ENOG5030X4Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CHAGHCE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032598">
        <property type="entry name" value="DUF4902"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16245">
        <property type="entry name" value="DUF4902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="147" mass="16142" checksum="59C3DB7CC876DA36" modified="2004-10-25" version="1">MRRAPRVGRRSHVAQRLAPASSAPAAAGRDGYVRLSLPQLARVSLAPICAAADDQILSELWDLGIGALRAGYCEWIDAHGAAPATLGWSWFVDVERIWRIVPDSLTSNLMIISAKGYDVGPANTRQCLLNWLTKFDWRGLLVPLIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LD0</accession>
    <name>Q63LD0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage baseplate assembly protein W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531058.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111091.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1079"/>
    <dbReference type="EnsemblBacteria" id="CAH38546">
        <property type="protein sequence ID" value="CAH38546"/>
        <property type="gene ID" value="BPSS1079"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1079"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4277"/>
    <dbReference type="eggNOG" id="COG3628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRWEPRL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="120" mass="12919" checksum="9C69960A0F255F61" modified="2004-10-25" version="1">MRGMNAETGRSMSGLDHLAQSIGRIVSTPLGSCIQRRTFGSELPDLIDAPANGATRIRLYAAIATALMRWEPRLTVTRVQISAAAADAFAGRQFVDIEGWTDEQDELVSLRVPMTNGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LP5</accession>
    <name>Q63LP5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198488.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110976.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0968"/>
    <dbReference type="EnsemblBacteria" id="CAH38430">
        <property type="protein sequence ID" value="CAH38430"/>
        <property type="gene ID" value="BPSS0968"/>
    </dbReference>
    <dbReference type="GeneID" id="56597334"/>
    <dbReference type="KEGG" id="bps:BPSS0968"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7285"/>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TDICGAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="32995" checksum="A15C87E4348D1F00" modified="2004-10-25" version="1">MIVRPREHGFRMLFVWNGSVLKSILPQLALMSAVSIVALLTNGRILGEKVPLNPTPFTLAGLALAIFAAFRNNASYDRYWEARKLWGGVLSAARALTSQALGYDALADGASFARATAGFVYALKHQLRGTDPTHDLRRRLPADWLDPVLAAQFRPVAILHALRGRLAGRHRDGALTDAQLWMLDAQLNELAAKLAGCERIASTPIPFPYHVLLHRTVYAYCVMLPFGLVDSIGIATPFVSVFVSYTLIALDAIAGEIAEPFGDGPNHLALDALTRQIERSLFELAGLPLPDEMRAGPNHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ML3</accession>
    <name>Q63ML3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530129.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110658.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0639"/>
    <dbReference type="EnsemblBacteria" id="CAH38096">
        <property type="protein sequence ID" value="CAH38096"/>
        <property type="gene ID" value="BPSS0639"/>
    </dbReference>
    <dbReference type="GeneID" id="56597675"/>
    <dbReference type="KEGG" id="bps:BPSS0639"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6831"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKQAFGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="17106" checksum="2D2B777A877524A3" modified="2004-10-25" version="1">MPTAVKPIPEGMHSLTPHLICDGAAAAIEFYKKAFDAVEISRLPSRDAGRLMHAAVRIGDSTLMLVDEMGQCGALSPKALKGSPVFIHLYVPDVDAVIARAVEAGAKLTMPPADMFWGDRYGQLEDPFGHRWSVATHRQDLTPEQIREGMASCVPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS4</accession>
    <name>Q63MS4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523157.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110595.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0574"/>
    <dbReference type="EnsemblBacteria" id="CAH38031">
        <property type="protein sequence ID" value="CAH38031"/>
        <property type="gene ID" value="BPSS0574"/>
    </dbReference>
    <dbReference type="GeneID" id="56530975"/>
    <dbReference type="KEGG" id="bps:BPSS0574"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6745"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIPYAFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="414" mass="44566" checksum="2B5C865406B66ADE" modified="2004-10-25" version="1">MDFDVIVLGAGIVGVSAALHLRDRGRRVALVDRGAPGDGTSFGNAGLIERSSVAPYAFARSPLALLRYAANRSTELYWDRAALPSFAPWLARFWWESSPRRHAAAARDMLPLIERSVAEHDALIARAGAGELVRACGWIEAYRTPARLEHATRDALLDASRHGLRVTALDAAALAAQEPALGPGFCGALHWLDPKSVVDPGALVKAYARLFARDGGTLLEGDAATLEAGDGGWRVRTAEGVAAARDVVVALGPWSDTVFAKLGYRLPLREKRGYHMHYAPPDGAPLSAPVVDLEHGYVVAPMRRGLRLTTGVEIAARTLPPTGVQLARAERVAQPTFRLGRRLDAAPWLGFRPCTPDMRPVIGAAPRHRGIWFAFGHNHHGLTLGPITGRLLAEMMCGGPTVANVAPFRAERFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MX6</accession>
    <name>Q63MX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS0522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525547.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110543.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0522"/>
    <dbReference type="EnsemblBacteria" id="CAH37979">
        <property type="protein sequence ID" value="CAH37979"/>
        <property type="gene ID" value="BPSS0522"/>
    </dbReference>
    <dbReference type="GeneID" id="56531029"/>
    <dbReference type="KEGG" id="bps:BPSS0522"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6682"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="STALIEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017729">
        <property type="entry name" value="ATPase_T6SS_ClpV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03345">
        <property type="entry name" value="VI_ClpV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="223"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="598"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="10">
        <location>
            <begin position="769"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="898"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="956" mass="102101" checksum="E26334DCDE92780D" modified="2004-10-25" version="1">MNRERIFNCLGRTTYAALVDATALGRSRRHAFIDLDHWALCLLQREQSDLARLFELFGSDAGEAKRRMEKALDGFDVSGDSLRDISSSLERSVGPAVIWSQIAARAGKVRSGHLLLAWLDEDLTRRWLQQRVPSGITSVALDDVVKRYEALAAGWPEADEAPAALDGAALGAQAGEAGADGTGDALAKWATCVTEQAARGELDPVVGRDDELRTVIDILSRRRQNNPILVGEAGVGKTAVVEALAQKIHAGAVPPGLVGAQVWALDLARMQAGAGVRGEFEQRLKSLIDAVIASPAPIILFCDETHTLIGAGGAAGTGDAANLIKPMLARGQLRMVAATTWSEYKQYIEPDAALVRRFQAVAVDEPSDDAAVDMLRTIAPRFAAHHGVRIVDSALRGAVELSRRYLPARQLPDKAISLLDTACARVAMSQSCAPAELERLQHQAFAIGQTLDWRASDRRMGVRTPGDEAELEGRQASLAQQAATLETVVDAQRDEVRAWLARLNDATPQAADGDGAAFAARIGANRWVRPWVDEHVVSEVLAEWTGVPVAQLAQDDAQRVVELEAALNAGIHGQTGAMRSIAQALQVSHSGLNDPRRPLGVMLLAGPTGTGKSQAAAKLAELLFGGERNLLQFNMNEFQEAHTVSTLKGAPPGYVGYGKGGRLTEAVRKKPYSVLLLDEFDRAHPDIHEVFYQVFDQGWMEDGEGRRISFRNCLILLTSNLGEAEIEAACKADPRISQAKLDKLVGERLQGRFSPALLARIQLVAFRTLDVDALTGIATQALDELGERLAQNDLQWRADEGVASWIAHAVSQHPANGRAVRDLLRQHVMPAVARGVLAARAEGRALKTVRLAANEKLSLVFDEDAWELSGTDAASLGEQAQAVAMAREAEAVAAAVAAREAHGAHGTNEADGGGGAPHAAKADAHVDSDDERPGGAPHPDETASANAGTTGEPSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NA9</accession>
    <name>Q63NA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552314.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110410.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0387"/>
    <dbReference type="EnsemblBacteria" id="CAH37838">
        <property type="protein sequence ID" value="CAH37838"/>
        <property type="gene ID" value="BPSS0387"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0387"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6515"/>
    <dbReference type="eggNOG" id="ENOG503296Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLRRFNV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021815">
        <property type="entry name" value="DUF3396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11876">
        <property type="entry name" value="DUF3396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="40741" checksum="A790266613261768" modified="2004-10-25" version="1">MTNEEIEAWAKDPRRADTLPFGLYEPPYRKGITGAALVVRGVLYFRNGFTPDVRQALVRCFKQYNAAIEEYQHALEVAAGQSPSKAGPLRWFYSEGEEPTQYDKAPGFESLARSVPANKTLAVAMTSAEHKLAAGFYEFTVFALSDWKAERKRGLDGLVFTVPRAFIVQRPGVFEAMFRAFAEALPTVSGHGGLAVNMPPMERRPNEASEYFYARRFGPGIDVGDPMRSNVRKLYTKIKTVDWLNALDAELVRAVGGTSSLALPPNWFARQPLRDGGLIIQAGVAPMSGVSNGTGIPVAPPAAYVLLNHALRQIVADTLDTLQDGTLDSTAPLLNTVVATAAWLRRFNVPDDQINGYWVELHKTPKLSPST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NE3</accession>
    <name>UVRB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein B</fullName>
            <shortName evidence="1">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrB</name>
        <name type="ordered locus">BPSS0356</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199587.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110376.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63NE3"/>
    <dbReference type="SMR" id="Q63NE3"/>
    <dbReference type="STRING" id="272560.BPSS0356"/>
    <dbReference type="PRIDE" id="Q63NE3"/>
    <dbReference type="EnsemblBacteria" id="CAH37804">
        <property type="protein sequence ID" value="CAH37804"/>
        <property type="gene ID" value="BPSS0356"/>
    </dbReference>
    <dbReference type="GeneID" id="56597206"/>
    <dbReference type="KEGG" id="bps:BPSS0356"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6479"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000227295" description="UvrABC system protein B">
        <location>
            <begin position="1"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="46"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="450"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="647"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <sequence length="696" mass="79428" checksum="F276C194D2005000" modified="2004-10-25" version="1">MSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGVTGSGKTYTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEVDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFPEFERKMRQVVFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVLITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDMSEKQIAKEIKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NG1</accession>
    <name>Q63NG1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative insertion element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0338"/>
    <dbReference type="EnsemblBacteria" id="CAH37786">
        <property type="protein sequence ID" value="CAH37786"/>
        <property type="gene ID" value="BPSS0338"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0338"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6457"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KQSIHHI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="407" mass="44255" checksum="92A666F8D46350E4" modified="2004-10-25" version="1">MQEATQHDAVDVFVGVDVDVGVDVGKGQHHAVALDRNGKRLYNKALPNDEVKLRALIAELKTHRRLLFVVDQPSTIGALPVAVARAEGVLVAYLPGLAMRRIADLHAGEAKTDARDAAIIAEAARSMPHTLRSLRLADEQLAELTMLRGFDDDLAAQLTQTSNRIRGLLTQIHPALERVLGPRLDHPAVLDLLERYPSPSALAAANEKTLANRLTKLAPRMGKNWAAEIVQALNEQAVIVPGTQAATIVMPRLAQQLAALRKQRDEIAAEVERLVLAHPFWPVLTSMPGVGVRTAARRLTEAAQKAFATAAHLAAYAGLAPVTRRSGSSIRGEHPSRRGNKVLKRALFLSAFAALRDPVSRAYSSRKIQQGKRHNQALIALARRRCDVLFAMLRDGTIYPPKSAPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NM2</accession>
    <name>Q63NM2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533780.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110297.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0277"/>
    <dbReference type="EnsemblBacteria" id="CAH37724">
        <property type="protein sequence ID" value="CAH37724"/>
        <property type="gene ID" value="BPSS0277"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0277"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6372"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EYMEGFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="338" mass="36809" checksum="62EB453742396786" modified="2004-10-25" version="1">MTLTSPHHDDVAVYDLTLGLFACPAMLIAHRAGLFRRLGESPSTLKELGAALGLARRPTEALANTAAALGFVRRDADRYALTALGADLLVERSPTYFGAFLDLMYEASETFSLKSLEAAIRDDAAHAYGSPDVFQSHEQQLALAQRFTRAMESVSAAHAPVWPTQLDLSRHRVMLDIGAGSGAHTRGALSAWPALRAIVFDLPGVCELSRPYFETSPVRERVTLHPADMRHDPFPDADLHFYSNVFHACPREKNALLARKSSDALPPGGRIVLHEVLYRDDKSGPLAAAASSLMMISWTEGEQYSSRELTEILANAGFSSLETIPSAGYYSLVTGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NX9</accession>
    <name>Q63NX9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531523.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110190.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0169"/>
    <dbReference type="EnsemblBacteria" id="CAH37614">
        <property type="protein sequence ID" value="CAH37614"/>
        <property type="gene ID" value="BPSS0169"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0169"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6231"/>
    <dbReference type="eggNOG" id="COG3522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SIKLELW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="448" mass="49275" checksum="7A27C7E72781F774" modified="2004-10-25" version="1">MSWHNKVVWSEGLFMRPQLFQQQERYLEHYAHKRAAPLSPFFFGFSHFSLDSEAPALGKIIVKSASGVFADGTPFDAPGSTPPPAPLTIRPEHLDQVIYLAVPIRVPNGEETAFDRAAESLARYAVFETDLRDTNSIGQGPKTVQLSNLRLRLLPEKELTDAWIGLALTRVKTIRADASIELDDMLIPPVVGYGASDTLASWLAKIHDLTRLRANALAERLTGSDGRAGTTAEVSDYLLLQTLNRYEPLLKHLQRVPTTSPAELYALLIGMAGELSTYVRTDTRRPLDTHPPYQHVAPHLCLKPVVDDTHRLLNAVLVRSAQRLALADLGHGMLNAVVDPVDMQGFTAVVLAVHAQMPPDLLQQQFAAQAKAGPSERLPDLVRSHLSGIALQALPVPPRQIPFNAGYVYYELARGGPLWDEVARHGGLALHIAGEFPSLKLELWGIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NY9</accession>
    <name>Q63NY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110180.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0159"/>
    <dbReference type="EnsemblBacteria" id="CAH37604">
        <property type="protein sequence ID" value="CAH37604"/>
        <property type="gene ID" value="BPSS0159"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0159"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6217"/>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGHTFPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267020" evidence="1">
        <location>
            <begin position="19"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="64"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="297"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="965" mass="99468" checksum="AA573C7C5B4A34E3" modified="2004-10-25" version="1">MNRFVRLGAAMAVACALAACGGDDGGPAVAASSFAAAGANGATAGVADTAQADGAPRTGSLTQYVDPLIGTLASNSPNPVPAGQAGSVVPAAGLPSGMIQWAPDTNTTPAPADSKEPGSPAGYYYDLNAIQGFSVTHMSGAGCAGNNGEFPVMPTTDATKLAPTFSHANETAKPGYYSVLLDSQIKVELTATLRTGFGRFAYPAGKPALLVIDATRTNTKTSTSGAITRVSANAISGSTVGGGFCGNSVPVPVYFYATFDRPFAPASSISRGIAKLAFDSGATVRMKIGISYVSVDNAKANLDAENRTWDFDGVRALADAAWNDRLGAIRVSSSDADALKKFYTAFYHALWAPSVFSDVNGQYIGFDKQVHTVAKGQAAQYSSFSGWDVYRSLIQLKAVLFPRETSDMIQSLVNDADQCGAIPHWVNDNVEDGVMPGDAGSLMVSSAYAFGAREFDARGALAHMIRMANIPGTACAGVTTNGGRASYLQTGYITSGEWGIASSTLEYTSSDFAISRFALALGDTATQKMLLGRSAYWQNLLNASLNPPLIAARQSNGAWIAETPGSTDNYVEGNAEQYTWMVPYDPAGLFTQLGGNQAVVPRLDKFFTVLNAGMSLPNFYMGNEPTFEVPWLYNWAGSPSGTQRVVRQIMQTAFSTKPDGLPGNDDLGAVSGWYVWAALGLYPQVPGVAGFAIGSPQFDAIDVRLGSGRMLKIRAPGAPASGYVQSVAVNGRAQASPWIALDALDGGAVMHFKMGGAPSQWGAGEAPPSFGVPVARDVADSFNNRGISADGATNADGQGADFDGSLFSYSANALAQAGVRPGAPFTYGGASFVLGGASSLDNAVAVGQTVMLPPGSAGTSVVVLGASNNGPSAGVARVSFADGTSAQVTLSFDDWTLNGGSTGATSAIAVTSAYRNAGNGQKDNVKTYIFAQKIPVPAGKVVTSVTLPRQVSAGKMHVFGIGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P46</accession>
    <name>Q63P46_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110123.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0100"/>
    <dbReference type="EnsemblBacteria" id="CAH37546">
        <property type="protein sequence ID" value="CAH37546"/>
        <property type="gene ID" value="BPSS0100"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0100"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4023"/>
    <dbReference type="eggNOG" id="COG3521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DAWYRAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017734">
        <property type="entry name" value="T6SS_SciN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038706">
        <property type="entry name" value="Type_VI_SciN-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37625">
        <property type="entry name" value="PTHR37625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12790">
        <property type="entry name" value="T6SS-SciN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03352">
        <property type="entry name" value="VI_chp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17601" checksum="562199F858E9FF0A" modified="2004-10-25" version="1">MAAMVCTSLAACASLPARKETADLIVKIKVSEGANPDEHQRPAPVMVRLYELKSAGAFENADFFTLQSDSRKVLGDDAIATDEFVMRPGDTRDIHRRADSAGTSVGVLVGYRELGKSVWRAVHKLRPAPEDAWYRAFTPRTKIKLNVDVGQQTVTITELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PC2</accession>
    <name>Q63PC2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome monooxygenase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194516.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110047.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0023"/>
    <dbReference type="EnsemblBacteria" id="CAH37466">
        <property type="protein sequence ID" value="CAH37466"/>
        <property type="gene ID" value="BPSS0023"/>
    </dbReference>
    <dbReference type="GeneID" id="56596768"/>
    <dbReference type="KEGG" id="bps:BPSS0023"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6022"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REHMAFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="468" mass="51591" checksum="87E06C586DE16199" modified="2004-10-25" version="1">MNGLPLSLPRVDSTDSLFADPLAFLARARAQCGDVFVLREHGPIFSRASDCSGVIAVFGEHRLRQVLTETDTFALPMSAAAKMALPKNLVNLNRGLHSMREPEHGRHKRLLTGTANRALFDAHRSGMQTDLSRFCEMLNGDGRISVVSRMRELTAKLASRLFLGPQCEEDAELTFLLSAYFTLRREASSPNAHDPLQYRDALIGAGRQLDRALRARIRRYRKAPAGECAGLLQRLATAGQPGSPALSEDEIVGHANVMFVSSTEPVAISLAWLLLVLSQLPDLRRALRAESAARASSPASPYDAPLLERVINETLRLLTPNALMVRATTQAVSLQGVALPARCEIVVCPFLVHREANAFARPHAFLPSRWETARPSPYEYFPFGAGGHFCAGRNLALSLIGEVLSTLLSRFDFVLDIEQFIDWRIHIMLMPKGDPTLTAHPVDERRDTPSPKWRGPVAELFHFAPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI4</accession>
    <name>Q63PI4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclohexadienyl dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pheC</name>
        <name evidence="6" type="ordered locus">BPSL3392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525749.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109985.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3392"/>
    <dbReference type="EnsemblBacteria" id="CAH37404">
        <property type="protein sequence ID" value="CAH37404"/>
        <property type="gene ID" value="BPSL3392"/>
    </dbReference>
    <dbReference type="GeneID" id="56527762"/>
    <dbReference type="KEGG" id="bps:BPSL3392"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1799"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQYGEKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01069">
        <property type="entry name" value="PBP2_PheC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037298">
        <property type="entry name" value="PheC_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266220" evidence="4">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="40"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="28889" checksum="37B315E6A6B5DC2C" modified="2004-10-25" version="1">MKMNQTLLALACCAGLAHAQTAPQPGAPASRLDDVLARGTLRVCTTGDYKPYTYRREDGAFEGIDIDMAASLAKSLGVKTAFVKTTWPTLTDDFVAKCDIAVGGISTTLERQKRVFFTQPYVSDGKTPIVRCADAERYQTIAQIDQPQTRVIVNPGGTNERFAKQHFTRAKLTVFPDNVTIFKQILAGNADVMVTDASETLLQQKLNPGLCSVHPDKPFQFGEKAYMVPRGDVVFQQYVDQWLHLARETGELRAISDKWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q89</accession>
    <name>Q63Q89_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199909.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109729.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3136"/>
    <dbReference type="EnsemblBacteria" id="CAH37146">
        <property type="protein sequence ID" value="CAH37146"/>
        <property type="gene ID" value="BPSL3136"/>
    </dbReference>
    <dbReference type="GeneID" id="56594092"/>
    <dbReference type="GeneID" id="66545697"/>
    <dbReference type="KEGG" id="bps:BPSL3136"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2107"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFVIMDP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="21954" checksum="576C5828D3832F9B" modified="2004-10-25" version="1">MDLLKSFISLLALINPLGAVPFFLSLTAQQTEAERRHTIRIAAVSVFCVIAVTTLLGQQIIDFFGISVGSLEVGGGIIMLLMAISMLNAQIGNTRSTPEERDEAESKNSIAVVPLAIPLLTGPGSISTVIVYAANARHWYDRLGLVAIGAALALICFFAMRLAEPIAHWIGRTGINIVTRLMGLMLSALAVEFIVDGLKALLPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QE7</accession>
    <name>Q63QE7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">BPSL3076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521981.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109671.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3076"/>
    <dbReference type="EnsemblBacteria" id="CAH37087">
        <property type="protein sequence ID" value="CAH37087"/>
        <property type="gene ID" value="BPSL3076"/>
    </dbReference>
    <dbReference type="GeneID" id="56528111"/>
    <dbReference type="KEGG" id="bps:BPSL3076"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2178"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="198" mass="21305" checksum="4A7DCD2CF1E04FC6" modified="2004-10-25" version="1">MEPRPAPPRRLIVAITGATGAIYGVRMLDMLRASGGVETHLLISSAGWLNIRHELQLSKDDVLARADVVHSVRDVGASIASGSFATEGMIVAPCSMKTLASIAHGLSDNLITRAADVALKERRRLVLLVREAPFNLAHLRNMTAVTEMGGVIFPPVPAFYAMPKTIDEIVDHTVARVLDMFALGAPLTAPWQGLREHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QF4</accession>
    <name>Q63QF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109664.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3069"/>
    <dbReference type="EnsemblBacteria" id="CAH37080">
        <property type="protein sequence ID" value="CAH37080"/>
        <property type="gene ID" value="BPSL3069"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3069"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3508"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SEFCVDT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="18658" checksum="DEACABBE85306783" modified="2004-10-25" version="1">MDMQRGLLQRAKPAHRLDEVVAGINRLTAAARAAGAPVCFVQHDGGADDDVVPGTPGWRLHAELTCADADWRIRKRASDAFHGTPLAAQLSAHGVDAVVICGYASEFCVDSAARRAALLGYRTTVVSDLHTTNDRAHLSAAQIVAHHNFIWSHCSFSGNGVAPRPLDEVIAAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QG5</accession>
    <name>Q63QG5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol:disulfide interchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dsbC</name>
        <name evidence="10" type="ordered locus">BPSL3058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thioredoxin family. DsbC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109653.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3058"/>
    <dbReference type="EnsemblBacteria" id="CAH37069">
        <property type="protein sequence ID" value="CAH37069"/>
        <property type="gene ID" value="BPSL3058"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3058"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3490"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMIVYKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03020">
        <property type="entry name" value="DsbA_DsbC_DsbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033954">
        <property type="entry name" value="DiS-bond_Isoase_DsbC/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018950">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009094">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10411">
        <property type="entry name" value="DsbC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54423">
        <property type="entry name" value="SSF54423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010005196" description="Thiol:disulfide interchange protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC_N" evidence="8">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="9">
        <location>
            <begin position="118"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="26022" checksum="F061DCBF9D6723B9" modified="2004-10-25" version="1">MICMKKTIRIAALALAAATATLGCTAQADQSTDKLKAALQSRLGADAPIKSVTKSPIAGLYEVNLGSQIVYSDASGDYVLLGELVNTKTHKNLTAERLAEINKIDFASLPLSNAIKVVKGNGARKIAVFSDPNCPYCKKLETTLQSVDNVTVYTFLYPVLSPDSTVKSKSIWCASDRVKSWQSWMLEHRAPTSAANCDTTALDKNLALGRGMNVTGTPTVFLADGTRLPGAVSADELNQALAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QN5</accession>
    <name>Q63QN5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194406.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109583.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2989"/>
    <dbReference type="EnsemblBacteria" id="CAH36999">
        <property type="protein sequence ID" value="CAH36999"/>
        <property type="gene ID" value="BPSL2989"/>
    </dbReference>
    <dbReference type="GeneID" id="56594238"/>
    <dbReference type="GeneID" id="66548387"/>
    <dbReference type="KEGG" id="bps:BPSL2989"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2284"/>
    <dbReference type="eggNOG" id="COG3133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GCAYNSS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267451" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Rick_17kDa_Anti" evidence="2">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="157" mass="15362" checksum="5F1ECEBE29BA7E7F" modified="2004-10-25" version="1">MLTRKTLTLAAMLTATVTLAGCFTPPGSADVYSVGQAQREQTVRMGTVESVRAVRIQGDGGGSALGTLGGGALGAVAGSAIGGGRGSVLTAIAGGIAGAVAGNAVGQGLSSANGVEITVRLDNGDLRSITQAATPEVFRAGERVRLLSSGGVTRVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QR6</accession>
    <name>Q63QR6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527757.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109552.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2958"/>
    <dbReference type="EnsemblBacteria" id="CAH36968">
        <property type="protein sequence ID" value="CAH36968"/>
        <property type="gene ID" value="BPSL2958"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2958"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2319"/>
    <dbReference type="eggNOG" id="COG4290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AANDCYY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="143" mass="15527" checksum="EDD2491F39EC0BF4" modified="2004-10-25" version="1">MARKWLRNGALASVFAIVAMGNIGATPGSLVSAAYAREAATVDGAAAQVDTIPASRLPREAATTLSLIAAGGPYPYGKDGAVFGNYERILPKMRRGYYHEYTVPTPRTRNRGARRIVCGGPLRRVDNCYYTGDHYNSFKRIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QS3</accession>
    <name>Q63QS3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522068.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109545.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2951"/>
    <dbReference type="EnsemblBacteria" id="CAH36961">
        <property type="protein sequence ID" value="CAH36961"/>
        <property type="gene ID" value="BPSL2951"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2951"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2328"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMHISNQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="399" mass="40680" checksum="6C52C49D2054D626" modified="2004-10-25" version="1">MNSVTAPSPALTRGMTLLFACACGIVIGNLYYSQPLLAAIAASFGRQPAELGYLVTLTQLGYAASLLVVVPLGDVVNRHTLIVRLLVANVVALVAVASSTRYGFFVAANMCVGFVTCSTQLLVPFAASLADDGARGRAIGTVMSGLLLGILLARVASGAIADWLGWRAVYAIAAAMVLLLAGVLAAKLPKDRRHARVDYAALMQSLAALVRAQPLIALRSAYGALVFACFSLLWTGLTFLLSQPPYGYTEGRIGLFGIVGAVGALAAASAGRLVDRGHGNAATGLFAAAVLASFAAIAAGEQSLAALIVGILVLDIGVQGLHISNQSVIYALAGDARSRVTTIYLTSYFIGGALGSGAAGAAFGIDGWRGVCIAGAILSGSLVALWGASQRVGARQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QU7</accession>
    <name>Q63QU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109521.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2927"/>
    <dbReference type="EnsemblBacteria" id="CAH36937">
        <property type="protein sequence ID" value="CAH36937"/>
        <property type="gene ID" value="BPSL2927"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2927"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3344"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DAWWFMF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="31"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="485" mass="49904" checksum="53BD49572B0BAA65" modified="2004-10-25" version="1">MPFFHHPPSTGIREASPMDTLRTSLRSGNWRSLLACFLYFDTGFTVWVLYGPLAPFISKDIAMTAAQQGFLVAVPVLAAAILRVTLGNLYQSADGRRIALMGVLLSALPAAVLPFVPGTPSYTLLLVLGVFLGIGGASFAVALPMAGSSYPPKVQGLVLGLAAAGNIGAVLDGFMFPHIAAALGWKFSTTAALPLLAIAGFALFAWADDRAEKSGSAARAFGAFVITLGGLVALVLAVHAGLFGAGKAGVLLLPVMGALLAIAVLPGRYRAVLAERDTWVIMLIYSITFGGFVGMSSYVTLLLTTLYQMPKIEAGLFMSLLAFLGAIVRPFGGHLADRITGVRALMAILAAIAAADFAFAAVMPPLAGGIALLVCLYVAFGLGNGSTFQLVPHRWQGKTGLLSGIVGAAGGIGGFYLPVVMGIAKESTGSYQLGFATFGALATCALVALAMLRAQWLRWAAPELAAAEPSAGAGMPIGGAARVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV9</accession>
    <name>Q63QV9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family C44 non-peptidase homologue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194094.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109509.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2915"/>
    <dbReference type="EnsemblBacteria" id="CAH36925">
        <property type="protein sequence ID" value="CAH36925"/>
        <property type="gene ID" value="BPSL2915"/>
    </dbReference>
    <dbReference type="GeneID" id="56593752"/>
    <dbReference type="KEGG" id="bps:BPSL2915"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2372"/>
    <dbReference type="eggNOG" id="COG0121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWVFAHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="33748" checksum="315E17E6F0AF5EA1" modified="2004-10-25" version="1">MCQLFGMNCAEPTDVTFSFTGFAARGGLTDHHADGWGIAFFEDKACRLFIDQQSSSTSPIAEMVKRYPIKSKNTIAHIRKATQGHILLENCHPFMRELWGRHWIFAHNGDLQSYVPDLEGGVYQPVGTTDSEKAFCKLMQGLREAFPSAQPPLPELFEQIGELTRDITRHGVFNFLMSNGQALFAHCSTRLHYLVRRWPFSTAHLIDEDISIDFAKYTTPEDRVAVIATQPLTDDEVWTALEPGELVMFQCGDVAATMRIPVPEAVLEKLRNPAFDASASAPRRSPALAASGAGDDLGDDPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R51</accession>
    <name>Q63R51_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL2822</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527677.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109417.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2822"/>
    <dbReference type="EnsemblBacteria" id="CAH36832">
        <property type="protein sequence ID" value="CAH36832"/>
        <property type="gene ID" value="BPSL2822"/>
    </dbReference>
    <dbReference type="GeneID" id="56528376"/>
    <dbReference type="KEGG" id="bps:BPSL2822"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2482"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRIDTHF"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="13">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH36832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="19187" checksum="5CA50D7C7EBCC7C9" modified="2004-10-25" version="1">MTVAYLGLGANLGDARQALKDAVVCLAQQHAITVLGKSSLYRTAPVDASGGDYYNCVVKIDTVLAARTLLALCQKIEHHFGRERPYRNAPRTLDIDILLYGELTIDEPDLVVPHPRLTERAFALVPLVEIEPALAIPARGRADGFLADVAHQRIEKVQTCQCLAMRAAAEKNRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R93</accession>
    <name>Q63R93_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative capsular polysaccharide transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109375.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63R93"/>
    <dbReference type="STRING" id="272560.BPSL2780"/>
    <dbReference type="EnsemblBacteria" id="CAH36789">
        <property type="protein sequence ID" value="CAH36789"/>
        <property type="gene ID" value="BPSL2780"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2780"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2533"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LQFPYAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="42343" checksum="EC7CFA80A778B54F" modified="2004-10-25" version="1">MGSLGEAGGIAPPKRTCGARVRRLMKRVTLCAALAALSACGVAPGMRMKQPANVPVSSAAADAPAEAGRKPRGEQLPVPITDIDLSLIRTLRDAQQAPRRAADLVSPASGYTIGRGDVLQITVWDHPELAAALGTQQQTAARAADAPAGFVVDQDGTLQYPYVGRIAVAGLKPEQVQARLARQLAQTFRDPQVTVRIASFRAKQVYIEGEVHTPGSQALNDIPMTLYDAVSRAGGFSASADQRRVTLVRDGVERRIDLSGAAQGVNPSRIVLRDGDLLRIPPRDESGVFVMGEVNRPVTALPMRNGRLTLSEALSQAGSLNATTADAAQLYVIRGSLDAKPHVYRLDASSPVAMVLANQFELEPKDIVYVDGNGLVRFSRVLSLLLPAVNAGLTAAVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC1</accession>
    <name>Q63RC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109347.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2751"/>
    <dbReference type="EnsemblBacteria" id="CAH36759">
        <property type="protein sequence ID" value="CAH36759"/>
        <property type="gene ID" value="BPSL2751"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2751"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3142"/>
    <dbReference type="eggNOG" id="ENOG5033B54">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPALKWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021751">
        <property type="entry name" value="DUF3318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11780">
        <property type="entry name" value="DUF3318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="16819" checksum="071F4C317C6216A2" modified="2004-10-25" version="1">MSYSAPEQRFHTASQRRHMSAAQYRALRKELLILRSDVERLELAQAGAELRQSITHFKWLKLLVPGVSGGSLGKSARNVNATLGMLVSQYPLLSSLASVVLAKPVRALLRASARPALKWGAVGFALWEGYQIWKQAKHDDASDAGARQRTRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RY4</accession>
    <name>DSBB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Disulfide bond formation protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Disulfide oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dsbB</name>
        <name type="ordered locus">BPSL2537</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsbB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189653.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109133.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="5VYO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.49 A"/>
        <property type="chains" value="E/F/G/H=99-104"/>
    </dbReference>
    <dbReference type="PDBsum" id="5VYO"/>
    <dbReference type="AlphaFoldDB" id="Q63RY4"/>
    <dbReference type="SMR" id="Q63RY4"/>
    <dbReference type="STRING" id="272560.BPSL2537"/>
    <dbReference type="EnsemblBacteria" id="CAH36544">
        <property type="protein sequence ID" value="CAH36544"/>
        <property type="gene ID" value="BPSL2537"/>
    </dbReference>
    <dbReference type="GeneID" id="56596419"/>
    <dbReference type="KEGG" id="bps:BPSL2537"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2839"/>
    <dbReference type="eggNOG" id="COG1495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGALYMQ"/>
    <dbReference type="BRENDA" id="1.8.5.9">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00286">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003752">
        <property type="entry name" value="DiS_bond_form_DsbB/BdbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022920">
        <property type="entry name" value="Disulphide_bond_form_DsbB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023380">
        <property type="entry name" value="DsbB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02600">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158442">
        <property type="entry name" value="SSF158442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000298346" description="Disulfide bond formation protein B">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="65"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="164"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00286"/>
        </source>
    </evidence>
    <sequence length="169" mass="18114" checksum="60C4F39CBD84855C" modified="2004-10-25" version="1">MNNLTLSLRRERRLLVLLALVCLALLAGALYLQYVKNEDPCPLCIIQRYFFVLIAVFAFIGAGMASGAGVAVTEALIVLSAAAGVGTAARHLYVQLNPGFSCGFDALQPVVDSLPPARWLPGVFKVAGLCETVYPPIFGILLPGWALIAFVLIAVPVAVSLLRHRGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S00</accession>
    <name>Q63S00_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gyrA</name>
        <name evidence="10" type="ordered locus">BPSL2521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527513.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109117.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63S00"/>
    <dbReference type="STRING" id="272560.BPSL2521"/>
    <dbReference type="EnsemblBacteria" id="CAH36528">
        <property type="protein sequence ID" value="CAH36528"/>
        <property type="gene ID" value="BPSL2521"/>
    </dbReference>
    <dbReference type="GeneID" id="56528662"/>
    <dbReference type="KEGG" id="bps:BPSL2521"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2860"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="9">
        <location>
            <begin position="11"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="569"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="866" mass="96159" checksum="CCCCAF2839748156" modified="2004-10-25" version="1">MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPSRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKSWDSSLVRDMLTRAETENAAAGGRDAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYRDVMAQIADLLDILARPERITTLIGDELTQVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKYVFMTTALGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDVRPMGREARGVRGMQLDDAQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGRVVAATLVDPEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEADADADDDAVEGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S10</accession>
    <name>Q63S10_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">udg</name>
        <name evidence="12" type="ordered locus">BPSL2511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527508.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109107.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2511"/>
    <dbReference type="EnsemblBacteria" id="CAH36518">
        <property type="protein sequence ID" value="CAH36518"/>
        <property type="gene ID" value="BPSL2511"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2511"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2870"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="328"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="218"/>
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        <ligand>
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            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
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            <position position="277"/>
        </location>
        <ligand>
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            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH36518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="466" mass="50606" checksum="373206BFA4CE71E1" modified="2004-10-25" version="1">MKITIIGTGYVGLVTGACLAEIGHDVFCLDVDPRKIDILNNGGMPIHEPGLQEIIARTRAAGRIAFSTDIEASVAHGEIQFIAVGTPPDEDGSADLQYVLEAARNIGRHMTGYKVIVDKSTVPVGTAQRVRAVIDEALAARGLAGSAEHRFSVVSNPEFLKEGAAVDDFMRPDRIIIGVDDDAAGAIAREKMKKLYAPFNRNHERTIYMDVRSAEFSKYAANAMLATRISFMNEMSNLADRVGADIEAVRRGIGSDPRIGYHFLYAGVGYGGSCFPKDVQALIRTASENGQPLRILEAVEDVNHAQKNVLLDKIEKCYGADLAGRTFAVWGLAFKPNTDDMREAPSRRLIASLLARGATVRAYDPVALDEARRVFALDLHDGADALARLAFVDSADDALAGADALVIVTEWKEFKSPDFAHLKSVLKAPVIFDGRNLYEPDAMAELGIDYHAIGRPYVEPFSSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S23</accession>
    <name>Q63S23_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein alpha-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">etfA</name>
        <name evidence="7" type="ordered locus">BPSL2499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2499"/>
    <dbReference type="EnsemblBacteria" id="CAH36505">
        <property type="protein sequence ID" value="CAH36505"/>
        <property type="gene ID" value="BPSL2499"/>
    </dbReference>
    <dbReference type="GeneID" id="56596460"/>
    <dbReference type="KEGG" id="bps:BPSL2499"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2883"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
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        <property type="entry name" value="ETF_a/FixB"/>
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    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
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        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="31642" checksum="B322AFDC68EF20C6" modified="2004-10-25" version="1">MTILVIAEHDNASIKAATLNTVAAATKIGGDIHVLVAGHNAQGAADAAAKIAGVSKVLLADAPQLADGLAENVEATALNVAKDYSHILAPATAYGKNIAPRIAAKLDVAQISDITAVDSADTFERPIYAGNAIATVQSSDPIKVITVRATGFDPVAAQGGSASVEKIDAAADAGVSQFVSREVTKLDRPELTSASIIVSGGRGLGSGENYTKVLEPLADKLQAALGASRAAVDAGYVPNDYQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDPEAPIFSVADYGLVGDLFTLVPELVNELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SI6</accession>
    <name>Q63SI6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550170.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108930.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2334"/>
    <dbReference type="EnsemblBacteria" id="CAH36337">
        <property type="protein sequence ID" value="CAH36337"/>
        <property type="gene ID" value="BPSL2334"/>
    </dbReference>
    <dbReference type="GeneID" id="56528853"/>
    <dbReference type="KEGG" id="bps:BPSL2334"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3089"/>
    <dbReference type="eggNOG" id="ENOG50332P1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MKQTHAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="16738" checksum="33489E40C688B409" modified="2004-10-25" version="1">MKTLDVSQAAAAAHAGGVLSAVLKAEGGSFYVELETRTAGTAVLVTSNNRRPRAFRNPVKALEVIRELGLQSGRFSLEAWRPDEVEIERSSRPDRAAAMKQTHANAAAYDKWLREQVQASIDDPRPSIEHEDVMKKALARVEAMRKGKRAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SL9</accession>
    <name>Q63SL9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="4 10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pdhA</name>
        <name evidence="14" type="ordered locus">BPSL2301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199569.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108897.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2301"/>
    <dbReference type="EnsemblBacteria" id="CAH36304">
        <property type="protein sequence ID" value="CAH36304"/>
        <property type="gene ID" value="BPSL2301"/>
    </dbReference>
    <dbReference type="GeneID" id="56596096"/>
    <dbReference type="KEGG" id="bps:BPSL2301"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3127"/>
    <dbReference type="eggNOG" id="COG2609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PDEYRTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="12">
        <location>
            <begin position="121"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="13">
        <location>
            <begin position="492"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH36304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="898" mass="100329" checksum="4E726803739D7E0A" modified="2004-10-25" version="1">MSAVPNEVMKYVAAERDDDAQETVEWLEALDGVISSVGPGRAHYLIEKQIEFARMHGEHLPFSANTPYINTIPVEAQAKIPGDQDIEHRIRSYTRWNAIAMVLRAGKHTNVGGHIASFASAATLYDVGYNHFWHAPSAEHGGDLVFVQGHSSPGIYSRAFLLGRLTEDQLDNFRQEVGGNGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLQARGIVKTEGRKVWAFLGDGETDEPESLGAIGMASREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDALFARDKTGALMRRMMEAVDGEYQTYKSESGAYVREHFFNTPELKALVADWSDDDIWNLNRGGHDPHKIYAAFHEASNSKGAPTVILAKTIKGYGMGEAGQAMNITHQQKKLPVEQLKKFRDQFRLPIADDVIADVPYLKFDEGSKELEYMRAHRQALGGYLPQRRQKAQSLPVPALDAFEPLLKGTGEGREISTTMAFVRILNILLKDKALGKRVVPIVPDESRTFGMEGLFRQIGIWNQEGQKYVPEDSDQLMFYKESETGQILQEGINEAGGMCDWIAAATSYSTHGEIMVPFYIFYSMFGFQRIGDLAWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSLMWAASVPNCVSYDPTFGYELAVIVQDGLRRMVQEQEDVYYYVTVMNENYEHPAIPQGEHVAADIIKGMYAFRKADADKKAPRVQLLGAGTIFNEVIAAADLLKNDWGVAADLWSVPSFTELAREGHDVERWNLLHPAEARRLSHVQTCLKDTQGPVIASTDYVRALADQIRGQIDRRYVVLGTDGFGRSDTRGALRHFFEVDRYWVTVAALNALADEGTIERKVVADAIAKYNLDPAKPNPMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ST6</accession>
    <name>Q63ST6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AcrB/AcrD/AcrF family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550238.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108830.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2235"/>
    <dbReference type="EnsemblBacteria" id="CAH36237">
        <property type="protein sequence ID" value="CAH36237"/>
        <property type="gene ID" value="BPSL2235"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2235"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3205"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQDFSIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="914"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1048" mass="112383" checksum="F5F22C81DEA34E13" modified="2004-10-25" version="1">MSRNLFAVFIRYPVATCLMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSKIPYVTQMTSQSTLSSTSIVLQFSLERSIDAAANDVQSAIDAAAAQLPADLPSPPTFQKVNPADSPIMLLSAISSTLPLTTIDDYVETRLTKSLSQIDGVGSVSIGGQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVFNGTTRSYTIYTNGQLTEPAQWNDAIVAYRDGTPVRIRDIGQAVLGPEDNTLAAWIDGRRAISVGIYKKPGANTVSTVDKILARLPELEASLPPSLKIAVLADRTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGYSLDNISLMAMTIAVGFVVDDAIVMVENIARHVEAGERPLQAALKGLSETSFTIASISLSLVAVLLPLLLMSGIIGRMFREFAVTLSMTIIVSAFVSLTLTPMMASYLLRAHRHDAGRPPRPGLFERAFARTAAAYERALDVALRHRFVTLCAFFASVAASVFLYVGIPKGFFPQQDTGVITGISEAAQTISVEDMARHSMALAAIIRADPAVEHCQMAVGGSAYAGTTVNNGRWYITLKPRDQRDATADEVIRRLRPQFAKVPGVRMYLQAAQDVIIGARLARTQYQLTLQSADVGALTTWAPRLLARLSGLPQLRDVASDQQVNGSALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQVAQYFTQLSTYKVIMETLPSLQRDPGTLDRIYMKAPSGALVPLSSVARWTTDTVQPLSVNHQSHFPSVTISFNLAPGVSLGEATAAIEAARASLRMPPAVVGSFQGTAQAFQSTLATMPMLILSALIVAYLVLGALYGSFIHPWTILSTLPSAGVGAIATLWLFKYDFNLIALIGVILLIGIVKKNGIMMVDFAIAATRERNMTSLDAIRSACLLRLRPIMMTTMTALFGALPLMLTPGMGSELRQPLGYAMVGGLLVSQVLTLFTTPVIYLYLDTLSNRLKARLRPLGADMPSNAHVEGATQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SX5</accession>
    <name>Q63SX5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521166.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108791.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2196"/>
    <dbReference type="EnsemblBacteria" id="CAH36198">
        <property type="protein sequence ID" value="CAH36198"/>
        <property type="gene ID" value="BPSL2196"/>
    </dbReference>
    <dbReference type="GeneID" id="56528999"/>
    <dbReference type="KEGG" id="bps:BPSL2196"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3251"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFIRELH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="17546" checksum="5F25AD4FE543BCEE" modified="2004-10-25" version="1">MSDSAAAPLVYLLRPAASGDFEFAEALTHGNMNAYYQRHGLRWRADLFFASWRDSENFILELDSVSIGLLRITEEGDSLHIRDVQIAPGHRQRGAGTYLLETSHRFAKARGLRETQLRVFVDNPAARLYLRMGYRLAGPRLAQFGSIRHMARPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T44</accession>
    <name>Q63T44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192577.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108722.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2125"/>
    <dbReference type="EnsemblBacteria" id="CAH36128">
        <property type="protein sequence ID" value="CAH36128"/>
        <property type="gene ID" value="BPSL2125"/>
    </dbReference>
    <dbReference type="GeneID" id="56595910"/>
    <dbReference type="KEGG" id="bps:BPSL2125"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3339"/>
    <dbReference type="eggNOG" id="COG3812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMFPLVR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="PTHR36922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="168" mass="18337" checksum="553244E10E289C2E" modified="2004-10-25" version="1">MALSMYDVSIPALIRGLNNLSAVLDKGDAHARAQGIDPAELVRARLRDDMYALDAQVQRASDTAKGCGARLAGIEVPSFADTETTFAELRARIGKTIDFLKTIQPAQLDGSESRTIELPLRDGVMTFDGKSYLVGFALPNFYFHTTTAYDILRHKGVPLGKMDYLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T54</accession>
    <name>Q63T54_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="5">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ureidoglycolatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">allA</name>
        <name evidence="6" type="ordered locus">BPSL2115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism; (S)-allantoin degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ureidoglycolate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193471.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108712.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63T54"/>
    <dbReference type="STRING" id="272560.BPSL2115"/>
    <dbReference type="EnsemblBacteria" id="CAH36118">
        <property type="protein sequence ID" value="CAH36118"/>
        <property type="gene ID" value="BPSL2115"/>
    </dbReference>
    <dbReference type="GeneID" id="56595899"/>
    <dbReference type="KEGG" id="bps:BPSL2115"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3352"/>
    <dbReference type="eggNOG" id="COG3194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLNDKPY"/>
    <dbReference type="UniPathway" id="UPA00395"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00616">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023525">
        <property type="entry name" value="Ureidogly_lyase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="PTHR21221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017306">
        <property type="entry name" value="Ureidogly_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="170" mass="18497" checksum="6BFD9B4F1C620573" modified="2004-10-25" version="1">MKTLSIEPLTRAAFAPFGDVIETQGAKQIPINLGTTMRFHDLAKIDVADEGGRPLVNLFRGQPRTLPFEVTMLERHPLGSQAFVPLTDRPYIVVVAPAGDLDASKIRAFVTSGWQGVNYAKGVWHHPLIALGEVSDFIVVDRGGDGRNLNEQNLPESLWLTDDALLAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T87</accession>
    <name>Q63T87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531134.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108679.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2080"/>
    <dbReference type="EnsemblBacteria" id="CAH36081">
        <property type="protein sequence ID" value="CAH36081"/>
        <property type="gene ID" value="BPSL2080"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2080"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.79"/>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTVVEKI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="16"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="930" mass="100868" checksum="F9C8E5E3570DD977" modified="2004-10-25" version="1">MKPRATLRLQLHAGFTFDDAAAHVGYFARLGVSHLYLSPITAAEPGSRHGYDVVDYSTVNPELGGEAAFVRLIDALRRRSMGAIVDIVPNHMGVGGSSNRWWNDVLEWGTRSRFARHFDIDWHASDPALQRKVLLPCLGRPYGEALAAGDIALRADAAHGRFAIACAGRTLPVQIGAYPDILRAANRSDLNALAERFDAPGARPSNHARLDAAHAALRDYAAARGPGALDAVLHGFDPRIARSREMLHRLLEQQHYRLAWWRTATDEINWRRFFDISTLACMRIEDAAVFDDVHALLWRLYAAGLVDGVRIDHVDGLADPRGYCRQLRGRLAALRDGEPYIVVEKILAPDERLPEDWRVDGTTGYDFMNDVSALLHDAAGAAPLAALWADMTGAETTFAREALDGKRRVLARQFAAEHERVARAMHRLARASRDARDFALNPIRRAVAELAIRLPVYRLYPSAGAPQRTDRALLAGAWQAARSAIAPADRAALDYVAATLGLPGVARAVAGLGDPARLAARVGFAQLTAPLAAKGVEDTACYRYGRLLSRNEVGAHADALSLAPGAFHTRNRRRRRTFPGALLATATHDHKRGEDARARLAVLSEAHRAWRAAALDWAAFNAPHRHGAPAAADRIPGPAAEAMLYQTLVGAWPPALAPDDAPGLAALTDRVERWQLKALREAKRDTDWLEPNLGYEAGCAAFLRAIMTPRGPDDFAHRLHRLVARIAPAGIVNSLSQAALRLLSPGVPDLYQGAQTWDHTLVDPDNRADVPFARYAAQRIDAPVAAYLRDWADGRVKHALIGRLLALRAAHPETFAAGAYVPLHVRGTRRGHALAFARRDASTTIVVIATRLAYPLLGDAPARPCVEAACWADTAVGLAPGFAGPWRDVLNDGTLDAPSGMLPLAAALAHLPVAVLIREGGAADTPRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TI0</accession>
    <name>Q63TI0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536378.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108586.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1988"/>
    <dbReference type="EnsemblBacteria" id="CAH35987">
        <property type="protein sequence ID" value="CAH35987"/>
        <property type="gene ID" value="BPSL1988"/>
    </dbReference>
    <dbReference type="GeneID" id="56526354"/>
    <dbReference type="KEGG" id="bps:BPSL1988"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2240"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWTIFLE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="146"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="345" mass="36911" checksum="B6696589BF39C239" modified="2004-10-25" version="1">MTVSHSAAAVRIGIAGLGRLGRRHAENLARRVAGARLAAACSPLADECAWARETLAVPRVYEDFDALAADPELDALWLVTPSALHADQIVAALRAGKHVFCEKPLSLDLGECERVLAEARARPHLVATIGFMRRFDPSYRDAYARVAAGEIGRPFLVRSQTCDRNDPEGFFVRFAPSSGGIFLDCTVHDIDVARWLLGAPRATRVYAAGAVALHEGLRACGDVDNGVAICEFEGGRLAMFYASRTMAHGNDTHSEVIGTAGALAIGRNPRANRVEIYDAAGIRNTCTPTFFDRFEDAFLIEAQAFVAAVRGEGAAGGATLADALEATRIGHALRESLQTGRAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TJ4</accession>
    <name>Q63TJ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191885.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108572.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1974"/>
    <dbReference type="EnsemblBacteria" id="CAH35973">
        <property type="protein sequence ID" value="CAH35973"/>
        <property type="gene ID" value="BPSL1974"/>
    </dbReference>
    <dbReference type="GeneID" id="60549785"/>
    <dbReference type="KEGG" id="bps:BPSL1974"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4125"/>
    <dbReference type="eggNOG" id="ENOG5033A7D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYRFFWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012451">
        <property type="entry name" value="DUF1656"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07869">
        <property type="entry name" value="DUF1656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="7533" checksum="9FF6C933B76201A4" modified="2004-10-25" version="1">MMPRDLAILDAYVPTVVLMFVIGAFATWLIDRLLAYTGLYRVVWHPSLFRASLLVCICGGLSLAVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TR0</accession>
    <name>Q63TR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550551.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108506.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1906"/>
    <dbReference type="EnsemblBacteria" id="CAH35906">
        <property type="protein sequence ID" value="CAH35906"/>
        <property type="gene ID" value="BPSL1906"/>
    </dbReference>
    <dbReference type="GeneID" id="56595448"/>
    <dbReference type="KEGG" id="bps:BPSL1906"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4050"/>
    <dbReference type="eggNOG" id="COG1485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDEMQIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="365" mass="42350" checksum="7021D6CB7242F3A9" modified="2004-10-25" version="1">MNVTEYYEHELKTRGYQSDAAQRAAVERLQRCYGEWVAYKARRSNAFKKLVVRPDLPRGVYMWGGVGRGKSFLMDSFYAVVPVQRKTRLHFHEFMREVHRELEELKGQADPLDELARRIAKRYRLICFDEFHVSDIADAMILYRLLDRLFSNGVQFVMTSNYDPDDLYPDGLHRDRMLPAIALLKERLDVLNVDAGVDYRQRTLTQVRMYHTPLGADADRELRHAFAQLAAVPDESPILHIEKREIKALRRADGVVWFDFATLCGGPRSQNDYLELASRFHAIVLSDVPQMSPRMASEARRFTWLIDVLYDHKVKLLMSAAVPADDLYVEGPMANEFSRTVSRIVEMQSKEYIEAPRRLIDTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TV0</accession>
    <name>Q63TV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system, cystine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191674.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108466.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1867"/>
    <dbReference type="EnsemblBacteria" id="CAH35866">
        <property type="protein sequence ID" value="CAH35866"/>
        <property type="gene ID" value="BPSL1867"/>
    </dbReference>
    <dbReference type="GeneID" id="56595659"/>
    <dbReference type="KEGG" id="bps:BPSL1867"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4001"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WFGIDVS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267139" evidence="4">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="38"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="38"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="28253" checksum="CF1907F7CD495360" modified="2004-10-25" version="1">MKIASLKKLLVTGLIGASFAAATAHAADLLDEVKQRGTLRIGLEGTFPPFNSKNPQGELVGFDVDIAKAIAAKLGVKPEFVTTEWSGIIAGLQAGKFDVIVNQVGITDPRKQTLDFSPAYTFSSAQLIQRKDDARQFKSLEDLKGKKLGVALGTNYMDMAKSVPGIDVKTYPGAPEYLRDLAAGRLDAALNDRLMLAYLTKNAQLPLRPGANVGSANPSGIPFKKGNPKFAKAIADAMTQLEADGTFTKISDKWFGIDVTKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U80</accession>
    <name>Q63U80_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937387.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108336.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35735">
        <property type="protein sequence ID" value="CAH35735"/>
        <property type="gene ID" value="BPSL1736"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1736"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3833"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VWCPEGL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="28288" checksum="9DA322FC071C2E61" modified="2004-10-25" version="1">MSSDPHTAPQSAPQNIYDDASFFEGYRTLRQGDTGLNGALESPAMKGLLPNLAGLHVLDLGCGFGDFARYARAHGAASVTAVDVSSRMLEEARARTDDGAVTYLQRSIETYHAATRAFDLVVSSLTLHYVEDYAGVVARIYDALRSNGRFVFSVEHPICTAYPHGWVRGDDGHKQHWPVDRYRQEGRRDTRWFVDGVVKYHRTVETYVNTLLKAGFTLTHLGEPAPVPDALAVRPDLEAECRRPPVLFLAAVRAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UQ6</accession>
    <name>Q63UQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative beta-ketothiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527148.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108160.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1540"/>
    <dbReference type="EnsemblBacteria" id="CAH35541">
        <property type="protein sequence ID" value="CAH35541"/>
        <property type="gene ID" value="BPSL1540"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1540"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3581"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIWEINE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="394" mass="40883" checksum="4566AE475132517C" modified="2004-10-25" version="1">MQREVVVVSGVRTAIGDFGGSLKDFAPTELGARVVREVLSRAQVSGDEVGHVVFGNVVHTEPKDMYLARVAAINGGIAQHAPALTVNRLCGSGLQAIVSATQNVLLGDADIAVAGGAENMSRAPYSVPAARFGQRMGDAKLVDMMIGALNDPFQSIHMGVTAENVAAKYGITRDAQDALALESHRRASHATKSGYFKDQILPIEIASRKGTVVFDADEHVRHDASLDDFTKLKPVFAKENGTVTAGNASGINDAAAAVVLMERGVADKRGAKPLARLVSYAHAGVDPAYMGIGPVPATKKALERAGITVADLDVIEANEAFAAQACAVSNALGLDPAKVNPNGSGISLGHPIGATGALITVKALYELQRIGGRYALVTMCIGGGQGIAAVFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UU9</accession>
    <name>Q63UU9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trxA</name>
        <name evidence="8" type="ordered locus">BPSL1497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191795.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108117.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1497"/>
    <dbReference type="EnsemblBacteria" id="CAH35498">
        <property type="protein sequence ID" value="CAH35498"/>
        <property type="gene ID" value="BPSL1497"/>
    </dbReference>
    <dbReference type="GeneID" id="56595766"/>
    <dbReference type="KEGG" id="bps:BPSL1497"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3532"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="11815" checksum="6388D320B1ACCB60" modified="2004-10-25" version="1">MSEQIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDENQATPAKFGVRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V32</accession>
    <name>Q63V32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1412"/>
    <dbReference type="EnsemblBacteria" id="CAH35414">
        <property type="protein sequence ID" value="CAH35414"/>
        <property type="gene ID" value="BPSL1412"/>
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    <dbReference type="PATRIC" id="fig|272560.6.peg.1584"/>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="12"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="25363" checksum="12B40E7CCBBE148E" modified="2004-10-25" version="1">MRFMLKITDPIIEVRNVCKRVADAAGELTILAGIDLTVRAGESVAIVGASGSGKSTLLGLLAGLDSATEGTVRLFGQNLGRLDEDARAALRNGAVGFVFQSFQLMPHLSALENVMLPLELQGGVGAREAAQRARALLEEVGLGARTGHYPKLLSGGEQQRVALARAFVTRPALLFADEPTGSLDAATGEAVIDLMFELNRAHGATLVLVTHDTELARRCGATIVLEAGRLRGADRARQEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V63</accession>
    <name>Q63V63_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein (DNA-damage-inducible protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531119.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108003.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1378"/>
    <dbReference type="EnsemblBacteria" id="CAH35378">
        <property type="protein sequence ID" value="CAH35378"/>
        <property type="gene ID" value="BPSL1378"/>
    </dbReference>
    <dbReference type="GeneID" id="56526462"/>
    <dbReference type="KEGG" id="bps:BPSL1378"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.99"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDGIWLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="463" mass="48699" checksum="08B3B2AC3257B077" modified="2004-10-25" version="1">MSASSPPTHADEDPEPRAAANGHRRVLGLALPIIAANLTQPILGAVDTAVAGHLNGPQYLGGVALGGLFFNFVYWGFGFLRMGTTGLVAQAFGANDLAGIRINVLRALLLAFTLGAAVLALQTPLLGIAFAALGGSDSVRSTALEYAHARIWAAPFALANYVVLGYLLGMQRVRLALVIQVLVNVVNIGAVLLYVYRFDWGVAGIGAATATADIAGFAASALLLRWLNPRGLAKIRRVELFDRAALARLVALNRDIFIRTLCLLSAFGWFAHLGARQGDATLAANALLLNFQTFMAYALDGFAHAAEALVGAAAGARNRDAFRQALRTTFFWAGIGALAFALAYWCAGGWIVAQLTDQPSVRGVAERYLPWAALSPVISVWGFMLDGVFIGATHTRALMRAMATSFALFVAATLALVGPLGNHGLWIALLVFMAARGATLARRLPGLERAVAPDAARAPSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD8</accession>
    <name>Q63VD8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL1304B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107928.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35301">
        <property type="protein sequence ID" value="CAH35301"/>
        <property type="gene ID" value="BPSL1304B"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1304B"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1456"/>
    <dbReference type="eggNOG" id="ENOG503172X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSSIMHA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="16270" checksum="1121D39D38145BB4" modified="2004-10-25" version="1">MFQTKSPRPGPHRRAKDPHMKPLRFHSEPIAAPSLHASHASVRDRTAPVRMRAERANPRVLMSIRVGAGNLPHVRRLLHQVLGAALDIYTAVIDNQTGQASLQLELASTSVSDAMTSIMRVLPEAEFGKIRLSPRAPSARAPRMPPRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF5</accession>
    <name>THIC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="1">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="1">HMP-P synthase</shortName>
            <shortName evidence="1">HMP-phosphate synthase</shortName>
            <shortName evidence="1">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiC</name>
        <name type="ordered locus">BPSL1290</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521865.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107911.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VF5"/>
    <dbReference type="SMR" id="Q63VF5"/>
    <dbReference type="STRING" id="272560.BPSL1290"/>
    <dbReference type="EnsemblBacteria" id="CAH35284">
        <property type="protein sequence ID" value="CAH35284"/>
        <property type="gene ID" value="BPSL1290"/>
    </dbReference>
    <dbReference type="GeneID" id="56526568"/>
    <dbReference type="KEGG" id="bps:BPSL1290"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.217"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000242246" description="Phosphomethylpyrimidine synthase">
        <location>
            <begin position="1"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="362"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <sequence length="643" mass="71124" checksum="68CA84692B8E0F55" modified="2004-10-25" version="1">MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPPIYVYDTSGPYTDPDAKIDIRAGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAELRFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRENQRRAEYLESLKASGPNGAKLAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRNFLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWQDQFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIYHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VH4</accession>
    <name>Q63VH4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107892.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1271"/>
    <dbReference type="EnsemblBacteria" id="CAH35265">
        <property type="protein sequence ID" value="CAH35265"/>
        <property type="gene ID" value="BPSL1271"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1271"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1410"/>
    <dbReference type="eggNOG" id="ENOG50316NT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACQKNDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="173" mass="16932" checksum="0A84C21D8FB5F970" modified="2004-10-25" version="1">MCAGASYHRVFATRSRFAAPFAMTTEIAHATAHLRRAGRRPLRAVALAAIAAAALAGCKKPEEASAPPDNAASAAAHAARQTTQKLDQVASFVNQQIEAAKQGVASAASAVPPVTASSVSAAAQGAASAVLGQAATAAGTSLEAAGRKLQQWSQTAALGTSGAAAASGAAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VK2</accession>
    <name>Q63VK2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107864.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1243"/>
    <dbReference type="EnsemblBacteria" id="CAH35237">
        <property type="protein sequence ID" value="CAH35237"/>
        <property type="gene ID" value="BPSL1243"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1243"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1374"/>
    <dbReference type="eggNOG" id="ENOG5032YIV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SEYRAQT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="219" mass="23226" checksum="7358601DF251472B" modified="2004-10-25" version="1">MPGVSIAFISYLQMDSFPASLRLLGALGKLTACAAGLSLVLAAPAFADLLDQRAELVNKYVNEMHADPLVADCAAHGNFIASTSSAFDHVEFAPNAFDSGSASITPWNDSFDEGKQRVKVDNIVTVEGLGVRASGGDPEPLKFRCGYVGTQMLAFSWNDPVPPAKPRVERATSSKKKLRAHSGKGKVKAKATGKSGKRAVSKKSSTTKKAAKKRSTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VP1</accession>
    <name>Q63VP1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 6">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186405.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107825.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1203"/>
    <dbReference type="EnsemblBacteria" id="CAH35198">
        <property type="protein sequence ID" value="CAH35198"/>
        <property type="gene ID" value="BPSL1203"/>
    </dbReference>
    <dbReference type="GeneID" id="56595136"/>
    <dbReference type="KEGG" id="bps:BPSL1203"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.324"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWVFDIH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="22798" checksum="3E17F65EE1EF1D90" modified="2004-10-25" version="1">MNRPKSMLVANIAWARETSERSPDFFDALSRGQNPRVLWIGCADSRVPAEAITQSAPGELFVHRNIANIFQPDDDNCASVLEYAVKVLKVDHVIVCGHYGCGGVRASLLPPSPELPHVNRRIAPLCALAGRHRAELDGVPPDAAADRLAELNVLEQVRLLRSSPIIRDAAPAPLVHGWIFSLADGRLKELASGYPAAQRPPQAERAQAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VP8</accession>
    <name>Q63VP8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvI</name>
        <name evidence="12" type="ordered locus">BPSL1196</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522422.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107818.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1196"/>
    <dbReference type="EnsemblBacteria" id="CAH35191">
        <property type="protein sequence ID" value="CAH35191"/>
        <property type="gene ID" value="BPSL1196"/>
    </dbReference>
    <dbReference type="GeneID" id="56526666"/>
    <dbReference type="KEGG" id="bps:BPSL1196"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.331"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="211"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="410"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH35191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="587" mass="64866" checksum="C2236A6FEF1E9ECD" modified="2004-10-25" version="1">MNMPSAEFSTSESLSPQKTGSIGATVLMKALADENVEFIWGYPGGSVLYIYDELYKQDKIQHVLVRHEQAAVHAADAYSRSTGKVGVCLVTSGPGVTNAVTGIATAYMDSIPLVVISGQVPTAAIGQDAFQECDTVGITRPCVKHNFLVKDVRELAQTVKKAFYIARTGRPGPVLIDIPKDISKTPCEYEPVKNVSLRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGIILADASRELNQFADLLGYPVTNTLMGLGGYRSSDRKFLGMLGMHGTYEANMAMQHCDVLIAIGARFDDRVIGDPAHFASRPRKIIHIDIDPSSISKRVKVDIPIVGDVKEVLKELIEQLQTAEHGPDADALAQWWKEIEGWRGTDCLKYDRASEIIKPQYVVEKLWELTDGNAFVCSDVGQHQMWAAQFYRFNKPRRWINSGGLGTMGFGLPAAMGVKMAHPDDDVVCITGEGSIQMCIQELSTCKQYDTPVKIISLNNRYLGMVRQWQQIEYSKRYSHSYMDALPDFVKLAQAYGHIGMRIEKSADVEPALKEALSLKDRTVFLDFQTDPTENVWPMVQAGKGITEMLLGSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB8</accession>
    <name>Q63WB8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative isoleucine biosynthesis transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ilvR</name>
        <name evidence="4" type="ordered locus">BPSL0970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204927.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107598.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0970"/>
    <dbReference type="EnsemblBacteria" id="CAH34966">
        <property type="protein sequence ID" value="CAH34966"/>
        <property type="gene ID" value="BPSL0970"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0970"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.605"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CECHDSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08453">
        <property type="entry name" value="PBP2_IlvR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037412">
        <property type="entry name" value="IlvR_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="331" mass="34715" checksum="3F2F727BE06052AB" modified="2004-10-25" version="1">MTPDLRQWRYFVAVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVELTAVGAALLPDVRRLIAAADALPPLAQSLARGEAGSLALAFVSTADYGLLPQLLREFGARYPHVRLQLAEATSDVQIEELVAGRIDAGLVIPPVPPRHAASLSYLPVLREPLVVAMPAEAADAADAAADAPVRIADIASLPLVIFPRRLAPGFYDIITGCYGAAGVTPRIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRALADPAPVVETGLVWRTDDVSPVLAGFIGVVRGAARRASPSRPGSTPDAAGEAGAAGAGRRASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WC7</accession>
    <name>Q63WC7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107589.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0961"/>
    <dbReference type="EnsemblBacteria" id="CAH34957">
        <property type="protein sequence ID" value="CAH34957"/>
        <property type="gene ID" value="BPSL0961"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0961"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1042"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QGVSFIT"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="29108" checksum="388E9E91927A3F7F" modified="2004-10-25" version="1">MTPRAASAAPAGTCARRGSMRMGKVYLIGAGPGAADLITVRGARLLEQADVVLHDALVEPAMLDYAPRARRIAVGKRCGQRSSAQHFINKQLVDAAREHAVVVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALASAAALKRSLTLRGVARSVAFATKSRAPGSDEIREQVSADSLVYYMGRDNAPGIARQLIDAGRAGATPVAIVEACSTPRERMLTLTLADMAAGAAQAWLDPAQPSLLMIGDAFAERAPRLADEPPGDAGGKRGMRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WJ3</accession>
    <name>Q63WJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204917.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107523.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0897"/>
    <dbReference type="EnsemblBacteria" id="CAH34890">
        <property type="protein sequence ID" value="CAH34890"/>
        <property type="gene ID" value="BPSL0897"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0897"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.686"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LLPKQWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266398" evidence="5">
        <location>
            <begin position="26"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="430"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="539" mass="58406" checksum="09B0D003C4CBF1F2" modified="2004-10-25" version="1">MLRRHFLSSALAAAAASLFARGAFAAGQAMDGMQGMEGMEGMDDMPDMKPAPAHARHGKPAPGPASALAAADALPAGAPLAALRVLANESREPGVFRATLVAQPVARALLPGAAPTTLWQFGADTQGPAVGPLIDVREGDAVEIRFVNRLPQPSTIHWHGLPVPPDQDGNPSDLVAPGATRVYRFTLPKGSAGTYWYHPHPHMATAEQVFRGLAGPIVVRAADDPLAGWPERHLFVSDLKLARDGAIAPNDMMDWMNGRQGQFALVNGARRPRISLTGDERWRVWNGCSARYLRIAFDDGRPFAHVGTDGGLFDAPREVASLLLAPGERAELVVRAGDRASHAVLTALEYDRGKMAMAMSEAAHGSLPPDPALPLADVAFEPAAPRALPARLRAVPALGEPVARKEVVFGEQMDMAAMMRAGAHGRPAGMRFMVNGVTFEPHRATLTSRRGENESWTIRNETDMDHPFHLHGTQFQVVEREIDGETTPEPYRAWRDTVNVRKGERVRILTTQTERGERMFHCHILEHEDLGMMGTLKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WV3</accession>
    <name>Q63WV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189390.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107413.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0788"/>
    <dbReference type="EnsemblBacteria" id="CAH34780">
        <property type="protein sequence ID" value="CAH34780"/>
        <property type="gene ID" value="BPSL0788"/>
    </dbReference>
    <dbReference type="GeneID" id="56596578"/>
    <dbReference type="KEGG" id="bps:BPSL0788"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.817"/>
    <dbReference type="eggNOG" id="ENOG5032RXQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYFQNGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021332">
        <property type="entry name" value="DUF2944"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11161">
        <property type="entry name" value="DUF2944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="22383" checksum="640D2E9D2E4F1114" modified="2004-10-25" version="1">MDDIVKQALAKWPNVPHCTGWLLLDRRGGWRMRDDAAQAAGALGSPVRHPALVDFIARNYERDEHGQWFFQNGPQRVYVELAYTPWIVRLAAAPAGGGCEPARVALTDHTGRAFEPARAWLDDAGGVLFADTSTPPRVAALHDHDLALFADRADLDDDGAHGVLHLGGGVDLPLEPIRRDDVARRFGFVASPAARAGERAAGGKPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WZ4</accession>
    <name>Q63WZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107372.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0746"/>
    <dbReference type="EnsemblBacteria" id="CAH34738">
        <property type="protein sequence ID" value="CAH34738"/>
        <property type="gene ID" value="BPSL0746"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0746"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.815"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="120" mass="13325" checksum="6EDC4BF5BBA00B32" modified="2004-10-25" version="1">MCISARAFLCVICSNETATHQSVARRHSIFHLGITMYGSTQPRHDKNHRPVPCDTCPQDNPTMLEGYVSDEALALNDCTHIDEMDDGDIRRDGFIEGHCYECNGPDDGDCGDGEDIHEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X03</accession>
    <name>Q63X03_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107363.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0737"/>
    <dbReference type="EnsemblBacteria" id="CAH34729">
        <property type="protein sequence ID" value="CAH34729"/>
        <property type="gene ID" value="BPSL0737"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0737"/>
    <dbReference type="OMA" id="AFFVACV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="105" mass="12043" checksum="38C0B5AD960AAE20" modified="2004-10-25" version="1">MLLTLQDAEGGHGQYRRMLFWCDRVCAVDADRSSDDQLDFLVAFFVACVHPRDWLQDLGVEAGRLHVLFRVPWWGILVRRRNGAVGFLTSRRFSSLFLSMNPEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X46</accession>
    <name>Q63X46_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DeoR family glycerol-3-phosphate regulon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glpR</name>
        <name evidence="6" type="ordered locus">BPSL0691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107320.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0691"/>
    <dbReference type="EnsemblBacteria" id="CAH34684">
        <property type="protein sequence ID" value="CAH34684"/>
        <property type="gene ID" value="BPSL0691"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0691"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.753"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="31337" checksum="A3870F5A44640857" modified="2004-10-25" version="1">MRIRRPRLPSHRAEPTPANMTRDPRLTLNARQQELLEWVQRDGFVTVDDLAAHFNVTPQTIRRDVNWLADLNLLRRYHGGASLPTSSENVSYTARQRMFHDEKRRIAALAASHIPDQASLFINLGTTTEEVARALNRHHGLRVITNNLNVASMMSGYPECEVLITGGIVRPWDKGIVGELAIDFIRQFKVDYAIIGTSSIESDGTLRDFDTREVRVAEAIIQHARTVYLVTDHSKFGRPALVRQGHLSQIHALFTDKPLPDDMAETLVQAGTQVYVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XE2</accession>
    <name>Q63XE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107223.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0594"/>
    <dbReference type="EnsemblBacteria" id="CAH34587">
        <property type="protein sequence ID" value="CAH34587"/>
        <property type="gene ID" value="BPSL0594"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0594"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1039"/>
    <dbReference type="OMA" id="PQMWYPP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="115" mass="12717" checksum="CF1F1E98CD37213C" modified="2004-10-25" version="1">MLVPVTRAYATYTSFSLHLLGTFHVYAEGEKPLTIRNPHLTPQMWYPPGGLAVVGVVGRPRLGPITSYRTPVYSYQGQYQDTIYVQGANGIVTVKVRLLKDEEAESFLDTLDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XK7</accession>
    <name>Q63XK7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase sigma-54 factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpoN</name>
        <name evidence="13" type="ordered locus">BPSL0533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195216.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107158.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0533"/>
    <dbReference type="EnsemblBacteria" id="CAH34522">
        <property type="protein sequence ID" value="CAH34522"/>
        <property type="gene ID" value="BPSL0533"/>
    </dbReference>
    <dbReference type="GeneID" id="56593800"/>
    <dbReference type="KEGG" id="bps:BPSL0533"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1115"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="12">
        <location>
            <begin position="138"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="11">
        <location>
            <begin position="345"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="502" mass="54889" checksum="D7C215AD351B6818" modified="2004-10-25" version="1">MKASLQLRLSQHLALTPQLQQSIRLLQLSTLELQQEVATAIAQNPLLENDDDWIASPLRVAADGSVIAQTPASSAPEPMAGAPNGTAATNERTERDETAGVDEYDSYSADGGDASQWNLDDFGRSPAASDDDDLPPMQIHETSTSLRDHLMAQLRVTQASPRDRALVTFLIESLDDDGYLSASLEEVLADLPAELEVDVDELNAALALVHSFDPAGVGARSASECLKLQLLRLDPSPTRALALDIVSQHLELLAARDFTRLRKQLKATDDALRDAHALIRSLEPFPGAAYGKAEADYVVPDIIVKKAGQNWQAELNPEVVPKLRINNLYANILRNSRGDPSAGSLKQQLQEARWLIKNIQQRFETILRVAQAIVERQKNFFAHGEIAMRPLVLREIADTLGLHESTVSRVTTGKYMLTPFGTLEFKYFFGSHVSTDTGGAASSTAIRALIKQLIGAEDPKSPLSDSRIAELLAEQGFVVARRTVAKYREALKIPAVNLRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XQ3</accession>
    <name>Q63XQ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACP_syn_III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522885.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107112.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0487"/>
    <dbReference type="EnsemblBacteria" id="CAH34476">
        <property type="protein sequence ID" value="CAH34476"/>
        <property type="gene ID" value="BPSL0487"/>
    </dbReference>
    <dbReference type="GeneID" id="56527268"/>
    <dbReference type="KEGG" id="bps:BPSL0487"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1168"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TITHHAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="332" mass="35602" checksum="12C371D46CDB0BE3" modified="2004-10-25" version="1">MRPDQANHWIGIDAAAYELPDAAIEIGAWAARHAWPRAQVDAILESGCRFFHAAPQTSEVELASRAIGALVDSTGIAPSSIDLMVHVHTQTFSMPAPPRSLLYEVAHAHGIRPLWSGSIAQLNCASIAAAIRMIDALFYAYPQAQSALVVSADRAYDEATRLRQFSGIQGDGAGCLLVTRNSRRNRVGGVALHNHAAWYPGSDSANAVERAMISTEWLHTHRIVDAACALTGRPIAHYERILPINTDLRGWHALCRALRVPAERLFGANVARCGHVCCSDFAINLADDGLAALDAGRHVMGVMQSNVGAFAAVALHPLEAASSSTPAEAYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR0</accession>
    <name>Q63XR0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202957.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107105.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0480"/>
    <dbReference type="EnsemblBacteria" id="CAH34469">
        <property type="protein sequence ID" value="CAH34469"/>
        <property type="gene ID" value="BPSL0480"/>
    </dbReference>
    <dbReference type="GeneID" id="56593845"/>
    <dbReference type="KEGG" id="bps:BPSL0480"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1175"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KDWFEQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="59"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="39872" checksum="86E55D085263831A" modified="2004-10-25" version="1">MSEIRDSITFQNAAALKAQARLGPGVICGLRSERAPLPLVVSPHGDSALAADRDAALAWFDARRAAFDALLLEHGGLLLRGFAVPDTHAFRALTDRYPPHAFGYIAGASPRKAIDGNVYESTHLPAPYKLSLHQEKAYMSHYPRLIAFYCRQAAAVGGETPLSDMRAVTRRLPARTLERFRGKGVMYRRNFSAKPMPAHFNQFYRRWQDAFMTDERAEVESLCRATQLEYEWLPDGSLTVTHVGPATVVHPRTGEEVWFNHASTQHINARVVHPTILRALQSFYKTRAALPYDIRYGDGTPMPAEDLDPVYDAIDAEETAFRWREQDVLLLDNILVAHGRNPYSGQRDIQVAMMD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU3</accession>
    <name>GPDA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="1">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsA</name>
        <name type="ordered locus">BPSL0447</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536061.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107072.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XU3"/>
    <dbReference type="SMR" id="Q63XU3"/>
    <dbReference type="STRING" id="272560.BPSL0447"/>
    <dbReference type="EnsemblBacteria" id="CAH34435">
        <property type="protein sequence ID" value="CAH34435"/>
        <property type="gene ID" value="BPSL0447"/>
    </dbReference>
    <dbReference type="GeneID" id="56594476"/>
    <dbReference type="KEGG" id="bps:BPSL0447"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1211"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137937" description="Glycerol-3-phosphate dehydrogenase [NAD(P)+]">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <sequence length="332" mass="34364" checksum="20394DDAA473216F" modified="2004-10-25" version="1">MKVAVLGAGAWGTALAAHLAVRHDTLLWARDAALVAELAARRENARYLGGVALPPGLRYEADLATALSHAQADDALCVIAAPVAGLRALCRAMRDARRVPAHFVWVCKGFEADTRRLPHQMVAEELPDHASYGVLSGPSFAREVAQGLPVALTVASASAACRERTLAAFHHGAMRIYTGDDVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALVTRGLAEMSRLGVALGGRAETFTGLTGLGDLILTATGDLSRNRSVGLQLAAGRSLDDILAALGHVAEGVRCARAVLSIARERGVDMPITEAVCAVLFDGVAPRDAVSGLLRRDAKAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU4</accession>
    <name>SECB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-export protein SecB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secB</name>
        <name type="ordered locus">BPSL0446</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198004.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107071.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XU4"/>
    <dbReference type="SMR" id="Q63XU4"/>
    <dbReference type="STRING" id="272560.BPSL0446"/>
    <dbReference type="EnsemblBacteria" id="CAH34434">
        <property type="protein sequence ID" value="CAH34434"/>
        <property type="gene ID" value="BPSL0446"/>
    </dbReference>
    <dbReference type="GeneID" id="56594475"/>
    <dbReference type="KEGG" id="bps:BPSL0446"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1212"/>
    <dbReference type="eggNOG" id="COG1952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPNVLFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00821">
        <property type="entry name" value="SecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003708">
        <property type="entry name" value="SecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035958">
        <property type="entry name" value="SecB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36918">
        <property type="entry name" value="PTHR36918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02556">
        <property type="entry name" value="SecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01594">
        <property type="entry name" value="SECBCHAPRONE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54611">
        <property type="entry name" value="SSF54611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00809">
        <property type="entry name" value="secB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000055359" description="Protein-export protein SecB">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00821"/>
        </source>
    </evidence>
    <sequence length="159" mass="17671" checksum="644CA625D3A700CB" modified="2004-10-25" version="1">MSDVENQPFFNIQRIYLKDLSLEQPNSPAIFLEQEMPAVEVEVDVKAERLAENVYEIVVAGTVTAKVREKVAFLVEAKQAGIFDIRNIPAEQIDPLCGIACPTILFPYLRSNIADSITRAGFPPIHLAEINFQALYEQRLAEISQQQQQGGAPNGTTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XZ7</accession>
    <name>Q63XZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536085.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107018.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0392"/>
    <dbReference type="EnsemblBacteria" id="CAH34380">
        <property type="protein sequence ID" value="CAH34380"/>
        <property type="gene ID" value="BPSL0392"/>
    </dbReference>
    <dbReference type="GeneID" id="56527364"/>
    <dbReference type="KEGG" id="bps:BPSL0392"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1274"/>
    <dbReference type="eggNOG" id="ENOG5030V4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KAVQFWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="263" mass="26477" checksum="A76FFE5A88B604AD" modified="2004-10-25" version="1">MTDPNGSNPFSGFGGFQPAGFLDKMWDMMRLTPFGAMSALPGASQGLPPSLSAMSDLMAPLASVEELDKRITDLRAVEQWLKLNLGMLQSAIQALEVQRATLATLRAFGALAQTSMAAAEAALSPDDSAPREPASAAASASAAKREASAGEPADAQGARDADGETPPPGADAFDPAGWWNLLQSQFNQLARFAMTQPGMAAAGDAPAAGAAAGPKPSAAKKPAPRRAAAPRTGGSAADRAPGASSAGGDAKPAAAKKPARRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y83</accession>
    <name>Q63Y83_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106932.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0305"/>
    <dbReference type="EnsemblBacteria" id="CAH34294">
        <property type="protein sequence ID" value="CAH34294"/>
        <property type="gene ID" value="BPSL0305"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0305"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.335"/>
    <dbReference type="eggNOG" id="COG3762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWESTRD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TPM_phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="166" mass="18706" checksum="E29E6ACA39DDE9F0" modified="2004-10-25" version="1">MMDIARIARHLSMTRWRVAAAFPKRTLGKIERAIEASHEKHVGQLRFAVEGALHASMLLRGITARERAIDVFSELRVWDTEHNNGVLIYLLLADHDVEIVADRGIHARVDGDEWERVCRAMEAQFRRGRFEAGSIHGIEAVTALLARHYPSRRAPGGAWPSTPVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YC4</accession>
    <name>Q63YC4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106891.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0264"/>
    <dbReference type="EnsemblBacteria" id="CAH34252">
        <property type="protein sequence ID" value="CAH34252"/>
        <property type="gene ID" value="BPSL0264"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0264"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.283"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPMNIEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="23893" checksum="21E0B02BC9E3EB43" modified="2004-10-25" version="1">MNPMKLVIGDKNYSSWSMRPWVLMKHFGIPFDEVMIGLRLDDTAERIRAHSPSGKVPCLVDDEGGSVWDSLAIVETLAERFPQHALWPRDPAARAHARSVSAEMHAGFPALRSEMPLNVRESHPGRGATPAALADVARIDELWRTCVAASGGPFLFGAFSIADAMYAPVVLRFKTYAPPLSPEASAYAARVAELPAVREWIDGARGETRVIDIYGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK2</accession>
    <name>Q63YK2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189331.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106813.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63YK2"/>
    <dbReference type="STRING" id="272560.BPSL0185"/>
    <dbReference type="EnsemblBacteria" id="CAH34172">
        <property type="protein sequence ID" value="CAH34172"/>
        <property type="gene ID" value="BPSL0185"/>
    </dbReference>
    <dbReference type="GeneID" id="56596693"/>
    <dbReference type="KEGG" id="bps:BPSL0185"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1534"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="357" mass="37363" checksum="EC485D32AEEEAE00" modified="2004-10-25" version="1">MEYSPPPLFKQGPSALARLIFFVVLAIALLVSDARFNTLEIVRGVLGTVLYPLQRAALVPRDLIVGAAELATSSTALRHENQQLRDRNLKLSLQANQAGQLAADNAHLRAVLELRQQIAAQATPVEIQYDTGDPFSQKIIIGHGSQAGIQDGAPVVNEDGVIGQVTRVFPLQSEVTLVTDRDLAIPVQVLRTGLRSVIYGTPKGDALDLRFVPTSADLLAGDELVTSGLDGVYPPGLPVAKVVRVDKLADTAFAHVVCAPIAAVRGAREMLVLHYRNDIPPPPVTDDAASDAKAAKGKKATKGADKSAKAADKGADKDKGAKPAAAPPVPARSRPAGPAQPAAPLKPATAPSPGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR8</accession>
    <name>Q63YR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009935893.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106747.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0120"/>
    <dbReference type="EnsemblBacteria" id="CAH34106">
        <property type="protein sequence ID" value="CAH34106"/>
        <property type="gene ID" value="BPSL0120"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0120"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1603"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SEMPFGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="40455" checksum="F0AD43AC79633AAD" modified="2004-10-25" version="1">MSPRALTRAELSGWLRLAGASGVPAAACAALLGAFASLEALFAASHAELAAIVGDAAAQSVLAPPAADFEQRVDAALAWLDEPGNALVTRHDPAYPGPLAELYDPPPLLYIKGRVALLHARAVAIVGSRGATPQGLADATRFARELSDAGLAIVSGLARGIDGAAHRGGLDGASGTVAVIGTGADLVYPACHHALAHEIAERGALVSEWPLGTPARSAHFPQRNRLIAALSGGVLIVEAALRSGSLITARLANEMGRDVFAIPGSIHAPLSQGCHALIRDGAKLVETAADVLDEFGLDPARPVNSKRGAPTAASADADLDDDTRRLLDAIGYGPVPLELLAQRTSLPSGTLHRLLLQLELAGRVAALPGGRYTRIDGAQAEPAQARGTSAVLHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YX3</accession>
    <name>Q63YX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009935860.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106692.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34050">
        <property type="protein sequence ID" value="CAH34050"/>
        <property type="gene ID" value="BPSL0067"/>
    </dbReference>
    <dbReference type="GeneID" id="56594157"/>
    <dbReference type="KEGG" id="bps:BPSL0067"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1671"/>
    <dbReference type="eggNOG" id="ENOG5033VKQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HERTIRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="15629" checksum="F7C688BCC6E0AF09" modified="2004-10-25" version="1">MPYVSTHYSNNASAPVGRWTCAPTSKLAPFDKAPTGSVTSGVDLCGQCVSYVKRVCPTLPLTGQWRKGAPVKGNATIVAGTVIATFNAAGKYDGHAAIYVSQTKDGGILVYDQFVTPPTPQPVRQRRLRWGAHGRSNNGDNFYVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YY8</accession>
    <name>Q63YY8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535633.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106677.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0052"/>
    <dbReference type="EnsemblBacteria" id="CAH34035">
        <property type="protein sequence ID" value="CAH34035"/>
        <property type="gene ID" value="BPSL0052"/>
    </dbReference>
    <dbReference type="GeneID" id="56527670"/>
    <dbReference type="KEGG" id="bps:BPSL0052"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1691"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SGVYKET"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="14624" checksum="AB59D04B213FC747" modified="2004-10-25" version="1">MRTPYQIVADHYAASDRRDPAAMMADIAPTIEWTEMAGFPCAGTYRSADEIVRNVFRRLGEEWDGYTFALDALHDAGDTVIGIGRYSGIYRRTGKSFACRVAHVWRVDAGKIVRFEQFTDTLLVAQAMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z13</accession>
    <name>Q63Z13_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LrgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106649.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0024"/>
    <dbReference type="EnsemblBacteria" id="CAH34007">
        <property type="protein sequence ID" value="CAH34007"/>
        <property type="gene ID" value="BPSL0024"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0024"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.24"/>
    <dbReference type="eggNOG" id="COG1380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWVRAGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="132" mass="13931" checksum="199AB5B398537E94" modified="2004-10-25" version="1">MARIALQTAALGALWAAIDWTVRAFGVPVPSGVVGLAVLLALLLSGRVAPGWVKDGANWLLSDMLLFFIPATVAAVQYGGLFKADGWRLALVVVAGTTFVMLSVAIAVDVAAGFERRLAVMRVRAGRRRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z31</accession>
    <name>Q63Z31_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524535.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106631.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0006"/>
    <dbReference type="EnsemblBacteria" id="CAH33989">
        <property type="protein sequence ID" value="CAH33989"/>
        <property type="gene ID" value="BPSL0006"/>
    </dbReference>
    <dbReference type="GeneID" id="56527716"/>
    <dbReference type="KEGG" id="bps:BPSL0006"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1743"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGNTWRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266876" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="18135" checksum="379ED557424EE7C4" modified="2004-10-25" version="1">MEKRFVIVAMFAAGAWFASAPARADCYDEAAKYQKVNPLVLRAIAWQESHNRPEALNKNANGSTDYGLMQINSIHLPTLSRYGITKDTLMEPCKSVYIAAWHLRRKMDKYGNTWQAIGAYHSETPSLRDKYARQIADILARWKLLPASAASATQDTQSAQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-29" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RGS8</accession>
    <accession>Q63SC1</accession>
    <name>PHLN_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>Non-hemolytic phospholipase C</fullName>
            <ecNumber>3.1.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>PLC-N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphatidylcholine cholinephosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphatidylcholine-hydrolyzing phospholipase C</fullName>
            <shortName>PC-PLC</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">plcN</name>
        <name type="ordered locus">BPSL2403</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="J. Clin. Microbiol." volume="37" first="3742" last="3745">
            <title>Cloning and characterization of a nonhemolytic phospholipase C gene from Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Korbsrisate S."/>
                <person name="Suwanasai N."/>
                <person name="Leelaporn A."/>
                <person name="Ezaki T."/>
                <person name="Kawamura Y."/>
                <person name="Sarasombath S."/>
            </authorList>
            <dbReference type="PubMed" id="10523590"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>CHARACTERIZATION</scope>
        <source>
            <strain>SPT1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Hydrolyzes phosphatidylserine as well as phosphatidylcholine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text>Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3"/>
    <dbReference type="EMBL" id="AF107252">
        <property type="protein sequence ID" value="AAF17299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527449.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108995.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RGS8"/>
    <dbReference type="SMR" id="Q9RGS8"/>
    <dbReference type="STRING" id="272560.BPSL2403"/>
    <dbReference type="EnsemblBacteria" id="CAH36406">
        <property type="protein sequence ID" value="CAH36406"/>
        <property type="gene ID" value="BPSL2403"/>
    </dbReference>
    <dbReference type="GeneID" id="56528784"/>
    <dbReference type="KEGG" id="bps:BPSL2403"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2993"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YHCSFIG"/>
    <dbReference type="BRENDA" id="3.1.4.3">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" description="Tat-type signal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000023940" description="Non-hemolytic phospholipase C">
        <location>
            <begin position="35"/>
            <end position="700"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <variation>T</variation>
        <location>
            <position position="80"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="86"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="124"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="151"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="254"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
        <original>E</original>
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        <location>
            <position position="369"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="383"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="387"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="436"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="548"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="574"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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            <position position="627"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
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        <location>
            <position position="633"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
        <original>NAA</original>
        <variation>KES</variation>
        <location>
            <begin position="638"/>
            <end position="640"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
        <original>S</original>
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        <location>
            <position position="668"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAF17299." evidence="2" ref="1">
        <original>A</original>
        <variation>V</variation>
        <location>
            <position position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="700" mass="77077" checksum="9F7F4FB478ACFFD2" modified="2004-11-23" version="2" precursor="true">MTNQNRRDFLRLAAGTAGAAALQLFPPVIREALAIPANRRTGTIRDVEHIVILMQENRSFDHYFGKLRGVRGFGDPRPLALQNGKSVFHQPVLLGPAELLPFHPDASNLGMQFLQDLPHGWQDMHGAWNKGRYDRWIANKGTTTMAYLERDDIPFHYQLADAFTICDAYHCSIPSSTDPNRYYMWTGYVGNDGAGGGPVLGNEEAGYGWSTYPETLEQAGVSWKIYQDIGTGLDAAGSWGWTQNPYIGNYGDNSLLYFNQYRNAQPGSPLYDKARTGTNVSAGGTLFDVLQQDVKNGTLPQVSWICAPEAYSEHPNWPANYGAWYVEQVLKALTSNPDVWSKTALFITYDENDGFFDHVAPPFAPQSRENGLSTVSTAGEIFAGDATHMAGPYGLGPRVPMLVVSPWTKGGWVCSQTFDHTSLLQFIEARFNDRYSVRAPNVTPWRRAVCGDLTSAFNFSSPDGSWPQLPDTSGYAPPDRNRHPSYVPVPPAAQSMPKQEAGLRAARALPYELFVLGRIDQSTGKFKLTFANTGRAGAAFQVTAGNRLDGPWAYTVEARKRLSDEWSTALTLSIYDLTVYGPNGFLCQFRGSTAAALGLSANPEVIYGYDVANGNITLRLSNRGRAAVRLTVTNAYGNAAPRVYELKPGQRINDYWDLRDSHSWYDLSVSDGAPNGFLRRFAGHVETGRPSTSDPLIATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>H7C745</accession>
    <name>H7C745_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">wcbL</name>
        <name evidence="6" type="ordered locus">BPSL2796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">K96243</strain>
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    </reference>
    <reference evidence="8 9 10" key="2">
        <citation type="journal article" date="2015" name="Chem. Biol." volume="22" first="1622" last="1632">
            <title>Unraveling the B.pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.</title>
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                <person name="Vivoli M."/>
                <person name="Isupov M.N."/>
                <person name="Nicholas R."/>
                <person name="Hill A."/>
                <person name="Scott A.E."/>
                <person name="Kosma P."/>
                <person name="Prior J.L."/>
                <person name="Harmer N.J."/>
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            <dbReference type="PubMed" id="26687481"/>
            <dbReference type="DOI" id="10.1016/J.CHEMBIOL.2015.10.015"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH ATP ANALOG; MAGNESIUM AND MANNOSE</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
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        <property type="chains" value="A/B=1-346"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.82 A"/>
        <property type="chains" value="A/B=1-346"/>
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        <property type="resolution" value="1.94 A"/>
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    <dbReference type="PATRIC" id="fig|272560.51.peg.2512"/>
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    <dbReference type="OMA" id="LEIHHDG"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Galkinase"/>
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        <property type="entry name" value="GHMP_kinase_C_dom"/>
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        <property type="entry name" value="GHMP_kinase_C_sf"/>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
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        <property type="entry name" value="LMBPPROTEIN"/>
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        <location>
            <begin position="108"/>
            <end position="171"/>
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        <location>
            <begin position="245"/>
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        <location>
            <position position="13"/>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
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    <feature type="binding site" evidence="11">
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        <ligand>
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    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="4UT4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="4UTG"/>
        </source>
    </evidence>
    <sequence length="346" mass="37977" checksum="1D285DB39522D1CD" modified="2012-04-18" version="1">MNPTIIRARAPLRLGLAGGGTDVAPYADTFGGYVLNATIDRYAYAVIKTLTIPAVRFVSTDQQVEKHQLISEPLELNGTLNLHKAVYNHMIRNYNHGKPIALELSTFCDAPAGSGLGSSSTLVVVMIKAFVELLNLPLDDYAIAQLAYRIERVDCGLAGGRQDQYSATFGGFNFMEFYEEERTIVNPLRIKNWVLCELEASLVLFYTGVSRESAKIIQDQSDNVVSHKTAAIEAMHGIKREALVMKEALLKGDFKAFVASMRLGWDNKKNSARTVSNAHIDEIYDAAIRAGAQAGKVSGAGGGGFMLFFVPTEKRMDLIRTLGEYDGQVSNCHFTKNGTQAWRIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV7</accession>
    <name>Q63HV7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187957.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112315.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2312"/>
    <dbReference type="EnsemblBacteria" id="CAH39798">
        <property type="protein sequence ID" value="CAH39798"/>
        <property type="gene ID" value="BPSS2312"/>
    </dbReference>
    <dbReference type="GeneID" id="56598421"/>
    <dbReference type="KEGG" id="bps:BPSS2312"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5943"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRVGHAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="231"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="477" mass="51221" checksum="6C428A2447886CE7" modified="2004-10-25" version="1">MIDERWARAARELRCDAGFWSLRVVDERVDEHAVRNDVAQPLSSARDRGAMLVAWCGAGAGYAATADLSPAGLQAALDVAAARAKASAALSLIDHRAVARPDASGGYVSPHADDALPGRAEWLERLARECAAAAVDARIVERTAAVMLVQTDQLYMTSDGVRIEQRFRHVMPQLSVVAHARGDTQVRTLGNAGTLAQGGVDVLARYGFEGAGARVADEALQLLAAPNCPSGRRDLLLMPDQMMLQIHESIGHPLELDRILGDERNFAGWSFVKPEMFGAYPYGSPLLNVTFDPTLPGEAASYAFDDDGAAARKQYLIRNGVLERPLGGALSQARAGLPGVANARASSWNRPPIDRMANLNVEPGAHTFGELVAGIERGILMRTNTSWSIDDHRNKFQFGCEFGQLIENGELTQVVKRPNYRGISASFWRSLRAVGDASTFGVYGTPYCGKGEPAQIVRVGHASPACVFADVDVFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HY1</accession>
    <name>Q63HY1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529498.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112291.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63HY1"/>
    <dbReference type="STRING" id="272560.BPSS2288"/>
    <dbReference type="EnsemblBacteria" id="CAH39774">
        <property type="protein sequence ID" value="CAH39774"/>
        <property type="gene ID" value="BPSS2288"/>
    </dbReference>
    <dbReference type="GeneID" id="56531621"/>
    <dbReference type="KEGG" id="bps:BPSS2288"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5908"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DESAQWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="16026" checksum="1E4FBA584B361126" modified="2004-10-25" version="1">MSNVTRYDPFSLEPVSDLFQGLFRPLRGIADADDEKLASMKIDVTENDQAYAVKAELPGVDKNDINVQIDGNTVSISAKVERNKELKEGERVIRRERYSGEFARTFSLANELDRDAASAQYQDGVLSLTLPKKASSEKKKLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I09</accession>
    <name>Q63I09_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112263.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2260"/>
    <dbReference type="EnsemblBacteria" id="CAH39746">
        <property type="protein sequence ID" value="CAH39746"/>
        <property type="gene ID" value="BPSS2260"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2260"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5863"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGSEWSE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="39327" checksum="145CB9D69A059F96" modified="2004-10-25" version="1">MQRRYQGRPVGRGGAAGWQERNERGLRGGERGMQYDDEALLRPDLDVEGDYRMLAEDIGPEDWGSDWADWDDRNPYDERRRGYEGGRREREGGRGPQRMRGVGAQGNVGEARGGYAGPRGYGDDGWYQGGGRDDDGDLRKFRGQSRLVAGSRSPYRGGEREERAGPEPWRAGGERSAYRDELWSPYRTREYDRSRDYRDLLHGGGGQREMLHRQGPKGYTRSDERIREDICERLAYAFDLDVSDVSVEVNGGRVELQGTVPERWMKHEIEDIADNCMCVRDVDNRVRVLPRERGETTGTAGMAAPPEGQPMRPEHRTSTMAGGAGGAGGQSPGGSVAGGQPSGALSGTGGHDPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I34</accession>
    <name>Q63I34_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205751.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112238.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2235"/>
    <dbReference type="EnsemblBacteria" id="CAH39721">
        <property type="protein sequence ID" value="CAH39721"/>
        <property type="gene ID" value="BPSS2235"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2235"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5832"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CCRNFGT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="196"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="391" mass="41289" checksum="89134B2BB4B0E114" modified="2004-10-25" version="1">MKALCWHGKHTVRYETVADPAVEDPRDAIVEVRACSIGGADLHLYDAVIPGLKDGDVLGRECVGEVVEIGAGVSRRRVGERVVVPFAIACGECDQCRRGNWSVCETTNPHRALADKVFGHATGGLLGCGHLAGGYPGGQAQYVRVPHADVAPATIPDGVDDERALFVGDSLATGWQAAAQCEIEPGNVVAVWGAGAVGLFAAMSARLLGAAEVIAIDRVPERLALAQKLGATPLDFERLGVADTLAERTRGKGPDKCIDAVGLEAQAGEALDAVTDRFRPTVAAGADQPHVLREMIYACRPGGVLSVPGVYGGLVDKLPMGALMHKGLTLRAGQTHVCRWTAGLLERIADGRLDPSCVITHRATLEEGPAMYETFGARRDGCIRPVLRPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I35</accession>
    <name>Q63I35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transport related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205750.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112237.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2234"/>
    <dbReference type="EnsemblBacteria" id="CAH39720">
        <property type="protein sequence ID" value="CAH39720"/>
        <property type="gene ID" value="BPSS2234"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2234"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5831"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITMHSYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="484" mass="51069" checksum="2182FFC97A5730BC" modified="2004-10-25" version="1">MDELRSQRRAERAARNEHAGGAPPGAAARRAGNACDKPDAHGAHDAHDAYGSCDEPGADGRRRARAAPWYRRLGPGLLTGASDDDPSGIATYAQAGSQFGFAMLWLTVVTLPLMVAVQLASAHVGRGDREGLIAAIRRYYGAPLAKTLVVLVALVNVANVGADLSAMGDATALLVGGKSYWFALAYGAGMFALQVRLPYPRYARYLKWLSIALFAYVIEVALVDVDWAAVAHALVAPRIAFSHEYATTAVAVLGTTISPYLFVWQAALEVEEIAQERRAGTSAGASRKSSTSRGQGRRILIDTWVGMLASNVVAFCIMLTASAVFFAHGVHDIATTRQAAKTLEPIAGRAAFLLFACGIVVSGLLAIPAFASSAAYGFAEAWRFRASMNAPLARAPLFYAVIGACLAVGVALCFSPINPIKALYWSAVLNGVAAVPMLAMVMRLASRRDVVGRLTNGIVLNTLGWSATALMAVAVGVMVFDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I41</accession>
    <name>Q63I41_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523330.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112231.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39714">
        <property type="protein sequence ID" value="CAH39714"/>
        <property type="gene ID" value="BPSS2228"/>
    </dbReference>
    <dbReference type="GeneID" id="56531681"/>
    <dbReference type="KEGG" id="bps:BPSS2228"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5823"/>
    <dbReference type="eggNOG" id="ENOG5032X34">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRHDAMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023107">
        <property type="entry name" value="Atu2299-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="214" mass="24504" checksum="FE4B24EC91E42FC8" modified="2004-10-25" version="1">MHHEPETSPPILAAPIRAALHPVIDEVVHRSVSEATTKDGYMRCADYAIVGARVLSMLTGVRYRPVAGGEVMDFGGGNLFALCSTRERRRAARHLSQLARYHCWIEARHTDADGRARTEVIDFTMRHDARVASMVGMPFTGSRGTYWWGWDDEHIVPAELRDHPAFAKQGPRWRWAERECTVLLRAYERERPNYFGRQVSRALHLLADRIERDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I75</accession>
    <name>Q63I75_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pilus assembly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2012-01" db="PDB data bank">
            <title>Crystal structure of a Putative pilus assembly-related protein (BPSS2195) from Burkholderia pseudomallei K96243 at 2.50 A resolution (PSI Community Target, Shapiro L.).</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1-127</scope>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523366.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112197.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="4DAD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A=1-127"/>
    </dbReference>
    <dbReference type="PDBsum" id="4DAD"/>
    <dbReference type="SMR" id="Q63I75"/>
    <dbReference type="STRING" id="272560.BPSS2195"/>
    <dbReference type="EnsemblBacteria" id="CAH39680">
        <property type="protein sequence ID" value="CAH39680"/>
        <property type="gene ID" value="BPSS2195"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2195"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5778"/>
    <dbReference type="eggNOG" id="COG4565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRATMEE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4DAD"/>
        </source>
    </evidence>
    <sequence length="402" mass="43457" checksum="984C476D559BF6BE" modified="2004-10-25" version="1">MINILVASEDASRLAHLARLVGDAGRYRVTRTVGRAAQIVQRTDGLDAFDILMIDGAALDTAELAAIEKLSRLHPGLTCLLVTTDASSQTLLDAMRAGVRDVLRWPLEPRALDDALKRAAAQCAQRDTPDTRIVSFMSCKGGAGTSFIAGNIAYEIAEGSKRRTLLIDLNQQFADAAFLVSDQTPPSSVAQLCGQLERLDGAFLDASVVRVTDTFHVLAGAGDPIKAADIREDALEWILGVAAPRYDFVIFDLGVSLNAVSMVALDRSDHIEVVLQPSMPHVRAARRLQELLVSLGCPPERIQLVLNRQTRASERARAALEEVLSTRAAHVIADDPATVNEAVDQGVPLSRLSRNCGVARSLQAFARQLAEGEQRPRRDSARDAPLLARFFSRGAAPKLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ID5</accession>
    <name>Q63ID5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family S43 non-peptidase homologue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112137.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2136"/>
    <dbReference type="EnsemblBacteria" id="CAH39619">
        <property type="protein sequence ID" value="CAH39619"/>
        <property type="gene ID" value="BPSS2136"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2136"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6541"/>
    <dbReference type="eggNOG" id="ENOG502ZRJ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGNEYFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005318">
        <property type="entry name" value="OM_porin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34596">
        <property type="entry name" value="PTHR34596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03573">
        <property type="entry name" value="OprD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266465" evidence="2">
        <location>
            <begin position="26"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="480" mass="51613" checksum="4D92E48DC7740D8A" modified="2004-10-25" version="1">MKRVARAVVLAWGLPMLAGVSIAGAARADDAAPAAPAQAPLAATLAQQATTPNALVNADATQAVLPQPPMSSQAKSKGFIADSHFDVLLRNYADVLDAKGGPHRHAWVQGVMANFESGYTGGLIGFGVDASIYAALKLDGGAGGGNMVHVAKGGGGSNQLAWAFPGIYDVKARISNTVIKYGLQAVDNPFMEQHDNRALPPTFLGATIVSNEFKNVMLEAGSFTKTNARGHTTLTNLTTQYGGTRVDRFTYVGGTWDYSQTGSASFYAGQADDVWRQYYGSVKQSYGSPQTVKWTGFGNFYSTHDTGDARQGKIDNNAYSLSLAAQHGPHELLLGYQQVLGDQFFDYLNETNGIFLVDSMDVDYNAPHEKSLQLRYTFYGKEAGLPGFKAMVWGVTGWGADGSASAALDPTRSSIYWKDGAPVQGRHHEFGFIPSYTIQSGKLKDTKITFIAMWHVGSAHYSDSTNQEYRLVVNVPVKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IE4</accession>
    <name>Q63IE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266659.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112128.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2129"/>
    <dbReference type="EnsemblBacteria" id="CAH39610">
        <property type="protein sequence ID" value="CAH39610"/>
        <property type="gene ID" value="BPSS2129"/>
    </dbReference>
    <dbReference type="GeneID" id="56598152"/>
    <dbReference type="KEGG" id="bps:BPSS2129"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6524"/>
    <dbReference type="eggNOG" id="ENOG5030V19">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYQWTTR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="20479" checksum="CE56A49FE0EECA52" modified="2004-10-25" version="1">MDVMAKLLTDLEFQRFSELQQKQASFTITPEEADELRDIVARAQKKRDDRASAMRAIEAYIAQFDITPDELFSPEQIGEAARTYGLIAAGKKERSLPPSLTFNGKPYQWTKTLPDEVRLPLFDAFKAGESIKRFIAMPKDAARCALTVARLERETGAVYADTLLDELAISRKHVEEAAAKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF9</accession>
    <name>Q63IF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552203.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112113.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2115"/>
    <dbReference type="EnsemblBacteria" id="CAH39595">
        <property type="protein sequence ID" value="CAH39595"/>
        <property type="gene ID" value="BPSS2115"/>
    </dbReference>
    <dbReference type="GeneID" id="56531790"/>
    <dbReference type="KEGG" id="bps:BPSS2115"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5661"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PTFASKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="32919" checksum="A1153111B55AAD8B" modified="2004-10-25" version="1">MPARKPGRLPPLNALRAFEVSARHLNFRAAADEIGVTQGAVAQQVRHLEDALGVALFERLPRGLALTADGLAYFADVRRALNLIGDATDRLAKRRANVTISTTPSFASRWLIPRLASFGDEHPGVDLRVIADSQFATFQGDGVDLAIRYGKPPFGKGLVTRLLFPVDIYAVCSPALLATPGVLARARDLAGHALLHDAHDLWPEFLAALPERVAIDPAKGPRFNQSSLAIDAAIAGHGVALASDQLVARDIEAGRLRRLFDFALPLSVGYYIVRPSEPRRPGDIAQTEAWLIRQAQLDARRDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IK1</accession>
    <name>Q63IK1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009969404.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112071.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2068"/>
    <dbReference type="EnsemblBacteria" id="CAH39548">
        <property type="protein sequence ID" value="CAH39548"/>
        <property type="gene ID" value="BPSS2068"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2068"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5613"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDGYVPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="27452" checksum="D074D6448F016FC1" modified="2004-10-25" version="1">MNASAQLASRRVLLTGGLGSLGQAQVRKLRAAGADVYILDLPSPRGDELAEALNSETGAGMGHVTFVPADLRELASAQALVSDLGHEIGGFDILINNAALITHKPYDEFTLSEYEDVMRVNSTAGFALTQAVTPMMKANGWGRIINFCSITLNGRWEKYVPYVSSKGAMLGQTKTFARALGPFGITVNAVSPGAIVSDAEERVFGDKLKEYNDWVLENQSLKRRGEPEDVANLVAFLASDQASFLTGQIISLDGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IU3</accession>
    <name>Q63IU3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sedolisin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552117.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111979.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1973"/>
    <dbReference type="EnsemblBacteria" id="CAH39451">
        <property type="protein sequence ID" value="CAH39451"/>
        <property type="gene ID" value="BPSS1973"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1973"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5474"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TTTWAGE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266309" evidence="7">
        <location>
            <begin position="36"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="8">
        <location>
            <begin position="252"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="644" mass="66606" checksum="55D2B0AAE7502333" modified="2004-10-25" version="1">MQRTQHVNRLFSKRFALSPLPLAIAVALSPLLAHAAPDWVPTRTDAFLIARAPAAAASQTLAKTAPSYALNMIGTPELADTNVTPLELSQPLRVTIVLKSRNEAQLDSLVREVNQPGSANYRKYLTPEQFKARFAPTDAQVRAVVAHLKANGFGDITVSANNKLIFAQGNASNAEHGFHTTLKRFSYRGKAVYANDSAALVPASLSPVVESVLGLQSAAVPHRLIHRGTPADARIQTDAITKNATASGTQTGHQPTDFAQIYNASGLPAATNTTVGIITWGDMTQTIADLNTFTRNAGLPNVNTAVVAGSSGTLADDGDPGEWDLDSQTIIGTSGGVKQLIFYAAVNGDSNDSGLTNATLTAAYNKAVTDNVAKVINVSLGEDEAAANSDGSLAANDAVFKQAVAQGQIFSVSSGDAGVYQWSTSPYGAPGYVGTYSGGKVTTKINLAKYSVSSPASSPYVVAVGGTTLSTSGTTTWAGETVWNEGLAYADVSSSGQPLDNAVRLWATGGGVSGYEAAPSWQTAALGSSVTKRVVPDVAFDAAQSTGAYLVINGQPNQLVGGTSLASPIFVGGWARVESANGNGLGLPTSAFYQGLPGNPSLVHDVTSGNNGYNSYGYSAKSGWDDDTGFGSLDFAKVSASSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J95</accession>
    <name>Q63J95_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fbp</name>
        <name evidence="6" type="ordered locus">BPSS1823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="2">
        <citation type="journal article" date="2011" name="Biochem. J." volume="437" first="413" last="422">
            <title>The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.</title>
            <authorList>
                <person name="Norville I.H."/>
                <person name="O'Shea K."/>
                <person name="Sarkar-Tyson M."/>
                <person name="Zheng S."/>
                <person name="Titball R.W."/>
                <person name="Varani G."/>
                <person name="Harmer N.J."/>
            </authorList>
            <dbReference type="PubMed" id="21574961"/>
            <dbReference type="DOI" id="10.1042/BJ20110345"/>
        </citation>
        <scope>STRUCTURE BY NMR</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2014" name="Antimicrob. Agents Chemother." volume="58" first="1458" last="1467">
            <title>A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.</title>
            <authorList>
                <person name="Begley D.W."/>
                <person name="Fox D."/>
                <person name="Jenner D."/>
                <person name="Juli C."/>
                <person name="Pierce P.G."/>
                <person name="Abendroth J."/>
                <person name="Muruthi M."/>
                <person name="Safford K."/>
                <person name="Anderson V."/>
                <person name="Atkins K."/>
                <person name="Barnes S.R."/>
                <person name="Moen S.O."/>
                <person name="Raymond A.C."/>
                <person name="Stacy R."/>
                <person name="Myler P.J."/>
                <person name="Staker B.L."/>
                <person name="Harmer N.J."/>
                <person name="Norville I.H."/>
                <person name="Holzgrabe U."/>
                <person name="Sarkar-Tyson M."/>
                <person name="Edwards T.E."/>
                <person name="Lorimer D.D."/>
            </authorList>
            <dbReference type="PubMed" id="24366729"/>
            <dbReference type="DOI" id="10.1128/AAC.01875-13"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 2-113</scope>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2017-03" db="PDB data bank">
            <title>Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354.</title>
            <authorList>
                <person name="Lorimer D.D."/>
                <person name="Dranow D.M."/>
                <person name="Seufert F."/>
                <person name="Abendroth J."/>
                <person name="Holzgrabe U."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-113</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525093.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111827.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="2KE0">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-113"/>
    </dbReference>
    <dbReference type="PDB" id="2KO7">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-113"/>
    </dbReference>
    <dbReference type="PDB" id="2Y78">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="0.91 A"/>
        <property type="chains" value="A=1-113"/>
    </dbReference>
    <dbReference type="PDB" id="3UQA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.55 A"/>
        <property type="chains" value="A=2-113"/>
    </dbReference>
    <dbReference type="PDB" id="5V8T">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=2-113"/>
    </dbReference>
    <dbReference type="PDBsum" id="2KE0"/>
    <dbReference type="PDBsum" id="2KO7"/>
    <dbReference type="PDBsum" id="2Y78"/>
    <dbReference type="PDBsum" id="3UQA"/>
    <dbReference type="PDBsum" id="5V8T"/>
    <dbReference type="SMR" id="Q63J95"/>
    <dbReference type="STRING" id="272560.BPSS1823"/>
    <dbReference type="EnsemblBacteria" id="CAH39299">
        <property type="protein sequence ID" value="CAH39299"/>
        <property type="gene ID" value="BPSS1823"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1823"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5270"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVIAGWD"/>
    <dbReference type="EvolutionaryTrace" id="Q63J95"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="2KE0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="2KO7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="2Y78"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="3UQA"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="5V8T"/>
        </source>
    </evidence>
    <sequence length="113" mass="11930" checksum="10AB26FB56F3F284" modified="2004-10-25" version="1">MTVVTTESGLKYEDLTEGSGAEARAGQTVSVHYTGWLTDGQKFDSSKDRNDPFAFVLGGGMVIKGWDEGVQGMKVGGVRRLTIPPQLGYGARGAGGVIPPNATLVFEVELLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JC2</accession>
    <name>Q63JC2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TMP-TENI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552038.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111800.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63JC2"/>
    <dbReference type="STRING" id="272560.BPSS1796"/>
    <dbReference type="EnsemblBacteria" id="CAH39272">
        <property type="protein sequence ID" value="CAH39272"/>
        <property type="gene ID" value="BPSS1796"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1796"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6117"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMRGSDP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="196" mass="20351" checksum="7B9869A0244E300E" modified="2004-10-25" version="1">MHDDLALPPYYLITPEPASGSDADLTAFLDRLSDALATGLTLVQLRVKTLDAPAYAALAAGALARCRAQRARMIVNGPIAVEAALALGAAGVHLGSAALRAATARPLGSEGLLSAACHSLDELRHAQRIGADLATLSPVLPTLTHPGAPTLGWTRFAECAAHTRVPVYALGGMTRTHLETARAHHAHGIASIRGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JE6</accession>
    <name>Q63JE6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">DNA polymerase I</fullName>
            <ecNumber evidence="3 13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">polA</name>
        <name evidence="17" type="ordered locus">BPSS1770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3 13"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540200.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111776.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1770"/>
    <dbReference type="EnsemblBacteria" id="CAH39245">
        <property type="protein sequence ID" value="CAH39245"/>
        <property type="gene ID" value="BPSS1770"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1770"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5202"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 13 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="15">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="14">
        <location>
            <begin position="326"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="16">
        <location>
            <begin position="681"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAH39245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="923" mass="101289" checksum="E40A52FB9E47DAA5" modified="2004-10-25" version="1">MPEERNLEGKTLLLVDGSSYLYRAYHAMPDLRGPGGEPTGALYGIVNMLRRMRKDVSAEYSACVFDAKGKTFRDDLYADYKAHRPPMPPDLALQIEPIHTAVRALGWPLLMIEGVEADDVIGTLAKQAEQHGMNVIVSTGDKDLAQLVTDRVTLINTMTNEALDRDGVLAKFGVPPERIVDYLSLIGDTVDNVPGVEKCGPKTAVKWLTQYGSLDGVVEHAGEIKGVVGDNLRRALDFLPLARKLVTVETGCELAPHVESFDASLATDGEGRDALREIFAKYGFKTWLRELDSEPAAAAGAAAAGAAPDPASGATAELPLATARNYATVQTWEQFDAWLAKISAAELTAFDTETTSLDPMRAEIVGLSFSVEPGHAAYVPVAHRGPDMPAQLPRDEVLAKLTPWLEDAGKKKLGQHLKYDAQVLANYGIALNGIEHDTLLESYVLESHRTHDMDSLALRHLGVKTIKYEDVAGKGAQQIGFDEVPLAQASEYAAEDADITLQLHHALYPQIAREPGLTRVYRDIELPVSLVLRKMERTGVLIDGDRLSRQSGEIATRLVALEQEAYALAGGEFNLGSPKQIGQIFFERLQLPVVKKTPSGAPSTDEEVLQKLAEDYPLPKLLLEHRGLSKLKSTYTDKLPRMVNPDTGRVHTNYAQAVAVTGRLASNDPNLQNIPVRTAEGRRIREAFVAPPGSKIVSADYSQIELRIMAHISEDESLLRAFAHGEDIHRATAAEVFGVTPLEVTSDQRRIAKVINFGLIYGMSSFGLASNLGITRDAAKLYIDRYFLRYPGVARYMEETRMRAKEKGYVETVFGRRLWLPEINGGNGPRRQAAERAAINAPMQGTAADLIKLSMIAVDDWLERGGLRARMIMQVHDELVLEVPEDELSIVREKLPEMMCGVAKLKVPLVAEVGVGENWEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JG7</accession>
    <name>Q63JG7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12 16">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="6 12 16">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">gnd</name>
        <name evidence="18" type="ordered locus">BPSS1749</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 16">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12 16">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12 16">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="6 12 16"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190614.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111755.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1749"/>
    <dbReference type="EnsemblBacteria" id="CAH39224">
        <property type="protein sequence ID" value="CAH39224"/>
        <property type="gene ID" value="BPSS1749"/>
    </dbReference>
    <dbReference type="GeneID" id="56598103"/>
    <dbReference type="KEGG" id="bps:BPSS1749"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5176"/>
    <dbReference type="eggNOG" id="COG0362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:organic acid catabolic process"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
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        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
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        <property type="entry name" value="6PGdom_BS"/>
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    </dbReference>
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        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 12 16" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="17">
        <location>
            <begin position="180"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAH39224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="471" mass="50716" checksum="9A145248D6D3AF50" modified="2004-10-25" version="1">MGKQAIGVVGLAVMGRNLALNIESRGYAVSVYNRSREKTDELIAEFPDRKLVPAHTLEAFVASLETPRRILLMVKAGEATDATIAALKPLLDKGDVLIDGGNTHFTDTIRRNQELAQAGLHFIGTGVSGGEEGALRGPSIMPGGQRDAYDLVEPILEQIAAKAPADGEPCVAYMGPDGAGHYVKMVHNGIEYGDMQLIAESYAVLKQVAGLTNDELGAVYAEWNQGELDSYLIEITAKIFGKKDDETGEHLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKAQRVAASEVLSGPSPAPLEGDRAAFVESVRRALYLSKVISYAQGFAQLDTASKEYGWNLDLGTIAKIFRAGCIIRARFLQKITDAYAKNAALANLLLDPYFQDIAANYQSALRDVVIAAVKAGVPVPAFASAVAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHASWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JP7</accession>
    <name>Q63JP7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111675.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1670"/>
    <dbReference type="EnsemblBacteria" id="CAH39143">
        <property type="protein sequence ID" value="CAH39143"/>
        <property type="gene ID" value="BPSS1670"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1670"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5070"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RQGLHGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266925" evidence="2">
        <location>
            <begin position="28"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="63"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="33432" checksum="C1661BCAD4DA21B3" modified="2004-10-25" version="1">MTDRRTFVGGAAAFAAAWAAAPFGARAGIAVDLDPRQAGRVRAERDPAVVDATRRYRWVDDRAFTVAIAPHAPPVATFATDARTVVGADPDYAQLVADALGRRLALVPVAWADWPLGLSAGKYDAVISNVGVTEQRKRKFDFTTYRLGLHGFYVRAASPIARIAAPRDVAGLRIITASGTSQERILLEWDRRNVAQRLKPVDVLYFDDDAASRVALLSGRADAELNPNATLAYQAARDGRIRCVGNVNAGWPLKADVAIATRKGSGLADALTLATNGLIRNGKYRQALARWGLLSEALDRSETNPAGLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JR2</accession>
    <name>Q63JR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205657.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111660.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1654"/>
    <dbReference type="EnsemblBacteria" id="CAH39128">
        <property type="protein sequence ID" value="CAH39128"/>
        <property type="gene ID" value="BPSS1654"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1654"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5048"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EDEPAHM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="470"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="697"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="784" mass="86770" checksum="8FEB7F8D3B326B4D" modified="2004-10-25" version="1">MTTHSASTPPALPAAQCPFRPVSDDAAAHPARCPASAGAAAFDPFDDAYQQDPPEYVRWAREREPVFYSPKLGYWVVARYDDIKTIFRDNRTFSPSIALEKITPTGPDANAALASYGYAMGRTLVNEDEPTHMARRRLLIEPFTPDALRAHEPMVRRLAREYVDRFVDDGRADLVDQMLWEVPLTVALHFLGVPEADMDTLRAYSIAHTVNTWGRPRPDEQVAVAHAVGQFWQYAGKVLGKMREDPSGPGWMQFGIRMQREHPDIVTDSYLHSMMMAGIVAAHETTANATANALKLLLEHPRAWRELCDDPALIPNAVDECLRHSGSIVAWRRIATRDATVGGVAIPAGAKLLIVTSSANRDERRFADPDLFDIHRDNPADHLTFGYGSHQCMGKHLARMEMQIFIDELSRRLPHMRLAEQRFTYVPNTSFRGPEHLWVEWAPAENPQRRGHGARRCALAVRIGESNARRAGRALRVDSVMPVAERVLRVRLVAPDGAPLPRWSAGAHIDVECGDTGLSRQYSLCGDPAERGVYEIAVLREPASRGGSAWLHERLRPGMRVKIRGPRNHFRLDGHAARAILIAGGIGVTPIGAIAREARARGIDYALHYCGRSRRTMAFVDELAALHGERLRLHVSDEGTRHDFSALDVAAGTQVYACGPARMLDALAACAAHWPAHALRVEHFAAAAPRVDPRTDQPFEVELKDSGLTLTVPANRTLLATLRAANVDVQSDCEEGLCGSCEVRVLAGEVDHRDSVLSADERALNTRMMACCSRARRGRLVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW3</accession>
    <name>Q63JW3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative type IV pilus biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536546.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111609.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1601"/>
    <dbReference type="EnsemblBacteria" id="CAH39076">
        <property type="protein sequence ID" value="CAH39076"/>
        <property type="gene ID" value="BPSS1601"/>
    </dbReference>
    <dbReference type="GeneID" id="56597953"/>
    <dbReference type="KEGG" id="bps:BPSS1601"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5882"/>
    <dbReference type="eggNOG" id="COG3504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QGWQLAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018927">
        <property type="entry name" value="Pilus_synth_Q_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10671">
        <property type="entry name" value="TcpQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267276" evidence="2">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="TcpQ" evidence="3">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="189" mass="19155" checksum="6E2021F298665D17" modified="2004-10-25" version="1">MMHGATVAAAAFIAFALFATDCAASGPPAGTDPAPGGAFAERFDHAPLTAPRVDVVRAPQTAAPAGASRAADTVPAAQPPAGAAATAGQPPVADMPVADVPLRTLPAWDVRVSDGTIRGVLSRWANTAGWQLVWDAPVDFSIDAQATLRGSFEDALQALVASLGRTSTPIQAILYRGNHVLRVVAQGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K24</accession>
    <name>Q63K24_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface presentation of antigens protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bsaR</name>
        <name evidence="1" type="ordered locus">BPSS1542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187509.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111548.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1542"/>
    <dbReference type="EnsemblBacteria" id="CAH39015">
        <property type="protein sequence ID" value="CAH39015"/>
        <property type="gene ID" value="BPSS1542"/>
    </dbReference>
    <dbReference type="GeneID" id="56597887"/>
    <dbReference type="KEGG" id="bps:BPSS1542"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4897"/>
    <dbReference type="OMA" id="TIMEGCQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003065">
        <property type="entry name" value="Invas_SpaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03519">
        <property type="entry name" value="Invas_SpaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01305">
        <property type="entry name" value="SSPAKPROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="14838" checksum="A8F657E642BF28D5" modified="2004-10-25" version="1">MNVDVVMLVKESMEKMDCGNAIAGELDAHAPICIAFHSMPEMFVERDGEHVTIWSRLGCAGESQLARCAFDLLAYQLPRGSDAFASRRPLLSFVDDALVLHGRVEPRCLADAEGFTEALETFYADLCAVSEILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K28</accession>
    <name>Q63K28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Surface presentation of antigens protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bsaV</name>
        <name evidence="4" type="ordered locus">BPSS1538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530590.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111544.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1538"/>
    <dbReference type="EnsemblBacteria" id="CAH39011">
        <property type="protein sequence ID" value="CAH39011"/>
        <property type="gene ID" value="BPSS1538"/>
    </dbReference>
    <dbReference type="GeneID" id="56530053"/>
    <dbReference type="KEGG" id="bps:BPSS1538"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4893"/>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NNFAYAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003283">
        <property type="entry name" value="T3SS_OMP_SpaO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013385">
        <property type="entry name" value="T3SS_SpaO/YscQ/SpaO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01339">
        <property type="entry name" value="TYPE3OMOPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02551">
        <property type="entry name" value="SpaO_YscQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="FliMN_C" evidence="3">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="34746" checksum="CE817DEBDB37CA77" modified="2004-10-25" version="1">MSARYTLFRRVAPAELPLYRRARALRAAGEHAALRTIAPPRGYAALRATWRGVEHDGWVDLDDLMRRRYPALGALAWRALDRRYALDLLSGRDAAAELPAPPGGWAHVRLVDLVERALPAEPLLCFDTPGRARALFRAFPDEAPAARAVADIGGVPLTMRFAIGTARLPLALLPAVAPGDVLLVCAPRNVVRIGARALCEFCCEGENIMLNEPLADSAIDALHDASHDASHDEPTAAHAPPAFDIDALPVTLEFVLHDERVTVAQLAGCHPGMVLPLRGAPGEVTIRANGQPFGRGELIQVGEQLAVEVKALWRAKPAACDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KN6</accession>
    <name>Q63KN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC family leucine-responsive regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lrp</name>
        <name evidence="5" type="ordered locus">BPSS1325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184509.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111335.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1325"/>
    <dbReference type="EnsemblBacteria" id="CAH38796">
        <property type="protein sequence ID" value="CAH38796"/>
        <property type="gene ID" value="BPSS1325"/>
    </dbReference>
    <dbReference type="GeneID" id="56597528"/>
    <dbReference type="KEGG" id="bps:BPSS1325"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4622"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CLECHVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="169" mass="18533" checksum="ED21828EA7B32AA7" modified="2004-10-25" version="1">MRATKKSSPKAAAPPAGVDIDRVDRAILRVLQRDASVSNVALAAKVNLSPPACLRRVERLKEMGLIRGIVALLEPKALNAGMLVMIGVVLDRSTPDSFGAFEQAAQKVSGCMECHVVTGEFDYIMLIRTRDSDTFNRLHAEQLLYLPGVRQIRTFVVLKEILSTTSFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L08</accession>
    <name>Q63L08_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartate transcarbamylase</fullName>
            <ecNumber evidence="7">2.1.3.2</ecNumber>
            <ecNumber evidence="6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pyrB</name>
        <name evidence="14" type="ordered locus">BPSS1203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="7"/>
    <dbReference type="EC" id="2.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528489.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111213.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1203"/>
    <dbReference type="EnsemblBacteria" id="CAH38670">
        <property type="protein sequence ID" value="CAH38670"/>
        <property type="gene ID" value="BPSS1203"/>
    </dbReference>
    <dbReference type="GeneID" id="56530384"/>
    <dbReference type="KEGG" id="bps:BPSS1203"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4440"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDGPNEH"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="13">
        <location>
            <begin position="92"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="12">
        <location>
            <begin position="243"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH38670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="431" mass="47714" checksum="47AE8CB97E7CF805" modified="2004-10-25" version="1">MTVPQQAFLRDAMRRLNMTREAFANRIGVSRRALDTWLLPDDSQESRGMPEIVERFVSEIVERAPAADGYAQSVDSRQPLAQQFLFEGRPQLLSVDQFSRDSVEALFRVADVMQPIARRRKISRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVCDTTGFTFSSMAKGESIYDTSRVMAGYVDALVIRHPEQGSVAEFARATNLPVINGGDGPGEHPSQALLDLYTIQREFSRLGKIVDGACIALVGDLKYGRTVHSLVKLLALYRGLKFTLVSPPTLEMPAYIVDQISKNGHVVEETHDLAAGLKGADVVYATRIQKERFTDESFEGYTPDFQINQARVDAACGPDTLIMHPLPRDSRPGANDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLLGVEHLVQHSMRDATWRPPTYLGPEDAVFHGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LB1</accession>
    <name>Q63LB1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative capsule biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004557566.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111110.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1097"/>
    <dbReference type="EnsemblBacteria" id="CAH38565">
        <property type="protein sequence ID" value="CAH38565"/>
        <property type="gene ID" value="BPSS1097"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1097"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4302"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYGCGDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="14"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="377" mass="41535" checksum="19640BE373E31C07" modified="2004-10-25" version="1">MNETDDAPLHARVRLFLCGDVMTGRGIDQILPHPGAPRLYERYCRSARDYVRLAERANGELPARVDCAYPWGDALAELDRVRPHVRIVNLETAITTSDARWPDKAVLYRMHPRNVGCVSSARIDCCVLANNHSLDWGREGLADTLDTLRRAGIRTAGAGDDDAHAARPATLGVAPGRRVLVYAYAAETSGVPPSWAATPRRGGLNYLADLSSGRATQIGERIAAQRREGDLVVVSLHWGGNWGFEIGDDEHAFAHRLIDTGAADIVYGHSSHHVKGIEIYRERLILYGCGDCLNDYEGIHGHQPFRPDLALMYFPVLDAGSGALVELSAVPMQIRNLRLQRAPADGKAWLHAVLERESRRFGTHVSACDVDGLHVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LC7</accession>
    <name>Q63LC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage protein gp17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205531.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111094.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1082"/>
    <dbReference type="EnsemblBacteria" id="CAH38549">
        <property type="protein sequence ID" value="CAH38549"/>
        <property type="gene ID" value="BPSS1082"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1082"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4280"/>
    <dbReference type="eggNOG" id="COG4675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPAINAP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="787" mass="83142" checksum="3E35AAB7BA783061" modified="2004-10-25" version="1">MVIHITDAGRAALVAGGNTGTAARRVVEIGLGTAPFAFDRGMKTLPNERKRVTTFGGENVAPDTVHVVIQDDTNDQYSLYAFGLYLENGVLFAVYVQDAPILEKSPAAMMLLATDVVFATIDAAKLEFGPATFLNPPATTERKGVVELATQAEVDAGDDDTRAITPKTAKRRYAALSGATFDGRVRVVADVDDRAAQLDVSPKTAGVGKAGKARLFGTFGDATLPDLSPRLVATLRAGFDAGAWGREYVDVCLNDGTNNDAASDAKQKRVARFASGGRVLIGERADDGKTALQVRGGVDASEGVAARAIDAGGAGGQFRAVYDGYGAFIRNDGRSVYFLSTPKGAPDGGFNDYRPFSWSLSTGQVIVDGSGAGTVFGGAVDVARDLEVGRQASEGHIKLGPVDGYLYANPVSTGWWSPAGSSYQYIFADHTFRIDGRMAWHEGNLDPLDKSKGGMLAGDVSFAPGKRLVLAEGSPAAPSLTFGNDGAPDTGLYHAADGEFGVACNARAVVRFSSSLVAFEHPVTVPTPPAADRSTRAATTEWVRTVLSATTIGQIVFEPRTTVRPGFLKANGVLVNRADYPELWAYAQASGALVSDADWMKDRWGCFSTGDGATTFRLPELRGEFIRCWSDARGGVDATRQIGAFQGDQNHTHAHGAAASEAPDHVHTAWTDVQGWHGHHGWTNAVGDHQHVSPWGEHPQMYNPPWGTWGAANNRGAEGSDNDNVYGMTSPAGNHNHEFNTEGNGNHGHAVGIGGGGRHAHTIAVQPDGGDEARPRNVALLALIRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LJ3</accession>
    <name>Q63LJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199294.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111028.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1022"/>
    <dbReference type="EnsemblBacteria" id="CAH38483">
        <property type="protein sequence ID" value="CAH38483"/>
        <property type="gene ID" value="BPSS1022"/>
    </dbReference>
    <dbReference type="GeneID" id="56597394"/>
    <dbReference type="KEGG" id="bps:BPSS1022"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4205"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHLTRYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="173" mass="19931" checksum="BF781BB5781BD08C" modified="2004-10-25" version="1">MSFESDVVGWLPQLRRYARALTGDPAWADDLVQDTVERAFSRMRAFRPDSNLRAWLLTILRHLYIDQLRARREFAVDDDEGPWRTLEAPAGQIDALVLRDVQRMLYRLPLEQREVLLLVCVEELSYQDASAVLGVPVGTVMSRLSRARERMRALLTDAPLRPPLSLTAARHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LR7</accession>
    <name>Q63LR7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subfamily M23B unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205486.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110954.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0945"/>
    <dbReference type="EnsemblBacteria" id="CAH38408">
        <property type="protein sequence ID" value="CAH38408"/>
        <property type="gene ID" value="BPSS0945"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0945"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7255"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANGYKGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="32028" checksum="1D5F4F60362E5E08" modified="2004-10-25" version="1">MSKSEIDRSVAWLSGVAAAFVVAGCATTSPVTPTDTLAAAASSASAAQPAAAPPGDAAQHPEHAAAPAPIATRYVVRRGDTLSAIAQANGCTVRELQAWNRMGRRTRIGIGQVLRIAPPGAENAVASEAADGVGATRAAGNAAGAARAADPASGAGGAPVADAPQPASAPESAADRAADHRVVQETKRHAQSIALAWPAKGAVVETFQPGRNRGIRIVGRAGDPVRAAASGRVMYAGTGLNGYGTLILVQHNADFLTAYAHNRKVLVKTGDVVQQGEQIAEMGTGDSTRAGMLFEVRRDGKPVNPMPYLASRQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LS2</accession>
    <name>Q63LS2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase/Mu-crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551610.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110949.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0940"/>
    <dbReference type="EnsemblBacteria" id="CAH38403">
        <property type="protein sequence ID" value="CAH38403"/>
        <property type="gene ID" value="BPSS0940"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0940"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7246"/>
    <dbReference type="eggNOG" id="COG2423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QARWQTR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="317" mass="32150" checksum="44AA3B83A040D11F" modified="2004-10-25" version="1">MTTPVFDAAQTARVTPFAELVDALRTAALDADAGCIESPARLVVPLNEGGVMLSMPASAADLAIHKLVTVCPRNRGGDLPTIQGQVSVVDPATGAPLFALDGPTVTGRRTAAVTLLALRTFVAAAPRDVLLIGTGTQAAHHVEALAALFPGVRVRVKARAPAQAAAFCARLRAVLPTLEPLGGDTLPETLDAVITATTSATPVYDDAARAGRLVVGVGAFTPGAAEVGARTIAGSALYVDDPAGARHEAGDLIVAGVDWARVRSLADALRATVSTPASNASPAPGAPVFFKSVGCAAWDLAACRVARAVTSRTRACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LV0</accession>
    <name>Q63LV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195428.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110921.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38374">
        <property type="protein sequence ID" value="CAH38374"/>
        <property type="gene ID" value="BPSS0912"/>
    </dbReference>
    <dbReference type="GeneID" id="56597272"/>
    <dbReference type="KEGG" id="bps:BPSS0912"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7208"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GEISQVN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17909" checksum="97F3E57C8D8D16CE" modified="2004-10-25" version="1">MKLDETDLKILKILQENGRLSNAELADRVALSAAPCWKRLRRLEADGFISGYQAILDRRALGYEIVAFVNISLDSHTEKTCRAFEAGVMAMPEVVACHNTTGQHDYLVQIVAKNFDTFSSFVLNRLRSLPGVKELLSTISMRELKATSRLPAGELRITKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LX3</accession>
    <name>Q63LX3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551577.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110898.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0889"/>
    <dbReference type="EnsemblBacteria" id="CAH38351">
        <property type="protein sequence ID" value="CAH38351"/>
        <property type="gene ID" value="BPSS0889"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0889"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7182"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQFGIEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="158"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="401" mass="42930" checksum="734B5421AE34CF39" modified="2004-10-25" version="1">MRRVSSFLLRLTIIGVLLHVYIGFRLLPELASPAARYAGALWLVGSCLLIPLGMLSRVFERQPLGDRVAWAGLLAMGFFSSLLVLTLARDVLLASLVTVDALAPGAVSLAQWRIQTAAGVPLAALAVSVVGFVNARRRARVVDVAVPIDDLPAALDGFTIVQISDIHVGPTIKRGYVEAIVDAVNRLAPDLVAVTGDVVDGTVAQLAGHAAPLGRLRARHGAFVVTGNHEYYSGADEWIAEFRRLGLDVLLNEHRTLDHGDGRLVIAGVTDYSAGHFDPAHRSDPSAALAGAPADVRIRVLLAHQPRSATAAADAGFTLQLSGHTHGGQFFPWNFFVRLQQPFTAGLARLDGLWVYTSRGTGYWGPPKRLGAPSEITRVRLVRGEGNRTRAPASVTLNAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M05</accession>
    <name>Q63M05_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523965.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110866.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0854"/>
    <dbReference type="EnsemblBacteria" id="CAH38317">
        <property type="protein sequence ID" value="CAH38317"/>
        <property type="gene ID" value="BPSS0854"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0854"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7141"/>
    <dbReference type="OMA" id="SDNSIGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266428" evidence="2">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="16899" checksum="CD296EE7EE86602D" modified="2004-10-25" version="1">MKTFSHALKRVVALVIAMPAAAGWASGQHRHGAADADELPRAFAAKEMGRSAAGARSYGSPVTSVFEEAKGALPAFDAKRSGAAGAAGFAHELGAAERRQRLAEEDRAVQRLRDSRHDGRGRWPGGAMPPRVPGRPDIAIEKPVPGVTCASGSDNSIGCGTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M72</accession>
    <name>Q63M72_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolase C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200876.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110799.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0790"/>
    <dbReference type="EnsemblBacteria" id="CAH38250">
        <property type="protein sequence ID" value="CAH38250"/>
        <property type="gene ID" value="BPSS0790"/>
    </dbReference>
    <dbReference type="GeneID" id="56530758"/>
    <dbReference type="KEGG" id="bps:BPSS0790"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7042"/>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVHEHNV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="3">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="440" mass="45775" checksum="519C970235577BB1" modified="2004-10-25" version="1">MSMTVSTPASPELSADGVRRVLLAGYARSDGRKGIRNVVAVAYLVECAHHVAREIVAQFRAPPRLGDAAPAAEAPPVHLIGFPGCYPNGYAEKMIERLATHPNVGAVLFVSLGCESMNKHYLVDAVRASGRPAEVLTIQEAGGTLNTIGAGVDWVRDARATLARQAKVPMGVGELIVGTICGGSDGTSGITANPAVGRAFDLLVEQGAACLFEETGELVGCEYHMQSRAARPELGREIVACVKKAERYYSILGHGSFAVGNADGGLTTQEEKSLGAYAKSGASPIVGIVKPGDVPPTPGLYLLDVVPDGEPRFGFPNISDNAEIAELIACGAHVILFTTGRGSVVGSALAPVVKVCANPATYRKLEGDMDVDAGRILEGRATLDEVGREIFAKTLAVASGAASKSEALGHQEFILTYKAFEPLGPACLPVAGPLRAVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MB6</accession>
    <name>Q63MB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551506.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110755.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0743"/>
    <dbReference type="EnsemblBacteria" id="CAH38203">
        <property type="protein sequence ID" value="CAH38203"/>
        <property type="gene ID" value="BPSS0743"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0743"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6978"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPLAIVC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="25"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="505" mass="53829" checksum="52DFE2B2CF4EC263" modified="2004-10-25" version="1">MKHDSNVTSPLGHLIDGKRVDGGERVQPVFDPATGASTKRVRMADRPSVEAAIAAAQAAYPAWRNTPPLKRARVMSRFKTLLEEHANELCALITAEHGKVLADAMGELQRGIENVEYASYAPELLKGEHSKNVGPAIDSWSEFQALGVVAGITPFNFPIMVPLWMWPMAVACGNTFVLKPSERTPSSTLRMAELALEAGLPPGVLNVVNGDKEAVDTILTDSRVKAVSFVGSTPIAESIYTTGCAHGKRVQALGGAKNFAIVMPDADIGNAVNALMGAAYGSCGERCMAIPLVVAIGDDTAEQVVDGLKAEIAKMKVGPGTGEQVDMGPLVTRQHFEKVTGFVEAGIAAGATLVVDGRGVKVDGHEGGYYLGPCLFDHVKPGMPIYQHEIFGPVLGVVRVASLAEAMALVDAHEYGNGTCLFTRDGEAARFFSDNIQVGMVGINVPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTITQRWPSAGVREGTVFSFPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ME0</accession>
    <name>Q63ME0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551493.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110731.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0717"/>
    <dbReference type="EnsemblBacteria" id="CAH38177">
        <property type="protein sequence ID" value="CAH38177"/>
        <property type="gene ID" value="BPSS0717"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0717"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6938"/>
    <dbReference type="eggNOG" id="COG3447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFRTHIS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="MASE1" evidence="7">
        <location>
            <begin position="14"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PAS_3" evidence="8">
        <location>
            <begin position="332"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="45757" checksum="8BC8A7C00BA88796" modified="2004-10-25" version="1">MNTKRSRPELVAALLWAALYLASGYLSHALNGPVRLTGYIWLPAGVTVGAFMLRPVREWPMLAAAFVAAQLALTGIEHGNPFNAALFAIDELGAAALAVGFVRRIRFSLEGLYFLRSVILAGVIASVLGALGGAAWYTVVNGASFVDVGLVWAASDFIGVLLVTPVLASWSRFRAHRSGDHERFDLMLGIAAFALVAIGAFAIFDGDSASKFGIGAGFAMTYIPLFLTVAVTLLLGGRAGSSSVLVLALIVIMQTAQGEGPFASLDANHGRSLLEAQLYLAVASLLVLTVSTLKTTRERVHEHAQVLRNNMELALASAGQIAYVLDPSSGRIDWSGDVERVFGVGVDAAQIASVPLVLERVHADDRDALRDYWRAEIAGEDRASLSLRVVQRDGGTQTITDHGAPLLDSNVDVAVVAGVWQIERVWPADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MI9</accession>
    <name>Q63MI9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1653 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194631.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110682.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38127">
        <property type="protein sequence ID" value="CAH38127"/>
        <property type="gene ID" value="BPSS0668"/>
    </dbReference>
    <dbReference type="GeneID" id="56597651"/>
    <dbReference type="KEGG" id="bps:BPSS0668"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6873"/>
    <dbReference type="eggNOG" id="COG4728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIYRHYK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="1">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="72" mass="8572" checksum="1FC3F31BFDB8606C" modified="2004-10-25" version="1">MTEQEAERIATHRHYKGGLYRVIGVARHSETEERLVVYEQLWPKERSLWVRPEAMFEETLADGTPRFRKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS6</accession>
    <name>Q63MS6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535091.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110593.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0572"/>
    <dbReference type="EnsemblBacteria" id="CAH38029">
        <property type="protein sequence ID" value="CAH38029"/>
        <property type="gene ID" value="BPSS0572"/>
    </dbReference>
    <dbReference type="GeneID" id="56530978"/>
    <dbReference type="KEGG" id="bps:BPSS0572"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6741"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APHIRRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="329" mass="35675" checksum="035B1B1081F3E806" modified="2004-10-25" version="1">MHAWSAQHVPPQGGKVAVVTGANSGLGWQIAQTLAAKGAQVVMGCRDTAKGELAAHAIRTRYPRARIEVEALDLADLASVCRFADAVADRHGRVDILCNNAGVMFLPLRHTRDGFEMQMGTNHLGHFALTGLLLPALRASHRARVVTMSSGFNRLGKIRLDNMLAERGYNKYRAYCDSKLANLMFTLELQRRFDQACLPILSVAAHPGYAATHLQFAGPEMANSSLGTFAMRLSNRLVAQSADVGALPAIHAATAVDVDGGAYIGPAHLCETRGYPAEARIPRQARDVRMGKRLWEKSEQLTGVRYLDTPPPPGSRRRASRDDATFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MU0</accession>
    <name>Q63MU0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purU</name>
        <name evidence="5" type="ordered locus">BPSS0558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186920.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110579.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63MU0"/>
    <dbReference type="STRING" id="272560.BPSS0558"/>
    <dbReference type="EnsemblBacteria" id="CAH38015">
        <property type="protein sequence ID" value="CAH38015"/>
        <property type="gene ID" value="BPSS0558"/>
    </dbReference>
    <dbReference type="GeneID" id="56530992"/>
    <dbReference type="KEGG" id="bps:BPSS0558"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6726"/>
    <dbReference type="eggNOG" id="COG0788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTIFHLP"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="96"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="291" mass="32794" checksum="F7C6CDF0D491147F" modified="2004-10-25" version="1">MSVPQRPHQFVLTLSCPSAAGQVAAVVGLLDRHRCYVDELTVFDDDLSARFFVRCVFHATDDADALRVDALRREFEPIAERFRMQWAIHDVAARPKVLIMVSKLEHCLADLLFRWKMGELKMDIVGIVSNHPDFAPLAAQHGLPFRHFPITADTKAQQEAQWLDVFETSGAELVILARYMQVLSPEASARLANRAINIHHSFLPGFKGAKPYHQAHARGVKLIGATAHFVTDDLDEGPIIEQVVERVDHSYRPEQLLAVGRDVECITLARAVKAFIERRVFLNGDRTVVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MW0</accession>
    <name>Q63MW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524286.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110559.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0538"/>
    <dbReference type="EnsemblBacteria" id="CAH37995">
        <property type="protein sequence ID" value="CAH37995"/>
        <property type="gene ID" value="BPSS0538"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0538"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6702"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGWISTS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="34"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="528" mass="56188" checksum="497F91158062D65F" modified="2004-10-25" version="1">MSAPARPAAAAANGAGAHEPAAARPLRGAKLALLTFALSLATFIEVLDSTVANVAVPAISGSLGVSNSQGTWVISSYSVAAAIAVPLTGWLARRVGEQRLFVASVILFTLTSLLCGLARDLEVLVACRALQGLFSGPMVPLSQTILMRAFPPAKRTLALALWGMTVLLAPIFGPVVGGWLIDNFSWPWIFLINLPIGLFSFAVCTLMLRPRASRGEASPIDVPGIVLLVIGVGSLQAMLDLGHDRGWFDSSLITALAIAAGVSLVSLLIWELGEAHPVVELSLFRERTFTFCVVIISLGMMSFSVVGVVFPLWLQAVMGYTAYQAGLATASMGLLALVFSILVGVYASRVDARVLVTFGFGVFAAVMGWSTHFTLSMTFAQVVTPRLIQGMGLPCFFIPLTAATLSRVADDKLAAASSLSNFLRTLSAAFGTALSVTWWDNRATYHYAVVSQAVTRASENTQRYVDALHAMGLHGARELSSLHQVVRQQAYMMATNDMFYMASVTCVLLAGLMWLTRPKRGAAATMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MX5</accession>
    <name>Q63MX5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535244.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110544.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0523"/>
    <dbReference type="EnsemblBacteria" id="CAH37980">
        <property type="protein sequence ID" value="CAH37980"/>
        <property type="gene ID" value="BPSS0523"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0523"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6683"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VWTHRYE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="3">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="763" mass="82708" checksum="04CA8FC7B298DD3F" modified="2004-10-25" version="1">MRLIELRSPLLDPDAVALSFVVHENLSQEPSYQLDLLSHDPDLDFDALLGSTLSADIDLGEGDIRTFNTHVFGGYDTGQMSGQYTYTLELRSWLSFLAENRNSRIFQNMSVPQIVEQVFQGHQRNGYRFELEGTYEPREYCVQFQETDLNFVKRLLEDEGIYFWVEHEPDRHVVVISDTQRFEDLPLPNDTLEYLPDGEESRAIQGREGVQRLQRTRRIKSNNVALRDFDYHAPSNKLDSDAQQVSPPNLEGIPLEYYDYAAGYREPEQGERLARLRLEAIQAESHTLVGEANARALATGRAFTLIGHPALGRNRRYYVTNSELTFIQDGPDSTSQGRNVAVKFRALADDQPFRPLLTTPRPEVPGIQSATVVGPEMSEVHTDKLGRIRVHFHWDRYKTTEADASCWIRVSQAWAGKGWGVIAMPRVGQEVLVTYVDGDLDRPLVTGIVYNGENPTPYDLPKDIRYTGLVSRSIKRAGGYQNASQITFDDQRGAERVMIHAERDMQQTVERNSSTSIAQDLNLSVKGTSTSVVGISISFTGISVSYTGLSVSFTGVSASFTGLSTSFTGVSTSFTGVSTSFTGVDTSFKGVSTSFTGVDTSFKGVSTSFTGVSTSLTGSSNSVTGVSNSMTGISSSWTDVSMSTTGQSQSITGVSLSYTGTSNSMTGTSTSVTGTSTSITGTSMSNTGSSTSITGTSMSTTGSSTSVTGSSVSTTGSSVSTTGSSVSTTGSSVSTTGFSFSYTGVSYSDTGIDLKKVGMQVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MZ1</accession>
    <name>Q63MZ1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-aminoethylphosphonate--pyruvate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-aminoethylphosphonate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">AEP transaminase</fullName>
            <shortName evidence="4">AEPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnW</name>
        <name evidence="7" type="ordered locus">BPSS0507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in phosphonate degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:17021"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57418"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58383"/>
            <dbReference type="EC" id="2.6.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.37" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525538.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110528.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0507"/>
    <dbReference type="EnsemblBacteria" id="CAH37964">
        <property type="protein sequence ID" value="CAH37964"/>
        <property type="gene ID" value="BPSS0507"/>
    </dbReference>
    <dbReference type="GeneID" id="56531044"/>
    <dbReference type="KEGG" id="bps:BPSS0507"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6665"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRINHMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047304">
        <property type="term" value="F:2-aminoethylphosphonate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01376">
        <property type="entry name" value="PhnW_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012703">
        <property type="entry name" value="NH2EtPonate_pyrv_transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03301">
        <property type="entry name" value="PhnW-AepZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3 4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4 5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="38281" checksum="4B53B331D77BB0E0" modified="2004-10-25" version="1">MLLLNPGPVTLTERVRQSLLQPDLCHRESEFFDLQDEARARLVAAYALDPAEWSAVLMTGSGTAAVESMIAALVPENGKLLVIENGVYGERITQIATQYRIAHDVLKHDWMQAPDLARVAEKLDADRAITHVAVIHHETTTGRLNDLDALAAVCRARGVRMLVDGVSSFGAEAIDFAGGDIDALAATANKCLHGVPGAAFVIVRRRALASAASRTYYLDLGRLAKLQDARNTPFTPSVHAYYALVEALREFDEAGGWRARHARYAALAEQVRAGLAARGMPLVLPDGESSVVLRAYRLPAGVAYEQLHDGLKARGFVIYAGQGGLSSALFRVSTMGAIEPADVERLLDGFTALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N08</accession>
    <name>Q63N08_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110511.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37946">
        <property type="protein sequence ID" value="CAH37946"/>
        <property type="gene ID" value="BPSS0489"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0489"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4497"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRWELEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266175" evidence="2">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16234" checksum="CD2D6CAFBA8C72E2" modified="2004-10-25" version="1">MRRDTAFRLVKASPSAVYAAFVASEAVAQWLPPEGAMMEIQVFEPRVGGRFQMTLIFASAPGKSTANTDVVVGRFVELVPQQRIVQAFEFDSPDPVFAGAMTMRWELEAAAGGTAVTVVAENVPPGISQTDHETGMNSSLTQLAAYVESHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N11</accession>
    <name>Q63N11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS0486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530004.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110508.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0486"/>
    <dbReference type="EnsemblBacteria" id="CAH37942">
        <property type="protein sequence ID" value="CAH37942"/>
        <property type="gene ID" value="BPSS0486"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0486"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6638"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAPERFI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1192"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1291" mass="138450" checksum="D5EEAEA8B6027776" modified="2004-10-25" version="1">MTTTNLPKTINELLRVRAATRGEKVAYLFLSGQPDDEQRQSITFAELDRTARRVALLLQRQSVGVGERVLLLCRPGLDYIAGFLGCLYAGAVAVPAYPPRNRQHASRVVGIVESAGAKAILSTGDDFARCTKLLEDTAASHVALLDLDAAKPLDATLEPADVAPSHVAFLQYTSGTTGKPKGVMVTHGNLIHNLALIGQWMGYHEESTMVSWLPPYHDMGLIGGILTSLFGGFRCVLMAPERFIQHPFLWLRAISDYRADVTGAPDFAYRMCSRRVPDEQLATLDLSCLKTAYSGAESVRYGTLAEFAQRFARTGFDSERFKPCYGLAECTLLVAGRSAPRPLRTVCVDQAALQQQKVVIRRAFEGLAPQLDERDGERVLVSVGVTIGEQRVVVRDLNTNERCADGEIGEICVAGPSVAPGYWQQYEQTLATFQRGIGGETGQAFAGTGDLGFHHRGDLYVTGRLKDMIIIAGRNYYSEDIEYAVIGSRPELVPNGCAAFTVDAGDEERLVVVAEIERTHRKGDLDALLKGIREAIWLRHDLSPGAVLLVSPGSVPKTSSGKVRRGECRKRLGDGELTVLARWDADDCIAAATRGDTAANAPSNVPSSAPASAAATAPAAPAEKTPAADAAGAASPNAAKVEQLKDWLRHYARTRIDSRTIDERRTIPPHIVLDFGNEGLLGMQIDRAYGGLGLTNREMLQVVSQLATIDSTLAFFVGLNNTLGIRPIMLHAQPALRDELLPLLATGRTLAAFALTEPDAGSNARAIASVAQRADGGHWVVSGRKSWSGSSAWAGVINVFAKQADGAGMVGLALRQGTPGLRIGAEDLTMGVRGMIQNTLHLERARVSDACRLGAPGQGMAVAQQTMNFARLGIGAVCVGAMKRCAQLMHRYAARRRIGTGLLLDHPLSRQRLGDLRHRIDALSALIEQLAADFDAGRDAPEDGLLIAKILGSECLSQTSDELMQMLGGRGYIETNVAPQLFRDARLPRIFEGPTETLLAHLGSRLLNGGDDLLGYLGERSGALALAAELRGLGEQLLEDGLANADALGGAAHAANWVNYWLGSVAQWALLLAVVEQAAKRRGVDGATLEWAQSQYELALEAAQRQVGRRRVLASAAQLGEWAQRVEREIGPIEQTVPGATQRVDPLLRAECDVRSQPSDIGALDDDEPPAAGVPPAPVPSPASASAEQADPELKREVERWLLTWLGARLRNRRIALTAETTFADIGLDSILAVELTMAFGDAFRTTVDASAVWDHASIDALATHLAARMDRHAPAQADAASSAPSASSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N69</accession>
    <name>Q63N69_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative heptosyltransferase (O-antigen related)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110450.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0426"/>
    <dbReference type="EnsemblBacteria" id="CAH37882">
        <property type="protein sequence ID" value="CAH37882"/>
        <property type="gene ID" value="BPSS0426"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0426"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4419"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYYCISE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="38798" checksum="C8F07FDD3E6EB940" modified="2004-10-25" version="1">MLIIKLSAMGDSLCLFPTVRQLALAFPGATIDWLTSNRSNPALFAELPFIRTIFVTPPSLVRALTYLGGWLFRARRYDLTIDYDQYYCISELIAGMSACSAGFRTSLKGTTFSLSVEYDPLLNEKAMFRKLTERVFATYGVSIPDYRAELPELIERFVPSAQLQTLRARLKAQGKPIVGIYPGSGANATFRRWGVGNYVALIERYKDRYAFVLLGGPDERDLQADLKDIDGVFNLIDSMSFKEVAWFLKHTIDLLVGNDGGLLHVAESQAVATVGIFGPALYRKWGSSLERSIGVEKELPCRPCLKNYLGTVPSACCLGTTACLSAISTDDVAQAMHRAVHRIHVVPIAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NR6</accession>
    <name>Q63NR6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytochrome oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541442.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110253.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0234"/>
    <dbReference type="EnsemblBacteria" id="CAH37680">
        <property type="protein sequence ID" value="CAH37680"/>
        <property type="gene ID" value="BPSS0234"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0234"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6317"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFPDTAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="37062" checksum="E71BC6E2B0F5D6BC" modified="2004-10-25" version="1">MDVTVIWAAIIALGLFMYVVLDGFDLGIGIVFPFFPAEQERDLMMNTVAPVWDGNETWLVLGGAGLFAVFPIVYSTVLSALYLPLVFMLVCLIFRGVSFEIRAKARRTKHLWDLAFIGGSTGATFFQGVALGAFLQGIPVDGGRFAGDAFGWLTPFSLLTGLGLIATYALLGCCWLVAKTEGDLQRRLHRVVWPLTVVLLGFIAVVSLWTPLQDTNIAQRWFATGLFWRLLPVPFLVAGCAALMRRAVRERHDTTPFALALALVFLGYVGLLASLWPYAIPQSVTLWEAAAPRSSQTFTLIGAAVIIPVILAYTTMGYWVFRGKVRHEDQHYYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P15</accession>
    <name>Q63P15_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538885.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110154.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0133"/>
    <dbReference type="EnsemblBacteria" id="CAH37578">
        <property type="protein sequence ID" value="CAH37578"/>
        <property type="gene ID" value="BPSS0133"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0133"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6175"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTEPWTW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="114"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="36810" checksum="F4C4802E273F740A" modified="2004-10-25" version="1">MTEVDAGQTPHAAILQMVTGKWHAQALYVAAELGIADLLAQRERTADELAAETQTHPEALYRVLRALGSLGVFVEEDGRRFRNSPLGDTLRRDAPGSMRGFVRFAGMDAGWRAWGQLMYSVRTGRSAFEHVVGGPGFAYIDSHPEIAAIVNDAMTSMSELEAPAVARAYDFSQARTIVDVGGGHGFLLATLLRANPHANGVLFELPHACEGARQLFAKHRLTERVKVIAGDASQSIDAHGDVFVMKHVICDWDDEQATRIMTNCAEAMRPGGKLLLVEAVLTPPGEPHFAKLHDLEMLIMSSGGHGRTADGYGRLYAAAGLTMTAVRPTQGMNSVIEGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P37</accession>
    <name>Q63P37_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205343.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110132.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0111"/>
    <dbReference type="EnsemblBacteria" id="CAH37556">
        <property type="protein sequence ID" value="CAH37556"/>
        <property type="gene ID" value="BPSS0111"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0111"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6140"/>
    <dbReference type="eggNOG" id="COG3520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVFEPEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03347">
        <property type="entry name" value="VI_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="349" mass="38939" checksum="754B60B43AB2E7B0" modified="2004-10-25" version="1">MTAHPPAARPIDAHSPLHPDALRAWFDPQAPWRAGFLSLLRAIAARDTRVPLPGTACLPKEEAFRIGQRPSMAFAPREIASLDVQRGRLDIQLFGLGLWGPQGPLPLHMTELAYNRAESYQDHAIAHFSNLFHHRALALFYRAWASSQATVSLDRAEHETFSFYIGSLMGTDPEEAARTHPPTHARYAACAHLVREARNPDGVAATLSHYFGVPIAVDEYVFHWIRIAPPERCLLGARAASTVMGEGALLGDMVADCQHKFRLVIGPLDLDQYLRLTPHGNDLPTLVDWVRAFVGHEYDWEIKLLVKPRAAPPARADTTHRLGYSTWLGESRDDRPVVGMVFEPEKYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PD4</accession>
    <name>Q63PD4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="5">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-malate + NAD(+) = CO2 + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205320.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110035.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0011"/>
    <dbReference type="EnsemblBacteria" id="CAH37454">
        <property type="protein sequence ID" value="CAH37454"/>
        <property type="gene ID" value="BPSS0011"/>
    </dbReference>
    <dbReference type="GeneID" id="56531544"/>
    <dbReference type="KEGG" id="bps:BPSS0011"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6006"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KLFRQPS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="6">
        <location>
            <begin position="7"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="361" mass="39698" checksum="E472D1217C7BC9A8" modified="2004-10-25" version="1">MSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRAKRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PE5</accession>
    <name>Q63PE5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530472.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110024.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63PE5"/>
    <dbReference type="STRING" id="272560.BPSL3431"/>
    <dbReference type="EnsemblBacteria" id="CAH37443">
        <property type="protein sequence ID" value="CAH37443"/>
        <property type="gene ID" value="BPSL3431"/>
    </dbReference>
    <dbReference type="GeneID" id="56527722"/>
    <dbReference type="KEGG" id="bps:BPSL3431"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3902"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQRKGPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="213" mass="23392" checksum="1950A8CD06D905B1" modified="2004-10-25" version="1">MSDGVYGNQAAGRVTHSLLRLSTAMRSQAWDWAEGAGLTPTQGEILVLLLQRKGPMRLGEIARETQLTAATTSDAVSTLEHKGLVEKRRALDDGRALAVRLSARGRTAAKKALQWPDFLSKAVGTLGGDEQGVLYRALLKTLRELQVNGDIPPHRMCVTCKHFQPGKAARKPTYRCSLLDLTMTDSDLRLDCAVHEEADVLTQKKTWKLFAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PK9</accession>
    <name>Q63PK9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL3365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109960.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3365"/>
    <dbReference type="EnsemblBacteria" id="CAH37378">
        <property type="protein sequence ID" value="CAH37378"/>
        <property type="gene ID" value="BPSL3365"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3365"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3824"/>
    <dbReference type="eggNOG" id="ENOG503152P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DINHPAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="393" mass="43299" checksum="7C2FB0782B068B33" modified="2004-10-25" version="1">MTKKRAYTSKTGNQTVTAQAVLKERNRFYGGAPTGKSYYSMHPAGERKDVVHVRKGSGYFAYKRGDAGHGGAAEGESLNHILFKEALCSVSHTKLVLYRQTPGAPALWRRKVPITVQAARAEEPVPRRDGPPYRADVYLEFATDDDLGLKWQRRVYIEIRHAHAVDARKQDELRTLGIPVVEVDINYPAYMYPFSDDETTDEREDAHRKRLKHMLEHENGFLQGVVLSNPSSNEYLQKLVGEQRRKLDSQQAELDRLAAGIAERDGRLAAAAEAKLQSDQRCRDARAALERVSEQLSAVSDERTRALRKQQALAEQLARVRAGRRVAYGGCAALVALAAVLGYAHWQRPPALSAARPAPLAQAPAAAAGGAQRATGRAAASPKHRSRPRANGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PN4</accession>
    <name>Q63PN4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525720.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109935.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3339"/>
    <dbReference type="EnsemblBacteria" id="CAH37352">
        <property type="protein sequence ID" value="CAH37352"/>
        <property type="gene ID" value="BPSL3339"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3339"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1868"/>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDLWWAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="553" mass="60134" checksum="982AB8005F63835B" modified="2004-10-25" version="1">MSYVYVDGADPRHSTLQKGFNLRWPPTAEAGAAAIYVCRTADDVIAASRDALAKGCRITVRSGGHCYEGFVANRLPDDHGRPLAIIDLGLMSGFDIDDRGQIASPFDAAGAPRYRVRVAAGRQNWDGYVGLYKTMGKTLPGGSCYSVGAGGHIVGGGYGLLSRLHGLTVDWLTGVDILAPAAGGALGAKHVHSGSTDPADRALFIACRGGGGGNFGVILNYYFNALPNAPRTAYWLTLAYDWSHFTQASFGHFLQTYWDWFSRNDANWNAADPALANGGLFTLLKLQHRSAGPIVLAIQYTGKDGTVGGPEDAPFIDFVDTMNAAANRLPVVWDRFVAPNLPALGHPLAGLRIAHAARSALKMDWLYLTQTINTSGANRRGKYKSAYQIGNFGETEVDALWRYLNGADDPRLSQTLVQIDSYGGCVNANDESANPTSVYQRRSLLKSQYQTYWTNPADDAFHVEWLHDLFSAVHADQGGKPYRDASGRYEGCYINYPDIDMKYLGSDPAQIDPRWLDLYYGDKAASLIATKRSVDPSNLFMHEMSIPLTPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PT8</accession>
    <name>Q63PT8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525689.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109880.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3284"/>
    <dbReference type="EnsemblBacteria" id="CAH37297">
        <property type="protein sequence ID" value="CAH37297"/>
        <property type="gene ID" value="BPSL3284"/>
    </dbReference>
    <dbReference type="GeneID" id="56527862"/>
    <dbReference type="KEGG" id="bps:BPSL3284"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1936"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PNQFAAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266230" evidence="3">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="31"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="380" mass="39760" checksum="2FFB6960F3AAF6DB" modified="2004-10-25" version="1">MNIKMQKLLPISAAAMLLAAAATNAAADQVVKIGHVAPLTGGIAHLGKDNENGARLAVEEINAKGLTIGGQKVTLQLDAQDDAADPRTATQVAQKLVDDKVVAVVGHLNSGTSIPASKIYSDAGIVQISPSATNPAYTQQGFKTTYRVVATDAQQGPALANYARSKGVKSVAVVDDSTAYGQGLANEFEKKAKALGLKVVSHDATNDKAVDFRAILTKIKGENPDAVMYGGMDATGGPFAKQAKQLGLRAKIFAGDGVCTEKLADLAGDATDNVVCSEAGASLEKMPGGAAFKAKYEKRFGQPIQIYAPFTYDAVYIIVDAMKRANSTDPAKIVAAMPKTNYTGVIGTTTFDSKGDLQHGVISLYDYKGGKKTFLDEVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PW8</accession>
    <name>Q63PW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL3254B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109850.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3254B"/>
    <dbReference type="EnsemblBacteria" id="CAH37267">
        <property type="protein sequence ID" value="CAH37267"/>
        <property type="gene ID" value="BPSL3254B"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3254B"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3713"/>
    <dbReference type="eggNOG" id="ENOG503166M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIYVSSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266240" evidence="1">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="14048" checksum="3AFF8D8FB81BA19C" modified="2004-10-25" version="1">MRFCRTTHLGSPMKSTQILASCALVGAVAALAGCAGSSANGPQAESPSGRIIYVASPRSPHDVESCLTSRVSQARVAQRNPTTVLIGPYSADSDWTVTLAPTASSGTTIGVYRPRSGDGDPEESELRFHIARCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PZ3</accession>
    <name>Q63PZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetic acid degradation protein PaaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaB</name>
        <name evidence="1" type="ordered locus">BPSL3231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551024.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109825.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3231"/>
    <dbReference type="DNASU" id="3091479"/>
    <dbReference type="EnsemblBacteria" id="CAH37242">
        <property type="protein sequence ID" value="CAH37242"/>
        <property type="gene ID" value="BPSL3231"/>
    </dbReference>
    <dbReference type="GeneID" id="56594599"/>
    <dbReference type="KEGG" id="bps:BPSL3231"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2006"/>
    <dbReference type="eggNOG" id="COG3460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYRHPTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030200">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02157">
        <property type="entry name" value="PA_CoA_Oxy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="94" mass="10785" checksum="4883EB8ADAD5914D" modified="2004-10-25" version="1">MNNEWPIWEVFVRSKQGLDHKHCGSLHAADASMALRMARDVYTRRREGVSIWVVPSAAITASDPNEKAEMFEPAGDKIYRHPTFYTLPDEVNHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QI4</accession>
    <name>Q63QI4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative molybdopterin-containing oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527789.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109634.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3038"/>
    <dbReference type="EnsemblBacteria" id="CAH37050">
        <property type="protein sequence ID" value="CAH37050"/>
        <property type="gene ID" value="BPSL3038"/>
    </dbReference>
    <dbReference type="GeneID" id="56528155"/>
    <dbReference type="KEGG" id="bps:BPSL3038"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2228"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPLDCPD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02786">
        <property type="entry name" value="MopB_CT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037920">
        <property type="entry name" value="YoaE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="691" mass="75758" checksum="F9A35814EFCC0729" modified="2004-10-25" version="1">MNSPAQFARAVCPHDCPDTCAIRVTVENGRAIKVAGDPDHPPTQGVLCTKVSRYADRVHHPERLTVPLKRVGRKGEGRFEPISWDEANRVMAERLTEIARRAPEAIVPYSYAGTMGLIQGESIAQRFFNKLGASRLERTICSAAGAAGLRYTYGASVGMHFEFFEESEVILIWGANPIASNLHFWTRAQEAKRRGARLIAIDPYRSLTAEKCHQHIALKPGTDGALALGIMHVLISEDLLDRDYIRDHTLGFDALKARALTYTPERVAEICGVTADEVAELARLYGRTRKASIRLNYGMQRVRGGGNAVRAIACLPALTGAWRDRAGGLLLSSSEWAPVDAAAIGRPDLLPGWPNKLPRSINMNAIGDALLHSGDAEFGPRIEAIIVYNSNPVAVAPDSEKVAAGFAREDLFTVVLEHFKTDTADYADILLPATTQLEHLDVHKSYGHTYVMANLPSIAPIGEVRPNTEIFRGIARSMGLDEPALYEDDETLARTSLRWDDASLQSDWDTLKRAGWLKLKLADAPFANGGFRTPSGKCEFYSERLVEMGLDPLPDYLPPYESADGSPELAVRYPLAMISPPARHFLNSTFVNVASLRATEGEPHLDIHPADAARRGVADGDAVRIFNDRGSLRAKARVTDRAREGLVVGLSIWWKKLAPDGRNANQVTSQALTDLGRGATFYDCLVEVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QQ5</accession>
    <name>Q63QQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527760.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109563.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2969"/>
    <dbReference type="EnsemblBacteria" id="CAH36979">
        <property type="protein sequence ID" value="CAH36979"/>
        <property type="gene ID" value="BPSL2969"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2969"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2306"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYLCCKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="27307" checksum="0078900074323CD2" modified="2004-10-25" version="1">MNRLAGKVAIVTGAGRGIGAAIARAFVREGAAVAIAELDAALAEESADAIARDTAGARVLAVPTDVAQAESVAAALARTERAFGPLDVLVNNAGVNVFGDPLALTDEDWRRCFAIDLDGVWNGCRAALPGMVERGRGSIVNIASTHAFKIIPGCFPYPVAKHGVLGLTRALGIEYAPRNVRVNAIAPGYIETQLTHDWWSAQPDPQAARRETLALQPMKRIGRPDEVAMTAVFLASDEAPFINASCITIDGGRSVLYHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QY5</accession>
    <name>MNMA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="1">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmA</name>
        <name type="ordered locus">BPSL2889</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544237.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109483.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QY5"/>
    <dbReference type="SMR" id="Q63QY5"/>
    <dbReference type="STRING" id="272560.BPSL2889"/>
    <dbReference type="EnsemblBacteria" id="CAH36899">
        <property type="protein sequence ID" value="CAH36899"/>
        <property type="gene ID" value="BPSL2889"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2889"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2402"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000349559" description="tRNA-specific 2-thiouridylase MnmA">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="1">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="308"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="1">
        <location>
            <begin position="100"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <sequence length="383" mass="41830" checksum="1A8130E2204CB2D3" modified="2004-10-25" version="1">MTKRRVVVGMSGGVDSSVTAWLLKEQGYDVVGLFMKNWEDDDDGEYCSTRQDWIDVVSVADLIGIDVEAVNFAAEYKDRVFAEFLREYSAGRTPNPDVLCNAEIKFKAFLDHAMSLGAQTIATGHYARVRERDGRFELLKAFDHTKDQSYFLHRLNQAQLSKTMFPLGEIPKTRVREIAAQIGLPNAKKKDSTGICFIGERPFRDFLNRYLPTKPGPMKTPDGKTVGEHIGLAFYTFGQRKGIGLGGSKDGSGEPWFVAAKDIASNTLYVVQGHDHPWLRSRELVAGNVSWVAGEPPADGARCGAKTRYRQADAPCAFGRAAQAGDERFSLVFDEPQWAVTPGQSAVLYDGDVCLGGGIIESAATGRAGTAPAGRAPALVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QY7</accession>
    <name>Q63QY7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P) transhydrogenase subunit alpha</fullName>
            <ecNumber evidence="3">1.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pntAA</name>
        <name evidence="3" type="ordered locus">BPSL2887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194415.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109481.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2887"/>
    <dbReference type="EnsemblBacteria" id="CAH36897">
        <property type="protein sequence ID" value="CAH36897"/>
        <property type="gene ID" value="BPSL2887"/>
    </dbReference>
    <dbReference type="GeneID" id="56593695"/>
    <dbReference type="KEGG" id="bps:BPSL2887"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2404"/>
    <dbReference type="eggNOG" id="COG3288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YFPMLMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="1">
        <location>
            <begin position="145"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="379" mass="39190" checksum="041AD272A3DA6B3F" modified="2004-10-25" version="1">MHIGVPAETRANEARVAATPETVRKYAAAGHRVTVERGAGAGASFPDDAYAAAGAELADAAAAFGADIVLKVQAPTDAECGQLKRGSVLIGMLEPFNAEQAARLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAGTVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETQDERDAAQGVGGYARPMPASWLGRQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRKSGNCPLTVADQVIVHHGVTIAGHTNLAAMVPADASSLYARNLFDFLKLIVTKEGALNIDLSDDIVAATLLCRDGEVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ9</accession>
    <name>Q63QZ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202184.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109469.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2875"/>
    <dbReference type="EnsemblBacteria" id="CAH36885">
        <property type="protein sequence ID" value="CAH36885"/>
        <property type="gene ID" value="BPSL2875"/>
    </dbReference>
    <dbReference type="GeneID" id="56593711"/>
    <dbReference type="KEGG" id="bps:BPSL2875"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2421"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPQATFQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266702" evidence="1">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="186" mass="19694" checksum="5823BBB1CFC9A002" modified="2004-10-25" version="1">MKVSFYRYMLAAFAAASVVVSGAALAQVDLAKSKVSAVSKQMNVPTEGVFKKFSAQIKFDPAKAAQGSAQMTIDVASYDLGDQMYNDQVAGKDWFDAKAYPQASFVSTAIAPAGGNKYNVSGKLTIKGKTVPVTVPVTVTQNGAAQVFDGVLPIKRSTFNVGTGEWKDTSVVADEVQIKFHIVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RA2</accession>
    <name>Q63RA2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KDO 8-P phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11500"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="EC" id="3.1.3.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522192.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109366.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2771"/>
    <dbReference type="EnsemblBacteria" id="CAH36780">
        <property type="protein sequence ID" value="CAH36780"/>
        <property type="gene ID" value="BPSL2771"/>
    </dbReference>
    <dbReference type="GeneID" id="56528426"/>
    <dbReference type="KEGG" id="bps:BPSL2771"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2542"/>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDFHYHG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="19606" checksum="9211495621F59EE1" modified="2004-10-25" version="1">MSAPAYRGAIRLVLFDVDGVLTDGRLHVTGDGECMKSFHAKDGIAVALLHAHGIRSGILSGRHSEALAWRARQLGFDVCVSGCGDKRAGYARIKSEQALADHAIAYVGDDVNDLPVIDAVGVSYAPADAHVLVRRRVDYVVSRAGGEGAAREVAEHVLLRSGLSLDDAYRPLLDEWARHAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RE2</accession>
    <name>Q63RE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109326.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2730"/>
    <dbReference type="EnsemblBacteria" id="CAH36738">
        <property type="protein sequence ID" value="CAH36738"/>
        <property type="gene ID" value="BPSL2730"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2730"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3116"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TTNAWGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="169"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="316" mass="34136" checksum="EADF6A82BF1698B8" modified="2004-10-25" version="1">MRRGIVGIPFRLRFFACAFAMNLSLYAVTVLIWGTTWIAIKWQLGSVPPPVSIAWRFWLAAAAMFVLLRALRRPVRPPRDAWRLLVAQGFALFCVNFLCFYYAEQVVPSGLVAVVFSTAPLLNSINGRLFMGRPLRQSAIAGALLGLIGIGCLFWQQMAGHVDDRATWIGLAIALAGTMSFSAGNLLSSRMQTMGLHPLATNGWAMLIGAAILTAGSIAAGLPLAPDTSPRYLAALVYLAVPGSVIGFTAYLTLIGRIGPERAAYCTVLFPIVALAVSTVFEGYRWSPVAVVGLMLVVAGNLVAFDLTRRRFVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RN6</accession>
    <name>Q63RN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194943.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109232.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2636"/>
    <dbReference type="EnsemblBacteria" id="CAH36644">
        <property type="protein sequence ID" value="CAH36644"/>
        <property type="gene ID" value="BPSL2636"/>
    </dbReference>
    <dbReference type="GeneID" id="56594839"/>
    <dbReference type="KEGG" id="bps:BPSL2636"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2712"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIDFSPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="20420" checksum="47B9FB916708D6E1" modified="2004-10-25" version="1">MFGEIARFLLNTVFTLFGAALLLRVWLQAVRVPPYNPVTQAVLQATNWLVLPLRHIVPGVRGIDWASVVAAVVTSLVYVALMVTMAGVDALSIIPTILVVALLTVVKWALNLVLWLTILMALLSWLNPRSPAMAILYQLTAPLLNPLRRLIPNLGGIDLSPILLFVIVQVLIMIVTRAAVSLTLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR7</accession>
    <name>Q63RR7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSL2604</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109200.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2604"/>
    <dbReference type="EnsemblBacteria" id="CAH36612">
        <property type="protein sequence ID" value="CAH36612"/>
        <property type="gene ID" value="BPSL2604"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2604"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2969"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKAEARD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="12">
        <location>
            <begin position="466"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="483"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH36612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="822" mass="89595" checksum="430A6755F4A565C7" modified="2004-10-25" version="1">MAARAHFGPSRPGVTVIYTWRGGAAFTIDRIERSAGCRRFLAARGRLIAPFDGFMAKAPYTAQAQALPHRMSRLLTEIRWILQVALLAFLLMALLSYSRRDPSWTHAAQVDHIANWAGRVGAWTADIMLLLFGLSAYWLIVLLGRRVAANYRRITRHDALPGEPEKPAGWLAEGFAFVLVLLASDGIEALRMWSLKVQLPRAPGGVVGETVARGVAHALGFTGGTLALLIALAIGLSLYFRFSWLSVAERVGDAIINAFTLAKLRREAERDRKLGEAAAVKREGKVEEERVRIEEHEPVTIVPPVVTPAKSERAEKERQQPLFTDLPGDSTLPAIALLDPAPTSQETISADTLEFTSRLIEKKLKDFGVEVSVVAAYPGPVVTRYEIEPATGVKGSQIVNLSKDLARSLSLVSIRVVETIPGKNFMALELPNQRRQTVRLSEILGSEVYADAPSMLTLGLGKDIGGKPVCADLAKMPHLLVAGTTGSGKSVGINAMILSLLYKASAEQVRLILIDPKMLEMSVYEGIPHLLCPVVTDMRQAGHALNWTVAEMERRYKLMSKLGVRNLAGYNNKIEDAKKREEKIPNPFSLTPDDPEPLGRLPNIVVVIDELADLMMVVGKKVEELIARIAQKARAAGIHLILATQRPSVDVITGLIKANVPTRIAFQVSSKIDSRTILDQMGAESLLGQGDMLYLPPGSGLPVRVHGAFVSDDEVHRVVEKLKEHGEPNYIEGLLEGGTIDGDEGSAAGTGEANGESDPLYDQAVEIVIKNRRASISLVQRHLRIGYNRAARLLEQMEQSGLVSAMSSSGNREILTPARDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RT7</accession>
    <name>Q63RT7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552538.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109180.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2583"/>
    <dbReference type="EnsemblBacteria" id="CAH36591">
        <property type="protein sequence ID" value="CAH36591"/>
        <property type="gene ID" value="BPSL2583"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2583"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2945"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="181" mass="20618" checksum="7BBBB4C8F81E330F" modified="2004-10-25" version="1">MTARVIKFRTRSGEDLDVAVDGVHHPAVQAIKEIHRKGRQPFNEARPTGPWIERHEYQARVRNGRLEFREGTRRGAWSKKLPGQQFLEMEERKFRGAQHRASGQARASAAGVTARRKGAEGLADRIVAEFNRLGERVPPMPIHNRTAEIARLVDKSKVHVMNVLVDRGLRAPRIKIQTNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SQ5</accession>
    <name>Q63SQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108861.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2265"/>
    <dbReference type="EnsemblBacteria" id="CAH36268">
        <property type="protein sequence ID" value="CAH36268"/>
        <property type="gene ID" value="BPSL2265"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2265"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3165"/>
    <dbReference type="eggNOG" id="COG2833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRFAGMP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007402">
        <property type="entry name" value="DUF455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011197">
        <property type="entry name" value="UCP012318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04305">
        <property type="entry name" value="DUF455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012318">
        <property type="entry name" value="UCP012318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="283" mass="30971" checksum="D5271EA7E21EF967" modified="2004-10-25" version="1">MSSVPISSSEPLRCARSAALAALGESDPARKVALVAELHAALADGRAAVFPERELSAPARGVPGRPARPELVEPRRLERRSMRSPQGRAVLLHALAHIEFNAINLALDAVWRFARMPTAFYADWLKVAAEEAHHFSLLAARLAEFGHAYGDFPAHDGLWEMCERTAGDVLARMALVPRTLEARGLDASPPIRARLQQAGDHASAAILDVILRDEIGHVWIGNRWFRHLCDAAGLDPHPTYERLAGQYRAPRLRGPFNFDARRAAGFNDDELNALVAQDADPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T64</accession>
    <name>Q63T64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521233.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108702.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2105"/>
    <dbReference type="EnsemblBacteria" id="CAH36108">
        <property type="protein sequence ID" value="CAH36108"/>
        <property type="gene ID" value="BPSL2105"/>
    </dbReference>
    <dbReference type="GeneID" id="56529091"/>
    <dbReference type="KEGG" id="bps:BPSL2105"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3367"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIFRAKA"/>
    <dbReference type="PHI-base" id="PHI:7563"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="226" mass="24464" checksum="3AB3D9CFAF965F34" modified="2004-10-25" version="1">MSLFDSISRTIKGLLNDAADSVQDPSRDARQIVRELDDSIGRAENSLIEIEAQVATQRSKRDTADERAKKYEDGAKRALQSGDEALAREALAAQANAEAERDALARELDTLEPSVDKLKGQIADMRARRNDLNARSNILQAKQEIAQAKDVAATALGGIGGKNLSEDFQKLEDKVALSNARSDARLNSADTNSGRALDDKLAALNKGPSVEDRLEALKKQLNTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TA5</accession>
    <name>Q63TA5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521783.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108661.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2062"/>
    <dbReference type="EnsemblBacteria" id="CAH36063">
        <property type="protein sequence ID" value="CAH36063"/>
        <property type="gene ID" value="BPSL2062"/>
    </dbReference>
    <dbReference type="GeneID" id="56526425"/>
    <dbReference type="KEGG" id="bps:BPSL2062"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.49"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KICGEQP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267536" evidence="4">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="108"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="24698" checksum="48125E0B5C108A5A" modified="2004-10-25" version="1">MFKTIVLAACAAAVLGACTSATGPRFNAYVLSDAAGAKTYKVECHGLFEGPGVCRDKAREICADKDVHVLTGVGPLGHDDDVRTLAFQCGEPAQPVAQQPQPAPAAAPAAEPIRLNADAMFAFDRADAASMTEQGRQQLSQLAQRLTDRHAQTVSIVGYTDRLGSDAYNRQLSQARAKTVGDYLIAAGVPADSVHAEGRGASDPLVQCDQRERAALIACLAPNRRVEVVAAGLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TC0</accession>
    <name>Q63TC0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009930792.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108646.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2048"/>
    <dbReference type="EnsemblBacteria" id="CAH36048">
        <property type="protein sequence ID" value="CAH36048"/>
        <property type="gene ID" value="BPSL2048"/>
    </dbReference>
    <dbReference type="GeneID" id="56526411"/>
    <dbReference type="KEGG" id="bps:BPSL2048"/>
    <dbReference type="eggNOG" id="ENOG5032WTF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEWRDDE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021733">
        <property type="entry name" value="DUF3304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11745">
        <property type="entry name" value="DUF3304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266568" evidence="1">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="197" mass="21744" checksum="D129FED41504BDBA" modified="2004-10-25" version="1">MNKCFVKLNGLIALFVFAILMCGGCSRTSQSSSDEAEMKHEVTSSSESEVMSLNLNALNYTEIPIGKFYVDGTWGGNVRSRIGSGGLGILCCVSLPKKWRPGLTVTVEWRDDEMYKNDPNSLTSRVVPVEKYEYFSDGFLWVLFFPGGKIKAYASQWMPGFPGFPEGLQAPNVACPGHFTLLNSDPRCPAPDNRIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TE6</accession>
    <name>Q63TE6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative drug-resistance related outer-membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108620.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2022"/>
    <dbReference type="EnsemblBacteria" id="CAH36021">
        <property type="protein sequence ID" value="CAH36021"/>
        <property type="gene ID" value="BPSL2022"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2022"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2283"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWSSHFY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="526" mass="55857" checksum="8CC83939B3001733" modified="2004-10-25" version="1">MTATSTSSASSASSAASPPAAGSGAPNAGAPPRSLPTVEADPDPRWWRTFGDPVLDRLVERAAQDNLDVQAAVLRIAEARAQVRAAAAQGLPDVRASASYQREQLGLKGFLEDGGVDAQLERLGAPGSPLERIAPGAGAALRRGAEHTLDQLTSPVNLWQAGFDASWELDLFGRVRRSVEAAGAQTQAAIEGRNDALLSLEAEVAQTYLQLRGAQALRTLAVALADEQRDVVALTRDQARKGLSSELDVQSADARLAQLRAQLPQFDQQIALLRNGLSYLLGDAPGALDDALREPRALPELPPTVPIGLPSTLARRRPDIRRAEAQLHAATAGVGVAVAQFYPDVSLTGQVGTRATHARELAHWSHLFYAFGPSVSLPIFEGGALVANLRLSQAQQAQAALGYRRAVLLALRDVDNALAAYRTDQTRRDALRDAAAAERTTFELARDSYRHGLVSFIDVLDAERELSQARQQYVQGSLQLTTDLVSLYKALGGGWQPVPAAQTPAPAALDAPTQDTPLGATAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH5</accession>
    <name>Q63TH5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193469.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108591.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1993"/>
    <dbReference type="EnsemblBacteria" id="CAH35992">
        <property type="protein sequence ID" value="CAH35992"/>
        <property type="gene ID" value="BPSL1993"/>
    </dbReference>
    <dbReference type="GeneID" id="56595404"/>
    <dbReference type="KEGG" id="bps:BPSL1993"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4145"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LHQHTEG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="28510" checksum="439B8F38D62B0DD2" modified="2004-10-25" version="1">MSTPASHDTILALENVSKYFGKVIALSGVTLRVKRGEVHCLLGDNGAGKSTLIKTLAGVHPPSDGQYLVDGKPVLFDSPKDALDLGIATVYQDLALVPLLSVARNFFMGREPQKKLFGLFNVMDLDSSARIARAKLAEMGINVRDAHQPIGTMSGGERQCLAIARAIHFGARVLILDEPTAALGVKQSLNVLKLIHAARAKGISVIFITHNVHHAYPIGDSFTLLNRGRSLGTFTKDTISKNEVLDMMAGGAEMQKMIAELDGATI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TV5</accession>
    <name>Y1862_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0303 protein BPSL1862</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL1862</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0303 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199466.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108461.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TV5"/>
    <dbReference type="SMR" id="Q63TV5"/>
    <dbReference type="STRING" id="272560.BPSL1862"/>
    <dbReference type="EnsemblBacteria" id="CAH35861">
        <property type="protein sequence ID" value="CAH35861"/>
        <property type="gene ID" value="BPSL1862"/>
    </dbReference>
    <dbReference type="GeneID" id="56595653"/>
    <dbReference type="KEGG" id="bps:BPSL1862"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3996"/>
    <dbReference type="eggNOG" id="COG4702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWIDRKR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000046743" description="UPF0303 protein BPSL1862">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00761"/>
        </source>
    </evidence>
    <sequence length="165" mass="17344" checksum="C92B234A7D5DFFEA" modified="2004-10-25" version="1">MDIALDLQSIAVQEKTLVFPQFDAARAWALGSQLREFALARGHAVAIDVRTFGQPLFFALVDGATPDNVDWARRKGNVVAHFRRSSYAIGLRLQQAGATLADKHGLPAAEYASHGGAFPIAVAGAGVIGSVTVSGLPQRGDHELVVEALCAQLGHAYATLALTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TY2</accession>
    <name>Q63TY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator Cbl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbl</name>
        <name evidence="3" type="ordered locus">BPSL1835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193901.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108434.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1835"/>
    <dbReference type="EnsemblBacteria" id="CAH35834">
        <property type="protein sequence ID" value="CAH35834"/>
        <property type="gene ID" value="BPSL1835"/>
    </dbReference>
    <dbReference type="GeneID" id="56595620"/>
    <dbReference type="KEGG" id="bps:BPSL1835"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3961"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FERYGKR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08413">
        <property type="entry name" value="PBP2_CysB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037423">
        <property type="entry name" value="CysB_PBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="308" mass="34296" checksum="21E8C41BCD1ACF64" modified="2004-10-25" version="1">MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLTEPGKAVHQLIERMLLDAENLRRVARQFADQDSGHLVVATTHTQARYALPKVIRQFTEVYPKVHLALRQGSPQQIAQMILNGEADLGISTEALDRFPDIVTFPCYSWHHVVVVPKGHPLVGRENVTLDDIAEYPIITYDQDFTGRSHIDQAFANAGAVPDVVLTAIDADVIKTYVELGMGIGVVAAMAYDAQRDTGLVALDTQHLFEASTTRVGLRRGAFLRAYAYRLIEMFAPHLSEGEIAGQLREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U26</accession>
    <name>Q63U26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521577.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108390.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1791"/>
    <dbReference type="EnsemblBacteria" id="CAH35790">
        <property type="protein sequence ID" value="CAH35790"/>
        <property type="gene ID" value="BPSL1791"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1791"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2014"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDVWNKR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="34156" checksum="15D2E7C8620C8973" modified="2004-10-25" version="1">MHDRTAAPSASCASAAASPARATGPARAAHALAALRRSTTFYPLVGLVAVCVAMVFASDSFLSAANLENVLRQVSINAIIGVGMTCVILTGGIDLSVGSVMALSGTLAAGLLVAGANGAAALAAGIGVGVALGAANGLFVAFAGMPPIIVTLATMGIARGLALIYTGGYPIDGLPDWIRFFGSGKVLGVQMPVLTMLAVYALAWLMLERMPFGRYVYAIGGNEHATRLSGVRVSRVKLAVYTFAGLTSALAALVLTGRLMSGQPNAGGGFELDAIAAVVMGGTSIAGGRGSIVGTLVGALLLGVLNNGLNMIGVNPYVQNVIKGAIILLAIYIGRERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U28</accession>
    <name>Q63U28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191609.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108388.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1789"/>
    <dbReference type="EnsemblBacteria" id="CAH35787">
        <property type="protein sequence ID" value="CAH35787"/>
        <property type="gene ID" value="BPSL1789"/>
    </dbReference>
    <dbReference type="GeneID" id="56595575"/>
    <dbReference type="KEGG" id="bps:BPSL1789"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2010"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INMTRAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="25432" checksum="77703A1AA45C72AE" modified="2004-10-25" version="1">MSVAFDFHGRSFLVTGASSGIGRAAAVALRGGGARVVAAARNARELERLAHETGCEPLELDVGCDASVRAALSGERMRDAFDGLINCAGVTSLAAAIDTTADEFDRVMAVNARGAMLVARHVARAMIRAGRGGSIVNVSSQAALVALPSHLAYCASKAALDAMTRVLCVELGPHGIRVNSVNPTVTLTPMAERAWSDPHASGPMLAAIPLGRFARVADVVAPILFLSSDAAAMVSGVALPVDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UA7</accession>
    <name>Q63UA7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527008.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108309.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35706">
        <property type="protein sequence ID" value="CAH35706"/>
        <property type="gene ID" value="BPSL1708"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1708"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266784" evidence="1">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="142" mass="15374" checksum="DEEC6864612B4250" modified="2004-10-25" version="1">MNEDNMKSVTRTIRIAVAVSATCALAARASVPSAEVEAAAAFAPPRLLKVSGALRQPLTTKGEAPIASGTSRRDQEIMELRRRFNAAADPVTHRMSLARARQTGWDGVAKHFSEIDQSGQGTVSFDELALYLRNQRHPAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UJ9</accession>
    <name>Q63UJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539929.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108217.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1601"/>
    <dbReference type="EnsemblBacteria" id="CAH35601">
        <property type="protein sequence ID" value="CAH35601"/>
        <property type="gene ID" value="BPSL1601"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1601"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3660"/>
    <dbReference type="eggNOG" id="ENOG50337BE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REYAMDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="134" mass="14872" checksum="22108AF822876AB3" modified="2004-10-25" version="1">MLHIELKERIETEFETARVESVTLRRDALDVRLANGVELTLRIANAREYAMDWRWGEAAMRIDTAPRHAPPEAAHPNHLHAPDGRVLADPVTEFGGEPWRNVRALIERLAAAPLLGHEPPSAHGLPSDARAIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UL6</accession>
    <name>Q63UL6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544501.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108200.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1580"/>
    <dbReference type="EnsemblBacteria" id="CAH35581">
        <property type="protein sequence ID" value="CAH35581"/>
        <property type="gene ID" value="BPSL1580"/>
    </dbReference>
    <dbReference type="GeneID" id="56529305"/>
    <dbReference type="KEGG" id="bps:BPSL1580"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3631"/>
    <dbReference type="eggNOG" id="ENOG50316GS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWVAMRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021389">
        <property type="entry name" value="DUF3022"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11226">
        <property type="entry name" value="DUF3022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="120" mass="13581" checksum="51C51A0522471321" modified="2004-10-25" version="1">MDDYQYDCASAEFGELARVICDLFPEQTRFAERADEAGRLLSVHWLAMRFGATPRKTTLDVRFTSAALRRYLALKPMQRARSHAVLRAYVEATLGSLEERHAAGETVPRETTLELGDEFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UT6</accession>
    <name>NDK_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name type="ordered locus">BPSL1510</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193561.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108130.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UT6"/>
    <dbReference type="SMR" id="Q63UT6"/>
    <dbReference type="STRING" id="272560.BPSL1510"/>
    <dbReference type="EnsemblBacteria" id="CAH35511">
        <property type="protein sequence ID" value="CAH35511"/>
        <property type="gene ID" value="BPSL1510"/>
    </dbReference>
    <dbReference type="GeneID" id="56595751"/>
    <dbReference type="KEGG" id="bps:BPSL1510"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3547"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000136959" description="Nucleoside diphosphate kinase">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <sequence length="141" mass="15562" checksum="5A7684CDD1C9A18E" modified="2004-10-25" version="1">MALERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVAARMAHLSRADAEKFYAVHAERPFFKDLVDFMISGPVMIQVLEGEDAILKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETARAEVAFFFPEMNVYSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V08</accession>
    <name>KTHY_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmk</name>
        <name type="ordered locus">BPSL1436</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527198.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108058.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V08"/>
    <dbReference type="SMR" id="Q63V08"/>
    <dbReference type="STRING" id="272560.BPSL1436"/>
    <dbReference type="EnsemblBacteria" id="CAH35438">
        <property type="protein sequence ID" value="CAH35438"/>
        <property type="gene ID" value="BPSL1436"/>
    </dbReference>
    <dbReference type="GeneID" id="56529159"/>
    <dbReference type="KEGG" id="bps:BPSL1436"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3458"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155253" description="Thymidylate kinase">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <sequence length="206" mass="23128" checksum="B59FB6203FA691D9" modified="2004-10-25" version="1">MARGKFITFEGIDGAGKTTHLQWFCDRLQERLGPTGRHVVVTREPGGTQLGETLREILLNQPMDLETEALLMFAGRREHLALVIEPALARGDWVVSDRFTDATFAYQGGGRGLPRDKLEALERWVQGGFQPDLTVLFDVQPQVASARRGAVRMPDKFESESDAFFARTRAEYLRRAHEAPHRFAIVDSSESIPQIRRQLEGVLAAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V42</accession>
    <name>TIG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trigger factor</fullName>
            <shortName evidence="1">TF</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tig</name>
        <name type="ordered locus">BPSL1402</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521257.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108024.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63V42"/>
    <dbReference type="SMR" id="Q63V42"/>
    <dbReference type="STRING" id="272560.BPSL1402"/>
    <dbReference type="EnsemblBacteria" id="CAH35403">
        <property type="protein sequence ID" value="CAH35403"/>
        <property type="gene ID" value="BPSL1402"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1402"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3414"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000179329" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="1">
        <location>
            <begin position="173"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <sequence length="449" mass="49768" checksum="FB76C87E7BDDAF54" modified="2004-10-25" version="1">MANVVENLGKLERRVTISLPKDVVQKEIDARIQKLAKNVRMPGFRPGKVPLKMVAQQYAGQVEAEVLSDKIGQEFFTISRAENLRVAGQPSFAPKEDTQQESTYAFDATFEVYPEVKIGDLATAEVERSTTTIGDAEIDRTLDILRKQRVHFHARGEGGEHGDGGADTAAQNGDRVTVDFVGKIDGVAFQGGTAEDFVFVLGEGRMLPEFETAALGLKAGESREFDLKFPDDYHGKDVAGKTAQFTVTLKKVEWPHLPEIDADFAKSLGVEDGDLTKMRAEIKENLEREAKRRTQSIVKNQVMDALLKISELDVPKALIEQDQQRLVEMARQDLAQRGVPNAKDAPIPAEMFADQAERRVKLGLVLAELVKANGLEAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAFVVESNVVDFVLGKAKVTDKEVSFEALASATAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VR5</accession>
    <name>Q63VR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204961.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107801.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1179"/>
    <dbReference type="EnsemblBacteria" id="CAH35174">
        <property type="protein sequence ID" value="CAH35174"/>
        <property type="gene ID" value="BPSL1179"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1179"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.353"/>
    <dbReference type="eggNOG" id="COG3127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIMWRLS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="880" mass="92005" checksum="56FF6D7436E1F2E9" modified="2004-10-25" version="1">MTAAGKARPAGRRFGLVDLLRQAGRMTLRDWRAGELTLVALALVLAVAALTSVGFLADRLRQGLERDARRMLGADFVVRADHPVDPAFAHEARTLGLATATTAVFPSMVGAAKPAGSAGSAGSAKAGTPAPSAAADGAGSSPPVRLAAVKAVSAGYPLRGAVEIAPEANAPGRAAGSIPASGTVWVDPSLLDALHLKVGDALRVGGRTFTIGAAITRELDRGFSFVNFSPRVMLRADELESTGLTGYGSRVTYRLLVAGDDAAVERFARYAHARVDGGKLRGVALESLQEGQPQVRQTLDRARHFLTLVALLTALLAAVAIAMAAQRYMRRHLDGCAAMRCLGASRRTLSALFAIEFALLGLAGGAAGAALGYVGHLVLLRALGSLIDVVLPPPSAWPAAIGVGTGLVLLLGFALPPLAPLTRVPPVRVLRREWGDAGRVAWVGYAMGIALFAALLIAAAGNLTLGAIVAGGFAGSLVLFALIARLALVALARLVRDGRVAAGLGWRHALASLERRGAASALQITALALGLMCLLLIAITRNDLVAGWRQSTPPDAPNQFLIDIQPDQRDDVVRYLAANGIADPALSPMVRGRLVAVNGKPVNPDDYKRDDARRLVDREFNLSYTTRLPEDNRLVAGDWFGASGVPQISIEAGLAKTLGVKTGDTLRFDVTGLTVDAPVTSVRKLDWGTFRVNFFVLMPPAALRDFPATYITSFHLPAARERVLDGLIARYPNLTAIDVGPILAQLERVLLQVIGAVQFLFGFTLAAGVLVLYTALAGSRDERVREAALMRALGASRKQVVAVQRAEFVVVGVLAGAMAAAGALVVGAVLASRVFDFQLAPDPWLVPAGIAAGVACAGAAGWLGLRGVQRRPALQSLRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VY9</accession>
    <name>Q63VY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative depolymerase/histone-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204945.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107727.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1106"/>
    <dbReference type="ESTHER" id="burma-q62ie8">
        <property type="family name" value="PHB_depolymerase_PhaZ"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35099">
        <property type="protein sequence ID" value="CAH35099"/>
        <property type="gene ID" value="BPSL1106"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1106"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.448"/>
    <dbReference type="eggNOG" id="COG4553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FYLQTVE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009656">
        <property type="entry name" value="PHB_depo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010915">
        <property type="entry name" value="PHB_depoly_PhaZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06850">
        <property type="entry name" value="PHB_depo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020818">
        <property type="entry name" value="PHB_depoly_PhaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01849">
        <property type="entry name" value="PHB_depoly_PhaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB_depo_C" evidence="2">
        <location>
            <begin position="211"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="488" mass="54189" checksum="2D350A36C8705D80" modified="2004-10-25" version="1">MLYQFHEFQRAMLSPLTAWAQAASKSFANPSSPLSLVPGATRLAAGYELLYRLGKDYEKPEFGIHQIVKDGHNIPIVEQTIIEKPFCRLLRFKRYADDSGAVGQLKDEPVVLVCAPLSGHHATLLRDTVRTLLQDHKVYITDWIDARMVPAEVGSFHLDDYVGYIQKFIRHIGARNLHVISVCQPTVPVLAAISLMASRGEDTPLTMTMMGGPIDARKSPTSVNSLATNRSHSWFENNVIHTVPANYPGEGRKVYPGFLQHTGFVAMNPERHAQSHWDFYQSLLRGDEEDAEAHRRFYDEYNAVLDMAAEYYLDTIRIVFQEFRLAEGTWDIHGERVKPADIHSTALMTIEGELDDISGSGQTHVAHELCTGIEQAHRRSLTAEKCGHYGIFSGRRWRTIIYPQLRDFIREHASQPKKPTPQAGPTPNSPSTPSRSASGSETASAAPAKAAALKLSAKRTAAKTRAAKPHAAKRGAIKLAAPRTRKAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W73</accession>
    <name>HEM3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Porphobilinogen deaminase</fullName>
            <shortName evidence="1">PBG</shortName>
            <ecNumber evidence="1">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="1">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemC</name>
        <name type="ordered locus">BPSL1015</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="1">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193185.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107643.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63W73"/>
    <dbReference type="SMR" id="Q63W73"/>
    <dbReference type="STRING" id="272560.BPSL1015"/>
    <dbReference type="EnsemblBacteria" id="CAH35011">
        <property type="protein sequence ID" value="CAH35011"/>
        <property type="gene ID" value="BPSL1015"/>
    </dbReference>
    <dbReference type="GeneID" id="56596173"/>
    <dbReference type="KEGG" id="bps:BPSL1015"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.553"/>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000142918" description="Porphobilinogen deaminase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <sequence length="329" mass="34409" checksum="25D5AFCE236891B1" modified="2004-10-25" version="1">MNSETLPAELPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLAVHSLKDVPMALPEGFALAAVMSREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARHPRLDVRPLRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAVSRALGGSCEVPLAAHAVWRGGELHLTGSVSTTDGARVLAAHAHARAATAADALALGRRVSDALERQGARAIVDALVAASAQAQKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WA0</accession>
    <name>Q63WA0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198617.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107616.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0988"/>
    <dbReference type="EnsemblBacteria" id="CAH34984">
        <property type="protein sequence ID" value="CAH34984"/>
        <property type="gene ID" value="BPSL0988"/>
    </dbReference>
    <dbReference type="GeneID" id="56596202"/>
    <dbReference type="KEGG" id="bps:BPSL0988"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.586"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NNGYEYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="138" mass="14314" checksum="B2336B598902556E" modified="2004-10-25" version="1">MDSNRLNDAGAALLRIALGVLYLAHVAQKLFVFTLPGTAQFFASVGLPGWLAYVTTFVELAGGLALLAGVRVRLVSLVLLPFMLGATMTHFPNGWSFAAPHGGWEYPAFWAVTLVVQALVGAGAFALGGARGAAGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WG4</accession>
    <name>Q63WG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536444.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107552.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0924"/>
    <dbReference type="EnsemblBacteria" id="CAH34919">
        <property type="protein sequence ID" value="CAH34919"/>
        <property type="gene ID" value="BPSL0924"/>
    </dbReference>
    <dbReference type="GeneID" id="56526894"/>
    <dbReference type="KEGG" id="bps:BPSL0924"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.656"/>
    <dbReference type="eggNOG" id="COG5634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GILIHFE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="222" mass="23928" checksum="F12199CFD3A2FB90" modified="2004-10-25" version="1">MSLDYGFVKAKIKAVAGLKAAARANETQYHVHLTLALPDGDWDVAINVGTNDADDLLKYKLVYDFHHPVTQTLAAAAEGYTDLTGGDALPALDYVRSDVLNETGGWRMSDVMDGTEHPEPIPSVLRLVDAAHQQNLDLYVFGRTYVEGNGIHDTHMNQGSSGPHFLHRPGVDTNDHNDVWQDGALLVDLGGPQWAAYFAAFEQQAVPTDGLGNPLPGAGPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WL0</accession>
    <name>Q63WL0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550786.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107506.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34873">
        <property type="protein sequence ID" value="CAH34873"/>
        <property type="gene ID" value="BPSL0881"/>
    </dbReference>
    <dbReference type="GeneID" id="56526941"/>
    <dbReference type="KEGG" id="bps:BPSL0881"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.951"/>
    <dbReference type="OMA" id="GSWRYAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266642" evidence="2">
        <location>
            <begin position="25"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="422" mass="43964" checksum="FEA466B8601CAF4E" modified="2004-10-25" version="1">MALSRGTRTLIGATLCASVTLMTAACGGSDGSGAPGASIFKSPHGSGSSSTTGTSGTTTSGTGGTSTGSTQTTMALQMADFILAQQDSNGAIPDEAGSGTANTDSDMEYALIGLAAAYGATHDAKYLNGLEKGIAWLAAREEMTDPAWRGSWRYVYSMTPPYDPIPTSPGAGIADVRGVDATSALFVYLLYLDRQLTGSSALVTQYGANARAALDFVLAKNINPSGYSGSSWQLPVGSTTWQFWPYEYAADQGDVYLGMNGGALLFPDNPNYAAKAAFLRNNVPSQFYMTGAQRYSVGRDTGAPLDSDLGIDTIFPQGYLPWVFGANSQSIGSIQWMINQTAADGSIRSPSTDPAYALSNVILLLGAPTQGMQAPSTTLPWIVNNVLDPQTYGIHDYPGSPDQETNVSGFAVAALLGTKAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WR1</accession>
    <name>Q63WR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530860.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107455.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0831"/>
    <dbReference type="EnsemblBacteria" id="CAH34822">
        <property type="protein sequence ID" value="CAH34822"/>
        <property type="gene ID" value="BPSL0831"/>
    </dbReference>
    <dbReference type="GeneID" id="56526990"/>
    <dbReference type="KEGG" id="bps:BPSL0831"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.770"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="288" mass="31418" checksum="EAC33BF227539F8B" modified="2004-10-25" version="1">MSDLTVSTPRGAFGAPRAALGALKRALPGLLAWLVALALFFPIFWMAITAFKTEQQAYSSALFFVPTLDSFREVFARSNYFAFAWNSVLISAGVTVICLLLAVPAAYAMAFFPGRRTQKVLLWMLSTKMMPSVGVLVPIYLMWKNAGLLDTVSGLVIVYTLINLPIAVWMTFTYFNEIPKDILEAGRIDGASTWQEIVYLLMPMALPGLASTALLLVILSWNEAFWSINLSSSNAAPLTVFIASYSSPEGLFWAKLSAASLLAVAPILVVGWLSQKQLVRGLTFGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WU7</accession>
    <name>Q63WU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AzlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522683.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107419.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0794"/>
    <dbReference type="EnsemblBacteria" id="CAH34786">
        <property type="protein sequence ID" value="CAH34786"/>
        <property type="gene ID" value="BPSL0794"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0794"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.811"/>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLSWQVS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="249" mass="26614" checksum="79C75224AC12AC2A" modified="2004-10-25" version="1">MLARLSATDRFALAQGFRDFSPTLMAILSWGLVTGIAMSKSVLTTGQALGMSILVYAGSSQLAVLPLFAAKLPVWTILLTAAMVNMRFVIFSAGLAPHFSYLPLWRRLAIGYFNGDVIYLLFQKQGFAAGHVPGKEAYFWGMALTSWFAWQASSLVGIALASAFPDSWGLALAGTLALIPIMVSAISNRSTLAAVAVAGIVSLVAFDLPYRLALPLAVVAALAAGSAADWFVERADWRRIRAAHTEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X70</accession>
    <name>Q63X70_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="10">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="10">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">glyS</name>
        <name evidence="12" type="ordered locus">BPSL0667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189008.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107296.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0667"/>
    <dbReference type="EnsemblBacteria" id="CAH34660">
        <property type="protein sequence ID" value="CAH34660"/>
        <property type="gene ID" value="BPSL0667"/>
    </dbReference>
    <dbReference type="GeneID" id="56596638"/>
    <dbReference type="KEGG" id="bps:BPSL0667"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.953"/>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPIPKRM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="594"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="699" mass="75955" checksum="AC21D7989BF1639D" modified="2004-10-25" version="1">MTQNHSASLLVELLTEELPPKALARLGDAFAEGIAQRLAARDLIEGELAFERYATPRRLAVVVQNVRAVAPERQVREKVLPVSVALDAQGAPSAPLAKKLAALGHPNLSIADLERAHDGKAEAFFVNYAAPGATLADGLQAALDETLAKLPIPKVMTYQRPDGTDVQFVRPVHRLTVLHGDRIVPVAAFGIDAGDTTLGHRFLSDGLVAIRHANAYADTLREKGRVLAHFAQRRETIRTQLEANANGDRVVMPEALLDEVTSLVEWPVVYPCRFEDEFLQVPQECLILTMQTNQKYFALTDAAGKLRSRFLIVSNIETKTPGEIVEGNERVVRPRLADAKFFFEQDKKKPLAERVPLLANVVYHNKLGSQLARVERLETLAGEIAPAIGADATVAIRAARLAKADLLTDMVGEFPELQGTMGTYYARHDGEPEDVAIACSEHYQPRFSGDALPTTPVSTAVALADKLETIVGIWGIGLAPTGEKDPFALRRHALGVLRLLLEKQLPLDLVWLLRTAYERFAAVPGVAESTDAIHAFFIDRLRGLLRERGYTAGEIDAVLSLNPTRLDDIVARLNAVREFTRLAEAEALAAANKRISNILKKSESGANGAVQPALFVEAAEKALAEQLADVTPRVQSQLEARAYTGALTALAALRAPVDAFFDGVMVNADDPALRANRLALLSALHQQMNCVADISKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X77</accession>
    <name>Q63X77_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.262</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(phosphohydroxy)-L-threonine dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">pdxA</name>
        <name evidence="5" type="ordered locus">BPSL0660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32275"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="EC" id="1.1.1.262"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The active site is located at the dimer interface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PdxA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.262" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009970136.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107289.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0660"/>
    <dbReference type="EnsemblBacteria" id="CAH34653">
        <property type="protein sequence ID" value="CAH34653"/>
        <property type="gene ID" value="BPSL0660"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0660"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.960"/>
    <dbReference type="eggNOG" id="COG1995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TAQVVMM"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00536">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037510">
        <property type="entry name" value="PdxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="349" mass="36367" checksum="C8B6088FF1743404" modified="2004-10-25" version="1">MSDRPQPLRIAITTGEPAGVGPELTARALADAATRWPDARFTVLGDAGLIAARAAAVGLDWTRMTAAGGGAHVANAHVANAHVTVAHVTVAHRALAAPAEAGKLNPANGRYVLDLLDAAIDGALAGEYDAIVTAPLQKSTINDAGVPFTGHTEYLAERTRTPHVVMMLAGTGERPLRVALATTHLPLRDVSAALTIDGLADTLSIIDRDLRGSFGLAAPRILVTGLNPHAGEHGYLGREEIDVIEPALERARAAGIDARGPYPADTLFQPRYLEHADCVLAMFHDQGLPVLKYATFGEGINVTLGLPIIRTSVDHGTALDLAGTGRADPGSLVAAIDTAVTMARHRRAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XW5</accession>
    <name>DCTA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C4-dicarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dctA</name>
        <name type="ordered locus">BPSL0425</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526010.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107050.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XW5"/>
    <dbReference type="SMR" id="Q63XW5"/>
    <dbReference type="STRING" id="272560.BPSL0425"/>
    <dbReference type="EnsemblBacteria" id="CAH34413">
        <property type="protein sequence ID" value="CAH34413"/>
        <property type="gene ID" value="BPSL0425"/>
    </dbReference>
    <dbReference type="GeneID" id="56527331"/>
    <dbReference type="KEGG" id="bps:BPSL0425"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1236"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLYIAVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006835">
        <property type="term" value="P:dicarboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01300">
        <property type="entry name" value="C4_dicarb_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023954">
        <property type="entry name" value="C4_dicarb_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0769">Symport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000067440" description="C4-dicarboxylate transport protein">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01300"/>
        </source>
    </evidence>
    <sequence length="428" mass="45261" checksum="7DBDC0232FC326EE" modified="2004-10-25" version="1">MKKPFYKVLYVQVIFAIVVGVILGHYYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLYFEIVSTCALVLGLAATHILRPGVGFNIDPATLNGKEVASYAAKAHGQSSVDFLMHIIPNTMIDAFAQGEILQILLIALLFGSVLAHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLGAIARFTGFSIIRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSAWEKELDRAKLRAALSGNGEAAAGEAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y53</accession>
    <name>Q63Y53_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106962.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0335"/>
    <dbReference type="EnsemblBacteria" id="CAH34324">
        <property type="protein sequence ID" value="CAH34324"/>
        <property type="gene ID" value="BPSL0335"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0335"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1346"/>
    <dbReference type="eggNOG" id="COG3565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFLEDPF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="137" mass="15127" checksum="744E8C89F8B39A17" modified="2004-10-25" version="1">MRPFHLAFPVTSLEHARRFYGGLLGCPEGRSSDHWVDFDFFGHQLVAHLAPGETGRSAVNPVDGDDVPVRHFGVVLSMDEWHALADTLKAAGTRFVIEPHIRFKGEAGEQATMFFVDPCGNALEFKAFADIGQLFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y56</accession>
    <name>Q63Y56_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525946.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106959.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0332"/>
    <dbReference type="EnsemblBacteria" id="CAH34321">
        <property type="protein sequence ID" value="CAH34321"/>
        <property type="gene ID" value="BPSL0332"/>
    </dbReference>
    <dbReference type="GeneID" id="56527424"/>
    <dbReference type="KEGG" id="bps:BPSL0332"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1349"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMLPATG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="168" mass="17501" checksum="C79DE3F959981D84" modified="2004-10-25" version="1">MATPAPIDKLPDSARRVALLLRERGHAKAIVMLEETGKTSAEAAAGLGCSIAQIAKSILFRRRADGAPVLVVASGANRVDERKVAAQVGEVGRADAKFVRDNTGYAIGGVCPIGHLVEPVVLIDRDLLDLDSLWAAAGHPHAVFNLSPQELVSLTGAPVADVAQRGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y57</accession>
    <name>Q63Y57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530999.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106958.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0331"/>
    <dbReference type="EnsemblBacteria" id="CAH34320">
        <property type="protein sequence ID" value="CAH34320"/>
        <property type="gene ID" value="BPSL0331"/>
    </dbReference>
    <dbReference type="GeneID" id="56527427"/>
    <dbReference type="KEGG" id="bps:BPSL0331"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1351"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGWLVMS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="31926" checksum="2C3C8FD1EC5759EB" modified="2004-10-25" version="1">MASNPASSDARRGALEMVVAMLMSGTIGWLVVSSRQHLMNVVFFRCLFGGATMLIICAALGLLRRDLLTKRTIAFALLGSVAIVANWVLLFAAYSRASISMATAVYNTQPFMLVALGALVFRERLTASAAAWLVLAFGGLALVVRVEPAVLAVPGEYLEGVALALGAAFLYAVSSIVTKRLKGTPPHLIALFQTGVGVLALAPFVHYDALPATAGQWLDLVALGVVNTGIMYVLLYGAIQKLPTATIGALSFVYPVVAIVVDRFAFGQTLAWSQVGGAALILLAAAGVNLGWRIVPARRVAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y66</accession>
    <name>Q63Y66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189263.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106949.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0322"/>
    <dbReference type="EnsemblBacteria" id="CAH34311">
        <property type="protein sequence ID" value="CAH34311"/>
        <property type="gene ID" value="BPSL0322"/>
    </dbReference>
    <dbReference type="GeneID" id="56594642"/>
    <dbReference type="KEGG" id="bps:BPSL0322"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1364"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGLIFCS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="35894" checksum="B9801E523DD5746F" modified="2004-10-25" version="1">MGTTIRDVAQAANVSIGTVSRALKNQPGLSEATRARIVEIAHRMNYDPTQLRPRIKRLTFLLHRQHNNFATTPFFSHVLHGVEDACRERGIVPSLLTTGPTDDVIRQMRPHAPDAIAVAGFMEPETLEALAATGRPLVLIDIRAPGLRSINVDNAGGAALAMHHLFASGRRRVAFIGGSLAHYSIAQRALGYRRAFFDAGMLFDPSLELSIDTSLGPDAGAANAMRQLLDAGGALPDAVFAYNDAAALAAMRVCVERGVRVPEDIAFVGFDDIPAAAHAAPPLTTLAIDKEALGRQGVELLLADSPAQAELSLPVQLVARASSAGAARAPRTLTSVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YB8</accession>
    <name>Q63YB8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525899.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106897.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0270"/>
    <dbReference type="EnsemblBacteria" id="CAH34258">
        <property type="protein sequence ID" value="CAH34258"/>
        <property type="gene ID" value="BPSL0270"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0270"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1435"/>
    <dbReference type="eggNOG" id="COG1815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHMARND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17150" checksum="07430FAE7752B34F" modified="2004-10-25" version="1">MLDKLDAEFAFGRQALDVRAYRQELLSSNIANADTPGYRARDVDFSSTLARALKQDGAASAGNAAQLPLAQPAGVASGMSMATTSGAHLAGNVKLIPTGGPSDDYGRAQYRIPQQPALDGNTVDLDTERVQFADNAVHYQAGMTVMTQQIKTMIAAITSNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YH6</accession>
    <name>Q63YH6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative lipid A biosynthesis acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523078.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106839.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0211"/>
    <dbReference type="EnsemblBacteria" id="CAH34198">
        <property type="protein sequence ID" value="CAH34198"/>
        <property type="gene ID" value="BPSL0211"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0211"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1506"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWFHRRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="33620" checksum="9B08FAF2501D20DF" modified="2004-10-25" version="1">MLGRLGTRLAVAFLKFLAVLPYGLTARLGDGLGWLLYRIPSRRKRIVHINLQLCFPDWSDARREEIAGRHFRHAIRSYVERSVQWFGSAKKLEKLIQVDSAIDLTDPNLPPTLFLGLHFVGIEAGSIWLNRSLQRRCGSLYQPFSNPTLEAIAKAARGRFDAEMVGRADSARVVLRWLRDRKPVMLGADMDYGLRNSTFVPFFGVPACTLTAVGRLARTGHAQVVPFIGEVLPDYQGYRLKVFKPWENYPTGDDDLDARRMNAFLEEQIPLMPEQYYWVHKRFKTRPPGEPSVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YJ0</accession>
    <name>METXS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homoserine O-succinyltransferase</fullName>
            <shortName evidence="1">HST</shortName>
            <ecNumber evidence="1">2.3.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Homoserine transsuccinylase</fullName>
            <shortName evidence="1">HTS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metXS</name>
        <name type="ordered locus">BPSL0197</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:22008"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="EC" id="2.3.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.46" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198305.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106825.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YJ0"/>
    <dbReference type="SMR" id="Q63YJ0"/>
    <dbReference type="STRING" id="272560.BPSL0197"/>
    <dbReference type="ESTHER" id="burma-metx">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34184">
        <property type="protein sequence ID" value="CAH34184"/>
        <property type="gene ID" value="BPSL0197"/>
    </dbReference>
    <dbReference type="GeneID" id="56594457"/>
    <dbReference type="KEGG" id="bps:BPSL0197"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1522"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRFCVVS"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155709" description="Homoserine O-succinyltransferase">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="1">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <sequence length="381" mass="42018" checksum="286589ACA8F5EFD9" modified="2004-10-25" version="1">MESIGVVAPHTMHFAEPLRLQSGSVLGNYQLVVETYGELNAARSNAVLVCHALNASHHVAGVYADDPRSTGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSIDPATGTPYGARFPVVTVEDWVHAQARVADAFGIERFAAVMGGSLGGMQALAWSLLYPERVAHCIDIASTPKLSAQNIAFNEVARSAILSDPDFHGGDYYAHGVKPRRGLRVARMIGHITYLSDDDMAEKFGRALRRADGALDAYNFNFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFNGDLSAALAHTKAKYLIASFMTDWRFAPARSREIVKALLDNRRSVSYAEIDAPHGHDAFLLDDARYHNLVRAYYERIAEEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YJ3</accession>
    <name>Q63YJ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106822.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0194"/>
    <dbReference type="EnsemblBacteria" id="CAH34181">
        <property type="protein sequence ID" value="CAH34181"/>
        <property type="gene ID" value="BPSL0194"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0194"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.204"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QWEVNLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="7">
        <location>
            <begin position="88"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="314" mass="33827" checksum="2BEE417FC7BA5579" modified="2004-10-25" version="1">MLVADNGAPPVPSAPAVATPAAPAAAPAAGNPQPYALGDQQVRYGNAIVFRSLIPSPLLEQLTDNEYRQTVQDAAQRKRLLPPNNARVKRLRTIVMRLAPYAVKWSERVKGWNWEIEVLRSRSIRAFCLPGGKVLVDSGLLERLRLTDDELGVLFAHEIAHALREHARSSLGEQQAASLGTGATPLPPLFGLSEPLPAPLGVVERFASVRYDPTDETEADVIGGDIAARAGFDPRAAITLWDKLAVATRADKDNGFIHAHPYDTRRRNDLRKRLADLMPLYRKALVKNADARANAAGAGAAAGAKQRGAAAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM5</accession>
    <name>Q63YM5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage-encoded lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009909361.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106790.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0162"/>
    <dbReference type="EnsemblBacteria" id="CAH34149">
        <property type="protein sequence ID" value="CAH34149"/>
        <property type="gene ID" value="BPSL0162"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0162"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1560"/>
    <dbReference type="eggNOG" id="ENOG5033B9B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HQRAACA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020000">
        <property type="entry name" value="Phage_P2_LysB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03495">
        <property type="entry name" value="phage_LysB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="15599" checksum="F697D5886944F3A8" modified="2004-10-25" version="1">MNLSRLMPWLALLALIALVASCQHGRALRAQLDRATDDARRAKLDAQASAAVIERLLADAKAKDAQRAQLARARAGVDATLATYRNELRRLIDENAAVRAWAAGALPDDVVRLHASPALNGADDFAQRMRGGDAVHDAGDGAANQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>P0DMK5</accession>
    <accession>Q63S12</accession>
    <accession>Q9WWX6</accession>
    <name>HLDD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADP-L-glycero-D-manno-heptose-6-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-L-glycero-beta-D-manno-heptose-6-epimerase</fullName>
            <shortName evidence="1">ADP-glyceromanno-heptose 6-epimerase</shortName>
            <shortName evidence="1">ADP-hep 6-epimerase</shortName>
            <shortName evidence="1">AGME</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hldD</name>
        <name type="synonym">gmhD</name>
        <name type="ordered locus">BPSL2509</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose</text>
            <dbReference type="Rhea" id="RHEA:17577"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61506"/>
            <dbReference type="EC" id="5.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
        <text evidence="1">Binds 1 NADP(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homopentamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.20" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004544120.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109105.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0DMK5"/>
    <dbReference type="SMR" id="P0DMK5"/>
    <dbReference type="STRING" id="272560.BPSL2509"/>
    <dbReference type="EnsemblBacteria" id="CAH36516">
        <property type="protein sequence ID" value="CAH36516"/>
        <property type="gene ID" value="BPSL2509"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2509"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2872"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LRDFVYI"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008712">
        <property type="term" value="F:ADP-glyceromanno-heptose 6-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05248">
        <property type="entry name" value="ADP_GME_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01601">
        <property type="entry name" value="Heptose_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011912">
        <property type="entry name" value="Heptose_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02197">
        <property type="entry name" value="heptose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205790" description="ADP-L-glycero-D-manno-heptose-6-epimerase">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01601"/>
        </source>
    </evidence>
    <sequence length="330" mass="37019" checksum="3DBF6A129000E524" modified="2014-07-09" version="1">MTLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYMMDNNFRYSRAVLDACLAQGTQFLYASSAAIYGGSSRFVEAREFEAPLNVYGYSKFLFDQVIRRVMPSAKSQIAGFRYFNVYGPRESHKGRMASVAFHNFNQFRAEGKVKLFGEYNGYGPGEQTRDFVSVEDVAKVNLHFFDHPQKSGIFNLGTGRAQPFNDIATTVVNTLRALEGQPALTLAEQVEQGLVEYVPFPDALRGKYQCFTQADQTTLRAAGYDAPFLTVQEGVDRYVRWLFGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HW0</accession>
    <name>Q63HW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187088.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112312.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2309"/>
    <dbReference type="EnsemblBacteria" id="CAH39795">
        <property type="protein sequence ID" value="CAH39795"/>
        <property type="gene ID" value="BPSS2309"/>
    </dbReference>
    <dbReference type="GeneID" id="56598418"/>
    <dbReference type="KEGG" id="bps:BPSS2309"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5940"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGMGVKD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="191" mass="20138" checksum="7AB5BD20F1817780" modified="2004-10-25" version="1">MTTPSADDRADANPPRASATRVIVRATELADAAAIAQIRNQPLVQHGTLAMPHASADAVAAWLVRLAARRNGGLDLCAEVDGRVVGHGGLELFSGRRAHCALLGIGVHDAYAGRGVGRALMAALVDGADRALGLRRIELTVFADNARAIALYRRFGFVEEGRSRGYAIRGGELADVLHMARLADAPPFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HX4</accession>
    <name>Q63HX4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112298.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2295"/>
    <dbReference type="EnsemblBacteria" id="CAH39781">
        <property type="protein sequence ID" value="CAH39781"/>
        <property type="gene ID" value="BPSS2295"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2295"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6744"/>
    <dbReference type="eggNOG" id="COG3246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QCVRVAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="37416" checksum="143D7670343F6CCD" modified="2004-10-25" version="1">MDKVVITVAPYGPEWMPEDFPEDIPVTMAEQVQKAVDCYNAGATVLHLHVRELDGRGSKRLSKFNELIAGVRAAVPDMIIQVGGSISFAPEDDGQAAKWLSDDTRHMLAELDPKPDQVTVAINTTQMNIMELLYPEYLAGTSLANSALHAAYSEMTVPAGPAWVEEHLRRLQAAGIQPHFQLTGIHALETLERLVRKGTYTGPLNLTWIGIGGGFDGPNPFNFFNFIQRVPDGCTLTAESLLKNVLPFNTMALAMGLHPRCGIEDTIIDQHGERMTSVRQIEQTVRVARELGREIASGKQARDIYRIGVQYRDADETLAANGMAPNRQPGSRRERRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ1</accession>
    <name>Q63HZ1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112281.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2278"/>
    <dbReference type="EnsemblBacteria" id="CAH39764">
        <property type="protein sequence ID" value="CAH39764"/>
        <property type="gene ID" value="BPSS2278"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2278"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5892"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WAPRLGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="552" mass="60191" checksum="6A334268AC4A0AA6" modified="2004-10-25" version="1">MKQQSYDYDYVVVGSGFGGSVSALRLSEKGYRVLVIEQGRRWTPENLPESTWNLSRWQWRPALGLRGFFSMRFFRHVVVLHGNAVGGGSITYANTLLVPPDKVWREGTWAGLEDWERVMPAHYATAKRMLGVVTNRRMDAADFRLKDMAKLIGVEKSFYPTEVGVFFGDDADAPGTRYADPYFGGAGPERTSCIGCGGCMVGCRHGAKNTLDRNYLYLAERLGAQVREQTKVVDVRPLDARADGAAGYAVEAVSLAAGARGAKSRLTCRGVVFAASSLGTQDLLMRLKEKGSLPRLSDALGKRVRTNAESLIGVRFPKSRVDLSKGVAIGSGIYIDEHTHIEATRYPSGSDTMGLLTTVLTRGAPGGLRVLVWLGALAKLVLTRPLSAWRMIDPRGFARETMIFLCMQTLEGHLTMRLKRRWFWPFSKQLATSGAKIPAYIPAANDFAQKAARALGGVPMTSLTEILLNVPMTAHCMGGAAMARDARDGVCDGRSRVFGYRNMYVCDGSVLGANLGVNPSLTITALAEHAMSHVPAAREQRWDSTAETPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I21</accession>
    <name>Q63I21_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112251.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2248"/>
    <dbReference type="EnsemblBacteria" id="CAH39734">
        <property type="protein sequence ID" value="CAH39734"/>
        <property type="gene ID" value="BPSS2248"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2248"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6683"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYHPRYF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="33378" checksum="556364C16B3C1C36" modified="2004-10-25" version="1">MPTREPRMTAIVLTHRRESELARTLAQLAKLPEQPAIVVVDNASNDGTAAMVRRRFPRATLVRAPRNLGAAGRNLGAACARTPYIAFCDDDTWWESGSLTLAAQLFERHPRIGALTARVLVGIERREDPTCALMRASPLEHAPQQPGPTILGLLAGATAFRRGAFCAAGGYHPRLFVGGEETLLALDLTTAGWSLVYAPQLTVVHYPSPVRDARGRASVIARNAVWTAWLRLPAFAALLRTLRAAPRVWREAGGLRGWRRTLAGLPWTLRERRPIPTHVDAMRRVVEAADRLARRQARRQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I58</accession>
    <name>Q63I58_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ordered locus">BPSS2212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536971.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112214.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2212"/>
    <dbReference type="EnsemblBacteria" id="CAH39697">
        <property type="protein sequence ID" value="CAH39697"/>
        <property type="gene ID" value="BPSS2212"/>
    </dbReference>
    <dbReference type="GeneID" id="56531698"/>
    <dbReference type="KEGG" id="bps:BPSS2212"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5801"/>
    <dbReference type="eggNOG" id="COG1273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRYRKVC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="53"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="368" mass="40252" checksum="ED67F0ACD884D7AC" modified="2004-10-25" version="1">MARMIWKGAISFGLVHVPVQLYPATRTVKPSFRLLDKRSLDPVGYRQINKRTGKAVPREDIVRGYEYEKERYVILTDEEIRAANPESTQTVDILTFVDDEAVSFLYLDTPYYLVPDRGGEKVYALLRDALKRSGKIGIALVVMRDRQHLGAVIPVGPLLALDTLRWQDELRPLAEIDAPAADAKKAGVSAREFEMAAKLIDDMSGDWSPDDYHDTFRDDILALVDRKVREGRVEEIAQEDTAPARRTADIVDLTELLKRSLGRAKGPRRAPDGGANERGDSGEGGDSGEGGGRGGGELARELERSVGGTRGGRGGGRKKAEPHAPPRKRAQAAATKRGKQAKPRDGASRASARTAAKKPAAARKRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ4</accession>
    <name>Q63IJ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112078.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2075"/>
    <dbReference type="EnsemblBacteria" id="CAH39556">
        <property type="protein sequence ID" value="CAH39556"/>
        <property type="gene ID" value="BPSS2075"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2075"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHEEHKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="23697" checksum="48D2815DAA75CE7F" modified="2004-10-25" version="1">MPLASRSPGDQMAKSFQRFTLHVQLQHIEPPIWRRIEVEGTESLRKLHHILQAAFGWEDTHLHDFLIDGMTYAMFEVDDVLDFADPGTTADDRKVRLQKVLQPGSRFLYRYDFGDGWDHAIVVERVETVESEPWGAAQVIDGARACPPEDVGGPPGYDAFLSTLSNDPNSEEADHYRNWVGPGFDSELFDLRAANATLLRMASNRWGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IN6</accession>
    <name>Q63IN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539281.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112036.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2033"/>
    <dbReference type="EnsemblBacteria" id="CAH39511">
        <property type="protein sequence ID" value="CAH39511"/>
        <property type="gene ID" value="BPSS2033"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2033"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5561"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMEMIMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="28089" checksum="8B0E3AE397F65F70" modified="2004-10-25" version="1">MTGTTFSTPAPLHVAQADGVRFATLNRPARRNALSDDLVAALDAECERAAGDAAVRALVLRGAGGMFCAGGDFGGFSAMMREPAPAGEPDPIAAANRRFGALLEKLAALPVPTLAVVEGAAAGGGCGLAAACDRVLIASDAQLSLPETSLGLPPAQIAPFIVARAGAARGCWLMLTAGRLSAADALDAGLADEIAGADGIDALLRRALARVLACEPAALRATKRIVADALRRERGAALDAASGEFAAALRSGAVAEGLAALSGKRAPRWASDAPVPPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IP2</accession>
    <name>Q63IP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112030.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2027"/>
    <dbReference type="EnsemblBacteria" id="CAH39505">
        <property type="protein sequence ID" value="CAH39505"/>
        <property type="gene ID" value="BPSS2027"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2027"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6416"/>
    <dbReference type="eggNOG" id="ENOG5033I0I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YFHSAPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267228" evidence="1">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="124" mass="13294" checksum="F674E1F87F646F28" modified="2004-10-25" version="1">MNHSTITWAAVLALCAGFAVTNAHARDSAECRRLSDATGGADDNFRPPLTATVTGAGRAYFHSAPASACIARRVFVVPGDTVTVYKPYRHWYQVMYVNGRTGEDVEGWIEAGRLRLGGHLGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IR8</accession>
    <name>Q63IR8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112004.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1998"/>
    <dbReference type="EnsemblBacteria" id="CAH39476">
        <property type="protein sequence ID" value="CAH39476"/>
        <property type="gene ID" value="BPSS1998"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1998"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5511"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHRAPIQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266903" evidence="2">
        <location>
            <begin position="17"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="954" mass="101111" checksum="BCBD77DE1469077C" modified="2004-10-25" version="1">MYRRFLLVGMTALALAACNSDSVDTPALGDTRTTLLATGQLISPAAAPGAAFVPLNPGLADAPGYIAGQPVSEALSPDRKTLLVLTSGYNNVLDANGKMIKPDSNEYVFVFDVSGGAPVRKQVLQVSDTYVGIAFAPDGQHFYVTGGGDDNLHRFAFSQGAWGEVGAPIALNHKAGNGIGSTPLATGVDVTADGKRAVVANRYNDSITLVDLGAGAVLAERDLRPGKSGGASGAPGGEYPNAVRIVGNKTAYVSSERDREIVVVDLSTNAPQVVTRIPVKGNPNKMVLNAAQSRLYVASDNADLVSVIDTAANKVVSTVSTVAPAGLVTEMQYRGASPNGLALSADERTLYVTNRGTNDVAVISLAGASPAVTGLIPTGWYPSDVALGATNAMYVVYTKNMPGPNPGNCKDSGRTVPCPVKNTPVKLVENQYIEQLSKGGLMWMPAPGSKTLDLLTTQVANNNSFNAALTPNDIATMAALRKKIKHVIYIVKENRTYDQILGDIGRGNSDPSLAEFPDATTPSMHALAKTFVTLDNFYDSGDVSGDGWPWSTGARESDAGAKMLPVNYANSPARAGARGGSYDWEGANRNVNVGLTGAQRAAANPSLPSDPDLLPGNADVSAPDGPSDAVQQGYIWNAALRAGLTVRNYGFFADLARYSGPGAIAPDRTPFVDHAVQTYATSPALVDRTDPYFRGYDNAYPDFYRELEWEREFNGFVANGQMPSLTLLRLPHDHTGSYSSALDGVNTPEIQMADNDYAVGRVAQAVANSPYAADTLIFVVEDDAQDGPDHVDAHRSTAFVIGPYVKQNAVVSTHYTTVNMIRTITEVLGLDHLGLFDATQGPMTDVFDLNQSKWSFKAVASGLLANTQLPVPSGDIKTAAFKPTHGMRYWALATRGMDFSVEDRLDAVAYNKLLWKGLMSGRAYPVRVGERAAPHRRDDDDDVKVSQARSAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IZ4</accession>
    <name>Q63IZ4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">AMP nucleosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.2.4" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111928.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1922"/>
    <dbReference type="EnsemblBacteria" id="CAH39400">
        <property type="protein sequence ID" value="CAH39400"/>
        <property type="gene ID" value="BPSS1922"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1922"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5405"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IQTGRME"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="35094" checksum="E5DC12838852EC54" modified="2004-10-25" version="1">MNPPPPPRAKRRRTRTASAPAPGMRPTPRRTRTAPKRRAPLSSTVERLVSSPTYRQADEDLAFLQRPEMCGVRLQLDYWKTEETLQRFGICDTVVVYGSTRIASPAVARARLADAQHRLAERPNDPERRHAVSVAVRLLERSHYYGVARDLGRLVGETGRSPHPRRLTIITGGGPGIMEAANRGAHERGAPSIGLNITLPREQFPNPYVTPELCFRFHYFAIRKLHLLERAKAAVFFPGGYGTCDELFEVLTLLQTRKIAPLPVVLVGRAFWRSAVDFGFLVDEGMIDPCDAALFRFCETADEIWAAIGGPHGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J12</accession>
    <name>Q63J12_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoate 1,2-dioxygenase beta subunit</fullName>
            <ecNumber evidence="2">1.14.12.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">benB</name>
        <name evidence="2" type="ordered locus">BPSS1904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.10" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190416.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111910.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63J12"/>
    <dbReference type="STRING" id="272560.BPSS1904"/>
    <dbReference type="EnsemblBacteria" id="CAH39382">
        <property type="protein sequence ID" value="CAH39382"/>
        <property type="gene ID" value="BPSS1904"/>
    </dbReference>
    <dbReference type="GeneID" id="56598316"/>
    <dbReference type="KEGG" id="bps:BPSS1904"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5373"/>
    <dbReference type="eggNOG" id="COG5517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VTYWMPA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018623">
        <property type="term" value="F:benzoate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017641">
        <property type="entry name" value="Benzo_1-2-diOase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03232">
        <property type="entry name" value="benzo_1_2_benB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="19131" checksum="3254AF90FC4398EA" modified="2004-10-25" version="1">MKTIDLADIQAFLYRESRLLDDKAWDAWLDCYRADAVFWMPSWDDADALVTDPQREISLIYYPNRQGLEDRVFRIKTERSSATVPDTRTSHNIANVERESADGDVHTVRFNWHTLSYRYKTVSSYFGMSRYAIDFSGDAPKIVSKYVVLKNDYINQLIDIYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J28</accession>
    <name>Q63J28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative aromatic oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111894.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1888"/>
    <dbReference type="EnsemblBacteria" id="CAH39366">
        <property type="protein sequence ID" value="CAH39366"/>
        <property type="gene ID" value="BPSS1888"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1888"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6234"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRNEDHG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08880">
        <property type="entry name" value="RHO_alpha_C_ahdA1c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043264">
        <property type="entry name" value="AhdA1c-like_alpha_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="46"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="418" mass="47427" checksum="47B19A940E88B995" modified="2004-10-25" version="1">MALIDRADSSDVRFPRDDGSRVPYKVFSSQAVYEREQERIFRGPTWNFVALEAEIPKPGDFKSTFVGDTPVVVTRGEDGALAAWVNRCAHRGAQVCRKARGNASSHTCVYHQWSFDSRGDLLGVPFRRGQKGMAGMPADFDPKNHGLRKLRVDSYKGLVFATFSDEVAPLPDYLGAQMRPWIDRIFHKPIEYLGCTRQFSKSNWKLYFENVKDPYHASMLHLFHTTFNIFRVGMKARSIPDATHGLHSIITMTKTQDDADTASAYKQQNIRSFDEGFSLEDDSILGLVSEYDEDTTNHIQPIFPQLVIQQIHNTLVARQLLPKGPKNFELIFHFFGYADDTPELRDLRIKQANLVGPAGYISMEDTEATELVQRGTVRDANAASVIEMSRGNPDQQDTAITESLIRRFWVGYQQLMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J37</accession>
    <name>Q63J37_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525042.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111885.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1879"/>
    <dbReference type="EnsemblBacteria" id="CAH39357">
        <property type="protein sequence ID" value="CAH39357"/>
        <property type="gene ID" value="BPSS1879"/>
    </dbReference>
    <dbReference type="GeneID" id="56529702"/>
    <dbReference type="KEGG" id="bps:BPSS1879"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5344"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DIGSHYI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="187"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="378"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="546" mass="60652" checksum="729BBA954B968206" modified="2004-10-25" version="1">MKASDLFVKALEAEGVQYVFGIPGEENLDLLESLRRSRIKLVLTRHEQAAGFMAATYGRLTGKTGVCLATLGPGATNFVTAAAYAQLGGMPMLMITGQKPIKSSKQGHFQIVDVVGMMQPLTKLTRQIVSIGNIPSAVREAFRRAEEERPGATHLELPEDIAHEEGDGKPIPASYSRRPIAEEKALARAVDAIQAARHPLLMIGAGGNRKTTCRMLKEFVDTTGIPFFTTQMGKGVIDETHPLWLGNATLSDGDFVHRAIEHADCIINVGHDVIEKPPFFMRADDKTVIHVNFLGAQVDPVYFPQIEVVGDIANAVWQMKEKLARQPHWDFSRFMLIKAHFDAHLKKGQDDPRFPMYPVRIVNDLYRSLPEDGIVCLDNGMYKIWFARYWRAHEPNSLLLDNALASMGAGLPSAIATKIVHPQRKVIAVCGDGGFMMNSQELETAVRLKLDLVVMILRDDAFGMIRWKQENMNFPDYAMTLANPDFVAYAQSYGAHGHRIASADALEPLVRECFASPGVHLIDVPIDYSDNERVLNREIKRLSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J38</accession>
    <name>Q63J38_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525043.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111884.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1878"/>
    <dbReference type="EnsemblBacteria" id="CAH39356">
        <property type="protein sequence ID" value="CAH39356"/>
        <property type="gene ID" value="BPSS1878"/>
    </dbReference>
    <dbReference type="GeneID" id="56529703"/>
    <dbReference type="KEGG" id="bps:BPSS1878"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5343"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMVMRET"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="477" mass="51771" checksum="4FCAB4AE0D8532CB" modified="2004-10-25" version="1">MLKETYPYYLANEAVYANTGLEVTDKYSGKVATRVALADARAIDAAIAAAVAAQRPLRALPAFRRQAILEHCVARFRERFDELAEALCIEAGKPINDSKGEVTRLIDTFRVAAEESVRIEGGLVNLEISPRAQGYSGYYRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPIGALIIGEVLAQTDLPKGAFSILPAHRDGADLFTTDERFKLLSFTGSPAVGWELKKRAGKKKVVLELGGNAAAIVDADQRDRLDYVVDRLAFGAYYQSGQSCIGVQRIIAHADLYDALREKLIAKTRSLKMGDPKDPATFVGPMISEAEARRLAGWMDAAVAAGARIIAGGNVDGAMFEATLLEGVGRDQDLYRKEAFGPVALLERFADFDDALARVNDSDFGLQAGVFTDSLSHAQRAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTELRLMVVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J55</accession>
    <name>Q63J55_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540175.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111867.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1863"/>
    <dbReference type="EnsemblBacteria" id="CAH39339">
        <property type="protein sequence ID" value="CAH39339"/>
        <property type="gene ID" value="BPSS1863"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1863"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5319"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MITARNG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="232" mass="24584" checksum="43B3F37FAFE89676" modified="2004-10-25" version="1">MTIEVGLLLFPQVQQLDLTGPHDVFASLPGVTVRLVWKTREPVASSSGLVLAPNATFDDCPPLDVICVPGGIGVADLMEDADTLAFLRRHAAHARYVSSVCTGALVLGAAGLLRGRRATTHWAFHSLLAPFGATPVRERVVRDGNLVTGGGVTAGIDFALTLAAELVGEDDAQAVQLQLEYAPAPPFAAGDPDTAPARIVERMRERSKPVLARREQVVARAVAALERRRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J58</accession>
    <name>Q63J58_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111864.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1860"/>
    <dbReference type="EnsemblBacteria" id="CAH39336">
        <property type="protein sequence ID" value="CAH39336"/>
        <property type="gene ID" value="BPSS1860"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1860"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5313"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MKFNCIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021862">
        <property type="entry name" value="DUF3472"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11958">
        <property type="entry name" value="DUF3472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266079" evidence="1">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="395" mass="41551" checksum="5FBFF044E7C7D277" modified="2004-10-25" version="1">MKFNCIAATILAAVAADATAAGACLNGSTIASTTRAPLVARQGSVFSSTLYDPAITSNNRTHNPVMLTVKVTNNGRPVAGCDVAWQPRGAGGASGWLFPASASTDANGIASAWWVAGSGAAQTAVASIRRFDGTTQGVAIGGSAQPHATRANSIHLNYEPASDWTAFRVDVTPEALAPTTYWEAIGWPGAYTGIQSIDGKQDGLVLFSVWDVNGKSPQIIAKGPGVDCTQFGGEGTGYKCAKRHAPVAGRTYRFMASIAPVAGQNQTDYSVWFTDTSTNARELIATLRYQKAVQSANYANSFVEDWATQGASCLGATQRAGQYGNVWALDRASAQWRTVKRASTSAVYTPDHNEVCSNYQFSVVNGRFRMSTGGHAVGQPLNLPNGPKSFPLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J61</accession>
    <name>Q63J61_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS1857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205692.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111861.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1857"/>
    <dbReference type="EnsemblBacteria" id="CAH39333">
        <property type="protein sequence ID" value="CAH39333"/>
        <property type="gene ID" value="BPSS1857"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1857"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5310"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEKDCIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="249"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="44399" checksum="ABDDACA97126DAF1" modified="2004-10-25" version="1">MDFSPSARCRELSERIAAFMRDEIAPVEARYAEQLTGDVDWRRWRQPDVMETLKAKARAAGLWNLFLPEAEHGGAGLSNAEYAPLAELMGHSFIAPEAFNCNAPDTGNMEVLARYGSPEQRRRWLEPLLAGEIRSAFCMTEPEVASSDATNMRATAKLEGDEIVLNGRKWWSTGIGHPLARVVIFMGLTDPQAEPHRRHTMVLCPLDAPGVRIERMLPVFNAYDEPSGHGEVSFTNVRLPASNVILGPGRGFEIAQGRLGPGRIHHCMRALGAAEKALTLLCARATARTAFGKPLVKLGGNGDVVANLRMAIEQARLLTLKAAWTIDTQGVKAALSLISQIKVVVPAVAQQAADAAIQIHGGAGLSNDFPLAALYAYARVLRIADGPDEVHRAVVAKLEVKRQLAAAEAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JF5</accession>
    <name>GCH4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase FolE2</fullName>
            <ecNumber evidence="1">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">folE2</name>
        <name type="ordered locus">BPSS1761</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts GTP to 7,8-dihydroneopterin triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195713.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111767.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JF5"/>
    <dbReference type="SMR" id="Q63JF5"/>
    <dbReference type="STRING" id="272560.BPSS1761"/>
    <dbReference type="EnsemblBacteria" id="CAH39236">
        <property type="protein sequence ID" value="CAH39236"/>
        <property type="gene ID" value="BPSS1761"/>
    </dbReference>
    <dbReference type="GeneID" id="56598187"/>
    <dbReference type="KEGG" id="bps:BPSS1761"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5192"/>
    <dbReference type="eggNOG" id="COG1469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PCSQGMS"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_B">
        <property type="entry name" value="GTP_cyclohydrol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022838">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000147707" description="GTP cyclohydrolase FolE2">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="site" description="May be catalytically important" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <sequence length="269" mass="30188" checksum="832F04704D584F29" modified="2004-10-25" version="1">MNLMNPEFAMPDVQSTVDTRQMPIQRVGVRAVRHPLTVRTAEGETQATVGTWNLDVHLPADQKGTHMSRFVALLEERGGPLTADAFRTMLATMLEKLEARAGRIEVSFPYFVNKTAPVSGVRSLLDYEVTLTGDVRDGLTRVFAKVLVPVTSLCPCSKKISQYGAHNQRSHVTIDAELAADVPVEDLIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVARRLDADERIVAYVLEAENFESIHNHSAYALIERDKRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH3</accession>
    <name>Q63JH3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190837.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111749.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1743"/>
    <dbReference type="EnsemblBacteria" id="CAH39218">
        <property type="protein sequence ID" value="CAH39218"/>
        <property type="gene ID" value="BPSS1743"/>
    </dbReference>
    <dbReference type="GeneID" id="56598097"/>
    <dbReference type="KEGG" id="bps:BPSS1743"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5170"/>
    <dbReference type="eggNOG" id="ENOG502ZM7T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PDAIVCG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021333">
        <property type="entry name" value="DUF2946"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11162">
        <property type="entry name" value="DUF2946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266322" evidence="2">
        <location>
            <begin position="30"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="131" mass="13271" checksum="34BBE0097251878F" modified="2004-10-25" version="1">MPNRFRKLTAWLGMLAIALAIVAPLVSQASARSAAPSSGAVICGDEHRAQPAEAGIAHDGPVHDGVAHHALHLDACGYCAFFAHSPAIGAAAPSLFAIHVAAVAPPIPSGAAAPSLERHTHAYPRAPPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JY1</accession>
    <name>Q63JY1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hipB</name>
        <name evidence="3" type="ordered locus">BPSS1583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539423.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111591.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1583"/>
    <dbReference type="EnsemblBacteria" id="CAH39058">
        <property type="protein sequence ID" value="CAH39058"/>
        <property type="gene ID" value="BPSS1583"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1583"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4960"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ISVRQLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="134" mass="14180" checksum="91833F510017DD01" modified="2004-10-25" version="1">MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAAPAGNDKGEVAKTAAGARRAAPPASAPASAPAPGAAGRAPRPARKRAAPKKREDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JY3</accession>
    <name>Q63JY3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic di-GMP-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cellulose synthase regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bcsB</name>
        <name evidence="8" type="ordered locus">BPSS1582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; bacterial cellulose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Tightly associated with the cellulose synthase catalytic subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AcsB/BcsB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205645.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111589.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1582"/>
    <dbReference type="EnsemblBacteria" id="CAH39056">
        <property type="protein sequence ID" value="CAH39056"/>
        <property type="gene ID" value="BPSS1582"/>
    </dbReference>
    <dbReference type="GeneID" id="56530006"/>
    <dbReference type="KEGG" id="bps:BPSS1582"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5857"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRHRTDC"/>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003920">
        <property type="entry name" value="Cell_synth_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018513">
        <property type="entry name" value="Cell_synthase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39083">
        <property type="entry name" value="PTHR39083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03170">
        <property type="entry name" value="BcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01440">
        <property type="entry name" value="CELLSNTHASEB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015217815" description="Cyclic di-GMP-binding protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="798" mass="85033" checksum="F4C2887B61B14DFE" modified="2004-10-25" version="1">MKPIATFARAFAMACALLCPIASWAALQSAPRPASQPALQPASRPTPAPALQPPRARPRAPRSASLAAGASAPLPASAPLVMPLAAPKPSGLAGAAIHVPFATLGAYEPLRLRGSDTARTVNVGVRLDRMVTAARLRLTYTYSPSLVFPVSHLKVSINGEAVATLPFDSEHAGRAVTQEIPLDARYFTDFNQIELRLIAHYTLDHCEDPEHSALWADVSPTSELIFDEASVRLPNDLALLPAPFFDRRDNSRLRLPFVLPATPDDATLRSAGVLASWFGALADYRQARFPVSSALPANDHAVVVGTAARLPASLALPPIDGPMLVVTDNPAAPDKKLLVVTGRSAADVDAATNALVLGNAALSGPWARVSRIDIGAPRKPYDAPRWVPVDRPVALRELVDSPADLQVRGSAPDPIRLNLRVPADLHSWGGSGVPLALHYRYTAPTVRSDSMLAVEINDQLVQSYRLSPRSQDARGRMQLPLLSGADSRATNDVDIPAFRVGSANQLQLRFTLDSEKTGLCTAVASEPQRAAIDPDSTIDFSRFIHYAMLPNLAYFANSGFPFTRYADLSQTAVVLPPRPSPAEQEAYLTMLGHMGQWTGFPALRVRLARAADAPAIADKDLLVIDGAPPYAQLANWRDALPVAIGEATAGGGFSRAAFSVKERWHDDARSPAGGARFEQSGTLAALFGFERPGGDGRSVVALTATDARHLGDLLDVFEKPGLVAQLQGDVALVRAGAVESLRVGEPYLVGYVPWYARVWTAVARHPMLLGLLGAAAGLLLALGAFGALQRIAARRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JZ0</accession>
    <name>Q63JZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530604.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111582.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1576"/>
    <dbReference type="EnsemblBacteria" id="CAH39049">
        <property type="protein sequence ID" value="CAH39049"/>
        <property type="gene ID" value="BPSS1576"/>
    </dbReference>
    <dbReference type="GeneID" id="56530013"/>
    <dbReference type="KEGG" id="bps:BPSS1576"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4950"/>
    <dbReference type="eggNOG" id="COG2194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDKMQMS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017744">
        <property type="entry name" value="BcsG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11658">
        <property type="entry name" value="CBP_BcsG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03368">
        <property type="entry name" value="cellulose_yhjU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="518" mass="55655" checksum="8425E41D50F22028" modified="2004-10-25" version="1">MTFWNLYFVLKLYLFAAGHLKPLWIANLGFALALALSAPARRRSVQLLRHALALALAVPLMYREADVPPLARLVETLGGLRAFSAGYWMELVPRFVPPMLALAALGVVIGYLIVNRWLRVATFVLLALIALPVWQAGSAALARLDAAAAAVPGPAGTGRAVQPQDHNAALAAFRSQESQRQVTFGRPSADPATQFDVIVLHVCSLSWDDLDVARLRNHPLLGHFDYLFTNFSTAASYSGPAAIRVLRASCGQEAHADLYKPAPAQCHLFGQLAAAGFAPQTLLNHDGHFDNFLQLIRENIGVPNAPMIPNADAPVAMHAFDGSAIKDDYATLANWYAKRGASPGPVALYYNTISLHDGNQLTGGRMSSLDSYPLRARKLLDDFDRFADLIAASGRRAVIVFVPEHGAALRGDAKQVAGLREIPTPRIVHGPVGVRLVGFKGDHGATTVIDAPASFLALAQLLANLVSSSPFKPGVTLSQYAADLPQTRMIGENEGTVTMTTPTGYAVKTPDGVWIDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KH6</accession>
    <name>Q63KH6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940693.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111396.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1384"/>
    <dbReference type="EnsemblBacteria" id="CAH38857">
        <property type="protein sequence ID" value="CAH38857"/>
        <property type="gene ID" value="BPSS1384"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1384"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4705"/>
    <dbReference type="eggNOG" id="ENOG5031VIX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANEGVGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="509" mass="52501" checksum="38BAB75CA61F1ADA" modified="2004-10-25" version="1">MKTNSITGSSRVGLRDNDASASESLLGNNEHQPTKLNRSEMFSSLRDLSKPCGDGREIKVQFKAKSAPELNADSTADVHLPSTRNAEHVPEGRLENTGSLQEGGSADRVEPEASNAPSRTSHGVEPGGEGERVSRASANEGVGHAALSMLKNGMRNVGAVAARNLVSVLPQTAAREAVRAYLTPALAAAPAGVATAAGAVAAAAPIVQNFVGLVRDIQNGTSSRTRVISRTAMMVTTGGFLAASAATGTLAAAAPALVAANAIYTPLRDLVQYNVQLKDNNQQPANMKRVLGSAAAYGVNQGLVNEAMDRVAGAARGRFEAETSVQSGVTTDGTPQVSTAALETHTNPSASLGVDVPSSGYVLARSAGFAAANFAGETLDELTLRGATALQQGNLSNLQISVGWRPQDERTWSAVADQAFTTNAARSTLFANAYMGAYAIPSPPGAASDAVVGSILGGLYTAFIKVHDTPQRALPDEERGIDELASTGRGRENAAVLTIEDETRSTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KJ9</accession>
    <name>Q63KJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111373.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1363"/>
    <dbReference type="EnsemblBacteria" id="CAH38834">
        <property type="protein sequence ID" value="CAH38834"/>
        <property type="gene ID" value="BPSS1363"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1363"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5585"/>
    <dbReference type="eggNOG" id="ENOG50333YQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WANDSTK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266944" evidence="1">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="14873" checksum="532610BF64B35F17" modified="2004-10-25" version="1">MEMKTIAIVSALAAGLCFSISSFAQAPASAPLGTTGLCKDGSFYSGASKKGACSGHKGLKTWYGASKAAAATAPAAAASAPAAASGASSPAAATKGTAPAGAPGQVWVNTDTKVYHCATDKYYGKTKHGEYMSEAAAKAKGFRASHGKTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ7</accession>
    <name>Q63KQ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940608.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111314.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1305"/>
    <dbReference type="EnsemblBacteria" id="CAH38775">
        <property type="protein sequence ID" value="CAH38775"/>
        <property type="gene ID" value="BPSS1305"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1305"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4594"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GLQLGYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="306" mass="33293" checksum="D7912C53024D32DA" modified="2004-10-25" version="1">MLNFLVKRLFGLLPTLACVAVLVFLFVHLLPGDPARLAAGPEADDATVALVRADLGLDKPLPAQFASFFARIAHGDFGVSTRSKRPVATEIGERFMPTLTLTVVSMAWATLFGMAIGIASAVWRNRWPDRIGMTLAVSGISFPAFALGMLLMEVFSVKLGWLPVVPDGSWKSYVPPSVTLGAAVAAVMARFTRASFVEVLNEDFVRTARAKGVREPMVVLKHCLRNAMIPVVTMMGLQFGFLLGGSIVVEAVFNWPGLGRLLVDAVTMRDYPVIQAIVLLFSLEFILINLSVDVLYAVINPTIRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KV7</accession>
    <name>Q63KV7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CoA transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539552.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111264.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38724">
        <property type="protein sequence ID" value="CAH38724"/>
        <property type="gene ID" value="BPSS1257"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1257"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4520"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFWRTAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="472" mass="50346" checksum="7D39446551AD26A7" modified="2004-10-25" version="1">MFDLAASSHTEPSGHARAAAYLRDIWQAANGDPEWLRTLAFGGAGVLPSAFPVTDFASAAIGAASVALAEFVHRATGRLPGVRVDRRYASIWFGTSLRPRGWNMPPLWDAIAGDYRTADGWIRLHTNAPHHRAAALAVLGVPPERHAVARAVGQWRGDALESAVVEHGGCAAVMRTEDEWARHPQGRAVRAEPLMIHDDVSIDGPRPAWPMSAERPLRGVRVLDLTRILAGPVATRFLAGFGAQVLRIDPIGWDEPGTVPEVVLGKRCARANLACADGRALLRRLIGEADVVVHGYRPGALDRLGFDADERRRINPGLVDVSLDAYGWSGPWRGRRGFDSLVQTSAGIAAAGMREAGADRPVPLPVQALDHGTGYLLAAAAIRGLVRRLATGAGTSTRASLARTAVLLTSGGLQEAGRQPIAPETAGDLDAWIEDTSWGPAQRVRAPVTIECAPVQWPHPARALGTSPAEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LG5</accession>
    <name>Q63LG5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSS1048a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111056.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1048a"/>
    <dbReference type="EnsemblBacteria" id="CAH38511">
        <property type="protein sequence ID" value="CAH38511"/>
        <property type="gene ID" value="BPSS1048a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1048a"/>
    <dbReference type="eggNOG" id="ENOG5030XCT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AHIYSNP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="61" mass="6937" checksum="311DEAC7C901E2FB" modified="2004-10-25" version="1">MAHIYSNPNQQEAEAIAIRRMIRASNAEQMARRRASDAADVDRPRATLKRIGRVYSIVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LH0</accession>
    <name>Q63LH0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528293.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111051.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38506">
        <property type="protein sequence ID" value="CAH38506"/>
        <property type="gene ID" value="BPSS1045"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1045"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4237"/>
    <dbReference type="eggNOG" id="COG1839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="17366" checksum="B4A423F83C2116CA" modified="2004-10-25" version="1">MLQLLSVAIDKPDTANFILGQTHFIKSVEDIHEALVGAVPGIRFGLAFCEASGKRLVRHSGTGAALTELACRNALAIGAGHCFLVFLGDGFYPLNVLNAIKAVPEVCRIFCATANPTEVVVAQSEQGRSILGVVDGFSPLGIETDEDVRWRKDLLRNIGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LP1</accession>
    <name>Q63LP1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184760.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110980.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0972"/>
    <dbReference type="EnsemblBacteria" id="CAH38434">
        <property type="protein sequence ID" value="CAH38434"/>
        <property type="gene ID" value="BPSS0972"/>
    </dbReference>
    <dbReference type="GeneID" id="56597338"/>
    <dbReference type="KEGG" id="bps:BPSS0972"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7289"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRFVERG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266971" evidence="1">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="247" mass="27064" checksum="CE344F45E8FC6589" modified="2004-10-25" version="1">MKRMLPLAAASALFAPAGAHADHPFTSDDTNTQGDGNWQYELNVERTSKQPDIGRQQLWNTTLTRGFGERVDLYVQAPYTHVQTRSDEDGSGLGDLEIGAKWRVLERGPLSIALKPRFTMPTGDDARGLGNGRASAGAMLLAQYDVARLQVLVNAGLMYQPNRQGNLASIWQACGAIVYRATDKLRLGVDIGVSRNPERGAGAHPAYVIAGAIYTPRDWLDVDLGYRRGLNDQIYDHALMAGLTVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M34</accession>
    <name>Q63M34_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase class-V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004206548.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110837.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0826"/>
    <dbReference type="EnsemblBacteria" id="CAH38288">
        <property type="protein sequence ID" value="CAH38288"/>
        <property type="gene ID" value="BPSS0826"/>
    </dbReference>
    <dbReference type="GeneID" id="56597149"/>
    <dbReference type="KEGG" id="bps:BPSS0826"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7097"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGNCHKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="46"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="385" mass="43357" checksum="47601BF1EAAA755A" modified="2004-10-25" version="1">MTAPLKSLFLLDPSVTYLNHGAYGATPRPVFERHVQWQYELEREPVDFLSRRFAERMAQARAILAEYVDTERDNLVYVSNGTTGVNIVARSLPLGPGDELLTTDHEHGGIERLWRFTAQKRGFEIVRHKVSLPVTTHARFVEDFWRDVTPRTRAILISQLTSPTALVFPVAAICARARARGILTIVDGSHVPGQLPLSLREMDPDFYVGILHKWVCAPKGSAFLYARPDVQPLVEPLVVSWGWEPKNPGPSKFVEYHEWQGSRDISAFLSVPSAIAFQREHDWDGVRKRCIALASDAQREVAALTREPLYHPPGAHEWHGQMVCAQLPPQTDDIALLARLRNECGIDVSVDRFGGRPRIRVSIQGYNGPDDVDRLLGSLKQLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA0</accession>
    <name>Q63MA0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528031.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110771.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0760"/>
    <dbReference type="EnsemblBacteria" id="CAH38220">
        <property type="protein sequence ID" value="CAH38220"/>
        <property type="gene ID" value="BPSS0760"/>
    </dbReference>
    <dbReference type="GeneID" id="56530789"/>
    <dbReference type="KEGG" id="bps:BPSS0760"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7002"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NEGIAEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="154"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="341"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="45422" checksum="8B1ED1337DADAA0B" modified="2004-10-25" version="1">MSLTISEILQLPGLEELQLRAGERSVQRPVRWYYVAENEGIADWVMGGELVFVTGINHPRDEANLLQLIREGAKSRIAGMVILTGEAFIRRIPDSVVALAEQLEIVLIEQPYLLKMVIVTQLIGTALARHENTLRSQRDIVNQLLTGDYPSIDIAAHRARNLQLALDRPRRVVALRLAGVPALFEGRDPAAAEALLQDARQTVQRGLDDWLRDEDGALPVVEQGELFVLLLPCDDPRFRKQKLALGALRDALNRQTGPLALFVGISSTVGAARHYCRGLAEARQALGVAEGMRAGQGLCDYSELGVLKLLAAIPDPTLIDGFVKETLGNLLDSNRKHPTMLIETLEALLQENGNAIKAAEQLSIHRNTLNHRLRRIETQSGQSLADPYFRLNASVALLAWRMSDTQRQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MB2</accession>
    <name>Q63MB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194998.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110759.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0748"/>
    <dbReference type="EnsemblBacteria" id="CAH38208">
        <property type="protein sequence ID" value="CAH38208"/>
        <property type="gene ID" value="BPSS0748"/>
    </dbReference>
    <dbReference type="GeneID" id="56530802"/>
    <dbReference type="KEGG" id="bps:BPSS0748"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6985"/>
    <dbReference type="eggNOG" id="COG4315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWHIAKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014558">
        <property type="entry name" value="UCP029720"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029720">
        <property type="entry name" value="UCP029720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266434" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="123" mass="12851" checksum="F0298BA0F343FC00" modified="2004-10-25" version="1">MRTADVACALAVGFASAAALADAPAMPSGGMLVAANGMTLYTFDKDAPNAGKSLCNGPCAANWPPYKASATDRPAGGYTIIKRDDGTLQWAYQGKPLYFFAKDAAKGDKKGDGFKDVWHAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MD8</accession>
    <name>Q63MD8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family C56 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195593.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110733.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0719"/>
    <dbReference type="EnsemblBacteria" id="CAH38179">
        <property type="protein sequence ID" value="CAH38179"/>
        <property type="gene ID" value="BPSS0719"/>
    </dbReference>
    <dbReference type="GeneID" id="56597604"/>
    <dbReference type="KEGG" id="bps:BPSS0719"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6944"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GEKTGFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="226" mass="23890" checksum="67A22208879C9F0C" modified="2004-10-25" version="1">MKILVVLTSHDELGTTGKKTGFWLEELAAPYYALKDAGAELTLASPRGGLPPVDPKSDDPASQTDATRRFAKDAEAQAALASTRKLADVSIDDYDAVFYPGGHGPLWDLAEDRHSIALIERAIATNKPVAAVCHAPGVLRNVKDPSGASFVKGLNVTGFSNSEEAAVELTEVVPFLVEDMLKTNGGNYSRAADWAPHVVVDGLLVTGQNPASSEPVAEALLNLLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ME9</accession>
    <name>Q63ME9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543523.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110722.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0708"/>
    <dbReference type="EnsemblBacteria" id="CAH38168">
        <property type="protein sequence ID" value="CAH38168"/>
        <property type="gene ID" value="BPSS0708"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0708"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6925"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AWDVSVS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266589" evidence="7">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="10"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="41666" checksum="38F93C3D9E15FD84" modified="2004-10-25" version="1">MKKRTAVAMTAAGLAAVATAHAQSSVTLYGIVDNGIAYQSSSTSLGSTTGGRSAVKMSTGVWAGSRFGLKGSEDLGGGSKAIFQLESGFSTANGTSQFAGGIFTRQAWVGLTNPTYGTLTAGRQYTAYYTLLSPYSPTTWLTGYFGAHPGDIDSLDTSYRTNNSLVYLSPKFYGFTFGGSYAFGGQPGSVNAGSTWSAGIQYMNGPLGIAAAFQRVNNSTSGGGDWGANSTTSNGGAQTAVSAINNGYKTAQAQQRVAVTAGYQFSSAWDISVSYSNVQYIPGVNSTFRNTAIFNTAGAVLHFKPSAQWDFAGGYAYTRATQSNGITSAAQYHQFTLSQYYSLSKRTGLYAVEAYQRANGKTLAGGKIIDATASIGDGFNTSPSSSRSQVGVGVGLIHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MH4</accession>
    <name>Q63MH4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527954.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110697.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0684"/>
    <dbReference type="EnsemblBacteria" id="CAH38143">
        <property type="protein sequence ID" value="CAH38143"/>
        <property type="gene ID" value="BPSS0684"/>
    </dbReference>
    <dbReference type="GeneID" id="56530866"/>
    <dbReference type="KEGG" id="bps:BPSS0684"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6897"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FETRFTD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023922">
        <property type="entry name" value="S04_starv_induced_SfnB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04022">
        <property type="entry name" value="sulfur_SfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="2">
        <location>
            <begin position="31"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="3">
        <location>
            <begin position="253"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="412" mass="44740" checksum="59EB722CE927C3BF" modified="2004-10-25" version="1">MSAIYETAVQPARGATARDAHLIASDAEAIDAARALAARLAEGAAERDRERRLPYEEIDWFSQSGLWAITVPKAYGGAGVSHVTLTEVVKIVAAADPSLGQLPQNHFGLVDVIALTGTDEQKRLFFGEILKGKRFGNGFSEKGTKNVLDLKTKVIRDGDGYRVDGTKFYSTGALFAHYVPVLGIDDARRGWLAYVPKGTPGLAVIDDWSGFGQRTTASGTVRLDNVRVPASHVFAAHRVSDQPTLNGPLSQILQAAIDAGIAHAALDDTLRFVRERSRPWIDSGVERAADDPLTIRETGRLVIRLHAADALLERAARTLDALAAQSELSEDDVARASVAVGEAKVLTTEIALLASEKLFELAGTQATLAEHGLDRHWRNARTHTLHDPVRWKYHLVGNYYLNGVAPARHAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ML4</accession>
    <name>Q63ML4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199309.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110657.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0636"/>
    <dbReference type="EnsemblBacteria" id="CAH38094">
        <property type="protein sequence ID" value="CAH38094"/>
        <property type="gene ID" value="BPSS0636"/>
    </dbReference>
    <dbReference type="GeneID" id="56597678"/>
    <dbReference type="KEGG" id="bps:BPSS0636"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6827"/>
    <dbReference type="eggNOG" id="ENOG50336Z5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MNTDPRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9468" checksum="6AE67234255EB2A2" modified="2004-10-25" version="1">MTNQKPDDARPHDDEPKLEQLEAAVDHLHDSIQSQSIAAGAAKGILFSLIETLGALVGDPDLPEHARSGYEALRDKANELKANLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ2</accession>
    <name>Q63MQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523186.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110619.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0598"/>
    <dbReference type="EnsemblBacteria" id="CAH38055">
        <property type="protein sequence ID" value="CAH38055"/>
        <property type="gene ID" value="BPSS0598"/>
    </dbReference>
    <dbReference type="GeneID" id="56530950"/>
    <dbReference type="KEGG" id="bps:BPSS0598"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6776"/>
    <dbReference type="eggNOG" id="ENOG50343ST">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVECMIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009962">
        <property type="entry name" value="DUF1488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036692">
        <property type="entry name" value="Shew3726-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07369">
        <property type="entry name" value="DUF1488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160272">
        <property type="entry name" value="SSF160272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="95" mass="10695" checksum="BA9E6E6CEF8767DD" modified="2004-10-25" version="1">MQIQFTNDAPEYSGRELTLAFMAMVDGEPVQCHITAEALEDHFGAASPRFEDMVGAFDTHRPRIEAAARRLLSETRAQCVVLRSGYVRFYEANGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR3</accession>
    <name>Q63MR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyochelin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pchE</name>
        <name evidence="6" type="ordered locus">BPSS0586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205429.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110607.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0586"/>
    <dbReference type="EnsemblBacteria" id="CAH38043">
        <property type="protein sequence ID" value="CAH38043"/>
        <property type="gene ID" value="BPSS0586"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0586"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6762"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAPESIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1407"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1501" mass="159088" checksum="0142D4FF122322D8" modified="2004-10-25" version="1">MSQSAVDSISELSASSSDVFFRSRLVALLAELLGEPADDIAALGDDEDLLSYGVDSIRLMYMQTRLSRMGHALAFDALARTPTLGAWTALLARAMRAEPAAQGTDRAARADVVTNANANANANADADADADADANAKAKAKAKAKANADIDVHAEFELSAVQQAYWLGRGAGEVLGNVSCHAFLEFRSRGIDPQRLAAACRLVRARHPMLRARFVGGRQQIVAAPDAPVFDCRDWRGRAPAQAEAEWAALRAFRSHECLDIAHAQVFIAGLAQMPDGEDRVWLSIDLLAADVDSVRLLMNEIGAAYASPASLPDAPATWFPVYLAQRAAATRAAREAARGHWQARLADLPDGPALPLACAPESIRAPRFSRRAHTLSAAELARLRQRAAQHRVTLPSVFGYAFAAVLARWSGQHAFVLNVPLFDRHGEAPDLAAMIADFTTLLLVECEVRPHACVADAVRAFQACLHGAIAHAAYPALEVLRDARRQGAPRAAPVVFSSNLGDEPFVPAAFREAFGDLHDMISQTPQVWLDHQLYRVTDGVLLAWDSVDGLFPDGMLDAMFDAYIAFVQALCDRDWRQPAAVALPPAQRRVRDALNAVPAPGRPRTLHGDFFALAAREPAAVALWCGERAITRGELAAQALAIAAGLRAAGVGHGEAVEISLPRGPAQIAAAFGVLAAGACYVPVDVAQPPARRALIEQAAGIRAVIGVTPEPAATPPRLDAAALARGAPLAAPRPVAPRSTAYVIYTSGSTGVPKGVEMTHEAAMNTIDAINPLLGVSADDRLLAVSALDFDLSVYDLFGVLGAGGALVLPTQDEARDAARWIELIERHRVTLWNSAPALLEMALAAPGAAGACRSVRAVLASGDWIALDLPARLRARYGGACAFHALGGATEAGIWSNLQTVDAVPPHWRSIPYGRPLPGQAYRVVDDSGRDAPDHVAGELLIGGASLARGYRNDPVLSAARFVESDTGRWYRTGDRGRYWPDGTLEFLGRADRQVKVRGHRIELGEIEAALSAHPQVEGACASVVSGDAAHVVAAFVPVDVALDPASAGALAYRPAADTVQAQAAVTRAVLSRVLDGGARVPAPVRARWDAWLARASQPHAIALEAALEALDWPAARLDACAAALRALVDDPHGCAPRVLLDAQLAPQALASGLPDGVRAIGQIGAALRTLADAHARVVRVAVLDARAGQLFAHELRLLDDPRFALTLFDASPGLLRDAQSRFARTSPAMHAMPDGLLPARYLGQFDCVVSFAAAHLRDDPRDTFRLAAALLARDGHAFVADVLRDSPLRELTAALLGDASPPRLVSGEALAAAARACGFAPDAQSWRSDAFALIAARARAEPLTHARLAGWLRERLPDAMRPERLWCAPRWPLNGNGKIDRRAIGDALARTLGDAPAAHAAFAPADERQATLLACWEQALGRPADARDATFFALGGDSLLATRLLAQLRERLGVRIGMAEFYREPTLAGLAAKLAGAAAAVRGHRAAHAAAMEEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MX8</accession>
    <name>Q63MX8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196180.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110541.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0520"/>
    <dbReference type="EnsemblBacteria" id="CAH37977">
        <property type="protein sequence ID" value="CAH37977"/>
        <property type="gene ID" value="BPSS0520"/>
    </dbReference>
    <dbReference type="GeneID" id="56531031"/>
    <dbReference type="KEGG" id="bps:BPSS0520"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6680"/>
    <dbReference type="eggNOG" id="COG3519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICPLYMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028304">
        <property type="entry name" value="UCP028304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="620" mass="67835" checksum="1C7A595CA446362E" modified="2004-10-25" version="1">MNFLDHYNDELRQLRDAGARFSKEHPQVASALGLHPDAVTDPFVERLLEGVAYLSARVQKRLDRECAEFAQQALGRICPLYTASTPAISTFAFHPDLGSPDAFRGNTLPRGSLIAAHLPGRKLPVMFSTAREVTLLPLRLASVECSRSITGLPSLLAQRLASSHAVLRFRFEIEGGASIAELAREDDGFKPLHLSVAGDLPRAYALHRALLADTTAWYALVSTNRGDEVLPLPMSGIRLSGVDDEEALLPEAFGGLPGLRLLREYFAQPTRLLGVYVDALAAIAAKAPSARAFDLFFALRDAPGDLVGDVDASQFRLFATPAINLYSKRFDPVPYDANQPEQWIPVDRMRPAAHHLWALTEVFVCETNGRAHRARSVLETAGYEGHEGSIRYGMRREDALLVDGVRRDRFDPLASHDLIAVSMVDDTLEPDDVATITGRALVADRDWRPSALLDAELQLLDPTAVKRIECLWPASAPRGKPSIDACWEAVSHVGRNPLALRASQQQDVTARIVEQLLLAIDKDDALDRQRLESLRSVVLRSRFVAAGRATPTALVRATQVEIDIAESLHADRGGWLFGRLLAQALAEAATLNDGIEIVVRLDGEAASTHTNVATRDGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N23</accession>
    <name>Q63N23_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ordered locus">BPSS0474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525503.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110496.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0474"/>
    <dbReference type="EnsemblBacteria" id="CAH37930">
        <property type="protein sequence ID" value="CAH37930"/>
        <property type="gene ID" value="BPSS0474"/>
    </dbReference>
    <dbReference type="GeneID" id="56531076"/>
    <dbReference type="KEGG" id="bps:BPSS0474"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6623"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="320" mass="34304" checksum="1560EBF14E55E626" modified="2004-10-25" version="1">MNETLYGDGAIRRPSIYGSSVENTYAGVLSFMRRNYTRDLGGVDVAVCGVPLDLATTFRSGARLGPAAVRAASVQLAELRPYPWGFDPFDDLAVIDYGDCWFDAHNPLSIKPAIVEHARTILQSGAAMLTLGGDHYITYPLLIAHAQRHGKPLSLIHFDAHCDTWADDAPDSLNHGTMFYKAVNEGLIDPKTSVQVGIRTWNDDYLGIHVLDAAWVHEHGPRATAERIASIVGGRPAYLTFDIDCLDPAFAPGTGTPVAGGLSSAQALAIVRGLGGVNLIGADVVEVAPAYDQSEITAIAAAHVACDLLCLWRQRKTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NC5</accession>
    <name>Q63NC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525413.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110394.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0374"/>
    <dbReference type="EnsemblBacteria" id="CAH37822">
        <property type="protein sequence ID" value="CAH37822"/>
        <property type="gene ID" value="BPSS0374"/>
    </dbReference>
    <dbReference type="GeneID" id="56531159"/>
    <dbReference type="KEGG" id="bps:BPSS0374"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6500"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWMTGLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="152"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="299" mass="31858" checksum="ABFB6AEE8696838A" modified="2004-10-25" version="1">MNRYAFFLIASMLLVGSNVGIGKSIVAFVPVVILATLRFVIANAVLWPLFSPVKMRAVKRGEWLNLFLQAFFGTFMFTLLMLNGVQRTSAVAAGVITSTIPAVVALFAWLFLREKPNGRALVSIALAIVGVVTINVANGTASEGGAHASSLAGNLLMLGAVCCESIYVILSRRLTQTLAPIDICAYTHLFGLLLMLPLGAGALWHFDYASVPAGIWALVVWYGVSASIFSFWLWMKGIRHVPGSLAGVFSAVLPIAAAIYGILFLGERPTLAHGFALACVVTGIVLASLRVRRAPPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ND1</accession>
    <name>Q63ND1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TonB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSS0368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
            <orientation evidence="1 9">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110388.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0368"/>
    <dbReference type="EnsemblBacteria" id="CAH37816">
        <property type="protein sequence ID" value="CAH37816"/>
        <property type="gene ID" value="BPSS0368"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0368"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4362"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARTQPYN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="153"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH37816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="231" mass="23964" checksum="F1B19478A49FA60F" modified="2004-10-25" version="1">MNPRIVTAAVTVLAGHALLLTGALLMRNDVPHRPLESKTITAQLLSAPVAQPAGIQSAPAPTPPQPVPKAKPKPAPTPVPRPVAKSSRTPMPVTHEPAPNAITAPEPAPAAPVAPAETSAKAAPPAGAPTNRPTMEIVAPKEGAHLSCQIAKAAYPSMSKRRGETGVVKVRFVVGLTGKIESAQVVQSSGFARLDDAALDAIRSSPCQPYLQNGQPMRAAYTQPYDFTLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NH7</accession>
    <name>Q63NH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205389.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110342.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0322"/>
    <dbReference type="EnsemblBacteria" id="CAH37770">
        <property type="protein sequence ID" value="CAH37770"/>
        <property type="gene ID" value="BPSS0322"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0322"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4312"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SMLTDEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00273">
        <property type="entry name" value="TIGR00273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="482" mass="52508" checksum="26B63D707BC8E4BC" modified="2004-10-25" version="1">MSATPLNAPATFKARASAALHDAQLQEALGMLGEGWIEKRRRVVSLLPEFEMLRERAKAVKDHVLANLDTYLERYEAAVTRAGGVVHWANDAAQAREIVLRICRDANAKTITRGKSMVGEEIGLPAALEGAGMEVVETDLGEYIVQLAHEGPSHIVFPALHKTIGQVTELFAGNHSSAQYDGPRETVADVVGEARQVLREKFFVADVGITGANYLVAETGSNVICTNEGNGDLTSTLARVHIVTAGIERVVPTLDDVALFVRLLGRSATGQEITSYTTFSTGPRRGDDLDGPQEYHVVLVDNGRTRMLAGEFRDMLRCIRCGACMNHCPVYGAVGGHAYGWVYPGPMGAVLTPLLQGIEHDTDLPNACTLNGRCAEVCPVKIPLPTLLKKLRGMQFDARLTAPGTRFLLRAFGAIARRPALYHWLTRVGARALRALGGKRGSIARVPFASGWTDSRELPKPPPRTFFETWDATRTNQPEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P26</accession>
    <name>Q63P26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553085.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110143.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0122"/>
    <dbReference type="EnsemblBacteria" id="CAH37567">
        <property type="protein sequence ID" value="CAH37567"/>
        <property type="gene ID" value="BPSS0122"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0122"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6161"/>
    <dbReference type="eggNOG" id="COG3539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VAITCEE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010546">
        <property type="entry name" value="DUF1120"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06551">
        <property type="entry name" value="DUF1120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266207" evidence="1">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="23088" checksum="DFBC746D2D5B64F2" modified="2004-10-25" version="1">MKPKITFYAISIIIAQLWSANIQADTPNLDLMVKGTIDVPSCTVSVANNGIYDYGKILPTIITSGTGHTDLGKMTKAWSVNCDANTFMTFKVTDNRSESASVSSHDSRTLNTFGLGMVNKTGKLGYYTIKMTNPTVDGEATKLFNTLQTSDTDIYVRHSDIIQGWGSPNSLAIGRDFTADLTVNAYLAGTSIMAGPLTESIDLDGSTTLSFAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P27</accession>
    <name>Q63P27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative fimbrial chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the periplasmic pilus chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110142.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0121"/>
    <dbReference type="EnsemblBacteria" id="CAH37566">
        <property type="protein sequence ID" value="CAH37566"/>
        <property type="gene ID" value="BPSS0121"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0121"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4045"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPSAHVI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036316">
        <property type="entry name" value="Pili_assmbl_chap_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49584">
        <property type="entry name" value="SSF49584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266499" evidence="4">
        <location>
            <begin position="34"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="5">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="26004" checksum="BF7161307C38503B" modified="2004-10-25" version="1">MNSLMLSHILFRSSRIKTFLASLFAACSLQSHAATFTLENPTIIFNETDQRVAFNVKNDGESPMLLISKLEDLGEDKLSQRFLIAPPIARIDPGQSQQINFSLKKGAKLEHEYMLKASFEGVSQTGRGSLVMPVRQEIGFLVQAGAIPVSKTPWDNLKLSVKDKQLTLSNPSAHVIRLAPSVKLLPTNKMVALAHAYLMPGESRTVEIDDATDKIEIVPLSRYGLVLPAVTMPVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P67</accession>
    <name>Q63P67_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205330.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110102.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0079"/>
    <dbReference type="EnsemblBacteria" id="CAH37524">
        <property type="protein sequence ID" value="CAH37524"/>
        <property type="gene ID" value="BPSS0079"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0079"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6097"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CYERIER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021692">
        <property type="entry name" value="DUF3274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11678">
        <property type="entry name" value="DUF3274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="746" mass="82528" checksum="FF989A5F9756A379" modified="2004-10-25" version="1">MNGINDQCFTAARGAGVTMSNRPGDRPVPIPRDLPGVVIFIHGVNDPGAAYATVERGLCQGLNERLSRSDLRPGEYGRRYAAASAAKAEGDSVRYAEVLGDPDMYLYQRAETGGTHSMFLPFYWGYRASDNEIAKISHPGEVKSRVADSDGNLMTRGQYQDIHGNRLDAHFGKGGGFFANATNNIPQMYSPGFEPDKLERTVMQNALAGNTIFAGKSPERRYFVLAAARLANLIKTIRTIQPSALALEHGMDPQHETITVMGHSQGTIITLLAQAMLKQQGQRCVDCIIMVDTPYSLQFTQDGSQQTGHAKLKTLVDIVNAVTSEPHTIPELAELMIDSAHSCGRAGQNWSKTQGKRPDKGGKHWITFDERDNRGKVYLYFCPEDTVVGLDKVRGIGTFGVPDEVPADGAAASRGKTMPAMTVLEPKRFFQRMWTRLERDQDGRGKRSKVAVGTPPARVPVRDPFQRLTPGPDTDGTMLGTLVESGKNMALQASFKRNDIRFINGEQLKPAYEPDLYGGEVRKGGQVPGHADVAGLMRPDDVTKNVALGNQYAKFKWKDVATTDDPGAGIEPHKQAFNRGRPVDEQSHNWRIVPSRSLGSMLSAAATGGRYQTYVIQREETPDEVRKRMRTDADQLEANNYHSGVLLSSENHRWVTAMDVAIGQAVTLDDPDWRQLLLLMADWKMTSRAFKQMKECKAFNRLDKHTRDFLDACSTYYRTGQFPAEKFVMLTLPPLVTSELKAESKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PG0</accession>
    <name>Q63PG0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative branched-chain amino acid ABC transporter periplasmic substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524520.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110009.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3416"/>
    <dbReference type="EnsemblBacteria" id="CAH37428">
        <property type="protein sequence ID" value="CAH37428"/>
        <property type="gene ID" value="BPSL3416"/>
    </dbReference>
    <dbReference type="GeneID" id="56527738"/>
    <dbReference type="KEGG" id="bps:BPSL3416"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1770"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSAVTQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267033" evidence="1">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="27"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="398" mass="42905" checksum="3E97FCC710A95209" modified="2004-10-25" version="1">MKLKTLAHACLAVAAAWSVGAAQAADSVKIGFITDMSGLYADIDGQGGLEAIKMAVADFGGKVNGKPIEVVYADHQNKADIAASKAREWMDRGGLDLLVGGTNSATALSMNQVAAEKKKVYINIGAGADTLTNEQCTPYTVHYAYDTMALAKGTGSAVVKQGGKTWFFLTADYAFGKALEKNTADVVKANGGKVLGEVRHPLSASDFSSFLLQAQSSKAQILGLANAGGDTVNAIKAAKEFGITKTMKLAALLMFINDVHALGLETTQGLVLTDSWYWNRDQASRQWAQRYFAKMKKMPSSLQAADYSSVTTYLKAVQAAGSTDSDKVMAQLKKMKIDDFYAKGSIRTDGSMIHDMYLMEVKKPSESKEPWDYYKVVATIPGEQAFTTKQETRCALWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PK5</accession>
    <name>Q63PK5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acoD</name>
        <name evidence="6" type="ordered locus">BPSL3369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556617.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109964.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3369"/>
    <dbReference type="EnsemblBacteria" id="CAH37382">
        <property type="protein sequence ID" value="CAH37382"/>
        <property type="gene ID" value="BPSL3369"/>
    </dbReference>
    <dbReference type="GeneID" id="56594502"/>
    <dbReference type="KEGG" id="bps:BPSL3369"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1829"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RKAFEKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="27"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="506" mass="55412" checksum="6361037118E2AD9A" modified="2004-10-25" version="1">MNHADMQHLNIEFPYRKQYGNFIGGEWVAPVGGEYFDNVSPVTGRPFTAIPRSREADIELALDAAHAAKAGWAAKGAAERANVLLRIADRMEANLTRLAVAETIDNGKPLRETTAADVPLAIDHFRYFAGCIRAQEGSIADIGGDMVAYHFHEPLGVVGQIIPWNFPLLMAAWKLAPALAAGNCVVLKPAEQTPASILVFAELIQDLLPPGVLNIVNGFGLEAGKPLASSKRIAKIAFTGETSTGRLIMQYASENLIPVTLELGGKSPNIFFADVMDRDDSYFDKALEGFAMFALNQGEVCTCPSRALVEESIYDRFIERALKRVEAIKQGHPLDSQTMIGAQASAEQLEKILSYIDIGRGEGAQCLTGGERNVLGGELAEGYYVKPTVFRGHNKMRIFQEEIFGPVLAVTTFKTEEEALEIANDTLYGLGAGVWTRDGNRAYRFGRGIQAGRVWTNCYHAYPAHAAFGGYKQSGIGRETHKMMLDHYQQTKNLLVSYSEKPLGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PU0</accession>
    <name>Q63PU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109878.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3282"/>
    <dbReference type="EnsemblBacteria" id="CAH37295">
        <property type="protein sequence ID" value="CAH37295"/>
        <property type="gene ID" value="BPSL3282"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3282"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3734"/>
    <dbReference type="eggNOG" id="COG0748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KAHDFDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="28811" checksum="2CF0D2558CF141F4" modified="2004-10-25" version="1">MAGHALPPGAPSHAACPGAAQRAAHSRGDAADVSLPQARISHVNISAALPLHLLHRNVLGTLATHSRAPEGYPYPTVVPYAVDARHRPIVLVSGLAEHTRNLAADPRAGFLVVDGLGDAAGASDSVLEAERATLVGRFEPAGADPHVVARYLRYHPDGERYLALGDFTFWALACERLRYIGGFGRMGWLDATELDALAPVGYDDERALWDEYGASRERRAGLELLGVDRYGADWRLNGLKRRTPFDAPKMDVESLLAALREAAAVSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PU9</accession>
    <name>Q63PU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphosugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525680.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109869.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3273"/>
    <dbReference type="EnsemblBacteria" id="CAH37286">
        <property type="protein sequence ID" value="CAH37286"/>
        <property type="gene ID" value="BPSL3273"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3273"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1950"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDHIQGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="192" mass="19889" checksum="8253C4F50B08E310" modified="2004-10-25" version="1">MSVERIQQHIRDSAALVHEALEALSLPIAAAVDAMFMALANGNKIVACGDGPSAAAAERLAAALIGGFERERPGLPGLALDTDASRSGTGADGDQIFAQQVRTLGQTGDVLLVLDPLGESPRVLAAVEEAREREMIVIALTGNGGGCLGASLADTDIQICVPSERAVRIQEVHLLTIHCLCDGIDAMLLGED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q11</accession>
    <name>RL3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplC</name>
        <name type="ordered locus">BPSL3213</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521904.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109807.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q11"/>
    <dbReference type="SMR" id="Q63Q11"/>
    <dbReference type="STRING" id="272560.BPSL3213"/>
    <dbReference type="EnsemblBacteria" id="CAH37224">
        <property type="protein sequence ID" value="CAH37224"/>
        <property type="gene ID" value="BPSL3213"/>
    </dbReference>
    <dbReference type="GeneID" id="56594543"/>
    <dbReference type="KEGG" id="bps:BPSL3213"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2025"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000241326" description="50S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="219" mass="22967" checksum="01C1529B9090BA8F" modified="2004-10-25" version="1">MSLGLVGRKVGMTRIFTAEGDSIPVTVLDVSDNRVTQIKTVETDGYTAVQVAFGSRRASRVTKPLAGHLAKAGVEAGEILKEFRIEADKAAELSNGAVIGPDLFEVGQKVDVQGVSIGKGYAGTIKRYNFGSGRASHGNSRSHNVPGSIGMAQDPGRVFPGKRMTGHMGDETVTVQNLEIARIDADRKLLLVKGAVPGAKGGKVFVTPAVKTRAVKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QN6</accession>
    <name>Q63QN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522039.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109582.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63QN6"/>
    <dbReference type="STRING" id="272560.BPSL2988"/>
    <dbReference type="EnsemblBacteria" id="CAH36998">
        <property type="protein sequence ID" value="CAH36998"/>
        <property type="gene ID" value="BPSL2988"/>
    </dbReference>
    <dbReference type="GeneID" id="56528208"/>
    <dbReference type="KEGG" id="bps:BPSL2988"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2285"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SQQIARM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="312" mass="34031" checksum="404363B6E9767B75" modified="2004-10-25" version="1">MATLICGSIAYDNIMTFEGRFREHILPDQVHLINLSFLVPTMRREFGGCAGNIAYALNLLGGDARMMGTLGAVDAQPYLDRMDALGLSREYVRVLPDTYSAQAMITTDLDNNQITAFHPGAMMQSHVNHAGEAKDIKLAIVGPDGFQGMVQHTEELARAGVPFIFDPGQGLPLFDGATLRRSIELATYIAVNDYEAKLVCDKTGWSEDEIASRVQALIITRGEHGATIRHRDGNEQIPAVRAERVIDPTGCGDAFRGGLLYGIEHGFDWATTGRLASLMGSLKIAHQGPQTYAPTRAEIDARFETAFGYSPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QW5</accession>
    <name>ERPA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative iron-sulfur cluster insertion protein ErpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">erpA</name>
        <name type="ordered locus">BPSL2909</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for insertion of 4Fe-4S clusters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
        <text evidence="1">Binds 1 iron-sulfur cluster per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194247.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109503.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QW5"/>
    <dbReference type="SMR" id="Q63QW5"/>
    <dbReference type="STRING" id="272560.BPSL2909"/>
    <dbReference type="EnsemblBacteria" id="CAH36919">
        <property type="protein sequence ID" value="CAH36919"/>
        <property type="gene ID" value="BPSL2909"/>
    </dbReference>
    <dbReference type="GeneID" id="56593672"/>
    <dbReference type="GeneID" id="66548311"/>
    <dbReference type="KEGG" id="bps:BPSL2909"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2380"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01380">
        <property type="entry name" value="Fe_S_insert_ErpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023063">
        <property type="entry name" value="FeS_cluster_insertion_RrpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000311461" description="Putative iron-sulfur cluster insertion protein ErpA">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01380"/>
        </source>
    </evidence>
    <sequence length="122" mass="13093" checksum="3C3E586CCE194C69" modified="2004-10-25" version="1">MNAVTESAATTEMPAPFVFTDAAADKVKQLIDEEGNPDLKLRVFVQGGGCSGFQYGFTFDEEVNEDDTVLNKNGVVLLVDAMSYQYLVGAEIDYKDDLNGAQFVIKNPNATTTCGCGSSFSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R39</accession>
    <name>GLNE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glutamine synthetase adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamine synthetase adenylyl-L-tyrosine phosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.89</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Adenylyl removase</fullName>
                <shortName evidence="1">AR</shortName>
                <shortName evidence="1">AT-N</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamine synthetase adenylyl transferase</fullName>
                <ecNumber evidence="1">2.7.7.42</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Adenylyl transferase</fullName>
                <shortName evidence="1">AT</shortName>
                <shortName evidence="1">AT-C</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glnE</name>
        <name type="ordered locus">BPSL2835</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP</text>
            <dbReference type="Rhea" id="RHEA:43716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.89"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18589"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GlnE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.89" evidence="1"/>
    <dbReference type="EC" id="2.7.7.42" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109429.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63R39"/>
    <dbReference type="SMR" id="Q63R39"/>
    <dbReference type="STRING" id="272560.BPSL2835"/>
    <dbReference type="EnsemblBacteria" id="CAH36845">
        <property type="protein sequence ID" value="CAH36845"/>
        <property type="gene ID" value="BPSL2835"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2835"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3234"/>
    <dbReference type="eggNOG" id="COG1391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFMVQYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047388">
        <property type="term" value="F:[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000820">
        <property type="term" value="P:regulation of glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00802">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000209238" description="Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme">
        <location>
            <begin position="1"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl removase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl transferase" evidence="1">
        <location>
            <begin position="438"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00802"/>
        </source>
    </evidence>
    <sequence length="927" mass="102397" checksum="8F47F63626F0B687" modified="2004-10-25" version="1">MTMTDASDLLSLSYSHYLARAAAARPALAERIAAWAAAPVTRAALDARLDELLAQGGQPPSEDALKKALRQLRGEAFGAVAERDLAGRADVAEVTGTMTDLAEAAIQRALALLAAELEAQYGEPRGPSGERLALGVVGMGKLGGRELNVSSDIDLIFVYEDDGETAGGARGPISVHEFFTRLGRRLIGVLSEATADGYVFRVDMRLRPNGDSGPLVCSLGMLEEYFYVQGREWERYAWIKGRLVTERASAAARRLAQQLDAIVKPFVYRRYLDFGVIGAIRSLHEQIRQEARRRATMRPDKADDIKLGRGGIREIEFSAQVFQLIRGGQDAGFRVQPTLAVLRHASASGLITEEVRAGLTHAYLFLRTLEHRLQYRNDAQTHAMPVDPAERAALAASLGFADYAALIDRLDQHRAFVEAQFDQVFADKADGGARREDDQAAGCIWSGALADDGADEALVARLAELGFADPAAVLARLQAVWRSSRYAGLPESSRVRFDRVAHRALEAAPGIDAAHRDETVVRCFDLLETVGRRGAYLALLTEYPAALRRVLSVLGATRWGGGYLIRHPQLLDELLDDEAIDSPFDWPAFKDALRRRLAAADGAEHQMDLLRHAHQAEVFRILLLDLAGRLSVEHVSDRLSELADAMLDVTIEVVWSQLAKRHRDTPCFAAIAYGKLGGKELGYASDLDLIFLYDDPDERAADVYTTFARRLITWLTTATGAGTLFDIDLRLRPNGEAGLLVTDLDAFRRYQLREGDAANTAWVWEHQALTRARYSAGDARIGAAFEAIRVQVLTTPRDAAVLAREIVEMREKVLAGHPNTTERFDLKHDRGGMVDIEFAVQYWVLLHAARHPEMIRNTGNIALLREVSRFGLMSEEEAETVGAAYRTYRKLQHRLRLDGMEKARVEPERVAAERQAVAALWARVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RA4</accession>
    <name>Q63RA4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 6">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522195.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109364.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2769"/>
    <dbReference type="EnsemblBacteria" id="CAH36778">
        <property type="protein sequence ID" value="CAH36778"/>
        <property type="gene ID" value="BPSL2769"/>
    </dbReference>
    <dbReference type="GeneID" id="56528428"/>
    <dbReference type="KEGG" id="bps:BPSL2769"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2545"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FSATIWD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="32534" checksum="91EFD8A03EE60E8D" modified="2004-10-25" version="1">MLKVTKAVFPVAGLGTRFLPATKASPKEMLPIVDKPLIQYAVEEAIAAGITEMIFVTGRSKRAIEDHFDKSYEIEAELEARGKEKLLTLVRGIKPRHVDCFYVRQAEALGLGHAVLCAQKLVGDSPFAVVLADDLLDGRPPVLRQMIDVFNHYHTSVIGVEQIAPQDSKSYGVIDGKRWEDNLFKLSGIVEKPEPAAAPSNFGVVGRYVLTPRIFDHLRALKPGAGGELQLTDALQSLLKDEQVLAHRYDGLRFDCGSKIGYLKATVEFALRHPEVAPEFERYLSERFPELVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RB7</accession>
    <name>Q63RB7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109351.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2755"/>
    <dbReference type="EnsemblBacteria" id="CAH36763">
        <property type="protein sequence ID" value="CAH36763"/>
        <property type="gene ID" value="BPSL2755"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2755"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3146"/>
    <dbReference type="eggNOG" id="ENOG50317D3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CCRSMRG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="141" mass="14469" checksum="CBEA9903A68F03E0" modified="2004-10-25" version="1">MRSVDMTCCRSMRGSTLLEAAIACALLAVASLGVVAALLAAIRSERDTAACEPAVLVADSWAEMARAGGPSGVDWDASMSGLRHGKLVATNAGADISNVRVEWERSAGLAASPLRCDGDAAAARDAAKSCVTLAYASTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RD8</accession>
    <name>Q63RD8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable D-lactate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ldhA</name>
        <name evidence="5" type="ordered locus">BPSL2734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.28" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522216.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109330.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2734"/>
    <dbReference type="EnsemblBacteria" id="CAH36742">
        <property type="protein sequence ID" value="CAH36742"/>
        <property type="gene ID" value="BPSL2734"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2734"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2589"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIVTAHQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="4"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="334" mass="35950" checksum="D75976A90CD1B889" modified="2004-10-25" version="1">MRVILFSSRQYDHDSFDAANQSFGYRLHFQPSHLDAETAILARGYEVVCPFVNDTLDAAVLETLAAGGTRVIALRSAGFNHVDLAAAARLGLTVVRVPAYSPHAVAEHAVALILALNRRLPRAVARTREGDFSLNGLLGFDLFGKTVGVIGTGLIGSVFARIMTGFGMRVLAHSLPPHDDALIALGVRYVPLDALLAEADIVSLHCPLMPATHHMIDADALARMKPGAMLINTSRGGLVDTQALIDALKTGQLGHLGLDVYEEESGLFFEDHSDRPLQDDVLARLLTFPNVIVTSHQAFFTREALAEIAHTTLSNIRAWQDGAPQNVVDAGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RJ6</accession>
    <name>Q63RJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wbiE</name>
        <name evidence="3" type="ordered locus">BPSL2676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546257.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109272.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2676"/>
    <dbReference type="EnsemblBacteria" id="CAH36684">
        <property type="protein sequence ID" value="CAH36684"/>
        <property type="gene ID" value="BPSL2676"/>
    </dbReference>
    <dbReference type="GeneID" id="56528521"/>
    <dbReference type="KEGG" id="bps:BPSL2676"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2666"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHARRKH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="315"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="613" mass="70018" checksum="93AEE0CADCC7AA56" modified="2004-10-25" version="1">MRFDISVVVYRETEETLDDLLDSLAAQASCPDTVVRVWLRNNDPADADRWDRFVHDRSWYPFEISISHSPQNVGFGRAHNATFEMADAPFFFVLNPDTRLHSTAVSALRKAIDTSAGDVGAWELRQLPYEHPKLYDPVSLSTDWVTGAAVVFRRAAFAQVRGFEPRIFMYGEDVDLSWRMRAAGWVLHYVPHAVVVHPTYSKPMEAKPLQIAGGVVASLQLRTRFGSWLDIARGLGCWVAELARPARFPHARRTHLMALARYLRSAAYFRRTGARYRKGGFRPGFRFWGYGDRRDGAFFAFAVEELDARTVPLVSIIVRTHRRPALLREALMSLSHQTYPRVEVIVVEDGEPNSRAMIEREFAGRLDIRYEATGMPVGRSAAGNLGLSLAAGEWLGFLDDDDQFYADHVEAMMQVARSGTNRAVYGASHEIPTEFAQLTEEAATYREEPASLKYRPYSRLAMWQENLAPIQAVLFHRSLYDELGGFDEDLDQLEDWVLWVRYSCATDFSSFLRVTSRYRVPMAAKVAVERQAKLHEAYAVALERQRAMRVTLSPFDVVAMAEEQARRHAIVHVSRQTARKLIVRVPFMRTLLSSQAGWRRRMRALYRRMSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR2</accession>
    <name>Q63RR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, membrane permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185577.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109205.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2609"/>
    <dbReference type="EnsemblBacteria" id="CAH36617">
        <property type="protein sequence ID" value="CAH36617"/>
        <property type="gene ID" value="BPSL2609"/>
    </dbReference>
    <dbReference type="GeneID" id="56594867"/>
    <dbReference type="KEGG" id="bps:BPSL2609"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2746"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIVFQRQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="31486" checksum="34C7D0D7A6B8BF26" modified="2004-10-25" version="1">MQPKMTLSRAVIYAALILFALYFLFPIYVMLSTSFKDLDQLRTGNLLTPPSSWTVAPWAKAWGEACTGVRCEGMKPFFFNSIKMVIPAVLISSLIGAFNGYVLTHWRFRGADALFTMLLVGCFIPFQVILLPMARLQGYFGMANTIPGLVLVHVVYGIAFTTMFFRNFYVSVPAELVKAARIDGAGFFTIFTKILLPVSLPIFMVCLIWQFTQIWNDFLFGIVFSGVDSMPITVALNNLVNTSTGVKEYNVDMAGAIIAALPTLLVYVIAGRYFVRGLTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU3</accession>
    <name>Q63RU3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552544.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109174.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2577"/>
    <dbReference type="EnsemblBacteria" id="CAH36585">
        <property type="protein sequence ID" value="CAH36585"/>
        <property type="gene ID" value="BPSL2577"/>
    </dbReference>
    <dbReference type="GeneID" id="56526545"/>
    <dbReference type="KEGG" id="bps:BPSL2577"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2786"/>
    <dbReference type="OMA" id="ATWRDPI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="100" mass="10547" checksum="A12F81C60866EC28" modified="2004-10-25" version="1">MNNIIVHVPVGAQQHVVTAAGRPYSASPGNPISVPAEDAMILGGWGWILGARGNPMATEGSSANRPTAPVVNDRHLDYDCGRQIFWDGATWRDPITGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RW4</accession>
    <name>Q63RW4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205191.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109153.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2556"/>
    <dbReference type="EnsemblBacteria" id="CAH36564">
        <property type="protein sequence ID" value="CAH36564"/>
        <property type="gene ID" value="BPSL2556"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2556"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2809"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WQFWQRL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="3">
        <location>
            <begin position="208"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="381" mass="41162" checksum="DB3ACA91DD35ED3D" modified="2004-10-25" version="1">MSASPPPHPAIDTPLAFVDLETTGGSAAEHRITEIGVVVVNANGTSTWTTLVDPQQPIPPFIQQLTGITDAMVRGAPTFADIAGALFERLDGKLFVAHNASFDRGFLRAEFERAGIAFNPDVLCTVRLSRALFPRESRHGLDALIERHALAPSARHRALADADLIWQFWQKLHAVIPAEQLSEQIVRTTRRFRLAGALTEAHLESAPAGCGVYALFGDGDAPLYVGRSVRVRQRLRALLTGERRSSKETRLAQLVRRVEWRETGGELGALLAEADWIASLAPSFNRRSDRGATGDAHWPFGGPVAFEERGESRVFHVIDQWRYVGAASSIERAATLAADARAAGEGARSAAPAVRRILQTHLARGLQLIPIPLAGAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S04</accession>
    <name>Q63S04_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroA</name>
        <name evidence="11" type="synonym">tyrA</name>
        <name evidence="11" type="ordered locus">BPSL2517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2517"/>
    <dbReference type="EnsemblBacteria" id="CAH36524">
        <property type="protein sequence ID" value="CAH36524"/>
        <property type="gene ID" value="BPSL2517"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2517"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIHDCAN"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="341"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="487"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="753" mass="79202" checksum="0433C96C00819443" modified="2004-10-25" version="1">MALVVSVFYFDKLVIFGVGLIGGSLALALREGASGGRREVVGVGRSSASIGRALALRVIDRAAALDDDAQLRDALAGADLVLLAAPVAQTGPLLARIAPFLDASTIVTDAGSTKSDVVAAARAALGARIGQFVPGHPIAGRESSGVDAALADLYVGRNVVLCALPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAAVSHLPHVLSFALVEQILGESDAELKFSYAAGGFRDFTRIAASSPEMWRDVCLANRAALLDELDAYTAVLARLRAAIDAGDGAALEAVFARSRAARAAWRERGAKPAPAVRSDTSGTGSHMEHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGVKLSRDGGTCVVGGTRGAFTAKTADLFLGNAGTAVRPLTAALAVNGGEYRIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATISVDAPIRVRGDVSSQFLTALLMTLPLVKAKDGASVVEIDGELISKPYIEITIKLMARFGVTVERDGWQRFTVPAGVRYRSPGTIMVEGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIEVRGIGHDHGRLAPIDMDFNLIPDAAMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTPNASIDTYDDHRMAMCFSLVSLGGVPVRINDPKCVGKTFPDYFDRFLALANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SN7</accession>
    <name>Q63SN7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192531.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108879.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2283"/>
    <dbReference type="EnsemblBacteria" id="CAH36286">
        <property type="protein sequence ID" value="CAH36286"/>
        <property type="gene ID" value="BPSL2283"/>
    </dbReference>
    <dbReference type="GeneID" id="56596077"/>
    <dbReference type="KEGG" id="bps:BPSL2283"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3146"/>
    <dbReference type="eggNOG" id="COG2975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AIQQAWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007479">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036762">
        <property type="entry name" value="IscX-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37532">
        <property type="entry name" value="PTHR37532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04384">
        <property type="entry name" value="Fe-S_assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039003">
        <property type="entry name" value="IscX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140319">
        <property type="entry name" value="SSF140319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03412">
        <property type="entry name" value="iscX_yfhJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="69" mass="8068" checksum="E304ED0C5D6DC17B" modified="2004-10-25" version="1">MKWTDSREIAIALADQHPDVDPKTIRFTELRQWVLDLDGFDDDPDHSGEKILEAIQAHWIDESDFDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T05</accession>
    <name>Q63T05_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="5" type="ordered locus">BPSL2166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205139.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108761.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2166"/>
    <dbReference type="EnsemblBacteria" id="CAH36168">
        <property type="protein sequence ID" value="CAH36168"/>
        <property type="gene ID" value="BPSL2166"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2166"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3284"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="518"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="251"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="405"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="694"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129041" checksum="7F2C4B3801526982" modified="2004-10-25" version="1">MRLSSIKLAGFKSFVDPTHFQVPGQLVGVVGPNGCGKSNIIDAVRWVLGESRASELRGESMQDVIFNGSTTRKPGSRASVELIFDNSDGRAAGQWGQYGEIAVKRVLTRDGTSSYYINNLPARRRDIQDIFLGTGLGPRAYAIIGQGMIARIIEAKPEELRVFLEEAAGVSKYKERRRETENRLHDTRENLTRVEDIVRELGANLEKLEAQAVVATKYKELVADGEEKQRLLWLLRKNEAAAEQDRQRRAIGDAQIELDAQTAKLREVEAQLETLRVAHYSASDAMQGAQGALYEANAEVSRLEAQIKFIVESRNRVQAQIAALVAQQEQWRAQADKAQGDLEVAEEARAVADEKAAIAEDDAAAKHDALPALEARWRDAQTGLNDERGRIAQTEQALKLEAAHQRNADQQLQQLQQRHERLKVEAGGLDAPDEAQLEELRMQLAEHEAMLAEAQARLADAQEALPRLDAQRRAAHERVQAESAQIHQLEARLAALKQLQENVQTQGKIQPWLDKHELGALPRLWKKLHVEAGWETALEAVLRERLAALEVSNLDWVKAFATDAPPAKLAFYAPPAAGEPLAAPGALRPLLPLVRIDDAGLRAVLNDWLGTVFVADDLAQALAARMQLPQGGAFVVKAGHVVTRSGVQLYAADSEQAGMLARAQEIENLTRQVRAQALLSDEAKAAAIRAEAAHTQASQALTEVRAQAERATQRVHALQMDVLKLTQAHERYTQRSTQIREELEEIGAQIEEQRALRAESEANFERHDAELAELQARFEDNQLAFESLDETLTNARQEARERERAATDARFAARQSANRIDELKRSIQVAYEQAERVAASLEDARAELETINEQTAHTGLQDALEVRAAKEQALGAARAELDDLTAKLRAADEARLAAERSLQPLRDRITELQLKEQAARMTGEQFAEQLATAEVDEAALKEKLMPDMKPSYLQGEVTRINNAINALGAVNMAALDELAAASERKVFLDAQSADLTNAIETLEDAIRKIDQETRALLQATFDEVNRHFSDLFPRLFGGGQAKLIMTGDEILDAGVQVMAQPPGKKNATIHLLSGGEKALTATALVFAMFQLNPAPFCLLDEVDAPLDDANTERFANLVRAMSDKTQFLFISHNKIAMEMAQQLIGVTMQEQGVSRIVAVDMETAAGFAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T39</accession>
    <name>Q63T39_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521206.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108727.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2130"/>
    <dbReference type="EnsemblBacteria" id="CAH36133">
        <property type="protein sequence ID" value="CAH36133"/>
        <property type="gene ID" value="BPSL2130"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2130"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3327"/>
    <dbReference type="eggNOG" id="COG4312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETGIWWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="254" mass="28472" checksum="E52AE829AF9FABB1" modified="2004-10-25" version="1">MATHPTGTRDEWLAARLELLDAEKAHTRRGDALARQRAALPWVRVDKAYRFDTDEGGASLADLFRGRSQLLVYHFMFGPDYAAGCPSCSALADGFDGFVVHLAHHDVTLAAVSRAPLAKLRAYRTRMGWRFAWASSLDGDFNYDFNVSFTEAQQRDGSVEYNYRRGGHAMDVTPAPAPVAGFAADCGTDARTYARDRPGMSAFVLEDGAVYHTYSTYARGLDGLWGMYQWLDRAPKGRNETGVWWRRHDEYDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T59</accession>
    <name>Q63T59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521228.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108707.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36113">
        <property type="protein sequence ID" value="CAH36113"/>
        <property type="gene ID" value="BPSL2110"/>
    </dbReference>
    <dbReference type="GeneID" id="56529086"/>
    <dbReference type="KEGG" id="bps:BPSL2110"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3361"/>
    <dbReference type="eggNOG" id="COG3360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYQVGLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="69" mass="7958" checksum="3279B39783D4EC3F" modified="2004-10-25" version="1">MNDHVYKLIELTGSSRQSSDDAIRNAINKAAKTVRNLHWFEVTDMRGHIEGDQVIHWQVTLKVGLRIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TP3</accession>
    <name>Q63TP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193481.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108523.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35923">
        <property type="protein sequence ID" value="CAH35923"/>
        <property type="gene ID" value="BPSL1923"/>
    </dbReference>
    <dbReference type="GeneID" id="56595464"/>
    <dbReference type="KEGG" id="bps:BPSL1923"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4067"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERSIVMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="32487" checksum="EB49B9B321933799" modified="2004-10-25" version="1">MNITLRQLRVFIEVARLKSFSRAGDEIGLTQSAVSRSVRELEGEIGLKLIDRTTRDVQLTDVGTNLIASVSRLLGDLDDALREIREIGEQRRGRVIVAASPTIACRLMPRVVAACERRFPFVTLGLRDDVQSDVLRKVKSGEVDFGVVIGPLATSELISEPLMTDSFCLVARADHPLAARDRVPWTALAGERLVLLDYASGSRPLIDAALAAHRVAAGVVQELGHSATVFGLVEAGVGVSVLPWLSLPLPAGSSLVARPLAPRAERTVELVRRRDRSLSPAADAVWGLVKEMPARVEDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TT2</accession>
    <name>Q63TT2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550540.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108484.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35884">
        <property type="protein sequence ID" value="CAH35884"/>
        <property type="gene ID" value="BPSL1885"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1885"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4027"/>
    <dbReference type="eggNOG" id="ENOG5033A3X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KWRKHYY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024446">
        <property type="entry name" value="PXPV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12778">
        <property type="entry name" value="PXPV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267551" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="90" mass="9936" checksum="BEBD52E1618F6BE7" modified="2004-10-25" version="1">MEKWLTITMLGVALLGAAGAATAGGVDLSIGVGVPVAPVYVAPQPVYVAPQPAVVGYPAYGWRGDDEDDDWKHYRKHWRKWHRHHDDDDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TV1</accession>
    <name>PYRD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="1">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DHOdehase</fullName>
            <shortName evidence="1">DHOD</shortName>
            <shortName evidence="1">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrD</name>
        <name type="ordered locus">BPSL1866</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534868.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108465.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TV1"/>
    <dbReference type="SMR" id="Q63TV1"/>
    <dbReference type="STRING" id="272560.BPSL1866"/>
    <dbReference type="EnsemblBacteria" id="CAH35865">
        <property type="protein sequence ID" value="CAH35865"/>
        <property type="gene ID" value="BPSL1866"/>
    </dbReference>
    <dbReference type="GeneID" id="56529559"/>
    <dbReference type="KEGG" id="bps:BPSL1866"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4000"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148429" description="Dihydroorotate dehydrogenase (quinone)">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="321"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <sequence length="342" mass="36323" checksum="796E35619C05A53C" modified="2004-10-25" version="1">MFSSLYPLARASLFKMDAEDAHHLTLRMLGAAGRTGLACALSPRVPDAPRTVMGLSFRNPVGLAAGLDKDGAAIDGFAALGFGFIEVGTVTPRAQPGNPRPRMFRLPEADAIINRMGFNNSGVDQFVKNVQAARYRGVLGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQRRLADLHGKLVPLALKIAPDLDDEQVKEIAATLLRHDIEGVIATNTTLSREAVKGLPHADEAGGLSGRPVFDASNAVIRKLRAELGDAVPIIGVGGIFSGEDARAKLAAGAALVQLYTGFIYRGPALVAECVKAIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U06</accession>
    <name>Q63U06_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004542282.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108410.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1811"/>
    <dbReference type="EnsemblBacteria" id="CAH35810">
        <property type="protein sequence ID" value="CAH35810"/>
        <property type="gene ID" value="BPSL1811"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1811"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3932"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VATSYCQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="142" mass="14782" checksum="229CFC3D12433692" modified="2004-10-25" version="1">MKRLARLVHDERGVVSLEFVLAFPFMMLVLFGIVDTSLLLCDKAVITNASREAARAGVVVRVPQLAATDITNIALSYARGSLVSGGTVGAPVVNVDQSAGTSPGSPLKVTVSYTYQGLVLGSALSALTGPITLTAVTVMNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U69</accession>
    <name>Q63U69_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521540.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108347.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1747"/>
    <dbReference type="EnsemblBacteria" id="CAH35746">
        <property type="protein sequence ID" value="CAH35746"/>
        <property type="gene ID" value="BPSL1747"/>
    </dbReference>
    <dbReference type="GeneID" id="56529432"/>
    <dbReference type="KEGG" id="bps:BPSL1747"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3847"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMDDAWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="149" mass="14631" checksum="244B03D2D249E13A" modified="2004-10-25" version="1">MSPELTLERALRIVEAGVAHAARLSAAGAAVAIAVVDAGAHLAAFARMDDAFIGAIDLATRKAGTAARFRMPSASLGALSGAGGPVRSIEHSNGGLVTFGGGLPLVDAHGRCVGAVGVSGGTVDDDAAIAQVCVDAFITLLNAAQGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UK0</accession>
    <name>Q63UK0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome c-related lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL1600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521401.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108216.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1600"/>
    <dbReference type="EnsemblBacteria" id="CAH35600">
        <property type="protein sequence ID" value="CAH35600"/>
        <property type="gene ID" value="BPSL1600"/>
    </dbReference>
    <dbReference type="GeneID" id="56529322"/>
    <dbReference type="KEGG" id="bps:BPSL1600"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3659"/>
    <dbReference type="eggNOG" id="COG3245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MMGAPKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002323">
        <property type="entry name" value="Cyt_CIE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40942">
        <property type="entry name" value="PTHR40942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00607">
        <property type="entry name" value="CYTCHROMECIE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266595" evidence="8">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="9">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="16118" checksum="CFD82CA9ED94C280" modified="2004-10-25" version="1">MKLRNLSITAAAFALAFGLSACGQRDAGAPPAAAASASIAPAASVTLDASANASPSAASAPAASSEAAPAATTAAAADTPNPGGEKVFKSVCFMCHQTGAAGAPIAGNKDDWAPRIAQGKPTLYKHALEGFTGNKGTMPPRGGNPSLKDNEVEAAVDFMVAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UP1</accession>
    <name>Q63UP1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putrescine-binding periplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">potF</name>
        <name evidence="3" type="ordered locus">BPSL1555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the activity of the bacterial periplasmic transport system of putrescine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein PotD/PotF family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521361.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108175.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1555"/>
    <dbReference type="EnsemblBacteria" id="CAH35556">
        <property type="protein sequence ID" value="CAH35556"/>
        <property type="gene ID" value="BPSL1555"/>
    </dbReference>
    <dbReference type="GeneID" id="56529280"/>
    <dbReference type="KEGG" id="bps:BPSL1555"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3601"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SNWTEYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267165" description="Putrescine-binding periplasmic protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="364" mass="40166" checksum="C50B35D5A38DC413" modified="2004-10-25" version="1">MKAKVAGRLTALALCAGATVAAAKDTQLNVYNWSDYIAKDTIPNFEKQTGVKVRYDNYDSDDTLQAKLLTGNSGYDIVVPTSNYAGKQIQAGIFTPLDKSKLPNLKYLDAQLMALVAGADPGNKYVVPWAYGTTGLGYNVDKAQKVLGKVPLDNWDILFKPENLSKLKTCGVSVLDAPDQMFAATLHYIGKDPMSTNPADYQAAMQVLKKIRPYITQFNSSGYINDMVGGDICFAFGWSGDVVIAKHRALEAKKPYKLEYYVPKGGAPVWFDVMAIPKDAKNKDAALQWINYIEDPKVHASITNAVYYPSANAQARKYVRPDVANDPAVYPPPDVVKTLFLLKPLPPEIQRLQTRLWTELKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UW2</accession>
    <name>Q63UW2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">clpB</name>
        <name evidence="15" type="ordered locus">BPSL1484</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108104.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1484"/>
    <dbReference type="EnsemblBacteria" id="CAH35485">
        <property type="protein sequence ID" value="CAH35485"/>
        <property type="gene ID" value="BPSL1484"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1484"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1667"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="14">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="423"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="876" mass="97278" checksum="8D3137765396EA7B" modified="2004-10-25" version="1">MVAIRKLEVSFMRIDKLTTKFQEALSDAQSLAAGRDNQYIEPVHVLAALVAQQDGSARSLLSRAGVHIQALQGALNEAISRLPQVTGTGGDIQVGRELAGLLNQADKEAQKLNDTFVASEMFLLAVADDKGEAGKLARQHGLTRRALESAIAAVRGGSQVHSQDAESQREALKKYTVDLTERARAGKLDPVIGRDDEIRRSIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLSLDMAALLAGAKYRGEFEERLKAVLNDIAKDEGRTIVFIDEIHTMVGAGKAEGAMDAGNMLKPALSRGELHCIGATTLDEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAASRIKMEIDSKPEEMDKLDRRLIQLKIEREAVKKEPDEASQKRLALIEEEIERLGREYADLDEIWTAEKAAVQGSAQLKEEIDKVRADIARLQREGKLEKVAELQYGKLPQLEARLKQVTQAEESEQHNPTRPRLLRTQVGAEEIAEVVSRATGIPVSRMMQGEREKLLHIEEKLHERVVGQNEAIDAVADAIRRSRAGLADPNRPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEIEKAHPDVFNVLLQVLDDGRMTDGQGRTVDFKNTVIVMTSNLGSQLIQSMSGSPQEEIKDAVWVEVKQHFRPEFLNRIDDVVVFHSLDRGNIQAIAKIQLARLHDRLAKLDMALDVSEAALEQIGKVGYDPLFGARPLKRAIQQEIENPVAKLILAGRFGPKDVIPVDMQDGRFVFERVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V06</accession>
    <name>Q63V06_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527197.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108060.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1438"/>
    <dbReference type="EnsemblBacteria" id="CAH35440">
        <property type="protein sequence ID" value="CAH35440"/>
        <property type="gene ID" value="BPSL1438"/>
    </dbReference>
    <dbReference type="GeneID" id="56529161"/>
    <dbReference type="KEGG" id="bps:BPSL1438"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3460"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFAHNQP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="168" mass="18290" checksum="0AE7C3B79EF7EDC1" modified="2004-10-25" version="1">MTQLAYRDATPADLPAIVAIYNSTVASRRVTADTEPVTVDSRRAWFDAHNPHARPLWVVEEAGRVIAWLSFSDFYGRPAYGHTAEISIYLDEAARGSGLGSRLLEAALAKAPALGVHTALGFIFGHNEPSLRLFARYGFTAWGTLPRVAVLDGIERDLVIVGKRLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD2</accession>
    <name>Q63VD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535882.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107934.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35307">
        <property type="protein sequence ID" value="CAH35307"/>
        <property type="gene ID" value="BPSL1310"/>
    </dbReference>
    <dbReference type="GeneID" id="56595232"/>
    <dbReference type="KEGG" id="bps:BPSL1310"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.182"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTQQPFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="513" mass="54622" checksum="7A009F86C100B79F" modified="2004-10-25" version="1">MARRARIIEIPSLGMLERTAGNLSRQLAQALRDAVRRGEVMPGDALPSTRLLAASLRIARGTVIDAYEQLIAEGFLESRGGVGTRVAPALAEPRGARRRAAAAARSALPPPAAEYARVAREFAPLPPAPFAISVPAGATAPDDVWRRLGNRLRARGPAAPAGYSDPLGVRALREAIAGYVRKSRSVHCAPDQIIVTSGAQQGLYLACQVLLGAHDRAWVENPAYRGLTAILECTGRRDAMVRVPVDAEGIDVDAGVRLARDARAAFVTPSHQYPLGMPMSMARRAALLAWARASGAWVVEDDYDSELRYEGYPFPSLQGLDPARVVYLGTFSKILFPSLRLGYLIVPDELVDALRGARVLMDRHAPTADQHVLAAFIAGGHFDRHIRRVRGVYAEQRAQLIDTVGRLLSGDLAWLQPGDQGMHAVLWLAAGVDDLRVAAMAAQAGVAVRPVSPMFAPGTARPGLVLGFGGFGREQMDAAARRLAEVIAAASGSAVPRAGAGRRRRDGAGGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VG2</accession>
    <name>Q63VG2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecBCD enzyme subunit RecB</fullName>
            <ecNumber evidence="8">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Exonuclease V subunit RecB</fullName>
            <shortName evidence="8">ExoV subunit RecB</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Helicase/nuclease RecBCD subunit RecB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recB</name>
        <name evidence="13" type="ordered locus">BPSL1283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204977.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107904.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1283"/>
    <dbReference type="EnsemblBacteria" id="CAH35277">
        <property type="protein sequence ID" value="CAH35277"/>
        <property type="gene ID" value="BPSL1283"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1283"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.225"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KQSIYRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01485">
        <property type="entry name" value="RecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004586">
        <property type="entry name" value="RecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF23">
        <property type="entry name" value="PTHR11070:SF23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00609">
        <property type="entry name" value="recB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="8"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="463"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="DNA-binding and helicase activity, interacts with RecC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nuclease activity, interacts with RecD and RecA" evidence="8">
        <location>
            <begin position="960"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="8">
        <location>
            <position position="1169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1043"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH35277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1270" mass="137336" checksum="65D198076FA6F631" modified="2004-10-25" version="1">MSHVAPSGPSASELDVFACPLDGVNQIEASAGTGKTWNICALYVRLLLEKDLGADEILVVTFTKAATAELHERIRARLAQLAHALDTGDDGGDPFIARLFETTLAPERGLDPQTAAKRVRRALRAFDQAAIHTIHAFCQRALQEAPFAAAMPFAFEMEADDGALRFELAADFWRTRVEPVAAAYPAFAEWLVEYGAGPAALDAQLARRLKKPLARLRWDGLHAADDGAESAARAHFDTAAAIWRDERGVLGTLLADAQPSLNQRSHKPEAVSEALDAWARYFEQASAVAALPRAALKLTQSALEKATKKGGATPRHAFFDVAQALEAAVAALEAAQRARWLSLVEQWLDAAPAELAQRKRTRRVVSFDDLLANLYRALDAHPWLRETLRARYPAALIDEFQDTDPLQFAIFDTIFAPAGPLFLVGDPKQAIYSFRAADLHTYLAARARASARYTLAVNQRSTPAIVGACNRVFGANPRAFVLDGLDYEPVRAGSRVRAPLVDATDPLAGAGDFRIWTLPAGDDVLTKRDAQRHAAHACAAEIARLMRGARERAVTLGGEPLAASGIAVLVQTHRQGSLVKRVLAAWGIGSVELAQASVFATIDAEQLERVLAAIDAPGDLRRLRSALASDWFGLDAAALWRLEQGDAEQDGIDAAARGASGNGGGARAASAGAPAPSPADADAMGWVERFSRYRLLWRERGFAVMWRTLAGELRIAERLMAGADGERRVTDVNHLAELTQARASAQPGIAPTLRWLAAQRLEGGGDDAQLRLESDRNLVQIVTVHKSKGLEYAIVFCPFLNDGGLREPAGSGLPDAREYHDESGCAVLHYGCDDEAAERASREAVREQAAERARLVYVALTRAVYRCYLVAGTYQSSRSTKEARRSVLNWLVAGAGRDFDAWLKEPPEDAELAERWQALAGGPVTLGALPVPAHREPLAAGHDAQATRAARRATRGLRDAWRIASFSSLASAIARDESGIARAADDEMRPDHDALAAALGADALEPPDAAAAIAPAPAAAPRELAEDDILAFPRGAAAGECLHRLLELSNFADASTWPPAALRALHERPVEAELALAERLPAMMTRLVADLAATELVPGMRLAALDPARRLTEMEFLFPAPALDFNALRRLLAAHGYPDVALEAGTLAGFVKGFIDMIVEHDGRFWIVDWKSNHLGTTPEAYGERALDAAMAHHAYHLQALLYMVALHRYLRVRMHGYDYDAHIAGYLYVFVRGVRPDWRNGGASAGVHARRPARALIEALDALMREGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU0</accession>
    <name>Q63VU0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107776.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1154"/>
    <dbReference type="EnsemblBacteria" id="CAH35149">
        <property type="protein sequence ID" value="CAH35149"/>
        <property type="gene ID" value="BPSL1154"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1154"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1272"/>
    <dbReference type="eggNOG" id="ENOG5033D95">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="14553" checksum="9358CA1A2E45DBEA" modified="2004-10-25" version="1">MFRRPHNMSTKKMADPQASQDKENLNSNANVNTMFSKKPLGKIDRVLFELRRGISLNRFDAERLGDHCLNTTISTLRAEGWLIASEWETVPTRFGKTARVLRYRLTGYRNPAEVTDEIAAILGEGRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU6</accession>
    <name>Q63VU6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936868.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107770.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1149"/>
    <dbReference type="EnsemblBacteria" id="CAH35143">
        <property type="protein sequence ID" value="CAH35143"/>
        <property type="gene ID" value="BPSL1149"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1149"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.391"/>
    <dbReference type="eggNOG" id="ENOG5032QC3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HASYLEP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="92" mass="10245" checksum="75CC0AA4BD8C6481" modified="2004-10-25" version="1">MANLRCRPGDLARVIRAWNPALVGRIVLVGALHSIRESEWNVTLLGAPGMTLTKNRKRLRIGNRMLAHASYLEPLRGEELLGHVSEREASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VY6</accession>
    <name>Q63VY6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204947.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107730.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1109"/>
    <dbReference type="EnsemblBacteria" id="CAH35102">
        <property type="protein sequence ID" value="CAH35102"/>
        <property type="gene ID" value="BPSL1109"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1109"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.442"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWFGISA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="7">
        <location>
            <begin position="1487"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="757"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1124"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1183"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="1504"/>
            <end position="1511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1841" mass="182200" checksum="64362CD047712F74" modified="2004-10-25" version="1">MQTVVLGWFGFSAVWFIPLFWRLVKAALPGGGGLAGPGSIRLWLGFVGVLTASCTLATALTGDATTNALGHALARGFEHVFGHVGTPFAMIALFVVGLPWLVGVRWRQVNAWLDASFGIRFARERGDEEPRGVADLPRAALHRDDDRRVRRAADVQPTTAHTVNSMAPRQNGRYARPTLWKPNDAQRGERRSASAGGAARAAAEPTAPAGWLKPGAQPRGAQPAAAMATGAAGTAAAGASTAGFAKVAGAAAAASEPAKTAGGAMSAHHAPKTINPPLSVGGAPKAAGPAMTGSGAAKTPPPASAMPAPTIAAAKPAAATMPPSGLSKAERLAAPTGGAAAPLAAPAAAVTSPAAFAPAATGIAKPIGSTAAVAALGKRAQARPAAPDPRFAPRRPATQAAVSAARNRPMTFTPSRQTTGATPPQPAPRAQTAAPTAETARKRAPANPARAPLYAWHEKPAERIAPAASVHETLRSIEASAAQWTALAGATSTAATPVTARESMAAPAAPSGGAAASAAPDGHAPTSAETAAPNDHAPTSAETVAPDGHVPTSAETAAPDSHAPTSAETAAPDGHAPTSAETATPNDHASTSAETAAPDSHAPTSAETAAPDGHASTITEAAAPNGHVSATVETSAVAAPVGITQAAPPIAADTCPAGEHVIAAVEPAGTSDSAAIGAGAIAHAEAGAAASTAETASPIGVDTHIAPSREADRTAQTAPTAPSPAEATPHVDAPHALDVAARALVGNTAATAHGAAAVDGSAQRADTASPAASTSGPPAPVAASAASSDRAAPQPVATAAPASIATSGALGTMKAIGAAGPQPSTIAAQRASAIDDTGQPPSTGHSTHAAVSNELGRRPHAAPDAVTPALPPAAAARAAAVPTSASAVQRQALASESAEAAQGVARAAAAGDSRETTQVSPAGARPDKAAPSAAGANPIAPLPGASAITAHEDAPTSAAPDAATPVIAAMDSAMPNAVAPASAIASNAGMSPASASAAAPRMASAPASAAVPNTHPPLTRAAAAVPGVASIGVAAPGVIVTNAATALPAAPGRIASPAGASAVAPGAMTPNAASTDVAPAAAPASDVSPNVVPAPAVGANASVPPAGASSAARHVNAPMVASTGAAAPAPSIPSSLPPSTVTSNAERRATTTAPTAAPAGLAPNPVAASSFVAPTTSAAPGQFAPAATAPADNAPAAAEAPPGRVPNPPAGAGFVTPTSPTPGPLPPAAETPAATATPTAPPPGLAPNPPAGAGFAATPEAVAHPFGNPSAPAPGAIPESPATAPSVALTANGTEAPGAPQAFAPSPVPAMPAAPAAADPASAAPAAEPVRPSRPPAPNAFEFHAPAASNVELPTLDLLEPASDTIEAISDEHLAQTGQIIEQRLQEFKVPVTVVGASAGPVITRFEIEPALGVRGSQIVGLMKDLSRGLGLTSIRVVETIPGKTCMGLELPNAKRQMIRLSEILASRQYQHSASQLTIAMGKDITGNPVVTDLAKAPHMLVAGTTGSGKSVAINAMILSLLYKATPEDVRLIMIDPKMLELSVYEGIPHLLAPVVTDMKLAANALNWCVGEMEKRYRLMSALGVRNLASFNQKIRDAAAKEKKLGNPFSLTPEDPEPLSTLPLIVVVIDELADLMMVAGKKIEELIARLAQKARAAGIHLILATQRPSVDVITGLIKANIPTRVAFQVSSKIDSRTILDQMGAESLLGQGDMLFLPPGTGYPQRVHGAFVADEEVHRIVEYLKQFGEPQYEEGILDGPSAEGGTQDLFGEAPDAEADPLYDEAVAFVVRTRRASISSVQRQLRIGYNRAARLVEQMEAAGLVSPMGINGSREVLAPPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W16</accession>
    <name>Q63W16_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526398.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107700.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63W16"/>
    <dbReference type="STRING" id="272560.BPSL1078"/>
    <dbReference type="EnsemblBacteria" id="CAH35072">
        <property type="protein sequence ID" value="CAH35072"/>
        <property type="gene ID" value="BPSL1078"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1078"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.481"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMEGGYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="48"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="37387" checksum="872AC72DB0163811" modified="2004-10-25" version="1">MLTYFHPDQSLHHPRTYFSRGRMRMPQEVPERAARLVAAAFAMGFPVREPDDFGIAPIAAVHDTHYLRFLETVHREWKAMPEDWGDEAMSNIFVREPNALRGVLAQAARHLADGSCPVGEHTWRAAYWSAQSALAAAAAVRDGAPAAYALCRPPGHHARVDAAGGFCYLNNAAIAAQALRARHARVAVLDTDMHHGQGIQEIFYARRDVLYVSIHGDPTNFYPAVAGFDDERGAGEGLGYNVNLPMPHGSSEAAFFERVDDALRELRRFAPDALVLSLGFDVYRDDPQSQVAVTTDGFGRLGHLIGALRLPTVIVQEGGYHIESLEANARSFFGGFGALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W48</accession>
    <name>Q63W48_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107668.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1041"/>
    <dbReference type="EnsemblBacteria" id="CAH35037">
        <property type="protein sequence ID" value="CAH35037"/>
        <property type="gene ID" value="BPSL1041"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1041"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1131"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="53" mass="5703" checksum="D60EA957143487DB" modified="2004-10-25" version="1">MRTRAERTTKHTGVEATPARRPASAAAAVVAPRVAPLRHSNRQASAVNRDGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W87</accession>
    <name>Q63W87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane-attached superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522548.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107629.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1001"/>
    <dbReference type="EnsemblBacteria" id="CAH34997">
        <property type="protein sequence ID" value="CAH34997"/>
        <property type="gene ID" value="BPSL1001"/>
    </dbReference>
    <dbReference type="GeneID" id="56526834"/>
    <dbReference type="KEGG" id="bps:BPSL1001"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.568"/>
    <dbReference type="eggNOG" id="COG2032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHGFNNP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="4">
        <location>
            <begin position="53"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="179" mass="18207" checksum="374E9588AACF5A7C" modified="2004-10-25" version="1">MKRRLDGVPGWLALNAPLVLAAIGLLAGCTTFASQHEKRADALLQPTVGSQARGTVTLAERPDGVQVTYNFAGLPPNSDHALQVHERGDCNAADGSSAGAVFAPAADRLRAGARVGGDLGNIHADANGVAAGFITAPDLALDGVRSVLGRSVLVHRDPADPAFPQHGAGPALACGVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WD6</accession>
    <name>Q63WD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009919153.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107580.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="DNASU" id="3094019"/>
    <dbReference type="EnsemblBacteria" id="CAH34948">
        <property type="protein sequence ID" value="CAH34948"/>
        <property type="gene ID" value="BPSL0952"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0952"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.625"/>
    <dbReference type="eggNOG" id="COG5527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THARHDP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010522">
        <property type="entry name" value="RepC_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06504">
        <property type="entry name" value="RepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="287" mass="31934" checksum="68F3817344CDF81E" modified="2004-10-25" version="1">MTRTSPTHAKLAQPIVHAPGLFHSLAPGERKRDKLDVTHVAGDTTVRFVGFEPLDSTDLRVLQGLIALATAGLRNIRRLLRDGQSLRTSLDLKGDAQDERTVAARFTLASLADMAGFDRGGFGCRQMRASLQRLSNVTVLVDRPEFEGAFRLVSGYRLDKHTGELVVSISPLGTTAILGRQGYLRLNMDEVRRIHGEVAHLIHSRLHWVNQGDRRPVNMDTLCSYAYVGVRTGSALRKRRMAVRQALKELMDVGWTVTEKYPGTYLIGRPRRASDQGELVTRAGVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WR6</accession>
    <name>Q63WR6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sorbitol dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540951.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107450.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0826"/>
    <dbReference type="EnsemblBacteria" id="CAH34817">
        <property type="protein sequence ID" value="CAH34817"/>
        <property type="gene ID" value="BPSL0826"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0826"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.775"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AKDANTM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="27644" checksum="AFABDF9035EC03F6" modified="2004-10-25" version="1">MRLQEKVAILTGAASGIGEAVARRYLEEGARCVLVDLKPADGALARLIDAHAGRAIAVSADVTRRDDIARIVATAVERFGGVDILFNNAALFDMRPLLDESWDVFDRLFAVNVKGLFFLMQAVAQRMVEQGRGGKIVNMSSQAGRRGEALVSHYCATKAAVLSYTQSAALALARHGINVNGIAPGVVDTPMWEQVDALFARYENRPLGEKKRLVGEAVPLGRMGVPDDLTGAALFLASADADYITAQTLNVDGGNWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WS7</accession>
    <name>Q63WS7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bpeB</name>
        <name evidence="5" type="ordered locus">BPSL0815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530869.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107439.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0815"/>
    <dbReference type="EnsemblBacteria" id="CAH34806">
        <property type="protein sequence ID" value="CAH34806"/>
        <property type="gene ID" value="BPSL0815"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0815"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.788"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMYMSSS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="874"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="924"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1066" mass="114731" checksum="B3933DA342874D48" modified="2004-10-25" version="1">MAKFFIDRPIFAWVIAIILMLAGVAAIFTLPIAQYPTIAPPSIQITANYPGASAKTVEDTVTQVIEQQMSGLDNFLYMSSTSDDSGNATITITFAPGTNPDIAQVQVQNKLSLATPILPQVVQQLGLSVTKSSSSFLLVLAFNSEDGSMNKYDLANYVASHVKDPISRINGVGTVTLFGSQYAMRIWLDPTKLTNYGLTPVDVTSAISAQNVQIAGGQLGGTPAVPGTVLQATITEATLLQTPEQFGNILLKVNQDGSQVRLKDVAQIGLGGETYNFDTKYNGQPTAALGIQLATNANALATAKAVRAKIDEMSAYFPHGLVVKYPYDTTPFVRLSIEEVVKTLLEGIVLVFLVMYLFLQNLRATIIPTIAVPVVLLGTFAIMSMVGFSINVLSMFGLVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKAMGQITGALVGVALVLSAVFVPVAFSGGSVGAIYRQFSLTIVSAMVLSVLVALILTPALCATILKPIPQGHHEEKKGFFGWFNRTFNSSRDKYHVGVHHVIKRSGRWLIIYLAVIVAVGLLFVRLPKSFLPDEDQGLMFVIVQTPSGSTQETTARTLANISDYLLTQEKDIVESAFTVNGFSFAGRGQNSGLVFVKLKDYSQRQSSDQKVQALIGRMFGRYAGYKDALVIPFNPPSIPELGTAAGFDFELTDNAGLGHDALMAARNQLLGMAAKDPTLRGVRPNGLNDTPQYKVDIDREKANALGVTADAIDQTFSIAWASKYVNNFLDTDGRIKKVYVQSDAPFRMTPEDMNIWYVRNGSGGMVPFSAFATGHWTYGSPKLERYNGISAMEIQGQAAPGKSTGQAMTAMETLAKKLPTGIGYSWTGLSFQEIQSGSQAPILYAISILVVFLCLAALYESWSIPFSVIMVVPLGVIGALLAATLRGLENDVFFQVGLLTTVGLSAKNAILIVEFARELQQTENMGPIEAALEAARLRLRPILMTSLAFILGVMPLAISNGAGSASQHAIGTGVIGGMITATFLAIFMIPMFFVKVRAVFSGEKEDADEALRLAHEHMHRDDKPEHGDDAGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WW0</accession>
    <name>Q63WW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107406.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0781"/>
    <dbReference type="EnsemblBacteria" id="CAH34773">
        <property type="protein sequence ID" value="CAH34773"/>
        <property type="gene ID" value="BPSL0781"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0781"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.838"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ILAMRFV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022301">
        <property type="entry name" value="Integral_membrane_YjbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03717">
        <property type="entry name" value="R_switched_YjbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="270" mass="28663" checksum="1679C704A9EE64B1" modified="2004-10-25" version="1">MLAQSFRQPRVGLAGKSGTHADARRSHFLCLASMFEFFASLHWGAVAQIVVIDILLGGDNAVVIALACRNLPAQQRVRGVLWGTAGAIVLRVVLIAFAVLLLDVPLLKFAGGVLLLWIGVRLMAPAEDAHENVKPADKLWEAVKTIVIADAVMSLDNVIAIAGAAEQADPGHRIALVIFGLLVSIPIIVWGSTLVLKLLDRFPIFITFGAALLGWIAGGLMVNDPAGDRWPLLDTPAAIYGASVAGALFVVIAGYVLKKRRTASSATHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WZ0</accession>
    <name>Q63WZ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204878.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107376.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0749"/>
    <dbReference type="EnsemblBacteria" id="CAH34742">
        <property type="protein sequence ID" value="CAH34742"/>
        <property type="gene ID" value="BPSL0749"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0749"/>
    <dbReference type="eggNOG" id="ENOG5032RUZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="161" mass="17555" checksum="C63D080A23C32D1E" modified="2004-10-25" version="1">MKQTAKVFNSPFELGVRMVFLLLALHPRKADLQTLVYLDYAAIYSADLGGPRSLHTPVPLRNGEYLSRRDVIEQGLYLMSTRGHVSIEVDAGGIWYSAGESATALVGLIAGEYGAVLAERSRWVADTFGSCSASEIEAMFVERGLRWGAHFVDGSSDILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X05</accession>
    <name>Q63X05_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107361.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0735"/>
    <dbReference type="EnsemblBacteria" id="CAH34727">
        <property type="protein sequence ID" value="CAH34727"/>
        <property type="gene ID" value="BPSL0735"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0735"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.806"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CSYRPSD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="21138" checksum="FCD0A4B51B359059" modified="2004-10-25" version="1">MLASSLPLWPAACARNPSAGGMVRRCDDRGCADRPENQASYALRNSGADQENSRLAALEARAKTEPKAAYDLGPRYFRGDGVRRDSDRARRRPSAATCRRGGRSAVLPVRPRAEMGSDAREADKWLSIVAGRGENESKERFEQARADKRAHEEDDKRRTQWRDVYDGYWHSGYPYLGVRRQSDGCWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X31</accession>
    <name>Q63X31_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative aerotaxis sensor receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526156.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107335.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0706"/>
    <dbReference type="EnsemblBacteria" id="CAH34699">
        <property type="protein sequence ID" value="CAH34699"/>
        <property type="gene ID" value="BPSL0706"/>
    </dbReference>
    <dbReference type="GeneID" id="56527083"/>
    <dbReference type="KEGG" id="bps:BPSL0706"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.910"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVFEHMW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="271"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="583" mass="62088" checksum="B8167F8A41EE9F56" modified="2004-10-25" version="1">MRANLPVTQREYDFPDDATLMSTTDPQSYVTYANAAFIQVSGFERDEIIGEPHNFVRHPDMPTEAFADMWATLKAGRSWTAVIKNRRKDGDHYWVRANATPVIRNGQLVGYMSVRTKPSREEIAQADALYRDLREHRARGRKFHQGLVVRTGLFGWMSLLQTMSARWRVRAALLALLAGSAWTAFLFGLHGVMFEGFAATETVLLLLAECWLAAQITAPLQRVLKQSLAVAAGQAGDNVHLNRVDEIGMIMRAVNQAGLNLRSLVDDVSEQLSGLQGASGKIAAGNDDLSGRSEQAAASLEETAASMEQMTATVRNNADTATQAGQLAGSTSAAAEKGDAVVGQVVATMGEISASSRKISEIIGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAAEVRTLAQRSANAAKEIAALIHDSVQKTAAGSALVDQAGDAMNEIRSQVAQVAGLIGEIGSATREQSDGIGQVNVAVTQLDKMTQQNAALVQESASTADELKRRTQRLVDAVAVFRVNARVPARHDDARAPRAGAAAAMRERASVARPRPAMRAAPAPSLALANASTAQAPARATANADADWQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XY9</accession>
    <name>Q63XY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2',3'-cyclic-nucleotide 2'-phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cpdB</name>
        <name evidence="4" type="ordered locus">BPSL0400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.16" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536127.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107026.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0400"/>
    <dbReference type="EnsemblBacteria" id="CAH34388">
        <property type="protein sequence ID" value="CAH34388"/>
        <property type="gene ID" value="BPSL0400"/>
    </dbReference>
    <dbReference type="GeneID" id="56527356"/>
    <dbReference type="KEGG" id="bps:BPSL0400"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1264"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EKAQYPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143881" evidence="2">
        <location>
            <begin position="21"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="467"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="686" mass="72861" checksum="DDEA8C629FD4B7B6" modified="2004-10-25" version="1">MPFPLRFRRRRLAAALVACAALVAGCNDDVDSPGAQSGASAPAGTKATLAVLETTDLHTNVLSYDYFKLAADKSLGFERVATLIAQARAQYPNTLLLDNGDTIQGTALADYQALVKPVSCGETLAIYKVMNAAKFDGGGIGNHEFNYGLPYLSQVTGNAFAVDGLPDPARQKKCAGPDFPQVLANVISAKTNAPLFTPYTILTKNVTATTPDGRTVTAPVKVGIIGFTPPAIMNWDKRWLDGKVYTTGLKEAAEKYIPEMRAKGADLVVAISHGGLDNSPYSPTMENGSWWLSTVPGIDAMLIGHSHQVFPDATSTVAQFNLPGVDKVKGTVNGVPTVMANYWGKHLGVIKLGLAFDGKTWRVDKSQTTVEARSIQNPDKSYVDADPSVAAAIAAEHQATIDYVKTPIGSTDYRMTSYFADVGDPGAIQLVNEAQADYVANYVQTNLPQYASLPVLSVSAPFKSGFGGGTDFTDVAAGALAINNAADLYLYPNTVYAVKVSGADIKNWLETAAKRFNTIDPTKATVQKLVSTFPGYNFDMFTSADLRYEIDVTQPAGSRIRNLAYKGAPIDPNAQFIVATNNYRASGGGNFPGLDGSKTIFASPDANRDVLIAYIKKRGRITRAADGMQRSWRFTKLAGSVAHVQFASAPNLAALASTAGLAGITQVAADDGSGKGLATYEIDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y26</accession>
    <name>Q63Y26_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cutC</name>
        <name evidence="3" type="ordered locus">BPSL0363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522961.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106989.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0363"/>
    <dbReference type="EnsemblBacteria" id="CAH34351">
        <property type="protein sequence ID" value="CAH34351"/>
        <property type="gene ID" value="BPSL0363"/>
    </dbReference>
    <dbReference type="GeneID" id="56527393"/>
    <dbReference type="KEGG" id="bps:BPSL0363"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1307"/>
    <dbReference type="eggNOG" id="COG3142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHRAFDQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="24289" checksum="436A0CF551FD2A27" modified="2004-10-25" version="1">MPASSILLEVIATTIGDARAAARAGADRIELVTAISEGGLTPSVGVIEAVVAAVPIPVNVIVRPHSRSFSYDASELAAIARDVRAAVAAGANGIVFGMLDAHGDIDLDALRRIADAADGRDLTFHRAFDVARDLNAAFDTLLRVPSVTSVLTSGGHPSVLDARDVVARMVRRAAGAACTVLAGAGLTVDALGDFVRATGVRAVHFGSGVRERGEVLAPIDERLVAKARAALDAATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK8</accession>
    <name>Q63YK8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189793.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106807.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0179"/>
    <dbReference type="EnsemblBacteria" id="CAH34166">
        <property type="protein sequence ID" value="CAH34166"/>
        <property type="gene ID" value="BPSL0179"/>
    </dbReference>
    <dbReference type="GeneID" id="56596699"/>
    <dbReference type="KEGG" id="bps:BPSL0179"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1541"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HATVFNK"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03367">
        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="17396" checksum="820F65039B7D851C" modified="2004-10-25" version="1">MLITRKLEFDAGHRIPDHRSQCRNLHGHRYVLEITLRGDLVETEGAPDRGMVMDFADVKALAMEHLVSKWDHAFLVYARDEIVRSFLEKMADHKTVVLDRIPTVENLAAIAFDILANVYDAHYGVNLRLERVRLYETPNCWADVERDPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YL2</accession>
    <name>Q63YL2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106803.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0175"/>
    <dbReference type="EnsemblBacteria" id="CAH34162">
        <property type="protein sequence ID" value="CAH34162"/>
        <property type="gene ID" value="BPSL0175"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0175"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.185"/>
    <dbReference type="eggNOG" id="COG3657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTIKHYL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014056">
        <property type="entry name" value="Addiction_killer_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41791">
        <property type="entry name" value="PTHR41791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028744">
        <property type="entry name" value="Addict_mod_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02683">
        <property type="entry name" value="upstrm_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="11885" checksum="A66AAADD0DB512E8" modified="2004-10-25" version="1">MSLMGYNSRMFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKSTQKKDIKLAKQIAGELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM8</accession>
    <name>Q63YM8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail completion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204760.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106787.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0159"/>
    <dbReference type="EnsemblBacteria" id="CAH34146">
        <property type="protein sequence ID" value="CAH34146"/>
        <property type="gene ID" value="BPSL0159"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0159"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1563"/>
    <dbReference type="eggNOG" id="COG5005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTNRFMK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006522">
        <property type="entry name" value="Phage_virion_morphogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05069">
        <property type="entry name" value="Phage_tail_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01635">
        <property type="entry name" value="tail_comp_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="17536" checksum="5B3DF0EB3CF09DC6" modified="2004-10-25" version="1">MTDDLQALERWAGGLLAKLSPAARRQLLRELGRDLRRAQQSRVAAQRNPDGSAYEPRKVKAGGKRLREKAGRVKREAMFRKLRTARYLRIDVDNTGLAIGFDERLSRIARVHQEGQKAPVEPGGPLAQYPVRVVLGISPNDRELVRDRLIKHLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YU1</accession>
    <name>Q63YU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197759.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106724.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34082">
        <property type="protein sequence ID" value="CAH34082"/>
        <property type="gene ID" value="BPSL0098"/>
    </dbReference>
    <dbReference type="GeneID" id="56596735"/>
    <dbReference type="KEGG" id="bps:BPSL0098"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1633"/>
    <dbReference type="eggNOG" id="COG4681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WIELGQP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009822">
        <property type="entry name" value="YaeQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038590">
        <property type="entry name" value="YaeQ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38784">
        <property type="entry name" value="PTHR38784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07152">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011484">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01322">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="184" mass="20483" checksum="BE7C07A9BFB9B7FD" modified="2004-10-25" version="1">MALKSTIYKAELQIADMDRHYYADHSLTVARHPSETDERMMVRIAAFALFAHERLEFCKGLSDTDEPDLWQKDLTGAIEVWIDVGQPDERRIAKASGRAGRVNVIAYGGRTSDIWWQGARGKVERLRNVQVTTLADGVAAALGGLAERTMRLQCTIQDGAAWLSSATHDPVAIEWTTLKAREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YV7</accession>
    <name>Q63YV7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106708.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0082"/>
    <dbReference type="EnsemblBacteria" id="CAH34066">
        <property type="protein sequence ID" value="CAH34066"/>
        <property type="gene ID" value="BPSL0082"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0082"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.92"/>
    <dbReference type="eggNOG" id="COG4643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDDKDQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009270">
        <property type="entry name" value="DUF927"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014819">
        <property type="entry name" value="PriCT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06048">
        <property type="entry name" value="DUF927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08707">
        <property type="entry name" value="PriCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13362">
        <property type="entry name" value="Toprim_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriCT_2" evidence="3">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="4">
        <location>
            <begin position="222"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF927" evidence="2">
        <location>
            <begin position="369"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="955" mass="103670" checksum="AB5F9EC5272BF7B2" modified="2004-10-25" version="1">MSNAPMSEFERASVALGYVPADDRDTWRQAGMALKAEFGEEGFTLWNEWSQGAQNYNARDARDVWKSFKGGKITINTLFHLAKQGGFDPRAHRAKPVDPAERERQKAERAAREAAELVELIEKQQAASALAESIWSAAEPAPAGHPYLVRKRIPADALRVYRGNLSIGTAACDSALVIPARDADGTLWTLEFILTDGQKRYLLNGRKAGCFSLIGDAVSSVLLIGEGYATCATLAAATGYPVAVAFDTGNLHAVATALRGRYPDARIVVCAYDDHTTNGNPGVTKARAAADAVGGAVAVPDFGPNRPAAGTDFNDLAAHLGPDAVAVAVRAALTSAGSSDADRGKARSPVEKPAKRPKTARAQDGKSRFVVDDKGVWFHGFNNQGDPLPPHWVSTRIDVIAETRNEMNSEWGYLLEFTDRDGILKRWAVPAGLFAGDGTELRRMLLDMGVKLGVTQIARTQIANYVQMAQPDERVRCVPRVGWHHGAFVLPDRVIGTGKEALIYQADTPIQSQFKERGTLDDWQREVAAYCVGNSRLLFCVATAFAGPLLHFSGLQSGGFHLLGTTSKGKSTGGVIAASVFGSPDYVRSWKATDNALEAVATQHSDALLILDEIGQVEPRLVGDVIYMLANESGKARASRSGSAKPVLTWRLLFLSNGEKSVSALMAEGNKPMKGGIEVRLPAIPAEVGEMGVVEKLHGFPTPAALIEHLERHAGMHYGTAGPAFIEWASSQAGELAEHLRVRVDELVGQWVPDGSHSQVARVAKRFCLVAVAGELATAHGLTGWPQGEAVEAARRCFEGWLELRGGTGNSDEAEAVRQVQHFLAAHGDNRFVWMNRAQDDHRPNVPHRAGFKQHVKRDERRTPIGSDREYYAEFGGKMSADDAESVETEYLIEAAVFRKDVCAGFDHKIVAKALMKRGVLMPRSDGYPYRQEYIPGHGKFMVYRVLPSIFTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YX7</accession>
    <name>Q63YX7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524570.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106688.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0063"/>
    <dbReference type="EnsemblBacteria" id="CAH34046">
        <property type="protein sequence ID" value="CAH34046"/>
        <property type="gene ID" value="BPSL0063"/>
    </dbReference>
    <dbReference type="GeneID" id="56527659"/>
    <dbReference type="KEGG" id="bps:BPSL0063"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1677"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFRYMDT"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="10">
        <location>
            <begin position="313"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="494"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="707" mass="74688" checksum="361C15329609C0B3" modified="2004-10-25" version="1">MIDYTLDDDGIATLSWNLPARSQNVLNGESCEAFFAAAARALQDAAVKGMLVTSAKPDFIAGGDLEWLQASDSAETLFARTCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYRVAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGVQASLPLLLEGKRLKAADALAAGILHAVVPAGEEIAAARAWLLDASRRTATQPWDAKGFRIPGGALTHPSVQQVFMAANALARQKTYGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPEAKAMIRTLFFGMNEANKLAARPAGVPTQRYRKVGVLGAGMMGAGIAYVSAKAGLDVVLIDTGEEAAARGKDYSRKLVDKQVQRGRLAREKADALLAKIVPTTDFARLDGAQLVIEAVFEDRAIKADVTRRSEAVLAPDALFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVKTIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDEVSSELIHKITRQTRADLGDAYVARPGEDVAARMVELGRLGRKAGLGYYDYPASGGKKALWPGLAQEFPLAAEQPDVAALIERLVTVQAVETARCLEERVLTTARDADVGAILGWGFPAFRGGPASYIHGVGVDAFVATCDRLAARHGARFAAPALLREMAAQGRSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z29</accession>
    <name>Q63Z29_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
            <shortName evidence="3">T2SS protein E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gspE</name>
        <name evidence="5" type="ordered locus">BPSL0008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533498.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106633.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0008"/>
    <dbReference type="EnsemblBacteria" id="CAH33991">
        <property type="protein sequence ID" value="CAH33991"/>
        <property type="gene ID" value="BPSL0008"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0008"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.8"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RSRIDGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013369">
        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02533">
        <property type="entry name" value="type_II_gspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SP_E" evidence="4">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="497" mass="53834" checksum="B288FE81DAFB930C" modified="2004-10-25" version="1">MTQALAQGAQDQPAAGAPSPIAARLLPYGFAKAGQILIAHQHADTLEVWISERTSSAALAEVARNFGAISLQRMPADELAQAINHAYARQDGSAAQIVGEVEGEVDLSRLMQDIPEVEDLLESEDDAPIIRMINALLTQAAREQASDIHIEPFENASVVRFRVDGTLRDVVRPKKALHGALISRIKIMAQLDIAEKRLPQDGRITLRVGGRPVDVRVSTLPTGHGERAVLRLLEKDAQRLNLEALGMGRDTLMQFDKLISRPHGIVLVTGPTGSGKTTTLYASMSRLETATTNIMTVEDPIEYDLSGIGQTQVNERIGMTFARALRSILRQDPDIIMIGEIRDLETAQIAVQASLTGHLVLATLHTNDAASAVTRLTDMGVEPYLLASSLLGVLAQRLVRQLCPACKEERHEGGRAVWHPVGCDKCGHSGYTGRRGVYELLVIDDSIRSLIHRNAADAEILATGRANGMRTLRDDAERWLAAGATSLEEVLRVTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>H7C747</accession>
    <name>H7C747_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ferritin DPS-family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200519.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109457.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2863"/>
    <dbReference type="EnsemblBacteria" id="CAH36873">
        <property type="protein sequence ID" value="CAH36873"/>
        <property type="gene ID" value="BPSL2863"/>
    </dbReference>
    <dbReference type="GeneID" id="56593722"/>
    <dbReference type="KEGG" id="bps:BPSL2863"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2436"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYLQTHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="18151" checksum="724FFE25889600C9" modified="2012-04-18" version="1">MAKKSNATQINIGISDKDRKKIAAGLSRLLADTYTLYLKTHNFHWNVTGPMFNTLHLMFEEQYNELWLAVDLVAERIRTLGVVAPGTYREFAKLSSIPEADGVPAAEEMIRQLVEGHEAVVRTARAIFPDADAASDEPTADLLTQRLQTHEKTAWMLRSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>H7C755</accession>
    <name>H7C755_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor RpoS</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Sigma S</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sigma-38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpoS</name>
        <name evidence="9" type="ordered locus">BPSL1505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the RNA polymerase core enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193640.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108125.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1505"/>
    <dbReference type="EnsemblBacteria" id="CAH35506">
        <property type="protein sequence ID" value="CAH35506"/>
        <property type="gene ID" value="BPSL1505"/>
    </dbReference>
    <dbReference type="GeneID" id="56595757"/>
    <dbReference type="KEGG" id="bps:BPSL1505"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3541"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00959">
        <property type="entry name" value="Sigma70_RpoS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012761">
        <property type="entry name" value="RNA_pol_sigma_RpoS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02394">
        <property type="entry name" value="rpoS_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="359" mass="40832" checksum="9C8B5AA3AD443A74" modified="2012-04-18" version="1">MPKSKRHDPQAESEKISRAKQASVERTGASADEDEDAADNERDYESRDADPDESGEGRGDAQPDLDDFRALLQAELTADTIQHYLNRISVKPLLTVEEEQRYSRLAKAGEFEARQVMIERNLRLVVSIAKGYLNRGVPLLDLIEEGNLGLMHAIEKFDPTRGFRFSTYATWWIRQSIERAIMNQARTVRLPVHVIRELNQVLRAKRHLEKNSMSTGEAAERREASIDDIAYLTGKTAEEVTDILALNEHTASLDAPLDLDPASSLLDLLPDDQSQSPDAEVQHRELETLTRAWLSRLSDKHRHVIERRFGLNHIEPATLEELADEMGLTRERVRQIQQEALVRLKRFFASNGVRKDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>H7C769</accession>
    <name>H7C769_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192042.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108790.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2195"/>
    <dbReference type="EnsemblBacteria" id="CAH36197">
        <property type="protein sequence ID" value="CAH36197"/>
        <property type="gene ID" value="BPSL2195"/>
    </dbReference>
    <dbReference type="GeneID" id="56595978"/>
    <dbReference type="KEGG" id="bps:BPSL2195"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3253"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QQAAWIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="166"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="287" mass="31232" checksum="A7352D248252731C" modified="2012-04-18" version="1">MSPSVPLFAQPPAATIDVPSEFAPTRSHPMRVRARAIAAGMRVPPHAHAWAQLAYASRGVLRLATAGSTWMVPPSRAIWVPPRIAHEVVIVEDAYLRTLYVDESAVPGGLDACRVVEVSGLLRELIVALEARSLNRTRERLLAELVLDELTRAEPLPLAVPMPTEKRLRALCEAVLAHPAQGESLEHWAAGVGASTRTIARLFKQELGVSFSQWRQQALLARAIPLLNQGRPLSHIANELGYQSQSAFSAMFRRAFGASPRAFIQRGDMHAASELASTDDGDAEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HS7</accession>
    <name>Q63HS7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112345.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2343"/>
    <dbReference type="EnsemblBacteria" id="CAH39829">
        <property type="protein sequence ID" value="CAH39829"/>
        <property type="gene ID" value="BPSS2343"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2343"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6804"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRAHLVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="203" mass="21770" checksum="A839182BDD797CF2" modified="2004-10-25" version="1">MLTAEQRDALQEIANLAMGRAAARLALLLGAFIELSVPRVRVVRAADVGRVLRDMTGIHDNVTAVRQGFRSDIKGEALMLCRSAGVGQLVSLVDGAYADDEFGTVTQAELVFDMANVLMGACVSSILDELGRTPVFSPPGLLGEDIALDDVFQPDVLAWSETLLLEVNFGVADDGARTHFVMLLAEDSIRHMSDALDLLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV5</accession>
    <name>Q63HV5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188734.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112317.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2315"/>
    <dbReference type="EnsemblBacteria" id="CAH39801">
        <property type="protein sequence ID" value="CAH39801"/>
        <property type="gene ID" value="BPSS2315"/>
    </dbReference>
    <dbReference type="GeneID" id="56598424"/>
    <dbReference type="KEGG" id="bps:BPSS2315"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5948"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HPMWRDG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="23177" checksum="ED251FDA6588351D" modified="2004-10-25" version="1">MTPASSTPRTARLLLVDDHPLVRDGLKMRLEAAPGLAVVGEAGNADEALTLAEALAPDLALMDIGMQGMNGIALAGVFHERFPAIRVLMLSMHDNVEYVTQAVRAGASGYLLKDSPATEIVRAIGAVLAGQTFFSEGIAARMIHASAEASPLDRLTPRERDILDALAQGLSSKQIAQRNGLSVRTVETHRLNLKRKLDIEGQAELIKFAVEHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HW8</accession>
    <name>Q63HW8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188558.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112304.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2301"/>
    <dbReference type="EnsemblBacteria" id="CAH39787">
        <property type="protein sequence ID" value="CAH39787"/>
        <property type="gene ID" value="BPSS2301"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2301"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5923"/>
    <dbReference type="eggNOG" id="COG3302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HPQNLYY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019645">
        <property type="term" value="P:anaerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007059">
        <property type="entry name" value="DmsC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38095">
        <property type="entry name" value="PTHR38095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04976">
        <property type="entry name" value="DmsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="316" mass="33503" checksum="813FD45CF98A9E51" modified="2004-10-25" version="1">MKPAFSVIFLTTLSGASQGLMIALFGVELAARLGWIASPPQAFFVASAALAVLLGSLGLFASFFHLGRPERAWRAVAMWRTSWLARECIALPCFLACTTAYGGAHWLALPHTLALGLLAAVASGALFVCTGMIYICLRFLQEWATPLTMTNFVLLGCASGGTLATAGAAWFAPPLVPALAACACALTLAGGAARVASLARNARLRPRSTVQSATGIRAQQVVQRSRGFTAGAFNLREFFHGKTPQTLRRVKWTFLICAFAVPFALLAIGGATAPAVMSFALACGAFAIQYAGLVAERWFFFAEARHPQNVYYQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ8</accession>
    <name>Q63HZ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bkdB</name>
        <name evidence="8" type="ordered locus">BPSS2271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532554.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112274.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2271"/>
    <dbReference type="EnsemblBacteria" id="CAH39757">
        <property type="protein sequence ID" value="CAH39757"/>
        <property type="gene ID" value="BPSS2271"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2271"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5881"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HPCIMAP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="483" mass="51540" checksum="5F727BD71DD588D1" modified="2004-10-25" version="1">MGVHVIKMPDIGEGIAEVELGLWHVKVGDRVKEDQAIADVMTDKASVEIPSPVTGVVVALGGKEGDVLAVGSELVRLEVEGDGNHKAEPDGGARAAAAQPERVADTAHAHASAAAKSARGEHGAGHGRDDARAASSGTSSGASHTQHAEREARGHRESSEYREDRSVSRGASQTDVERGPASPPPARRPGERPLASPAVRKRAWDLGVELRYVHGTGEAGRILHEDLDAYLQGRGAAAQRARGGQAAYVERHDEEAVPVIGLRRKIAQRMQDAKRRIPHFSYVEEIDVTELEALRAELNRKYGDTRGRLTVLPLLARAMVIALREFPQINARYDDEAGVVTRHGAVHLGIATQSKAGLMVPVVRHAEARDPWSIAAEVARLADAARAGRAERDELSGSTITITSLGALGGIASTPVINSPEVGIVGVNRIVERPMFRGGAVVARKLMNLSSSFDHRVIDGMDAAEFIQAVRGLLEQPALLFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I12</accession>
    <name>Q63I12_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187868.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112260.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2257"/>
    <dbReference type="EnsemblBacteria" id="CAH39743">
        <property type="protein sequence ID" value="CAH39743"/>
        <property type="gene ID" value="BPSS2257"/>
    </dbReference>
    <dbReference type="GeneID" id="56598365"/>
    <dbReference type="KEGG" id="bps:BPSS2257"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5860"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SMRYELP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="26222" checksum="A20B58D73624F469" modified="2004-10-25" version="1">MSQLSSDPISGASLAGRTAFVTGGGRGLGAAICGELARAGAHVVVADLDEARARGVAERLARDGARAVPLGVDVGDETSVRHAFDAARESLGDIDVIVNNAAIDVTAAIDDVSVDAWRQVLTTNLFGPYLLCHAAVPMMKARGRGHIVNIASTAAKRAWPNASAYHATKWGLLGLSHALHAELRPSGVHVSAIVAGGMRTPFLLDRFPDIDADTLQPPEHVAAAVRFVLTQPPGTVIPEVMVLPVKETSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I40</accession>
    <name>Q63I40_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523329.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112232.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2229"/>
    <dbReference type="EnsemblBacteria" id="CAH39715">
        <property type="protein sequence ID" value="CAH39715"/>
        <property type="gene ID" value="BPSS2229"/>
    </dbReference>
    <dbReference type="GeneID" id="56531680"/>
    <dbReference type="KEGG" id="bps:BPSS2229"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5826"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGICELC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="143" mass="15768" checksum="1293969F8D869685" modified="2004-10-25" version="1">MQRINEIMSRDVVHVAPSDSIRHAAELMARFDIGALPVCQNSRLIGMITDRDLAVRAVSAGKAPDTKVHEIASGPIEWCFDDDQVDNVQKYMADAQVRRMPVVDHDKRLVGMLSIGDIATRTDGASRDEVANTLEGVSQPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IB3</accession>
    <name>Q63IB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188578.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112159.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2158"/>
    <dbReference type="EnsemblBacteria" id="CAH39642">
        <property type="protein sequence ID" value="CAH39642"/>
        <property type="gene ID" value="BPSS2158"/>
    </dbReference>
    <dbReference type="GeneID" id="56598328"/>
    <dbReference type="KEGG" id="bps:BPSS2158"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5730"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TIMRLCI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="249" mass="26587" checksum="CF595F2476438146" modified="2004-10-25" version="1">MTNQTDGGVAAVNRALAALVAFGEAPGGLTLAQVSEASGVNMSTLLRMFESLERFRFIKRLNDGRYVLGPAVFQLGMMYRESFQLREHVMPVLDALGAETGETTAFYVREGDQRVCLFRVHPRRAVRTYLREGDRYPLDVGAAGRVLLAFSGARGGSFDKTAAQGYAVSLGERDPDSAAIACPVFGVGRALIGALSLGVPRFRFNKKVQADYLPRVQAAANALTHALGGDLPPAAGVAQVVDLFGAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC6</accession>
    <name>Q63IC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-05" db="PDB data bank">
            <title>Crystal structure of Putative exported protein (BPSS2145) from Burkholderia pseudomallei K96243.</title>
            <authorList>
                <person name="Abendroth J."/>
                <person name="Dranow D.M."/>
                <person name="Lorimer D.D."/>
                <person name="Horanyi P.S."/>
                <person name="Edwards T.E."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 34-563</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552217.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112146.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="6OZD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.55 A"/>
        <property type="chains" value="A/B=34-563"/>
    </dbReference>
    <dbReference type="PDBsum" id="6OZD"/>
    <dbReference type="SMR" id="Q63IC6"/>
    <dbReference type="STRING" id="272560.BPSS2145"/>
    <dbReference type="EnsemblBacteria" id="CAH39628">
        <property type="protein sequence ID" value="CAH39628"/>
        <property type="gene ID" value="BPSS2145"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2145"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5714"/>
    <dbReference type="eggNOG" id="COG4632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRVPGLI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266459" evidence="1">
        <location>
            <begin position="30"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="2">
        <location>
            <begin position="80"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6OZD"/>
        </source>
    </evidence>
    <sequence length="563" mass="56614" checksum="8BFF7D7EB618473A" modified="2004-10-25" version="1">MRTTKSPGISVIRQRLAVALPLALTLTLASCGGDDLTPAAQRWAMPGTELPLGPQGLAQSVSTQTLAAGVAYYQIKRGAASAADFWTVNLGFYATQAAAQADAANLAAAGFATRVDASAGTDLQGKVLGYWLSAGRYATQAEATAAAARIAQATQNRYKPGTRHTSLAGAPTTGPWIVNVLAIDPSRAGAALSLALPGGNDLGAGGETVSAARARVNALAGVNGGFFTNINPFGAPLPPRSPVGATVVDGRLVAAAIGRRPGLLLARDANGRQRATVVRNLATAITLTDAQGRAIAVQTLNRPILGTVVNCGAQARTPTSEPAQDTVCTNYDDLVMYDSLYLRGGASNTLVDAGYQGARYELVVDANGAVVAGHATLGAPPPPNGYVLQGLGASAAWLQAHATPGTRLAVSRRLSADGADLALASGTSLVEAGPTLSVPNLAQSAAQEGFAPTVGGVDAGEGAAANGNWYNGWYVARNGRTAAGVAADGTILLVEIDGRQPTLSVGTSIPETAAVMAWLGATSAVNLDGGGSSNMVVGGKMVGHPSDAVGERGVGDTLMLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG0</accession>
    <name>Q63IG0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase/short-chain dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524799.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112112.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2114"/>
    <dbReference type="EnsemblBacteria" id="CAH39594">
        <property type="protein sequence ID" value="CAH39594"/>
        <property type="gene ID" value="BPSS2114"/>
    </dbReference>
    <dbReference type="GeneID" id="56531791"/>
    <dbReference type="KEGG" id="bps:BPSS2114"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5660"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPETPEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="24493" checksum="40F59AE651C536B6" modified="2004-10-25" version="1">MAVEKVALITAAGKGMGAAIARELASAGYRVALMSPSGSAVALAGELDGLGLRGSVTEEADLDRLVRETLARYGRIDAVVNNTGHPPKGELLSIADASWHDALDLILLNVARLMRRVTPVFQAQGGGAAVNISSFAAVAPEQPMPVSSVLRAALGAWTRLYAERYAAENIRMNAVLPGFVDSWPETPGIVARIPAGRFGRTREIAKTVAFLLSDGAGYVTGQSIRVDGGIVRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IL6</accession>
    <name>Q63IL6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6531 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112056.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2054"/>
    <dbReference type="EnsemblBacteria" id="CAH39532">
        <property type="protein sequence ID" value="CAH39532"/>
        <property type="gene ID" value="BPSS2054"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2054"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5594"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LNYNRHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="1">
        <location>
            <begin position="275"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1543" mass="170462" checksum="B9666C57D7FE8D1B" modified="2004-10-25" version="1">MALPAVKHLDPVVGIDVHSVLVTPGTPPVFLPHPYVGFMLDRREYIDAALGVIGSIVFTFTPLGKEADAGLKWAKKQAKAELMSDPLIAEGVKLGKEAAPVAGDIAGAVGAGVGMGSMMGRPIFVNGFLRATAGTHSFHVPGLHFPLGESFAPPPEDFEPSNDGESYMGSRTVLANNDPMSFMALPAMSCWSVGLEPPPHNGAHTQRTALSMPSSVMLPIPVGRPVLVGGPPVMNMAALASSLFKAFRGSDWAKALADKLHLKPGFLRCNVLRAEPVDAITGEVVVQQHDFTVPGRLPLVWNRYYTSHDTYVGAVGIGWQTPADIRLELTRHEGAVGVVAYFPDHATAFDAIPDAAGWPARVYDWQHGQALYRQDDRLVLRTRAGFEYEFALPAHWQHALERLAEDATLTLPVERMADLNGNAWVFERGLDSSLTRLVEWKAEEATGRMIACAASASSRAGDHVSLLTALTLIDAGGRAHPLVSYQHDRNVDLVAAIDAMGQPHRYAYTDGHRMISHTSARGISFYYSHRRHDDGVWRVDHAWGDNGLFDYRFIYDPARHETRITDSLGHTTLLQSDERGMPVARIDPLGGVTSYRYDAQGRTNAETDPAGRTTAWEYDTFANLLMRTLPDGTALRTEYNTGHKPVCVAVPGGGQWRYTWDERGNLLMQTTPSQASVRYAYDQYGQLIAHTGPRGTVTRFDYDRSGLLAVRTDALGHRTQYTHDALGNLVHVINALGQTSRYEYDNIGNLTRAIEPGGREVHCVYDADGNLVRYRDATGNVTQLVYTALGHISKRQTPDGNVVEYRYDTEEQLVGVVNGRGEIYEIKRDELGRIVEETDYWGQPRHYRYGAAGELLDITDPLGQTIEYRCDRLGRVVEKRMPDPLHPDGVRIDRFVYDQHGDLVLAENPSSRVEFRYDADGRVIAERQGDDFTIASTYDASGNRTERKTRLVADSDVVEHTVRYEYDALDAVIAIQIDDAAPIVLERDAVGQVCVEQLSPELRRELSYEAGGQLAKQTLLGGTGLLFASEYAYDANDELVEKRDSRTGVERFKYDPVGRIVAHTDPTGRLRSYVYDPAGDLLKTHIHERRTAGATEMTQTGTWVREGEFEGHYHAYDRAGNLIRRQDVGQDLTLRWDAAGQLAEAVAVRPAIAGAGGGQVRIGTQYEYDAFRRRVGKLVLTRAAGSAELVLSRISRFFWDGNTLVGQCTRGGGEGGGTAIPDAGDRMPAAQFIPVRDNRDDAPVSGFEHAYEWVYYPGMFRPLAVVHCDLAATRASVPTTTNLLPLIGAVYFFQSDLNGAPVQMHAPGGRVVWEARYDPIGRSEQLGLQLVEQPVRLQGQYFDAETGLNYNRHRYFDPNSGIFISQDPIRLSGGLNLYQYAPETNNWIDPLGCSGHRRRHEKMPPEGARLTTGNLFRHAQDEGISPILSSKNDEFYYRLIKIYAGTGMLNANIRGIASHVEPKAGLILNEDGSGWKIGSLYINYPNGPCLDCRTLMPFILNDGSILYVTFPTLGLDGYSYGHFHGREPGFFREGTPCNLPHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IN3</accession>
    <name>Q63IN3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AMP-binding acetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556345.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112039.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2036"/>
    <dbReference type="EnsemblBacteria" id="CAH39514">
        <property type="protein sequence ID" value="CAH39514"/>
        <property type="gene ID" value="BPSS2036"/>
    </dbReference>
    <dbReference type="GeneID" id="56531844"/>
    <dbReference type="KEGG" id="bps:BPSS2036"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5566"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRIWTKF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="434"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="553" mass="60711" checksum="57FD8E8446EACC1B" modified="2004-10-25" version="1">MTSIAPENLPLERLQHWERARADDVWLVQPGADGGVRRFTWRDAVEEARRVAAYLRALDLPRGSNIAILSKNCAHWVLADFAIWLSGHVSVPLYPTLGAESIRQVLTHCEAAALFVGKLDAWETMRAGVPPHVRSIGLPYLHDASSVGATWDDIVRDTAPLAEHVTRAADALATIVYTSGTTGEPKGVMLTFGALGWCVEPVFDLVAIGPDDRMISYLPLSHVAERGYVEMLSVRAGFTVYFSDSPDTFIADLQRARPTFFISVPRLWAKFRHAVASRLPPGPVPDAMKPMILRQLGLDQVRLAASAAAAIEPALLRWYRDLGLELLEGYGMSEVCGVSHSCRQHDMRLGYVGTPVRDVESRLADTGEIEIRSPGNTIGYYKRPDLSAALFTPDGFVRSGDKGELDEAGRLKITGRVKEIFKTSKGKYVAPSPIESRLATHPFVDACCVVGSGLAQPCALVSLSDEGRRFDGDGRRAALETSLGEHLAHVNASLDDHEKLRFVVVVDSVWNETSGFVTPTFKVRRNRVEARYAPFLDAWDARGATIVWESDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IR1</accession>
    <name>Q63IR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552141.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112011.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2007"/>
    <dbReference type="EnsemblBacteria" id="CAH39485">
        <property type="protein sequence ID" value="CAH39485"/>
        <property type="gene ID" value="BPSS2007"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2007"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5525"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QHGLQRN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="42391" checksum="9250DC4845A2C9FF" modified="2004-10-25" version="1">MSLFTTACAKILPRRLHSVIRRRRSWNVPLVATCVAMSTSSCVQHADVVAEAQRLNAPVKAVADQRVPVDTPHGDGLLPVYANLPIDKPEPSVKRVFIVMHGTLRNADVYFASGRQIVERAGDLGKDVMVVAPQFLTQSDTRAFSLSEETLAWTQEGWKGGEAARQPGPISSFAALDALLAHFANRALYPSLSAVVMMGHSAGAQLLQRYAVAGREGEKLARDGISVRYIVANPSSYLYFDDERPNGEVTAGGACPAATEWKYGLKSAPPYVVSQDLQDLESRYVRRSVVYLLGEADTDPYTHFIDRSCAAMAQGPYRLARGLAYFDYLKKRHPSDLAHRVVEVPGVGHDNLRMFTSDCGLAVLFDKATPQSCPIFTASAPSVRAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JE7</accession>
    <name>Q63JE7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
            <ecNumber evidence="3">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndh</name>
        <name evidence="3" type="ordered locus">BPSS1769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190401.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111775.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1769"/>
    <dbReference type="EnsemblBacteria" id="CAH39244">
        <property type="protein sequence ID" value="CAH39244"/>
        <property type="gene ID" value="BPSS1769"/>
    </dbReference>
    <dbReference type="GeneID" id="56598197"/>
    <dbReference type="KEGG" id="bps:BPSS1769"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5201"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="460" mass="49975" checksum="05639BC28DAE128E" modified="2004-10-25" version="1">MHRFIIVGGGAGGLELATRLGDRYGARGDRPARALVTLVDRYPTHIWKPLLHEVAAGSMDPFTQELEYAAQARWHGFEFHQGELIALDRASRRVTLAPVADNDGAELLPLRELEYDTLVIAIGSTTHYFGVQGAQQHSIALDTVAEAERFRKRLIAACMRAEHQPAEPAVRTAEGGPEQAVEPTDAAQVSASPRIQVAIVGGGATGVELSAELRNTAQVLSAYGLHKLDPRHDVGIVLIESGPRILPALQERVSTATAELLEKLGVRLLLGERVTEVAPGVVRTASGKSVRADLTVWAAGIKAPSVLAKLDGLEVNKLGQLAVRRTLQTETDPDVFAFGDCAGCEWPGHERNVPPRAQAAHQQASFMLRALANRLEGRPLPEFTYRDFGSLVSLGHFSAVGNLMGGLIGGNMLIEGLFARFMYMSLYRLHIAALHGYPRMVLDTVAHWLRRSTLPRVKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JH6</accession>
    <name>Q63JH6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipase chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lipase activator protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipase foldase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipase helper protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipase modulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lipB</name>
        <name evidence="8" type="synonym">lifO</name>
        <name evidence="9" type="ordered locus">BPSS1740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in the folding of the extracellular lipase during its passage through the periplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lipase chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205672.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111746.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1740"/>
    <dbReference type="EnsemblBacteria" id="CAH39215">
        <property type="protein sequence ID" value="CAH39215"/>
        <property type="gene ID" value="BPSS1740"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1740"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5166"/>
    <dbReference type="eggNOG" id="COG5380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QQYIDYK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00790">
        <property type="entry name" value="Lipase_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004961">
        <property type="entry name" value="Lipase_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03280">
        <property type="entry name" value="Lipase_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="344" mass="36616" checksum="53FBCC4B65F012AE" modified="2004-10-25" version="1">MKGEGSVARRVALYCVAGAVAAGAVWYVVGAPAKRDAGASPASPELAASAPVAVAARADAGSAASGLPASLAGSSAPRLPLDAHGHLAKARAVRDFFDYCLSAQSELSAQALDALVTREIAAQLDGTLAQGEALDVWKRYRAYLDQLAQLPDGGAPGNKLDLAALQLALDQRASIASRALGDWAEPFFGAEQQRQRYDLARLRIVRDASLTDAQKAARLAALEQQLPLDQRAEQAREKQQNDAVARIAQLQKSGASPDEMRAQLAQSLGPEVAERVAKMQQANDAWRAKYDEYAAQRAQIDAQHLSPQDRDTQIAQLRQRYFTQPGEALRAASLDRGGAATQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K36</accession>
    <name>Q63K36_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative HNS-like regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bprA</name>
        <name evidence="7" type="ordered locus">BPSS1530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187356.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111536.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1530"/>
    <dbReference type="EnsemblBacteria" id="CAH39003">
        <property type="protein sequence ID" value="CAH39003"/>
        <property type="gene ID" value="BPSS1530"/>
    </dbReference>
    <dbReference type="GeneID" id="56597875"/>
    <dbReference type="KEGG" id="bps:BPSS1530"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4885"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PAWIKDK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="6">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10910" checksum="8495F3223BDDC807" modified="2004-10-25" version="1">MATYKELKARAEALSAQAEAARQAELQAAIEDVRAKVREYGLTAYDVFGHRKKPGERHRGAVRPKYRDPATGATWTGRGIEPKWIRGRNRDEFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KI1</accession>
    <name>Q63KI1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111391.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1380"/>
    <dbReference type="EnsemblBacteria" id="CAH38852">
        <property type="protein sequence ID" value="CAH38852"/>
        <property type="gene ID" value="BPSS1380"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1380"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5610"/>
    <dbReference type="eggNOG" id="ENOG5030DAG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CDWLDRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10717" checksum="AF7E7C58CF87C1EE" modified="2004-10-25" version="1">MTARVRTGRWLPTERLVAAVRAWLACHGMHCEWHDRIRIAIASTEFAHGIYAASAGGDASRFAPRFGERMATDALEPPMQALRARCDALLQRLGRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KK9</accession>
    <name>BETI_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH-type transcriptional regulator BetI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">betI</name>
        <name type="ordered locus">BPSS1353</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine.</text>
    </comment>
    <comment type="pathway">
        <text>Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway [regulation].</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202513.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111363.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63KK9"/>
    <dbReference type="SMR" id="Q63KK9"/>
    <dbReference type="STRING" id="272560.BPSS1353"/>
    <dbReference type="EnsemblBacteria" id="CAH38824">
        <property type="protein sequence ID" value="CAH38824"/>
        <property type="gene ID" value="BPSS1353"/>
    </dbReference>
    <dbReference type="GeneID" id="56597558"/>
    <dbReference type="KEGG" id="bps:BPSS1353"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4657"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLAFYAE"/>
    <dbReference type="UniPathway" id="UPA00529"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00768">
        <property type="entry name" value="HTH_type_BetI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017757">
        <property type="entry name" value="Tscrpt_rep_BetI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03384">
        <property type="entry name" value="betaine_BetI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000257730" description="HTH-type transcriptional regulator BetI">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00768"/>
        </source>
    </evidence>
    <sequence length="195" mass="21490" checksum="8C55556202909360" modified="2004-10-25" version="1">MPKLGMREIRRAQLIDATLRSIDEAGLPGTTLASVAQRANISTGIVSHYFGDKDGLLEATMRHVLRDLWAATTRRRAAASDAPRARLRAVVAANFDDTQISAPVMKTWLAFWSQSMHEPTLRRLQRVNTRRLHSNLCAEFAKTLPRARAREAASGLAALIDGLWLRGALAGEPLDTKAALKLANDYIDQLLAPRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L73</accession>
    <name>THIM_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="1">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="1">TH kinase</shortName>
            <shortName evidence="1">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiM</name>
        <name type="ordered locus">BPSS1135</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004542754.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111148.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63L73"/>
    <dbReference type="SMR" id="Q63L73"/>
    <dbReference type="STRING" id="272560.BPSS1135"/>
    <dbReference type="EnsemblBacteria" id="CAH38603">
        <property type="protein sequence ID" value="CAH38603"/>
        <property type="gene ID" value="BPSS1135"/>
    </dbReference>
    <dbReference type="GeneID" id="56530451"/>
    <dbReference type="KEGG" id="bps:BPSS1135"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4354"/>
    <dbReference type="eggNOG" id="COG2145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRPLVHN"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000383826" description="Hydroxyethylthiazole kinase">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <sequence length="276" mass="27510" checksum="1F7B2E4B381E6D6E" modified="2004-10-25" version="1">MESISWNTPSVRDALAAVKRDAPFVYGLTNYVAANLSANVLLAVGAAPAIGAAADWPARFGAGANALWINTAALMSSGADTLLTAARAASKAGTRWVLDPVALGAGAPEYDAIVRDLLALRPTVIRGNASELIALAGGTAAGKGVDTTASPESALAFIGDLARRSGAVVAVSGPTDYVTDGVATLAVAGGDARLTRVTGAGCALGALIAALLAQRGAALAAASAAHAIYATAAERAADARGTASFAVRFVDELSLLDPAESSRDRSAGQIGAKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L86</accession>
    <name>Q63L86_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative WD-repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549832.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111135.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1122"/>
    <dbReference type="EnsemblBacteria" id="CAH38590">
        <property type="protein sequence ID" value="CAH38590"/>
        <property type="gene ID" value="BPSS1122"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1122"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4340"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVWDANL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="565" mass="60951" checksum="2BF3F1B4B92399E1" modified="2004-10-25" version="1">MITHRAPISGIAAHRDQYVLTAGYDNQVILWDAKTQRPLARAMHDHLANQGAFSPDGAYVVTSSSDYSARLWTVPDLRLVAVFADQEDDVEMSVFHPDKPLVATASRDHRVRVYDFGGKLLHTFSGHTADVISVEWMRGADEIVSSSDDGTIKRWSLANNGLVADIDLDGIETDTIAIAADGRIFAGNDEGEIISIGVDGARATIAAHDAGVKRLVLDGERGLLVSLSYDRTMRLWKAGAAGEPRALGGAALPPEVWPRSCSFEGDEHIVFSTFHSSYRRYNWKTERWDAAELPPTHGVNAVQPVDGHLWTIGDAGIVRVDQREHARTGSLCNFLAPAGELILTGGQLGKVFDARSGRELHQHRSPLNCGVAFARDGAAHAVIGTYTGEGIVLRIDGTRATHVADLPLHANAVKGIAISGDLIFSVAADASATWYRASTLEPAFELKRAHDKIANGCAGLGDGYFASVSRDLKLRIWSPDSHAEVIATPHTHSIKCVAASADGRYVATGSYNGRVAVYDRVETRWALDARVTTAGVSSLAYDPAARAFLASSYDGNVYRIPLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L88</accession>
    <name>Q63L88_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205543.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111133.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63L88"/>
    <dbReference type="STRING" id="272560.BPSS1120"/>
    <dbReference type="EnsemblBacteria" id="CAH38588">
        <property type="protein sequence ID" value="CAH38588"/>
        <property type="gene ID" value="BPSS1120"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1120"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4337"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NYEQSYA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001442433" evidence="2">
        <location>
            <begin position="23"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="512" mass="54435" checksum="326A8373C507EAC8" modified="2004-10-25" version="1">MRTAVRAAAVAAAFFAAGCTLAPRYERPAAPVSGAFPADGVYAAQPGAAPGARSANGQAAVDIGWREFFVDPRLQRLIEIALKNNRDLRVSVLNVEASRAQYQITRAGLFPTLSGTGTGTIQRTPAGVSITGQPLISRTYNVGVSASWELDLFGRVQSLKDQALAQYFATAQARKAAEISLVASVADQYLTLLSTDDLLQVTQNTLKSARASYDLTKLQFDNGTGSELDLRQAQTVVETALASQQAQARARAQALNALVLLIGEPLPDDLPAGLPLNAQNLLTDIPAGLPSDLLTRRPDIMQAEETLRAANANIGAARAAFFPKISLTSAFGTASPTLGGLFKAGTAAWSFAPNIALPIFEGGQNIANLDLAHVQKRIEIANYEKAIQSAFREVSDGLAARGTYDQQIAALERNEHAQQRRYDLSDLRYRNGVDSYLSVLTAQTDLYSAQQQLISARLARWTNLVDLYRALGGGWLERAGETPRPADAPVDYGKAAPAPAASASARTAAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LE3</accession>
    <name>Q63LE3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage head completion/stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531050.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111078.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1067"/>
    <dbReference type="EnsemblBacteria" id="CAH38533">
        <property type="protein sequence ID" value="CAH38533"/>
        <property type="gene ID" value="BPSS1067"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1067"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4264"/>
    <dbReference type="eggNOG" id="ENOG5032SDV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRWSVAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009225">
        <property type="entry name" value="Phage_head_completion_GpL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05926">
        <property type="entry name" value="Phage_GPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="17000" checksum="73C328EF401F82C5" modified="2004-10-25" version="1">MNSFVATAAPAVAATPIEGTLTNDGFFPDIDLSALRDAMRLDGTVTAERLRHAARDALLTVNDELAAWRARQRAAGAATLADVPAPRIDGESAHVARYRRAVYHLTHADVTEKYRGYDTTKSGGQVAADLAATVDDARRAARWAISDILGVARSTVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LK9</accession>
    <name>Q63LK9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSS1006</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111012.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1006"/>
    <dbReference type="EnsemblBacteria" id="CAH38467">
        <property type="protein sequence ID" value="CAH38467"/>
        <property type="gene ID" value="BPSS1006"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1006"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5133"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITGLEWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
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        <property type="term" value="F:N-acetyltransferase activity"/>
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    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
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        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
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    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
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        <property type="entry name" value="ACP-like_sf"/>
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    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
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    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
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    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
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    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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        <property type="entry name" value="PKS_dehydratase"/>
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        <property type="entry name" value="PKS_dehydratase_sf"/>
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        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
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    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
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    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
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    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="412"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="665"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="622"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2300"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3765"/>
            <end position="3817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3977"/>
            <end position="4024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="3765"/>
            <end position="3787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="3799"/>
            <end position="3817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="3977"/>
            <end position="4005"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="12">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH38467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="4574" mass="484884" checksum="F8FA0909D2D9C75F" modified="2004-10-25" version="1">[encoded data, 4574 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M01</accession>
    <name>Q63M01_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539065.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110870.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0860"/>
    <dbReference type="EnsemblBacteria" id="CAH38322">
        <property type="protein sequence ID" value="CAH38322"/>
        <property type="gene ID" value="BPSS0860"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0860"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7147"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TLEWQRD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="253"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="507" mass="52156" checksum="ACA064725B1E0236" modified="2004-10-25" version="1">MAITQTGTTSQSDVWSQIQDAAQSLINGATGKTSMDVSGLVSVLVNAKTAGQAAEIKNQAAWNSTQISALGALKLALSNLKTGVEPLSDGTFAQKFTSKASGKGLGATMDKGTVAGSYQVEVKQVARSQTLVSAGFDPKHTLGSGTLTLKLGDRSTSIDIDATNNTPAGIAAAINSAKNNPGVTATVVTGTDGAHLVLRSTASGSANVISMSVSNLKDDAGLSGLAVQSTADDKGGKSAITSAGDAWKQSDFAQDAIVTVGGVITARSADNAVKGVIAGVTINVTEEAIGAPQTLSIARDIDGQARAVTNFVDLYNSMIGTMAQLTSFDKTAKPGQQGGPMIGDSMLNGIRNSLAHIVGGGVPHGENKRASLAALGITFARPGDKQPEGSLIVDKAKLNEALQNDPQAVEALFNKTNGIGTQITKALDVHLRKDGSFDVRSNAIDRDMKSIAQRQARLETYASQLTAQYKAQFTALDALMARMQQNTNYLTQLFGGANSSGALANNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M36</accession>
    <name>Q63M36_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531698.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110835.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0824"/>
    <dbReference type="EnsemblBacteria" id="CAH38286">
        <property type="protein sequence ID" value="CAH38286"/>
        <property type="gene ID" value="BPSS0824"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0824"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7095"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TEFANSY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="32928" checksum="9B007AFE7ED4A8F4" modified="2004-10-25" version="1">MSDGPALGIRPLSAALGARIDGIDARAELDADTVRAIRAAWLRFGLLVFRGQALDPPRLVAFTRRFGEPVVYTRACNACDGQPEVLVLSNVVKDGKPIGAALSGRYWHTDGHYLACPPAGTLLFGAEIPAVGGDTHFVNMTAAYRALPAWVRTQIDGRTFVMDRVQTLPFHYPQRPAPPPDQKQAWPDMPQPVVRTHPETGENALYIGGVVPWRIVGMEQGLSDALMAHLHAIAFDEARFGYRHRWRAGDLLMWDNRCLAHRATDYDMVRHRRTMYRTTIAGDRPRYVRGAAQPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ME8</accession>
    <name>Q63ME8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205452.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110723.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38169">
        <property type="protein sequence ID" value="CAH38169"/>
        <property type="gene ID" value="BPSS0709"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0709"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6926"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSWINIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="2">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="3">
        <location>
            <begin position="325"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="487" mass="56072" checksum="9C6C7444DC1FCE0D" modified="2004-10-25" version="1">MLKTPMPTQHELEMVTLEELVPKDHLLRQIDATVDFEFIRAKVAHLYCADNGRPALDPVVMFKLLFIGYLFGVRSERQLMREVQVNVAYRWFARFRLTDKVPDASTFSQNRRRRFTDTTVYQEIFDEIVRQAIKRGLVDGRVLYTDSTHLKANANKGKFDVVKLEQTPAAYTEALNAAVDADRAAHGRKPLDRDDDEPPSSKDTKLSRTDPDSGYMVRDDKPKGFFYLDHRTVDAKHAIITDTHVTPASVHDSQPYLDRLDRQRERFEFKVEAVGLDAGYFTPAVCQGLEERGIAGVMGYRTPNHKPGMFYKRQFKYDAYRNEYVCPQGQALPYSTTNRLGYREYKSNAQICGRCPVRSQCTNSAIAVKVVTRHVWERAKERVDARRLTEWGQRIYARRKQTVERSFADAKQLHGHRYARMRGLRKVAEQCLLAAAAQNIKKIAMLLARKRKKGPAGPDWRFVRMLLRLVSGLRCSFDYPLAANPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MK1</accession>
    <name>Q63MK1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfoX_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531593.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110670.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0651"/>
    <dbReference type="EnsemblBacteria" id="CAH38108">
        <property type="protein sequence ID" value="CAH38108"/>
        <property type="gene ID" value="BPSS0651"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0651"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6849"/>
    <dbReference type="eggNOG" id="COG3070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLMAKWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="122" mass="13491" checksum="6F4DD77D8DBD6261" modified="2004-10-25" version="1">MNWKAEERRADELAEQLDALGPIGVARFFSGASLRLDGVLFGFVHAGSLFLRVDDDTRAAFERAGMRPFSYSGRTRTVVVGGYYETPADVLEDVGMLRDWCRDAHRAALRAGAGARRAKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR1</accession>
    <name>Q63MR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ATP-binding component of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pchH</name>
        <name evidence="13" type="ordered locus">BPSS0589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536514.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110610.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0589"/>
    <dbReference type="EnsemblBacteria" id="CAH38046">
        <property type="protein sequence ID" value="CAH38046"/>
        <property type="gene ID" value="BPSS0589"/>
    </dbReference>
    <dbReference type="GeneID" id="56530959"/>
    <dbReference type="KEGG" id="bps:BPSS0589"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6765"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ADPQTEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="335"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH38046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="575" mass="61057" checksum="5B27DB2CA1F8F5FF" modified="2004-10-25" version="1">MNAPLARMLRPFAAPLAAAVALQALAGVASLVPWLALGRIAEHWRAAADLDGAARAWLAAAVAAGACWLGGQTLALHLTHRVDADLCDRLRARLADHLQRLPLNWFARTGSDRIARYVDQDVRALHQLVAHAPADITQLIVVPGAALACLLYLNPALLAFALVPLVLAAALFRWMRSARFMPAFAERRAALEALMGDYAELARNPALVRQYPGAGIEAVALDSVAGFARAFSAWVGRIGGLGACTQVLLGTPLLLAWVVLGAMGLVLARAPVGELCVFALLIWAVAAPVRALGHGADALRDARAAAARLDALLALPGLPQPPDAGARPAPRDASIAIRGVCVEFDGVPVLHDIEATIEAGTTTAIVGPSGAGKSTLLTLLARFMDPARGEVRLGGVDLRMLPPRVLRERIAVVFQHAAALDVSIAENIALYRPDASRDDIRAAARAACLADRIDALPGGYDCRYGRDVRFSGGELQRLAIARALLSHAPLLLLDEPASALDPQTGRALRNALHGGARTRVIVSHDLAAVRQADQILVMDRGRIVERGTHRALLDARGLYARLWAERDRPAEEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MU7</accession>
    <name>Q63MU7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186901.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110572.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0551"/>
    <dbReference type="EnsemblBacteria" id="CAH38008">
        <property type="protein sequence ID" value="CAH38008"/>
        <property type="gene ID" value="BPSS0551"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0551"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6719"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CPMMIEH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021872">
        <property type="entry name" value="DUF3483"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11982">
        <property type="entry name" value="DUF3483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="641" mass="68112" checksum="668C49E25D3DD36A" modified="2004-10-25" version="1">MNPAILITALLWLSVAGLAFAVAKRSAYWRLGRATTPGAFGLANLLAIPKRYFVDLHHVVARDPYIAKTHVATAGGALAALALVFVNYGLAIYSPWLDRLILLAALAMLVGVVFVWRRRHAKAVPARLSRGPWNTLPWLLGAFALGLVLFMLVPAAAMSGAFALLCAALIGAGAFAMTVGAAKGGPMKHAIAGLLHLAFHPRQERFAATRDAYTGDGGATPPTALKPSDVERDEYGVAKPAEFRWNQLLSFDACVQCGKCEAACPAFASGQPLNPKKLIQDLVVGMAGGTDAAYAGSPTPGIPVGAHGGDPQRPIVSSLIEADTLWSCTTCRACVQECPMLIEHVDAIVDMRRNQALVHGAVPGKGAQVLANLRETGTMGGYDTAARYDWSVDLGAPVAQPGRPVDVLIVAGEGAFDMRYQRTLRALVKVLNHAGVDYAVLGRAETDTGDVARRLGDEATFQQMARRLIDTLGALSFKQIVTADPHVMHSLRNEYRALGGRYAVKHHTTFVAELAAAGKIKPQAADALREKRMTYHDPCYLGRYNGETEAPRKLLKTIGIQIVEMERHGMRGRCCGGGGGAPLTDIPGRQRIPDIRIADARAVGADVVAVGCPNCTAMLEGVVGPRPDVLDVAELVAASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MX3</accession>
    <name>Q63MX3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2169 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530041.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110546.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0525"/>
    <dbReference type="EnsemblBacteria" id="CAH37982">
        <property type="protein sequence ID" value="CAH37982"/>
        <property type="gene ID" value="BPSS0525"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0525"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6686"/>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAMAGLT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="1">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="738" mass="81816" checksum="C06ED14A2110DE83" modified="2004-10-25" version="1">MRHIKPQAALVATTNTQIGAQPMLGISVGIGFRLDQPSILVHEAAVWEALKAAAPSLPLYEAALPKQRAEWLLAGHSVHAVGAGARARDVDWTAWVELDGVRKIVSCATSLGDEQAQSGYARIAVDHRHAAAGGARENPFGVASGTPPLQQLRTFGVGPAPLAAMGAINPDWPERAQWMPTRPGTLDAMAQDGTHMGWPADVDLRFFQQAAPDQWARGECWTPGARFELSGFGPRGEGFAGELPRLAPVALVTRNGRPGIERLSFKQQTAWFLPDRGIGVLWWNGAVALDFLLDDSPTMLVTAFKDEAERIDIDALMKFADQRADLNCTDPLQQADHELMPAITRGWTWEMILDTEDHPRFAPAPRGYEEVRARVEQNRRELVEARDASERLSAFEEANRNAKLPGAPRGGENWRTRLRQAKTPELANVTIRDADLSSLRFDGWKFDDVRFERCTLDRSEWTNCRLNQVHAVDCSFADVKMSDGWWKGGKIQRCNLERSAWLNVEIERISLDECRLDDLKVAGGSWSMLSVQGRGGVRGDVQDVQWNSVSWSEVSAPGWTWTRVRADDLAIVECAMAGLAVSQCTLAKPSILLTDLSASVWQRSMLTFAVLSHGTSINGARLTDCVFKSSSLQELRADRVQVDHCSFMQLNAQHLHAQQSHWSRTVLDGANVMHAQLTGTSFDRCSLKEAMFYGADMRQTRMRDCNLVRVRTSWIHPPEAGAWRGNLSAGQLDVPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N01</accession>
    <name>Q63N01_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525527.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110518.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0497"/>
    <dbReference type="EnsemblBacteria" id="CAH37954">
        <property type="protein sequence ID" value="CAH37954"/>
        <property type="gene ID" value="BPSS0497"/>
    </dbReference>
    <dbReference type="GeneID" id="56531054"/>
    <dbReference type="KEGG" id="bps:BPSS0497"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6653"/>
    <dbReference type="eggNOG" id="COG2307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWIGRYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="1">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="35518" checksum="DF5AB817D96D9994" modified="2004-10-25" version="1">MLLGRTASGLYWMYRYIERAENTARIVDAGLRMALTRTSDAPAEWSSVLVSSGADDGYRQKYETYAADTVADYLLRDRDNPSSVLSCIECARSNARMVRTALTREAWESVNGAWLAIRRALAQPIRASALPAILDEIKRETALILGSFYSTMLRNEIFDFAQIGAFVERADNTARILDVKYHLLLPSVSHVGTILDNYQWESILRCVAAHRSYRWVYDVQYKPMNIADYLILNGRMPRSLRYCYGRVVSSLEHLAKDYGVTHGCHETAAKIKQSLEDNTVERVFKSGLHEFLTDFIAKNNSLGLEIAQAYNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N10</accession>
    <name>Q63N10_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537094.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110509.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0487"/>
    <dbReference type="EnsemblBacteria" id="CAH37943">
        <property type="protein sequence ID" value="CAH37943"/>
        <property type="gene ID" value="BPSS0487"/>
    </dbReference>
    <dbReference type="GeneID" id="56531063"/>
    <dbReference type="KEGG" id="bps:BPSS0487"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6639"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QPDRYDE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="711" mass="77107" checksum="16EC1A42223506F1" modified="2004-10-25" version="1">MQSLCELATSAGALGAQLENYLRSHADDSCKLLGVPLGMPLRVEIVDAGAPIETRRDERGATLRIGADDAQRVMAYTRSCNWANGIVLVPTLTRLVLAGAFDGLKAGEPRAMRAFAATRKADPTRNLGLLWGALNLLGLAGWVTLGSGDEHADYALTPAGARVVECVNAQRPLFTRLADATAMLQHLHALCHRRRENADESARYAALVRICIDGWPLPAARDDLERHADAQLRTAMDGLLLGPTWVALDMPVFEKHGAQQGKVAASFFEVFDAHREGVAIGDAWPHADRVALDAAWALLRHAGVADSEAGGARVRLNETGRIHRPIAAPYAGLAASYLRSYALLDELLFGNPDPLDVDRDGHIDRVMNVYASSGAGSGPASKEITTKIIRRLFDETPLDQQPAGISDMGCGDGSALRRLAQYVIESTRRGRHLADHPLIVIGADYNESARSRAADTLAALSDVPGVHVRVIDADISRPDRYDEAVAASGLTVKGPDGGPRAARLSDLLHTFMFLVHNRRLGVRSGEAADAILERHLRQVDRAHLRGVVERYYPGQLTVSDDAALPVALDTIKRAFRVAYSDAEGLVPGYVAAADLIDFVARWKPHAKHGFLVVEGHSPWAASLLDDAVAEPGRWTRTEQLPSVFNWGMHFLSRQFMAPFDEFMLAMCIAGLSPRDAIHGRIHPEGFPGPDLLDAYRFFSIADYVAYDAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N16</accession>
    <name>Q63N16_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939479.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110503.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0481"/>
    <dbReference type="EnsemblBacteria" id="CAH37937">
        <property type="protein sequence ID" value="CAH37937"/>
        <property type="gene ID" value="BPSS0481"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0481"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6633"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPVGCRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="445"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="541" mass="58331" checksum="6F8D97A51D3FAB9A" modified="2004-10-25" version="1">MDNFCRTNLPAPTDLPEFVFELPGLQYPARINCAAALLDDAVTRRGWGERVAIRTESGAAWSYRALFELSNRIANLLVCDGGLVPGNRVLLHGTNHPFLAAAWFAIVKAGGVVVTTMPLLRAGELSKVIAQAQVTHALCEAAVSAELRAAMAAAPGVAFARYYETDDAAAFEPLLHACPRTFEPVDTRADEPCIVAFTSGTTGRPKATVHFHRDVMAICHCFPQHVLKPNADDVFCGSPPLAFTFGLGALLLFPLSVGASVVLLQRAKPQRLLAAIGAHRVSILFTAPAAYRAMLDELGEHDIASLRKCVCAGEALPVPTRNAWLARTGIRIIDGIGATEMLHIFASADETQAKEGAIGKAVPGYRLAILDERGERLPPYHVGRLAVQGPTGCRYLNDARQRDYVRHGWNLTGDAAYLDEDGYLFYQSRADDLIISLGYTISPAEVEEALLSHADVLECGVVGAPDGRGGTLVCAHVVPRPGVHGCDALTAALQQHVKARIAPYKYPRRIEYHAAGLPRNDSGKLQRFKLRQAAEEDVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N59</accession>
    <name>Q63N59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551351.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110460.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0437"/>
    <dbReference type="EnsemblBacteria" id="CAH37893">
        <property type="protein sequence ID" value="CAH37893"/>
        <property type="gene ID" value="BPSS0437"/>
    </dbReference>
    <dbReference type="GeneID" id="56531114"/>
    <dbReference type="KEGG" id="bps:BPSS0437"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4432"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ANIYFAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="41550" checksum="26B0D5F3BC9C7CB9" modified="2004-10-25" version="1">MNANLASSATAGPVPQMARGLILLFAFSCGAIVANLYYAQPIIALIAPDLHMSGGMASLIVSLTQIGYAAGLFFLVPLGDLVENKKLMVVTALTSIASLALAATVRAPGLFLAVSLIVGFSSVAVQLLIPLAAHLAPSESRGRVVGTIMSGLLLGILLSRPVASFIADHFGWRAVFAFGAATMAVVTVLLMLTVPSRRPAHQATYMQLIRSLGRLVATQPALRERSLYQGLMFGSFSLFWSAAPVELMHRHHLSQSAIALFSLVGAMGASSAPIAGRLADAGHTGRATVVALGLAAASFAPALFVPGAGVAGLVATGILLDFAVQMNMVLGQREIYALDAHSRNRLNSIYMTSIFVGGAIGSALASALYEHGGWTWIAIVGALFPLAALARFAFASRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NJ2</accession>
    <name>Q63NJ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205384.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110327.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0307"/>
    <dbReference type="EnsemblBacteria" id="CAH37755">
        <property type="protein sequence ID" value="CAH37755"/>
        <property type="gene ID" value="BPSS0307"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0307"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6413"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDDLGEV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="13"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="470" mass="49429" checksum="4488BFD99653902C" modified="2004-10-25" version="1">MLINGLCIEGGGEPLPIVDPATGEPLAAPAAASAADLERAVAAAEAAFPAWRATTPATRASLLLALADEIDRQAGALARIESRNTGKPLHLVVQDELPAVADCFRFYAGAARTASGPSAGEYVEGHTSMVRRDPVGVVAQIAPWNYPLMMAAWKLAPALAAGNTIVFKPSEWTPLSIVALEAALARIFPAGVVNIVLGDGASVGRALATHPRVRMISLTGSVEAGKSVLAAAACNLKRTHLELGGKAPVLVFDDADLDAAVAGIRYAGFYNAGQDCTAATRIYVQRGIYDTLAQRLADAASTLRVGPPDRADAEMGPLVSAAHRARVERFVREAAALRHARVLTGGAPLPGPGCYYAPTVIAGVRHDDAPMRREAFGPVVTLTPFDTESQALRWANDSEYGLASSVWTRDAARGMRLAACIDAGVTWVNAHFTYTADMPHGGTKQSGYGSDLSTLGLADYTQPRHVMWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU4</accession>
    <name>Q63NU4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sigma interaction-related Fis-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prpR</name>
        <name evidence="8" type="ordered locus">BPSS0205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAH37650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0205"/>
    <dbReference type="EnsemblBacteria" id="CAH37650">
        <property type="protein sequence ID" value="CAH37650"/>
        <property type="gene ID" value="BPSS0205"/>
    </dbReference>
    <dbReference type="GeneID" id="56531340"/>
    <dbReference type="KEGG" id="bps:BPSS0205"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6275"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012704">
        <property type="entry name" value="Sig_transdc_resp-reg_PrpR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010524">
        <property type="entry name" value="Sig_transdc_resp-reg_PrpR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
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        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06506">
        <property type="entry name" value="PrpR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="324"/>
            <end position="563"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="634"/>
        </location>
    </feature>
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        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAH37650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="694" mass="74188" checksum="88FB43AAABB61E04" modified="2004-10-25" version="1">MSTLPETGVRPRVWAVGISRLRALFRDIADEYEERADLRIVARGYEEAITALATAGAERPDAIVAAGSNGTYLKARVRVPVVLVNPTGFDVMHALARARRDAGRIALVSYGETPPEVRSFAAAYGLDVVFASYQSAQEADTRVLEMRERGIETVVGPGLVTDLAANAGMGAVFVYSHASVRAAVNTALEVAHATHAEALRRERLDNLLQHLRDGVVALDREGRIEAINERLALALGVSPSAAVGRALDDLTPELRTLRAADGDTLATVRGVRYVVHRGPLASSGGAPGSVLTFQESRAVERLDRTLRSHQHAQQFTARYRLDDIVGTTPAIAYARDLARRYAKSDATVLILGESGTGKEMIAQSLHALSARRKYPFVAVNCGAFPESLLESELFGYEEGAFTGARRGGKAGLFEAAHRGTLFLDEIGEMPPSLQSRLLRVLQEREVVRVGSTEPVPVDIRVVAATHRPLFAAVEAGTFRADLYYRLNILNIGLPPLRERAADIPALAATLLAQAARREPRLAERLRDANDAARALDAANAALARYRWPGNVRELQNVIERIAVELADAGERGDAAVSADTLRAIAPEVFALDTLGGFGSFGSAAGGGHGDASGGDIDADADARRPTLVQRRRRAEADEIRAALDACGGDRDRACARLGISKTTLWRKLAASEGKARGNKRGGGHGGDNDEGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P83</accession>
    <name>Q63P83_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">kgtP</name>
        <name evidence="7" type="ordered locus">BPSS0061</name>
    </gene>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="36"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="450" mass="48750" checksum="B9EF774AFDD51AC0" modified="2004-10-25" version="1">MEPTFTETGARASEPHATTLAGRAASSGDKLQRLKSIFSASAGNLIEWYDWYVYSAFALYFAHSFFPAGNQTAQLLNTAAVFAVGFLARPVGGWLMGIYADRYGRRPALLVSVVLMCVGSLIIALCPGYDVIGTAAPVLLVVARLLQGLSVGGEYGTSATYLSEVATARDRGFYSSFQYVTLVAGQLVALALLIVLQQFVLTTQQLESWGWRIPFFIGAACALAAMRLRSSMEETGEFKRTLNARDKRGTLAELSKHPRAVLTVVGLTMGGTIAFYTYSIYMQKFLVNTVGMSKHDATLVSAASLALFAILQPVVGSISDRIGRRPVLIAFGVLGTLFTVPIMTAISRTHDVWTAFFLNMAALVIVSGYTSINAVVKAELFPAKIRALGVGFPYALTVSIFGGTAEYLALWLKQAGHESLFYWYVTAAIFCSLLVYVCMRDTGKHSLIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PB2</accession>
    <name>Q63PB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110057.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37476">
        <property type="protein sequence ID" value="CAH37476"/>
        <property type="gene ID" value="BPSS0033"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0033"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3942"/>
    <dbReference type="OMA" id="RRHMSYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="88" mass="10161" checksum="54B1FFCFD10DE817" modified="2004-10-25" version="1">MADSFNRRRRRHMSYVALEVLTEDANRYSLPELIGVGGVSPDVPHICEMLLADAQWPTIQAYLDRQELPYKFARPSTGRRVGRNNPCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PU6</accession>
    <name>Q63PU6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="6" type="ordered locus">BPSL3276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553005.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109872.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3276"/>
    <dbReference type="EnsemblBacteria" id="CAH37289">
        <property type="protein sequence ID" value="CAH37289"/>
        <property type="gene ID" value="BPSL3276"/>
    </dbReference>
    <dbReference type="GeneID" id="56593939"/>
    <dbReference type="KEGG" id="bps:BPSL3276"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1947"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KWVVVKV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009992592" description="Endolytic peptidoglycan transglycosylase RlpA" evidence="3">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="5">
        <location>
            <begin position="99"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="211" mass="22316" checksum="5BADA60DF548F85D" modified="2004-10-25" version="1" precursor="true">MKFRLPRHLGTLAVFFALTGCAVPPNAPTSEQAKSAASKDALRTAASGAASNNKESAGAPLNFDTALASMPAAGSQDVSRQSLADAKPIDAADISDFRQTGRASWYGKGFHGRRTANGERFNMNEFTAAHRTLPLASYVRVTNQANGKSVVVKINDRGPFSRGRILDLSYAAAKVIGLVHAGTARVKIQGLSPEEARVARDEMLASNSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q31</accession>
    <name>Q63Q31_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ordered locus">BPSL3193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3193"/>
    <dbReference type="EnsemblBacteria" id="CAH37204">
        <property type="protein sequence ID" value="CAH37204"/>
        <property type="gene ID" value="BPSL3193"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3193"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH37204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="454" mass="49857" checksum="DED9769142FF3F7B" modified="2004-10-25" version="1">MHRRRYLANSPSLAKPGRSTAKFGDLRRRAMFLLLALIVYRIGAHIPVPGIDPDQLAKLFQSQAGGILGMFNMFSGGALSRFTIFALGIMPYISASIIMQLMAIVSPQLEALKKEGQAGQRKITQYTRYFTVVLATFQAFGIAAALENQPGLVTDPGAVFRLTTVVTLVTGTMFLMWLGEQITERGLGNGISIIIFGGIAAGFPNAVGGLFELVRTGSMSIISAIIIVVLIAAVTYLVVFIERGQRKILVNYAKRQVGNKIYGGQSSHLPLKLNMSGVIPPIFASSIILFPATILSWFSSGERKGWMSDTLHNVAEALKPGQPVYVLLYTLAIVFFCFFYTALVFNSRETADNLKKSGAFVPGIRPGDQTARYIDRILTRLTLAGAIYIVFVCLLPEFLVLRWNVPFYFGGTSLLIIVVVTMDFMAQVQSYVMSQQYESLLKKANFKGGNIPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q47</accession>
    <name>Q63Q47_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Flavocytochrome MsrQ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">msrQ</name>
        <name evidence="10" type="ordered locus">BPSL3177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="7">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MsrQ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109771.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3177"/>
    <dbReference type="EnsemblBacteria" id="CAH37188">
        <property type="protein sequence ID" value="CAH37188"/>
        <property type="gene ID" value="BPSL3177"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3177"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2061"/>
    <dbReference type="eggNOG" id="COG2717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LHFFWMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01207">
        <property type="entry name" value="MsrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022837">
        <property type="entry name" value="MsrQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36964">
        <property type="entry name" value="PTHR36964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="9">
        <location>
            <begin position="77"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="26112" checksum="5684E77BE2B805F0" modified="2004-10-25" version="1">MQSSTFAGSASPGAGAHGRAPRRDAGRAGGAPGWLAPVKIAAFVAALYPLARIVFFGVTERLGANPIEFVTRSTGLWTLVFLCITLAVTPLRRLTGINALLRLRRMLGLYAFFYAVLHFTTYIWFDKWFDVVEIAKDVVKRPFITVGFAAFVLLIPLAATSPRAIARRLGRHWQTLHKAIYAIAAFGILHFWWMRAGKHDLALPKLYGAIVLVLLGWRVLVWARQRWGAAAAGGRAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q85</accession>
    <name>HIS1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="1">ATP-PRT</shortName>
            <shortName evidence="1">ATP-PRTase</shortName>
            <ecNumber evidence="1">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisG</name>
        <name type="ordered locus">BPSL3140</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199915.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109733.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q85"/>
    <dbReference type="SMR" id="Q63Q85"/>
    <dbReference type="STRING" id="272560.BPSL3140"/>
    <dbReference type="EnsemblBacteria" id="CAH37150">
        <property type="protein sequence ID" value="CAH37150"/>
        <property type="gene ID" value="BPSL3140"/>
    </dbReference>
    <dbReference type="GeneID" id="56594088"/>
    <dbReference type="KEGG" id="bps:BPSL3140"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2103"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229310" description="ATP phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <sequence length="218" mass="23067" checksum="5C6C63B4477451DD" modified="2004-10-25" version="1">MSAPLTLALSKGRIFEETVPLLAAAGVTVAEDPETSRKLILPTTDPNLRVIVVRATDVPTYVEYGAADFGVAGKDVLLEHGGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEEIMPISSRLVVNQAALKLKRAALKPFLDAFERASLGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QG4</accession>
    <name>Q63QG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL3059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527797.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109654.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3059"/>
    <dbReference type="EnsemblBacteria" id="CAH37070">
        <property type="protein sequence ID" value="CAH37070"/>
        <property type="gene ID" value="BPSL3059"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3059"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3491"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SDVACII"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="8">
        <location>
            <begin position="11"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="393" mass="42216" checksum="4A4BD419E3C33A6C" modified="2004-10-25" version="1">MPAMTAYHQTFDVAVVGGGLVGKTAALALTQAGHKTALLAQPAVPRPADLAFDSRIYALSASSQALLERLRVWQALDHGRLAPVYDMRVYGDAHAELHFSAFQSAVSQLAWIGESSLIECALDAALRFQPNLTWFDARAQGLDVTPGAATLALANGDVIECDLVVGADGAHSWVRSQIGSKVERRDYRQTGVVANFKAAQPHRETAYQWFRDGEIVALLPLPDGHVSLVWSAHTAHADELLALDPARLAAEVERVTLNRLGALECVTPAQGFPLALQTVDRLVAPRVALVGDAAHLIHPLAGQGMNLGLRDVAALADVLANREAFRDLGDTVLLRRYERARREDIRALMVATDGLQRLFSLPGALARIARNAGMALVGAQPLVKRWLVASALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM2</accession>
    <name>Q63QM2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL3001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205251.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109596.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3001"/>
    <dbReference type="EnsemblBacteria" id="CAH37012">
        <property type="protein sequence ID" value="CAH37012"/>
        <property type="gene ID" value="BPSL3001"/>
    </dbReference>
    <dbReference type="GeneID" id="56528703"/>
    <dbReference type="KEGG" id="bps:BPSL3001"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2269"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YNIQIAT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="2">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="3">
        <location>
            <begin position="325"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="487" mass="56014" checksum="5F846AFC45FD78D4" modified="2004-10-25" version="1">MLKTPMPTQHELEMVTLEELVPKDHLLRQIDAAVDFEFIRAKVAHLYCADNGRPALDPVVMFKLLFIGYLFGVRSERQLMREVQVNVAYRWFARFRLTDKVPDASTFSQNRRRRFTDTTVYQEIFDEIVRQAIKRGLVDGRVLYTDSTHLKANANKGKFDVVKLEQTPAAYTEALNAAVDADRAAHGKKPLDRDDDEPPSSKDTKLSRTDPDSGYMVRDDKPKGFFYLDHRTVDAKHAIITDTHVTPASVHDSQPYLDRLDRQRERFEFKVEAVGLDAGYFTPAVCQGLEERGIAGVMGYRTPNHKPGMFYKRQFKYDAYRNEYVCPQGQALPYSTTNRLGYREYKSNAQICGRCPVRSQCTNSAIAVKVVTRHVWERAKERVDARRLTEWGQRIYARRKQTVERSFADAKQLHGHRYARMRGLRKVAEQCLLAAAAQNIKKIAMLLARKRKKGPAGPDWRFVRMLLRLVSGLRCSFDYPLAANPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QT7</accession>
    <name>Q63QT7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LPS-assembly lipoprotein LptE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lptE</name>
        <name evidence="3" type="ordered locus">BPSL2937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LptE lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194132.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109531.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2937"/>
    <dbReference type="EnsemblBacteria" id="CAH36947">
        <property type="protein sequence ID" value="CAH36947"/>
        <property type="gene ID" value="BPSL2937"/>
    </dbReference>
    <dbReference type="GeneID" id="56593775"/>
    <dbReference type="KEGG" id="bps:BPSL2937"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2343"/>
    <dbReference type="eggNOG" id="COG2980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YADMQND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01186">
        <property type="entry name" value="LPS_assembly_LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38098">
        <property type="entry name" value="PTHR38098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="19946" checksum="599F0192CB208037" modified="2004-10-25" version="1">MIRRSFLMLVGSAVLLSACGFKLRGQQDYAFKRLYIAGAPPAAAARLTRLVEAGSDTKIVKTPDEADVVLNLAESRGQGTLTLDRFGTVQEYQLNYSLNYTLFGKDGTLLIPPSLIALNRAMTYSAKYTNAKAQESEILFADMQNDAIDQLMRRLAIVRTLHPEPGEGVPAVAPRAPLPPPPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QX6</accession>
    <name>RUVA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">BPSL2898</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194029.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109492.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QX6"/>
    <dbReference type="SMR" id="Q63QX6"/>
    <dbReference type="STRING" id="272560.BPSL2898"/>
    <dbReference type="EnsemblBacteria" id="CAH36908">
        <property type="protein sequence ID" value="CAH36908"/>
        <property type="gene ID" value="BPSL2898"/>
    </dbReference>
    <dbReference type="GeneID" id="56593684"/>
    <dbReference type="KEGG" id="bps:BPSL2898"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2391"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000224850" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="193" mass="20261" checksum="BFF323EB0FAA8AD3" modified="2004-10-25" version="1">MIGRIAGTLLEKNPPHILVDCNGVGYEVDVPMSTFYNLPHTGEKVVLLTQLIVREDAHLLYGFLTPPERSTFRELLKITGVGARMALAVLSGMSVAELSQAVTLQDAARLTRVPGIGKKTAERLLLELKGKLGADLGPLAGAASPSDHATDILNALVALGYSEKEALAAIKNVPAGTGVSEGIKLSLKALSKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R06</accession>
    <name>QUEA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="1">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queA</name>
        <name type="ordered locus">BPSL2868</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538740.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109462.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63R06"/>
    <dbReference type="SMR" id="Q63R06"/>
    <dbReference type="STRING" id="272560.BPSL2868"/>
    <dbReference type="EnsemblBacteria" id="CAH36878">
        <property type="protein sequence ID" value="CAH36878"/>
        <property type="gene ID" value="BPSL2868"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2868"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2429"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231324" description="S-adenosylmethionine:tRNA ribosyltransferase-isomerase">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <sequence length="360" mass="39153" checksum="2D1FA70C8777C1D8" modified="2004-10-25" version="1">MLTLSDFDFDLPPELIAQTALPERSASRLLEVDNTNPSAPPRLVDRRFAELPACVAPGDLLVFNDTKVLKARFFGRKASGGKIEVLIERVTGERTALAQIRASKSPPPGTTLTLADAFDVTVGERVEPFFTLHFPDDCLVLIERHGRLPLPPYIEHAPDAADETRYQTVFAANPGAVAAPTAGLHFDDAVLTALEARGVERATLTLHVGAGTFQPVRVENLAEHRMHSESYELTDALVEKIAATRARGGRVIAVGTTSMRALEAAARDAQAAGRPLAATRAETDIFITPGYRFRVVDRLVTNFHLPKSTLLMLVSAFAGIETIRAAYRHAIDARYRFFSYGDAMLLTRRDDAAEATHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR1</accession>
    <name>Q63RR1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, membrane permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL2610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185998.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109206.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2610"/>
    <dbReference type="EnsemblBacteria" id="CAH36618">
        <property type="protein sequence ID" value="CAH36618"/>
        <property type="gene ID" value="BPSL2610"/>
    </dbReference>
    <dbReference type="GeneID" id="56594866"/>
    <dbReference type="KEGG" id="bps:BPSL2610"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2745"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WLAYPFM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="312" mass="33735" checksum="80ABBBACE8AFDF31" modified="2004-10-25" version="1">MAAPLSGNGTSAAAAHRTSPLSAFADRWIPKLVLAPSVAIALIFIYGFIAVTGYLSLTNSRLLPNYDFDGFGRYSDLFGNDVWWTSAANLGWFGVPFIGICVVLGLFLAILLDQKIRNEGALRAVFLYPMALSFIVTGTAWQWILNPGLGLEKVMHDWGFTNFSFGWLDDPDKAIFCVVIAAVWQSTGFVMALFLAGLRGVDGEIFKAAQVDGATLPTIYRKIVIPSMRPVFFSVLLILCHITIKTFDLVVALTAGGPGTSSSLPAMFMYTYSFNRGQLGVGAASSVMMLATVVAVLVPLMYLESRSTRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR3</accession>
    <name>Q63RR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL2608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527557.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109204.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2608"/>
    <dbReference type="EnsemblBacteria" id="CAH36616">
        <property type="protein sequence ID" value="CAH36616"/>
        <property type="gene ID" value="BPSL2608"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2608"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2747"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQARCEL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="372" mass="40619" checksum="ED07442E3B4D1182" modified="2004-10-25" version="1">MASLSIRDVYKTYPNGVPVLKGVDIDIEDGQFLILVGGSGCGKSTLLNMIAGLETVTKGEIRIGDKVVNDLSPKDRDIAMVFQSYALYPSMTVRENISFGLNIRKVPKNQQKQIVDRVAAMLQIEHLLERKPGQLSGGQRQRVAMGRALARDPALFLFDEPLSNLDAKLRIEMRAEIKLLHQRLGTTIVYVTHDQIEAMTLGDRIAVMKDGVVQQFGAPQDIYDSPSNLFVAGFIGAPPMNFINGKLVEQGSGVGIELDTGAMRGVLNLPFDAKRMNGHVGRDVILGLRPERITDARSAHNGEGARLQPVDVTVDVTEPTGPDTHVFAQVNGKRIVSRVHPAANPQPQQKLSLLFDVSKAVLFDPSTEARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RS9</accession>
    <name>Q63RS9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide heptosyltransferase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">waaC2</name>
        <name evidence="2" type="ordered locus">BPSL2592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552532.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109188.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2592"/>
    <dbReference type="EnsemblBacteria" id="CAH36600">
        <property type="protein sequence ID" value="CAH36600"/>
        <property type="gene ID" value="BPSL2592"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2592"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2766"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DKKWPAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008920">
        <property type="term" value="F:lipopolysaccharide heptosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011908">
        <property type="entry name" value="LipoPS_heptosylTferase-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02193">
        <property type="entry name" value="heptsyl_trn_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="37129" checksum="271EA2BAEE7447D2" modified="2004-10-25" version="1">MKRILIVKVTSLGDVVQTLPVVADLHRAFPGVQVDWAVDESCADVVRWNTGVSRVLCAPLRRFKKARSPADLKAIAASISELRAHRYDAVIDLHGVYKSAIISFLARARRRYGYRNQDLGELGAMFAYNGRFGPRPACDAWHGMRVSAGQALGYEPQGRADYLLDVPPESREPHTAPLVALAEPGGPYALFFHATSNDDKRWPTDRWSAVAREMRARGLRVLLPWGSEREREEAQRIAARAPGAVVLPRLALADVARKIDRAALVIGVDTGFVHMAHALEKPTVMIFCATSRQHLGVSGAPHSLSIGDEGATPGVDDVLGAIEHVYPTGAVEQPRRVAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RV9</accession>
    <name>Q63RV9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase</fullName>
            <ecNumber evidence="8">3.1.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoT</name>
        <name evidence="8" type="ordered locus">BPSL2561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="3.1.7.2" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194871.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109158.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2561"/>
    <dbReference type="EnsemblBacteria" id="CAH36569">
        <property type="protein sequence ID" value="CAH36569"/>
        <property type="gene ID" value="BPSL2561"/>
    </dbReference>
    <dbReference type="GeneID" id="56594898"/>
    <dbReference type="KEGG" id="bps:BPSL2561"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2803"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="97"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="438"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="692"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="789" mass="88041" checksum="41E15105739602AE" modified="2004-10-25" version="1">MSTTPSSASSEAGHAEATASSHARQYIDAVLEQSFRHLFGPTATPEQPRKHGVVSIAKLTAALADYLGAEEIKEVKAAFHFSDEAHLGQYRQSGEPYITHPVAVAEICAGWKLDAQAIMAALLHDVMEDQGVTKSELAERFGPKVAELVDGLSKLDKMEFRSREEAQAENFRKMLLAMARDVRVILVKLADRLHNMRTLGAVPMEKRRRVARETLDIYAPIAHRLGLNNTYRELQDMSFANFNPHRYATLEKAVKAARGNRREVIGKILESVQRAMADAKIDAEITGREKTIYSIYKKMRDKQLSFSQVLDVYGFRIVVEHPLDCYTCIGVLHALYKPVPGKFKDYIAIPKVNGYQSLHTTLVGPFGAPIEFQVRTRKMHEIAEAGVAAHWLYKNGGADLNDVQKRAHQWLKSLLDIQSEAGDSSEFLEHVKIDLFPDAVYVFTPKSKIMALPRGATALDFAYSIHSDLGNQCVAVKINNELLPLRTELKSGDIVEVITAPYSKPNPAWLGFVRTGKARSAIRHYLKTMRLNESVQLGERLVDQSLKGYGLALADVTPEVWEKLVQWTGNKSRQEIFADIGLGRRVAAVMAKRIEVLMSGRDADDDLPRAERHAANHAPPVVITGTEGMSVQLSACCRPIPGDDIMGYIGIGLGMAIHTTACRVAQRIHRRDPGRWIDVAWAPQPGRLFDVAVKALVKNTKGIFARVAADITSADANIVHIAMDEDLTHESTVLRFVIQVSDRVHLANVMRRVRTNPDVMRIMRERSNDDVVHARHDGGMRIDRERQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SA6</accession>
    <name>Q63SA6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193834.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109010.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2418"/>
    <dbReference type="EnsemblBacteria" id="CAH36421">
        <property type="protein sequence ID" value="CAH36421"/>
        <property type="gene ID" value="BPSL2418"/>
    </dbReference>
    <dbReference type="GeneID" id="56596330"/>
    <dbReference type="KEGG" id="bps:BPSL2418"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2975"/>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DNYIACS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="54"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="170" mass="18095" checksum="47307EB27A454D37" modified="2004-10-25" version="1">MFALSEALPSSKPALYETLAAQARALVETETDIVANAANFASLVYHSLDGLNWAGFYFFDGRELVVGPFQGKPACVRIPLGKGVCGTAAQTRGTQVVHDVHAFAGHIACDSASQSEIVVPLVARDGALIGVWDVDSPLVGRFDAEDAIGMEALCRVFVEVAWENATRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE6</accession>
    <name>Q63SE6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527428.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108970.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2377"/>
    <dbReference type="EnsemblBacteria" id="CAH36379">
        <property type="protein sequence ID" value="CAH36379"/>
        <property type="gene ID" value="BPSL2377"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2377"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3030"/>
    <dbReference type="eggNOG" id="COG2703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QEDRWMQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016131">
        <property type="entry name" value="Haemerythrin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00550">
        <property type="entry name" value="HEMERYTHRINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="141" mass="16390" checksum="F315133151FEF3FB" modified="2004-10-25" version="1">MQDLSTELAPELKLDDPFVDAVHTEFVQLLDAAARADDAHFLQAYDVWMDHCRQHFEREERWMASTKFGPQYCHAADHNEVLKVAADVREKLARDAQFELGRRLLVEVAEWFDQHVRTMDSMMVSHLKMLNFAMVDVPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SG4</accession>
    <name>Q63SG4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524671.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108952.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2359"/>
    <dbReference type="EnsemblBacteria" id="CAH36361">
        <property type="protein sequence ID" value="CAH36361"/>
        <property type="gene ID" value="BPSL2359"/>
    </dbReference>
    <dbReference type="GeneID" id="56528828"/>
    <dbReference type="KEGG" id="bps:BPSL2359"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3051"/>
    <dbReference type="eggNOG" id="COG4273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMCCLSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014958">
        <property type="entry name" value="DGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08859">
        <property type="entry name" value="DGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037181">
        <property type="entry name" value="DGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="148" mass="15472" checksum="66CE2B5B28653994" modified="2004-10-25" version="1">MNHETKTLPIVYSCSGCSNVAQLANHVAVRLDRGGDAEMSCIAGVGGDVPSLLKIAHSGRPILAIDGCPLVCAKKSLERHGIAPDAHLQLGEHGVRKRFHEDFAPGDASRILAIAKAEAARLAGSRPAPEPELAQAGEDAGAALERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SJ5</accession>
    <name>Q63SJ5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino-acid acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acetylglutamate synthase</fullName>
            <shortName evidence="8">AGS</shortName>
            <shortName evidence="8">NAGS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argA</name>
        <name evidence="11" type="ordered locus">BPSL2325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the acetyltransferase family. ArgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192168.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108921.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2325"/>
    <dbReference type="EnsemblBacteria" id="CAH36328">
        <property type="protein sequence ID" value="CAH36328"/>
        <property type="gene ID" value="BPSL2325"/>
    </dbReference>
    <dbReference type="GeneID" id="56596124"/>
    <dbReference type="KEGG" id="bps:BPSL2325"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3098"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRKYNWD"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04237">
        <property type="entry name" value="AAK_NAGS-ABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01105">
        <property type="entry name" value="N_acetyl_glu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033719">
        <property type="entry name" value="NAGS_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000423">
        <property type="entry name" value="ArgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01890">
        <property type="entry name" value="N-Ac-Glu-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="312"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="458" mass="49792" checksum="41BC05A2F0A2EC17" modified="2004-10-25" version="1">MNSQTDLPAAQSGAAPQPSVDEAVHHAQFVDWMRSVAPYIHKFRNSTFVVGFGGEVVQHGLLSALVSDIALLQAMGIQIVLVHGSRPQVEEQLHLHGVESAFSHGLRITDARALESAKEAAGEVRLDIEAAISQGLPNTPMAHAHISVVSGNFVTARPVGILDGVDFAHTGVVRKIDAESIRHSLASRKLVLLSPLGFSPTGEAFNLSMEDVASAAAIALRADKIIFLTESPGIVDEAGELVREMSLDAAAELLDSGDLQGDDGFFLKHAIRACRGGVARAHLIPQSLDGSVLLELFLHDGVGTMISYENLESLREATPDDVGGILTLIEPLETDGTLVRRGRHQIERDIDHFSVIEHDGVLFGCAALYPYPTEKIGEMACLTVAPEAQGSGDGERLLKRVEQRARARGLTRIFVLTTRTEHWFLKRGFVKATVDDLPEDRRKLYNWQRKSLVLMKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ST4</accession>
    <name>Q63ST4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550237.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108832.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2237"/>
    <dbReference type="EnsemblBacteria" id="CAH36239">
        <property type="protein sequence ID" value="CAH36239"/>
        <property type="gene ID" value="BPSL2237"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2237"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3203"/>
    <dbReference type="eggNOG" id="COG3240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWIGGND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00869">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266757" evidence="1">
        <location>
            <begin position="24"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Autotransporter" evidence="2">
        <location>
            <begin position="333"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="610" mass="64290" checksum="961D6B676DB107E2" modified="2004-10-25" version="1">MTIGSKTKLALGIALAMPAAAWAYTFYALGDSLTDNGRVVRLTGILPNATSTIFRGGRSSNGPVWAEYLPGLIGARFAPDDDYAINGALSGHGGYLNIIPTRPTWRTLPGFADQVEQLIAAHPRLRRDDLVGVWIGTNDQDLTKASLNGIEPFLGVPRPANIAEMSAYTLTNLNAQLQRLIGAGARQFVILNLNDAGGTRPGYVDYNGKLPEDLARFSRQGVNVHLFDVSALLNQMRRNPSAYGLNDTPDVQCRYVPSCSGGSVELQNTYLTADGTHMMTSVHEYIARYLANQLNAPAAISTAPVLGLDVARAGALSALNAADGGPLGPARVAWSDRLSLFADVGYTRNFHGAAGGMNAFDSDVEMFSIGADYKLSEASRAGALLSSGNANGSLAGGQGRIGLHAYRLGVYHAFERAGLFVRAYAGAGWSRYRLDRAAVLPGAVRASTSGFDFGALVKAGYLFALGGVRLGPVADVGYTQLVARGYTEDGDPILAQNVGVQRLKGVSAGAGVRFAAPLAAIGLRAGELSAEAQLRHDAFGDRTLVTAQRYAPGLPIGTAVDGASATYERLSVALTVNPAKRWRGKLVVQTDLGTAPRRSYTLLALLGGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV2</accession>
    <name>Q63SV2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="8">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">serC</name>
        <name evidence="10" type="ordered locus">BPSL2219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="8">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524767.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108814.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2219"/>
    <dbReference type="EnsemblBacteria" id="CAH36221">
        <property type="protein sequence ID" value="CAH36221"/>
        <property type="gene ID" value="BPSL2219"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2219"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3226"/>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHRSDWF"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6 8" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="7"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="8">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="364" mass="40054" checksum="2D0D56E449025459" modified="2004-10-25" version="1">MHRNQLNFSGGPGALPDTVLEQVRQAVVELPETGLSVLGMSHRSSWFSSLLAQAQADLRDLLGIPDEYGVVFLQGGSSLQFSMIPMNFSRPGAAAPEYVTTGYWSRKAIGEASRVAAMRVVWDGAASGYRTLPSLAALDWDARAPFRHYVSNETVEGLQFPDAADLPGSPLIADMSSDFMSRPFDVRAYGMVYAHAQKNLGPAGVTVAIIRRALLERVPDTLPPMLDFRTHVEHRSNYNTPPVFAIYVMALVLRWIRDEIGGVHAMRDINARKAAMLYATLDALNEVIDCHAHRAARSTMNVAFRFRQPRLDTLFKEQSTEAGFCGLSGHRSIGGIRASLYNAVSEQAVSRLCAFLKDFAIRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SZ1</accession>
    <name>Q63SZ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266648.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108775.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2180"/>
    <dbReference type="EnsemblBacteria" id="CAH36182">
        <property type="protein sequence ID" value="CAH36182"/>
        <property type="gene ID" value="BPSL2180"/>
    </dbReference>
    <dbReference type="GeneID" id="56595963"/>
    <dbReference type="KEGG" id="bps:BPSL2180"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2476"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ICFGFNP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="435" mass="46891" checksum="35AF8AF633E28746" modified="2004-10-25" version="1">MKKGFYSIMAAQFFSSLADSALLIAAIALLKDLHAPNWMIPLLKLFFVLSYVVLAAFVGAFADSRPKGHVMFITNSIKVVGCLIMLFGAHPLIAYGIVGFGAAAYSPAKYGILTELLPPERLVAANGWIEGTTVGSIILGTVLGGALISPKIASHVIAHTPPSINTPAEAAMLVIMTIYVTAALFNLRIPDTGARYPRQQHGPLKLVTDFADCFMALWRDKLGQISLAVTTLFWGAGATLQFIVLKWAEVSLGMSLSEGAILQAVVALGVAAGAMIAASRIPLRKSLTVLPVGIVMGIAVMLMAFYTRELFPAHWALHLGRLHLPVYLLVAYVFLMFVGALSGFFVVPMNALLQHRGHVLLSAGHSIAVQNFNENLSVLVMLCVYAALVWLDVPVGIVIVLFGTFVCLTMWLVMRLHVANQRRFDSVALIGESKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T99</accession>
    <name>Q63T99_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526732.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108667.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2068"/>
    <dbReference type="EnsemblBacteria" id="CAH36069">
        <property type="protein sequence ID" value="CAH36069"/>
        <property type="gene ID" value="BPSL2068"/>
    </dbReference>
    <dbReference type="GeneID" id="56595331"/>
    <dbReference type="KEGG" id="bps:BPSL2068"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.58"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DNVWGYQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="28947" checksum="CBFD37AF2DECA37E" modified="2004-10-25" version="1">MSAARKVLLVEDDEAQANWAKLVLTRGRFDVTHCQTGGQAIRAMTKEVPDAVVLDMRLPDVHGLEVLVWIRRNFFDVPVIVLSNAMQEMQIVEAFSAGADDYVLKPAREAEFLARIAAMMRRKGHAVSGTIEIGGIAIDLGWKAVRIDGEPVRMAPIEYEILEMMARHLGSVVQREVLVNRIWGRSIDEAVSRSLDTHVYRIRHKLKVHGVSNVSLRSVYNLGYRLEWCRGRALAGAAPERDDALRLAEGGGEAMLPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TS4</accession>
    <name>Q63TS4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative fimbriae-related outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL1892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526866.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108492.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1892"/>
    <dbReference type="EnsemblBacteria" id="CAH35892">
        <property type="protein sequence ID" value="CAH35892"/>
        <property type="gene ID" value="BPSL1892"/>
    </dbReference>
    <dbReference type="GeneID" id="56529590"/>
    <dbReference type="KEGG" id="bps:BPSL1892"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4035"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ETRMSAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="9">
        <location>
            <begin position="168"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="36164" checksum="55FB36FA3ADEB76C" modified="2004-10-25" version="1">MSSAALWALALALLCVAGAFALWRRGEANRERAHAARYIDSRLEPGARASAQPKMPAAAEPKRAAPMPAAGAAGGARAEKPAEGLARWRERAADAWLNVSNRAGVSEIRAPLAALAATTAVATLWAGLRGGLLAACAALVAGATLAVFWLVSRMQKRRLRIVRQLPSFLDGIVRLVTLGNSVPAAFQATLQTTEAPLRGCLDHVSRMLRSGVEIDRAMVSIAALYRIKEFELVGSVLRLSVKYGGRADVMLDRMAVFMRDLEQAERELVAMSAETRLSAWVLGALPVGIGSFVIATNPKYFSAMWLDPTGRQLVYLAFILQIAGGYWLYRLARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TZ9</accession>
    <name>Q63TZ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbriae assembly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108417.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1818"/>
    <dbReference type="EnsemblBacteria" id="CAH35817">
        <property type="protein sequence ID" value="CAH35817"/>
        <property type="gene ID" value="BPSL1818"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1818"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2046"/>
    <dbReference type="eggNOG" id="COG4964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWSTIGN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032789">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13629">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SS-T3SS_pil_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="439" mass="46222" checksum="3F14D41B39F6736A" modified="2004-10-25" version="1">MAVAPRFARAADLGPVLAVPAGGGEMVKLPAPAVAVFVADPDVADVHVPTPQAVFVLGKKAGTTTLFALGANNRTILRETVVVDVDTPSLQRILDARFPQLRLTLAGAPGSLMVSGRVPSAADADAVVQTLKPYLRQQEALVNRLTLARPIQVHLRVRITEVDRNITQQLGINWSALGASGNFVGGLFNGRTLFDTASKAFDLSPSGAFSVVGGFHTSRYSIDGVLDALDQEGLITMLAEPNLTAISGQTASFLAGGEFPIPVAQDTTGAITIQFKPYGVSLDFTPTVLADNRISLKVRPEVSEIDPTNSVTTGSIKVPALTVRRVDTTVELSSGQSFAIGGLLQSKSSDVLAELPGLARLPVLGKLFSSRNYLNDKTEVVVIVTPYIVQPANPGELRDALDDVTRPSSDIEFVLQRSLGIDPLGGDAPRLAGPAGFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U17</accession>
    <name>Q63U17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative outer membrane usher protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL1800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell outer membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the fimbrial export usher family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108399.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63U17"/>
    <dbReference type="STRING" id="272560.BPSL1800"/>
    <dbReference type="EnsemblBacteria" id="CAH35799">
        <property type="protein sequence ID" value="CAH35799"/>
        <property type="gene ID" value="BPSL1800"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1800"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2025"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GANWGAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018030">
        <property type="entry name" value="Fimbrial_membr_usher_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025949">
        <property type="entry name" value="PapC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043142">
        <property type="entry name" value="PapC-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025885">
        <property type="entry name" value="PapC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037224">
        <property type="entry name" value="PapC_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13953">
        <property type="entry name" value="PapC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13954">
        <property type="entry name" value="PapC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141729">
        <property type="entry name" value="SSF141729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01151">
        <property type="entry name" value="FIMBRIAL_USHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="10" id="KW-1029">Fimbrium biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267561" evidence="11">
        <location>
            <begin position="22"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="PapC_N" evidence="13">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PapC_C" evidence="12">
        <location>
            <begin position="738"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH35799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="822" mass="87683" checksum="3330C0F78CE20462" modified="2004-10-25" version="1">MRIRHSFLCVFMLAAGSHARATEFNASFLSIDGRNDVDLSQFAQADYTLPGTYLLDVQVNDVFFGLQPIEFVAHDDGQGARACVAPELVAQFGLKKSLVENLPRTMGGRCADLASLDGVTIRYQKGEGRLKITIAQAALEFADASYLPPERWSDGVDGAMLDYRVLANANHAFGRGAQQNNAVQAYGTIGANWGAWRFRGDYQAQTRAGGAVYAERAFRFNQLYAYRALPSIRSTLSFGEIYVDSDIFSTFSMSGVAMKSDDRMLPPSMRGYAPLVTGVARTNAIVKVMQDSRVLYMTKVSPGAFALSNLNTSVQGTLDVVVEEEDGTVQRFQVATAAVPFLAREGQLRYKTAIGQPRTFGGAGITPWFGFAEAAYGLPFDVTVYGGLIAASGYTSVAFGVGRDFGRFGALSADVTHARATLWWNGRTKRGNSYRINYSKHVDALDADVRFFGYRFSERDYTNFQQFSGDPTASGLANGKQRYSAMLSKRFGDTSTYFSYDQTTYWARPSDRRIGVTLTRAFSLGALKSVNLGFSAFRTQGAGGGGNQVSLTATLPLGERQTLTSSVSAGEGGTSVNAGYLYDGANGRTYQLYGGTTDGRASANASLRQRTPSYQLTAQASTVANAYASASLEVDGSFVATRYGVTAHANGNAGDTRLLVSTDGVPGVPLSGSYARTNARGYAVIDGVSPYNVYDATVSVEKLGLDTDVTNPIQRTVLTDGAIGYIRFNAARGRNVFVTLTGDGGAPVPFGASVQDAATGKELGIVGEAGAAYLTQVQPRAKLVVRAGAKTICTPAALPDTLQLDGTPAPVACEAAAQHASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U52</accession>
    <name>Q63U52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108364.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35763">
        <property type="protein sequence ID" value="CAH35763"/>
        <property type="gene ID" value="BPSL1764"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1764"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1981"/>
    <dbReference type="OMA" id="RAKTHRH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267565" evidence="2">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="12146" checksum="6B57FC222B8510CB" modified="2004-10-25" version="1">MTIGRWSDAARLQYPERVDLPGAAMKRFLSCVALVCFALPAAHAQTQTYHFEEGGTTPTGVTSQPASAAAQARTQRAKPHRHPVRRNKHHRTHRRARSAQNDRFYSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U75</accession>
    <name>Q63U75_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198172.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108341.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1741"/>
    <dbReference type="EnsemblBacteria" id="CAH35740">
        <property type="protein sequence ID" value="CAH35740"/>
        <property type="gene ID" value="BPSL1741"/>
    </dbReference>
    <dbReference type="GeneID" id="56595526"/>
    <dbReference type="KEGG" id="bps:BPSL1741"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3840"/>
    <dbReference type="eggNOG" id="ENOG50345YU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESTMRIC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="110" mass="12988" checksum="27D68492D42F9ECE" modified="2004-10-25" version="1">MRICIENIQPGVTREELQAFLFKYTGKTFTDIQFIGQSGPRPGALIDIDGANWSALAEIRRRLHGMYWKRRRIGVWLFSFWDRSDAAEARRQREARTRQTRSTPMTTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UD0</accession>
    <name>Q63UD0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531312.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108286.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1676"/>
    <dbReference type="EnsemblBacteria" id="CAH35675">
        <property type="protein sequence ID" value="CAH35675"/>
        <property type="gene ID" value="BPSL1676"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1676"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3756"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QDPYGFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266592" evidence="1">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="544" mass="57484" checksum="8C2234B96DF2B3D3" modified="2004-10-25" version="1">MQRFLTRSAIALALFAAVPAFADVTLDGRSVTPESIARIADGEAVSIAPAARQRVVAAHEVLLKAAAAGQQIYGLTVGVGLNKDREMVDAHGKLSQEVIDASTRFNIGLIHAHSGSVGPDMSVRVARAAMAARLNAMLDGGAGVQPAIVDAYAQFLNRGVTPAMPADGSIGEADITILSHVGLAMLGEGDVYYQGRKLAAADALKLAGIATIYPYGKDALAILSSNAYSAGMAALALTDMARLARVSKLVFALGLQGLNGNVSPFREDTLALRPFPAALRAGAALRTLLAGSSLWNKDPDRPLQDPLSFRSGVYLLGEEDRTYDEARALLQVQLNSSDDNPGVAVSVAPKSNRAQDAAGYVDGGGAVLPSANFEPLPWVLAFEQLGLALGHNALASAQRIVKLNDSHLSGLSRFLGTEETVHAFGAMEKPPTALAMTIKTLATPVSLDYLPVAGGIEDIATNAPEVVQRVQKQIDASYTLLGLELIEAAQAIDLRRRRQPSFTLAPATQPLYRALRAKVAFLERDRPLTPDFRAADTLLRAYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UF9</accession>
    <name>Q63UF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative betaine aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527057.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108257.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1647"/>
    <dbReference type="EnsemblBacteria" id="CAH35644">
        <property type="protein sequence ID" value="CAH35644"/>
        <property type="gene ID" value="BPSL1647"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1647"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1858"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WINLSQA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="17"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="490" mass="52676" checksum="14C0A818BF713EE4" modified="2004-10-25" version="1">MLQRFQQYIDGTFEHAASEFDSIDPAGGTVWARMPAASADDVDRAVRAAHRALNEAAWANLTASERGKLLYRLAELIERDALRLAELETRDTGKIIRETRSQIGYVAEYYRYYAGVADKIQGAWLPVDKPDMEVTLRREPVGVVAAIVPWNSQLFLSAVKVGPALAAGCTVVLKASEDGPAPLLEFARLVHEAGFPKGVVNIVTGFGNDCGRTLTSHPLVSHIAFTGGPETARHVVRNSADNLAAISLELGGKSPVLVFDDADLESTCNAVIAGIFAATGQSCVAGSRLIVQRGIHDALVERLTARARAIRIGDPQDMATEMGPLATRRQLEHIQRVLDASIEAGGRVVTGGSQPEGLAAGHYFLPTIVDCPNAKVPSVMEELFGPVLSVVMFDTEAEAIALANDTKYGLASGVFTGDLTRAHRLTRALRAGIVWVNTYRAVSPIVPFGGYGLSGLGREGGFEAVLEYTRTKSVWIRTSDEPIADPFVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UI6</accession>
    <name>Q63UI6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531357.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108230.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1614"/>
    <dbReference type="EnsemblBacteria" id="CAH35614">
        <property type="protein sequence ID" value="CAH35614"/>
        <property type="gene ID" value="BPSL1614"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1614"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3675"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HASRRHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="346" mass="39671" checksum="884CEB8BA3331E2A" modified="2004-10-25" version="1">MATVDEDDIGTASGRDEGDWVPNRFCLRNAWFPLAHTFEIGERASRWQIYSQPCYLWRARGRIHASRRHPDLPAAPAMPAAPDSPFEPPERYPVVERFGYAWIWYGDPEHASDALVPDVPFLPREGGLPERMQGNIRLDCCTPLLVENLLDLTHADYLHANLLGDEQSEEDRVDVRFTSETVTMIRQCTNKSIAPIMRWFGGVRAKYQDVHVVIHVHVRSSVAVAYGRYMPGIDLPIFHPCVPESRDRCRLSFALNMTRTPWLLRALMPLTPYIVLPQDNRMIGPQSTRYRDAGERRDLYSRFDRAGLRYRLLLQQLARRQRDGDFSYAPDALPGQDARGILGMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UL2</accession>
    <name>Q63UL2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550374.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108204.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1588"/>
    <dbReference type="EnsemblBacteria" id="CAH35587">
        <property type="protein sequence ID" value="CAH35587"/>
        <property type="gene ID" value="BPSL1588"/>
    </dbReference>
    <dbReference type="GeneID" id="56529309"/>
    <dbReference type="KEGG" id="bps:BPSL1588"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3640"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIFCKIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="153" mass="16931" checksum="DEDF71F6D4A3DBC1" modified="2004-10-25" version="1">MRPPRLDQLDDLDRNLVALLQANARASVADLARQLGVARTTVLARIARLERTQVIAGYSVRLGQDVLDASIYAYVGIILAPKYGKDVLKRLDRMPEVQLLCAVSGEYDYVAWLRADSPERLNDLLDQIGALEGVERTTTSIILARKIDRGTLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US9</accession>
    <name>DER_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">der</name>
        <name type="synonym">engA</name>
        <name type="ordered locus">BPSL1517</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192452.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108137.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63US9"/>
    <dbReference type="SMR" id="Q63US9"/>
    <dbReference type="STRING" id="272560.BPSL1517"/>
    <dbReference type="EnsemblBacteria" id="CAH35518">
        <property type="protein sequence ID" value="CAH35518"/>
        <property type="gene ID" value="BPSL1517"/>
    </dbReference>
    <dbReference type="GeneID" id="56595744"/>
    <dbReference type="KEGG" id="bps:BPSL1517"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3555"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_1000011585" description="GTPase Der">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 2">
        <location>
            <begin position="180"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="KH-like" evidence="1">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <sequence length="445" mass="49077" checksum="D0648A3F30D69612" modified="2004-10-25" version="1">MKPVIALVGRPNVGKSTLFNRLTRSRDALVADLPGLTRDRHYGEGRVGARPYLVVDTGGFEPVAKDGILHEMARQTRQAVEEADVVVFIVDGRNGLAPQDKSIADYLRKTGRPIFLVVNKAEGMKYTAVASDFYELGLGDPRAISAAHGDGVNDMINEALEVAYAGEPQESEEAAAARGIKIAIVGRPNVGKSTLVNTLIGEDRVIAFDMPGTTRDSIYVDFERNGKHYTLIDTAGLRRRGKVFEAIEKFSVVKTLQSISDANVVILLLDARQDISDQDAHIAGFVVEQGRALVVGVNKWDGLDPHVRERTKADLARKLKFLEFAKFHFISAAEKTGIGALMRSVDDAYAAAMKKLPTPKLTRALIEAVEFQQPRRRGPVRPKLRYAHQGGQNPPIIVIHGNALDAVTETYKRYLENRFRETFSLTGTPLRIEFRSSTNPYADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UY9</accession>
    <name>Q63UY9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192197.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108077.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1455"/>
    <dbReference type="EnsemblBacteria" id="CAH35457">
        <property type="protein sequence ID" value="CAH35457"/>
        <property type="gene ID" value="BPSL1455"/>
    </dbReference>
    <dbReference type="GeneID" id="56595810"/>
    <dbReference type="KEGG" id="bps:BPSL1455"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3482"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGHIHQV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266360" description="Metallophos domain-containing protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="44"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="306" mass="33537" checksum="BFAF92ACB0362D62" modified="2004-10-25" version="1">MPNPIQPLKRRDFLRLAACGGGVAFASALPGWSFAANAGADFFFVQLSDAHWGFTGPAINPDARGTLPKAIEAVNALPVAPDFVMFTGDLTHTTDDPAERRARMRQFQSIVAQLRAKPLHLMPGEHDASLDAGAAYREIFGDTHYAFDHKGVHFVVVDNVSDPAGRVGDAQIEWLARDLARQPKDARIVVFTHRPLFDLAPQWDWATRDGAKVVDVLMPYPNVTVFYGHIHQEHHAMTGHIAHHAARSLMFPLPAPGSQDKRLPVPWDAAAPYRGLGWREVRVGDAARAPALTEMPVAAPQPQPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V43</accession>
    <name>Q63V43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550291.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108023.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1401"/>
    <dbReference type="EnsemblBacteria" id="CAH35402">
        <property type="protein sequence ID" value="CAH35402"/>
        <property type="gene ID" value="BPSL1401"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1401"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3411"/>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATIRICA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="387" mass="39034" checksum="01B75AAD37350F7A" modified="2004-10-25" version="1">MPQPSPIVVIAPDSFKGSLSAEQVANAIAAGVARARPDALVRRCPMADGGEGTLDALLAHGGTRRTLRVPGASLAPRDAAVGLIDARTAVVETAEIVGITDPAGMSAPVAARSTRGLGSAIRALLDDGVRTFYVALGGSSTNDAGAGLLAGLGMRAFDAQGREIEPTPERLAHVARVDFAGLDARVAGASFVAMSDVDNPLTGAHGATAVFGPQKGVAPAQVAPLDAALDHFATLVEAALALRPTAAAHARARDLPGAGAAGGLGFALHVLGARFEPGAEVIARQIGLDAALAGANWLLTGEGRSDAQTLHGKAPFVACRHARAAGVPATLLSGAIDPAALPQLSEHFDGCFSPAPGPITLEAALRDAARLLENAAEQLARLRYGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VC2</accession>
    <name>Q63VC2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107944.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35317">
        <property type="protein sequence ID" value="CAH35317"/>
        <property type="gene ID" value="BPSL1320"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1320"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1477"/>
    <dbReference type="eggNOG" id="ENOG5031TNW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTRIVLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021344">
        <property type="entry name" value="DUF2970"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11174">
        <property type="entry name" value="DUF2970"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="64" mass="6902" checksum="26D07504F79CE98E" modified="2004-10-25" version="1">MAMSLARMMRMVLWSFFGVRKGAGHQADLASVKLPWVPVMAILLAACFGGLLFGLAKVAITVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF4</accession>
    <name>Q63VF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL1290a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107912.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1290a"/>
    <dbReference type="EnsemblBacteria" id="CAH35285">
        <property type="protein sequence ID" value="CAH35285"/>
        <property type="gene ID" value="BPSL1290a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1290a"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="119" mass="12766" checksum="ECAD5E5F5798FF95" modified="2004-10-25" version="1">MIEEPNSRDAKADMTPARKNFSGPALAPPDNDRASARARKQTRASKPRAHADARPAHDRRTIDASSAHGPATPMRGATVPARAARTRLRGANPVRAASRRRGAISATDRGRARNRSVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF9</accession>
    <name>Q63VF9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107907.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63VF9"/>
    <dbReference type="STRING" id="272560.BPSL1286"/>
    <dbReference type="EnsemblBacteria" id="CAH35280">
        <property type="protein sequence ID" value="CAH35280"/>
        <property type="gene ID" value="BPSL1286"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1286"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1428"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NWSRRAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="403" mass="44417" checksum="03B4376F604C129D" modified="2004-10-25" version="1">MRYHDVTLASAFQPVISITHKRVVGYEALARATDANGAPISPDTLFARAQARGETILLDRLTRCLHVANFAAQDTGACWLFLNVLPQMFDAGIAPGAFIEALCAHFALPPTRVVLEVIEQPSRNEVALARTIDMIQHGDFLIAVDDFGTGFSNFDRIWQIKPDIVKLDRSILERSLAASDAHRIIHHLVTMLHHAGTMVLAEGVENEDALQILMDADVDFVQGFCFGRPAPSLEHARRAAPARIEAAWRRFAERTKARCGDVVHPGFDTIERIMLTGAADYAQTRNLRDAAQRLLTSPIVRRVFVAEANGEQVEPSVTIETPEAPSATARRLAPLLPELHCNWSRRAYFQRAIAAPGRVALMGPHFSLTDGRDCYTAAVAIHLGTTLKVFCVDFDFSSYGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VG3</accession>
    <name>Q63VG3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecBCD enzyme subunit RecC</fullName>
            <ecNumber evidence="6">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exonuclease V subunit RecC</fullName>
            <shortName evidence="6">ExoV subunit RecC</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Helicase/nuclease RecBCD subunit RecC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recC</name>
        <name evidence="8" type="ordered locus">BPSL1282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RecC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204976.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107903.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1282"/>
    <dbReference type="EnsemblBacteria" id="CAH35276">
        <property type="protein sequence ID" value="CAH35276"/>
        <property type="gene ID" value="BPSL1282"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1282"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.226"/>
    <dbReference type="eggNOG" id="COG1330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SFDLMQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01486">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006697">
        <property type="entry name" value="RecC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041500">
        <property type="entry name" value="RecC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17946">
        <property type="entry name" value="RecC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000980">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01450">
        <property type="entry name" value="recC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecC_C" evidence="7">
        <location>
            <begin position="810"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1114" mass="120326" checksum="FE918415B12E5FEB" modified="2004-10-25" version="1">MLHLFYSNRHETLADALLDDLAFASDGAGPWAAQQVIVPSAALRRRLELDLAKRHGVCANVRFSYLAQWLWAQIGEVLTVPAHSPFAPDRLVWRCYRLLSDHGAAPWRASPRLAAYLAAADAPMRHELAHRIATVFDHYLTYRPEWLAQWQDGESIFALEGAPRHGGEAARDDEAWQAALWRALLAELSDSGMPPAHRFLREARAFDPDVIARARAKWPDAVSVFALPTMPPLHIALLRELSRWIDVRIYALSPCREFWFDIVTAARAESLDAADRLDYQEVGHPLLAEWGRQTQAQLHMLHELTESAAASDASRYADNPAPTWLARVQNAILDLQPEAALGEPPAERGVEVHVCHSLARQLEVLHDRLLAWFDADPNLAPSDVLVAMPDLATAGPLIDAVFGTPAGADAARIPYWITGLPPSQANPVARVLLDWLALPERDVGAPELVEWLRADAVAARYGIDATALETVQTWLAASGARRGLAPDAAEPPNPAVPAPRHTFADALTRLFLGYAMPDGAAPVSTWLPIAGAEGGEAELLGRLARFTDDLDGFARRIARDLTPQGWGDVFADALARFFDSGPAFADALSGVRDALDAMLAAMAEGAAGAALPAAVVRAGLAAALDDPARGGVPWGGVTFSSLTSLRGLPYRIVCLIGMDDGVLPSLARADEFDLMAVFAKLGDRQRRDDERNLFLDLLLAARERLLIAYTGRSIRDNAPLPPAALVDELLDHLAAASAGPDAPPDAVDAARRAFVIEHPLQPFSAEYFAPGGALFTYDASRATLARLLAEGARAQARPFFAAPLPAEPEQPVAFADFERFWRHPARSLLRARLGIVLLDAQAELVDTEPFELDYAGSDALAERVLPLLIETADAAAFEHALRVADASPEVPGGATGAVRRDHALDALAQLAGNVRRALADGATRVPFAFDVAPAWPAASDARWFGEHDAALAAAATREPLRLHGALARLTAAGQVIYRYARPGARDYLAAWLAHLVYCAIDPGGPRRTLWFGSGDTFEFAPVAAPLEQLAPLAALFRAGRRMPLAFFPRSAWALVSESESKAAGVWINDRVAGEADDASLALAWRGANPSLDEPFGALAHLVFDPLVEHLRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VR2</accession>
    <name>Q63VR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533660.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107804.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1182"/>
    <dbReference type="EnsemblBacteria" id="CAH35177">
        <property type="protein sequence ID" value="CAH35177"/>
        <property type="gene ID" value="BPSL1182"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1182"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.349"/>
    <dbReference type="eggNOG" id="COG3803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YMPYMHS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="213" mass="22824" checksum="767DE1704C6146D4" modified="2004-10-25" version="1">MTAPHASDGTREAAARERAALDSRAREVLDFWFGAPDDPAFGTARPMWFGGAPALDAQLRERFGALADAAKAGELDAWAGTPLGALALIVVLDQFPRNIHRGTPLAFAADRAALAHAKALVASGGDRALPTGHHRAFAYLPFEHDESPDSQREAVRLCAQIKDEAGCAGYHDYALRHAVVIERFGRFPHRNAILGRASTDAEAAFLKEPGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VR3</accession>
    <name>Q63VR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative alanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186399.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107803.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1181"/>
    <dbReference type="EnsemblBacteria" id="CAH35176">
        <property type="protein sequence ID" value="CAH35176"/>
        <property type="gene ID" value="BPSL1181"/>
    </dbReference>
    <dbReference type="GeneID" id="56595113"/>
    <dbReference type="KEGG" id="bps:BPSL1181"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.350"/>
    <dbReference type="eggNOG" id="COG2872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMRLHTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="243" mass="25981" checksum="8D26B9335D7A4818" modified="2004-10-25" version="1">MATQALFREDAYLTRCDALVTAVDEAGIHLDRTVFYPLGGGQAGDSGTLTLAGGAALAVADTRKAKFDGATPDDAVHVLAPGQAALAAGVKPGDALVAEIDWAPRHRRMRLHTASHLLCAVLPYPVDGCSVTADYVRIDFATVEPIDREHVQARLAELVGGAHPVTTEWITDDEMVARPELVRTMSVKPPMGLGRVRLLRIEGVDLQPCGGTHVRNTAEIGALRVAKLEKKSARTRRLVLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU2</accession>
    <name>Q63VU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107774.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1153"/>
    <dbReference type="EnsemblBacteria" id="CAH35147">
        <property type="protein sequence ID" value="CAH35147"/>
        <property type="gene ID" value="BPSL1153"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1153"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1270"/>
    <dbReference type="OMA" id="ILQYELN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="7416" checksum="1276F9DA3950FF97" modified="2004-10-25" version="1">MRAMRDANMIDALRYALAKQVPDMEHGFVIQTNYGDLVIDAEDADHFAALARVILGNKLARAEVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VZ1</accession>
    <name>Q63VZ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative electron transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004541633.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107725.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1104"/>
    <dbReference type="EnsemblBacteria" id="CAH35097">
        <property type="protein sequence ID" value="CAH35097"/>
        <property type="gene ID" value="BPSL1104"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1104"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.451"/>
    <dbReference type="eggNOG" id="COG2878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IDEAWCI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016463">
        <property type="entry name" value="RnfB/RsxB_Proteobac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42859:SF3">
        <property type="entry name" value="PTHR42859:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="30100" checksum="6113B42E3A451B8C" modified="2004-10-25" version="1">MTDSKTLADRIEDLLPQTQCTKCGYDGCRPYAEAIAAGTAGYDQCPPGGAEGVARLAKLLGKPVIPLNQAHGVERARPVAFIDEQLCIGCTLCMQACPVDAIVGAPKQMHTIVAELCTGCDLCVPPCPVDCIAMIPVTGERTGWDAWSQQQADAARARHDARAARLKREREAAEARAAARRAASAAAAHAPASSAAAPAAPAADDADAKKRAIIAAALERARKKKEALAAQGAGPKNTEGVSAAVQAQIDAAEARRRRLAEQRDAADEPGRPDDANAAGDDASPPSKTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W50</accession>
    <name>Q63W50_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192556.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107666.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1039"/>
    <dbReference type="EnsemblBacteria" id="CAH35035">
        <property type="protein sequence ID" value="CAH35035"/>
        <property type="gene ID" value="BPSL1039"/>
    </dbReference>
    <dbReference type="GeneID" id="56596151"/>
    <dbReference type="KEGG" id="bps:BPSL1039"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.527"/>
    <dbReference type="eggNOG" id="COG4986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="384"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="585" mass="64977" checksum="70C151C2E62DC4BE" modified="2004-10-25" version="1">MDLGFFDPNRTANASAWRVLPNRWDFVAFPLIICVIAMAAIGFHETMAPIATLETQRISLDPANLPEYALRTTLRMLAAMVAALAFTLVYGTLAAKSRRAGMVLVPILDILQSVPVLGYISFTVTFFLALIPSRVLGAELAAIFAIFTSQAWNMTFSFYQSLRTVPRDLDEVSRGFHLTAWQRFWKLEVPFSMPGLIWNMMMSMSGGWFFVVASEAITVGNHTITLPGIGAYLAQAIVEKNLGAVGWVILAMTVVILAYDQLLFRPLVAWADKFRMETTSSGNAPESWLLDLVRRTRLIHQLLVPAGWFFARLARIPLRVPSLDAVRFSMPRVEKKASRAADIAWAIAVIVGTVYVVWRVFAYVSTGVTLAEVGHVFVLGLITLLRVALLIAIASLVWVPIGVWIGLRPAIAEKVQPLAQFLAAFPANLLFPVFVIVIARFHLNADIWLSPLIVLGTQWYILFNVIAGATAYPNDYREAATNFRIRGWQWWRQAILPGIFPYYVTGAITASGGAWNASIVSEFVQWGDTKIEAHGLGAYIAQTTAAGDYPKIILGIAVMSLFVTLFNRLLWRPLYAYAEAKLRLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB7</accession>
    <name>LGT_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt</name>
        <name type="ordered locus">BPSL0971</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191241.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107599.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WB7"/>
    <dbReference type="SMR" id="Q63WB7"/>
    <dbReference type="STRING" id="272560.BPSL0971"/>
    <dbReference type="EnsemblBacteria" id="CAH34967">
        <property type="protein sequence ID" value="CAH34967"/>
        <property type="gene ID" value="BPSL0971"/>
    </dbReference>
    <dbReference type="GeneID" id="56596220"/>
    <dbReference type="KEGG" id="bps:BPSL0971"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.603"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172574" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <sequence length="296" mass="33095" checksum="108BE364E9AC3CAD" modified="2004-10-25" version="1">MIIHPNFDPVAIHLGPLAVRWYGLMYLVGFILAIVVGRLRLKLPHVAAQGWSAKDIDDMMFYGVLGVVLGGRLGYVLFYKAGYYFSHPLDIFRVWEGGMSFHGGFLGVTLAMALFAWQRKRHWLEVTDFVAPMVPTGLAAGRLGNFINGELWGRVTSPDAPWAMLFPGASRDDAAWLAAHQDIAAKWNLNEVFLSHQMLPRHPSQLYEIALEGIALFFVLWFFSRKPRPMGAISALFLIGYGAARFTVEFAREPDDFLGLLTFGLSMGQWLSLPMIVAGVLMMIWAYRRGGVAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WG2</accession>
    <name>Q63WG2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ordered locus">BPSL0926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526293.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107554.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0926"/>
    <dbReference type="EnsemblBacteria" id="CAH34921">
        <property type="protein sequence ID" value="CAH34921"/>
        <property type="gene ID" value="BPSL0926"/>
    </dbReference>
    <dbReference type="GeneID" id="56526892"/>
    <dbReference type="KEGG" id="bps:BPSL0926"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.654"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FWGWQAH"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="394" mass="42892" checksum="A3FE940F2F2DDD78" modified="2004-10-25" version="1">MPLNDYPIDSLMYITNRPDIVFTHGKGSWLYDHTGKRYLDFIQGWAVNCLGHCNEGLVQALQAQAEKLLNPSPAFYNEPMAKLAGLLTQHSVFDKVFFANSGAEANEGAIKLARKWGRKFRNGAYEIITFDHSFHGRTLATMSASGKAGWDTIYAPQVPGFPKAEINDINSVERLINDKTVAVMLEPIQGEGGVIPATREFMQQLRALTKQHDLLLIVDEVQSGCGRAGTLFAYELAGVEPDIMTLGKGIGGGVPLAALLSKADVAVFEAGDQGGTYNGNPLMSAAGHAVISQLVAPGFLEGVRARGEYLKHKLLELSEERGFEGERGEGLLRALLLGKDIGPQIVEKARDMQPDGLLLNAARPNLLRFMPALNVTNDEIDQMMAMLRSVLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X02</accession>
    <name>Q63X02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526199.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107364.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0738"/>
    <dbReference type="DNASU" id="3092126"/>
    <dbReference type="EnsemblBacteria" id="CAH34730">
        <property type="protein sequence ID" value="CAH34730"/>
        <property type="gene ID" value="BPSL0738"/>
    </dbReference>
    <dbReference type="GeneID" id="56527055"/>
    <dbReference type="KEGG" id="bps:BPSL0738"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.867"/>
    <dbReference type="eggNOG" id="ENOG5032BM4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SQWRGYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021352">
        <property type="entry name" value="DUF2971"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11185">
        <property type="entry name" value="DUF2971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="31697" checksum="EF4EC5C83E104A03" modified="2004-10-25" version="1">MTTASTVYHYCGAESFFSIVRNGRLWVSDARKTNDRRELEWFKDLALKHIAKSAATGDKMLSDLHLALKVRFELLEDVSDYYVCCFSEKKDSVPQWVAYADRGTGFAIGFDVNALRKKIGAALLSPSYAPVPFGVGANGWGFGPVAYAEEGVANAQIDDLMSTIVSAPFVGEDVTDSARDHIDRVCAFCKHPDFQTEHEWRIVCNTSFLKKNAGLTGTDMLPDTKWRKGGYGLTPYRETVDVLDCVKEVIVGPGNADRDSIEYVKQFLRFSGVKAEVFLSVSPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X71</accession>
    <name>Q63X71_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107295.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0666"/>
    <dbReference type="EnsemblBacteria" id="CAH34659">
        <property type="protein sequence ID" value="CAH34659"/>
        <property type="gene ID" value="BPSL0666"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0666"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.954"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EHQICLE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="187" mass="20189" checksum="9FE1CD81BD6F3BE9" modified="2004-10-25" version="1">MPTSLSKKLVVLDRDGVINVDSDAFIKSPDEWIPLPGSLEAIARLNHAGYRVVVATNQSGIGRGLFDMATLNAMHLKMHRAAAAVGGRIDAVFFCPHTADDHCDCRKPKPGMMKLIAERFEIDPADTPVVGDSLRDLQAGEALGFRPHLVLTGKGKKALAAGGLPEGTRVHDDLRAFALDFLSEEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X73</accession>
    <name>Q63X73_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107293.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0664"/>
    <dbReference type="EnsemblBacteria" id="CAH34657">
        <property type="protein sequence ID" value="CAH34657"/>
        <property type="gene ID" value="BPSL0664"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0664"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.723"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLNWRLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="2">
        <location>
            <begin position="64"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="31209" checksum="26D3642E9904E4F0" modified="2004-10-25" version="1">MALDHRQLDLPLFDGPAASPSPASPPAAPPASSATPPEADRSRRRTVALDGRALEYKLKRSARRTIGFAIDGSGLTITAPRWVTLADIEAAIAEKRRWIFNKLAEWQTRAEQRALPQIDWKEGAQIPYLGKPVSIALASAKGALSFDPLAATLELGLPAHASEQQIKDRVQGWLQGEAKRIFGERLVVYAEKLGVTYSMYALSSAATRWGSCSSDGKIRLNWRLIHFPMSIVDYVVAHELSHLREMNHSPAFWQTVESIFPEFREARHTLKHHPPELLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X83</accession>
    <name>Q63X83_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107283.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0654"/>
    <dbReference type="EnsemblBacteria" id="CAH34647">
        <property type="protein sequence ID" value="CAH34647"/>
        <property type="gene ID" value="BPSL0654"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0654"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.711"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDEMAFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="137" mass="14793" checksum="1B1F67EA617C4616" modified="2004-10-25" version="1">MEASIMTDSPMQLPQKPPALRVVPQPSDANVHGDVFGGWIMAQVDVAGSIPASRRANGRVATVAVNSFLFKQPVFVGDLLSFYASIVKTGNTSVTVDVEVYAQRMSLMSEIVKVTEATLTYVATDSDRRPRALPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X87</accession>
    <name>Q63X87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 3-ketoacyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537877.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107279.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0650"/>
    <dbReference type="EnsemblBacteria" id="CAH34643">
        <property type="protein sequence ID" value="CAH34643"/>
        <property type="gene ID" value="BPSL0650"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0650"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.972"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYYWGMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="276"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="399" mass="41985" checksum="7ED9FA93DCC36C05" modified="2004-10-25" version="1">MSKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPEFDTKLIEDAIVGCAIPEAEQGLNVARMGALLAGLPNTVGGVTVNRFCASGITALAMAADRIRVGESDALLAAGVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERVAEQWKVSREDQDAFSVESHRKAIAAQQAGEFKDEIAPYAIVERFPNLATGEIDTKTREIALDEGPRAETSLEGLAKLKTVFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWIELNEAFAAQSLAVIRDLGLDPSKVNPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XA7</accession>
    <name>Q63XA7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RpiR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190155.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107258.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0629"/>
    <dbReference type="EnsemblBacteria" id="CAH34622">
        <property type="protein sequence ID" value="CAH34622"/>
        <property type="gene ID" value="BPSL0629"/>
    </dbReference>
    <dbReference type="GeneID" id="56596678"/>
    <dbReference type="KEGG" id="bps:BPSL0629"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.995"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYAMLAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="130"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="31770" checksum="FDD68C504B8896A2" modified="2004-10-25" version="1">MTPFAEQPAFDIVARIAECAPELRDAERKVAALILGDLAQAAHASIGALAARADVSVATVTRFAKAVGCRDVRELKLRLAQAAAVGQRFLAPAAADAQRDETPVSRVYEDVRIALEHNHRLLRQTSFDAAAAALAAANMIYVYGQGGGSTALADELRFRLVRFGRPVASYQDALLQRMVAATAAPGCVVVALSVSGRVPEQLESCALAKRYGATLVALTAPASPLAQLADHLIPVVAFETDFIFKPSTSRYAMLMALDVLVTEVALRLGDDCRELLRRMKHALDMHRGGGERQPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR2</accession>
    <name>Q63XR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522893.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107103.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0478"/>
    <dbReference type="EnsemblBacteria" id="CAH34467">
        <property type="protein sequence ID" value="CAH34467"/>
        <property type="gene ID" value="BPSL0478"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0478"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1177"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVWFSLE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="363" mass="39166" checksum="7197D5CA5B7807D6" modified="2004-10-25" version="1">MLEVFLILTRNELLGQLRSKARLFWTFVFPILLMSVMLVAFGKHSSLGVVELAFDGNAAAPQARACRAAIEAAFAGNGTVGARVVAPNAAGAAGGDRVRVSWPARAADPVRVSYDFNGPLAARAAARTIEIALVRCAASEAGLPAAYQVRFENDGHALAPLDYGEFFATGILIMAFMSIGVVSTATTIATLRERNTFKMYVCFPVSRFVFLASLIVSRVILMLAASVTLMLAARYLFQVPLPLWSLRALRAIPVVLLGAAMLLSLGTLLASRARSLAAAEAWCNLIYFPLLFFSDLTIPLRAAPHWLRVVLLVLPTNQFAVALRGVFVRDLGYAQAAWPLAVVAGWTLVFLAGAALTFRWHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XR5</accession>
    <name>Q63XR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107100.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0475"/>
    <dbReference type="EnsemblBacteria" id="CAH34464">
        <property type="protein sequence ID" value="CAH34464"/>
        <property type="gene ID" value="BPSL0475"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0475"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.533"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVARSWQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="38859" checksum="FA1BDF9ACD7A4F7D" modified="2004-10-25" version="1">MSSGIAPPHSVNYRKKYATEAHALSAIRPWRCAWVIARQWIGIAIAFALPIALVARLTGGTSLAHAFAALGAPQRLGVAAALGAAYVYLACKQHALGIVMHDATHFRLFESRRVNELVGNWLCAFPIGMVTSCYRRSHLPHHLFTNKPNDPYWARLVEDAHYAFPMSRAAFGRILLGDVFGANLRAWWPTLRSWTGWSSVLDNREKLLTPSERRQFVAFWIGALALAAYFGVLSYFLLLWVLPMFTLSLAFIRLRVIAEHDLEKAGHELERTRHVDGGWFERLAIAPLNINYHVAHHLFPSVPLYNLPKMHALLMQEPAFREHAQLWRSYLGRKHGMVRSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XZ8</accession>
    <name>Q63XZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525985.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107017.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63XZ8"/>
    <dbReference type="STRING" id="272560.BPSL0391"/>
    <dbReference type="EnsemblBacteria" id="CAH34379">
        <property type="protein sequence ID" value="CAH34379"/>
        <property type="gene ID" value="BPSL0391"/>
    </dbReference>
    <dbReference type="GeneID" id="56527365"/>
    <dbReference type="KEGG" id="bps:BPSL0391"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1275"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRVWHEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="29660" checksum="BE810BC17FB9B5D5" modified="2004-10-25" version="1">MTDLALYAGYEALRIQRRPHGIVEIVMSGEGANRSGLAVASEAMHRELADIWRDVDRDPDARVAVIRGEGKGFSAGGDLALVERMADAHAVRERVWREARDLVYNVINCSKPIVSAMHGPAVGAGLVAGLLADVSIAAKHARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYHLLLCEPVSGEEAERIGLVSLALDDHELLPKAYEIAERLAQGSQSAIRWTKYALNNWLRLAGPTFDASLALEFMGFSGPDVREGIRSLRERRAPDFTGGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XZ9</accession>
    <name>Q63XZ9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ureidoglycolatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Ureidoglycolate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL0390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536264.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107016.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0390"/>
    <dbReference type="EnsemblBacteria" id="CAH34378">
        <property type="protein sequence ID" value="CAH34378"/>
        <property type="gene ID" value="BPSL0390"/>
    </dbReference>
    <dbReference type="GeneID" id="56527366"/>
    <dbReference type="KEGG" id="bps:BPSL0390"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1277"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QLIAHIC"/>
    <dbReference type="UniPathway" id="UPA00394"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041072">
        <property type="entry name" value="FAA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18288">
        <property type="entry name" value="FAA_hydro_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydro_N_2" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="83"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="330" mass="35954" checksum="414F9886C8EA17AD" modified="2004-10-25" version="1">MKLASLKDGTRDGQLIVVSRDLHTAAIADAIAPTLQRVLDDWAFYAPQLRDLYDALNHGRARNAFAFEPADCMAPLPRAFQWADGSAYVNHVELVRRARGAEMPPEFWTDPLMYQGGSDDFLGPRDDIVCASEAWGIDFEAEVAVITADVPMGAAPDEALKAVRLVTLVNDVSLRNLIPAELAKGFGFFQSKPASAFAPVAVTPDELGEHWREGRLHRPMLVHWNGKKVGQPDAGVDMVFHFGQLIAHAAKTRNVRAGSIVGSGTVSNKDAKRGYCCIAEKRCLETIEHGAPQTEFMRYGDRVKIEMVDEAGKSIFGAIEQAVAPLDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y27</accession>
    <name>Q63Y27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106988.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0362"/>
    <dbReference type="EnsemblBacteria" id="CAH34350">
        <property type="protein sequence ID" value="CAH34350"/>
        <property type="gene ID" value="BPSL0362"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0362"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.408"/>
    <dbReference type="eggNOG" id="ENOG5031AZ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WDVAGQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267689" evidence="2">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="268" mass="28438" checksum="A4AAABD6D2CA56EF" modified="2004-10-25" version="1">MKLDAVRRACAALGGAAVLAAAPALAAPPAPDGGRAPDLDAVLLHESMAVSADGVTRTVTYRERMVRRDGHVWIERVPPSGAKRAHAGGAHAHEGLDAARTPPSRGGAHPAAAAADAHAGHRHFDFDSAARHVTNDGGRIGVEYVDAAQRTVVAVPPAEYETTGFDGSWDNAFYITPPSQLKRLAAQSKPGPAPGTRWYEQTVGAPRAQGTNRVLWSDALQAPLVVEYRSADGHASRKLTLTPAPRANALPWRQLQSYTRKAYADYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y90</accession>
    <name>Q63Y90_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Argininosuccinate synthase</fullName>
            <ecNumber evidence="6 15">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">argG</name>
        <name evidence="16" type="ordered locus">BPSL0298</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the argininosuccinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="6 15"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189990.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106925.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63Y90"/>
    <dbReference type="STRING" id="272560.BPSL0298"/>
    <dbReference type="EnsemblBacteria" id="CAH34287">
        <property type="protein sequence ID" value="CAH34287"/>
        <property type="gene ID" value="BPSL0298"/>
    </dbReference>
    <dbReference type="GeneID" id="56594668"/>
    <dbReference type="KEGG" id="bps:BPSL0298"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1396"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRAYFNT"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00581">
        <property type="entry name" value="Arg_succ_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023437">
        <property type="entry name" value="Arg_succ_synth_type2_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024073">
        <property type="entry name" value="AS_multimer_C_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="446" mass="49697" checksum="4CCD1D69BF896599" modified="2004-10-25" version="1">MTTILENLPAGQKVGIAFSGGLDTSAALHWMRIKGAVPYAYTANLGQPDEDDYDAIPKRAIQYGAEGARLIDCRAQLVAEGIAALQCGAFHISTAGVTYFNTTPIGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLVNPDLKIYKPWLDQQFIDELGGRAEMSEFMRQAGFEYKMSAEKAYSTDSNLLGATHEAKDLESLESGIKIVNPIMGVAFWRDDVKIDKEEVTIRFEEGRPVALNGVEYKDAVALLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLYIAYERLVTGIHNEDTIEQYRENGRRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGEVTVELRRGNDYSIIGTRSPNLTYQPERLSMEKVQSMFSPRDRIGQLTMRNLDITDTRDKLRIYSQVGLLAAGESSALPKLKEDESGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YD4</accession>
    <name>Q63YD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106881.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0254"/>
    <dbReference type="DNASU" id="3094107"/>
    <dbReference type="EnsemblBacteria" id="CAH34242">
        <property type="protein sequence ID" value="CAH34242"/>
        <property type="gene ID" value="BPSL0254"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0254"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.272"/>
    <dbReference type="eggNOG" id="COG3735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QTMISWW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266427" evidence="1">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="342" mass="36408" checksum="716049C362B665E9" modified="2004-10-25" version="1">MLAGACATGGLAWPPAGALAAGSVAAAPLPQAPIPAPSMSLPGFHAPPPSTSNGTVASGAVRTQPARMPFYVATKGKVTIYVLGTLHVGDPADYPANQPFRRPILAALAASPTLALELSPDDLLESQDDVSKYGVCNYACLPRLLPPPLWQKLANRLRGNPAALAGIRNMRPWLASLVVETYDSLSAGLQTEYGTEAQLQNVFLRKKGGKVVGLETLAEQMRAFTGLTLAQQREMLAQDMVQTPAQNAADVRALHRLWRIGDADAIAAWANAKTERLARARSIADSIDNKIVYERNRRFVARMTAIAAPNRPLFVAIGSLHLGGPKGVLELLRQQGYRVDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YE7</accession>
    <name>Q63YE7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="4">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fpr</name>
        <name evidence="7" type="ordered locus">BPSL0241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197182.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106868.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0241"/>
    <dbReference type="EnsemblBacteria" id="CAH34229">
        <property type="protein sequence ID" value="CAH34229"/>
        <property type="gene ID" value="BPSL0241"/>
    </dbReference>
    <dbReference type="GeneID" id="56594410"/>
    <dbReference type="KEGG" id="bps:BPSL0241"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1471"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MICGSSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06195">
        <property type="entry name" value="FNR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033892">
        <property type="entry name" value="FNR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="28830" checksum="2CF6882B572F9301" modified="2004-10-25" version="1">MSKFDTATVLSVHHWTDTLFSFTCTRDQALRFNNGEFTMVGLEVDGKPLTRAYSIVSPNYEEHLEFFSIKVQNGPLTSRLQHLKVGDPVLIGKKPTGTLVADNLLPGKTLWLLSTGTGLAPFMSIIRDPDIYERFEKVVLTHTCRLKGELAYMDYIKHDLPGHEYLGDVIREKLVYYPTVTREEFENEGRITDLIASGKLFTDLDVPPFSPERDRVMLCGSTAMLKDTTELLKKAGLVEGKNSAPGHYVIERAFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YU9</accession>
    <name>Q63YU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106716.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0090"/>
    <dbReference type="EnsemblBacteria" id="CAH34074">
        <property type="protein sequence ID" value="CAH34074"/>
        <property type="gene ID" value="BPSL0090"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0090"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.101"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMADWAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="102"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="276" mass="31593" checksum="D053F3EB85C73BF0" modified="2004-10-25" version="1">MAIREKVNISERRACRLVGLSRSVLHYDAKPDHENEVLAARLVKLAHERRRFGYRRLHALVEREGTHANHKRIYRLYREAGLAVRRRRKRHGVMIEREQLALPGAPNEVWSIDFVMDALSNGRRVKCLTVVDDFTKEAVDIVVDHGISGLYVARALDRAARFRGYPKAVRTDQGPEFTSRALDQWAYANGVTLKLIQAGKPTQNAYIESFNGKFRDECLNEHWFTTLAHARAVIAAWRQDYNEQRPHSALNYLAPSEFAAKHRATADAPAAFQELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z28</accession>
    <name>Q63Z28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General secretory pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gspF</name>
        <name evidence="9" type="ordered locus">BPSL0009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196821.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106634.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0009"/>
    <dbReference type="EnsemblBacteria" id="CAH33992">
        <property type="protein sequence ID" value="CAH33992"/>
        <property type="gene ID" value="BPSL0009"/>
    </dbReference>
    <dbReference type="GeneID" id="56594180"/>
    <dbReference type="KEGG" id="bps:BPSL0009"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1739"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VAEQCEK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011850">
        <property type="entry name" value="T2SS_GspF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02120">
        <property type="entry name" value="GspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="72"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="274"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="405" mass="44102" checksum="369427296C77EE73" modified="2004-10-25" version="1">MPAFRFEAIDASGRAQKGVIEADSARNARGQLRTQGLTPLVVEPAASAQRGARSQRLALGRKLSQREQAILTRQLASLLVAGLPLDEALAVLTEQAERDYIRELMAAIRAEVLGGHSLANALTQHPRDFPEIYRALVAAGEHTGKLGIVLSRLADYIEERNALKQKILLAFTYPAIVTVIAFGIVTFLLSYVVPQVVNVFASTKQQLPVLTIVMMALSDFVRHWWWAILIGIAAVVYLVKATLSRDGPRLAFDRWLLTAPLAGKLVRGYNTVRFASTLGILTAAGVPILRALQAAGETLSNRAMRGNIDDAIVRVREGSALSRALNNVKTFPPVLVHLIRSGEATGDVTTMLDRAAEGESRELERRTMFLTSLLEPLLILAMGGIVLVIVLAVMLPIIELNNMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H7C738</accession>
    <name>H7C738_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Acyl-homoserine-lactone synthase</fullName>
            <ecNumber evidence="2 7">2.3.1.184</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autoinducer synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pmlI</name>
        <name evidence="8" type="ordered locus">BPSS0885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:10096"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:55474"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.184"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the autoinducer synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.184" evidence="2 7"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523992.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110894.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0885"/>
    <dbReference type="EnsemblBacteria" id="CAH38347">
        <property type="protein sequence ID" value="CAH38347"/>
        <property type="gene ID" value="BPSS0885"/>
    </dbReference>
    <dbReference type="GeneID" id="56530660"/>
    <dbReference type="KEGG" id="bps:BPSS0885"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7177"/>
    <dbReference type="eggNOG" id="COG3916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPGNAEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061579">
        <property type="term" value="F:N-acyl homoserine lactone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018311">
        <property type="entry name" value="Autoind_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001690">
        <property type="entry name" value="Autoind_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39322">
        <property type="entry name" value="PTHR39322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00765">
        <property type="entry name" value="Autoind_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01549">
        <property type="entry name" value="AUTOINDCRSYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00949">
        <property type="entry name" value="AUTOINDUCER_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51187">
        <property type="entry name" value="AUTOINDUCER_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="3 6 7" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="203" mass="22214" checksum="181E3CDE4E495E46" modified="2012-04-18" version="1">MRTFVHGDGRLPSDLAADLGLYRHRVFVEQLGWKLPSASEGFERDQYDRDDTVYVFARDDDGEICGCARLLPTTRPYLLKELFPTLVAQDMPLPQSAAVWELSRFAANAEDPAGGGNPAWAVRPMLAAVVECAARLGAKQLIGVTFLSMERLFRRIGVHAHRAGPAQQIDGRMVVACWIDLDAQTLAALDLDPLLCAPPAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>H7C766</accession>
    <name>H7C766_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524349.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111420.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1408"/>
    <dbReference type="EnsemblBacteria" id="CAH38883">
        <property type="protein sequence ID" value="CAH38883"/>
        <property type="gene ID" value="BPSS1408"/>
    </dbReference>
    <dbReference type="GeneID" id="56530171"/>
    <dbReference type="KEGG" id="bps:BPSS1408"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4732"/>
    <dbReference type="eggNOG" id="ENOG50343F9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYAKDFN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="82" mass="8833" checksum="C80E7E7D41C1F642" modified="2012-04-18" version="1">MYEPLEPFAQDFNEVRTLLDDPAGGDRLRELCAAIEAVAERLGAAPAATELDRSNLAKLYRGFLATSRVLAGLQETARAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I56</accession>
    <name>Q63I56_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">katE</name>
        <name evidence="17" type="ordered locus">BPSS2214</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529427.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112216.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2214"/>
    <dbReference type="EnsemblBacteria" id="CAH39699">
        <property type="protein sequence ID" value="CAH39699"/>
        <property type="gene ID" value="BPSS2214"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2214"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5803"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRGDNEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="43"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAH39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="708" mass="78332" checksum="7F7955E042421ED3" modified="2004-10-25" version="1">MADSDRNAPHETPRAAQPDDARADRKSQDLEPYRSKPQGEALRTNQGVRIADDQNTLRAGARGPSLLEDFIMREKITHFDHERIPERVVHARGSAAHGVFRVYESMAEYTKAAFLQDPAKETPVYVRFSTVQGPRGSADTVRDVRGFAVKFYTDEGNYDLVGNNMPVFFIQDAIKFPDFVHAVKPEAPNEMPTGASAHDTFWDFVSLVPESAHMVAWLMSDRAIPRSFRTMEGFGVHTFRFVNAQGVARFVKLHWRPVLGSYSLLWDEAQKIAGHDPDFHRRDLWEAIERGDYPEYELGVQIIEARDQHAFGFDLLDPTKLIPEETVPVKLIGKMTLNRNPDNFFAETEQVAFHPGHLVPGIDFTDDPLLQGRLFSYTDTQLSRLGGPNFHELPINRPVCPFANLQRDAMHRQTIDVGQASYEPNSLNGGWPKETDPAGRDGGFDSYPEAVEGAKVRVRSGSFADHFSQAALFYQSMSDVERRHIRDAYRFELGKVTRPEIRARVVDEILARFDAGLAAEVAEGLGLPPPPTSAPAIVAQPLSPALSLLTRGKRSVRSRKVALVATPGADTRLIERVRRALTDARAVPVLVAPTLARIGELTPEATLAGMPSVMFDAVFVCGGDGDGRDLVHSSDARHFLQEAFKHLKAIAAVGSGRQLLGAAHLPEQGDGVCVGHAADLDQVVAKFFDALSEHRVWSREPLAQGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IH7</accession>
    <name>Q63IH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524812.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112095.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2096"/>
    <dbReference type="EnsemblBacteria" id="CAH39576">
        <property type="protein sequence ID" value="CAH39576"/>
        <property type="gene ID" value="BPSS2096"/>
    </dbReference>
    <dbReference type="GeneID" id="56531810"/>
    <dbReference type="KEGG" id="bps:BPSS2096"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5639"/>
    <dbReference type="eggNOG" id="COG3519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEYHVVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028304">
        <property type="entry name" value="UCP028304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="623" mass="68673" checksum="C9468C5D317B9B4F" modified="2004-10-25" version="1">MDTRLLDYYNRELAYLRELGGEFAQQFPKVAARLRMHESGPPDPYVERLLEGFSFLTARVQLKMDAEFPRFTQALLDAVYPGYVAPLPSMAIVQFTPMMNEGSLAQGYRLPAGTALRARPAAAEQTACEFRTAHDLTLWPLELAGASVTGAPAYLPRSATAARRDVRGALRIRLKARGGAGLAQLPIDRLMFHLAGPERDALHLLELIAGHTIGVVCHDAAQPPRWLHALGAHALAHQGFDADQALLPDEGRSFHGYRLLREYFAFPARFLFFSIEGLRPALARATGDTFELTLLLDRHDAALENSVDARHLALNCTPAVNLFARRADRIPVHPGAREHHVVVDRSRPLDYEVYAVRRLAGEQRDDGQMRAFRPFHASFAGDGGNYGAYYTVRREPRLVSAQARANGTRTGYVGSETFVSLVDSACAPYDESIRYLSVDTLCTNRDLVLLLPAGDANAFTLRVSAPVERIAMIRGPSRPRPPLADAQSAWRLVSHLGLARHTLTDVDDEEGARVLRELLGLHADPADAAMRRQIDGVHRVAFAPVFRRLPAAGPLMFGRGVQVDVTVDDHAFSGDSPYLLGAVLEQFFARHVSINSFAECVLSSAQRGRLAQWPARVGRRPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IM7</accession>
    <name>Q63IM7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative inner membrane fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552166.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112045.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2042"/>
    <dbReference type="EnsemblBacteria" id="CAH39520">
        <property type="protein sequence ID" value="CAH39520"/>
        <property type="gene ID" value="BPSS2042"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2042"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5574"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRRPQRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="617" mass="66521" checksum="6578513A37CCC508" modified="2004-10-25" version="1">MTHPRETTAADTFADFVELTRYRAAHQPDLPVYTFVTGGDRDERPLTCAQLDRRASAVAAALSEIARPGERVLLLFAPGIDYIAALFGCMYAGVVAVPAYPVEPAQPERTLRRLLGIVADCAPAAVLSTAAVRDGMNRVETGSPALRGLRWIEIDALSPGDDAAHGAPRAADPRVPVYLQYTSGSTGAPKGVMISHRNLLHNSALIARRFEHGASSRGVIWLPPYHDMGLIGGILQPLYVGFPVTLMSHVDFLKHPLRWLRAIGERRATTSGGPNFAYQMLATMRIADADFDKLDLRSWDVAFVGAEPIRAATLHAFAQRFARCGFDARAFYPCYGLAEHTLFMTGGLKSQPPVVANGPSDARLPRASDHADAPGQADPAGDGRQAGARAAVGCGDAASDSLVLIVDPDTRVPCDDGRVGEIWAQGPSVALGYWNNRALSEQTFEAELPGYAGRFLRTGDYGYRSGSEVFVTGRLKDMMLIRGANHYPHDVEATIEALDAELFRPGGCAVFALDTGAAPQVTVVRELRARYLKAFGDGGQEAGHTPDALFGRLRQAINLHHGIAVHHIVFTSPSAIPKTTSGKVQRHACRELFLNDTLPVVTQWRAPCGAPNDIRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IN4</accession>
    <name>Q63IN4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524880.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112038.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2035"/>
    <dbReference type="EnsemblBacteria" id="CAH39513">
        <property type="protein sequence ID" value="CAH39513"/>
        <property type="gene ID" value="BPSS2035"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2035"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5563"/>
    <dbReference type="eggNOG" id="COG3246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FECFDVG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="31889" checksum="5BD74421D31878AD" modified="2004-10-25" version="1">MNHPVVITCALNGIFTDPKQFNVPVTPEQMAREAKGAYDAGASCMHVHFRRQEPDKGHLPSWDPRLAAEIAQAIREACPGVIFNQSTGIVGPNVDGPLACIRAIRPEIAACNAGSLNYLKVKADGAWAWPPMLFDNPVEKVASFLTTMAETGAVPEFECFDTGIVRCIDMYARAGLFEGRSNYNFVMGVESGMPAEPELLPILTRLLRADSTWQVTAIGRANIWALHRRTAELGGQLRTGLEDTFYLPDGARATSNAQLVDAIAAIAREAGREIASPRDARRILGTRAQAAPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IN5</accession>
    <name>Q63IN5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative acetyl-/propionyl-coenzyme A carboxylase alpha chain protein</fullName>
            <ecNumber evidence="11">6.3.4.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS2034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="11"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004547201.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112037.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2034"/>
    <dbReference type="EnsemblBacteria" id="CAH39512">
        <property type="protein sequence ID" value="CAH39512"/>
        <property type="gene ID" value="BPSS2034"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2034"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5562"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HLMGSKR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="5"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="124"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="590"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="670" mass="71277" checksum="94812E4DAD6EBCC2" modified="2004-10-25" version="1">MSTRRFTRLLIANRGEIAVRIARTARRLGIATIAVHSDADARSPHVAACDDAVAIGGATPAESYLSIDKLIDAALTSGAQAIHPGYGFLSEHAAFARRAAEAGLVFVGPRADAIDAMGDKARARRRMAAAGIAVVPGYDGDDQREARLLSEAERIGFPVMLKAAAGGGGRGMRRVDARDALPGALKRAVSEAQQAFGDGRMIVERAVIEPRHIEVQVFADAHGRIVHLGERDCSVQRRHQKIVEEAPSPAVDAALRERLGATAVAVAREIGYVGAGTVEFLLDREGRFYFMEMNTRLQVEHPVTELITGQDLVEWQLRVAQGDALPLAQQDIRLDGHAIEVRLCAEDPADDFLPRTGSVLTWRPGRHARCDHALADGLAISPFYDSMLGKLIAHGGSRAEAIDRLAHALDDTVLLGVPTNRAFLARVLRHPVFADGRAVSTAFVAAHFPDNDSRRCAPTQAVWAIAAWLSTLAADRADALPGAWRGWRNGAPLPVPYRLSLANANAGADHPDARRGIVTAERQRAVVHAQGGSPIVLDAARPPCPGEPSTVSIDGRAHACCFAIAHGRLWLQVDGVDHAFAIHNREGRASAAAADSDGVLRAPMNGRVIAVDIDEGATVSAGQTVMVLEAMKMEHAITAPFAGRIASLGARPGEQVSPGQVLARLEPQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IQ9</accession>
    <name>Q63IQ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524913.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112013.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2010"/>
    <dbReference type="EnsemblBacteria" id="CAH39488">
        <property type="protein sequence ID" value="CAH39488"/>
        <property type="gene ID" value="BPSS2010"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2010"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5528"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDWNTVA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266068" evidence="1">
        <location>
            <begin position="41"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="373" mass="40770" checksum="AC6EC09B6635A928" modified="2004-10-25" version="1">MNRLALVAAARACAAARLLRRRALRAASLAACGLALCANAAELQLSGYYQRPDGAITVRLNGAGIDPYFAAKALLAASDAQLDARQAARAWIAWLLPRQRADGGFDRFCLKDGQYAACADADADDAMMATWMELLARFAPPGGMPANWARSLARASTHLDALLDKRTGVYQISPTLHVALLMDNVEVHSALQALAAYHIRHADYAHAQPWSQRADRLSAAILQVFWRGAQAGFRASTQQIGDTGFYPEKVAQIFPILSGIRVPDQSNAAIYAQWMHRYGKTWLHLAGTDFPWGLIALVAYKMNDWNTVACWHARSGPYRHGPHWNVLEEALYLAFENRMTDPVAPARCGLATASADFAPRDASARAGIASLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J78</accession>
    <name>Q63J78_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533413.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111844.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1840"/>
    <dbReference type="EnsemblBacteria" id="CAH39316">
        <property type="protein sequence ID" value="CAH39316"/>
        <property type="gene ID" value="BPSS1840"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1840"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5288"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DIKPTRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="344" mass="37543" checksum="292268B82762859F" modified="2004-10-25" version="1">MAEEQQAKIINEGRRGFLARSSAWPVGMLMLPLAGCGDGDGVVPSAHAQDTPPPSGAGYTIDRSIQSPNQDSRVRTLVLHYTAQTLADSIASLTSPQRQVSAHYLVPDAADDGRRFKVFELVPQARRAWHAGVSYWQGDRMLNAGSVGIEIVNLGFPPEDENLPLMNRRWYPYPDAQVAVFGALAADVVAQHQVLPHKVVGHSDVAPGRKTDPGPLFPWKKLYDQYKIGAWPEAEAVDYYRVNRPFAGDVASLQSKLLAYGYDTPQTGTLDAQTVNVVSAFQMHFRPSRYDGVPDVETVAILDALLEKYFNRGRAINKQTLPGATAPTGEKGSDAWPLAPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JN7</accession>
    <name>Q63JN7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative histone-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111685.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1680"/>
    <dbReference type="EnsemblBacteria" id="CAH39153">
        <property type="protein sequence ID" value="CAH39153"/>
        <property type="gene ID" value="BPSS1680"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1680"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5976"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HLETTII"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="140" mass="14520" checksum="1436C94866679C62" modified="2004-10-25" version="1">MAKKAAAPAKKVAAKKAAPAKKVVAKKAVAKAPAAPTPLKDKFTKASLATHIAERAAVEVKAVKAVLAALENVVLGSIHKKGAGEFTLPGLLKITAQAVPAKKKRFGKDPFTGAERWFPAKPASVRVKARALKKLKDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT2</accession>
    <name>Q63JT2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205654.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111640.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1632"/>
    <dbReference type="ESTHER" id="burma-q62ar2.1">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="ESTHER" id="burma-q62ar2.2">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39107">
        <property type="protein sequence ID" value="CAH39107"/>
        <property type="gene ID" value="BPSS1632"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1632"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5917"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DIVSWRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2236"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3328"/>
            <end position="3402"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4401"/>
            <end position="4476"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="5459"/>
            <end position="5534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2115"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3226"/>
            <end position="3254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2122"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3230"/>
            <end position="3254"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1147"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2271"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3363"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4436"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="5494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="6094" mass="664054" checksum="1D34B1C6D7B3B3CA" modified="2004-10-25" version="1">[encoded data, 6094 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JU3</accession>
    <name>Q63JU3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secretion apparatus protein BsaZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSS1621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the bsa type III secretion system, is involved in the intracellular replication of invading bacteria inside the host cell. Probably necessary for the lysis of the vacuole membrane and escape into the host cell cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551930.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111629.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1621"/>
    <dbReference type="MEROPS" id="N06.004"/>
    <dbReference type="EnsemblBacteria" id="CAH39096">
        <property type="protein sequence ID" value="CAH39096"/>
        <property type="gene ID" value="BPSS1621"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1621"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5007"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VALKWDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006307">
        <property type="entry name" value="BsaZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01404">
        <property type="entry name" value="FlhB_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="360" mass="38915" checksum="678046C64DB08AD5" modified="2004-10-25" version="1">MAEEKTEEPTEKKLKKVREKGQVAKSKDIADAMTLAAAIGVLTACESMLTGGLSRAVRTALDFVRGERTPQATLAALHDLAASAALTMLPFVAAAIVAGIVSQAPQAGFLITLEPVMPKFDAINPMAGIKRIFSLKSLLELVKMIVKALVLACVAWKMMTSLFPLVVASVYEATPQLARVLWTVLMKLLGTVSVVVAVLAAADYKIARVMFVRENRMTKEEVKREHKESDGDPHTKGERRRLAREIATSAPPRQRVGQANVLVVNPTHYAVAIRYAPDEHPLPRVIEKAVDDGALALRRHAHALGVPIVGNPSVARALYRVERDASIPEELFETVAAILRWVESLSAARAVAAVSSARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JW4</accession>
    <name>Q63JW4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative type IV pilus biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilN</name>
        <name evidence="3" type="ordered locus">BPSS1600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205650.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111608.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1600"/>
    <dbReference type="EnsemblBacteria" id="CAH39075">
        <property type="protein sequence ID" value="CAH39075"/>
        <property type="gene ID" value="BPSS1600"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1600"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4981"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPWVNLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013359">
        <property type="entry name" value="Pilus_4B_PilN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011514">
        <property type="entry name" value="Secretin_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07655">
        <property type="entry name" value="Secretin_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02520">
        <property type="entry name" value="pilus_B_mal_scr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Secretin_N_2" evidence="2">
        <location>
            <begin position="221"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="589" mass="59923" checksum="4DED65783F435035" modified="2004-10-25" version="1">MRVLFAISLLAVAWLAGCTGLRGGIERDARRDSNETGALLKRASDGDNSVRSLAPVVVDNGLWVSAGTVKLRNSEQLPPLFDEPASFDRSVASLSEFAEQITRLTQVPTQVAASAQQAAARSQHGGAGDAARGAPAFLDASGARAVPPLPPGLPGGASAGGGKTGGGAAGAGSEGGGTSFAPVRVLYAGGTLRGLLDAACARFGVSWKYEQGAIRFFFTDTRTFQVNAIPGDSSLNASVVSGATSDGAAGGSQSGGSGGSGGGINGAGSGTTGLTANNTANTAVNSQLSVFNGLQSAIQSMLSRYGSSVASPATGSISVTDTPDVLERVAAFMAQQNRSLSRQVLLNVTVLSVSLQAGDAYGIDWNLVYKTMSAGFGITNPFHPTALTAPADMSAAVLSPTSRFNGTKLLIRALSQQGTVRRKTSASVTTLNNQPVPVQVATQTGYLASVSTTNTANVGSSTALTPGVVTTGFNMTLLPHVLDDGTVMLQFSTNISSLLELKEVTSSTGGSGLARIQTPDVDMRNFLQRVAMKSGETLVISGYEGANDSLDERGVGTPKMIALGGGYEAQRAREVIVILITPVTQRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JX9</accession>
    <name>Q63JX9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198842.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111593.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39060">
        <property type="protein sequence ID" value="CAH39060"/>
        <property type="gene ID" value="BPSS1585"/>
    </dbReference>
    <dbReference type="GeneID" id="56597936"/>
    <dbReference type="KEGG" id="bps:BPSS1585"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4962"/>
    <dbReference type="eggNOG" id="ENOG5031DD9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMNASEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="16545" checksum="FDB950AF09E6A487" modified="2004-10-25" version="1">MEHGYEHRRRRRLIRWIQALALSALLAIGVTWIGAAVDHPVERAIVDGMAAPECAQVRAMPAGSLLSARQPDSAVCRSFFLYRAAYVDAASNAPGYSAAVMRARVDEFWQLVGYVLALWFVFVCVVVGIVVVVRRRFEQHAGGHHGSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K04</accession>
    <name>Q63K04_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kumamolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528841.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111568.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1562"/>
    <dbReference type="EnsemblBacteria" id="CAH39035">
        <property type="protein sequence ID" value="CAH39035"/>
        <property type="gene ID" value="BPSS1562"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1562"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4927"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASEGWDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S53" evidence="4">
        <location>
            <begin position="176"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="529" mass="53966" checksum="5F992A301E26CD53" modified="2004-10-25" version="1">MARHLHAGNESHLVAESTCIGPCDPAETIHVVVMLRRQQEQHLDSLLQGLASGDPGVKPVSREAFAQRFGAHPDDVMKVEAFAQQRGLAVARVDPVESLVVLSGTIAQFEAAFGVKLERFEHRSIGQYRGRTGDITLPDELHGIVTAVLGLDDRPQARPHFRLRPTFLPARAPAVTYTPPQLAALYDFPPGDGAGQCIAIVELGGGYRPAEIQQYFGGLGLARQPKLVDVSVGAGRNAPTGDPSGPDGEVALDIEIAGAIAPGATIAVYFAQNSDAGFIQAVNQAVHDTTNRPSVVSISWGAAEANWTSQSIQAFDSVLQSAAALGVTVCAASGDDGSNDGLQDGTNHVDFPASSPYVLACGGTRLDALPGQGIRSEVVWNDEAAGGGATGGGVSAVFDVPQWQSGLSATLAQGGGASPLAKRGVPDVAGDASPATGYEVFVAGTSTVMGGTSAVAPLWAALVARINAAAGSPAGWINPKLYRNAGALHDISVGDNGAYAATPGWDACTGLGSPDGAKVAAALKGGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K05</accession>
    <name>Q63K05_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188655.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111567.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1561"/>
    <dbReference type="ESTHER" id="burma-q62ax8">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39034">
        <property type="protein sequence ID" value="CAH39034"/>
        <property type="gene ID" value="BPSS1561"/>
    </dbReference>
    <dbReference type="GeneID" id="56597907"/>
    <dbReference type="KEGG" id="bps:BPSS1561"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4925"/>
    <dbReference type="eggNOG" id="COG2939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MWNVYLN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="554" mass="60163" checksum="9E7E002DE873C494" modified="2004-10-25" version="1">MSIDSTSSGGAQPLHHGANGSVHAPPPVIVAPKDDGDQPFFDPVAYGNGPDDSVTDTTEAAAITHHTVRIDGRTIAYTAAAGHLVTVDPSSSQPDAKIFYVAFTQDGQQEQTRPVTFFYNGGPGSSAVFVLLGSFAPRRIRTSMPSFTPPAPYRMEDNPDSLLDKSDLVFINPVGTGYSAAIAPRKNRDFWGVDQDANSIKQFIKRYLTKHNRWNSPKYLFGESYGTARSCVLAYKLHEDGVDLNGITLQSSILDYRQAGNPVGALPTAAADAWYHKRLGVAPTPTDLGAFVEEVAQFARTDYLGALRKFPQADAAVVKKLSDYTGIDTTTLLSWSLDIAGYDARGNALFLTTLLKAQGLALGAYDGRVTGIESGIAGRIDPNSGGNDPTMTAVSGVYTAMWNTYLNEQLKYTSNSSFTDLNDQAFKYWDFGHIDPTGEQQGVDAKGNVILYTAGDLAATMALNVDLKVLSANGLYDFVTPFYQTVLDLQQMPLEDPKVRQNLSARFYPSGHMVYLDGGSRTTLKHDLAQMYESTVRDTAAVMRIRALQEKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K08</accession>
    <name>Q63K08_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">kgtP</name>
        <name evidence="7" type="ordered locus">BPSS1558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188597.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1558"/>
    <dbReference type="EnsemblBacteria" id="CAH39031">
        <property type="protein sequence ID" value="CAH39031"/>
        <property type="gene ID" value="BPSS1558"/>
    </dbReference>
    <dbReference type="GeneID" id="56597904"/>
    <dbReference type="KEGG" id="bps:BPSS1558"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4921"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACMKETA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="439" mass="47337" checksum="A16F9E8FFA78C938" modified="2004-10-25" version="1">MSQVRSLATAPHCPPAGTLARLRSIFSGSVGNLIEYYDWYVYSAFSLYFAKVFFPSGSQTVQLLNTAAIFAVGFVMRPIGGWLVGLYADRKGRKAALLVSVLAMCAGSLIIGLTPGYGSIGIAAPVLLVLARLLQGLSLGGEYASSATYLSEMADKTNRGFYSSFLFATLSLGQLLAMAVLVALQQFFLSAAQLESWGWRIPFLIGSLAAGVAIFLRRNMEETESFEQHRQSRRSRTSVAELFRHKRACLIVAGLTLGGTVAFYAYTTYMQKFLVNSAGMSKADASMVSVASLIAFVLMQPVFGSLSDRVGRRPLLIAFGVLGTLCTVPIFSALTTVRTMGGALALISAALLIVSLYSSVSAVAKAELFPVEIRALGVGLPYAITVSLFGGTAEYIALWTKSIGHETWFFWYVSGCVLVSLLCYLWMPDPKTVSCIDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA6</accession>
    <name>Q63KA6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528759.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111466.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1460"/>
    <dbReference type="EnsemblBacteria" id="CAH38931">
        <property type="protein sequence ID" value="CAH38931"/>
        <property type="gene ID" value="BPSS1460"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1460"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4793"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QLISVFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="237"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="453" mass="47385" checksum="92573B4BBEB391C0" modified="2004-10-25" version="1">MLRSLQGRLSAALVAGLVALSAAGGAAAFYVLRAEVEQMSDSALQETAQRLLPLAVMDIVGRDSDGDDGDGGGGRIAAVRPHDELLTYIVRDETGKLLLRSHDANARLFPKNLKAGFARTATHRVYAETVLQGTVTLLIAEPLATRRRAEVQAAFAVVRPLALFLPVGLLGIWLIVRSGLTPIRRFCGAIAARGRNDLTPLDKGGLPAEIAPVADAVTELMARLDRALAAERSFTANSAHELRTPIAAALAQTQRLIAEAPAEPLRERARRVEGALHTLSRVSEQLMQLAKAEDGRVLADTPQDLRPVLALVVDDFRRGARDRAIALELPDTAVTSRIDPDAFAIVVRNLVENALKHGAAAEPVRVALSAAGALSVTNRGPVLAAAELERLTKPFERGATAAKGSGLGLAIVDAIAKGAGASFTLRSPAPGVTDGVQARVDGLACGGGPAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA9</accession>
    <name>Q63KA9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184801.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111463.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1457"/>
    <dbReference type="EnsemblBacteria" id="CAH38928">
        <property type="protein sequence ID" value="CAH38928"/>
        <property type="gene ID" value="BPSS1457"/>
    </dbReference>
    <dbReference type="GeneID" id="56597708"/>
    <dbReference type="KEGG" id="bps:BPSS1457"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4789"/>
    <dbReference type="eggNOG" id="ENOG502Z7RS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GCFDWHS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021365">
        <property type="entry name" value="DUF2891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11199">
        <property type="entry name" value="DUF2891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="37127" checksum="CB8030A76C143B57" modified="2004-10-25" version="1">MTARQLTPALASRFANLALSHLTREYPNKLTHSLAGPQDVLGPRALHPIFYGSYDWHSCVHGYWLVTRLLDRFPDLPEGPRIVATVDAHFTAGNVAGEAAYLNLPHNRGFERPYGWGWLLALSAQLASMKSDAGRRWSATLAPLTDLFVERFAEFLPKATYPLRVGTHFNTAFALSLALDFARQTGHAALEALIVDTARRWHLRDANCQAWEPSGDEFLSPALMEAELMRRVLPAAEFLAWFDAFLPSLAAREPATLFTPATVTDRTDGKIAHLDGLNLSRAWCQRALARALPDGDPRRAALADAADAHLASALEHVAGDYMGEHWLASFALLALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KB1</accession>
    <name>Q63KB1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525382.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111461.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1455"/>
    <dbReference type="EnsemblBacteria" id="CAH38926">
        <property type="protein sequence ID" value="CAH38926"/>
        <property type="gene ID" value="BPSS1455"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1455"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4787"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYDMDLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="102"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="263" mass="31122" checksum="1391B51DE504E347" modified="2004-10-25" version="1">MNDAAQADFLPIDRRDALSYEAFVEQYALPGKPVVLTGLMRDWEAARVWNFEYFRRRHGHVTIVARRSDDYDRTITLPLADYLDRLDDPDAHFYLKDWVFENDIPELRAQYRVPRHFANWVTRVPGKWQPKWRWLYIGPASSASHLHVDFLLTSAWNALFVGAKRWLAYSPDQARRMYRGAVDAFHPDLERFPGFAHARAHMHVQRPGEIMYMPATWWHAVRNEEPSLALSENFINAVNARYFLKPRVIARFLRYADHPLWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KF5</accession>
    <name>Q63KF5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative type III secretion-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sctS</name>
        <name evidence="8" type="ordered locus">BPSS1405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551832.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111417.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1405"/>
    <dbReference type="EnsemblBacteria" id="CAH38880">
        <property type="protein sequence ID" value="CAH38880"/>
        <property type="gene ID" value="BPSS1405"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1405"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4729"/>
    <dbReference type="eggNOG" id="COG4794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIWILPP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006306">
        <property type="entry name" value="T3SS_HrpO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01403">
        <property type="entry name" value="fliQ_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="87" mass="9207" checksum="17006D05ADFEAAEC" modified="2004-10-25" version="1">MEIDSLIRFCTQAMLLCLTVSLPPVIVAALVGLGVSFVQAITSLQDQTLPQVLKLIAVTITIMVAAPTGCAAILHFANQMMQLAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM6</accession>
    <name>Q63KM6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184524.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111345.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1335"/>
    <dbReference type="EnsemblBacteria" id="CAH38806">
        <property type="protein sequence ID" value="CAH38806"/>
        <property type="gene ID" value="BPSS1335"/>
    </dbReference>
    <dbReference type="GeneID" id="56597538"/>
    <dbReference type="KEGG" id="bps:BPSS1335"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4634"/>
    <dbReference type="eggNOG" id="ENOG5032ZD6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMRCGNG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021430">
        <property type="entry name" value="DUF3079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11278">
        <property type="entry name" value="DUF3079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="70" mass="7983" checksum="0C39C099057A8046" modified="2004-10-25" version="1">MAKKFPLHPKHPERNCWGCDRYCSVDALSCGNGSDRTQHPIELLGDDWYEWEQENEAAQQPIQSVPAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ6</accession>
    <name>Q63KQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184428.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111315.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1306"/>
    <dbReference type="EnsemblBacteria" id="CAH38776">
        <property type="protein sequence ID" value="CAH38776"/>
        <property type="gene ID" value="BPSS1306"/>
    </dbReference>
    <dbReference type="GeneID" id="56597508"/>
    <dbReference type="KEGG" id="bps:BPSS1306"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4596"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KESPWVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267315" evidence="1">
        <location>
            <begin position="34"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="78"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="520" mass="57109" checksum="F7F0B4B927158210" modified="2004-10-25" version="1">MTQPHSFLPFSPRALLVACAGAIAMSSAPLALAERAAVMAVDSTFTTLDPYDSNDTLSQAVSKSFYQGLFGFDKDMKLVNVLATGYEASPDAKVYTIRLRQGVKFQDGTDFNAAAVKANFDRVTDPANKLKRYNLFRRIAKTEVVDPYTAKITLTEPFSAFINVLAHPSAVMISPAALKKYGREIGLHPVGTGPFELVEWKQTDDLKVKKFAGYWKAGYPKIDAIDWKPVVDNNTRAALMKTGEADFAFRIPFEQTAELKASPKVDVIERASIIQRYVSLNVMQKPFDNPKVRQALNYAVNKEALAKVAFAGNATPATGIVPQGVDYAVKLGPWPYDPAKARALLKEAGYPSGFETTLWSAYNNSTSQKAIQFVQQQLAQVGVKAQVQALEAGERVAKVESAQDPAKAPVRMYYIGWSASTGESDWAISPLLASSSIPPKLVNTAYYRNDAVDADLAKALETTDRAKKAELYADAQRRIWADAPWIALVQEKIVYARSKRLQGAYVMPDGSFNFDEIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KX7</accession>
    <name>Q63KX7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sugar transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205568.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111244.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1236"/>
    <dbReference type="EnsemblBacteria" id="CAH38703">
        <property type="protein sequence ID" value="CAH38703"/>
        <property type="gene ID" value="BPSS1236"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1236"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4485"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYFKFDM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="397" mass="42247" checksum="82BE5F6E552A65C1" modified="2004-10-25" version="1">MARIVCTGLTKRYDGGAPVLHPLDLEIGDGEFIVLLGPSGCGKSTMLRMIAGLETITGGTLAIGGAVVNDLAARERNVAMVFQNYALYPHMSVYENIAFGLRRLKVPAAEIDRRVREVARVLGLDALLDRKPRAMSGGQQQRAAIARAMIKTPDVFLFDEPLSNLDAKLRAQLRGDIKRLHQRLKTTTLYVTHDQLEAMTLADRIVLMRGGRIEQLGTPAELYGCPHTVFAAGFVGTPAMNFADGVIEHTAGRVALAAGGARWTLAARRFAGLPDGLRVKLAIRPNYLRIAPGAHAPAATLALEGRVELVELLGAEALVTFGCNGAPFAALVPASAAPALGAVVTFTFDERDLHLFDAATGRNVMLPGAGAPADAERPGAAMRPSPGAPHRFTMSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L16</accession>
    <name>Q63L16_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111205.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1195"/>
    <dbReference type="EnsemblBacteria" id="CAH38662">
        <property type="protein sequence ID" value="CAH38662"/>
        <property type="gene ID" value="BPSS1195"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1195"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5363"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="436" mass="45151" checksum="922C6CA939790D83" modified="2004-10-25" version="1">MSATSETALHGFRLSPVQQRVWTLTDAGRLPAAQRVVARFAWTAAPPSRAALEAALNALIGRHEILRARFARLPEMRLPLQTAPDGARLRLDGACAPDVPGTPDTPDMPDAGAPALHAAMDATGLVLSLPALCADGPTMLHLGAALAARLAGDDADGQAPLQFFDLAQWQHDLLAEEGAWRWPDGALQSAHGPWPALPALRSARAAAYRPARHACALPADTGARVGALCARLGVTPADLLCAVWAVLLHRLSGGDTLPVAIVADGRPFDELATALGPLAAPVPLSLSAALGAPDGTFAGLAKAAADARATAADLRHHLVPPDEARFAPFQIEVLDAGRADDALLRVVDVATAGEPALLKLSVLVGPGGALRADIDHDAGAVRDGGAIARLAEQFATLLDAVLANPDATFDEPDLLGAAERRLVTEDFQGPQVKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L80</accession>
    <name>Q63L80_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205544.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111141.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1128"/>
    <dbReference type="EnsemblBacteria" id="CAH38596">
        <property type="protein sequence ID" value="CAH38596"/>
        <property type="gene ID" value="BPSS1128"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1128"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4346"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MWGIATL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="467" mass="47242" checksum="1984691274FE97A0" modified="2004-10-25" version="1">MSSITAPSWGELLSGRNGLRSIALAGGVALHAINIYIATTILPSVVRDIGGLEYYAWNTTLFMAASIVGAPLSANVLSRFGPRAAYLVALVVFCAGTLACAGAKDMPWMLVGRAAQGFGGGILFALSYALIRIVFDERLWSRAMAMVSGMWGVATLCGPAIGGVFAQSGTWRLAFVALVPVAAVLALIVIVQLPAREASGARAARPAIGKILLLAVSVLVVSVASLSKAIVANVAGVAAGLAVALLIARLERGAARRLLPTGAYDVRAPLGAIYACMSLLVIGMTTEIFVPYFLQIIHGYPPLLAGYLTALMAAGWTAGSLFSSGRSGAAAQALVRGGPLVVVIALVALALVVPPQHLLAGGAGLAALCAALAAVGVGIGMGWPHLLTQVLTNAPAGQEDLASTSITTVQLYATAIGSALAGLVANLAGFSAPGGLAGAQHAAAWLFAVFAAAPVLAAIVARRVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L97</accession>
    <name>Q63L97_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528326.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111124.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38579">
        <property type="protein sequence ID" value="CAH38579"/>
        <property type="gene ID" value="BPSS1111"/>
    </dbReference>
    <dbReference type="GeneID" id="56530475"/>
    <dbReference type="KEGG" id="bps:BPSS1111"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4323"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PWPEPHM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="142"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="28172" checksum="F567F996563215D1" modified="2004-10-25" version="1">MTPSVIALVLFAAILHATWNALLKSGADRLWSLTVMSFATTAAAAVCAALLPLPARASWPYLAASAALQVGYSVFLALAYQRAALGQVYPVVRGAVPLLVTLGGYAWAGQRLGGAPLAGIALVSGGIASLALGRTRIHSRALAAALATALFIGGYVTIDGLGARVAGHPLAYAAWIFIVYGAAMPAVFLLLGRRPRAGLPRGDTLKSAAGGLISLIGYAAVVDALSRGPVGPIAALRETSIVFSALIGWLWLGEKPSGPRFAACAAVALGAACLAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LE8</accession>
    <name>Q63LE8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phage portal family. PBSX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205524.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111073.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1062"/>
    <dbReference type="EnsemblBacteria" id="CAH38528">
        <property type="protein sequence ID" value="CAH38528"/>
        <property type="gene ID" value="BPSS1062"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1062"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4259"/>
    <dbReference type="eggNOG" id="COG4695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FFYAPNG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030935">
        <property type="entry name" value="PBSX_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006430">
        <property type="entry name" value="Phage_portal_PBSX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018494">
        <property type="entry name" value="PBSX_VPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01540">
        <property type="entry name" value="portal_PBSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="351" mass="39489" checksum="EADDB3CC39BA2BED" modified="2004-10-25" version="1">MSKRRSRAPRTFAAAPNPSAGSAAPARAEVFTFDEPTPVMNRAEILDYVECWSNGEWFEPPVSFAGLAKSFRASTHHSSALFFKANVLASTFRPHRWLSRHAFERWALDFLTFGNGYLERRRNMVGGTLRLEPALAKYVRRKADFSGFVYVNGWQERHEFAPDSVFQLVRPDINQEVYGLPEYLSSLHSAWLNESSTLFRRKYYENGSHAGFILYMTDAAQKQDDVDNMRDALKNAKGPGNFRNVFMYAPGGKKDGIQLIPVSEVAAKDEFFNIKNVTRDDLLAAHRVPPQLLGIVPSNSGGFGTPDTAARVFGRNEIRPLQARFAELNDWLGDEVVTFDDYEIPPAPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LT8</accession>
    <name>Q63LT8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202681.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110933.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0924"/>
    <dbReference type="DNASU" id="3096634"/>
    <dbReference type="EnsemblBacteria" id="CAH38387">
        <property type="protein sequence ID" value="CAH38387"/>
        <property type="gene ID" value="BPSS0924"/>
    </dbReference>
    <dbReference type="GeneID" id="56597284"/>
    <dbReference type="KEGG" id="bps:BPSS0924"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5027"/>
    <dbReference type="eggNOG" id="COG3687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRFENML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="35323" checksum="FA794435FC57AD48" modified="2004-10-25" version="1">MTTPHMMPVRRDIRFALPADRAHDWHVQGAPVTHFMNALSLLFPAGERFFMDSVRNYRDEIHDPELKKQVAGFIGQEAMHTREHIEYNDLLQSAGLPAHKLDKRLWALLGWGKKVLPNSVQLAITIALEHYTAILANQLLSGYTHRIDGSVEGYKQMWLWHAMEETEHKAVSYDVWNTVMKPGVKTYLLRTGTMLATTLIFWAVVFDFHVRLMFAHRMRHGKLKGMWRLVKYLYSPKNGVFPSIALEWLDYFRPGFHPWDHDNRVYLQGLDTLLANIDAANERYADQVAPRRVPLHSLPEHQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LV2</accession>
    <name>Q63LV2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184696.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110919.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0910"/>
    <dbReference type="EnsemblBacteria" id="CAH38372">
        <property type="protein sequence ID" value="CAH38372"/>
        <property type="gene ID" value="BPSS0910"/>
    </dbReference>
    <dbReference type="GeneID" id="56597270"/>
    <dbReference type="KEGG" id="bps:BPSS0910"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7205"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HATFLYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="15782" checksum="DF254D3DE7D86204" modified="2004-10-25" version="1">MLKLLVPVGQSQRSLQAVRHAAFLYHERCASEVVLVNVQPPLESTRLEAFHSLAKLRQIEHDFSEGELAQAIGILKDADVKYSVAMKVGPIADAIAACATENGCDEIVVVAPRRDPVHALTHCFHRSILDRLVRIASVPVTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M09</accession>
    <name>Q63M09_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553318.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110862.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0850"/>
    <dbReference type="EnsemblBacteria" id="CAH38313">
        <property type="protein sequence ID" value="CAH38313"/>
        <property type="gene ID" value="BPSS0850"/>
    </dbReference>
    <dbReference type="GeneID" id="56530695"/>
    <dbReference type="KEGG" id="bps:BPSS0850"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7136"/>
    <dbReference type="eggNOG" id="ENOG5031YUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IQDTKRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021439">
        <property type="entry name" value="DUF3088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11287">
        <property type="entry name" value="DUF3088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="114" mass="12541" checksum="29DFE74A31BB33BC" modified="2004-10-25" version="1">MSRDLLLLLEPGFTDPRHPGERFVCPGSVPIEGLLASDPSKQPRLDIRRLPFARPREAAIAALDADHQGLPVLILGDDAPPPDDALALGQTRFVTDSRRILELLAERHGFPKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M17</accession>
    <name>Q63M17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110854.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0843"/>
    <dbReference type="EnsemblBacteria" id="CAH38305">
        <property type="protein sequence ID" value="CAH38305"/>
        <property type="gene ID" value="BPSS0843"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0843"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4936"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTAFIRD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="253" mass="26304" checksum="9194F76E395B326A" modified="2004-10-25" version="1">MSSRSIPLAWIAGVGASAGLGAALGRRFARGGYAVVLTGRTHERVAAVADEIRAQGGVAHVASGDIASEADVERLAIEVRTLGALRAAVFNAGNAVRAPTLELSVAQFEHAWRTNVIGGFLFAKAALAQLLDADGGAPGDDTPRSLLFTGATASLRGRPPFAAFASAKAGLRSLAQTLAREFGPRGVHVAHAVIDGGIDGERLRGAAPERVAQAGADGLLSPDAIADSYWQLHVQHRSAWTQELDLRPYNEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M92</accession>
    <name>Q63M92_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532825.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110779.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0768"/>
    <dbReference type="EnsemblBacteria" id="CAH38228">
        <property type="protein sequence ID" value="CAH38228"/>
        <property type="gene ID" value="BPSS0768"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0768"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7011"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="80" mass="8556" checksum="21A07DE7B8019A1B" modified="2004-10-25" version="1">MPRSRAPSNARPHGHTLIDQASVVRFIEDNWLGGQRIGGGSFDATAGDMRDLFDFSGAVNKTPLYLDPTLGTKLATAPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ6</accession>
    <name>Q63MQ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530090.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110615.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0594"/>
    <dbReference type="EnsemblBacteria" id="CAH38051">
        <property type="protein sequence ID" value="CAH38051"/>
        <property type="gene ID" value="BPSS0594"/>
    </dbReference>
    <dbReference type="GeneID" id="56530954"/>
    <dbReference type="KEGG" id="bps:BPSS0594"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6770"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKFWGVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014090">
        <property type="entry name" value="Siderophore_transpt_RhtX/FptX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="PTHR12778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02718">
        <property type="entry name" value="sider_RhtX_FptX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="423" mass="43974" checksum="87C6220E032038DF" modified="2004-10-25" version="1">MRDLLEHRRLVITITLLYLSQGIPIGIAMDAMPTLLRHDGAPLHALAFLPLVGLPWVVKFLWAPVVDNRWSARIGRRRSWMLPMQCIVVLCLASLAQIGMTVATAGWAVGLLAVASLASATQDIANDGMAAEHFRGGALAKINAIQIAGVMIGFFGGGAGALTLIGLFGQRAAFLALAAVPLASLACVLWLMPREAGRPGAPRAHDASLARFAKRPLSLSLLALALLSAMTAVSGFGLSKLFLNDAGWTLEAIGRLGMAGGIVTVVLGCGGGAWLVRRLGLWRAFSAGVSCAGAGALLWFAQANGWLASAPHWVWLCTVLGSLSTGITSVSIMTAGMRFAGDGDQAGTDVTAVQSTRDLGELIASSMMLTLTSKVGYSGGFLAGAVLAALAALIAARLRRREAGRPARLHVRAVSDAPMTGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MU6</accession>
    <name>Q63MU6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative electron transfer flavoprotein alpha-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523138.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110573.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0552"/>
    <dbReference type="EnsemblBacteria" id="CAH38009">
        <property type="protein sequence ID" value="CAH38009"/>
        <property type="gene ID" value="BPSS0552"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0552"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6720"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWIARNR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="7">
        <location>
            <begin position="62"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ETF_alpha" evidence="6">
        <location>
            <begin position="251"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH38009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="390" mass="40245" checksum="07BD650394222A46" modified="2004-10-25" version="1">MTTLKRIDPRRPFVVTAAGLKRITLGETGGAPGDAASWRPHAHGAAAARPVRVVRDARRVFLVAAHSERGALDDHARQTLAAAALLADAQTEVALVVFGELNDDAGAFGADTLVVLRDFDRRAFAPERELDALRACAAALSPQHVFIPDNATGDGDLGRRYAAAANASVATQVVEIAADHVGVYVDAKRGFATRTLPDVVLLAPNAVDPTLPFVGAARTLAAPDARAAGDGGDARYRDFGLEEIDAAQVALEEADFIVSAGNGVTDIAAFETLAATFGAAIGASRVAVDNGHFARDKQVGATGKTVDASIYIAFGISGAVQHLQGIKDCRHVIAVNLDGSAPIAKRANLTIVGDAQATIAALIEAVNAARAAQPRAGAVSNEREYMGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N33</accession>
    <name>Q63N33_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">potI</name>
        <name evidence="7" type="ordered locus">BPSS0464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525492.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110486.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0464"/>
    <dbReference type="EnsemblBacteria" id="CAH37920">
        <property type="protein sequence ID" value="CAH37920"/>
        <property type="gene ID" value="BPSS0464"/>
    </dbReference>
    <dbReference type="GeneID" id="56531085"/>
    <dbReference type="KEGG" id="bps:BPSS0464"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6611"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="309" mass="33545" checksum="379E21B5B31CDE30" modified="2004-10-25" version="1">MIKPNKPLCAGVLTLGFLFLYIPIVSLVVYSFNESKLVTVWSGFSLKWYAALWRDDELLTSAWLSLKIGLLTAFASVFIGTWAGFVLARFGRFRGFTLYTGMINAPLVIPEVIQGISLLLLFVALEQMAGWPKGRGMVTIWIGHVMLCVSYVAIIVQSRVKELNKALEEAALDLGATPLKVFFVITLPLISQALLSGWLLSFTLSIDDLVLSAFLSGPGSTTLPLVVFSRVRLGLNPEMNALATLFITAVTIGVIAVNQMMLSRERRRERDMRQAFAPPAPCDSPESGPAGGAPRAARAAATRKPLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N46</accession>
    <name>Q63N46_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Family S11 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS0451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205413.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110473.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37907">
        <property type="protein sequence ID" value="CAH37907"/>
        <property type="gene ID" value="BPSS0451"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0451"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4450"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LVVVQMY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266611" evidence="9">
        <location>
            <begin position="32"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="108"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="362" mass="39564" checksum="995F68844B6129CB" modified="2004-10-25" version="1">MCEFVLRTSKRTVLPIVLASALAVPSFGAQARSSVSKRHAAAAASIRTASFHPQSGHTPLARHALASRHLKAGRYRLAGGMRRVAFSPRAPLGGRAFEPRDASQSFGLRSNIVYMVDQHTGETLFDRNSRSVVPIASVTKLMTAMVVLDSNAPLDERIEVTDDDRDQDKFTGSRLAIGSALSRDDMLHIALMASENRAAAALSRYYPGGREAFVDAMNRKARSLGMVDTYFENPTGLSKHNVSSARDLAKMVEAAYQYPLIRQYSTDLKYDVDTGLRTLYYHSTNVLLRDNAWNIGVQKTGYIKESGICLVMQTTIDGRDVVMVLLDSAGRHSDFFDAARLRTMLTSGAAHVTEANSATSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N57</accession>
    <name>Q63N57_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009932930.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110462.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0439"/>
    <dbReference type="EnsemblBacteria" id="CAH37895">
        <property type="protein sequence ID" value="CAH37895"/>
        <property type="gene ID" value="BPSS0439"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0439"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6580"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DAHDYAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="228" mass="25420" checksum="1C5EA5B873FE20C4" modified="2004-10-25" version="1">MSDPKLEVLTPHNSQLIFIDQQPQMAFGVQSIDRQTLKNNVVGLAKAAKIFNVPTTITTVESESFSGFTYPELLDVYPDHKLLERSSMNSWDDQKVRDALKANGRKKVVVSGLWTEVCNTTFALCAMAEGGYEIYMVADASGGTSKDAHDYAMQRMIQAGVVPVTWQQVLLEWQRDWAHRDTYDAVMTLVKEHSGAYGMGVDYAYTMVHKAAQRTANAHDMLAPVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB3</accession>
    <name>Q63NB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552320.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110406.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0384"/>
    <dbReference type="EnsemblBacteria" id="CAH37834">
        <property type="protein sequence ID" value="CAH37834"/>
        <property type="gene ID" value="BPSS0384"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0384"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6511"/>
    <dbReference type="OMA" id="AWAHHAT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="40069" checksum="ABF74CE93FE300CA" modified="2004-10-25" version="1">MQYGLYRSFGAVVEDIEYETNSLETIALRNQRVPINPLSDDFCEDLLAPLDRANIARLRKEWRDMAGSLIEIIDAARDRHWKRDGPYRLRYCWRRAEIVEEEAYPAWAHHATQDLLRNAYSIFKRGGEAEADDGHLLTLARHYIRPHVSLTDAHLLSGLAIREAVRAVEHLTTLVDHVEQDEHVAVWLKEWLRQDVQDNDYARKAYGAELNARIDRAALDIFHPDLETVTDYRIHAEKLLLLADVCATGRLSSTESSRLFAQLEVREQHIEELDSTVAAMRAKRENFQIKGTLARTKLTTADKDEVKRQYDDLIAAHPDKQVKDIELTLADQWGVARSTIQRATGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NG3</accession>
    <name>Q63NG3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110356.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0336"/>
    <dbReference type="EnsemblBacteria" id="CAH37784">
        <property type="protein sequence ID" value="CAH37784"/>
        <property type="gene ID" value="BPSS0336"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0336"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4328"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWCLTHK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="238" mass="26839" checksum="ED6969926B4A2B29" modified="2004-10-25" version="1">MLAHFAQLEPVFDALPDVAFFVKDVRARYALVNRTLAQRCGYKDKRDLYGKAADEVFPRRFGRSYVEQDLTIIAGGRQLTDQLELHLYSGRQPGWCLTCKEPLRNAQGRIVGIAGLSRDLRAHESSHPAYSRIADVVRYIHAHYVQPLNLKHLAGMAGMSVAQLERYFHKVFHLTPRQMLLKARLDAATALLVTHDKVTDVAALCGYTDHSAFTRQFKATVGVTPTEYRLMLQEGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NG5</accession>
    <name>Q63NG5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523445.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110354.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0334"/>
    <dbReference type="EnsemblBacteria" id="CAH37782">
        <property type="protein sequence ID" value="CAH37782"/>
        <property type="gene ID" value="BPSS0334"/>
    </dbReference>
    <dbReference type="GeneID" id="56531205"/>
    <dbReference type="KEGG" id="bps:BPSS0334"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6453"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRAPFCG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="77" mass="8336" checksum="084D66A9280EF1D7" modified="2004-10-25" version="1">MIIYLDRRALEVADGTTVAAALALAGDDTARTSCTGAARAPFCGMGMCHECRVTIDGRRRLACQTLCREGMQVERTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NG7</accession>
    <name>4HYPE_BURPS</name>
    <protein>
        <recommendedName>
            <fullName>4-hydroxyproline epimerase</fullName>
            <ecNumber>5.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Hydroxyproline-2-epimerase</fullName>
            <shortName>BpHyPRE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">BPSS0332</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="PLoS ONE" volume="2" first="E885" last="E885">
            <title>Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens.</title>
            <authorList>
                <person name="Goytia M."/>
                <person name="Chamond N."/>
                <person name="Cosson A."/>
                <person name="Coatnoan N."/>
                <person name="Hermant D."/>
                <person name="Berneman A."/>
                <person name="Minoprio P."/>
            </authorList>
            <dbReference type="PubMed" id="17849014"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0000885"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline</text>
            <dbReference type="Rhea" id="RHEA:21152"/>
            <dbReference type="ChEBI" id="CHEBI:57690"/>
            <dbReference type="ChEBI" id="CHEBI:58375"/>
            <dbReference type="EC" id="5.1.1.8"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Inhibited by iodoacetate, iodoacetamide and by high amounts (10 mM) of pyrrole-2-carboxylic acid (PYC). Not inhibited by PYC at 1 mM.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">14.4 mM for 4-hydroxy-L-proline</KM>
            <KM evidence="3">17.1 mM for 4-hydroxy-D-proline</KM>
            <Vmax evidence="3">2.1 uM/sec/mg enzyme with L-proline as substrate (at 37 degrees Celsius)</Vmax>
            <Vmax evidence="3">2.4 uM/sec/mg enzyme with D-proline as substrate (at 37 degrees Celsius)</Vmax>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text>This enzyme does not require pyridoxal phosphate (PLP) as a cofactor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.8"/>
    <dbReference type="EMBL" id="EF495345">
        <property type="protein sequence ID" value="ABS82397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523447.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110352.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63NG7"/>
    <dbReference type="SMR" id="Q63NG7"/>
    <dbReference type="STRING" id="272560.BPSS0332"/>
    <dbReference type="EnsemblBacteria" id="CAH37780">
        <property type="protein sequence ID" value="CAH37780"/>
        <property type="gene ID" value="BPSS0332"/>
    </dbReference>
    <dbReference type="GeneID" id="56531207"/>
    <dbReference type="KEGG" id="bps:BPSS0332"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6451"/>
    <dbReference type="eggNOG" id="COG3938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHVLWTG"/>
    <dbReference type="BRENDA" id="5.1.1.8">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047580">
        <property type="term" value="F:4-hydroxyproline epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000354034" description="4-hydroxyproline epimerase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4KGU2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17849014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="310" mass="32118" checksum="4315A2A48443A002" modified="2004-10-25" version="1">MKHIHIIDSHTGGEPTRVVVSGFPALGGGTMAERLAVLAREHDRYRAACILEPRGSDVLVGALLCEPVSAGAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIGPGVHRIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVDVPGHGAVTGDVAWGGNWFFLVSDHGQRVAGENVAALAAYASAVRAALERAGVTGRDGAPIDHIELFADDPEYDSRSFVLCPGHAYDRSPCGTGTSAKLACLAADGKLAAGVTWRQASVIGSVFSASYAAAEGGVVPTIRGSAHLSAEATLVIEDDDPFGWGIAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NR0</accession>
    <name>HMUV_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemin import ATP-binding protein HmuV</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hmuV</name>
        <name type="ordered locus">BPSS0240</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188492.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110259.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63NR0"/>
    <dbReference type="SMR" id="Q63NR0"/>
    <dbReference type="STRING" id="272560.BPSS0240"/>
    <dbReference type="EnsemblBacteria" id="CAH37686">
        <property type="protein sequence ID" value="CAH37686"/>
        <property type="gene ID" value="BPSS0240"/>
    </dbReference>
    <dbReference type="GeneID" id="56596992"/>
    <dbReference type="KEGG" id="bps:BPSS0240"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6324"/>
    <dbReference type="eggNOG" id="COG4559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KALCQEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51261">
        <property type="entry name" value="HMUV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000269584" description="Hemin import ATP-binding protein HmuV">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01718"/>
        </source>
    </evidence>
    <sequence length="272" mass="28401" checksum="088A93846E628CB0" modified="2004-10-25" version="1">MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPRLARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTHADGEIASQALALAGATALDARDVTTLSGGELARVQFARVLAQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPADVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NT6</accession>
    <name>Q63NT6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523513.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110233.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0213"/>
    <dbReference type="EnsemblBacteria" id="CAH37658">
        <property type="protein sequence ID" value="CAH37658"/>
        <property type="gene ID" value="BPSS0213"/>
    </dbReference>
    <dbReference type="GeneID" id="56531332"/>
    <dbReference type="KEGG" id="bps:BPSS0213"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6284"/>
    <dbReference type="eggNOG" id="ENOG5033UZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEHAVMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014992">
        <property type="entry name" value="DUF1842"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014994">
        <property type="entry name" value="DUF1843"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08896">
        <property type="entry name" value="DUF1842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08898">
        <property type="entry name" value="DUF1843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1842" evidence="2">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1843" evidence="3">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="196" mass="21668" checksum="B3452B266B866107" modified="2004-10-25" version="1">MATTGLFPVQLRVATPNLGAPVLWLNLLVNTVEKTASGFARITQTVYPPMHFRARVVGPFHQMRIDPHAPQSVTLTLSGSPTGPVAPQVVILELNALLNEGWQSGTANYRYFYESRWHSIEHAIVSKDNSRIPLDPPSEHVMPMYGVGLQEARASGDLSRMKALAQQAEQQLADHDVIAAELQKLEAEIARLEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P43</accession>
    <name>Q63P43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551174.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110126.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0103"/>
    <dbReference type="EnsemblBacteria" id="CAH37549">
        <property type="protein sequence ID" value="CAH37549"/>
        <property type="gene ID" value="BPSS0103"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0103"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6132"/>
    <dbReference type="eggNOG" id="COG3523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAEIFRF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009612">
        <property type="entry name" value="IcmF-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010623">
        <property type="entry name" value="IcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017731">
        <property type="entry name" value="TssM1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06761">
        <property type="entry name" value="IcmF-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06744">
        <property type="entry name" value="IcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03348">
        <property type="entry name" value="VI_IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="4">
        <location>
            <begin position="265"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related" evidence="3">
        <location>
            <begin position="590"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF_C" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1302" mass="142957" checksum="F366509A7F854E91" modified="2004-10-25" version="1">MSYLKRFLRFVFSWQMLACIAVLLVCAAVWFVGPLLAFDELRPLAGVVVRVAVIVLLVALLAFWLLRWPLSPIGVAALCLLIWHAGPLFAFGDHRPFGPAWVRVLIVAAMLFCYAVYGLYRLWRAVRTNDALLKRILEPSAGKPDAAAQANIRAVSVAVSKAIGQLKRLRGGAFGWRRLLESGRYLYELPWYMVVGAPGAGKSAAIARSGLKFPLADQMEASSERARGGTANCEWWFANEAVLIDTAGRYVRHEVPGDEEATVANGAEWKGFLGLLRKHRPRAPVNGVVLSVSVEELVGRTPAERTAHAATLRARLGELHQELGIHFPVYVIVTKLDLLPGFPEYFQSLTAEGRTQIWGFTLPYDAENRRSAVGALREHCADELKRLEMRIDAGLNNRLLEEYENDRRKRLYALPQEFRSLSAALSDMLALVFLDSRYDDAQLQNTLRGVYFTSAEQTDQVLAADRETILQRLKRQLGRMLGGDAGAQTRDSGAVSGSRGYFLRDVFQHVIVPEAHLVRPNVRWEVRFRLMRWAGHLLAVALLVWLASALTVSFDNNRGYLDAISEKTAALAARVNAYNKAPKPAQIGGVLDGARDLPQHGNLDLDAPGASFRYGLYVAPGIVDASDATYRSLLRRSLLPQIVRRVEDALSAQIDAKHADEVYRTLTVYLMLDDAARHDAKAVKDWVMRDWERSDSAAEMGGRNLMARHLDALFVDARPFEPSGHRNAALVQRARLFLNANPAPRRLYERAMAAIEKEAPENFTLARAVGLQGAGIFRLADGSRFQRGMPGLYTYDGYHQVFSARLPEFLARAQSDDAWVMGNAGPAARWGDAIRNTQAVAGRSSLADDIRRQYLTDYGNYWQQYLADIRPASSGEDGAGGTLAFDLATLRALAAPDSPLVRLARAVVRETSLSVVDAREDASLTDAALSSLGRRSGAAKEVADGAQKLAARRPEQRLEKELVDNRFAALREVVTGQADTGSGPAMTDVPVAAGGRALQLDAILTLINEQYTRLVVADNALSSQSMPPALDIGTTLQMEAEKLPAPLRTVLGGIATQAADKVGREVGSLLAMQVDSSVGNACRAAVDGKYPFARSAQEVDIEDFNRLFAAGGLFDAFFQKALAPHVDTHSKPWRYKALNPGMPPIRGPSLEPFERAAAIRDVFFREPGAKRMAWRMDAKVASIDPEITELIVDVDGQSQRYVHGPVLPFSVNWPGPRGGAIAEITAKPRIRPDTSTIATTGPWALFRLIERGRLTGTTSASRLMLDFDFDGRHAALELRTNGQMNPLTSGLLTHFRCPGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P71</accession>
    <name>Q63P71_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533801.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110098.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0076"/>
    <dbReference type="EnsemblBacteria" id="CAH37520">
        <property type="protein sequence ID" value="CAH37520"/>
        <property type="gene ID" value="BPSS0076"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0076"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INQPLMV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="30582" checksum="547C563754AA8617" modified="2004-10-25" version="1">MMNSHELRRFPLTAGIATTVLLFLYLPLLVIGWMSFNDGPSALMWKGWSTRGYIEAWADPTLIRAIQNSLALALGSMVLSTGLATSAAVAAWSRTERRAVDLRTFVIGLPLAIPEVVLAIATMMLFSMLGLDVGFVAVLFAHVVFCVPLAYLPINARLKTIDRTLLEAAADLSAPPWAAFRQITLPLALPGIVAGALLSFVASMNDYVTSYFLAGAGMSTLPMYIFSSLKIGISPKISAVSIAVVALSSIQLLAVWALGARRSRRSIGARIEPYHSNVQTMRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PD6</accession>
    <name>Q63PD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004203374.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110033.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0009"/>
    <dbReference type="EnsemblBacteria" id="CAH37452">
        <property type="protein sequence ID" value="CAH37452"/>
        <property type="gene ID" value="BPSS0009"/>
    </dbReference>
    <dbReference type="GeneID" id="56596752"/>
    <dbReference type="KEGG" id="bps:BPSS0009"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6004"/>
    <dbReference type="eggNOG" id="COG3558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRFQYEC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="18785" checksum="0B15D1A08117DB10" modified="2004-10-25" version="1">MSDSTEIRPPVPPFTRETAIQKVRAAEDGWNTRDPERVSLAYTPQSKWRNRAEFATGRAEIVALLRRKWTREIDYRLIKELWAFTGNRIAVRFAYEWRDDAGNWFRSYGNENWEFDENGLMAHRHACINDMPIREADRLFHWPLGRRPDDHPGLSDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PX9</accession>
    <name>Q63PX9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative flavoprotein (Regulator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197907.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109839.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3245"/>
    <dbReference type="EnsemblBacteria" id="CAH37256">
        <property type="protein sequence ID" value="CAH37256"/>
        <property type="gene ID" value="BPSL3245"/>
    </dbReference>
    <dbReference type="GeneID" id="56594584"/>
    <dbReference type="KEGG" id="bps:BPSL3245"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1989"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVGTGMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="191" mass="19696" checksum="949A8B8009C829C1" modified="2004-10-25" version="1">MSNLVIVYHSGYGHTKKLAESVLAGAREAGANARLVAVGDLDDAGWAALDAADAIVFGAPTYMGGPSADFKKFADATSKAWFGQKWKDKIAAGFTNSASMNGDKFSTIQYFVTLAMQHGMVWVGTGLLPANTKAATRDDLNYAGGFTGLLAQSPSDASPDEAPAGGDLGTAKAFGARVATATARWLAGNGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q17</accession>
    <name>RS3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">BPSL3207</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185240.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109801.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q17"/>
    <dbReference type="SMR" id="Q63Q17"/>
    <dbReference type="STRING" id="272560.BPSL3207"/>
    <dbReference type="PRIDE" id="Q63Q17"/>
    <dbReference type="EnsemblBacteria" id="CAH37218">
        <property type="protein sequence ID" value="CAH37218"/>
        <property type="gene ID" value="BPSL3207"/>
    </dbReference>
    <dbReference type="GeneID" id="56594549"/>
    <dbReference type="KEGG" id="bps:BPSL3207"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2031"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130092" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="266" mass="29919" checksum="92B4A519A53E7D23" modified="2004-10-25" version="1">MGQKIHPTGFRLAVSRNWASRWYANNNNFAAMLQEDIGVREYLKKKLKNASVGRVVIERPAKNARITIFSSRPGVVIGKKGEDIELLKTELQRRMGVPVHVNIEEIRKPETDAQLIADSITQQLERRIMFRRAMKRAMQNAMRLGAQGIKIMSAGRLNGIEIARTEWYREGRVPLHTLRADIDYATSEAKTTYGIIGVKVWVYKGDTLGRNDAPVVEEVTEDKRPRRNARPGDRRPRRDGEGGAPGARRGGPRRGAGKPEDGKTGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q93</accession>
    <name>HIS3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="1">PRA-CH</shortName>
            <ecNumber evidence="1">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisI</name>
        <name type="ordered locus">BPSL3132</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109725.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q93"/>
    <dbReference type="SMR" id="Q63Q93"/>
    <dbReference type="STRING" id="272560.BPSL3132"/>
    <dbReference type="EnsemblBacteria" id="CAH37142">
        <property type="protein sequence ID" value="CAH37142"/>
        <property type="gene ID" value="BPSL3132"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3132"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3581"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000229814" description="Phosphoribosyl-AMP cyclohydrolase">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <sequence length="138" mass="15830" checksum="F6834C363BD6F408" modified="2004-10-25" version="1">MMNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QB9</accession>
    <name>Q63QB9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPW_gp25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109699.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3104"/>
    <dbReference type="EnsemblBacteria" id="CAH37115">
        <property type="protein sequence ID" value="CAH37115"/>
        <property type="gene ID" value="BPSL3104"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3104"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3556"/>
    <dbReference type="eggNOG" id="COG3518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IERHEPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017737">
        <property type="entry name" value="TssE1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03357">
        <property type="entry name" value="VI_zyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="170" mass="19209" checksum="B4F9BAEE079FDE4C" modified="2004-10-25" version="1">MPRSRFACCPMKRFEPSFLDKLFDDEPHVPAPAAMRQLSLEELKNTVARDVEAILNTRIALTEEDLAELPECQRSVLTYGLNDFAGLSLASHYDRTFICKSIQQAIARHEPRLQQVQVAFELNEQSTNALYFAIQALLVVHPAEEPVTFDAMLQPSTLQYSVTRSRAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QC0</accession>
    <name>Q63QC0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109698.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3103"/>
    <dbReference type="EnsemblBacteria" id="CAH37114">
        <property type="protein sequence ID" value="CAH37114"/>
        <property type="gene ID" value="BPSL3103"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3103"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3555"/>
    <dbReference type="eggNOG" id="COG3519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTCYPVE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028304">
        <property type="entry name" value="UCP028304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="608" mass="67887" checksum="233386FE1A1CEA3C" modified="2004-10-25" version="1">MPYYERELSFLRRYSLEFANRYPKIAARLAQTGEQCEDPHVERMIESFALLGARINKKLDDEYPEFTEALVEVLYPHYLRPFPSCSIAQFGAPHAFAELTEPRIVERGTELKSRAIRGVQCRFRTAYDVTLAPIRLADARYGSVAVAPAAARLPGNATGVISIAFESTSPQLDLAALKLGKLRAHLHGEQSFVAALADCLFAHALACYVEPDRGGRWIALGKTPFEHAGFDETDALIDYPARSHPAYRLLTEYFAFPDKFNFVDFDLGALARRAGPCRQLTLHIALRDVRGDSHVARLLDLLSASHFRLFCTPVVNLFRQHGEPIRVDHRAVSYPVIGDARRAFAYEVYSIDSVHLVRQRADRETLVEFRPFYSLHHGEAAQAGHYWFARRNDDVARKSPGYETEISVVDVDFEPGAPQTDTLSLDLTCTNRDLPAALATGLDGGDLFIDGGEQPGPIALLRRPTPSARFERGHAAHWRLVSHLALNHVSLAEEGLAALKEALVLYDLRRSAVSTRHIDGIVGIEQKSAVQWLPGKPFATFVRGVEIRLAIDDEHFVGSSLATFVRMIDAFFGLYVHLNSFVQLIVVSRRTGEEIMRCKPRSGESILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QY2</accession>
    <name>Q63QY2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109486.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2892"/>
    <dbReference type="EnsemblBacteria" id="CAH36902">
        <property type="protein sequence ID" value="CAH36902"/>
        <property type="gene ID" value="BPSL2892"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2892"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3303"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWADTEL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="469" mass="51077" checksum="21E690593F9172E7" modified="2004-10-25" version="1">MMNQPTEPALALDVYRQRRDRVLASLRAQGGGVAIVPTAPEVPRNRDSDYPYRHDSYFYYLTGFAEPDALLVLDASAAGDAPRSILFCRAKNPEREIWEGFHFGPEAARDAFGFDAAFPYDALDAEMPRIVADAPALHYRFGVSAAFDARLNGWLDAVRARARAGVAAPGAAFDLGPLLDDMRLVKDAHEQATMRRAADISALAHRRAMAACRPGIREYELEAELLYTFRRHGAQSPAYGSIVATGANACVLHYPAGNAVVADGELVLIDAACELDGYASDITRTFPANGRFSGPQRALYDIVLAAQEAAIAATRAGTQFDAPHDAAVRVLAQGMLDTGLVPKTRFASVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERGAPRDDDGALPSRVLHPGMALTIEPGLYVRPGEDVPQAFWNIGIRIEDDAFVTPTGCELITRGVPVAADEIEALMRDARPAPRPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R82</accession>
    <name>Q63R82_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative capsular polysaccharide biosynthesis dehydrogenase/reductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wcbP</name>
        <name evidence="1" type="ordered locus">BPSL2791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938563.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109386.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2791"/>
    <dbReference type="EnsemblBacteria" id="CAH36800">
        <property type="protein sequence ID" value="CAH36800"/>
        <property type="gene ID" value="BPSL2791"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2791"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2518"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGQIALI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="27904" checksum="AB02E1566BA1B3CA" modified="2004-10-25" version="1">MSDSTGPRHIAITGASAGLGRALARAYARPGVVLSLGGRDAVRLEESAADCRARGATVFVASIDVRDADAMRRWLEQFDDAHPIHLLIANAGVASTLAHGGDWEARERTAAIVDTNFYGAMNAVLPVIDRMRARGSGQVALISSLAALRGMAISPAYCASKAALKAWGDSVRPVLKRDGIRLSVVLPGFVKTAMSDVFPADKPLLWSPDKAAQYIQRGIAARRAEIAFPALLALGMRLLPLLPAVMADAILGRLSYLPREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R98</accession>
    <name>Q63R98_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522188.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109370.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2775"/>
    <dbReference type="EnsemblBacteria" id="CAH36784">
        <property type="protein sequence ID" value="CAH36784"/>
        <property type="gene ID" value="BPSL2775"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2775"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2538"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGRWRYT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="178" mass="19130" checksum="AA14DCD897947F0A" modified="2004-10-25" version="1">MRTTLKRTLDAIAEDRRRNAFFKTRCVVVFFRIANYLACRSRLTLALGAPVIALYIVVCDWIMGIEIPVKTKIGKGLTLYHGTGLVINGYCEIGERCVIRHGVTIGNTLRPDGTYSGVPSVGDDVEFGAHSIALGEIRIGHRARVGAGAVLLRDVPDGGVAVGVPARVLENGKEQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RB2</accession>
    <name>Q63RB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527641.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109356.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2760"/>
    <dbReference type="EnsemblBacteria" id="CAH36768">
        <property type="protein sequence ID" value="CAH36768"/>
        <property type="gene ID" value="BPSL2760"/>
    </dbReference>
    <dbReference type="GeneID" id="56528437"/>
    <dbReference type="KEGG" id="bps:BPSL2760"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3153"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YHASYLR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014166">
        <property type="entry name" value="Tol-Pal_acyl-CoA_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02799">
        <property type="entry name" value="thio_ybgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="18064" checksum="D33D9D0438071D2F" modified="2004-10-25" version="1">MRAMIEPSRQPDAAPDFAWPVRVYYEDTDAGGVVYYANYLKFFERARTEWLRACGIDQSRIADETGAIFIVRHAALDYRAPARLDDALQIVCRIARIGRASVEFEQQAWRGNTLLVAADIRIGCVDRSAFKPTAIPPPVFAALERGPAASDTASRVNGACVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RJ5</accession>
    <name>Q63RJ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative O-antigen methyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wbiD</name>
        <name evidence="3" type="ordered locus">BPSL2677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527597.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109273.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2677"/>
    <dbReference type="EnsemblBacteria" id="CAH36685">
        <property type="protein sequence ID" value="CAH36685"/>
        <property type="gene ID" value="BPSL2677"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2677"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2665"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TKHNDQY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="270"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="574" mass="64809" checksum="B52A8B6D345D7FFC" modified="2004-10-25" version="1">MNSATYQFHYHEYSVYSNVVGLITEFGARDGVHLDIGCGYGAIAEPVRDLGLTYIGFDADEDSLRDLRSRGFEAKRIDLHRLDEVFAEIAATVNGRNVASISIIDTLEHITNGPALLDRLREFAEQRSILLVVSVPNGGHRDLGAKLLAGHWDYTEVGLLDHTHVIHHTDRLLAAMAKRAGWHEVGARDYELESSDQAFPPAHPLLTGNTAASRYLQQIRRASDAFGTVNELVRAYLPGARHDVPLFADPKEARPFLSIVTRTQAKRLGNLRDVLLCLTAQTCQDFEILVVTHKVDGEPYYAVRRIVEDLPESIRNRARVLRCDRGGRTAPLNDGFAAARGHYVAILDDDELVFAHWVETFKKLSEKAAGCVLRATAAEQDIVSTGARPDGALGYRTVSAITTPYPAHFDLFEHLSQNYSPPVSLAFPRVAFQELGIRFDESLDTAEDWDFEMRTAFVCGVESSPEITGIYRKWRSGESSFSIHSQDEWRRDYEKIVTKHNDQYHVFPPGTIKLIVDQRNWIKKLEHDIAVLQGAAKLDPLRRFFVRHPRLYRIVRMTYDNSKIVARRIVRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RK4</accession>
    <name>Q63RK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522259.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109264.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2668"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36676">
        <property type="protein sequence ID" value="CAH36676"/>
        <property type="gene ID" value="BPSL2668"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2668"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2675"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RQIYSAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="30522" checksum="3F95F09E7A673734" modified="2004-10-25" version="1">MTPTFAPPGAARALDDVAVLIPAYNAHDDLLRTLMSLREDAPVRVLVVDDGSTPPIAAPELPGLSVEVLRMPQNGGIERALAAGIDALAARGVRYAARIDAGDLAAPGRLAKQRAYFDTHPSVAGLGTWTQVVSRDGRPLFMLTPSADPATLRRTRFLRSPFVHPSMMLDIAAVKEVGNYRIKYRAAEDLDLFLRLMERYDCANLPELGLYYELNEGGISATKRRRQIASTLALALRYFDPLNPCDWLGVAKNLLHFVTPYSTLQRAKRLLFARRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RQ1</accession>
    <name>Q63RQ1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538642.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109216.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2620"/>
    <dbReference type="EnsemblBacteria" id="CAH36628">
        <property type="protein sequence ID" value="CAH36628"/>
        <property type="gene ID" value="BPSL2620"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2620"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2733"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YFFMLNI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="411" mass="42261" checksum="5B4FEBC48CE0CAE7" modified="2004-10-25" version="1">MPHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIAGGFGVTAAAAQRTLTSFMAGFSIGMLLYGPLSDTYGRRPVLLGGIALFTLASVGCFVAGSIDMLIAVRFLQAFGAGAASVLARAIARDAHEPADAAKVLSMVAIVTAIGPLLAPLIGGQVLRFSGWRGVFVVLALFGAVCATAAYLRVPETWPREKRASSAVLNSFAAYGRILVDPVAWGHMLCGGMAFASMFAYITATPFVYIDYFHVSPQHYGLLFGLNVIGIMLGNFLNARLVGRVGSLKIIAGASLLSGAASFAVAFFALTGLGGLWSIVASLFFVVGVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALASAAIGALANGTPFAMGVTIGATGLLCLGGRMLVLRWHGRPVKGALGRVDAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RS1</accession>
    <name>SYS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">BPSL2600</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186129.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109196.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RS1"/>
    <dbReference type="SMR" id="Q63RS1"/>
    <dbReference type="STRING" id="272560.BPSL2600"/>
    <dbReference type="EnsemblBacteria" id="CAH36608">
        <property type="protein sequence ID" value="CAH36608"/>
        <property type="gene ID" value="BPSL2600"/>
    </dbReference>
    <dbReference type="GeneID" id="56594876"/>
    <dbReference type="KEGG" id="bps:BPSL2600"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2756"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122023" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="433" mass="47607" checksum="08EEE6AB03CE85A4" modified="2004-10-25" version="1">MLDIQLLRKDLDGVAKRLADRGYPLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGDEMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGARFTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISLTNTVRDSIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQKLELPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPVALRPYMGGVERIDAPSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S54</accession>
    <name>Q63S54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL2470A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938337.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109063.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36474">
        <property type="protein sequence ID" value="CAH36474"/>
        <property type="gene ID" value="BPSL2470A"/>
    </dbReference>
    <dbReference type="GeneID" id="56528710"/>
    <dbReference type="KEGG" id="bps:BPSL2470A"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2814"/>
    <dbReference type="OMA" id="CLCAGCA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267495" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="64" mass="6610" checksum="838FFA026BA9850D" modified="2004-10-25" version="1">MIDRRATATRRCSTKFVPMKILVATLLAVFVCTGCASGGAGGSGAGTGRIEMYGTIDQGVTIRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S82</accession>
    <name>PLSX_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsX</name>
        <name type="ordered locus">BPSL2443</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192749.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109035.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S82"/>
    <dbReference type="SMR" id="Q63S82"/>
    <dbReference type="STRING" id="272560.BPSL2443"/>
    <dbReference type="EnsemblBacteria" id="CAH36446">
        <property type="protein sequence ID" value="CAH36446"/>
        <property type="gene ID" value="BPSL2443"/>
    </dbReference>
    <dbReference type="GeneID" id="56596358"/>
    <dbReference type="KEGG" id="bps:BPSL2443"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2947"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189857" description="Phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="368" mass="38940" checksum="523704833D8710E5" modified="2004-10-25" version="1">MTVKLTIDCMGGDHGPSVTVPAAVKFVRSHPDAHLMLVGIESAIRAQLKKCKALGEPALSVVPATEVVAMDDPVEVALRKKKDSSMRVALNHVKEGAAQACISAGNTGALMAVSRYVLKTLPGIERPAIAFALPNPTGYTMMLDLGANVDCEPQHLLQFAEMGHALVAALEGKERPTIGLLNIGEEVIKGNETIKRAGELLRASTLNFRGNVEGNDIYKGTVDVIVCDGFVGNVALKTSEGLAQMLADIIKEEFSRSLLSKLMAILALPVLLRFKKRVDHRQYNGAALLGLRSLVIKSHGSADAYAFEWAIKRGYDAVKNGVLERLSRAMAENAAPLGESGRDANGAGQASPSAGQPAEPSAALSSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SC0</accession>
    <name>Q63SC0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic ligand binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191212.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108996.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2404"/>
    <dbReference type="EnsemblBacteria" id="CAH36407">
        <property type="protein sequence ID" value="CAH36407"/>
        <property type="gene ID" value="BPSL2404"/>
    </dbReference>
    <dbReference type="GeneID" id="56596315"/>
    <dbReference type="KEGG" id="bps:BPSL2404"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2991"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGWDSEK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266287" evidence="1">
        <location>
            <begin position="27"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="31"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="382" mass="39995" checksum="39AABDFE4001C490" modified="2004-10-25" version="1">MRLRSSLPSLALAAAFACGATGAARAADETPVRIGFAAPLTGVNAGYGKDLQNGVQLALDDARAQKITIAGKPARFELVVEDDQADPRIGVQAAQSLVDKKVSVVVGHFNSGTTIPASVVYDKAGIPVIDPAATNPVITSRGLANVFMVIATDGQNAGNAGRYAVDVTKAKRIAIVDDRTAFGQGEADEFDKAVKAAGAAIVAREYTSNQAVDFRAQITSLKSKNVDLVFFGGLDSLAANFIKQMKQLGLNAQFVGGGGVKDAEFIKIAGPAAEGAMAWEYGRPLDQLPQGKDFESRFKKRFGVDVLSYAQFGYDATWAAIKAMQAAGTTDPSGYRPALKKIDFEGITGRISFGGDGSLKSGMSTLYQVKSGAWQTIVTKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SC9</accession>
    <name>Q63SC9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108987.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2395"/>
    <dbReference type="EnsemblBacteria" id="CAH36397">
        <property type="protein sequence ID" value="CAH36397"/>
        <property type="gene ID" value="BPSL2395"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2395"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2730"/>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EVWGYRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037873">
        <property type="entry name" value="BamE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007450">
        <property type="entry name" value="Lipoprotein_SmpA/OmlA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04355">
        <property type="entry name" value="SmpA_OmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267501" evidence="2">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SmpA_OmlA" evidence="3">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="186" mass="20896" checksum="CD5DDC2B38D224F0" modified="2004-10-25" version="1">MTMFRFRILPAAMLGAALALAGCDDRQSEQTVQRFKDFFNAIKPAPLFLKGLTPGVTTEAEIRGQMGRPETERVYTDGSKRLEYPRGPMGNETYMVDIDASGRFVAATQVLTAANFAKIRPGMTQDEVRRLLGKPTEVARYPLKPETVWSWRWLEDGVNQDAFFNVHFGPDGLVYTTSRSDILKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SE0</accession>
    <name>Q63SE0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative histidine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192955.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108976.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2383"/>
    <dbReference type="EnsemblBacteria" id="CAH36385">
        <property type="protein sequence ID" value="CAH36385"/>
        <property type="gene ID" value="BPSL2383"/>
    </dbReference>
    <dbReference type="GeneID" id="56596291"/>
    <dbReference type="KEGG" id="bps:BPSL2383"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3020"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMGEAIN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005768">
        <property type="entry name" value="Lys_Arg_Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01096">
        <property type="entry name" value="3A0103s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266751" evidence="5">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="31"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="28323" checksum="593BB31F20BEEB7F" modified="2004-10-25" version="1">MKLNWRKMAAHAVVTATALAAGSAFAADLKEIRFGVEASYAPFEYKTPDGKLAGFDIDIGNAVCAKLKVKCVWVENAFDGLIPALQARKFDAINSDMTITEQRRKAIDFTDPIYTIPNQLIAKKGSGLLPTTASLKGKRIGVLQGTIQEAYAKKRWAPAGVEVVPYQTQDLAYEDLKSGRLDATFQDSEAGAKGFLSKPQGAGFAFAGDHVSDAEILGTGVGFGMRKNDAQLKSAVNQALKELKADGTIDGLAKKYFSVPVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SM5</accession>
    <name>Q63SM5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524720.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108891.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2295"/>
    <dbReference type="EnsemblBacteria" id="CAH36298">
        <property type="protein sequence ID" value="CAH36298"/>
        <property type="gene ID" value="BPSL2295"/>
    </dbReference>
    <dbReference type="GeneID" id="56528894"/>
    <dbReference type="KEGG" id="bps:BPSL2295"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3134"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIERTYS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="270" mass="29723" checksum="4F348760DE13FB02" modified="2004-10-25" version="1">MSNPNPDSKTSIQVIERMMRLLDALAAHSDPVSLKELAQRTELHPSTAHRILNDMVTCRLVDRSDPGTYRLGMRLLELGNLVKARLSVRDAALMPMRELHRLTGQTVNLSVRQGDEIVYIERAYSERSGMQVVRAIGGRAPLHLTSVGKLFLAADETSRVRAYATRTGLAGHTQNSITDLPKLERELTLVRQQACARDNEELELGVRCIAAGIYDDSGKLVAGLSLSAPADRLQDAWLGQLSRTALTISESLGYRPETAKEMDAPAQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T65</accession>
    <name>Q63T65_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
            <ecNumber evidence="6">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ordered locus">BPSL2104</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EC" id="3.4.16.4" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108701.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2104"/>
    <dbReference type="EnsemblBacteria" id="CAH36107">
        <property type="protein sequence ID" value="CAH36107"/>
        <property type="gene ID" value="BPSL2104"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2104"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2386"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ADWAGKT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031376">
        <property type="entry name" value="PCB_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17092">
        <property type="entry name" value="PCB_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="20" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="23" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="25">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PCB_OB" evidence="26">
        <location>
            <begin position="381"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="24">
        <location>
            <begin position="487"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF17092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAH36107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="852" mass="92300" checksum="E9D3998782DBBC94" modified="2004-10-25" version="1">MLEARLVRRPSDMPIIKRPPSSRATNEHHYSLRRSPAGAYYTDDDDDDERAPRRTGRDGGSRTFGSRVALWFAGLFATLLVVGALIVGYALVVMGPQLPSLDALTNYQPKVPLRVYSADHVLLGEFGEERRSLVRFADIPDVMKKAVLAIEDYRFYEHGGVDFVGILRAGVADLLHGGARQGASTITMQVARNFFLSSEKTYTRKIYEMLLAYKIEKALTKDQILELYMNQIYLGQRAYGFAAAARVYFGKDLKDVTLAEAAMLAGLPKAPSAYNPVVNPKRAKVRQEYILKRMLEIGYITQQQYDQAVKEEIHVRTPGNQYAVHGEYVAEMVRQMMYAQYKDETYTRGLTVTTTINAADQEAAYQAVRRGIMDYERRHGYRGPEGFVALPPAGDERDEAIDDALADHPDNGDLQSAVVLAVSPTAVDVQFVGGATATINGAGLRFAAGALSARASAALKIKPGSIVRVMKDARSAWQIVQLPQVEGALVAVAPQDGAIRSLVGGFDFNKSKFNHVTQAWRQPGSSFKPFIYSASLEKGLGPATIINDAPLYFPPSVPGGQPWEPKDDDQPDGPMPMRTALQRSKNLVSIRILASIGTSYAQDYVTQRFGFDPAKTPPYLPMALGAGLVTPLQLAAGYAVFANGGFKVDPYLIAEVDDARGQALQKAQPVVAGASATRTIDARNAYVMNSLLHTVATAGTGAGTNALGRGDLQGKTGTTNEAKDGWFAGYQQSLVAVAWMGFDQPKSLGSREFGAQLALPIWVNYMRTALNGVPEQQMAMPDGLTTIDGELYYADRTPGAGFVASVDFNPAASPTVSANDALGSAGAAGLTPPPVTPEEKRQIIDMFEGNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T88</accession>
    <name>Q63T88_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL2079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555934.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108678.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2079"/>
    <dbReference type="EnsemblBacteria" id="CAH36080">
        <property type="protein sequence ID" value="CAH36080"/>
        <property type="gene ID" value="BPSL2079"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2079"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.78"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYPNWRL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="740" mass="78172" checksum="B0D1043C05EDBB33" modified="2004-10-25" version="1">MTADPRHPSIVELADAAGLDAHWIDASGFARRVGDDMLAALLDALGYPCDTRAARAESAARLAAHAQAAPRLVTGDVDAPLTLPASLGRPGACYRVTLENGDAVAGRFAQPAGAAVLPPLATPGYHVLDTGEQRATLAIAPPSAWTPADAMRAAAAGGRERPPPWGLAAQLYGLRREADGGIGDFTALAACARAAARRGAHALAISPTQAAFPALPEHDSPYSPSSRLWRNAAYIDVETVLGAHAARAAIADAGLAAQWSALTRAPLVDWPGAVPAKLRVLRLLFDRWRAQAPTGADAGPRAFARFRARHAGALDAHATFDALQACCIDNGIGADWRRWPPAWRTPDAPDVAAFARAHAHDIAFYAFLQWQAARGLAAAQRAARGRGMAIGLIADLPVGCDAAGSDAWRDGDAMLRGLSIGAPADPFNARGQAWGVTTWTPTALRARGFAPFVECLRAGFAHAGGVRIDHVLGLARLWVVRDGAPPRDGAYLRYPRDDLLRLAALESFRHRAIVIGEDLGTVPADFRARIAARGIVGLRALWFERDPAGAFRAPGDWDRHAAATSSTHDLPTVAGWWRGVDLGWRRRAAASASACAPASPLSPASDAEAEANAPPARPGESEVAGPDALPPEVRDMRRAERAALWRALQQAGVAARGQKMPPRDAPPVGAILAYVAQAPAPLAIFPLEDLLALEGQPNVPGPPCGHPNWRRRMPRSVDALFDAPARTRIAAVRRARKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T94</accession>
    <name>Q63T94_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly(3-hydroxybutyrate) depolymerase</fullName>
            <ecNumber evidence="4">3.1.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phaZ</name>
        <name evidence="4" type="ordered locus">BPSL2073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.75" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534909.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108672.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2073"/>
    <dbReference type="EnsemblBacteria" id="CAH36074">
        <property type="protein sequence ID" value="CAH36074"/>
        <property type="gene ID" value="BPSL2073"/>
    </dbReference>
    <dbReference type="GeneID" id="56526437"/>
    <dbReference type="KEGG" id="bps:BPSL2073"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.70"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VAIWHGT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050526">
        <property type="term" value="F:poly(3-hydroxybutyrate) depolymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266302" evidence="2">
        <location>
            <begin position="31"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="350"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="492" mass="50761" checksum="06E716D93B14F454" modified="2004-10-25" version="1">MTRNARRTWQWISGLLAICAAALAALPARADVAAGPGAWSSQQTWGADTVNGGNLTGYFYWPATQPTTPNGKRALVLVLHGCLQSASGDVIDNSRGAGFNWKSVADRYGAIILAPNATGNVYGNHCWDYANTSPNRASGHVGVLLDLVSRFVGDAQYAIDPNQVYVAGLSSGGGMTMVLGCIAPDVFAGIGINAGPPPGTTTLQIGYVPSGYTAQTAANQCKAWAGSKADQFSTQIAGAVWGTSDYTVAQAYGPLDTAAFRLIYGGTFAQGSKVSIAGGGTNTPYSDSNGKVRTHEIVVSGMAHAWPAGAGGDNANYVDATHVNYPAFVMDYWVKNNLRANGAPVQAGTPPTGLTVTNATQTSISLAWNPVANASSYNVYRNGNKVGSSTSTAYTDAGLIAGTAYSYTVTEIDPSLGESAPSPAVSATTQPSFACSATTATNYAHVQAGRAHDSLGIAYATGSNQNMGLDNVFYTNTLAQTSAGYYIIGDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TK4</accession>
    <name>Q63TK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193328.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108562.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1964"/>
    <dbReference type="EnsemblBacteria" id="CAH35963">
        <property type="protein sequence ID" value="CAH35963"/>
        <property type="gene ID" value="BPSL1964"/>
    </dbReference>
    <dbReference type="GeneID" id="56595433"/>
    <dbReference type="KEGG" id="bps:BPSL1964"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4112"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HHIRHVP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17445" checksum="BB1A9F8CFA7B79E3" modified="2004-10-25" version="1">MRVSDILKVKGNTLFTVTPDTPLRSAVDTMAEHDIGSLVVMEYGDLVGILTFREIILRLKANGGSIGEVLVRTVMDEPLTCTPETDIDEVRRMMLERHARYMPVLDKKVLMGVISFYDVAKTVVEAQSFENRMLKAYIRDWPEPDSEERKPLAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TM6</accession>
    <name>SYFA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">BPSL1941</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191909.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TM6"/>
    <dbReference type="SMR" id="Q63TM6"/>
    <dbReference type="STRING" id="272560.BPSL1941"/>
    <dbReference type="EnsemblBacteria" id="CAH35940">
        <property type="protein sequence ID" value="CAH35940"/>
        <property type="gene ID" value="BPSL1941"/>
    </dbReference>
    <dbReference type="GeneID" id="56595483"/>
    <dbReference type="KEGG" id="bps:BPSL1941"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4085"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000126680" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <sequence length="337" mass="37996" checksum="5343093C696E0F5E" modified="2004-10-25" version="1">MDLDQIVADAQQSFEGAADITTLENEKARFLGKSGALTELLKGLGKLDPETRKTEGARINVAKQQVEAALNARRQALADALLNQRLAAEAIDVTLPGRGAGAGSLHPVMRTWERVEQIFRSIGFDVADGPEIETDWYNFTALNSPENHPARSMQDTFYVDGKDADGRPLLLRTHTSPMQVRYARMNRPPIKVIAPGRTYRVDSDATHSPMFNQVEGLWIDENVSFADLKGAYTDFLKKFFERDDILVRFRPSYFPFTEPSAEIDMMFEHGKNAGKWLEISGSGQVHPTVIRNMGLDPERYIGFAFGSGLERLTMLRYGVQDLRLFFENDLRFLRQFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TV3</accession>
    <name>LFTR_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="1">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aat</name>
        <name type="ordered locus">BPSL1864</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the L/F-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521636.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108463.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TV3"/>
    <dbReference type="SMR" id="Q63TV3"/>
    <dbReference type="STRING" id="272560.BPSL1864"/>
    <dbReference type="EnsemblBacteria" id="CAH35863">
        <property type="protein sequence ID" value="CAH35863"/>
        <property type="gene ID" value="BPSL1864"/>
    </dbReference>
    <dbReference type="GeneID" id="56529557"/>
    <dbReference type="KEGG" id="bps:BPSL1864"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3998"/>
    <dbReference type="eggNOG" id="COG2360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRQGIFP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000258049" description="Leucyl/phenylalanyl-tRNA--protein transferase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <sequence length="255" mass="28205" checksum="C14DB8299494F85D" modified="2004-10-25" version="1">MVPWLGPDDPFPSVERALGAASGAPGLLAASADLLPSRLIDAYRRGIFPWYSDGQPVLWWSPDPRMILVPAEFRISATFRKTLKRVLREPRWEIRVDCDFAGVMRACAQAPRRGQRGTWITAEIIDAYSSLHRAGDAHSIETWLDGRRVGGLYGVSFGRMFFGESMYAHASDASKIALAALVAHLREHRVEMIDCQQNTSHLASLGGREIARKTFVAHVRRAVAEPPIPWRFDKRVVAGLLGQAASATAADAFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U35</accession>
    <name>Q63U35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative iron transport-related exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAH35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108381.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1781"/>
    <dbReference type="EnsemblBacteria" id="CAH35780">
        <property type="protein sequence ID" value="CAH35780"/>
        <property type="gene ID" value="BPSL1781"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1781"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3889"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIWMFGG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266585" evidence="1">
        <location>
            <begin position="33"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="61"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="342" mass="36598" checksum="BBD967D2ED5A495E" modified="2004-10-25" version="1">MRGARAARPLAAVAAFAALVAGALAFAPAAHAGEPSAVCRPLADDPTVSQFSRTLPARPARIVVLEFMFAEDLAALDITPVGMADPAYYPIWIGYDDARFARVSDVGTRQEPSLEAIAAAKPDLILGVGLRHAPIFDALSRIAPTVLFKYSPNYIEDGRQVTQYDWARAILRTIGCLTGRARDARAVQARVDAGLARDARRIAAAGRAGERVAWLQELGLPDRYWAFTGNSASAGIARALGLEPWPGEPTREGTAYVTSEDLLKQPDLAVLFVSATEPGVPLDAKLDSSIWRFVPARRAGRVALVERNIWGFGGPMSALRLADEMTQRVLALPKPAAGAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U46</accession>
    <name>Q63U46_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hoxN</name>
        <name evidence="9" type="ordered locus">BPSL1770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004266608.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108370.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1770"/>
    <dbReference type="EnsemblBacteria" id="CAH35769">
        <property type="protein sequence ID" value="CAH35769"/>
        <property type="gene ID" value="BPSL1770"/>
    </dbReference>
    <dbReference type="GeneID" id="56529456"/>
    <dbReference type="KEGG" id="bps:BPSL1770"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3875"/>
    <dbReference type="eggNOG" id="COG3376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGWVLYK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="38609" checksum="22FA87D6B6BA0AF2" modified="2004-10-25" version="1">MLESFLRLFNDSPAELRSKIVGIYAMLIAFNVGAWAWAFAAFHGQPVLLGTALLAYTFGLRHAVDADHIAAIDNVTRKLMHEKKNPLGAGLFFSLGHSSVVILMTVAVALTAATLAERFEGMKAWGGAIGTSVSAFFLLVLAFANLLILISVYRTFRAVRRGEPLVEQDLDILLNQRGFFARIFRPLFAIVSRSWHLYPIGFLFGLGFDTATEIALFGISATQAHGGLSFWSVMALPVLFTAGMTLVDTTDGIMMMGAYRWAFVRPIRKIYYNMTITFVSVLVAIVIGGIEALALIGGKLALKGGVWDFAAMAAEHFGVLGYFVIGLFAASWIVSALIYRIRRYDDIDVTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U82</accession>
    <name>Q63U82_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108334.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1734"/>
    <dbReference type="EnsemblBacteria" id="CAH35733">
        <property type="protein sequence ID" value="CAH35733"/>
        <property type="gene ID" value="BPSL1734"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1734"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1945"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPKVAQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="515"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="679" mass="73518" checksum="8E53A07A471F5F59" modified="2004-10-25" version="1">MSARPRPASDRRLSQSDRSSCMAVRDIHDIEQIERVPLHARALPANTLQVFDERAAKTPDAPALTFFLDAGRLDRSHTWTFAELRADIVRTANVLASVGIGAGDVAAFVLPNLPDTHFAIWGGEAAGIAMAINPLLDGAQIAELVDAARAKVLICVAPTPGVDIWPKLAPHLDAMPTVETVIWVDLRPYVSLPKRAALAWIERREKARLRGARVRIVNLHAEMRRQPGDRLIRPRAIGPDEPSSYFCTGGTTGRPKIAVRTHGSEVFDVWAASETQARDDEGARTVFCGLPLFHVNGQLVTGLMAWLRGHHVVLGTPQGYRGKNVIARFWAIVEAYRINAFSGVPTLFAALLQQPVGRHDIGSLEYAACGAAPMPVELARSFERTTGVKIVEGYGLTESACIASLNPLDGERRIGSIGLRLPYQRMRAVIVDDTGRYVRDALVDEVGLIALAGPNVFRGYLDPAHERGLWIDIAGERWLNTGDLGRRDAHGYFWLVGRKKELIIRGGHNIDPRIIEDALAAHPAVALAAAIGRPDAHAGELPVAYVQLKAGASADEAALLAFAADAIAERAAVPKHVRILEAVPTTAVGKIFKPQLQRLEIADVVAACARDAQVALERVDVVQDARRGLVAQVAVRGAREALAERLARYAFPVDWSGDGAHARASEAQRDAAAARERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UD2</accession>
    <name>Q63UD2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative outer membrane porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521477.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108284.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1674"/>
    <dbReference type="EnsemblBacteria" id="CAH35673">
        <property type="protein sequence ID" value="CAH35673"/>
        <property type="gene ID" value="BPSL1674"/>
    </dbReference>
    <dbReference type="GeneID" id="56529374"/>
    <dbReference type="KEGG" id="bps:BPSL1674"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3754"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FANRESY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001702">
        <property type="entry name" value="Porin_Gram-ve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00182">
        <property type="entry name" value="ECOLNEIPORIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266785" evidence="7">
        <location>
            <begin position="19"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="8">
        <location>
            <begin position="7"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="38735" checksum="DAB24FD28F5E291E" modified="2004-10-25" version="1">MKKLLIALPLAAAATTHAQSSVTLYGVLEDGVDYVSNVQGKHLVQLASGVTAGSRWGVRGTEDLGGGLSAIFRLESGFDINSGRLGSGLAFSRNAYVGVGDAKLGTLTLGRQWDSIVDYVEPFTLNGNIGGYYFAHPNDMDNTDNGFPISNAVKYRSPTIAGFTFGGLYAFGGQPGRFSDNATFSVGANYAAGPVGFGIGYLRINNPGVSTQGYQNYPGFTNAVYGNYLDAARAQKVFGVGASYQVVQWLKLLADFTNTNFQQGSAGHDATFQNYELSALVKPTPAVTIGAGYTYTTGRDHATNAEPKYHQFNLSVEYALSKRTSVYAMGAFQKAAGDAPVAQIAGFNPSGNQKQAVGRAGIRHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UI0</accession>
    <name>Q63UI0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540128.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108236.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35621">
        <property type="protein sequence ID" value="CAH35621"/>
        <property type="gene ID" value="BPSL1622"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1622"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1829"/>
    <dbReference type="OMA" id="TGNIDIY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266339" evidence="1">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="27043" checksum="86CA8ED096A08D55" modified="2004-10-25" version="1">MKSSKISKTLICSLLAFSATAFSIHPVLAASPQGGKIATTIQAAQGQTDIAALFKKTNFQMDSAAEYGKVMQAIAANESAAVTYVQDSRLSATEVQTTHPIWSGVQNGDRLGVSWSGGDFQHQRIFVYEGNGNAGKWKKAEAADIPLKQGGAPSILNQTPLMPLMPQQQVRETSASAKSVADVVSVSLYRRVTGNIDIYTVKVGSRIQGIYGVGMTAPGWIQADGVGTDIVVFQVRASGTPGLFYSGVASATVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63US7</accession>
    <name>Q63US7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ordered locus">BPSL1519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205018.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108139.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1519"/>
    <dbReference type="EnsemblBacteria" id="CAH35520">
        <property type="protein sequence ID" value="CAH35520"/>
        <property type="gene ID" value="BPSL1519"/>
    </dbReference>
    <dbReference type="GeneID" id="56595742"/>
    <dbReference type="KEGG" id="bps:BPSL1519"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1707"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="196"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="392" mass="42861" checksum="3C10BF56D61BFEBC" modified="2004-10-25" version="1">MTSDNLINAALVGIDFGKTDFEASLEELSLLASSAGAHPAVTLTGRRSSPDAALFVGSGKADELRLACEANDVEIVIFNHALAPAQQRNLERVLNRRVIDRTSLILDIFAQRARSHEGKLQVELAQLQYLATRLIRAWTHLERQKGGIGLRGPGETQLETDRRLIGERIKMLKSRLDKLRRQHHTQRRQRARSGTLSVSLVGYTNAGKSTLFNALTKAQAYAADQLFATLDTTSRRVYLGDEVGQIVVSDTVGFIRELPHQLVAAFRATLEETIHADLLLHVVDASSAVRLEQIEQVNDVLREIGADSIRQILVFNKIDAVPELAARGGAVERDEYGNISRVFLSARTGQGLDSLRAAIAEIATAEHLVGAAPLDGAPALPHEDHPVSEHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V00</accession>
    <name>Q63V00_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108066.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63V00"/>
    <dbReference type="STRING" id="272560.BPSL1444"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35446">
        <property type="protein sequence ID" value="CAH35446"/>
        <property type="gene ID" value="BPSL1444"/>
    </dbReference>
    <dbReference type="GeneID" id="56595819"/>
    <dbReference type="KEGG" id="bps:BPSL1444"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3467"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GEIADHQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="354" mass="40063" checksum="702774BC52833142" modified="2004-10-25" version="1">MRIAQIAPLTESVPPKLYGGTERVVSYITEALVDLGHDVTLFASGDSITRAKLDAVWPRALRLDASIRDRIAPHMLLMETVARRARDFDVLHFHMDYYSFSIFKRQDTPFVTTLHGRLDLPEQQPVFDTFDTAPVISISNAQRHPMPQAKWLTTVYHGLPETLYTPQPVEQSYLAFLGRISPEKRVDTAIRIAQRCGMRIRIAAKIDAADEEYFEREIKPLLALPHVEYIGEIADHEKAAFLSGAHALLFPIDWPEPFGLVMIEAMACGTPVIAFNRGAVPEVIDEGVSGFIVEDEIGAAAAVNRLHMLSRERVRARFDERFTSRRMAQQYVDVYQSLIRAQKRSRFKVIDSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V74</accession>
    <name>Q63V74_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exopolyphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21528"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GppA/Ppx family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107992.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1367"/>
    <dbReference type="EnsemblBacteria" id="CAH35365">
        <property type="protein sequence ID" value="CAH35365"/>
        <property type="gene ID" value="BPSL1367"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1367"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1534"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RISEGCY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006793">
        <property type="term" value="P:phosphorus metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022371">
        <property type="entry name" value="Exopolyphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03706">
        <property type="entry name" value="exo_poly_only"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="5">
        <location>
            <begin position="45"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="519" mass="56658" checksum="125DB8B47AE0A24D" modified="2004-10-25" version="1">MQRRLRAPGENGAPSMVTSPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSRDKMLDRASQERGWEALKRFGERLRDFHPDHVRAVATNTLRVAKNAGEFLAEAQAALGFPIEVIAGREEARLIYAGAAHSVPANAGKRLVVDIGGGSTEFIIGQHYTPLVMESLYIGCVSHSRAFFPAGNVDEYMMRQAELAAKREIQIISGEYKKAGWDQAIGSSGTARALAELVEANGFNDAGVSHGISRGGLERLKRALIKAENVNRLKLVALKPDRVPVLAGGLSIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRAVTVDGFTRRYGVDRAQAARIGALAARFYDQLDEPEGEDRDESRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVLGHAGKLGKLSQSREVEWPLLFCLRLAALLCRRRNDAGLPDINVAQMKKGGYEVHLPSAWVQQNPLTDYSLSQEAAEWEKVGIPYRVVYTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V90</accession>
    <name>Q63V90_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">carB</name>
        <name evidence="17" type="ordered locus">BPSL1351</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193866.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107976.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1351"/>
    <dbReference type="EnsemblBacteria" id="CAH35349">
        <property type="protein sequence ID" value="CAH35349"/>
        <property type="gene ID" value="BPSL1351"/>
    </dbReference>
    <dbReference type="GeneID" id="56595278"/>
    <dbReference type="KEGG" id="bps:BPSL1351"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.129"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="680"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="947"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="947"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="830"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="851"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="853"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAH35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118241" checksum="7DA3ECDA90218BC3" modified="2004-10-25" version="1">MPKRTDINSILIIGAGPIIIGQACEFDYSGAQACKALREEGYKVILVNSNPATIMTDPNTADVTYIEPITWEVVERIIAKERPDAILPTMGGQTALNCALDLFHHGVLEKYGVELIGASPEAIDKAEDRQKFKDAMTKIGLGSAKSGIAHSMEEALKVHADIAAATGGSGYPVVIRPSFTLGGSGGGIAYNREEFEEICKRGLDLSPTRELLIEESLLGWKEYEMEVVRDRADNCIIVCSIENLDPMGVHTGDSITVAPAQTLTDKEYQILRNASLAVLREIGVDTGGSNVQFSINPKDGRMVVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELKNEITGGATPASFEPTIDYVVTKIPRFAFEKFREADSRLTTQMKSVGEVMAIGRTFQESFQKALRGLEVGVDGLDEKTTSRDEIIREIGEPGPDRIWYVGDAFRVGMSREQIFEETAIDPWFLAQIEQIVLKEKALAGRTLASLTKDELHYLKQSGFSDRRLAKLLGATPADVRARRLELNVRPVYKRVDTCAAEFATKTAYMYSTYEEECEAQPTGNRKIMVLGGGPNRIGQGIEFDYCCVHAALAMREDGYETIMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEIVDKEKPVGVIVQYGGQTPLKLALDLEAHGVPIIGTSPDMIDAAEDRERFQKLLQDLGLRQPPNRTARAEDEALALADEIGYPLVVRPSYVLGGRAMEIVHEPRDLERYMREAVKVSNDSPVLLDRFLNDAIECDVDCICDGDAVFIGGVMEHIEQAGVHSGDSACSLPPYSLSTQTVAELKRQTGAMAKALNVVGLMNVQFAIQQVPRPDGSKEDIIYVLEVNPRASRTVPYVSKATSLPLAKIAARAMVGQKLAQQGVTKEVEPPYFSVKEAVFPFIKFPTVDPVLGPEMRSTGEVMGVGATFGEALFKSQLAAGSRLPESGTVLLTVMDADKPKAVEVAKMLHDLGYPLVATRGTAAAIEAAGVPVKVVNKVKDGRPHIVDMIKNGEIALVFTTVDETRAAIADSRSIRMSAQAHKVTYYTTMSGARAAVEGLRYLKDLEVYDLQGLHARLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VD0</accession>
    <name>Q63VD0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="synonym">glmS2</name>
        <name evidence="11" type="ordered locus">BPSL1312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521848.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107936.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1312"/>
    <dbReference type="EnsemblBacteria" id="CAH35309">
        <property type="protein sequence ID" value="CAH35309"/>
        <property type="gene ID" value="BPSL1312"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1312"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.179"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RECALQF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="309"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="482"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="633" mass="68395" checksum="A1E4B0B9311B867A" modified="2004-10-25" version="1">MCGIVGAVARRDVVPNLVDGLKRLEYRGYDSCGVVVYQDRRLVRARSVDRVAALQREISARALSGYTGIAHTRWATHGAPVTANAHPHFSSGVATSGAPAASAAASGGTAQADASPEARARIALSHNGIIENYEALRADLERHGYAFASQTDSEAIAHLVDHLYDGDLFDAVRRALARLRGSYAIAVMCRDEPHRIVGARDGMPLVVGIGDGEHFLASDAIALSNLTDRIAYLENGDVVDIQLHRHWIVDASGRRVERTVHTIAAHVAAADLGGYRYYMQKEIFEQPRAVADTLLDVTSIMPELFGDRAWRALSAADSVLLLACGGSYHAALTAKYWIESIAGLPANVEIASEFRYRDGVPNPKALVVAVSQSGETADVLGAVHAAKRLGMPNTLAICNVPTSALVRECASSFITRAGIEVGVASTKAFTTQLVALFLLTLALAQVRARLSDEDEKRHLHALRHLPEAMSKVLALEPRIIAWSERLARRENMLFLGRGMHYPIALEGALKMKEISYIHAEAYAAGELKHGPLALVSDEMPVIAVAPNDRLLEKLRSNMHEVSARNGRLFVFADVDCAIASAPGLDVIRLTEYYGPLSPILHAVPMQLLAFHAALARGTDIDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VG9</accession>
    <name>Q63VG9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSL1276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107897.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1276"/>
    <dbReference type="EnsemblBacteria" id="CAH35270">
        <property type="protein sequence ID" value="CAH35270"/>
        <property type="gene ID" value="BPSL1276"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1276"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1416"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QSGNLIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="28345" checksum="357FDC75FD126948" modified="2004-10-25" version="1">MPAMLLELNAVTLAYDTPRGRRTIVDRLSLALERGAIGCLLGASGCGKTTVLRAIAGFEPVRAGEIVLAGAALASRDADVPPEKRRVGMMFQDYALFPHLSAQQNVEFGLRRMPKGPRRARAAQMLELVGLADAANAYPHELSGGQQQRIALARALAPSPALLLLDEPFSNLDVDTRERLAFEVRDILKAAGHTALFVTHNQAEAFALADRIGVIDDGRLAQWDTPYNLYHRPANAFVADFVRRDALADERRRALERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VH0</accession>
    <name>Q63VH0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202045.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107896.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1275"/>
    <dbReference type="EnsemblBacteria" id="CAH35269">
        <property type="protein sequence ID" value="CAH35269"/>
        <property type="gene ID" value="BPSL1275"/>
    </dbReference>
    <dbReference type="GeneID" id="56595191"/>
    <dbReference type="KEGG" id="bps:BPSL1275"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.235"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVSGDYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="17586" checksum="138963E0327581CA" modified="2004-10-25" version="1">MDAIDRKLLELLQEDATLPIAELAQRVNLSQTPCWKRIQRLKETGAIRAQVALCDPRRLGVGTTVFVAVRTNQHTEEWAARFTQVVRDMPEVVEVYRMSGETDYLLRVVVADIDDYDRIYKKLIRSVPLFDVSSSFAMEQIKYSTALPVRDGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VQ8</accession>
    <name>Q63VQ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107808.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1186"/>
    <dbReference type="EnsemblBacteria" id="CAH35181">
        <property type="protein sequence ID" value="CAH35181"/>
        <property type="gene ID" value="BPSL1186"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1186"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1312"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HEHQPRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="271" mass="27742" checksum="D9079541C54B32C7" modified="2004-10-25" version="1">MPFPSFRPNARAARAEVHAMTNTQRKVVLITGASRGIGRASALLAAARGWSVGINYARDAAAAEATADAVRAAGAQACVVRGDVAHEADVIHMFDAVQSAFGRLDALVNNAGIVAPSLPLADMDIARLKRVFDTNVLGAYLCAREAARRLSTDRGGGGGAIVNVSSIAARLGSPNEYVDYAGSKGAVDTLTLGLAKELGPHGVRVNAVRPGLIATEIHASGGQPGRAERLGAQTPLGRAGDADEVAETIVWLLSDAASYVTGALLDVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WG1</accession>
    <name>Q63WG1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185343.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107555.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0927"/>
    <dbReference type="EnsemblBacteria" id="CAH34922">
        <property type="protein sequence ID" value="CAH34922"/>
        <property type="gene ID" value="BPSL0927"/>
    </dbReference>
    <dbReference type="GeneID" id="56595017"/>
    <dbReference type="KEGG" id="bps:BPSL0927"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.653"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IGLPYGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="38012" checksum="B75151DE98B61B4A" modified="2004-10-25" version="1">MAFNVTLKQSGRQFQVEADETVLAAALRQNVHLPYGCKNGACGSCKGTIVQGQFEQGPHSASALSNDERTRGLALLCCSKPQSDLEVDVREIAGVDGVQVKKLPCRVAALERRADDVIVLKLQLPANERLQYLAGQYIEFILKDGARRSYSMATAPHEEGPIELHIRHMPGGKFTDHVFGPMKERDILRFEGPLGTFFLREDSDKPIVLLASGTGFAPIKAIIEHAHHVKLERPMTLYWGARRKKDLYLLDAAEQWAKEIPNFKFVPVLSEPDASDAWTGRTGFVHRAVIEDLPDLSGHQVYACGAPVMVESAQRDFTQHHRLPADEFYADSFTSAADLAHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WI2</accession>
    <name>Q63WI2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Riboflavin kinase</fullName>
                <ecNumber evidence="12">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">FMN adenylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL0907</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="12"/>
    <dbReference type="EC" id="2.7.7.2" evidence="12"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535897.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107534.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0907"/>
    <dbReference type="EnsemblBacteria" id="CAH34901">
        <property type="protein sequence ID" value="CAH34901"/>
        <property type="gene ID" value="BPSL0907"/>
    </dbReference>
    <dbReference type="GeneID" id="56594763"/>
    <dbReference type="KEGG" id="bps:BPSL0907"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.675"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 12" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="13">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="330" mass="35668" checksum="19B28B741976AEC9" modified="2004-10-25" version="1">MKVFRGLPNAESRAPCALTIGNFDGVHRGHQALLARVRAAADARGLPVCVMTFEPHPREFFNPASAPPRIAMLRDKLEALREHGVDRVVVEHFNHTFASQSPEAFVERTLVHGLHTRWIMVGDDFCYGARRAGDFASLKAAGERFGFEVEQMETLADADGARISSSGVRAALAAGDLDAAARALGHGYAISGHVAHGLKLGRDLGFPTLNLPIAHKRPALSGIFVVRVHGLAPEPLPGVASLGVRPTVDDSGRVLLEVHLLDWHGDAYGKLVRVEFLKKLRDEAKFVDLETLSRAIAQDVVDTRAYFAEHGRAPGSRATGFATSATDRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WI7</accession>
    <name>Q63WI7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550778.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107529.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0902"/>
    <dbReference type="EnsemblBacteria" id="CAH34896">
        <property type="protein sequence ID" value="CAH34896"/>
        <property type="gene ID" value="BPSL0902"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0902"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.680"/>
    <dbReference type="eggNOG" id="COG4705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SRVALFW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="260" mass="27563" checksum="AD53B5B1A8B277A7" modified="2004-10-25" version="1">MNKLPAITLAFWIMKICATTLGETGGDLLSMTLDVGYAYSSLILFSFFIVTLAAQLAATRYRPAIYWAVIVATSTAGTTMSDFMDRTLGLGYAAGSGILVAILLSIFAVWRLQGESLAVTEIRTRKVEVLYWIAILFSNTLGTALGDFLADSSGLGFAGGAFLIGGLLAAIVLAAYFTKVSKVFLFWAAFVLTRPFGATVGDLLTKPVAKGGLGFGTVGSSAILAGVLVALVIYAMFAEAKRVKQARAPRMGWKQPALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WY5</accession>
    <name>Q63WY5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204883.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107381.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0756"/>
    <dbReference type="EnsemblBacteria" id="CAH34748">
        <property type="protein sequence ID" value="CAH34748"/>
        <property type="gene ID" value="BPSL0756"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0756"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NIRLMRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="102" mass="11390" checksum="ACD60DF776918990" modified="2004-10-25" version="1">MNEKLKPGQAALRNRLSRNLKRIRAAQNISQEELGDRAGLHRTYISQVERTVTNVSLDNIYLLAEALGVDPAELLAIEREETGMPADEKSGRKSSRHSPPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WZ5</accession>
    <name>Q63WZ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204873.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107371.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0745"/>
    <dbReference type="EnsemblBacteria" id="CAH34737">
        <property type="protein sequence ID" value="CAH34737"/>
        <property type="gene ID" value="BPSL0745"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0745"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.860"/>
    <dbReference type="eggNOG" id="ENOG5033B3E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NDYRSAD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="26974" checksum="D4B9DB5C8583941E" modified="2004-10-25" version="1">MDDHYLRQLPDDLQTLVQGTEQQSGLVIQVEVDPARGATVACHVDEHGATLLVSGEESFQPASVMHELLHIRRFLVDGVPQIVVNEDYNDWTPELERGLTNLDNGLEHLVIVPEEIFRFPGRREYWAGVMTRKFEEIRVNPLVPDDRRRHALVNWLFTHHVLMEGPQILAADSLVDELGLRQQADAFRDAMIPALAMKQEAVRRCFQRLNIPFAAVALKYIDSRARRSRAVALEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X51</accession>
    <name>Q63X51_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycerol uptake facilitator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glpF</name>
        <name evidence="7" type="ordered locus">BPSL0686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189870.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107315.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0686"/>
    <dbReference type="EnsemblBacteria" id="CAH34679">
        <property type="protein sequence ID" value="CAH34679"/>
        <property type="gene ID" value="BPSL0686"/>
    </dbReference>
    <dbReference type="GeneID" id="56596618"/>
    <dbReference type="KEGG" id="bps:BPSL0686"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.931"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACFPGRK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="238" mass="24909" checksum="FB40FD69C30BCD78" modified="2004-10-25" version="1">MSPYIAEFIGTALLVLLGNGAVANVLLAKTKGKGADLIVIVMGWAMAVFVAVYVTASFSGAHLNPIVTISLALAGKFAWAKVGGYVASQMLGGMAGAFLVWLAYRQHFAKEADPDLKLAVFCTAPAIRSVTHNVLTEAICTFVLILGVLYLASPQVGLGALDALPVGLLVLGIGISLGGPTGYAMSPARDLSPRIMHALLPIPGKRDSDWRYAWVPVLGPLVGGVLAANLYLYLHTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X61</accession>
    <name>Q63X61_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530900.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107305.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0676"/>
    <dbReference type="EnsemblBacteria" id="CAH34669">
        <property type="protein sequence ID" value="CAH34669"/>
        <property type="gene ID" value="BPSL0676"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0676"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.942"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYNVLMF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="390" mass="39553" checksum="43077D3A4F484226" modified="2004-10-25" version="1">MPLPLLALAISAFAIGTTEFVIMGLLPDIARELAVTLPSAGLLVSGYALGVAAGAPLLAVLTSRMPRKVALQLLMAIFIAGNVLCALAQSYGMLMVARVVTSFAHGSFFGIGAVVAASLVSADKRASAIALMFTGLTLANVLGVPFGTFVGQTLGWRATFWIVAALGVASFAGVAALVPKRRDAAGAALSRELRVLRQPQVWLALAMTVLGFGGVFVVFTYIAPILEDVTGFAPRAVSLVLVLFGAGLTIGNTIGGRLADRALMPSLVAILVALIAVMAVFAKTSHMPAAAAVTVFVWGIAAFATVPPLQSRVVEKAAHAPNLASTLNIGAFNVGNAGGAWLGGVALSHGVPLDALPWVAAVVTLAALAVTALAARLDTRVSSGAATAAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X63</accession>
    <name>MIAB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="1">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaB</name>
        <name type="ordered locus">BPSL0674</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190165.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107303.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63X63"/>
    <dbReference type="SMR" id="Q63X63"/>
    <dbReference type="STRING" id="272560.BPSL0674"/>
    <dbReference type="EnsemblBacteria" id="CAH34667">
        <property type="protein sequence ID" value="CAH34667"/>
        <property type="gene ID" value="BPSL0674"/>
    </dbReference>
    <dbReference type="GeneID" id="56596631"/>
    <dbReference type="KEGG" id="bps:BPSL0674"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.945"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000374185" description="tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="143"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="380"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="457" mass="50512" checksum="F68BEB06D39F043B" modified="2004-10-25" version="1">MTKKVYVKTFGCQMNEYDSDKMVDVLNAAEGLEKTDTPEDADIILFNTCSVREKAQEKVFSDLGRVRELKEAKPDLLIGVGGCVASQEGASIVARAPYVDLVFGPQTLHRLPQMIDARRESGRAQVDITFPEIEKFDHLPPARVEGPSAFVSIMEGCSKYCSYCVVPYTRGDEVSRPLDDVLTEVAGLADQGVREVTLLGQNVNAYRGAIAAGSAEIADFATLIEYVADIPGIERIRYTTSHPKEFTQRLLDVYAKVPKLVDHLHLPVQHGSDRILMAMKRGYTVLEYKSVIRKLRAIRPNLSLSTDIIVGFPGETDADFDKTMALVHEMSYDTSFSFIYSPRPGTPAANLADDTPRELKLKRLQHLQATIEENVARISQSMLGKVERILVEGPSRKDPNELAGRTENNRVVNFPAPSAAHPRLIGQMIDVKINHAYPHSLRGELVLAHGDASAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X69</accession>
    <name>Q63X69_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="9">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="9">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">glyQ</name>
        <name evidence="11" type="ordered locus">BPSL0668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189444.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107297.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0668"/>
    <dbReference type="EnsemblBacteria" id="CAH34661">
        <property type="protein sequence ID" value="CAH34661"/>
        <property type="gene ID" value="BPSL0668"/>
    </dbReference>
    <dbReference type="GeneID" id="56596637"/>
    <dbReference type="KEGG" id="bps:BPSL0668"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.952"/>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SYYQFQV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="335" mass="38186" checksum="36A099B1A66E188F" modified="2004-10-25" version="1">MLTFQQIILTLQSYWDRQGCALLQPIDMEVGAGTSHVHTFLRAIGPEPWRAAYVQPSRRPKDGRYGENPNRLQHYYQYQVVLKPAPENILDLYLGSLEALGFDLKQNDVRFVEDDWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLDCKPVLGEITYGLERLAMYLQKVENVYDLVWTEWEEPGPNGPELRRLTYGDVYHQNEVEQSTYNFEQANVELLFTFFNSYEAEAKRMIEAQLALPAYELVLKAGHTFNLLDARGAISVTERAAYIGRIRALSRLVAQAYYDSREKLGFPMIGNPVPGVPGLTTDAQEAAQPAWAPPLKAERKIDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XH7</accession>
    <name>Q63XH7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009928821.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107188.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0562"/>
    <dbReference type="EnsemblBacteria" id="CAH34552">
        <property type="protein sequence ID" value="CAH34552"/>
        <property type="gene ID" value="BPSL0562"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0562"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1087"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SNRPTEQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="125" mass="13677" checksum="D9F8AE535664E861" modified="2004-10-25" version="1">MPTSLASVIGRNIASVRKQRGLTQAAVAEQIDVDAETVSRFERGAVMPGVATLERLCAVLECSWMDLLEGSSGDAQQVAHDIVRLLEPLAGDDRLFLLEQMKVWTSKLLERCPPARRRNRSSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XU9</accession>
    <name>Q63XU9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative molybdopterin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198009.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107066.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0441"/>
    <dbReference type="EnsemblBacteria" id="CAH34429">
        <property type="protein sequence ID" value="CAH34429"/>
        <property type="gene ID" value="BPSL0441"/>
    </dbReference>
    <dbReference type="GeneID" id="56594470"/>
    <dbReference type="KEGG" id="bps:BPSL0441"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1217"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="252" mass="26873" checksum="CCE671B69DD71BF8" modified="2004-10-25" version="1">MNDEQLLRYSRHILVDEIGIEAQQRFLDAHAIVVGAGGLGSPAAMYLAAAGVGTITLVDADTVDLTNLQRQILHATDSVGRKKVESGRDALARLNPDVKVNAVAERVDDAWLNAHVPHASVVLDCTDNFATRHAINRACVAHRVPLVSGAALRFDGQISTFDFREPGSPCYACVFPEDQPFEEVACSTMGVFAPTVGIIGAMQAAEALRVIGGIGATLVGRLMMLDSLRMEWNTMKIARQPDCPVCGAGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y43</accession>
    <name>Q63Y43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106972.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0345"/>
    <dbReference type="EnsemblBacteria" id="CAH34334">
        <property type="protein sequence ID" value="CAH34334"/>
        <property type="gene ID" value="BPSL0345"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0345"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1335"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WENSATV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyoxal_oxid_N" evidence="2">
        <location>
            <begin position="414"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1929" evidence="3">
        <location>
            <begin position="762"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="909" mass="96387" checksum="1DD690C1ABC29F03" modified="2004-10-25" version="1">MKKREEKSLSVSHSRRAFLVWVPASLLVTACGGDNGSSAPASIKKAVAALTGPGGATWTGMGKGGILIQSPYSGAGNFELLAGDEYGMLHCLRRTNDNGAQWMVAVGDGMGSKNSVSGYCHTYSTNYTNIEAAVVDDGAVKTYFRSNSTPWSAHKTISIGDAQGFPAYLQSNRNGAQQLELVVGMRRGGMVHYWRDDKDGFTWKQSSIFGSGQVKGVSVMQGNYIGPDNNANLELVAWVDDRLESWCCEGRAWRKICNIAAGGVGGAPALLQSNYGTKGNFEVLVPLATGGIAHYWRNNDAEGIPWSFTGTIGTGAYVAAGLLQSQNGVKGDFEAIGLRASGKADVFRRGDTLVWENSATVSPFSEGTAADVGVSSHIVDVNVTGINSVLLKNGSVLMFGYYKGGSTNKTIPACIWNPVNDQITAIPSFRNNFCAGQTAMPDGKVLIVGGHIGDTLKDVVVFDPDNHTATLVATMTKGRWYPSTATLPDGQVFIISGTETAGWNTSVNDTWQTYANNALTAPEDVISPFSPYYPKSQTQIDLYPFLFVLPDGKLLVHARNTTRFFDIGTRSWSATLYKTVSDNSRTYPFMGGTAVLPLRPSENYRVKVVVAGGADKSAQIAIGDDSQYDNSVPGMTSCEMLDLGDAAPAWKAIAPLNEGRVMCDLVTLPDGKLFIVGGNKTGKADYGRGPTYRPELYDPQTNTWTLLASTRIARGYHATALLLPDGRIAITGKDGDYQGSGLQYAETRVEIFSPPYLFKGPRPAIQSAPASINHGGSFTLGLSSGTSPEDIGSIVIVACGSATHQINFSHRIVELVFAVSGGALTVNAPPNANIAPPGYYMMFVLSKLGVPSVSSIVHVAAGSAQAASATPEALTRQPRVATVSIEQAGDAPRCAPLTVAEKQSINGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK7</accession>
    <name>Q63YK7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HpcH/HpaI aldolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189570.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106808.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0180"/>
    <dbReference type="EnsemblBacteria" id="CAH34167">
        <property type="protein sequence ID" value="CAH34167"/>
        <property type="gene ID" value="BPSL0180"/>
    </dbReference>
    <dbReference type="GeneID" id="56596698"/>
    <dbReference type="KEGG" id="bps:BPSL0180"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1539"/>
    <dbReference type="eggNOG" id="COG3836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NEGWMVK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="261" mass="27602" checksum="E6ABEEB1A02F692F" modified="2004-10-25" version="1">MSTLTHSLKARLRDGDEPLFGLWLTLASEAATEALAHAGFDWLCIDMEHAPNDSRDVAAQLRALAAAHLPSEPVVRVPAREPWFVKRALDAGARTLMFPGVETADEAAHAVRLTRFQAPDAPDGLRGVAGIVRAAAYGMRRDYVQTANAQIATIVQIESARGVDEAERIAATPGVDCVFVGPADLSASLGHLGDTKHPDVAAALEHVLAAGRRAGVPVGIFAADTAGARQSLEAGFRVVALSADVVWLLRATRQALQEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YX8</accession>
    <name>Q63YX8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-ketoadipyl CoA thiolase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525801.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106687.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0062"/>
    <dbReference type="EnsemblBacteria" id="CAH34045">
        <property type="protein sequence ID" value="CAH34045"/>
        <property type="gene ID" value="BPSL0062"/>
    </dbReference>
    <dbReference type="GeneID" id="56527660"/>
    <dbReference type="KEGG" id="bps:BPSL0062"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1678"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DIIMGCV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="279"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="401" mass="41813" checksum="A0FEF3C15990B81A" modified="2004-10-25" version="1">MEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTRAVDDVVLGCVEPVGEQGACIGRIAVLAAGYAETTAGVQINRFCASGLEACNMAAAQVMSGQSEMAIGGGVESMSRVPMGSSGGAWPVDPAIAIPSYFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAAAQAGWFARSIVPVRDANGLTILDHDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRYPELERIEHVHHAGNSSGIVDGASAVLIGSLEAGKRAGLAPRARIRSFASIGSEPSIMLTGPAYAAQKALERAGMRAADIDLYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAATGLATLCVGAGMGTATIIERI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q66X92</accession>
    <accession>Q63WW5</accession>
    <name>RECA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">BPSL0776</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2004-07" db="EMBL/GenBank/DDBJ databases">
            <title>recA-based PCR-RFLP typing of Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Kiratisin P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AY697975">
        <property type="protein sequence ID" value="AAU08168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189458.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107401.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q66X92"/>
    <dbReference type="SMR" id="Q66X92"/>
    <dbReference type="STRING" id="272560.BPSL0776"/>
    <dbReference type="EnsemblBacteria" id="CAH34768">
        <property type="protein sequence ID" value="CAH34768"/>
        <property type="gene ID" value="BPSL0776"/>
    </dbReference>
    <dbReference type="GeneID" id="56596587"/>
    <dbReference type="KEGG" id="bps:BPSL0776"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.833"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000122675" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <sequence length="356" mass="38173" checksum="12216B8E08F1DEEC" modified="2004-10-11" version="1">MEESKKGSGLTAEKSKALAAALAQIEKQFGKGSIMRLGDGEAVEDIQVVSTGSLGLDIALGVGGLPRGRVVEIYGPESSGKTTLTLQVIAEMQKLGGTAAFIDAEHALDVQYASKLGVNVPELLISQPDTGEQALEIVDALVRSGSIDMIVIDSVAALVPKAEIEGEMGDALPGLQARLMSQALRKLTGTIKRTNCLVIFINQIRMKIGVMFGNPETTTGGNALKFYSSVRLDIRRIGSIKKNDEVIGNETRVKVVKNKVSPPFREAIFDILYGEGISRQGEIIDLGVQAKIVDKAGAWYSYSGEKIGQGKDNAREFLRENPEIAREIENRIRESLGVAAMPQGAGSEAEIMDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HW4</accession>
    <name>Q63HW4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552290.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112308.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2305"/>
    <dbReference type="EnsemblBacteria" id="CAH39791">
        <property type="protein sequence ID" value="CAH39791"/>
        <property type="gene ID" value="BPSS2305"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2305"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5931"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGATYFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266054" evidence="1">
        <location>
            <begin position="23"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="522" mass="55721" checksum="C4A9412C6B897256" modified="2004-10-25" version="1">MKTAIRKLTASLLVAAAAACFAADAPHAPEHLPPGIAWRQGDVDAAFAEAKRTNKPLFLYWGAVWCPSCNQVKSTIFSQQAFKSRSSFFVPVYLDGDTENAQKIGDRFKVRGYPTMILFRPDGTELTRLPGEVDLDRYMQALSIGLNASHPFKRTLAAALKDGARVTPDEWRVLADYSWDTDGDLPVPGERVAATLQALARHARADHANAQALRLDLKAAVSAAAGDPPQQGDVDKAAAAAAVRDALRDPKRARADYDVLVAAPAEVVAYLAGGDAAARALLAKQYDAALARLSTDASLAAIDRTMALHGRVRVARLDARPGAPLPPALADAVRRQTASAVTESTNVYGRQAVVSEAADTLTDAGQFDAADALLKAELVRSPTPYYFMSGLAANAKARGDRAAALDWYRKAYEAASGPATRLRWGAAYFANAVDLAPDDAAQIRRIANDVLTQASQTRNAFYGANRRALTRVVTQLAHWRQRGAHDAAAQAVVKQFEGVCGKLPVGDPQVGTCEGLLKTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I14</accession>
    <name>Q63I14_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552265.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112258.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2255"/>
    <dbReference type="EnsemblBacteria" id="CAH39741">
        <property type="protein sequence ID" value="CAH39741"/>
        <property type="gene ID" value="BPSS2255"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2255"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5858"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="619" mass="63258" checksum="953B5076DAAFF177" modified="2004-10-25" version="1">MSPAERAMTLHAWRRARRILCVRLDNMGDVLMTTPALRALKESGEGRHLTLLTSSAAAPLAAHLPMIDDVWIYDAPWVKHPGADDGAAADVAMIERLLCGGFDAAAIFTVYSQSPLPAAMMCRLAGIALRLAHCRENPYRLLTERIAETEPQVQLRHEVARQLALVREVGATTRDMRLAFEPGDAARRAVRARLRAARLAWRAQAEGGAEGDGRDRAQARGAGACLEPDDAAASAASTRSAAAEANGSDDSFAAHGGNTPIAATASVVPAAAAASVKSTASTDSADSTDSTDSTDSADAADSIASAAAVAASNPNDSTDPPTDLGRWLVVHPGASAASRRWPAERFADVVARVARYFDGVAVTGGAHERALVETVCARAGKRVLPLAGALSIGELGALIEAADLLLANNSGPVHLATALGTPVVDLYALTNPQHTPWRVPSRVLNADVPCRHCYRSVCDQPGHPCLERVSVDDVVAAVRELMRETTGSHGAGGGGAVSPIRGGAARHGTHAGSVRGAAAPCAVRGAAHARDASEPAVSASALAVRAAGAHASDAGLSAAGASARGVSAAGVPVEGGPLADPPHDAPPTPPMPPPRAAVPSTASPRAANVVPITSATART</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I64</accession>
    <name>Q63I64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport related, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS2206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941203.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112208.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2206"/>
    <dbReference type="EnsemblBacteria" id="CAH39691">
        <property type="protein sequence ID" value="CAH39691"/>
        <property type="gene ID" value="BPSS2206"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2206"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5791"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYYITQW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="435" mass="46745" checksum="A56EA0BD39309C26" modified="2004-10-25" version="1">MREQNASGNTRSRIYRKVDIRILGFLAVCYITAYIDRINISFAKLAMQTDLGWSEAVYGLGAGIFFLGYMAFEVPSNLWLTRIGARLTLSRIMVLWGLTSAAMMFATDVTTFYVLRFLLGVFEAGFSPGMLFCLTRWYPQARMARAMAMLLCAGPVGAVIGGPVSTLIMTQLAGAHGLAGWQWLFVLEGLPAVLLGIVLFFTLSERPADAKWLSENEKAILLSELAAAPRAASRHTAFRGVLKDPRIYAMAFSYFAIICGLYAVSFWLPTLLRGAGVKNLLHVGALSALPYLVAIVAMQVIGRRSDRRGERRVHSALALLLSAAALTGTVLAGDRFVVAMVALVAATALMYSSYAVFWAIPADYLKGDAAAGGIALINSIGLFGGFVSPTIIGWIKTATGSLQAGLMAMVALFVAGAIVLLVNRVDANKWSAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IR4</accession>
    <name>Q63IR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative conserved periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552138.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112008.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39481">
        <property type="protein sequence ID" value="CAH39481"/>
        <property type="gene ID" value="BPSS2003"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2003"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5522"/>
    <dbReference type="eggNOG" id="COG3019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ISCHTAE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007332">
        <property type="entry name" value="DUF411"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04214">
        <property type="entry name" value="DUF411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="17573" checksum="600995A42E8EB7BC" modified="2004-10-25" version="1">MAQLPEDKPVSRARRAIAAGLALLPVVAFARKTATKPVVQVWKTPACGCCEDWLSHLKNNGFDVVVHNVEDTSDVRQQAGMPERFASCHTGIVQGYALEGHVPAREIKRLLREKPNAVGLAVPAMPIGAPGMDGPVYNGRHMPYDVLLIKRGGQSSVYQSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IS9</accession>
    <name>Q63IS9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552128.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111993.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1987"/>
    <dbReference type="EnsemblBacteria" id="CAH39465">
        <property type="protein sequence ID" value="CAH39465"/>
        <property type="gene ID" value="BPSS1987"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1987"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5492"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAGHSAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="164"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="540" mass="60312" checksum="39C5CC7B7A7962D3" modified="2004-10-25" version="1">MIPIEHFEVPHLALWKSCAAEVLAHALGVEHRPPAGIDTDHPLMRATDRYCRAMLENRPLDAPAAGSDDEQAVQTYLSYLHHRRAHAHIAGDAQIERDIERQTQQYKFGNPLWQQMYIQYFKYYWQYPYHKGGEPRYRSWQAADAGNGDLRYGVIEWKLPARARVAIVGDIGTGTDVAAAVLVAALKFAPDAILHLGDVYFSGTRFETDHRLIGLVREVLRGNGRRVPFFTVPGNHEYFTGAVSFLHALDSGELVDTPAQRQQASYFCLRTADDGWQFLGLDTGYHGHYMNVAAAAQQATLERLHIGRVETAGEGASPHWPTDRNPYFRHASLADLPVRDTTSPVDQVTVRTDEAVWHLDKLASFPGRSILLSHHQLYSALDVCGIAQHRDASGTPDPADFNREWINTGLWRQFGPTFGDRVAAWIWGHEHNLGIFADAYRPPDWPTEGDEAVRVFKTLPKGRCAGHSAIPVQAGEAPYAQKYPVALKQADLQLDLTDGWYNRGFQILELAGAGKPARLSYFQVAGADPTPLPLFVEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IV5</accession>
    <name>Q63IV5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187606.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111967.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39439">
        <property type="protein sequence ID" value="CAH39439"/>
        <property type="gene ID" value="BPSS1961"/>
    </dbReference>
    <dbReference type="GeneID" id="56596845"/>
    <dbReference type="KEGG" id="bps:BPSS1961"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5456"/>
    <dbReference type="eggNOG" id="ENOG5030N2I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AILMPKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="59" mass="6601" checksum="9701B68665C84977" modified="2004-10-25" version="1">MLYAILTPKAEAPLGYYDSSVTPTPEDMADFLAKTMGFDDRDEWIEAYGVEKLGYAPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW1</accession>
    <name>Q63IW1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphate acetyltransferase/enoyl-CoA hydratase fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524980.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111961.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1955"/>
    <dbReference type="EnsemblBacteria" id="CAH39433">
        <property type="protein sequence ID" value="CAH39433"/>
        <property type="gene ID" value="BPSS1955"/>
    </dbReference>
    <dbReference type="GeneID" id="56529626"/>
    <dbReference type="KEGG" id="bps:BPSS1955"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5446"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ISHAYVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="1">
        <location>
            <begin position="238"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="467" mass="49028" checksum="B3D2B154629832FA" modified="2004-10-25" version="1">MDREILQNRPFDSLAIGDSASLVRTASRDDIDLFAAMSGDVNPAHLDAAFAAHDLFGHVVVHGMWTGALVSAVLGTKLPGPGTIYLDQTLEFRHPVAPGDTITATVTVAEKRPEKRIVLLDTRCTNQDGHVVLRGTATVIAPDTPITWERVPGPEVAVRRHDRYETFVRDAREQPPLRTAIVHPCSPDALRAAIDARDANLIEPILIGPQAKIRAIADAAGVDLAGVPIEAVEHSHAAAARAVEMGGAGEVAALMKGSLHTDELLAAVIGPASRLRTERRISHVYAMDVPAYPKPLLITDAAINIAPTLEQKRDICQNAVDLLHVLGVERPRVAVLAAVETVNPKMPSTLDAAALTVMAARGQIAGAIVDGPLAFDNAVSAVAAMSKGIASPVAGDADVLLVPDLEAGNMLAKQLMYFAGADAAGLVLGARLPIILTSRADSLRVRIASAALAKLVAERTRAGALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J27</accession>
    <name>Q63J27_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111895.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1889"/>
    <dbReference type="EnsemblBacteria" id="CAH39367">
        <property type="protein sequence ID" value="CAH39367"/>
        <property type="gene ID" value="BPSS1889"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1889"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6235"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LQFRGMS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="242"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="346" mass="38031" checksum="87438866A2CD14D9" modified="2004-10-25" version="1">MRASDMPPGRRTMFRTPALCARQTIMPPTPFDPLALREHRLFESRDLDETRERISRVMQPHALLPDGSRHGPSHMDYVRLGGLGIGTIAFGDAMRVHLDAVDGYHLLMFCLTGSAQVRTMGRAFDVDAHTGVLCAPGEPFDAHLSRDCEQFVLRIDAATLAAHAGDAAAALDPVIGIDDSALSAWMQQLQLVARSPELLASASANPRVATRLEQLLLDLLIDGHPPAAPPARRADPAPGFVRRAQEFIGAQLAQPLQLADIAQAAGVPERTLRDGFLQFRGTSPMQYLRQRRLERARELLRTAAPERRIAEIALDCGFAHFGRFAIAYRERFGELPSATLADRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J52</accession>
    <name>Q63J52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941023.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111870.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1866"/>
    <dbReference type="EnsemblBacteria" id="CAH39342">
        <property type="protein sequence ID" value="CAH39342"/>
        <property type="gene ID" value="BPSS1866"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1866"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5325"/>
    <dbReference type="eggNOG" id="COG3133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVRYGWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267244" evidence="2">
        <location>
            <begin position="38"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Rick_17kDa_Anti" evidence="3">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="222" mass="22982" checksum="DBEF189BAB15FD66" modified="2004-10-25" version="1">MNTKPIQTTTTKRAAFTKTTLLLALASAAALSLSACVAPNAYGPYGSQPQYGTPAYAQPSYAQPAYTQPSYAQPDYSQPGYPQQGYTQPGYQQGYQPGYQPGYQPGYSGYSTQYGTIAGIRPIGGATSPSGVAGTVVGALVGGVLGNQIGRGHGRDAATVIGALGGAVAGNQIGQQMGAQPSAYRVDVQLSDGSMRSFDLQTPGDLRPGDRVRVDGNQISRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J68</accession>
    <name>Q63J68_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSS1850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529100.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111854.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1850"/>
    <dbReference type="EnsemblBacteria" id="CAH39326">
        <property type="protein sequence ID" value="CAH39326"/>
        <property type="gene ID" value="BPSS1850"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1850"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6181"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTWADGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266493" evidence="9">
        <location>
            <begin position="30"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="11">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="10">
        <location>
            <begin position="246"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="698" mass="74714" checksum="28CB8740927CD93D" modified="2004-10-25" version="1">MDDHRRIAPPFARRLHPLSLLLAASLAHGETGAPPAERRSDAPPATALAPIFVTANPLGASALSSPTASLSGDALTLRRTDSLGDTLNGLPGVSTTTYGPLVGRPIIRGMDGDRIRLLQNGVAAYDASSLSYDHAVPQDPLSVERIEIVRGPAALLYGGNAVGGVVNTIDNRIPREAITGVSGALDASYGGANNARAGAALVEGGNGRFAFHLDAFGRETDALRIPGHAHSARQRALDGEDASEPYGKLPNSDGRRYGGAAGGSYTWADGYVGASYSGYESNYGSVAETDARLQMRQERVALASEVRNLRGPFSQLKFDFGYTNYQHKEIEDGVTGTTFRNHGYEARVEARHRKLGPFEGALGVQVGQNTFSALGGEALAPTTRTTSVALFGLEQWQATDALKLSAGARIEHVRLDPSANGDDKFGFARSRDFNAGSVSAGALYQLAPAWSLAGNVSYTERAPTFYELYANGPHGATGQYLIGRPDAQKEKAVSTDLALRYASGPNRGSIGVFYSRLRNYLAEYDTGRLVDDDGVPVAPGADDALREAVYRGVRAEFYGVELEGRWRAFERRGHRVDLELSADYTHARNADTGEPLPRIAPLRATLAADYGYGPFGARAQLTHAWAQHRVPEHDLATDGYTSLGVVLTYKLRVGATNWLAYLRGDNLTNQDIRYASSVVRNIAPQGGRSVSIGMRTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J87</accession>
    <name>Q63J87_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exopolysaccharide (EPS) biosynthesis related polysaccharide lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525085.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111835.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1831"/>
    <dbReference type="EnsemblBacteria" id="CAH39307">
        <property type="protein sequence ID" value="CAH39307"/>
        <property type="gene ID" value="BPSS1831"/>
    </dbReference>
    <dbReference type="GeneID" id="56529752"/>
    <dbReference type="KEGG" id="bps:BPSS1831"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5278"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLKRPMR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266915" evidence="2">
        <location>
            <begin position="24"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="391" mass="42656" checksum="2112AF44762FF6C5" modified="2004-10-25" version="1">MLNRSLRPLALAVAAATLLQACATAPGNYLDTSRLDDKDSQSAEHYNVQLITAQLVVSQADAQRKAGPLPPARFVDPMQYVYRIAPQDILGVTVWDHPELTTPQGQSFSSGGNTTQTVAGALQQPYANALPGQADPYGQTVMSDGTIYFPFVGRLHAAGKTVGQVRDELAARLARYVKNPQVDVRVLSYRSQKVQVTGEVKTPGPLAITDVPLTLVDAITRSGGSTNEADLQRVRLTRDGKFYQLDANGMLDRGDVTQNVMLQPGDIVNVPDRGDSRVFVMGEVKTPATVPMLKGRLTIADALTAGGGILDTDANPRQVYVLRDLQDKPNTPDIFRLDMTQPDALMLSSRFQLKPLDVVYVGTAGSVRFNRLLQQIFPTIQSIYYMKQITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J92</accession>
    <name>Q63J92_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552050.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111830.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1826"/>
    <dbReference type="EnsemblBacteria" id="CAH39302">
        <property type="protein sequence ID" value="CAH39302"/>
        <property type="gene ID" value="BPSS1826"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1826"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5273"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRRWGRY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="394" mass="43687" checksum="03DF1B83A6F84BFD" modified="2004-10-25" version="1">MRIAIVTHVVRHNDGQGRVNYEIARAALAENCQVTLVASHVAPELLADARVRWIAVKAGRFWPSNLVKQQVFAIKSAWWLRRHREAYDVLHVNGFISWVRADVNTAHFVHSGWFASRYYPFGLSKGLWSAYQYVYTRVNTRLERWAYRRARAITAVSQKVADEIRRIGIDGGRVGVIYNGVDAQAFANAAPDRRAFGLPAEPFMLLFVGDLRTPRKNLGTVLKALAHLPPNVHLAVAGYLPGSPYPDEARALKIDSRVHFLGLVKNMPTLMSSVDAYVFPSRYEAMSLSLLEAMAAGLPVVTARTAGGAEIITPECGIVLDDPDDPAALAAAIERLARSRDACRAMGEAARRLMEGFGWARMGAQYIALYRRLRQSSQPSPLAGTEHVVTQERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JD4</accession>
    <name>Q63JD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111788.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1784"/>
    <dbReference type="EnsemblBacteria" id="CAH39260">
        <property type="protein sequence ID" value="CAH39260"/>
        <property type="gene ID" value="BPSS1784"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1784"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6103"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CTQSIDE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="37000" checksum="F7AEAFF4B28C3CBA" modified="2004-10-25" version="1">MTADWPFAETMAAAAAASVASVAASADTVPPAARESRVRPRAAAWAGGEWIRADHPLPPAFGRFVKHLEYGLYVPSGAKTLGLPLVVMLHGCKQDMNQFSQGTRMNLLADRYGFAVLYPEQSLSAHAHGCWHWYEDTVHGGRGEAQAVVALVDALVAERGFDASRVYAAGMSAGAGLVSLLALHFPRRFAAVALHSGPAFGDAHSGITAMDVMRRGLHRDPAAVVDALVEPGAHPGMPAFIVHGDDDRVVVPKNADELAVQFLRLNGLADADGEPAGVERFETRAADVRTLDYRRDGESVVRLCRVHGLAHAWAGGDDSVPFHSAAGPDASELIWSFFASRERAAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JJ0</accession>
    <name>Q63JJ0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aconitate hydratase</fullName>
            <shortName evidence="12">Aconitase</shortName>
            <ecNumber evidence="12">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">citB</name>
        <name evidence="15" type="ordered locus">BPSS1726</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="12"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187807.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111732.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1726"/>
    <dbReference type="EnsemblBacteria" id="CAH39200">
        <property type="protein sequence ID" value="CAH39200"/>
        <property type="gene ID" value="BPSS1726"/>
    </dbReference>
    <dbReference type="GeneID" id="56598083"/>
    <dbReference type="KEGG" id="bps:BPSS1726"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5143"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="13">
        <location>
            <begin position="69"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="14">
        <location>
            <begin position="697"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH39200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="905" mass="98518" checksum="38AB18B8B764D046" modified="2004-10-25" version="1">MAHNLHKTLKEFDSGSGKGKFYSLPKLGKELKTKIERLPVSIRIVLESVLRNYDGKKITEEHIEQLANWKPNAKRVDEIPFVVSRVVLQDFTGVPLLADIAAMRGVAKRAGKNPKKIEPLVPVDLVVDHSVQIDYFRQKDALDLNMKLEFQRNNERYQFMKWGMQAFDTFKVVPPGVGIVHQVNLEYLARGVHKKKDDGDTVYYPDTLVGTDSHTTMINGIGVVGWGVGGIEAEAGMLGQPVYFLTPDVVGVELKGKLREGVTATDLVLTITEMLRKEKVVGKFVEFFGEGTKTLALPDRATIANMAPEYGATMGFFPVDEKTIDYFKGTGRTKAEIAAFENYFKAQELFGIPKAGEIDYTKTLTLDLSTVAPSLAGPKRPQDRIEIGNVKSTFTDLFSKPVAENGFAKKADDLTAEYRTSNGVAVKNGDVLIAAITSCTNTSNPSVLLAAGLLAKKAVEAGLTVAPHIKTSLAPGSRIVTEYLTKTGLLPYLAKLGFEVAAYGCTTCIGNAGDLTPELNEAITKNDIVAAAVLSGNRNFEARIHPNIRANFLASPPLVVAYAIAGNITKDLMTEPVGQGKGGRDVYLGDIWPSSDEVQALLKFALDPEKFEKNYSHLTKKGDLWSKIEGESGQVYDWPKSTYIAEPPFFGSDFSMEPAASIATVKGARALGIFGDSVTTDHISPAGSIKEDSPAGKWLKANGVQKADFNSYGSRRGNHDVMMRGTFANVRIKNLMIPAKADGTRVEGGLTIHQPSGEQLSIYDAAMKYIDADTPTVVFAGEEYGTGSSRDWAAKGTQLLGVKAVIARSFERIHRSNLVGMGVLPLQFKGSDSIQSLGITGDETYDIEGLGDDFKPQQDVTLVIHRKNGETKRVPVLLRIDTPIEVDYYKHGGILPFVLRSLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ9</accession>
    <name>Q63JQ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bglB</name>
        <name evidence="5" type="ordered locus">BPSS1657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528939.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111663.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1657"/>
    <dbReference type="EnsemblBacteria" id="CAH39131">
        <property type="protein sequence ID" value="CAH39131"/>
        <property type="gene ID" value="BPSS1657"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1657"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5053"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEPAYEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266927" evidence="3">
        <location>
            <begin position="22"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="655"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="731" mass="78460" checksum="2AD84D9F46DEB634" modified="2004-10-25" version="1">MHAKRLSIAVLSATLCALAHAAGNDAPSPDIASRDAYALRRAHALVRQMTLDEKLQLIHSKYPMSDVPGGGAGFIQGIARLGIPDLNMVDSATGSGSTSQPSTTFPATIGLAASWDKRLSYAFGAVIADQLRAQGFAMGLGGGTNLAREPRGGRLFEYLGEDPVLAGEMLAARTRGTQDRKVIATIKHYVGNEQETNRMGGDDQIDERTLRELYLLPFEIAMKAARPGNVMCSYNRLNGDYACENAHVLTDVLKNEWHFQGQVQSDWGAAHSTAKAINAGLDEEEDVGPTVFLTPALVKQALANREIAPARLDDMVRRKLYAMIRTGVMDDPPRGGGTIDFAAANRFVQYAAEQSIVLLKNQDRQLPLDAAGLKRIAVIGGHADAAVLAGGGSGNTRHPVTGAFPGCGGLTFPTTTGCNWWPNPWLKLDVPIVQAIRDLAPGATVAFAGNSDRQSPFAAYTPQQIDAAADLARRSDVAIVFVTQAAGEDFGELRSLALANPTNQDALVQAVAQANPRVIVVVESGNPVLMPWRDQVPAIVQAWFPGEGGGNAIANVLFGKVNPSGKLPVTFPARDEDTPTWGADGTLAPNPVYSEKLKIGYRWYDAHRIAPMFPFGHGLSYTHFSYSGLEVKQRPDAATTVSFALTNDGPVAGAEVPQVYLGDLDDPQEPPKRLVGWDKVGLRAGETRRVRIVIPAEMRRVWDASRNGWALAKGGRIYVGASSRDIRLQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JV4</accession>
    <name>Q63JV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530623.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111618.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1610"/>
    <dbReference type="EnsemblBacteria" id="CAH39085">
        <property type="protein sequence ID" value="CAH39085"/>
        <property type="gene ID" value="BPSS1610"/>
    </dbReference>
    <dbReference type="GeneID" id="56529978"/>
    <dbReference type="KEGG" id="bps:BPSS1610"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4996"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLYCRAK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="379"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="481" mass="52644" checksum="C7CEFD4A5A7E1792" modified="2004-10-25" version="1">MFSTLYFAAAAALANPSSNDAYAARVLDGRFAEAVALVAARCDSQPGDAAADVRDVHAYADIQLVLGRFEEAEDTFRRAQKLLRESRDQTRVMTCRNASWQAFFQNRFGVAQAGFRRIADDRAASAAQKLESLVGTCVVMHHLGRAEDAMATLDVLDAAARGDADGRWVRLAAALRADLLLQYQIGRADALGDHVYWRSALAELPPAAFAETGAPHAACAADAPPLLRMRVAYMRETRALAAGDHAALGRIDTHVSWCAKAGLADYQRSVRLEVALAALAGQAPNVADAMIAPYREAAGRCGSHARWTLDYLYCAAKVREQQGRIRESSSLYAHYALASVRHVRSDGAALAPALAIARCGTQAAAPSDDVSARLPGKYRRAYRYLMERLDQRELSVREIAAHIDVTERALQAAFKAYLGLSPSELIRRQRMERIRGELLSDAPRAASVLEIASRWGIQHRSTLVNGYRRMFDEAPSQTFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K54</accession>
    <name>Q63K54_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205632.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111518.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1511"/>
    <dbReference type="EnsemblBacteria" id="CAH38984">
        <property type="protein sequence ID" value="CAH38984"/>
        <property type="gene ID" value="BPSS1511"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1511"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4858"/>
    <dbReference type="eggNOG" id="COG3523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APTEDCD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="2">
        <location>
            <begin position="172"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1319" mass="142836" checksum="5B0B05AE4D8B1981" modified="2004-10-25" version="1">MMIARIAALLALAALSWASALYFDWPLWCAPAVFCAALAGWLLCRVARRALRAVRARAQLARLDASERLPAADAPELRVAARWRTALAALGRAQPAPRLRGRPRDALPWYLVIGPEGAGKTTALARARLVSPLRHARDDAAIAPTEDCDWWCFDDAVVLDLAGRFAAPGATDDDRRAWHALLEQLGRARARRGVNGVVVAIDAPRLIEASRDALTIEGSAIRERLEQLIRLFDRRFPVYVLVTQCDRLYGFDEWAAQLAPEQRERAFGYLGDHDADAFVARALDSLDARLGALRVALAARGEPPSPRALMLPHELACLRPALEAFARAAFGPNVYQETPYLRGLLFASGRQAGGAPSLTLPDWLDAAPARTPGDAGLFLHDLFARVLPGERDAWLPVERPSRSRLVLRRLALAAWLLASIAAGLLMSASFVGDMRTVELVRRDYPAHPRFTGEFAHDTATLERIGRVIADVERRDERRLVRPLAGATPVGRLEAELKRRYVAHYRRSIEPTADRLFFGEPDGASDVRAADDARLAARIRNLVRYVNLMQARRRGADRETLAQMPAPAVARATDGGGARGVDSVGVSGVSGVSGVSGGVGGVGGARAAEGAGRAVRASGGRRAGDARAARGMRGAAGNAGAGAEIAPAADGVRDRDEGFARVSALAVDLIAWSAPDDRALAARVAAAQAELERLAYRDPDGAWLLALPDASMPRDVTLADFWPAAEPRTLPDAQPAALRDVRVPAALTAAHRPAIDAFLDEMAQAVANRPKFAFHRDAFDTWYRARRIDAWRDFVARFPQGEQGLTTQAQWRAVIDRIADRRDPFSALLARVDREFESERDDTLPPWLRFVRTTSHMLAPAMLAPARLPAASGGLGAALGSISRSGGRALREALGGAPEQGRLTLERDAALRDALVDYERRVAALAADALAGPGAAYRLAADFHGFGVDPSVQASAMRAADSALRDVKRLAGDRDVGGDVVWSLVGGPLRALIAYVERQASCALQDDWERDVLWPLRRAATRDDVEGLLYGPQGAIWAFVDGPAKPFVRVGAARASALDTLGYRLPFTDAFLPLIDDAAARRVAQARRDAERRAQQQAALELDERIASLGKQIDALRAQTVRFGIVAQPTDVNPDAQAKPFETVLTLQCAPQARTLTNYNLRVSEQIDWQPDRCGDATLRISLGGVTLVRRYAGSLGVARFVQDFRYGVRRFTPRDFPDAKAQLQRLGVRHIDVRYDFSGHDALLAHVGRIDALERARRDDLARQRRAANRQDDDAGGATAIARAAASVANAPGAALPRRIGVCWGDPAHDRPDGDGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K98</accession>
    <name>Q63K98_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528763.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111474.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1468"/>
    <dbReference type="EnsemblBacteria" id="CAH38939">
        <property type="protein sequence ID" value="CAH38939"/>
        <property type="gene ID" value="BPSS1468"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1468"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4802"/>
    <dbReference type="eggNOG" id="COG5383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IPWTYAY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="DUF1338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1338" evidence="1">
        <location>
            <begin position="45"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="36537" checksum="734043645CB7F7CD" modified="2004-10-25" version="1">MNPNLAALLATVSDQPTIDELMRLMHVPTCFERCEPGVVTRAELAQALNMALFADLLERVPTGRAYTRDVARDGGRVTFDHGALRTVRWPSCGALPPGEAAFTRILRPLGYRLNGTYALERLKMTGRSYAHLDAPDQIAQFFVSELHPERFSAAFQAAVTNVLGTSADPLTPQAVATLAELERDASLPLADACALLPVLVRCFGRQHATPALADYDTLLAESAEMAWIATEGNAFNHATDRVPDVDALAAAQRALGRPIKPAVEVSRSGRVRQTAFRADPVARTFVDASGALVEREVPGSFYEFITRDAVADAQTGRRALDLSFDAGNATGIFKMTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE0</accession>
    <name>Q63KE0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194986.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111432.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1420"/>
    <dbReference type="EnsemblBacteria" id="CAH38895">
        <property type="protein sequence ID" value="CAH38895"/>
        <property type="gene ID" value="BPSS1420"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1420"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4744"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="34650" checksum="76649546480E7CEE" modified="2004-10-25" version="1">MKVLITGGAGFLGQRLAKQLLARGELTGPNGAPRRIDELVLLDVVQAHDFDDARVTARVGDIADRAVLEAAIDARTHAVFHLAAIVSGQAEADFDLGMRINLDASRLLLDVCRARGHRPRVVFTSSVAVYGGALPELVRDDTALEPQSSYGAQKAIAELLLSDYTRRGFVDGRVLRLPTISVRPGRPNAAASSFASGIVREPLNGEQAVCPVPGGTRLWLLSPRRAIDALIAGCELDGAALGNRRAINLPGLSVTVDDMIDALREVAGIEAVKLIRRAEDERVVKIVGSWPGRWDTSRAEALGLAGDASFVDVIRGYLEDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KF3</accession>
    <name>Q63KF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sctD</name>
        <name evidence="2" type="ordered locus">BPSS1407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556208.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111419.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1407"/>
    <dbReference type="EnsemblBacteria" id="CAH38882">
        <property type="protein sequence ID" value="CAH38882"/>
        <property type="gene ID" value="BPSS1407"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1407"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4731"/>
    <dbReference type="eggNOG" id="ENOG5032S5D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RSMWPRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="349" mass="36456" checksum="8B89875851E3E519" modified="2004-10-25" version="1">MKLLRILTGVHAGAQLQLAPGTHRIGSDDGADIRLTDWHAADLLLHVKDDVVRAQFVETDAERASSASDSSETVLLVDLAPMQFDSTVLCVGPDSSAWPSDFDLLSTLILRRAPQPLWRHRYARTATACIALGSVMLAVAAISTSQTSRAAPAPNVGYRAQRIVDALAAAHIDGLQARPIGDAVVVTGMVAHAADAATVRTLLASIASSGIVSRYDIAQQVSHNIEDSLGVPGAQVEYAGKGRFVVKGPPGRHEALEAAVARVRSDLDPNVTGVTVAAPESAAETAAENSASYAEMVAADGVQYAQTSDGVKHIYVADTPAQAGDNAPMRGNARSATRDVPPLPPNMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ8</accession>
    <name>Q63KQ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524243.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111313.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1304"/>
    <dbReference type="EnsemblBacteria" id="CAH38774">
        <property type="protein sequence ID" value="CAH38774"/>
        <property type="gene ID" value="BPSS1304"/>
    </dbReference>
    <dbReference type="GeneID" id="56530277"/>
    <dbReference type="KEGG" id="bps:BPSS1304"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4593"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RAWWVVS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="32068" checksum="D626F6C3D33A09E8" modified="2004-10-25" version="1">MNATVSSPPSAPASAGAPAAIRTPWSEFWRKFRKQRVALAAGAFVLLLVAVAIVGPHVVPYDPENYFDYDALNAGPSAAHWFGVDSLGRDIFSRIVAGARISLAAGFFSVALGAAIGTFFGLLAGYYEGWWDRATMRVADVLFAFPGILLAIGVVAILGNGMINVICAVAVFSVPAFARLVRGNTLALKQMTYVEAARSIGASDRTIIMRHILPGTVSSVVVYFTMRIGTSIITAASLSFLGLGAQPPTPEWGAMLNEARADMVNAPHVALFPSIAIFLTVLAFNLLGDGLRDALDPKLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KX4</accession>
    <name>Q63KX4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Family S11 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551740.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111247.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1239"/>
    <dbReference type="EnsemblBacteria" id="CAH38706">
        <property type="protein sequence ID" value="CAH38706"/>
        <property type="gene ID" value="BPSS1239"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1239"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4491"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LIYQHAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266123" evidence="9">
        <location>
            <begin position="40"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="50"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="333" mass="35441" checksum="07D7427B7AD52996" modified="2004-10-25" version="1">MTTEPLSTTVARGSRRAACALLRTPSRLFAALFVSAACAAPNGARAAPAPAPAIQAASWLVVDADSGKTLGAHNVDARREPASLTKLMTAYVAFDALERDALRWDDTVTVAADDIASVGRDEARMYLTPGQRVRVRDLMRGLIVASANDAALVLAKRIGGSPAGFATMMNDTARRLGMRDSHFVSPSGITTPDHYSTAHDLSILAQRLNRDFPAFYTFSSQRHFAYGAFAKTNKNRLLGADPSVDGMKTGHTNAAGWCMVVTAKRPVGGARARHRVIAVLLGEPTEKQRLADARALLDQGFASLGADAPAANAVQRANARPGEHRAQARARML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L00</accession>
    <name>Q63L00_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111221.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1213"/>
    <dbReference type="EnsemblBacteria" id="CAH38680">
        <property type="protein sequence ID" value="CAH38680"/>
        <property type="gene ID" value="BPSS1213"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1213"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5384"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YWYEHTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028244">
        <property type="entry name" value="T6SS_Rhs_Vgr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018769">
        <property type="entry name" value="VgrG2_C_DUF2345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10106">
        <property type="entry name" value="DUF2345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13296">
        <property type="entry name" value="T6SS_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="2">
        <location>
            <begin position="491"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS_Vgr" evidence="4">
        <location>
            <begin position="561"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2345" evidence="3">
        <location>
            <begin position="702"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="925" mass="99035" checksum="F5039D9544EE9616" modified="2004-10-25" version="1">MNDTLRNFASGAVDWNKRPVALHFGAAQAALGHLLALQHASVQEGLMTGIHGRLTRVSTRRDLPPGVLLGIPVSIRLITDRGQPHTVNAIISDVQIGQSDGELCVYQLTVCDALSLMDKRTNSRVFRKRSVIDVLATLFNEWQQRSPALARAFEFDLSGLRADRYPPRELTRQVNESDAHFVRRLLRREGITVFAKAGPAKGERPLQGDAPVHTLVCCDDPMSLPQAPAGTVRLHPRDGGAAQRDTVTLFALRRQLAPGKAGRPSWDYKKARIDESSVASSLDQGEAGNDLAKLLTDIAIDIAHAGDSWRDHERLTRARMLAHEFEAERHDGVSSVRDLAVGTWITLTGDPQWDRQRADKRQFVITSIDHDIWNNLPKGLNERVHALFAASRNLACAPRALPSALANDADTRYENTFACVRRGVPLAPAYDPQADLPPAHLLTGTIVGAEGEEVFCDEDGRVRVRVHGLDPADHAHAQGAGTNGNAGDSAPIRVASSLAGAYFGASFLPRVGMEVLLGCLGGDPDRLVIIGVLGNGAHPPATFSHAGGLPGNRYLSGIKTKEIRGQRYNQLRLDDTPNQISAQLASEHAHSQLNLGYLTQPRENGHGNDRGEGVELRTDAAAALRAAQGMLLTTYARTQASGGQLDRDELIRLLGECAELFKALGDYAGQHGGQAADTAGQYAVAAAFKRWAPGTGTDGADAPSDGAARALMAFGAQAGSVNVTPKTHVTYAGENIDQVAQQHLQLMSGQRLNATAGQGMQLFARGAGVQAVAGEGPMLLQAQAGTLTANAQKGVKITTNEHEVFVSAPKIRLVAEDGSYLELGGGITLGTNGDIKLLSASHQWGGPSTAQAAKSGFGNQPTDQRFKLHYPGEDGDLQAAANKRFRITLDDGRVIEGKTDASGLTDLVKDDAMRIAKIDYLKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L41</accession>
    <name>Q63L41_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004558034.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111180.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1167"/>
    <dbReference type="ESTHER" id="burps-q63l41">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38635">
        <property type="protein sequence ID" value="CAH38635"/>
        <property type="gene ID" value="BPSS1167"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1167"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4398"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KREVIAM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="294" mass="31024" checksum="226B8D618032A420" modified="2004-10-25" version="1">MTSIPVRLDRFAPAAAPADRADRADSAAATDGAPAAAFPATAAKAAIRTLVAPSPGGAHVLCIPWAGASIERFFAWKRHLPAGVGLSGVQLPGRGARAHEPSPTDLVALLDEIAAEYLALRDPPRILFGHSFGALIAFEIATRVSRAAGQAGGDPFVRLVVSGLSAPSVIAEEERIAHLDDDAFSAQVHALNGMPPEIARSPESLRYFMTVLRCDFRLYESYAFDANRPPLRCPIAVCSGRDDPSVSEHGLNAWAALTTGECRRHDFDGDHFFIADHAAAMLGLALDAESTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L50</accession>
    <name>Q63L50_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative respiratory nitrate reductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">narH</name>
        <name evidence="2" type="ordered locus">BPSS1158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205549.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111171.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1158"/>
    <dbReference type="EnsemblBacteria" id="CAH38626">
        <property type="protein sequence ID" value="CAH38626"/>
        <property type="gene ID" value="BPSS1158"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1158"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4383"/>
    <dbReference type="eggNOG" id="COG1140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VYFNWQT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10557">
        <property type="entry name" value="NarH_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="509" mass="57725" checksum="C5CDA40DE797DC3F" modified="2004-10-25" version="1">MKIRAQIAMVLNLDKCIGCHTCSVTCKNVWTSREGMEYAWFNNVETKPGIGYPKDWENQARWRGGWKRRADGRIEPLLGGKWRLLAQIFANPYLPEIDDYYEPFTFDYAHLQEAGDTKAMPVARPRSLVSGERLEKIEWGPNWEEILGGEFDKRSKDYNFEHVQKDIYGQFENTFMMYLPRLCEHCLNPACVAACPSGSIYKREEDGIVLIDQDKCRGWRMCVSGCPYKKIYYNWQSGKAEKCIFCYPRIEAGQPTVCSETCVGRIRYLGVLLYDADRIGEAASVERETDLYEAQLSLFLDPNDPAIAAHAERDGVPAAWLDAARRSPVYKMAIDWKIAFPLHPEYRTLPMVWYVPPLSPINAAANSGALGMNGYLPDVESLRIPLRYLANLLSAGDEAPVKRALERLLAMRAFMRARHVDRVDAPGVLKQAGLSVAQVDEMYRYLAIANYEDRFVIPTAHREYAEDAFDLRASCGFSFGNGCSGGTSETSLFGMKQGQRTIPIKEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L55</accession>
    <name>Q63L55_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004532950.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111166.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1153"/>
    <dbReference type="EnsemblBacteria" id="CAH38621">
        <property type="protein sequence ID" value="CAH38621"/>
        <property type="gene ID" value="BPSS1153"/>
    </dbReference>
    <dbReference type="GeneID" id="56530433"/>
    <dbReference type="KEGG" id="bps:BPSS1153"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4378"/>
    <dbReference type="OMA" id="GANWISE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="108" mass="11410" checksum="343BFBED9DB9B5EC" modified="2004-10-25" version="1">MIPCDVCRPLACERHPASVDVPLDALGKPTKLRPLLRKPVVIAKFRCRACGANWIREADASAPGEVHWLCLGDATSILEPVARGRKPADAAAAEARPAAPPAGAERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L57</accession>
    <name>Q63L57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative spermidine synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111164.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1151"/>
    <dbReference type="EnsemblBacteria" id="CAH38619">
        <property type="protein sequence ID" value="CAH38619"/>
        <property type="gene ID" value="BPSS1151"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1151"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5311"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIPEHLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="78"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="30709" checksum="999EEDADAA2A2244" modified="2004-10-25" version="1">MNERENQPMQPRFPGMPADASGPLRAPHRCARENSPVVIETPHLVSLCFDEHGMQSCMYVDGPDLLALGYTRTMAGFLLLHPRPRRIAMIGLGGGSLAKYCYRHLPDARITSIEINPDVIALRDRFRIPPDDARFTVLCADGARYVAEAGEACADVLIVDGFDAGGLPLALGTRQFYADCRRHLADGGVLAVNLLVDDPRVADCLAALRDAFGASAALAPAEDSALNLIVFAWKSDAPLPSLETMIERANALADRHSVDLGEAAVRIELGASYDWSRFGEPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L89</accession>
    <name>Q63L89_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RND efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111132.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1119"/>
    <dbReference type="EnsemblBacteria" id="CAH38587">
        <property type="protein sequence ID" value="CAH38587"/>
        <property type="gene ID" value="BPSS1119"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1119"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5272"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REYPKMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="970"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1018" mass="107754" checksum="8EC75431CBAA3F87" modified="2004-10-25" version="1">MFVRRPVLSLVFSLLILLVGLRALMSLPVRQYPALESATISVATDYPGASQELMQGFVTTPIAQSIATADGIEYITSTTTQGKSVVKARLRLNANADRAMTEVMAKVQQVKYKLPADAYDSVITKLTDAPTAVMYLGFASDALSIAQITDYVVRVAQPLVTTVPGVASAEILGGQNLAMRVWLDATRLAAHGLSAGDVAAAIRANNVQAAPGQVKGSLTIADISANTDLTDVGAFNEMVVKSAPNGGGLVRLKDVATVEIGGENYNSSALMNGRRAVYIAVNATPAGNPLEIVRGVGAVLPAMERNKPASVEIANMFDGARFVNASIAEVRSTLTEAIAIVVVVIFLFLGSFRAVIIPVLTIPLSLVGSAALMLAAGFSLNLLTLLAMVLAIGLVVDDAIVVVENIHRHIEQGEPPVRAALIGAREIASPVLVMMATLISVYAPIGLMGGLTGSLFKEFAFTLAGAVLVSGIVALTLSPMLGSLLLTSRMSEGRVAKAIERTLERVTHAYRRGLHASLAARPAILLIGAGVLAGIVLLFSGVKRELAPQEDQGSIMVAVKAPQYANLDYMERYAPDIERVFRTLPEADTSFILNSYGGSNLGFAGVNLVDWDKRTRSAAALQALIQARGDGIRGERVFAFQLPALPASSGGLPIQMVLRTPSGFADLYAQMERIKAAAQKSGLFAVLDSDLTFDSRAVGVTIDRNQANTLGVTMKDIADTLAVLVGENYVNRFNFKGRSYDVIPQVSRSERLSSEMLSRYYVKTGSGQMIPLSTVIQVTNGSQANALSQFNQMNAATFSAVPAPGVTMGDAVAFLEAQKLPAGFSIDWLGESRQYVQEGNRLAVTFGFALIVIFLVLAAQFESLRDPLVILVSVPLSICGALAPLYLGFATLNIYTQIGLVTLIGLISKHGILMVSFANDLQRHEGLDRRAAIERAAAVRLRPILMTTAAMVAGLVPLVFAAGAGAASRFAIGITVSTGMLVGTLFTLFVLPTVYTFVAKDHGAAMRSERAQLLAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LB4</accession>
    <name>Q63LB4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2760 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524145.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111107.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1094"/>
    <dbReference type="EnsemblBacteria" id="CAH38562">
        <property type="protein sequence ID" value="CAH38562"/>
        <property type="gene ID" value="BPSS1094"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1094"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4298"/>
    <dbReference type="eggNOG" id="ENOG5032SHU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RDARFID"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021212">
        <property type="entry name" value="DUF2760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10816">
        <property type="entry name" value="DUF2760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2760" evidence="1">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="191" mass="20145" checksum="6626DF9E13A78238" modified="2004-10-25" version="1">MTEPNISFAGRLSLAFGLFFSVLGDRELARRARRLRAGEAPAAPAAAPVAPPQPAAAPAPVVAQEATPDAALQLLGLLQRDARLIDFVEEDIAGYSDADIGAAARIVHDGCRATLREHFTIRPVRDEAEGTRVTIGEGFDAAAIRLTGNVVGQPPFHGSISHRGWRVDAVRLPKLNPGHDASIIAPAEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MC5</accession>
    <name>Q63MC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528006.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110746.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0735"/>
    <dbReference type="EnsemblBacteria" id="CAH38194">
        <property type="protein sequence ID" value="CAH38194"/>
        <property type="gene ID" value="BPSS0735"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0735"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6963"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WCLGTIQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016759">
        <property type="term" value="F:cellulose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003919">
        <property type="entry name" value="Cell_synth_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01439">
        <property type="entry name" value="CELLSNTHASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="3">
        <location>
            <begin position="539"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="655" mass="72470" checksum="0961DFD6680B7826" modified="2004-10-25" version="1">MFDFFLANRSLLDINGGVLLVVLLLTRAGRRERAADRIVFGGVTVVLLLVYLAWRATQTLPEPRMDFPSAWAHVFFGFECMALAYTLISVAVLTRTTERTPQADAGEAALRRAAAPPRVDIFIATYNEGLDILEKTIVAALAIDYPDFRVWVLDDTRRDWLKAFCDQVGARYATRADNAHAKAGNLNNGLRLSARSEGGGAPYIMVLDADFAPHRKILLRTVGLFADRTVGIVQTPQFYYNADPVQYNLRSAECWVDEQRAFFDVMQPAKDAWGAAFCIGTSFVVRRDLVERIGGFPTGTVTEDIHLTYRLMRHGYVTRWLNERLSVGLSAEGLPEYISQRSRWALGTIQVALTPDGPLRGRGYTFAQRLHYVHGMLHWLSRPFTLMLLLGPLLYWYFDIPTLYGEPLQFLAYGLPALIAYWGYSMWITGRRALPVFTEVTQIVCALAVSLSLASALVRPFGRPFKVTNKGLDRSKLIVHGRFAAFYAGLLVLSALGLGRALASAPGAPGLAFNAAWTAISLALYLASLLVCIELPRPRREERFPYRARARLRVGDREYAVATRDLSCNGAAVTTAQAASLPLHAAGALWLAPIGWIPCRIVRRDGALLGVALGADTAARHGLIRLLFGDPPHNIAIRGRPRLAISRLMQRALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MD5</accession>
    <name>Q63MD5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523805.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110736.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0723"/>
    <dbReference type="EnsemblBacteria" id="CAH38183">
        <property type="protein sequence ID" value="CAH38183"/>
        <property type="gene ID" value="BPSS0723"/>
    </dbReference>
    <dbReference type="GeneID" id="56530827"/>
    <dbReference type="KEGG" id="bps:BPSS0723"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6949"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CFWVVQP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="36895" checksum="83BDC969D11437F5" modified="2004-10-25" version="1">MVQNASVPPASAGRPKAQSIALGALYAALVALALWVIRDFMPAIAWACVVAIALWPALRRIDALPALRGRATLVAALLTSAVALLVVVPIAAGLVEAVDQSHELLGWLHRVEQTGIPEPDVLSHLPFGSQQASAWWQANLAKPLHPATAVKGVDGASVVTFGRHFGSRLAHAAVLFGFMLVTLFVIFQAGPRLSGSLLTGVRRAFGDSGAALLQRMAAAVYGTVTGLVVVGFGEGVLLGLAYAFAGLPHAALLGLVTAIAAMLPFCAPLVFGGAALWLFVQGALGWAIGLAAFGSVVVFAAEHFVRPVLIGNSARLPFLLVLFGILGGAETFGLLGLFVGPALMTVLTVLWAEWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ME5</accession>
    <name>Q63ME5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004548559.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110726.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0712"/>
    <dbReference type="DNASU" id="3096081"/>
    <dbReference type="EnsemblBacteria" id="CAH38172">
        <property type="protein sequence ID" value="CAH38172"/>
        <property type="gene ID" value="BPSS0712"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0712"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6933"/>
    <dbReference type="eggNOG" id="COG2343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DLVWAYP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="126" mass="13816" checksum="CBA93B16763E3A29" modified="2004-10-25" version="1">MTSSTHPVKMPGPDHPITIEATGARVVVKAGGHTIADTRDALTLREALYPAVQYVPRKDVDLARLERTTHESYCPYKGDASYYSIKGVGERGVNAVWSYETPHDAVEQIAGRLAFYPDRVDSITIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ6</accession>
    <name>Q63MJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110675.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38115">
        <property type="protein sequence ID" value="CAH38115"/>
        <property type="gene ID" value="BPSS0656"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0656"/>
    <dbReference type="eggNOG" id="ENOG502ZV58">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VMRMRNA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266164" evidence="2">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="125" mass="13572" checksum="3512A1966293C098" modified="2004-10-25" version="1">MGFTVAATIISMSNLGAAFAYDDLPKPPPPPEGWVQPPKPSEGTVTRDVENQIAQRFTAATGGNPNGLLSKQQAKAAGWGLVSDRFSDIDRAGTGYVRLDDVLRFMSKRTPQRVMRMRNATKPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MP6</accession>
    <name>Q63MP6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523193.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110625.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0604"/>
    <dbReference type="EnsemblBacteria" id="CAH38061">
        <property type="protein sequence ID" value="CAH38061"/>
        <property type="gene ID" value="BPSS0604"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0604"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6785"/>
    <dbReference type="eggNOG" id="ENOG5031CPF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APLWITR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021317">
        <property type="entry name" value="DUF2917"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11142">
        <property type="entry name" value="DUF2917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="14544" checksum="1D164B94793B795B" modified="2004-10-25" version="1">MDEASRLLFHPDPTRREGDDAIQLPRMTLHFALEPRAMMTWHARSHTEIRVLSARVWLTRSFSVDDYWLKPGDVLHVPRGERVWLSADGPAAAEVSLTTAYVRRRSWIGGMVDGLLDVAAELTGPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ0</accession>
    <name>Q63MQ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537297.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110621.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0600"/>
    <dbReference type="EnsemblBacteria" id="CAH38057">
        <property type="protein sequence ID" value="CAH38057"/>
        <property type="gene ID" value="BPSS0600"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0600"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4627"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="94" mass="10161" checksum="B3CB0138461A5C8C" modified="2004-10-25" version="1">MSPGPLNVRRFSPLSSHPAVFAVFAVFVPGAIAFAGAASASAKAAGRMLVGIRFTHRRLVDHRSVVKRRAASRLRERASGTYSHERMKDVSMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB2</accession>
    <name>Q63NB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS0384A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110407.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37835">
        <property type="protein sequence ID" value="CAH37835"/>
        <property type="gene ID" value="BPSS0384A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0384A"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6512"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="25777" checksum="45310AAA9363C654" modified="2004-10-25" version="1">MCMRRHLEEIREFLMLISRRVSAWLTGGVIAALLFVYEHASGNIPVSAVYLGVLVYTTLASYLAWRSERRARAGVEEAFERATRSAAQLQAARQERRRLSLHWSFVVADRLRGANLEEVEHPFVLSTADASGERFAEVWTLIRYAIKGANVIAPPPHDLNSMKLPAPKKPGIIIYGRNGFADAIATALSEVADVVRSTEYVDELNAYYATFGKNGVIGIAIGPGVPWKSTCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ND8</accession>
    <name>Q63ND8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199588.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110381.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0361"/>
    <dbReference type="EnsemblBacteria" id="CAH37809">
        <property type="protein sequence ID" value="CAH37809"/>
        <property type="gene ID" value="BPSS0361"/>
    </dbReference>
    <dbReference type="GeneID" id="56597211"/>
    <dbReference type="KEGG" id="bps:BPSS0361"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6484"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QWSVTIA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="136" mass="13908" checksum="905ACEEE78AE05F7" modified="2004-10-25" version="1">MRTKPVLTSDDVNKMAAAAEAFAAANQWAVTVAIFDDGAHLLHLHRMDGAAPSTVEMAIGKGRTAALGRRESKVYEDIVLQGRISFLSVPLVGLVEGGVPIVVDGETVGAIGVSGVKSEQDAAVARAGIAALTDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NI1</accession>
    <name>Q63NI1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523460.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110338.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37766">
        <property type="protein sequence ID" value="CAH37766"/>
        <property type="gene ID" value="BPSS0318"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0318"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4307"/>
    <dbReference type="eggNOG" id="ENOG503322B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRHLIDC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="31394" checksum="F4747A2CAF75C0D6" modified="2004-10-25" version="1">MISRPASGAGARAPRRPGRTGTDMKARPMLEYALHPLEDRLVHVDELCRADPVPRGWARCPLCLEALYVVQLRDRSHARRFAHLAGEFARCPLVNDALPNPLAVHVGPPLDEHGRQARATFFRHWQRHLHTIRQTASAFGIARFMRAIELADVLKLWAWPTLAQRDIPYILLVLTEFIAAPRGERKQAAWSRFWFDASVQRVDDLRKPRGVLPRLFRLRYRLPRMSKFPNARHLIDCQPVLMNDIGPSDAALGTPRADIAMFEAFAARFARRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NM0</accession>
    <name>Q63NM0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative rieske iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110299.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0279"/>
    <dbReference type="EnsemblBacteria" id="CAH37726">
        <property type="protein sequence ID" value="CAH37726"/>
        <property type="gene ID" value="BPSS0279"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0279"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6374"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VARDEYV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="33856" checksum="17D921008EE83849" modified="2004-10-25" version="1">MPVALSEQVSGRAALAVICMEQPLVLFRDASGAVCAMEDRCAHRRAPLSLGRVTPDGRLQCAYHGWTYDGATGACVAIPNLSASERVPAHYAAHAYKTLERDGFIWACARDAPPPAEAIPRAPRSARRFAGSVTVAIARDEYVAALADGPHLTMRIAGLYITDYVIADATPHDGDIATERGVTWLAHIVDRHFGVRYPWTLRVTSPRDGALASVELASRDGATALWASIAITPAARGATNVLWRGGVAADASGFGAKLFRTWARLHAAPFAMLAHVDGRALSTLDALYSRAWRGPIPEGIAHTRPMPADYRTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NW0</accession>
    <name>Q63NW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187753.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110209.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0188"/>
    <dbReference type="EnsemblBacteria" id="CAH37633">
        <property type="protein sequence ID" value="CAH37633"/>
        <property type="gene ID" value="BPSS0188"/>
    </dbReference>
    <dbReference type="GeneID" id="56596938"/>
    <dbReference type="KEGG" id="bps:BPSS0188"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6253"/>
    <dbReference type="eggNOG" id="COG2249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFPIHHG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="28929" checksum="318D7EA6B2673C3B" modified="2004-10-25" version="1">MNVLLVYAHPEPKSLNGSLKNFALRHLEEAGHAVQVSDLYAMQWKAALDADDNTARRPDTRFDPSLDSKHAFENGTQAADIAREQDKLRWADALVLQFPLWWFSMPAILKGWVERVYAFGFAYGVGEHSDTHWGDRYGEGSMKGKRAMLIVTTGGWASHYGPRGINGPIDDLLYPIHHGILYYPGFDVLPPFLVHRTNRIDETRFATIRDALGQRLDTLWTTAPIAFRAQNAGDYEIPQLTLRADIAPGRSGFAAHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ7</accession>
    <name>Q63NZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110172.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0151"/>
    <dbReference type="EnsemblBacteria" id="CAH37596">
        <property type="protein sequence ID" value="CAH37596"/>
        <property type="gene ID" value="BPSS0151"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0151"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4083"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WYMSLQH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="388" mass="43838" checksum="8CA122D5AF673EC5" modified="2004-10-25" version="1">MRIHWLVGPPRLVTVHAWPCVPRKAQSSSVCLSTFGFHPHRNMAEYFDVDHAREIAALGERFAARTEWPTWLLIFVVYGGWLGVLLGVRAGQLPLAAATPLLIALCAWHMSLQHELLHGHPTRSARVNKLLGYPPLAVWYPYTLYRDTHLEHHRDEDLTAPGIDPESNYVPLAQWTRLPRWRRALWRARKCFVGRLVVGPPESVAAMGAATLRAWHGGDWRDAPMWAAHAVSVVALLAWLHGSIGVPWWYYLLAITWPAQSLAMIRSLYEHRAAEHPKARIAINEAGLAMRMLYLNNNYHLVHHDLPKLPWYQLPRAYRLRRDAYARKCGGFVIRGGYWELLKRHAWRVTDSPVHPFAGRGASDRASGGGATPGARVAVIEDCVQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P47</accession>
    <name>Q63P47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551170.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110122.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0099"/>
    <dbReference type="EnsemblBacteria" id="CAH37545">
        <property type="protein sequence ID" value="CAH37545"/>
        <property type="gene ID" value="BPSS0099"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0099"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6128"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LSWSWNV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17425" checksum="14B389B84380EE8F" modified="2004-10-25" version="1">MSHDIFLKINGIDGEAEDATHKGEIEVLSWSWNVSQQSNMHLGSGGGAGKATIDDLQFEHYIDRASPNLVQYCLLGKHIDEARLVVRKAGGSPLEYIKLTMSDVLVTQVSPTGVAQDESRPRELVRLSFSRLKQEYVVQNPQGGSGGAITATFDIKKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P66</accession>
    <name>Q63P66_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110103.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0080"/>
    <dbReference type="EnsemblBacteria" id="CAH37525">
        <property type="protein sequence ID" value="CAH37525"/>
        <property type="gene ID" value="BPSS0080"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0080"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3997"/>
    <dbReference type="eggNOG" id="ENOG502Z9TZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYDAQER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021531">
        <property type="entry name" value="DUF2875"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11394">
        <property type="entry name" value="DUF2875"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="451" mass="50081" checksum="F913A8553B3C9231" modified="2004-10-25" version="1">MLAQSGGKFVLEVRGLGLVAGKETNEEIWKAVEAKADNHSTYMSQNPADYPANEDERMTEVELSTRISFKYGARHSVEYWPVPVFIWEPPKAQRADRPGAELSGLRQEASLGVTLLLWQEDANTDDGTSIVEKLFAFFDAHPDVPEAVIVTFDGAATRKLNQTPGYVDTFKQSNIPSMPDSMVSMLVSRSDRVDRLIRPYAVEQTEDVNKNTTDYDVTRLWNYFWKINHDSGPDGFSAHYDAQERKAGVDTPMSPGFVTSAWWQTKLPAFWKTISNKGPGEFKPMPYIPVRWTTWQVKQFDNAPLLGYLHRPIDVKLADAHGKPLKTAQQVQALKAGWQQAVDTLPTGETPKRIFYDTTGDRAWVAPINQALAQSGPSAPSLDDVKEGYDIGRRIGNTGISSPLVQIGLGLIASYHEGGASATIHRRPNGTATIVMVSPPTHKQPDVNPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PC3</accession>
    <name>Q63PC3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR-like family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529569.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110046.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0022"/>
    <dbReference type="EnsemblBacteria" id="CAH37465">
        <property type="protein sequence ID" value="CAH37465"/>
        <property type="gene ID" value="BPSS0022"/>
    </dbReference>
    <dbReference type="GeneID" id="56531532"/>
    <dbReference type="KEGG" id="bps:BPSS0022"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6021"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PPEIHEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="25836" checksum="934FA8746A35FE36" modified="2004-10-25" version="1">MRHAHRFSRRECGMSDSFGHSPFEMFRQMFGGHRRGGGRHGFGPFGGFGGGPGGFGGFGDDAMPRGRQFSADDLQLLLLALLAEQPSHGYELIKALDTRSSGFYAPSPGMVYPALTYLEELGYVTVQAEGNRKRYALADAGRAHLDAQRERVEMLFAKLAHLGRKMEFMRRAFAGEAPAAPEDDTRGWLPEFVEARMALKQALFRRSGANADEQRRIAAILRRAVADIEGRAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PF3</accession>
    <name>Q63PF3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110016.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3423"/>
    <dbReference type="EnsemblBacteria" id="CAH37435">
        <property type="protein sequence ID" value="CAH37435"/>
        <property type="gene ID" value="BPSL3423"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3423"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3893"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLIFQQW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="183" mass="20244" checksum="E5BD90FAFBD796FE" modified="2004-10-25" version="1">MCMDKCDNCASKRIITRRIIMLELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIDGYRVVLRPERLGLGVTAFTSLKLKHHGDSIIEQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSSFVMKKLMRVPGVDSVRSNIVLTTFKRNGPLPLGHLASGAPAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI0</accession>
    <name>ATPB1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta 1</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD1</name>
        <name type="ordered locus">BPSL3396</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185243.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109989.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PI0"/>
    <dbReference type="SMR" id="Q63PI0"/>
    <dbReference type="STRING" id="272560.BPSL3396"/>
    <dbReference type="PRIDE" id="Q63PI0"/>
    <dbReference type="EnsemblBacteria" id="CAH37408">
        <property type="protein sequence ID" value="CAH37408"/>
        <property type="gene ID" value="BPSL3396"/>
    </dbReference>
    <dbReference type="GeneID" id="56593896"/>
    <dbReference type="GeneID" id="66545412"/>
    <dbReference type="KEGG" id="bps:BPSL3396"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3864"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000254232" description="ATP synthase subunit beta 1">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="464" mass="50623" checksum="BCDC614B33CF456F" modified="2004-10-25" version="1">MSTAALVEGKIVQCIGAVIDVEFPRESMPKIYDALILEGSELTLEVQQQLGDGVVRTICLGASDGLRRGVVVKNTGNPISVPVGKPTLGRIMDVLGRPIDEAGPIESENKRSIHQKAPAFDELSPSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELINNIAKEHGGYSVFAGVGERTREGNDFYHEMKDSNVLDKVALVYGQMNEPPGNRLRVALTGLTMAEHFRDEGLDVLFFVDNIYRFTLAGTEVSALLGRMPSAVGYQPTLAEEMGKLQERITSTKKGSITSVQAVYVPADDLTDPSPATTFGHLDATVVLSRDIASLGIYPAVDPLDSTSRQIDPNVIGEEHYSITRRVQQTLQRYKELRDIIAILGMDELSPEDKLSVARARKIQRFLSQPFHVAEVFTGSPGKYVPLKETIRGFKMIVDGECDHLPEQAFYMVGTIDEAFEKAKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI7</accession>
    <name>Q63PI7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BPSL3389A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202912.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109982.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37401">
        <property type="protein sequence ID" value="CAH37401"/>
        <property type="gene ID" value="BPSL3389A"/>
    </dbReference>
    <dbReference type="GeneID" id="62648107"/>
    <dbReference type="KEGG" id="bps:BPSL3389A"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1803"/>
    <dbReference type="OMA" id="GYAHGAK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="56" mass="6177" checksum="72F5A812C95EEF9B" modified="2004-10-25" version="1">MDGWVVIGIVLAAWIAGAIVFVHRASAVFFQALGCAQRVKKDERRARLSGLREAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PL5</accession>
    <name>Q63PL5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195883.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109954.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3359"/>
    <dbReference type="EnsemblBacteria" id="CAH37372">
        <property type="protein sequence ID" value="CAH37372"/>
        <property type="gene ID" value="BPSL3359"/>
    </dbReference>
    <dbReference type="GeneID" id="56594514"/>
    <dbReference type="KEGG" id="bps:BPSL3359"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1842"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPYRADG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266656" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="119" mass="12816" checksum="10CD7D9797573B1C" modified="2004-10-25" version="1">MQRLIRAAACCVLVSSLAACVVTPPRPAPAPAPRPSPQVVGYERMQQIQGRIDNLSHRIDARVNAGYYPPPQGAALHRRLDVIRQESTDMAAQHGGGLSGDEQRVLNQELDVAARAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PR0</accession>
    <name>Q63PR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HNS-like transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like protein H-NS family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198201.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109909.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3313"/>
    <dbReference type="EnsemblBacteria" id="CAH37326">
        <property type="protein sequence ID" value="CAH37326"/>
        <property type="gene ID" value="BPSL3313"/>
    </dbReference>
    <dbReference type="GeneID" id="56593981"/>
    <dbReference type="KEGG" id="bps:BPSL3313"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1903"/>
    <dbReference type="eggNOG" id="COG2916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KWIVGKN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027444">
        <property type="entry name" value="H-NS_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001801">
        <property type="entry name" value="Histone_HNS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00816">
        <property type="entry name" value="Histone_HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00528">
        <property type="entry name" value="HNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNS" evidence="6">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="98" mass="10967" checksum="A8C39E78FC0789C1" modified="2004-10-25" version="1">MSQYAKIKAQIVELQAQAEEVRRQEIAAVVAELQGKIAEYGLTAQDLGFAERARRGRPPKKGPLPAKYRDPKSGNTWSGRGKPPHWIVGKNRERFLIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q07</accession>
    <name>RS7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">BPSL3217</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198359.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109811.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q07"/>
    <dbReference type="SMR" id="Q63Q07"/>
    <dbReference type="STRING" id="272560.BPSL3217"/>
    <dbReference type="EnsemblBacteria" id="CAH37228">
        <property type="protein sequence ID" value="CAH37228"/>
        <property type="gene ID" value="BPSL3217"/>
    </dbReference>
    <dbReference type="GeneID" id="46324796"/>
    <dbReference type="GeneID" id="60548043"/>
    <dbReference type="GeneID" id="61020263"/>
    <dbReference type="GeneID" id="66525172"/>
    <dbReference type="KEGG" id="bps:BPSL3217"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2021"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="PRO" id="PR:Q63Q07"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000124237" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17686" checksum="982B1D37CBBBF1B3" modified="2004-10-25" version="1">MPRRREVPKREVLPDPKYGNVDVAKFMNMLMLSGKKSVAERIVYGAFEQIQTKGGKDPLEVFTVALNNVKPVVEVKSRRVGGANYQVPVEVRPSRRMALAMRWLREAAKKRSEKSMALRLAGELSEAAEGRGGAMKKRDEVHRMAEANRAFSHFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q59</accession>
    <name>Q63Q59_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551000.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109759.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3166"/>
    <dbReference type="EnsemblBacteria" id="CAH37176">
        <property type="protein sequence ID" value="CAH37176"/>
        <property type="gene ID" value="BPSL3166"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3166"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2073"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESFSAWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266526" evidence="4">
        <location>
            <begin position="24"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="441" mass="48018" checksum="A3DE06254BFFD613" modified="2004-10-25" version="1">MKYKMLVRSLAFGGVLWFGAQQAACAATEIQFWHAMEAALGERVNEIAAQFNASQSDYKIVPVFKGTYDQALAAGIAAYRSGNAPAILQVYEVGTATMMQAKKAVLPVSDVFRQAGVPLDEKAFVPTIASYYSDARTGRLVSMPFNSSTPVLYYNKDAFRKAGLDPNQPPKTWADVKADAEKLKKAGYACGYTTGWQGWIQLENYSAWHGLPFATRNNGFDGADATLEFNKPQQIAHIQFLQDMAKDGTFTYVGRKDEASAKFYSGDCAIMTTSSGALATIHKYAKFDFGTGMMPYDAGVKGAPQNAIIGGASLWVLAGKDPATYKGVAKFLAYLSSPAVAAKWHEDTGYLPVTTAAYDLAREQGFYAKHPGADTAIKQMMNKPPLPYTKGLRLGNMPQIRTIVDEELEQVWAQKKTPKAALDSAAARGDELLRRFEKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q69</accession>
    <name>Q63Q69_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109749.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3156"/>
    <dbReference type="EnsemblBacteria" id="CAH37166">
        <property type="protein sequence ID" value="CAH37166"/>
        <property type="gene ID" value="BPSL3156"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3156"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3607"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HADGFGW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="184" mass="19482" checksum="F04FF80C0FAF6045" modified="2004-10-25" version="1">MAGDRLRCFVALTLDRASRDALAALPVAAGARRTPRDQLHVTIAFLGAIERAKSELLGARIPALAAAGAVPPVDVERVVCWPSTAHARLVVAELAPQPSLLALGERVGGALRALGLPPDSRAFKPHVTIARFPRDAHRVTIDGACGAERRTPLALRFETLTLYESVLTRMGAEHRVLAAAALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QE1</accession>
    <name>Q63QE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL3082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521974.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109677.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3082"/>
    <dbReference type="EnsemblBacteria" id="CAH37093">
        <property type="protein sequence ID" value="CAH37093"/>
        <property type="gene ID" value="BPSL3082"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3082"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2169"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YGMTEVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="427" mass="45039" checksum="B45EEC22EEF76964" modified="2004-10-25" version="1">MNWAARRIGGRFHYGWLAAAVVFLILLAAAGTRATPSVLMVPLEHEFGWSRASISLAISVNIALYGLTGPFAAAAMQRFGVRPTVLAALGVMGMGVALSSMMTATWQMVLVWGVMVGGATGVAALTLSATFVTRWFVARRGLVMGLLTASSATGQLVFLPMLAAIAQRHGWRPVVLTVAVAAAIAVPLVALLLPERPSDVGLRPYGEPANAPRAEDGAKRNPIAVAFGMLATASKTRDFWLLFFSFFICGASTNGYVGTHLIAMCSDYGMTQVQGASLLAAMGVFDLIGTTMSGWLSDRYDSRVLLFWYYGLRGLSLIYLPHAFGIDFFGLPLFAVFYGLDWIATVPPTVRLATDVYGKDAAPVVFGWIVAGHQLGAAFAALGAGMLRASLGTYTVASMISGGLCIVGALIVLRINRGTARVSASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QF2</accession>
    <name>Q63QF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198580.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109666.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3071"/>
    <dbReference type="EnsemblBacteria" id="CAH37082">
        <property type="protein sequence ID" value="CAH37082"/>
        <property type="gene ID" value="BPSL3071"/>
    </dbReference>
    <dbReference type="GeneID" id="56597066"/>
    <dbReference type="KEGG" id="bps:BPSL3071"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2186"/>
    <dbReference type="eggNOG" id="ENOG5031HR3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WWLHPLR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="84" mass="8627" checksum="FE1FD2037E0D78AB" modified="2004-10-25" version="1">MNWFGIVVLGFAVGLLGWALNPLRRLSRASLWLAAAAGVLGAAAAKMAGNVAGLFYDGETLEWPVCTAAALLAVAVTVGLSARR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QJ8</accession>
    <name>MURC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murC</name>
        <name type="ordered locus">BPSL3024</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522018.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109620.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QJ8"/>
    <dbReference type="SMR" id="Q63QJ8"/>
    <dbReference type="STRING" id="272560.BPSL3024"/>
    <dbReference type="EnsemblBacteria" id="CAH37036">
        <property type="protein sequence ID" value="CAH37036"/>
        <property type="gene ID" value="BPSL3024"/>
    </dbReference>
    <dbReference type="GeneID" id="56528170"/>
    <dbReference type="KEGG" id="bps:BPSL3024"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2242"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182072" description="UDP-N-acetylmuramate--L-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <sequence length="465" mass="49026" checksum="B1370A551C6E3E83" modified="2004-10-25" version="1">MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYQVSGSDLARNAVTERLEALGARVSIGHDAANIEGANAVVVSTAVRSDNPEVLAARRLRVPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLTSAGANARLGTGDFIVAEADESDASFLNLYPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCIDDANVRQIVPLISKPVVRYGFAADAQVRAENVEARDGRMHFTVRREGREPLPVVLNLPGLHNVQNALAAIAIATDLDVADAAIQQALAEFNGVGRRFQRYGEIAAAGGGAYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLAFQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAPISTANGDALSRALRAAGKVEPVFVATVDEVPDALAKLARDGDVVITMGAGSIGGVPGKLAQDTQQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QK1</accession>
    <name>Q63QK1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">BPSL3021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545961.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109617.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3021"/>
    <dbReference type="EnsemblBacteria" id="CAH37033">
        <property type="protein sequence ID" value="CAH37033"/>
        <property type="gene ID" value="BPSL3021"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3021"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2245"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="43803" checksum="8DE6A60E67404FEF" modified="2004-10-25" version="1">MSKDYKDLLVALDIGTSKVVAVVAELKGESHYEVIGLGQSESKGLKKGVVVNIEATVQSIQRALEEAELMADCKITNVFTGIAGSHIRSFNSSGMVAIKEKEVTQTDVARVIETAKAINIPTDQQVLHILTQEFIIDGQEDVREPIGMSGIRLEVKVHIVTGAVSAAQNIVKCVRRCGLEVNDLILQPLASSLAVLTEDEKDLGVVLVDIGGGTTDIAIFAEGAIRHTAVIPIAGDQITSDIAMALRTPTPDAEDIKVGYGIAKQALADPDEMVEVPGLGERGPRTLSRQALAAVIEPRVEELFSLVQQVVRESGYEELLSSGVVLTGGAAMMPGMVELGEDIFLKPVRIGAPEYAGGLSDVVRNPRYSTAMGLLVEGSAQRMRGRKVAVQSGSAGQIFSRMKEWFLSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QQ0</accession>
    <name>Q63QQ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194232.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109568.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2974"/>
    <dbReference type="ESTHER" id="burma-q62gy2">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36984">
        <property type="protein sequence ID" value="CAH36984"/>
        <property type="gene ID" value="BPSL2974"/>
    </dbReference>
    <dbReference type="GeneID" id="56594223"/>
    <dbReference type="KEGG" id="bps:BPSL2974"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2301"/>
    <dbReference type="eggNOG" id="COG2939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QTIRYTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266529" evidence="2">
        <location>
            <begin position="21"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="544" mass="57610" checksum="25064BB56C3B1DDF" modified="2004-10-25" version="1">MPARKAQLLLAAVFSSLLIAACNGDDAGSPASAAASENSSGNIDASSGADKPYRDPNRYSSSGSASLSPSAVTENAAITHHQITVNGKTINYTATAGHLSARNPQSGAAEASFFYVAYTADNQPLGKRPVTFFYNGGPGSSTVWLHLGSFGPKRLVTGDPNANSPTPFPFVDNQETLLDTTDLVFVDAIGTGFSEAIAPNTNQTFWGVDQDAGAFRDFVIRYLQVNQRNDSPKYLFGESYGTPRTDVLANLLETAGVKLDGIVLQSSILNYNSNCDMASNSVGGSNSGSSAVSCAGFVPSYGAIGAYYQLDNPNPTNLPQYADQMRLLTAGTYSPAVDAYLANHTPPSSSLVTTMSNATGATVPLWRANFNLLPTSYDNSYQLALIPGTLIGRYDARVNVPTNSPLASDGDPSSSFITKPFTDTIGTYLPNVLKYTAKSAYAVQSNAIASWDWSHDGLDLPDTIPDLAAALTLNPALKVLSLNGYHDIATPFYQTELDLARLGAQPNLTIKDYQGGHMVYLDDTSRPQEKADLATFYAAAPAAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QX0</accession>
    <name>SYY_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">BPSL2904</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533566.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109498.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QX0"/>
    <dbReference type="SMR" id="Q63QX0"/>
    <dbReference type="STRING" id="272560.BPSL2904"/>
    <dbReference type="EnsemblBacteria" id="CAH36914">
        <property type="protein sequence ID" value="CAH36914"/>
        <property type="gene ID" value="BPSL2904"/>
    </dbReference>
    <dbReference type="GeneID" id="56528293"/>
    <dbReference type="KEGG" id="bps:BPSL2904"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2385"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000236701" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="243"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <sequence length="413" mass="45718" checksum="FD8D80167B3DB141" modified="2004-10-25" version="1">MSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATDKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDGVEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGGRNPRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QZ7</accession>
    <name>Q63QZ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative paraquat-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194239.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109471.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2877"/>
    <dbReference type="EnsemblBacteria" id="CAH36887">
        <property type="protein sequence ID" value="CAH36887"/>
        <property type="gene ID" value="BPSL2877"/>
    </dbReference>
    <dbReference type="GeneID" id="56593708"/>
    <dbReference type="KEGG" id="bps:BPSL2877"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2418"/>
    <dbReference type="eggNOG" id="COG2995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGMLEVY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007498">
        <property type="entry name" value="PqiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="23616" checksum="C5892867BE1C9462" modified="2004-10-25" version="1">MDRNALIACHECDALLHKPRLSGKDTARCPRCDALLYRSGSAQIDRICALTTGALITFLIAQGFPILEMDVNGMRVQTTLFGALEAMWNQGMPLVAVMVFCSTLLFPLVEMSALLYVLFPLRSGAIAPGFNGVLRAIQLVRPWGMIEVFMLGILVTIVKMVSLARVVPEAALFAFAALTLMLAVVVMFDPRTLWDIADSLRERAAGAAPGSADESSAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R42</accession>
    <name>HRCA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hrcA</name>
        <name type="ordered locus">BPSL2832</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194248.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109426.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63R42"/>
    <dbReference type="SMR" id="Q63R42"/>
    <dbReference type="STRING" id="272560.BPSL2832"/>
    <dbReference type="EnsemblBacteria" id="CAH36842">
        <property type="protein sequence ID" value="CAH36842"/>
        <property type="gene ID" value="BPSL2832"/>
    </dbReference>
    <dbReference type="GeneID" id="56594679"/>
    <dbReference type="KEGG" id="bps:BPSL2832"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2470"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000182461" description="Heat-inducible transcription repressor HrcA">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <sequence length="340" mass="37426" checksum="921822802870379C" modified="2004-10-25" version="1">MLDPRARTLLKTLIERYIADGQPVGSRTLSRYSGLELSPATIRNVMSDLEELGLVSSPHTSAGRVPTPRGYRLFVDTMLTVESPIDSDAVTRLVQTTLQAGEPQQRVVAAAASVLSNLSQFAGVVLTPRRSHVFKQIEFLRLSDKRILLIIVTPEGDVQNRMIATQRDYAPAQLTEASNYINAHFAGLSFDEVRRRLREEIDQLRGDMTALMHAAVTASTEEPDDEETVLISGERNLLEVADLSSDMARLRKLFDVFDQKTSLLQLLDVSSHAQGVQIFIGGESTLVPIDEMSVVTAPYEVNGKIVGTLGVIGPTRMAYNRVIPIVDITARLLSLTLSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC6</accession>
    <name>Q63RC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109342.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2746"/>
    <dbReference type="EnsemblBacteria" id="CAH36754">
        <property type="protein sequence ID" value="CAH36754"/>
        <property type="gene ID" value="BPSL2746"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2746"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3136"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EDRHFVT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="91"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="29466" checksum="6DAA333B036B9C68" modified="2004-10-25" version="1">MFCKLSPVYHRMNFSTIDADTLDERKFVVALARGLDLLRAFRPGETMLGNRDFAERTGLPKATVNRLAYTLTVLGYLRYDDALGKYALDAGVLSLGYALLAGSDTLALARPHMQALAREIGAAVSLGCRDGLDMIYLETIRSETALTLGLASGSRLSMLTSSMGRAYLAVQPPDARAALFAELRKTVGKGRAGAALVDAARRAADAFAADGCCYSFGDWHGDVNAAAVPFREPREGRWLILSCSGPASSMGEDVFRNRIGPKLKVLARRLGEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RG2</accession>
    <name>Q63RG2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546282.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109306.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2710"/>
    <dbReference type="EnsemblBacteria" id="CAH36718">
        <property type="protein sequence ID" value="CAH36718"/>
        <property type="gene ID" value="BPSL2710"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2710"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2622"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRSAGWT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="175" mass="18860" checksum="E661C6318AA9D233" modified="2004-10-25" version="1">MSHAIGVRRIGPDEAAACVDALSDVLIDCVEGGASVNFMAPLARDKARAFWREAAEGVARGERTLFVAEDADGRIVGTVQMITRQPENQPHRADVAKMLVHRDARRRGVAQRLLAALDDAARAAGKTVLVLDTVTGGDAERLYARAGWQRVGVVPDYALMPDGAPCATTFFYKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S26</accession>
    <name>Q63S26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-responsive regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lrp</name>
        <name evidence="5" type="ordered locus">BPSL2496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522368.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109091.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2496"/>
    <dbReference type="EnsemblBacteria" id="CAH36502">
        <property type="protein sequence ID" value="CAH36502"/>
        <property type="gene ID" value="BPSL2496"/>
    </dbReference>
    <dbReference type="GeneID" id="56528685"/>
    <dbReference type="GeneID" id="66547906"/>
    <dbReference type="KEGG" id="bps:BPSL2496"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2886"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="18662" checksum="0EBD6B8A3F352FF5" modified="2004-10-25" version="1">MRTQRQPVRALDKLDRRILKLLQEDGRMAMKDLAERVGLTVTPCIERVRRMERDGVITGYHARVDPSQLGASLLVFVEITLDHKNGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLMIAVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S36</accession>
    <name>Q63S36_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109081.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2486"/>
    <dbReference type="EnsemblBacteria" id="CAH36492">
        <property type="protein sequence ID" value="CAH36492"/>
        <property type="gene ID" value="BPSL2486"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2486"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2898"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYIWGAT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="227" mass="25236" checksum="AA28D51B2AD72032" modified="2004-10-25" version="1">MIRRPIIDPEVLPIETTGADLPVVRPSSMTPDGLRERFAEPPEWTQEPAEAQLAHGVDPRSAAVLVPLVVRERGLTVLLTQRADHLNDHAGQISFPGGRREPDDRDANATALREAREEIALAHERVELLGALPDYLTGTGFCVTPVVGLVHPPFTVQPDTLEVAEIFEVPLDFLMNPAHHQIRVLRWEGGERRFFAMPYPRGPVGGQYFIWGATAGMLRNLYRFLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S89</accession>
    <name>Q63S89_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpoE</name>
        <name evidence="5" type="ordered locus">BPSL2436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193971.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109028.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2436"/>
    <dbReference type="EnsemblBacteria" id="CAH36439">
        <property type="protein sequence ID" value="CAH36439"/>
        <property type="gene ID" value="BPSL2436"/>
    </dbReference>
    <dbReference type="GeneID" id="56596351"/>
    <dbReference type="KEGG" id="bps:BPSL2436"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2954"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LVDMQGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014286">
        <property type="entry name" value="RNA_pol_sigma70_RpoE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02939">
        <property type="entry name" value="RpoE_Sigma70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="22594" checksum="451B682273F8F7D7" modified="2004-10-25" version="1">MSEKEIDQVLVERVQNGDKAAFELLVSKYHRKIIRLISRLVRDPAEVEDVAQDAFIKAYRALPQFRGESAFYTWLYRIAVNTAKNYLATQGRRAPTSTDADAEEAETFSDADQLRDINTPESMLMSKQIAQTVNAAMALLPEELRTAITLREIEGLSYEEIAEMMGCPIGTVRSRIFRAREAIAAKLRPLLDTPEGRRW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SH6</accession>
    <name>HUTH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
            <shortName evidence="1">Histidase</shortName>
            <ecNumber evidence="1">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutH</name>
        <name type="ordered locus">BPSL2344</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527399.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108940.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SH6"/>
    <dbReference type="SMR" id="Q63SH6"/>
    <dbReference type="STRING" id="272560.BPSL2344"/>
    <dbReference type="EnsemblBacteria" id="CAH36347">
        <property type="protein sequence ID" value="CAH36347"/>
        <property type="gene ID" value="BPSL2344"/>
    </dbReference>
    <dbReference type="GeneID" id="56528843"/>
    <dbReference type="KEGG" id="bps:BPSL2344"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3075"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000160998" description="Histidine ammonia-lyase">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="1">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <sequence length="507" mass="53111" checksum="77AFFE21CBAC651E" modified="2004-10-25" version="1">MITLTPGRLTLPQLRRIARENVQIALDPASFAAIDRGAQAVADIAAKGEPAYGINTGFGRLASTHIPHDQLELLQKNLVLSHAVGVGEPMARPVVRLLMALKLSSLGRGHSGIRRVVMDALVTLFNADVLPLIPVKGSVGASGDLAPLAHMSAVLLGIGDVFIRGERASAAEGLRVAGLAPLTLEAKEGLALLNGTQASTALALDNLFAIEDLYRTALVSGALSVDAAAGSVKPFDARIHELRGHRGQIDAAAAYRSLLDGSAINVSHRDCDKVQDPYSLRCQPQVMGACLDQIRHAAGVLLIEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLIDATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATFAARKLADIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHYFAPDIAVVARRVRERAFATLSPLSFESEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SP8</accession>
    <name>PYRG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">BPSL2272</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192790.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108868.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SP8"/>
    <dbReference type="SMR" id="Q63SP8"/>
    <dbReference type="STRING" id="272560.BPSL2272"/>
    <dbReference type="PRIDE" id="Q63SP8"/>
    <dbReference type="EnsemblBacteria" id="CAH36275">
        <property type="protein sequence ID" value="CAH36275"/>
        <property type="gene ID" value="BPSL2272"/>
    </dbReference>
    <dbReference type="GeneID" id="56596066"/>
    <dbReference type="KEGG" id="bps:BPSL2272"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3158"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000266083" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="295"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="1">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <sequence length="553" mass="61042" checksum="A1EF2D0573BB39DD" modified="2004-10-25" version="1">MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRPIPDDESKKISLFSNVPEDAVISVWDVDSIYKIPQMLHDQGLDRLICEELRLDPQPADLRMWAALVEKLQNPKHEVTIGMVGKYVDLTESYKSLIEALRHASIHTSTKVNIEYIDSEELETNGTASLAHLDAVLVPGGFGRRGTEGKIAAVRYAREAKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPNTPERVVALITEWYDREGKVEKRTEDSDLGGTMRLGSQRCPIKPGTLAEAIYGKDVNERHRHRYEVNNRFVPQLEAGGLVISARTPSEDLPEMMELPSTMHPWFVGVQFHPEFTSTPRDGHPLFKSFVQAALACQQTRAGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SR0</accession>
    <name>Q63SR0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">BPSL2260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191887.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108856.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2260"/>
    <dbReference type="EnsemblBacteria" id="CAH36263">
        <property type="protein sequence ID" value="CAH36263"/>
        <property type="gene ID" value="BPSL2260"/>
    </dbReference>
    <dbReference type="GeneID" id="56596054"/>
    <dbReference type="KEGG" id="bps:BPSL2260"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3171"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="45448" checksum="679BDE51706ECDC8" modified="2004-10-25" version="1">MFPDRIFSGMRPTGSLHLGHYHGVLKNWVKLQSEYPCFFCVVDWHALTTHYETPEVIEKNVWDVLIDWLASGIDPAQATLFIQSKVPEHAELALLLGMSTPLGWLERVPTYKEQIEKLKDKDLSTYGFLGYPVLMAADILLYRGSLVPVGEDQVPHVEMTREIARRFNYLYGREPGFEEKALEAAKKLGGKRAKLYHELRNAYQQEGDDEALEQARAMLQESQSLSMSDRERLFGYLEGARKIILVEPQALLTEASRMPGLDGQKMSKSYGNTIGLREDAETITKKVRTMPTDPARVRRSDPGDPDKCPVWQLHQVYTDETTHEWVQQGCRSAGIGCLDCKQPVVEGILREQQPMLERAQKYMDDPSLLRAIVADGCDKARKHATETMRDVREAMGLSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SR6</accession>
    <name>Q63SR6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108850.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2255"/>
    <dbReference type="EnsemblBacteria" id="CAH36257">
        <property type="protein sequence ID" value="CAH36257"/>
        <property type="gene ID" value="BPSL2255"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2255"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2562"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDQFVPE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="JmjC_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="PTHR13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="99"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="387" mass="43617" checksum="FBE56AE751E3C699" modified="2004-10-25" version="1">MSEAPTPLLGNLSPAQFMRRYWQKKPLLIRQAITGIAPPLSRDALFELAADYDVESRLVTHFRNRWQLEHGPFEPEHLPSVKRREWTLLVQGLDLHDDRARALLERFRFVPDARLDDLMISYATDGGGVGPHFDSYDVFLLQVHGKRRWRIGAQQDLSLQEGLPLKILANFEPTDEWVLEPGDMLYLPPHIAHDGIALGECMTCSIGFRAPSAGELRAQFLYHLAERGGLRTGARENARYRDPAQPAVDSPAMLPAAMVKRVAATLAGIQWDEHDVGDFLGCYLSEPKSNVVFEPPTRRLGEAAFVTQASRRGVRLDRKAALLYNARSYFINGDAHPLATAAKWLPELADTRRMEAKRFVTLSRDPAMTGLLHEWYCAGWIRVGDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SX2</accession>
    <name>Q63SX2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family C40 unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545914.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108794.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2199"/>
    <dbReference type="MEROPS" id="C40.006"/>
    <dbReference type="EnsemblBacteria" id="CAH36201">
        <property type="protein sequence ID" value="CAH36201"/>
        <property type="gene ID" value="BPSL2199"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2199"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3248"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPMKPED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266758" evidence="3">
        <location>
            <begin position="32"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="78"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="233" mass="24923" checksum="F0AA4FA38F80F70E" modified="2004-10-25" version="1">MQHRYLTQACTRVVAGMFVGILIAAAPGAFADEVSSSSQNAINSAQSEPASSSNLQQVNVPAPAKSQGGAKAFLSGMAGKAGDVVVGALNMIGVRYRWGGNTPDSGLDCSGFVRYVFQDTLGMSLPRRAEEMSRVGEKVRMSELKPGDLVFFNTMRRTFSHVGIYIGDNKFVHSPSTGSTIRVDDLDSGYWEKRFTGARRIETQFSTKPDDLRQRVKATIGDGGVNASASGSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T34</accession>
    <name>SSRP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name type="ordered locus">BPSL2137</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197080.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108732.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T34"/>
    <dbReference type="SMR" id="Q63T34"/>
    <dbReference type="STRING" id="272560.BPSL2137"/>
    <dbReference type="EnsemblBacteria" id="CAH36139">
        <property type="protein sequence ID" value="CAH36139"/>
        <property type="gene ID" value="BPSL2137"/>
    </dbReference>
    <dbReference type="GeneID" id="56595921"/>
    <dbReference type="KEGG" id="bps:BPSL2137"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3319"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000102924" description="SsrA-binding protein">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="148" mass="17212" checksum="B3265545A62E3DC4" modified="2004-10-25" version="1">MSIIDNRKAFFDYHIEERYEAGLVLEGWEVKALRAGRGQIKEGYVVVKHAEIFLIGTHISPLPEASTHIKPDPVRTRKLLLHRDEIKKLIGKVEQRGYTLVPLNFHYKGGRVKCEIGLAKGKKLHDKRETEKKRDWEREKARIMRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T86</accession>
    <name>Q63T86_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108680.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2081"/>
    <dbReference type="EnsemblBacteria" id="CAH36082">
        <property type="protein sequence ID" value="CAH36082"/>
        <property type="gene ID" value="BPSL2081"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2081"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2357"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="17175" checksum="B10D21E37998C0FE" modified="2004-10-25" version="1">MVGSRLAGLSIPIPRIGANEAIEFAPRACEPEFAARRRGMNGAFHRRRQYTGYMAGVSAEFKAFEEATSGAVMTKGFLWRSKIAAGFTNSGAHAGDKLSMLMQLVLFAARYGMHWVNLGLPPANDSTAGSPAELNRLGFGLGAGAQSNTDQGLDAAPPEQSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TM8</accession>
    <name>IHFA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integration host factor subunit alpha</fullName>
            <shortName evidence="1">IHF-alpha</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ihfA</name>
        <name evidence="1" type="synonym">himA</name>
        <name type="ordered locus">BPSL1939</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108538.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TM8"/>
    <dbReference type="SMR" id="Q63TM8"/>
    <dbReference type="STRING" id="272560.BPSL1939"/>
    <dbReference type="EnsemblBacteria" id="CAH35938">
        <property type="protein sequence ID" value="CAH35938"/>
        <property type="gene ID" value="BPSL1939"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1939"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2185"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYVRGFG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00380">
        <property type="entry name" value="IHF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00987">
        <property type="entry name" value="himA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000277721" description="Integration host factor subunit alpha">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00380"/>
        </source>
    </evidence>
    <sequence length="115" mass="12502" checksum="0C05095826F52B52" modified="2004-10-25" version="1">MARDVPASTPAGDTPTLTKAELAELLFDSVGLNKREAKDMVEAFFEVIRDALENGESVKLSGFGNFQLRDKPQRPGRNPKTGEAIPIAARRVVTFHASQKLKALVENGAEPDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TQ3</accession>
    <name>Q63TQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004534804.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108513.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63TQ3"/>
    <dbReference type="STRING" id="272560.BPSL1913"/>
    <dbReference type="EnsemblBacteria" id="CAH35913">
        <property type="protein sequence ID" value="CAH35913"/>
        <property type="gene ID" value="BPSL1913"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1913"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4057"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRVDANY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001442418" evidence="2">
        <location>
            <begin position="29"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="498" mass="53050" checksum="F836B5CA65869F9A" modified="2004-10-25" version="1">MKTFPLSACRTAVAVAVAALALAGCANYFGLKSDKAIAPAAQFESARSLPAQGGQWPSLDWANQFGDPQLPKLIDEALEGNPTIAQAQARIAKASSYIESSRSTLLPKADAKYSWTRELYSGNALFPPPYGGQWYSENNALASASWELDLWGKNRARLNAAVSQEKAAEADLQQARVTLATSVARTYNQLAQLYALRDIAGREISNRQTVGKITDGRVGAGLDTNVERQTARGNIATSQSTLSDLDGQITNVRYQLAALLGKGPDRGLQIAAPVLSAGGAVALPENLPADLVSRRPDLVAARWQVEAAMHDVKEAKAEFFPDINLAAGFGFDAFGWGRFLNFASRQAQFGPAIHLPIFDGGALRAQLKGRYADFDLSVANYNQTLINALNDVATQVASIRSVDTQMGDAQRALDASTRAYELAVIRYKAGLSPQLQVLNADSNRLAAEQTVTNLKMRRRDLQIGLVKALGGGFDAAGTRLAAPAPASAPAAPAQHASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TR4</accession>
    <name>Q63TR4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550549.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108502.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1902"/>
    <dbReference type="EnsemblBacteria" id="CAH35902">
        <property type="protein sequence ID" value="CAH35902"/>
        <property type="gene ID" value="BPSL1902"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1902"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4046"/>
    <dbReference type="eggNOG" id="ENOG502Z9MP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HATCATV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031929">
        <property type="entry name" value="CLP_mid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15984">
        <property type="entry name" value="Collagen_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266576" evidence="2">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen_mid" evidence="3">
        <location>
            <begin position="93"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="421" mass="38333" checksum="B3CB103D63A91937" modified="2004-10-25" version="1">MTQQRFAPSFALAAWGVPLTALATVCVLAACGGSDVTAPPSAGGGTSGTSGTSGTSGTSGTSGTSGTAGTSGVVNTLGKTATDLGNTISSTSVPGLGSGVTQGVGATVGSTGGIINAAADALSNGLGQTGSTQNPVGTTVAGLGNVVSATSNTVQGLSQTVQALGTGPLAPLSPVTTPVAGALATAANGVNAAGTMLGNALSTGPVQQVTQPISSALTPLVITAGQVTQTVGTTTGVGQPVSGLLQQVGGAISSAGTQIAGTSPSQPLVGDVGQLVSAVGNTVTNAGGLVNPAAPNGAAPIPGLITSVVGGSTATVATGSSSGSTLGSPLNGLLSSLGGGALPSGPLGGSAVSGGASNPLAPITSLASGGTGASTNPLAPVTGLLNTVTGTLSGATSSTGGSTGLLAPVTGSLGTLGSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UI1</accession>
    <name>Q63UI1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550391.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108235.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35620">
        <property type="protein sequence ID" value="CAH35620"/>
        <property type="gene ID" value="BPSL1621"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1621"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1828"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="116" mass="12034" checksum="4CDE71BC526036DB" modified="2004-10-25" version="1">MQRGRAHDRISDSRRAANRNRAAGAPVSAGSVRVVGQGDLPRAAGDALARRMSALVALFVMRPCGGVRAARVSMRDAEWSDFAAAVTEAGAEARLRCGLRIDDGAPAAHPLASAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UL4</accession>
    <name>Q63UL4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108202.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1582"/>
    <dbReference type="EnsemblBacteria" id="CAH35583">
        <property type="protein sequence ID" value="CAH35583"/>
        <property type="gene ID" value="BPSL1582"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1582"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1780"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NEWAENN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266348" evidence="2">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="339" mass="35113" checksum="44C61181566A9DB7" modified="2004-10-25" version="1">MRHAAARAVLAAAFTITLAAAPAGARAAPPLPALRADANRVSVSGLSSGAYMALQYQVAYSASVVGVGVIAGGPYYCAAGSVANTDLCRGLVPNMVPDSGRLVAAAQGFAASGQIDPLANLQRARIYLFSGTKDTLVRQSAVDATWSFFWLVGVPVTNIVYVADVPAGHAFVTPSAGNACDANAAPFISHCTVGQSGYDQAGALLDAIYGPLAPPAATPTGRAIAFDQREFAPASSGLAAQGYAYVPRTCDANAGCKVHVVFHGCLQSAAVVRDMTTYDNWADANGIVVLYPQVAKTSTPNDPQGCWDWFAYTGQNYAWKSGAQMRAVRAMIERVTSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UY8</accession>
    <name>Q63UY8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527184.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108078.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1456"/>
    <dbReference type="EnsemblBacteria" id="CAH35458">
        <property type="protein sequence ID" value="CAH35458"/>
        <property type="gene ID" value="BPSL1456"/>
    </dbReference>
    <dbReference type="GeneID" id="56529181"/>
    <dbReference type="KEGG" id="bps:BPSL1456"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3484"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRYAFWL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="235" mass="25352" checksum="E053541959D9251B" modified="2004-10-25" version="1">MGQFGRAVDEHGADAAHGSDRTAGAAADAAARGERFRALALPHLDAAYNLARWLCGNSSDADDVVQEACMRALRFLDSCRGDNARPWLLTIVRHTWYSEWRRRANAHEVAADALDAADSTDDWHPAVEDPLALLLRSEDAHRVNAALAKLPPEYREVLVLREMEDMSYREIAAIADLPVGTVMSRLARARRRLAATLGGAPASRSAAQGHPGERAAQRERGAPASGTASEAIDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UZ2</accession>
    <name>Q63UZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate carboligase</fullName>
            <ecNumber evidence="6">4.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gcl</name>
        <name evidence="6" type="ordered locus">BPSL1452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.47" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527189.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108074.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63UZ2"/>
    <dbReference type="STRING" id="272560.BPSL1452"/>
    <dbReference type="EnsemblBacteria" id="CAH35454">
        <property type="protein sequence ID" value="CAH35454"/>
        <property type="gene ID" value="BPSL1452"/>
    </dbReference>
    <dbReference type="GeneID" id="56529177"/>
    <dbReference type="KEGG" id="bps:BPSL1452"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3479"/>
    <dbReference type="eggNOG" id="COG3960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TLMGWGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01504">
        <property type="entry name" value="glyox_carbo_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="193"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="393"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="591" mass="64008" checksum="1922A98A8E0C11EC" modified="2004-10-25" version="1">MARMRAVDAAVLVLEKEGVQTAFGVPGAAINPLYSALRRSGAIGHVLARHVEGASHMAEGYTRAAPGNIGVCIGTSGPAGTDMITGLYSASADSIPILAITGQAPRARLHKEDFQAVDIESIAKPVTKWAVTVREPALVPRVFQQAFHLMRSGRPGPVLIDLPIDVQLAEIEFDIATYEPLPVYKPRATRAQIEAALAMLNDAERPLIVSGGGVINAAAEELLVQFAETLGVPVIPTLMSWGAIADDHPLMAGMVGLQTSHRYGNATLLASDFVLGIGNRWANRHTGSIEVYTKGRKFVHVDIEPTQIGRVFGPDLGIVSDAKAALELFVEIAREWKAAGKLKNRGAWVADCQQRKRTLQRKTHFDDVPIKPQRVYEEMNKAFGRDTCYVSTIGLSQIAAAQFLHVFKARNWINCGQAGPLGWTIPAALGVRAADPQRPIVALSGDYDFQFMIEELAAGAQFKLPYVHVVVNNAYLGLIRQAQRAFDMDYCVQLAFDNVNAPEMNGYGVDHVAVAEGLGCKALRVFKPEEIAPALERARQMTAEFSVPVVVEVILERVTNISMGAEIDAINEFEDLADKAEHAPTAISLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V26</accession>
    <name>Q63V26_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527206.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108040.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1418"/>
    <dbReference type="EnsemblBacteria" id="CAH35420">
        <property type="protein sequence ID" value="CAH35420"/>
        <property type="gene ID" value="BPSL1418"/>
    </dbReference>
    <dbReference type="GeneID" id="56529141"/>
    <dbReference type="KEGG" id="bps:BPSL1418"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3437"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YEQAKPT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266793" evidence="2">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="28783" checksum="F5129A54EFE9B309" modified="2004-10-25" version="1">MILKSPRLWAAAAALAAAPAFAQNIAVVNGTPIPKSRADAMIAQLVQQGQQDTPQLEQAVRQELVNREILMQEAIKRGIPNRPDVKAQIVVAQQTAVLRALIEDFLKKNQPSDTELKARYDDLVKNAGGREYHLHHILVDNEQQAKDLIAKIKGGAKFEDLAKQYSKDPGSAKNGGDLDWSDPKAYVPEFAAAAQQLQKGQMTDAPVKTQFGWHIIRVDDVRSITPPPFEQVKQQIAQQMVQQKLQAFEESLRQQAKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V60</accession>
    <name>Q63V60_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subfamily M23B unassigned peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108006.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1381"/>
    <dbReference type="EnsemblBacteria" id="CAH35381">
        <property type="protein sequence ID" value="CAH35381"/>
        <property type="gene ID" value="BPSL1381"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1381"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1550"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYRVERG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266614" evidence="2">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="24628" checksum="809D14AFEFE74BE3" modified="2004-10-25" version="1">MRGSMLLKTTRRLVVASLAALLAACGSAPVGPGFYRVERGDTLSKIARSNRQSVANIARWNQITNPDAIEVGQVLRVAPPPGTASTSGTTGASRGPSRQAPSSSATSPASSVKPASSISLVWPAAGSVIRSFDGSKSKGIDIANTAGTPVIAAAAGTVVYAGNGLRGYGNLLIVKHDADFLTTYAHNRALLVKEGQTVAQGQKIAEMGDTDNDRVALHFELRYGGRSIDPARYLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-06-02" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V80</accession>
    <name>Q63V80_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstA</name>
        <name evidence="9" type="ordered locus">BPSL1361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1361"/>
    <dbReference type="EnsemblBacteria" id="CAH35359">
        <property type="protein sequence ID" value="CAH35359"/>
        <property type="gene ID" value="BPSL1361"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1361"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="80"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="30646" checksum="423DF18349E25380" modified="2004-10-25" version="1">MPGPDGAALDAMRARLQRRRKATNVVALTASLAAMAFGLLWLVWILYTTLHLGVGGLSLALFTESTPPPNTAGGGLANAIVGSLLLVALATFVGTPIGILAGVYLAEYGQKSWLASVMRFINDILLSAPSIVVGLFVYALVVAKSGHFSGWAGVIALALLQIPIVIRTTENMLKLVPNALREAAFALGTPKWRMILKITLRASVGGIVTGVLLAVARIAGETAPLLFTALSNQFFSADMSQPMANLPVTIFKFAMSPFAEWQSLAWAGVFLITLGVLGLNILARSIFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VP4</accession>
    <name>Q63VP4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522420.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107822.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1200"/>
    <dbReference type="EnsemblBacteria" id="CAH35195">
        <property type="protein sequence ID" value="CAH35195"/>
        <property type="gene ID" value="BPSL1200"/>
    </dbReference>
    <dbReference type="GeneID" id="56526662"/>
    <dbReference type="KEGG" id="bps:BPSL1200"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.327"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFFDFFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="290" mass="32114" checksum="351D2527261B919A" modified="2004-10-25" version="1">MAAFKPRRPRNGNAPWPRSFRHKKSVAQDVAPVESRRAARQQFLRTRGIYLLPNAFTTAALFCGFFAVVQAMNVRFETAAIAIFAAMVLDGMDGRVARMTHTQSAFGEQFDSLSDMVSFGVAPALVMYEWVLKDLGRWGWLAAFVYCSGAALRLARFNTNIGVVDKRFFQGLPSPAAAALIAGFVWLATDNRVPMKLGWLPWVAFVLTIYAGVTMVSNAPFYSGKALDVRHRVPFAAILLVVVAFVLVSSDPPLMLFGLFVLYGLSGYVFWAYMAVRGRANPARSSQREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VR0</accession>
    <name>Q63VR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar-related transport, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204962.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107806.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1184"/>
    <dbReference type="EnsemblBacteria" id="CAH35179">
        <property type="protein sequence ID" value="CAH35179"/>
        <property type="gene ID" value="BPSL1184"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1184"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1309"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPRECLL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="45808" checksum="2D56CC0A91077378" modified="2004-10-25" version="1">MAGMAGVDGVDGVDGADAARADARRDVAAVALGNAIEFFDFGAYATFAVMIGRTFFPTQRPFVSLLLSVSVFGLGFVVRPLGALVIGAYADRAGRKPAMTLTLAMMAVGTGAIAVLPGYETIGVAAPILLVVTRLIQGLAWGGEAGPATTYILEAAPPERRAAYACWQVATQGFAAVAAGLAGYALTLALPEAELDAWGWRVPFALGLLVLPVGVYIRRRLSDTIDPRHAYCTTREILRELNARHRRPIAIGLMILLGSTITQYFLNYMTTFALTELHLPGGVAMLATFVTGAALAVGALAGGSLSDRVGRRAILIWPRVLLLLLLFPALQLIVSRPTPAVFLATLTVLSGLHGMSGAALIVLIAESFPQRVRSTGFSIVYAVAVSLFGGTAQSIVTWLIGTTGNPMAPSGYLLVANAICIAAGWLAAETRPGGRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VU8</accession>
    <name>Q63VU8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2016" name="Gene" volume="577" first="140" last="147">
            <title>Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4.</title>
            <authorList>
                <person name="Werten S."/>
                <person name="Kohler C."/>
                <person name="Bayer N.J."/>
                <person name="Steinmetz I."/>
                <person name="Hinrichs W."/>
            </authorList>
            <dbReference type="PubMed" id="26625975"/>
            <dbReference type="DOI" id="10.1016/J.GENE.2015.11.037"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936865.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107768.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="5A4N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.96 A"/>
        <property type="chains" value="A/B=1-75"/>
    </dbReference>
    <dbReference type="PDB" id="5A4O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.76 A"/>
        <property type="chains" value="A/B=1-75"/>
    </dbReference>
    <dbReference type="PDBsum" id="5A4N"/>
    <dbReference type="PDBsum" id="5A4O"/>
    <dbReference type="SMR" id="Q63VU8"/>
    <dbReference type="STRING" id="272560.BPSL1147"/>
    <dbReference type="EnsemblBacteria" id="CAH35141">
        <property type="protein sequence ID" value="CAH35141"/>
        <property type="gene ID" value="BPSL1147"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1147"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.393"/>
    <dbReference type="eggNOG" id="ENOG5033BJS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIWFAAE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="SSF54447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PC4" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5A4N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5A4O"/>
        </source>
    </evidence>
    <sequence length="75" mass="8542" checksum="ECCD5581976A5644" modified="2004-10-25" version="1">MSAYDSGKTIADVQKSATQRIRISHRWYRGRRYVDVRLVVVDRDGDFVPTRQGISIRPELLAQVIQGLLLASREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W85</accession>
    <name>Q63W85_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL1003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191939.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107631.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1003"/>
    <dbReference type="EnsemblBacteria" id="CAH34999">
        <property type="protein sequence ID" value="CAH34999"/>
        <property type="gene ID" value="BPSL1003"/>
    </dbReference>
    <dbReference type="GeneID" id="56596186"/>
    <dbReference type="KEGG" id="bps:BPSL1003"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.566"/>
    <dbReference type="eggNOG" id="COG1982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WSTLLTE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00703">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="4">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="759" mass="85417" checksum="6A08DCB57B1ADE79" modified="2004-10-25" version="1">MKFRFPVVIIDEDFRSENISGSGIRALAEAIEKEGVEVLGLTSYGDLTSFAQQSSRASCFILSIDDDELMLGELGADGELPELATAIIELRAFVAEVRRRNADIPIFLYGETRTSRHLPNDILRELHGFIHMFEDTPEFVARHIIREAKVYLDSLAPPFFKELVKYADEGSYSWHCPGHSGGVAFLKNPLGQMFHQFFGENMLRADVCNAVDELGQLLDHTGPVAASERNAARIFSADHLFFVTNGTSTSNKIVWHATVAPGDIVLVDRNCHKSILHAITMTHAIPVFLTPTRNHFGIIGPIPRDEFKPENIRKKIEANPFAREALRKNPNAKPRILTITQSTYDGVVYNVEQIKDLLGDLVDTLHFDEAWLPHAEFHPFYQDMHAIGAGRPRTGALVFATHSTHKLLAGISQASQIVVQDSENRTFDKHRFNEAYLMHTSTSPQYAIIASCDVAAAMMEPPGGTALVEESIAEAIDFRRAMRKVDAEYGDDWFFSVWGPDNLSEEGIGSRADWLLKPNDRWHGFGPLAPGFNMLDPIKATIITPGLDVDGEFGETGIPAAIVTKYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSMVTELQQFKDDYDNNQPLWRVLPEFVAQYPLYERVGLRDLCTQIHDVYRANDIARLTTEMYLSNMEPAMKPSDAFAKLAHREIDRVPLDELEGRVTSILLTPYPPGIPLLIPGERFNKTIVNYLRFARDFNERFPGFHTDIHGLVAEEMNGRIEYYVDCVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WB0</accession>
    <name>Q63WB0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ATP-binding ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192006.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107606.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0978"/>
    <dbReference type="EnsemblBacteria" id="CAH34974">
        <property type="protein sequence ID" value="CAH34974"/>
        <property type="gene ID" value="BPSL0978"/>
    </dbReference>
    <dbReference type="GeneID" id="56596212"/>
    <dbReference type="KEGG" id="bps:BPSL0978"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.596"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HHADRVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="14"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="276" mass="29800" checksum="C3147AB2D6552043" modified="2004-10-25" version="1">MTMHDAPTSRPTRYGTRHLVLKAGARTLLDDFTHTFEPGELWCVAGPNGAGKTTLITTLAGLAKPAAGHVEADGAPLAAWRPEALARRRAWMAQTLHDAFSASVLDTVLLARFPHLPGWGWERADDHAAARAALARLGLEAFAARDVLSLSGGERQRVALAAALCQDAPLLLLDEPLAHLDLHHQIDCLAALADWLRAGERTAIFSCHDLNLARRFATHALLLDGEGGAHAGPVRDVLTPERASRAFGYPLVLIERDGHEALVPAWPDARERARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WK2</accession>
    <name>Q63WK2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522619.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107514.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0889"/>
    <dbReference type="EnsemblBacteria" id="CAH34881">
        <property type="protein sequence ID" value="CAH34881"/>
        <property type="gene ID" value="BPSL0889"/>
    </dbReference>
    <dbReference type="GeneID" id="56594734"/>
    <dbReference type="KEGG" id="bps:BPSL0889"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.701"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFGECPR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021317">
        <property type="entry name" value="DUF2917"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11142">
        <property type="entry name" value="DUF2917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="111" mass="12451" checksum="455C3822F8A00476" modified="2004-10-25" version="1">MREIHTYVLDYPEPAAVWCASHDATLRVSAGEAWLTVDGRRDDYWLGAGEAFELPRGACVRIGAGRGGARIEVMRTVAVLEPPFWRDAAARVRARWSARRRRAQAVWSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WP1</accession>
    <name>Q63WP1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189275.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107475.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0850"/>
    <dbReference type="EnsemblBacteria" id="CAH34842">
        <property type="protein sequence ID" value="CAH34842"/>
        <property type="gene ID" value="BPSL0850"/>
    </dbReference>
    <dbReference type="GeneID" id="56596512"/>
    <dbReference type="KEGG" id="bps:BPSL0850"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.749"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFAMKGR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="171" mass="18391" checksum="E65CED23D7511CB4" modified="2004-10-25" version="1">MKHLQASPPNFDTAAFRQALGQFATGVTVVTTRAPSGQLIGITASSFNSVSLDPPLVLWSLAHKSASMPVFRTNSHYVVNVLSASQHDLCMRFATLKGNRFEGVSHAQGDSGMPVLDGALAWFECHNRSRYDEGDHVIFVGEVERCGVHPDAAALAPLVFQSGGFHGLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X00</accession>
    <name>Q63X00_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34732">
        <property type="protein sequence ID" value="CAH34732"/>
        <property type="gene ID" value="BPSL0740"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0740"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="54" mass="5419" checksum="7A0BC5EB12F0C0CE" modified="2004-10-25" version="1">MEMSAIVRGRVVGARAVGDRAVMLDLSGELVAVDGVKAGGGDRVASPVRLGPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X17</accession>
    <name>Q63X17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative cytochrome c oxidase polypeptide II</fullName>
            <ecNumber evidence="18">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">BPSL0723</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="18"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107349.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0723"/>
    <dbReference type="EnsemblBacteria" id="CAH34715">
        <property type="protein sequence ID" value="CAH34715"/>
        <property type="gene ID" value="BPSL0723"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0723"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.791"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMTGTYP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04213">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034236">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="16">
        <location>
            <begin position="157"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="17">
        <location>
            <begin position="283"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAH34715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="373" mass="39601" checksum="190CC9BD6D178753" modified="2004-10-25" version="1">MSVKPAQRPERGFAKTRRRTAAYRPAATRAAGVARAAGAATPPLAAALHAAAAHAQAHAAQPAALPLAYVFDSAGPAARPVLILGWALLALCTSVCVVIAVLLALALFRRRAATAGLTERGGLGFVYAGTAISTALLLAALVYMLWVLAAVAKPPRPPAVTIAVTAYDWWWKADYGGGPPDGFTTANELHVPVGEPVLIELRSADVIHAFWAPQLAGKTQAIPGQINRQWMQADRPGVYRGQCTQFCGAQHAQMGFEIVAEPPDAYRRWYASQRRGAEAPRTADALRGQRIFADRCAGCHAVRGTGAAGTQAPDLTHVGARRLLAAGALANTPDELRRWIADAQQVKPQSLMPSIRLDPAQQRDLSAYLATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XI0</accession>
    <name>Q63XI0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Couple_hipA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204819.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107185.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0559"/>
    <dbReference type="EnsemblBacteria" id="CAH34549">
        <property type="protein sequence ID" value="CAH34549"/>
        <property type="gene ID" value="BPSL0559"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0559"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1090"/>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017508">
        <property type="entry name" value="HipA_N1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13657">
        <property type="entry name" value="Couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Couple_hipA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20322" checksum="DB5E3CC0D74FBCE8" modified="2004-10-25" version="1">MATTKKAKTSTTRTLLVYLGDTGLEVGELQFSRQGQKEVSAFRYSPAWLSNPDCFALSPDLPLSTDFQYRTGSKETSTFAGAIADTEPDGWGRRVIDRAHAKRRKADGPFLDVPHDDNLPEGTHEVPLQTLIQASNAVESGKETAMAALCGRCMFDAAYELGVNSVCYGARQCRTFESVEWTDVM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y16</accession>
    <name>ACEK_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase kinase/phosphatase</fullName>
            <shortName evidence="1">IDH kinase/phosphatase</shortName>
            <shortName evidence="1">IDHK/P</shortName>
            <ecNumber evidence="1">2.7.11.5</ecNumber>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aceK</name>
        <name type="ordered locus">BPSL0373</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]</text>
            <dbReference type="Rhea" id="RHEA:43540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10605"/>
            <dbReference type="Rhea" id="RHEA-COMP:10606"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AceK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.5" evidence="1"/>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525974.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106999.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Y16"/>
    <dbReference type="SMR" id="Q63Y16"/>
    <dbReference type="STRING" id="272560.BPSL0373"/>
    <dbReference type="EnsemblBacteria" id="CAH34361">
        <property type="protein sequence ID" value="CAH34361"/>
        <property type="gene ID" value="BPSL0373"/>
    </dbReference>
    <dbReference type="GeneID" id="56594621"/>
    <dbReference type="KEGG" id="bps:BPSL0373"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1296"/>
    <dbReference type="eggNOG" id="COG4579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EPWYSVG"/>
    <dbReference type="BRENDA" id="2.7.11.5">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008772">
        <property type="term" value="F:[isocitrate dehydrogenase (NADP+)] kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00747">
        <property type="entry name" value="AceK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010452">
        <property type="entry name" value="Isocitrate_DH_AceK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39559">
        <property type="entry name" value="PTHR39559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06315">
        <property type="entry name" value="AceK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000719">
        <property type="entry name" value="AceK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0329">Glyoxylate bypass</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_0000057897" description="Isocitrate dehydrogenase kinase/phosphatase">
        <location>
            <begin position="1"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="327"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00747"/>
        </source>
    </evidence>
    <sequence length="603" mass="69894" checksum="EB035EFF2E5EFB82" modified="2004-10-25" version="1">MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITSYDDRVRECVELLEDEYDAENIDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRHARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDTTREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGENLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y55</accession>
    <name>Q63Y55_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522997.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106960.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0333"/>
    <dbReference type="EnsemblBacteria" id="CAH34322">
        <property type="protein sequence ID" value="CAH34322"/>
        <property type="gene ID" value="BPSL0333"/>
    </dbReference>
    <dbReference type="GeneID" id="56527423"/>
    <dbReference type="KEGG" id="bps:BPSL0333"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1348"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHNTRGT"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="32434" checksum="AEBF65508A100A60" modified="2004-10-25" version="1">MTLPQSVKIVEVGPRDGLQNEQTFVPTGVKIELVNRLSQAGFRNVEAASFVSPKWVPQMADGADVMAGIARRAGTIYSALTPNLKGVENALAARADEVVIFGAASEAFSRRNINCSIAESIARFEPVARAAKDAGVRLRASVSCALGCPYQGDVPLEAVVDVVERLAALGCDEIDIADTIGVGTPGRTRAVLDAVAKAFPRERLSGHFHDTYGQALANIYAALLEGIAIFHASVAGLGGCPYAKGATGNVATEDVLYMMRGLNIETGVDLDQVVAAGDFISNAIGRANISRAGRALLAKQRAAAEPPSACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y58</accession>
    <name>Q63Y58_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550324.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106957.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0330"/>
    <dbReference type="EnsemblBacteria" id="CAH34319">
        <property type="protein sequence ID" value="CAH34319"/>
        <property type="gene ID" value="BPSL0330"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0330"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1352"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FVEIYCR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="162" mass="18067" checksum="000423FA6CEB21D9" modified="2004-10-25" version="1">MQKRLSTPFAAANTLDAIDRELLRTLADDARLPVSELARRVGLSAPSTADRLRRLEAQGVIARFTVELDPRALGYTLQAIVRVKPLPGQLHLVEELLRRIPEFVECDKVTGDDCFVCRLYLHSIEQLDGILAKVTERAETSTAIVKSTPVARRLPPLAREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y80</accession>
    <name>Q63Y80_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936048.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106935.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0308"/>
    <dbReference type="EnsemblBacteria" id="CAH34297">
        <property type="protein sequence ID" value="CAH34297"/>
        <property type="gene ID" value="BPSL0308"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0308"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1381"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NEPLYWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021647">
        <property type="entry name" value="CusF_Ec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042230">
        <property type="entry name" value="CusF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11604">
        <property type="entry name" value="CusF_Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266861" evidence="2">
        <location>
            <begin position="22"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="123"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="523" mass="55120" checksum="8AE46417EC5CC320" modified="2004-10-25" version="1">MNHIRLTRAALAVLAAVALSAAGYFAGARFGAHVDVAHRAHAMNTTNAVDGADAKPGRKVLYWRDPMVPNQHFDKPGPSPFMNMPLEPVYADDGGGAPGVRIDPGLQQNLGIRYAKVRRRDVDEGFDAVGTTQFDESRTAVVQSRVTGYVDRLYASAPLQRIAKGAPIASLFVPDWLAPQEEYLALKRGAMDEALLAASRARMRALSIPDSVIANLDRTGRAQTHIVLASPETGVVSELNVRDGAMVTPGQTLAKIAGLSTLWAVIDVPEALASGVRPGMRVDATFEGDPQRRVSGAIREILPGVNATTRTLQARLELDNRALALTPGMLMRARVGASHAASRLVVPSDAVIATGKRSVVIVRTADDRLRPADVTVGRDAGDETEVLAGLEEGETVVASGQFLIDSEASLKSVLPRLEADASGALVARATRPPARSSPPAAQAGGAAPVYETTGKVEKITAADITFSHQPVPALGWGAMTMSFDKPAPAAFANVKAGDTVRFAFEASGDGYRLTKVEPVGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YN5</accession>
    <name>Q63YN5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage-related tail fiber protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106780.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0152"/>
    <dbReference type="EnsemblBacteria" id="CAH34139">
        <property type="protein sequence ID" value="CAH34139"/>
        <property type="gene ID" value="BPSL0152"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0152"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.163"/>
    <dbReference type="eggNOG" id="COG4675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QDDTSDQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="790" mass="83385" checksum="138189A709BFFBE1" modified="2004-10-25" version="1">MAGMVIHITDAGRAALVAGGNTGTAAHRVVEIGLGTAPFAFDRGMKTMPNEHKRVSTFGGENVAPDTVHVVIQDDTSDQYSLYAFGLYLENGVLFAVCVQDAPILEKSPAAMMLLATDVVFATIDAAKLEFGPATFLNPPATTERKGVVELATQAEVDAGDDDTRAITPKTAKRRYAALSGATFDGRVRVFADVDDRAAQLDVSPKTAGVGKAGKARLFGTFGDATLPDLSPRLVATLRAGFDAGAWGREYVDVCLNDGTNNDAASDAKQKRVARFASGGRVLIGERADDGKTALQVRGGVDASEGVAARAIDAGGAGGQFRAVYDGYGAFIRNDGRSVYFLSTPKGAPDGGFNDYRPFSWSLSTGQVIVDGSGAGTVFGGAVDVARDLEVGRQASEGHIKLGPVDGYLYANPVSTGWWSPAGSSYQYIFADHTFRIDGRMAWHEGNLDPLDKSKGGMLAGDVSFAPGKRLVLAEGSPAAPSLTFANDGAPDTGLYYAADGEFGVTCNGRAVVRFSPSLVAFEQPVTVPTPPAADRSTRAATTEWVRTVLSATTIGQIVFEPRTTVRPGFLKANGVLVNRADYPELWAYAQASGALVSDADWMKDRWGCFSTGDGATTFRLPELRGEFIRCWSDARGGVDATRQIGAFQGDQNHTHAHGAAASEAPDHVHTAWTDVQGWHGHHGWTNAVGDHQHVSPWGEHPQMYNPPWGTWGAANNRGAEGSDNDNVYGMTSPAGNHNHEFNTEGNGNHGHAVGIGGGGRHAHTIAVQPDGGDEARPRNVALLALIRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YT8</accession>
    <name>Q63YT8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-3-methyladenine glycosylase II</fullName>
            <ecNumber evidence="3">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.21" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553741.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106727.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0101"/>
    <dbReference type="EnsemblBacteria" id="CAH34085">
        <property type="protein sequence ID" value="CAH34085"/>
        <property type="gene ID" value="BPSL0101"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0101"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1629"/>
    <dbReference type="eggNOG" id="COG0122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLWRSIE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052822">
        <property type="term" value="F:DNA-3-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052821">
        <property type="term" value="F:DNA-7-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlkA_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="144"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="313" mass="33205" checksum="C9C2D3FD4BEF695E" modified="2004-10-25" version="1">MSAAVEPAAVRPDSVVLELPFKSPYDWPRVLRFFAGRAIPGVEAVGDGAYRRTVDHHGAIGTLTVRKHPRKRCLVALVEGDAARHADAAFAARLSTMFDLQADPAAIGAHLARDAWFAPLVGAAPGLRVPGAWSGFELIVRAIVGQQVSVKAATTIVGRLVERAGERLAPHAPGAIGWRFPEPAALAACDVSRIGMPGKRAAALQGVARAVASGDVPLEAYASDPAGVRAALLALPGIGPWTVEYVAMRAWRDADAWPATDLVLMQAIVARDPALDRPASQRLRADAWRPWRAYAAMHLWNEIADRAGSARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YZ4</accession>
    <name>Q63YZ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530488.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106671.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0046"/>
    <dbReference type="EnsemblBacteria" id="CAH34029">
        <property type="protein sequence ID" value="CAH34029"/>
        <property type="gene ID" value="BPSL0046"/>
    </dbReference>
    <dbReference type="GeneID" id="56527676"/>
    <dbReference type="KEGG" id="bps:BPSL0046"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1697"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TIMGLWQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="243" mass="25112" checksum="28BF8A142EB03C66" modified="2004-10-25" version="1">MQLEVKNLVVHRANKPVLHGVSLAVTPGRVTALVGANGAGKSTLVMSIAGALPATSGDVLLGGAPLGALRPEAVRRLGVAVVPEGHHVLGDLTVRDNLRAAGAFLSARRLNGAIDRALAIFPELEPKLDARANDLSGGQKQMVCVSQALIGEPHTLLIDELSLGLAPTVTKRLAQTVARIANDGVAVLLIEQFTTIALALSTNAYVLERGRVAFAGSAQTLRERPEILHGSYLASKGSGANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z17</accession>
    <name>Q63Z17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549840.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106645.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0020"/>
    <dbReference type="EnsemblBacteria" id="CAH34003">
        <property type="protein sequence ID" value="CAH34003"/>
        <property type="gene ID" value="BPSL0020"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0020"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1727"/>
    <dbReference type="OMA" id="VTEPSTW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="90" mass="9636" checksum="D2AD0673424DD1D3" modified="2004-10-25" version="1">MPFLKQAAGALRRNLSDTARHTLSGPHRGWKIALYAALLIVPGGSLAALGFAWFDQRRHRTAGMRAASAQEPSAPMLCLAATHGEPVRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HS6</accession>
    <name>Q63HS6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190980.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112346.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2344"/>
    <dbReference type="EnsemblBacteria" id="CAH39830">
        <property type="protein sequence ID" value="CAH39830"/>
        <property type="gene ID" value="BPSS2344"/>
    </dbReference>
    <dbReference type="GeneID" id="56598458"/>
    <dbReference type="KEGG" id="bps:BPSS2344"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5983"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KALPPDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="122" mass="13329" checksum="120B3C829D2CE3AE" modified="2004-10-25" version="1">MPLPIVIADDSLLARKLLTKALPADWDVDVNYASNGREALALYRDGKASVMFLDLTMPDMSGYEVLETLRGEDLNTFVIVVSADIQPMAQARVRELGAAAFVAKPVTSEALLPILKEYGLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HV8</accession>
    <name>Q63HV8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family U62 unassigned peptidas</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552292.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112314.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2311"/>
    <dbReference type="EnsemblBacteria" id="CAH39797">
        <property type="protein sequence ID" value="CAH39797"/>
        <property type="gene ID" value="BPSS2311"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2311"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5942"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HYLNWSD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="229"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="453" mass="48562" checksum="4547D5F432DDF94C" modified="2004-10-25" version="1">MTDFAKPGRAAPIDWHAHFARLADEAEQLRRPGETVLLWFAGETSDFIRFNAGKVRQTGRVVQGKLAVRLASGGRQASFAQTVSGDWATDAPELAAALATLRESLRDAPDDPHLLFDTSSWRQSSCRDGSLPDPDALAHVVADAARGLDFVGFYAGGSLARGFASSTGSRGWYEVENFDFRWSLYDASGRAIKTVYAGESWSDAAFARKVDEAAARLPALGRAPKALAPGRYRAYLAPAAVAEIVGLLGWDGFSARANASARSSLHRLHAGEAAFDPRVTIAEDFSLGVAPAFNADGYRRDSVPLVAEGRSVGRLVSARTAREHGLSPNGAAADETPETLSIAGGALADADVLAALDTGLYIGNLWYLNFSDKMNGRITGMTRFATFWVERGRIVAPVDAMRFDDSVYRLLGAELEQLGAAPELLLNDQSWSERPTGGAKLPGLLARSFELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I10</accession>
    <name>Q63I10_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative fusion protein, ATP-binding transmembrane ABC transporter and regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSS2259</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529468.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112262.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2259"/>
    <dbReference type="EnsemblBacteria" id="CAH39745">
        <property type="protein sequence ID" value="CAH39745"/>
        <property type="gene ID" value="BPSS2259"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2259"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5862"/>
    <dbReference type="eggNOG" id="COG5265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EFEHVDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="41"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="363"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="836"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="750"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="396"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH39745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="988" mass="105891" checksum="D3803D13B222FA6A" modified="2004-10-25" version="1">MTTPADPAARANHAERAGRGLRARIALDLWRAIRRYRLRVLAALALLVLAKAAAVAVPLLLKQIVDELGRVAAHPFALPVLLLFGYAVVRFASNALNEVRDMTFVHVTQRTVADFTVRTFAHLHRLGARFHARRETGAVVRDLEKGTAGIGYLLGIAVFTIVPTVLEIGAVLVVVIGKYGGGFTAIIFVTFAVYAAYTFVFTRRRMRLQRRVNALEARSNGRIVDSLLNYDTVKYFAREDFERERLDTVLDDWREAGIDNQFALSTLHIGQSACIGAGIAAVMLLAGERVVSGVMTVGDLVLINAYIIQISLPLNALGFVFREANDALTNVERLFALLDARGKPGEDGDAPFAQPLAVRGGEIRFEHVDFGYEPGRQILWDVSLAIGAGETVAVVGGSGSGKSTLARLLFRLYQPDAGSISIDGQDLRLVTERSLRDAIGIVPQDTILFNDTLAYNIGYGRRDATRADIVAAARGAQLDALIERLPDSYDTRVGERGVRLSGGERQRVAIARALLKAPPIVVFDEATSALDTRSERAIQDELMRIAEHRTSLVIAHRLSTIVDADRIVVMEHGRLVEQGTHDELLDRGGVYAQMWALQAKQREFERTEARIALHAVRINPLVAHVLDSLREVADTRGVPLFSHLAEDDLVVTADPAALRRIVWDLCRGGIDASRAGGRVEIVTARAGNDARISVSSVGADAPELSLPNLETMQAALESQGGYVARGRDDVGIVVHLALPLNAIDTAAPPAAAPGGARAGTNGNADGRPSGHPDGAVPGATRGAANASPNGAASGGTNGRVNGGANGGQNGVATSADIAPPSVAAAATAGRPLDRVTIACVDDHDDARDALSALLSDAGARVLAFGSGQALLDRLWQMRRRDWPAALVCDIDLGDEDGCTVMTQVRQLEHARRDDGARAVEALALSGYASEHDRARAIEAGFRGYLTKPVKAVDLIAALRALAFHRGESDEHVEHPATEREGADERARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IT2</accession>
    <name>Q63IT2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PNP_UDP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941096.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111990.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1984"/>
    <dbReference type="EnsemblBacteria" id="CAH39462">
        <property type="protein sequence ID" value="CAH39462"/>
        <property type="gene ID" value="BPSS1984"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1984"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5489"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WATIAGE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="163"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="968" mass="106682" checksum="415E0A768583EC1A" modified="2004-10-25" version="1">MNAHLPAGALVPLVTRHTDIAIAAPLRGTTTLPPVAWERIGQRAPVRIAPGARAPDDPLPRADIVVITWTSAEWFALDHVFVDSAHTGDYNDYAWKQAWLPYTRGASPYAADAKSGALWGLFQMVRIVDRSGRPWNVLLFKSNAHLAHSPWLDGLSAMLRCIVEDARPDRIYTIGTAGGARHDQRLGDTVLANAALLELQRPQNATSPEGGNMYRCPTWYPSTALVGEVESQLLFRMSEIVTPQSLAALFDELKARHPDDPGLGELTLADLLNDAIRPECLRTPAIRPLKDAPLLTTDFYYIAEGNDAHAYSCLEMDDAIIAQQANRLGVRFACVRNISDPIVRRRTDRGTPISEAVRADWSGLIYSTFGLQTSYNGALATWATIAGEGSAAYNPIREHPPADEADPLEVQLAFQVRSCGTCSFFWPADPKKRTYGPYTAFDFDTTVPYPASANGRSGAVRWLSGRTRPPAFPNGEVIDGCRKAPIMTIGINPNLTAFLPGQTGAAWCYPDFSSDGDTDAWAKYAWYYRYRTVYQEKLDLDFVRRFMLPERRVIAARGGEVTGAARIDDNPAWSITVRYDGDAADTTIPIPGEPGDFPYVLLFDTYRPHNRFAAGDVLASRVSVPEGIQVEVLQQPQSYYLQMVPVLERFERTLRDGGHPGASLHVGEDVCQLDMVACASPHWKPGFLGGSDASVTAIVDNCVSRNAWAIKQMVQTRPALLYIVSESSWNMFHAALGAHVRRDPPLSSHPADKDYTLLKETTDPEHPAYVEFDVTIDGMRYAHRTRLVITPHFSYNSFFLQQYRMSTQDWHAFGAAQPGCVAALTPQNGFTLVLPTQAYPDDYVAIQLPADASAANAARAWLASQFPDAARTLGTYFVDAHASMASVLDELYANHTLTWHDTDSGGYLSRNEGSCRFCVNRHWQFPNECRYDKTHEPPPPAGFLAKVARHLVATGKPAAENATTGAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J84</accession>
    <name>Q63J84_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative lipopolysaccharide biosynthesis related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111838.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1834"/>
    <dbReference type="DNASU" id="3096118"/>
    <dbReference type="EnsemblBacteria" id="CAH39310">
        <property type="protein sequence ID" value="CAH39310"/>
        <property type="gene ID" value="BPSS1834"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1834"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6161"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PKYPDRH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017473">
        <property type="entry name" value="Undecaprenyl-P_gluc_Ptfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03023">
        <property type="entry name" value="WcaJ_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="280"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="471" mass="53487" checksum="BCDDEBA17BA6A8BF" modified="2004-10-25" version="1">MRPVSVSRGRTMLSVLARMIDIAMAVAGAMIAAMIHRGGFVWLDDLQRTVVVFDCMLVVVFFPAFGIYQSWRGKPVFGLMWRVSVAWLVVEGAGILMSFSVHHAGELSRLWLGYWAMATITLLVASKACVYAVLRQLRRGGYNHKSVAIVGRAQASATKRLIAHMRARPDAGFNPVCIYDEHDDASTGETDGIAIERRFGHLVRRVRSREIGELWLVLPLSEEPQIHRIVTEFRNDFVNIRFVPDVRSLSFFNQEVIELLGVPAINLAASPITDVRILPKFVFDRLFALVALMMLSPAMLVIATLVKLTSPGPVFFRQKRKGIDGNEFEIYKFRSMKVHQEMGGKVTQARKNDSRVTPVGRFLRRTSLDELPQFINVLKGEMSVVGPRPHALEHDDIYKDLVKGYMFRYRIKPGITGWAQINGFRGETDRIEKMMGRVKLDLYYMQNWSFWLDIKIVALTLWKGFTGSNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI3</accession>
    <name>Q63JI3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111739.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1733"/>
    <dbReference type="EnsemblBacteria" id="CAH39208">
        <property type="protein sequence ID" value="CAH39208"/>
        <property type="gene ID" value="BPSS1733"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1733"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5159"/>
    <dbReference type="eggNOG" id="ENOG502ZU49">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="44" mass="4769" checksum="2B08B0FD5C9C8A7E" modified="2004-10-25" version="1">MKRIGAFFIATWTAAALLYLGRHSVPMIAMSGVVAFAGFDLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JJ5</accession>
    <name>Q63JJ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111727.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1721"/>
    <dbReference type="EnsemblBacteria" id="CAH39195">
        <property type="protein sequence ID" value="CAH39195"/>
        <property type="gene ID" value="BPSS1721"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1721"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5138"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SRYSFEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="29568" checksum="E124664391DA3CCB" modified="2004-10-25" version="1">MTSNQASAPNPNGQAGSTQPGGEAAAAPSPTFSPLYRQIKALITQSLEAGEWKPGEIIPSEVELAGRYKVSQGTVRKAIDELAADNLLVRRQGKGTFVATHSEERAQFRFLRLLADDGAEHPHVSRLLECRRMRAPAEIARQLDLKPADPVVQVRRVLEFDGVDTVLDEIWLPGAMFRGLTFERLSEYKGPLYAMFESEFGTRMIRASEKIRAIAAEPAVADVLRVPPGFPLLSVERVSYTYGDRPVEVRRGWYVTTGYYYQNDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JJ6</accession>
    <name>Q63JJ6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate dehydrogenase cytochrome b556 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="9">The heme is bound between the two transmembrane subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536542.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111726.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63JJ6"/>
    <dbReference type="STRING" id="272560.BPSS1720"/>
    <dbReference type="EnsemblBacteria" id="CAH39194">
        <property type="protein sequence ID" value="CAH39194"/>
        <property type="gene ID" value="BPSS1720"/>
    </dbReference>
    <dbReference type="GeneID" id="56598077"/>
    <dbReference type="KEGG" id="bps:BPSS1720"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5137"/>
    <dbReference type="eggNOG" id="COG2009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SWAFLHH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="PTHR10978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000178">
        <property type="entry name" value="SDH_cyt_b560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with second transmembrane subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000178-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="138" mass="15646" checksum="27667E4C366E9259" modified="2004-10-25" version="1">MSETVRKPRPEYRNIGFGDITLKYRMPLAARVSILHRVSGALLFLFLPFLLYLFDQSLTSELSFEVFKAFLSNIIVKLIVLALSWAFLFHFCAGIRHLMMDMNHDAVSKERGKKTSVVVFAVSTLLTIAVALKLFGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JK7</accession>
    <name>Q63JK7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205666.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111715.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39183">
        <property type="protein sequence ID" value="CAH39183"/>
        <property type="gene ID" value="BPSS1709"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1709"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5123"/>
    <dbReference type="eggNOG" id="ENOG5033TXZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDANGCH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="33795" checksum="70B3070A3991D12B" modified="2004-10-25" version="1">MTRYEMKRQGGTQAEGPPVDFGRMHEEFRRAEDADLRALVDENLRRAEREWRRIQPAIDRSAGDGDAALGAARPCACEAPGACDQPDLPDVPDPPIASDPADAPLAPSSGAHARAASCGHATKTLIPGYPVLDADRPSVGEFVAFVADMRNSSARFSEAAAFPHVRCGLQRIFYETSALIPAIAHTAARAGGQATELLGDGLLILFHIERGKREQVIARACAAAARCIDSSIACVNDLLWQRHRLPPLKIGIGLAYGPAIVKVVDANGCHPKVIGQCIWDATKLSGGENAIGLSRPLQDFLRAKGFNERFEVIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JL4</accession>
    <name>Q63JL4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111708.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1703"/>
    <dbReference type="EnsemblBacteria" id="CAH39176">
        <property type="protein sequence ID" value="CAH39176"/>
        <property type="gene ID" value="BPSS1703"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1703"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6005"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MELDHEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="39865" checksum="6C048DE3E5531FE7" modified="2004-10-25" version="1">MLALAGASAAYAAPDAASAASAEQAAPLTITVRPGQSLNDIAVAVTQSHDPGVLARAGRALFDANPQAFMKRDPSRLKIGAQLMVPALDATGGAAASGATAASAAASAASAASAASAASAASTSAVTGAAPHPSASASAPAAASRPAAASGATHAATASGAAAFAASGVAAGSASGANGASAPGVSAPGAASAHAPSAVAPAAPVASSGAGSAHVWSGSIQQAPAGANGASAAGAEALLAPGAANRAPSGSGAQAAGASQARPSSLQQLLALKNRVLMELQKHGIGKPAANVAPAPAAGSAQKPQASAAAGAAASATAAATTASETIASDAAAGSAASATPASAAPAASMPAAAPSVSAPAHAAAPQAPFNTGAAVAIGAALAALIVGFALRRRKKGASADAIEPGAFTPAPALDPDAAAAIADAPAGPEAAEDARHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT4</accession>
    <name>Q63JT4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940891.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111638.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39105">
        <property type="protein sequence ID" value="CAH39105"/>
        <property type="gene ID" value="BPSS1630"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1630"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5017"/>
    <dbReference type="eggNOG" id="ENOG5033WMZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VERFEHP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="588" mass="62857" checksum="B0D77A57162AB563" modified="2004-10-25" version="1">MLKSVQHPTQPSTVSGPNRSASTQATGSPQQRPRRSLGAFSQGQLRSARETANRTRHDETPRLPPLSFGEPLSLDQIVARPPITGTSASTNGAALAAPDVIEPADARSLPSPSSQSSPPSSPPPSRPPSRPSSAAPPPIAPPLPPAADDFRAPLPERQPGQAYDRSKPGFTLAEANGIRPLAPLFNATAAHHHGEVAAGLAIGGLASGLAHETAGAGMNGHALFASWRKRRRYDRQLSAMRDRDVAAFSGAAIGGDARRLDRLILTRDRNGKLDYDLDKVMKLAANDDPLLAAQSAHAKDVLLTLYIRHEVAGKRMSRAAYELARNALGIASGAALIAGTQGLAAAPASAAAVAAKQAGFALALLNALDVGKGVRGLKQRMRNDKARDIDRSALRSRMTLDTRGIDDETPDEAIKGVHAVLKDNGRIEADRKRFGKLFPGRWIDEKKSTTNKNDMADLTARHALTLVERSIARFAGEGDANLHAFHARVHPRNASTSQQKRALRDAIERDAHLVDAYNLMRDLGMRGGEARIAIDGLIARRIEIGLANDPATSRARATDAGRKHAEQQRSGERAPDDVTAMRTVLQRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JZ3</accession>
    <name>TAUB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Taurine import ATP-binding protein TauB</fullName>
            <ecNumber evidence="1">7.6.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tauB</name>
        <name type="ordered locus">BPSS1573</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)</text>
            <dbReference type="Rhea" id="RHEA:14613"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="7.6.2.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (TauB), two transmembrane proteins (TauC) and a solute-binding protein (TauA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536558.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111579.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63JZ3"/>
    <dbReference type="SMR" id="Q63JZ3"/>
    <dbReference type="STRING" id="272560.BPSS1573"/>
    <dbReference type="EnsemblBacteria" id="CAH39046">
        <property type="protein sequence ID" value="CAH39046"/>
        <property type="gene ID" value="BPSS1573"/>
    </dbReference>
    <dbReference type="GeneID" id="56530017"/>
    <dbReference type="KEGG" id="bps:BPSS1573"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4945"/>
    <dbReference type="eggNOG" id="COG4525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AFIETRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015859">
        <property type="entry name" value="ABC_transpr_TauB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788:SF18">
        <property type="entry name" value="PTHR42788:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51250">
        <property type="entry name" value="TAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000093005" description="Taurine import ATP-binding protein TauB">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01714"/>
        </source>
    </evidence>
    <sequence length="260" mass="28074" checksum="B5E66480159A70A5" modified="2004-10-25" version="1">MAKLCAQQVSVVYASRRGALTALENVSMSVGSGEIVVALGASGCGKSTLLSLLAGFQPPTSGRVSVDGVPVAGPGADRGVVFQDDALMPWLNVIENVAFGLRMQGVGRDARHARARDVLRLVKLAGFEQHRIDEISGGMRQRVGLARALAADPSFLLMDEPLGALDALTREHMQTLLLDVWRATGKGVFLITHSVEEAVLLATELLILSPRPGRIVARHALDFARRYAHGEPVRSIKSDPRFTEIHLALVEQLMRETEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KC4</accession>
    <name>Q63KC4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205614.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111448.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1438"/>
    <dbReference type="EnsemblBacteria" id="CAH38911">
        <property type="protein sequence ID" value="CAH38911"/>
        <property type="gene ID" value="BPSS1438"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1438"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5676"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VNPHWVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="598" mass="64900" checksum="43B4B7D15BD15278" modified="2004-10-25" version="1">MSVHSDRFAAIQMQLKQGDLIAAADAIDAWRAAEPASADALACRAHWLRLLGRFDEAAAALEPALAATPPCAAAWAERARLDRLAGQAERAHAAFDAAHRADPAATAWLAEWIELLHPLHHPALALPVAQALCEHAPDSAQSWFLLGLTHHYAGDYAAAAAAYRRADALDPAYPMLRNNLAALRYQTGMTAEALALAEAAIRAEPDNQMAWCNCSNAWLALREPARALIAGERACALGPNYAIAQLARANALKELQRWPDALAAAAHAHRSAPDDPVMQWSLAMLQLLHGDYANGWANHEARWNGSRELGDRPRPSPQQQWRGEPLAGKTLMLWGEQGFGDALQFARFAPIIAEQATRAGAQVVFACFAGLEPLFARSFAGAPMRIVRHDAPQLPAFDHHLPVGSAPLLLGVRPDTIPAAGGYLRADPARAAQWAARRPADGRLRVGLVWSGSRTHQRNPLRAIDPAACARAWRDLTGVAFHSLQIDGAADVATMRAAGLDVIDHTAELPSFDDTAAYLSSLDLVVTVCTSVAHLAGALGRPTRLLLDVNPHWVWMIDREDSPWYGSLRLYRQPRYRDWTTVLDRVRDELAALAAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KF9</accession>
    <name>Q63KF9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative type III secretion-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sctV</name>
        <name evidence="12" type="ordered locus">BPSS1401</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528711.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111413.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1401"/>
    <dbReference type="EnsemblBacteria" id="CAH38876">
        <property type="protein sequence ID" value="CAH38876"/>
        <property type="gene ID" value="BPSS1401"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1401"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4725"/>
    <dbReference type="eggNOG" id="COG4789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECGHLPP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006302">
        <property type="entry name" value="T3SS_HrcV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01399">
        <property type="entry name" value="hrcV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="705" mass="75866" checksum="F5BF3EE67C1F9D4A" modified="2004-10-25" version="1">MFKSLKLPAGGEIGIVALVIAIISLMILPLPPVAIDLLLGINITISVTLLMVTMYVPDIAALSAFPSLLLFTTLFRLSLNIASTKSILLHAEAGNIIESFGQLVVGGNLVVGLVVFAIITTVQFIVIAKGSERVAEVGARFTLDALPGKQMSIDADLRSGLLSTEEARKKRATLAVESQLHGGMDGAMKFVKGDAIAGLIITMINIVAGIAVGVAYHGMSAGDAANRFSVLSVGDAMVSQIPSLLLSVAAGVMITRVTDERAPKRRSLGDEISHQLGSSARALYFAAFLLLGFAAVPGFPAALFVLLAAALAFAGYRLSRKGSPSSGAARGQEQEALRAMQRSGAKADVPPILPRAPQFACAVGVRIAPDLASGLALPRLDEALDLERARLQDELGLPFPGVTMWIHPTLSAATFEVLIHDVPHLSVTLPARKAMLPQQRHLSPAHAALTDEQKARHRDLIERSEAGPPIDASGQATHWIDEPAVTAKDSVWRAEQIIAYASVAAIRTHAPLFVGIQEVQWILDQLGADSPGLVAEVLKILPSTRIADVLRRLLEEQISIRNVRTIMESLVAWGAKEKDMLMLTEYVRGDLSRFLAHRAAQGERVLSAVLFDLQAEQHIRQAIKQTPTGNFLALPPDDASRLVDRIQSLVGANARTDIALVTSMDIRRYVRRMIERRIDWLAVYSYQELGEHVELRPVGRVSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KL1</accession>
    <name>Q63KL1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative efflux/sugar transport/multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1350"/>
    <dbReference type="EnsemblBacteria" id="CAH38821">
        <property type="protein sequence ID" value="CAH38821"/>
        <property type="gene ID" value="BPSS1350"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1350"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4654"/>
    <dbReference type="eggNOG" id="COG2814">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EmrB-like"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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            <end position="239"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="375"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="439"/>
        </location>
    </feature>
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        <location>
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            <end position="516"/>
        </location>
    </feature>
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        <location>
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            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAH38821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="528" mass="56241" checksum="6A99D31474BE09AA" modified="2004-10-25" version="1">MSAPARPAAAAANGAGAREPAAARPLRGAKLALLTFALSLATFIEVLDSTVANVAVPAISGSLGVSNSQGTWVISSYSVAAAIAVPLTGWLARRVGEQRLFVASVILFTLTSLLCGLARDLEVLVACRALQGLFSGPMVPLSQTILMRAFPPAKRTFALALWGMTVLLAPIFGPVVGGWLIDNFSWPWIFLINLPIGLFSFAVCTLMLRPRASRGEASPIDVPGIVLLVIGVGSLQAMLDLGHDRGWFDSSLITALAIAAGVSLVSLLIWELGEAHPVVELSLFRERTFTFCVVIISLGMMSFSVVGVVFPLWLQAVMGYTAYQAGLATASMGLLALVFSILVGVYASRVDARVLVTFGFGVFAAVMGWSTHFTLSMTFAQVVTPRLIQGMGLPCFFIPLTAATLSRVADDKLAAASSLSNFLRTLSAAFGTALSVTWWDNRATYHYAVVSQAVTRASENTQRYVDALHAMGLHGARELSSLHQVVRQQAYMMATNDMFYMASVTCVLLAGLMWLTRPKRGAAATMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KM2</accession>
    <name>Q63KM2_BURPS</name>
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        <submittedName>
            <fullName evidence="2">ArsR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111349.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1339"/>
    <dbReference type="EnsemblBacteria" id="CAH38810">
        <property type="protein sequence ID" value="CAH38810"/>
        <property type="gene ID" value="BPSS1339"/>
    </dbReference>
    <dbReference type="GeneID" id="56597542"/>
    <dbReference type="KEGG" id="bps:BPSS1339"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4639"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CILANEE"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
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        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="115" mass="12593" checksum="45F4FD7D9D3FAD34" modified="2004-10-25" version="1">MSAACSPIDLSGMRASADAACALLKVLSNPDRLLMMCELAQCGELCVSDIEARLDIHQPTLSQQLGVLREHALVDTRRDGKNIYYALTSEPAVAIMAVLYEQFCATHQKGKRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KT7</accession>
    <name>Q63KT7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cobalt-nickel-resistance system transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnrT</name>
        <name evidence="4" type="ordered locus">BPSS1277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111284.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1277"/>
    <dbReference type="EnsemblBacteria" id="CAH38744">
        <property type="protein sequence ID" value="CAH38744"/>
        <property type="gene ID" value="BPSS1277"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1277"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5473"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EPHSHWH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="161"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="37027" checksum="3A8B5B5F4D10A6B6" modified="2004-10-25" version="1">MPMSTRTNAAFTALLAAALFGATTPLAKTLLGSLTPFMVAGLFYLGSGVGLGAFMLMRRLAGGAGASPVGHARLPLAELPWLAGAVAAGGVAGPALLMLGLATTPAATSALLLNLEGAFTALIAWAVFRENVDAQIFAGMAAIVAGGVLLSWHPGAAGVPLGALLVAAACACWAIDNNLTRKVSTHDAAAIACVKGLVAGTVNLGIALALGARLPAAADSAAAMLTGFAGYGVSLVLFVVALRNLGTARTGAYFSVAPLFGVGLSLALWPEWPPLSFWAAAALMALGIWLHLRERHEHPHTHEALEHSHRHRHDTHHQHAHDFDWDGTEPHTHAHRHTPITHTHAHFPDIHHRHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KU5</accession>
    <name>Q63KU5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative peptide synthase/polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205578.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111276.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1269"/>
    <dbReference type="ESTHER" id="burma-q62c00">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38736">
        <property type="protein sequence ID" value="CAH38736"/>
        <property type="gene ID" value="BPSS1269"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1269"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4539"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHEAHEA"/>
    <dbReference type="PHI-base" id="PHI:7014"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2109"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3852"/>
            <end position="3927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1057"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="2144"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="3887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="4236" mass="454933" checksum="93391AB45B5C4A95" modified="2004-10-25" version="1">[encoded data, 4236 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KV3</accession>
    <name>Q63KV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198082.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111268.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1261"/>
    <dbReference type="EnsemblBacteria" id="CAH38728">
        <property type="protein sequence ID" value="CAH38728"/>
        <property type="gene ID" value="BPSS1261"/>
    </dbReference>
    <dbReference type="GeneID" id="56597481"/>
    <dbReference type="KEGG" id="bps:BPSS1261"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4531"/>
    <dbReference type="eggNOG" id="COG4390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WFAEHVE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016755">
        <property type="entry name" value="UCP019302"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10084">
        <property type="entry name" value="DUF2322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019302">
        <property type="entry name" value="UCP019302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="110" mass="11507" checksum="D6631D9887DA513C" modified="2004-10-25" version="1">MIQPTEVFKDNLAQLPAIDGIERIDLVDGGGAVVASIENKPGKQGSLAVYHYLREAFGTLDAQAAAHGLAVFAEHTADARNRPGAHPNVDRLLAIAAGGEALRIDVLARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KW8</accession>
    <name>Q63KW8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS1245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198742.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111253.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1245"/>
    <dbReference type="EnsemblBacteria" id="CAH38712">
        <property type="protein sequence ID" value="CAH38712"/>
        <property type="gene ID" value="BPSS1245"/>
    </dbReference>
    <dbReference type="GeneID" id="56597464"/>
    <dbReference type="KEGG" id="bps:BPSS1245"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4501"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRPEQEE"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="28187" checksum="DF6400E0B6891A34" modified="2004-10-25" version="1">MNTMGKVTLLGAGPGDLDLLTMKAAKALAAADVLLLDDLVDPGIVALAPRARVIRVGKRGGCRSTPQAFIERLMCRYALRGAHVVRVKGGDVLLFGRAGEELAALRAARVPVEIVNGISSGFAAAASLGVSLTHRDHCQGVTFVTAHLQDHGEPDWASLAATGTTLAIYMGMSRIERIAAGLLSTLDDKTPAAVVQWAGAPAERRWTGTLGHLASGAAEAGLGSPAVIFVGRAIGEALAIGDAHAAPHANAHALADDAHAALHAAERRRISHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KX9</accession>
    <name>Q63KX9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543285.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111242.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1234"/>
    <dbReference type="EnsemblBacteria" id="CAH38701">
        <property type="protein sequence ID" value="CAH38701"/>
        <property type="gene ID" value="BPSS1234"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1234"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4483"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YIPFLYM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="270" mass="28930" checksum="E8DB3A39CF4DDD26" modified="2004-10-25" version="1">MGRLIARGGTVAIGGAIALVAVFPLAWALLNSFKRLLDIVTPTPRFIFTPTLDNYRQVLSSPEVLIGLGNSVAIVGVAVALGAALGVPAAYAIARYPVRGKRDIQFFLLSLRFLPPVAVAIPLIAIWVDLGLYDTKLSMIVTYLLVTLSTITWLSIPVFRRLPREIEEAAALDGYGPYAVFWRVALPVCASTLLGGIVFSFVLVWNELMIALALTSSRAATLPVVASAFTSLGQEVPWGVINASTVLLALPPLVFVGMLSRLLNSMLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KZ8</accession>
    <name>Q63KZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528502.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111223.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1215"/>
    <dbReference type="EnsemblBacteria" id="CAH38682">
        <property type="protein sequence ID" value="CAH38682"/>
        <property type="gene ID" value="BPSS1215"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1215"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4454"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYPQIGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="426" mass="46621" checksum="38C9BFB883C54908" modified="2004-10-25" version="1">MRSKSGQTLKIALTANLFEWYEFSLTAFMALEIGRLFFPDTNEKTALISSFSVFASSYLARPIGSILFGILGARYGTGASLKISMIGMAVPASLIAVLPTYQTAGHFSTFLLLALKITQGFCAGGEMPLSGYFVSLNADRTNRGLYCALTVASGFIGMLLASAAVFLLPHIRYALDHLASPENYAYLNEPWRWPFFLCMPLSISIYLLRSAINKSEVKVDSGKLRAKPTFPLLQSLAVVAFAEIVIYIIFVWMPNYLHVYLGKQSFDARLSNISSLIIFSISMACAGYAERYFCARNIALFGTIATAISVYPSFIIMQYGGIFALLFSQAILAISAGCVVGVIFVVLPDLFKKNWGSLGMVVTYSFATAIFGGTAPVFCAYLIELTHFIAAPAIYIFLMGMLAAAAIYKIYPPSKTKFRYRAPNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L85</accession>
    <name>Q63L85_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539150.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111136.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1123"/>
    <dbReference type="EnsemblBacteria" id="CAH38591">
        <property type="protein sequence ID" value="CAH38591"/>
        <property type="gene ID" value="BPSS1123"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1123"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4341"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LHYLVMT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="26333" checksum="7AED38C27FE6607D" modified="2004-10-25" version="1">MSAAEPHYIDAQRTIAPVDAPLAAPHEYAAVLRSDFVSSYHDGRDVWTDEAAMRPASAILHAHLGRPAEVLDAGAGRGRDTAYFLEQGHRVTAVDLVEPPEWAQLAQRWGERVRFVARPVSELDGEARFDGALDNGCLHHQHPDAYRAYLARIHALLRPDGRFTISVFESDGPGRLYANHAQRLYREFTEPELAELLRAAHFTPVDSQRVPRPKAGLHYLVMTARKTDSTDASARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LB9</accession>
    <name>Q63LB9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage late control gene D protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009971808.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111102.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1089"/>
    <dbReference type="EnsemblBacteria" id="CAH38557">
        <property type="protein sequence ID" value="CAH38557"/>
        <property type="gene ID" value="BPSS1089"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1089"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4288"/>
    <dbReference type="eggNOG" id="COG3500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TDRHRSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="40708" checksum="A766E993312A2129" modified="2004-10-25" version="1">MATPTNERTTRAELQDAPRVARLHPQPDYRISVGGRDLSRLFAPRLVSLSISESRSDEADTIDIVLDDSKNDLDIPKRGATIKASIGWAGEPLVDKGSFVVNEVEHSGAPDIITIRARSAAMTSGMQERREKSWHRQTIGSIVHAIAGRYSLAPIVGDALARILIAHIDQTHESDMSFLTRLAKRYDAVMNVKDLRLLFMPIGTGQTASGKQLDVLELTRASGDSHRYHVSERENYAAVRAHYHSTGRAKRKSVIVGGENNKNVKVLPEDYATEAEARAAAQAEFKRMQRSQATMSYTLARGRAELFPEMPVTVSGFKPEIDETPWLVKKTTHTIGDVGFTTALELEMRDDPTTERHRSHFRRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LE7</accession>
    <name>Q63LE7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage terminase, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111074.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1063"/>
    <dbReference type="EnsemblBacteria" id="CAH38529">
        <property type="protein sequence ID" value="CAH38529"/>
        <property type="gene ID" value="BPSS1063"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1063"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5199"/>
    <dbReference type="eggNOG" id="COG4373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDEFFWT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010332">
        <property type="entry name" value="ATPase_terminase-su_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035421">
        <property type="entry name" value="Terminase_6C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06056">
        <property type="entry name" value="Terminase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17289">
        <property type="entry name" value="Terminase_6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_6C" evidence="2">
        <location>
            <begin position="425"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="601" mass="68412" checksum="17BD2596A71D25D3" modified="2004-10-25" version="1">MLARTRRPTLGRMLETTDPHQLENDVRKVARTLYWQGWRIASIARHLDIKPATVASWCRRERWKDATPVERIEASLEVRLMVLIAKEKKDGADYKEIDLLGRQVERLARVRKYDETGKESDLNPKIASRNAGPKRRAPRNEISDEQHQRIIEAFRDSLFDYQKVWYRNGDQRTRNILKSRQIGATWYFAREALVDALDTDRNQIFLSASKAQAHVFKQYITQFARGAADIELTGDPIILPSGATLYFLGTNARTAQSYHGNFYFDEYFWVPKFRELNKVASGMAMHKRWRKTYFSTPSSVTHEAYAFWSGAHANRGRAAADRIQIDTSHEALVRGMLCEDAQWRQIVTVLDAMAGGCDLFDIDELRREYSAEEFANLLMCQFIDDSLSVFKLSDLQRCMVDSWEEWADDFSPLLLRPFGYREVWVGYDPALTGDSAGLVVVAPPRVDDGAFRVLERHQFRGNDFEEQAAAIEAITQRYNVGYIAIDTTGMGQGVYQLVRKFFPAAVALNYSPEVKTRLVLKGQSVVRNGRLQFDAGWTDLAAAFMAIKQTMTASGRQATYTAGRTDETGHADLAWACLHAIDREPLAGGGIHSSSFTEFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LM5</accession>
    <name>Q63LM5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110996.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0988"/>
    <dbReference type="EnsemblBacteria" id="CAH38450">
        <property type="protein sequence ID" value="CAH38450"/>
        <property type="gene ID" value="BPSS0988"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0988"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5112"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVVNIPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="225"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="425" mass="43729" checksum="72FDF58A27AFE861" modified="2004-10-25" version="1">MPIDSERGTTMNRLPIAFRRLALSNLAAQSAEQIGLAVAPLVAVLSLGASASGTGLLQTAQTLPFLLLSIPLGVWADRHSRKRIMAAAEGLRALALAATLALLAAHALTLPSLAMLGFVGACGTVAYSVAAPALIPALVGRAALARANGAIELARSAAYSAGPAIGAALVDRIGAQWAYGFAAALSAHAVLLIVRLPDVRAPAAPRKRFVAELLDGARFVRRDRHLRLMIVTAVFFNVGFFTLQAVYVPYAVRHLALGASQIGMTFAAYGIGMTGGAALASAIARRVRFGVVLTIGPVGGLVASLVMAVSIFAPSFWLAASSFFLLGAGPILWSVASTTLRQAITPPAMLGRVCAINGTATYGARPLGALVGAVVAARFGIDACIWASVGGFVIQAAVIVRSAVSRLERIPDVSDAAPRYAPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LQ4</accession>
    <name>Q63LQ4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524054.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110967.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0959"/>
    <dbReference type="EnsemblBacteria" id="CAH38421">
        <property type="protein sequence ID" value="CAH38421"/>
        <property type="gene ID" value="BPSS0959"/>
    </dbReference>
    <dbReference type="GeneID" id="56530585"/>
    <dbReference type="KEGG" id="bps:BPSS0959"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7273"/>
    <dbReference type="eggNOG" id="COG5435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QFAEREM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014894">
        <property type="entry name" value="DcrB/EagT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08786">
        <property type="entry name" value="DcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="SSF55724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="146" mass="16196" checksum="D31C809B3BCAEF4B" modified="2004-10-25" version="1">MRYSVNEGHLELPGQWLDRSVNALLPAMAEVTGSNLVLTRDELPYGVEFADYVDVQRAKYRKELSGLQMQRDEPGVLDGRPCQFLAFTWNKDDLLIHQMAVIVLDAPLVLALTYTSPGRLPDGVRDAIGAALASFRFHRGAQLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LZ3</accession>
    <name>Q63LZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523978.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110878.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0869"/>
    <dbReference type="EnsemblBacteria" id="CAH38331">
        <property type="protein sequence ID" value="CAH38331"/>
        <property type="gene ID" value="BPSS0869"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0869"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7159"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RGHVHVF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="449" mass="49109" checksum="0A430FB0026FC97C" modified="2004-10-25" version="1">MSYNDSRFWHPMLHPNDMKRREPIRIVRGDGCHVYDERGRQLVDGVAGLWNVNVGHNRAEVKEAIVRQLDELEYFQLFDGITHPRAEELSSKLIDMMEPEGMRRVLYSSGGSDSVETALKIARQYWKVRGQADRTKFISLKQGYHGTHFGGASVNGNTVFRRNYEPNLPGCFHVETPWLYRNPFTQDPEALGRICAELLEREILFQSPDTVAAFIAEPIQGAGGVIVPPANYWPLVREVCDRYGVLLIADEVVTGFGRSGSLFGSRGWGVKPDIMCLAKGISSGYVPLGATAVNARIEDAFAANADFGGAIMHGYTYSGHPVACAAALASLDIVLREDLPANAAKQGAHLIEALRPFVERFDALGEVRGKGLMVALDLVADKATRAPIDPMSGYANAVAEVARENGVLVRPVGTKIILSPPLVIQREQIDRIVAGLEAGFAATPFPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M23</accession>
    <name>Q63M23_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110848.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0837"/>
    <dbReference type="EnsemblBacteria" id="CAH38299">
        <property type="protein sequence ID" value="CAH38299"/>
        <property type="gene ID" value="BPSS0837"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0837"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4928"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ACKREGV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="155"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="279" mass="29963" checksum="A8F4DFD7F577D737" modified="2004-10-25" version="1">MMKFKTLLVHVDDSRQSGARTEFALDLARRWDAHVIGLYVVCQDLMRPLFRRDESLRLAANEAQHAARRDAAQARFTAAGERAGVNFEWRAPAGPPTDVATLHARHADLVVLGQPEPGDAAAYIEPHFVDDVVMSGGVPAIVLPFTGAMRTFGENVLLAWDGSREAARAVADALPLLKRARFVTVESVLRRRATGAGLAPAGIDVAAYLGRHGIQASFSASAHVPGVDTGAALLNRAADLHADLLVMGAYGHTRARERVLGGVTRTMLESMTVPVLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M56</accession>
    <name>Q63M56_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551535.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110815.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0805"/>
    <dbReference type="EnsemblBacteria" id="CAH38266">
        <property type="protein sequence ID" value="CAH38266"/>
        <property type="gene ID" value="BPSS0805"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0805"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7068"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CRQMRQW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="4">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="287"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="429"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="688" mass="74358" checksum="FE370EE2C9C7FF6C" modified="2004-10-25" version="1">MHGTYNLWLVALSLAVATLASYTALDLSGRIALLAHGRLRHAWLAGSAVAMGIGIGSMHVIGVLSVTLPIRIGFDAAITGLSLALAIVVSGFALYTIAGAQLTRLRLGIGGVLMGLGIAGMHYTGDAAMRMKPAIEYDPLLFTASIVIALVASTVALWIAQTLIGIGRSRLARIGAAGVMGAAITGMHYTAYAAAIFAPGSTCGAATGIDLRWLAATVALFTVAILIVALILSHFDVRTTLLAGSVSRLSGQIVRMAAFDTLTDLPNRHTLNEHLGRALAAARARGGKLAILFMDLDGFKTINDSLGHPAGDEVLKTFSQRLLRCVRDGDIVARLGGDEFVVLLESVSSDDEAARVARNVLERMRKGRWNDGQALQVTPSIGIALYPKDGDTADTLLRHADAAMYAAKRSGRCTYRFFEATMDEAAARALKLQHALHEALDSDYFSLCFQPKFRCDGHRLAGAEALLRLNHPTLGKLAPMEFIPVAERSGQIIEIGYWVIRETCRHLRRWRSAHRAACRIAINLSPRQLAQPDLVANILEIVRAEHVEPRQLMFEITESVAMEDPPRTIEMIRLFQAHGFEIAIDDFGTGYSSLAYLQRFGAKQLKIDRFFTHALDEQGHEGGAIVSAIIALAHSLAMDVVAEGVETRSQLDRLKTLMCDEIQGFLLGRPVPPEEFEAMVPLHSEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M80</accession>
    <name>Q63M80_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0782"/>
    <dbReference type="EnsemblBacteria" id="CAH38242">
        <property type="protein sequence ID" value="CAH38242"/>
        <property type="gene ID" value="BPSS0782"/>
    </dbReference>
    <dbReference type="GeneID" id="56530766"/>
    <dbReference type="KEGG" id="bps:BPSS0782"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7034"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SAGDTEW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="401" mass="40157" checksum="73A1819C10D784C7" modified="2004-10-25" version="1">MDITVTEKRGVATTLALCFAIALLEGLDLQSVGVAAPRMAREFGLSVAQMGWAFGAGTFGLLPGALLGGRLADRIGRKRVLIVSVCTFGLLSIATAQASSFAMLVVVRVLTGVGLGGAMPNLIALSSEAVEPRLRGSAVSAMYCGIPFGGVIASAIGVLLVGDAQWRHIFYVGGLGPLLLVPLLARCLPESRAYLDAARMGGARPAARAALFGGGRACATLALWVSYFCTLIVLYFLLNWLPSLMAARGLGRAAVGAVQIGFNVGGGLGALGIGMLSDRLGASRVVGAMYAGIVASLVALALAPGFAGLAAAAFAAGMFVIGGQSVLYALAASHYPAAMRGTGVGAAVAAGRIGSVVGPLAAAQLLAMGRSGAVVIGASIPVTLLAAAAALLLVRRPPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MF8</accession>
    <name>Q63MF8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AraC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546577.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110713.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38159">
        <property type="protein sequence ID" value="CAH38159"/>
        <property type="gene ID" value="BPSS0699"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0699"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6913"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HARGQLF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="30406" checksum="73C8C24A1C96DC11" modified="2004-10-25" version="1">MLDPILPIELVTSSEGPFVAAVELTQRTERTTARHSHARGQLVGASSGLVSIGLDDEDWVVPAIHAVWIPPHRVHSLRSFGPFAGWSVFVAEDRCAALPGAPRAIVMSTLLREAVRRAASWRGAALDAARARIANVILDEIAAAQTGPRGLPRPRDPRLRRIADALAGNLADNRRADEWAAWAGMAPRTLSRRFVSETGFTFTQWRQQARVLRALERLADGVTVTAVALDLGYDNVSAFIDMFRRTLGTTPGQYVNARAGDARDGAPAPCGPRAVRARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MQ5</accession>
    <name>Q63MQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2Fe-2S iron-sulfur</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523182.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110616.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0595"/>
    <dbReference type="EnsemblBacteria" id="CAH38052">
        <property type="protein sequence ID" value="CAH38052"/>
        <property type="gene ID" value="BPSS0595"/>
    </dbReference>
    <dbReference type="GeneID" id="56530953"/>
    <dbReference type="KEGG" id="bps:BPSS0595"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4621"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIEWPGL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="10417" checksum="6A9BC52DBC5561BE" modified="2004-10-25" version="1">MTEERSHWVRVEPLGAGFDAPESLSLLEAAGFAGVSLPRSCRNGTCRTCLCRLREGSVAYRIEWPGVSAEEKAEGYILPCVAIAQSDLVIEVPHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR2</accession>
    <name>Q63MR2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyochelin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pchF</name>
        <name evidence="7" type="ordered locus">BPSS0587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205430.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110608.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0587"/>
    <dbReference type="ESTHER" id="burps-q63mr2">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38044">
        <property type="protein sequence ID" value="CAH38044"/>
        <property type="gene ID" value="BPSS0587"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0587"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6763"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVACHGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041464">
        <property type="entry name" value="TubC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18563">
        <property type="entry name" value="TubC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1586"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="2015" mass="217151" checksum="0B3BF7409EE9D988" modified="2004-10-25" version="1">MSFEDVLETCRERQIELWCDGEQLRYRAPAGALDAPLAARINAQRAAFVRFLRDGAWRAQPSRTHERFALTPVQAAYVLGRHAAFEFGGSACHLYVEYRESADLDVRRFEAAWNACVARHPMLRAIVEDNAWQRILPDVPWQTLAVHDLRDANAAAFDAHVRRVRERLDHAVHALDRWPVLQPEVSIGPDGAVLHLSVDFTLIDYASLQLLLAEWRRRHDDPQWKPAPLDVTFRDYVVNEARAGRRAQHARDAAWWLARIDGLPGRPDLPVLPRPPEGRADARPRFTHRHARLDRARWDVLVAFASRFGLSPAGVALAAFAEVVGRWSQSPAFCLNLTVLNRPPVHPQIDAVLGDFTALSLLAVDVAQGSDFAARARAIGAQMFDDLDHRAFTGVEVMRELARRRGKDAALMPVVFTSGIGSVGRLLGEHGEHGARAAPPCYMISQTPQVWLDCQVTDQFGGLEIGWDVRDDLFPAGMPAAMFDAYVALLARLASDAAWWARPGDIVLPSGPPVACAHPDADRHLAAGFAAQARRTPDATVVIDAAGAHTYRDVAQRAAAVRAALERAGVAPGDKVAVRMPKGANQLVAVLGIVQAGAAYVPIDYRQPALRRRAILRNAQVGAIVTERALDGEPDGCARIDVDALAPDPRWPPRDAHPLEGDALAYVIYTSGSTGEPKGVMVSHAAVCNTLADINARHAVGAGDAVLGLAELSFDLSVYDLFGATARGARVVLPDPARGNDPSHWAELIARHGVTLWNSVPAQGQMLIDYLESEPARAMPGPRCVMWSGDWIPVSLPTRWWRRWPDSRLFSLGGATEASIWSIEHPIRPEDTRLVSIPYGRALTGQTVDVLDALGRPCPPGVRGEIHIGGVGLATGYANDPARTAERFVRHADGRRLYRTGDLGRRRADGSLEFLGRQDDQVKIRGYRIELAEIDAALSAHPRVASAATIVLGDAAQRRLASFVTLHGAAPDPRRRDAQLHAIAQRVRDALAAERWPARAEIRRSVGQLDAACVASLASWIVRAGGLTRDASVDFATLAERLRVPAARHGLLRHWLALLEARGVLCTDTAGPVAGVDVTESENSAASRGAADADAFEAFEAFEAFEAFEAFEVFEAFEAPEAPEAPEAPEAPEAPEAPEAPEAPEAPEAPEAPEATEATEATEATEAPEAPEATEATEAIETIETIETIETIETIETIETIETPNAADVTKATKSAGTTDTTTSPAGWRVARAHAARATDAAGAVPLSDADACWDAFARDASPALWPAVLIDYFRASAACLGEQVDDRVSPAGLMFPQGAPHVAEAMYSDGMHARALHRAMAEAVSGIVAREPRRAWRILEIGAGTAAATRAIVDALAPHAESGVRIDYLFSDVSSYFLAAARERFAAYPWVRFIRFDMNAPLDAQGVAPHSVDLIASSGALNNARDTVALVAGLRALSSADAWWVIQELTAEHPEISISQGLMMEPPRDARAASHRLFVHRAQWLEWLRAAGDRALGCVEPDSPLDALGYDILLARVKADAARVDADELLAFAAERVPRYMVPSQLCALERLPVTANGKIDRRALAQIAGVHEPRAAHGRAVRACDAEPLLARLIGLWEAVLDTQGVAADQDFFAAGGDSLLIAQLVSRVRAEEPLARAHPFDRLLRWALAQPTPAGLAQCLRDAKAQAQSSTAAPSRTATATATATATATATATAATAAARAAPAASIVHAPAPRGRIDVRPLRLAPGVGVPRVVVHEGLGTVHAYRPIVPALARLGPVLGFAVRDAQDYLDLPAQHLSATLGARYAYALSREGIGEVDVLGYCSGGLIALEMAKTLVQLGVAVRSLDIVSSYRIPYLIEDERLVLFNFAATLGLPLDALGFPAAHLLADALADALKADPARVAPGSIQAQLEAFGDRCAPLDILRRRVLRVSAGLPADGDEPHPLVDERERLYRLFMHSVHASHWAAHAPYAGPLRLFVPERCNPLIPQQRAALFDYWRDQALGGIALVDVPGGHFDCLTAAFVDTHLKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MS7</accession>
    <name>Q63MS7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543123.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110592.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0571"/>
    <dbReference type="EnsemblBacteria" id="CAH38028">
        <property type="protein sequence ID" value="CAH38028"/>
        <property type="gene ID" value="BPSS0571"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0571"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6740"/>
    <dbReference type="eggNOG" id="ENOG50316KB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GYKPGLS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025421">
        <property type="entry name" value="DUF4148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13663">
        <property type="entry name" value="DUF4148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266596" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="102" mass="10536" checksum="83BF450045F75211" modified="2004-10-25" version="1">MKSLVYAVVAASALTASFGAFAQSSQPLTRAQVRAELVQLEKAGYHPGVSSPYYPEDIQAAQARVQGADTSGYGAQAAPVAHVGAPVAAAPRSPRESIYFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MT1</accession>
    <name>Q63MT1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523151.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110588.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0567"/>
    <dbReference type="EnsemblBacteria" id="CAH38024">
        <property type="protein sequence ID" value="CAH38024"/>
        <property type="gene ID" value="BPSS0567"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0567"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6736"/>
    <dbReference type="eggNOG" id="COG3246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VPEYEIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="309" mass="33181" checksum="7698905300ACFA7E" modified="2004-10-25" version="1">MNQEVIVTCAVTGAGDTVGKHPAIPVTPKQIADAAIEAAKAGATVAHCHVRDPLTGRGSRDPRLYREVVDRIRSADVDVIINLTAGMGGDLEIGAGENPMRFGKGTDLVGGLTRLVHVEELLPEICTLDCGTLNFGDGDYIYVSTPAQLRAGAKRIQALGVKPELEIFDTGHLWFAKQLLKEGLLDDPPLFQLCLGIPWGAPADTGTMKAMVDNLPAGAHWAGFGIGRMQMPMLAQAMLLGGHVRVGLEDNLWLDRGVHATNGSLVERARQIVERLGARVLTPAEGRRKLGLPPRGERPLERRAMTEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB6</accession>
    <name>Q63NB6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205395.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110403.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37831">
        <property type="protein sequence ID" value="CAH37831"/>
        <property type="gene ID" value="BPSS0381"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0381"/>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IRIARVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="81" mass="9086" checksum="AD29D3496D7F76C9" modified="2004-10-25" version="1">MARVSGKLDKDGNLVLLGAAIRARRKELAMSQEVLADFVEIDRSHLGKIERGERNVTFMNIIRIARVMQLLPSELLRNAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NV0</accession>
    <name>Q63NV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196222.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110219.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0199"/>
    <dbReference type="EnsemblBacteria" id="CAH37644">
        <property type="protein sequence ID" value="CAH37644"/>
        <property type="gene ID" value="BPSS0199"/>
    </dbReference>
    <dbReference type="GeneID" id="56596950"/>
    <dbReference type="KEGG" id="bps:BPSS0199"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6267"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EPYIMLT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="304" mass="33964" checksum="D2FD58B15BFA2500" modified="2004-10-25" version="1">MALTLRQLKYFVATAELGQISQAAIQLTISQSAVTSAIRELEDSLGTQLFVRTASGVALTNTGRRFLNQAYTILSSVDEAMRIPNLESTLTGTLALAASYTVLGYFLPHHLMRLHTQYPRLTIQLHELNRESIEEGLIAGRYDMAVLLTSNVSNPELVLEPVIHSARRLWVGAHHPLLRRESVTFADVAPEPFVMLTVDEAAYTALRYWNETPYRPNVILRTSSVEAVRSMVANGSGVAILSDMVYRPWSLEGRRIETVLLRDPVPPMSVGLAWRRNAEFSPAMHAVREYFRHTFMEPRMGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NV7</accession>
    <name>Q63NV7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523532.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110212.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0192"/>
    <dbReference type="EnsemblBacteria" id="CAH37637">
        <property type="protein sequence ID" value="CAH37637"/>
        <property type="gene ID" value="BPSS0192"/>
    </dbReference>
    <dbReference type="GeneID" id="56531356"/>
    <dbReference type="KEGG" id="bps:BPSS0192"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6258"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NHIRGYG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="281" mass="31060" checksum="547F08A37ED142EA" modified="2004-10-25" version="1">MSNAPAPRTLTVPPLPPLTEAESADVTRRALALRAAFAQDVARRLNVPDAEQRAYGERLQQTLDANGLGELAREYVVLVDRAPNVQAVFLYFRTTRSNAWQMIGASPVATGLPGQYDHFVTPLGVFEHTPENMDFRAEGTTNDNGIRGYGQRDMRIYDFGWTDAERGWGKGGVSQMRFQMHATDPEYLEPLLGIRHSKGCVRIPASLNVFLDQHGILDAEYEARAAGGDPPWVLRAHRQVTPWAGRYLVVIDSQRKTRPAWSPAPGKKAQAKLPKGGDTAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P06</accession>
    <name>RBSA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose import ATP-binding protein RbsA</fullName>
            <ecNumber evidence="1">7.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbsA</name>
        <name type="ordered locus">BPSS0142</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29903"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523590.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110163.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63P06"/>
    <dbReference type="SMR" id="Q63P06"/>
    <dbReference type="STRING" id="272560.BPSS0142"/>
    <dbReference type="EnsemblBacteria" id="CAH37587">
        <property type="protein sequence ID" value="CAH37587"/>
        <property type="gene ID" value="BPSS0142"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0142"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6190"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIDHKAT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015611">
        <property type="term" value="F:ABC-type D-ribose transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51254">
        <property type="entry name" value="RBSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000261047" description="Ribose import ATP-binding protein RbsA">
        <location>
            <begin position="1"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="263"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01716"/>
        </source>
    </evidence>
    <sequence length="517" mass="55252" checksum="692DD818C0E8D6D4" modified="2004-10-25" version="1">MQRSDPPRPLLEMRGISKTFPAVRALAGVSLTVHPGEVHSLMGENGAGKSTLMKILSGAYQADPGGEILIDGRPISIDGPLAARDAGVAVIYQELCLAPNLSVAENIHVGRELRRGNGRRGTIDRAAMARGCQDVLERLGADFGPNTLVGTLSIAEQQLVEIARAVHTRARILVMDEPTTPLSSRETDNLFRLIRQLRAEGLAIIYISHRMAEIYELSDRVSVLRDGAYVGTLERDALSAERLVGMMVGRDISGFYKKAHAPYDPGNLLLSVRDIADGARVRGCSLDLHAGEVLGIAGLVGAGRTELARLIFGAEPRVRGEVTLAGKAFAAHSPREAIDAGLVYLTEDRKRQGLFLDMSVRENINISVCGRDARLGALDLARGAQRARDAIAALSIRVPHANVNVGALSGGNQQKVLLSRLLETKPRVLILDEPTRGVDIGAKSEIYRIINELARAGVGVIVISSELPEIIGVADRVLVMREGRIAGELGGRTDAPITQEAIIALATGSRTEASAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P16</accession>
    <name>Q63P16_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-08" db="PDB data bank">
            <title>Crystal structure of NTF2-like protein of unknown function (YP_110153.1) from BURKHOLDERIA PSEUDOMALLEI K96243 at 1.30 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523606.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110153.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="PDB" id="3EBT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.30 A"/>
        <property type="chains" value="A=1-131"/>
    </dbReference>
    <dbReference type="PDBsum" id="3EBT"/>
    <dbReference type="SMR" id="Q63P16"/>
    <dbReference type="STRING" id="272560.BPSS0132"/>
    <dbReference type="DNASU" id="3096484"/>
    <dbReference type="EnsemblBacteria" id="CAH37577">
        <property type="protein sequence ID" value="CAH37577"/>
        <property type="gene ID" value="BPSS0132"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0132"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6174"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IEWIIPG"/>
    <dbReference type="EvolutionaryTrace" id="Q63P16"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3EBT"/>
        </source>
    </evidence>
    <sequence length="131" mass="14808" checksum="83EF090384783DFA" modified="2004-10-25" version="1">MSNNMQTVRESYEAFHRRDLPGVLAALAPDVRWTHPDGMSPYGLGGTKHGHDEVIAFIRHVPTHIAEMRLAPDEFIESGERIVVLGTRRVTAVNGRSATLKFVHVWRFENGRAVTFEDHFDTAEMIRLITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P44</accession>
    <name>Q63P44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556024.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110125.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0102"/>
    <dbReference type="EnsemblBacteria" id="CAH37548">
        <property type="protein sequence ID" value="CAH37548"/>
        <property type="gene ID" value="BPSS0102"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0102"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6131"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAWYKYQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017733">
        <property type="entry name" value="OmpA/MotB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03350">
        <property type="entry name" value="type_VI_ompA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="315"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="433" mass="47721" checksum="FB7356FDBC94E848" modified="2004-10-25" version="1">MNSGAFDEAAFDFLVSDEGGANVAADRARSAAKAAGAEPARDRIDASVNVQHRLDEVRAAANPLLEAATPLLRMLADMPATLDTSEAVASLRTLLVREVALFQNLCEKADLPWKHMAVVRYCLCTALDEAANRTRWGGGGVWASQSLLITYEGEVDGGEKFFLLIGRMATDPQEYVDILEILYRVLGLGFEGRYSVVADGRRHLEQIRQRLWTLITGARDAIQPELSLRWRGAEPGRLPLLRSVPAWASGALVFLLLFGLFAFYQYRLLTERNALEARILAIAKDEPATPPQRLRLSILLKNEIARGLLTVDEDDRRSVVVFRGDAMFRSGESRVLPEIEPVLDKVAREVARVGGRVTVTGHSDNQPIRRADIPNNLVLSEKRAAYVAQILVQRGTPADRIRSEGRGDAQPVAENATPAGRSRNRRVEIAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PE0</accession>
    <name>Q63PE0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">kbl</name>
        <name evidence="3" type="ordered locus">BPSS0005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539575.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110029.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63PE0"/>
    <dbReference type="STRING" id="272560.BPSS0005"/>
    <dbReference type="EnsemblBacteria" id="CAH37448">
        <property type="protein sequence ID" value="CAH37448"/>
        <property type="gene ID" value="BPSS0005"/>
    </dbReference>
    <dbReference type="GeneID" id="56531550"/>
    <dbReference type="KEGG" id="bps:BPSS0005"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5999"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="399" mass="42947" checksum="8008670E0631A63A" modified="2004-10-25" version="1">MRDAYLAHLRGTLEQIRADGFYKTEREIASPQAADIRLAGGTHVLNFCANNYLGLADDSRLIAAAQAALEQDGFGMASVRFICGTQTVHKQLEAALSAFLKTDDCILYSSCFDANGGLFETLLDENDAIISDELNHASIIDGIRLSKARRFRYKNNDLADLEAKLREADAAGARFKLIATDGVFSMDGIIANLKGVCDLADRYGALVMVDDSHAVGFIGEHGRGTPEYCGVEGRVDIVTGTLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLTPSIAAASLKVLELLASDEGARLRERVRANGAHFREKMSAAGFALVPGEHPIIPVMLGDAQVASKMADALLAEGVYVIGFSFPVVPRGRARIRTQMSAAHTREQIDRAVDAFVRVGKTLGVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-08" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PG8</accession>
    <name>MNMG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">BPSL3408</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556009.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110001.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63PG8"/>
    <dbReference type="SMR" id="Q63PG8"/>
    <dbReference type="STRING" id="272560.BPSL3408"/>
    <dbReference type="EnsemblBacteria" id="CAH37420">
        <property type="protein sequence ID" value="CAH37420"/>
        <property type="gene ID" value="BPSL3408"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3408"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1781"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000117076" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="657" mass="71995" checksum="2187BF17E5A96F1B" modified="2004-10-25" version="1">MLYPTEFDVIVVGGGHAGTEAALASARMGAKTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDEGGIQFRILNSSKGPAVRATRAQADRVLYKQAIRRRLENQPNLWLFQQAVDDLMVEGDRVVGAVTQVGVRFRARAVVLTAGTFLDGKIHVGLNHYTGGRAGDPAAVSLSSRLKELNLPQGRLKTGTPPRIDGRTIDFSKLDEQPGDLDPIPVFSFLGRAEQHPQQLPCWVTHTNERTHDIIRSGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASKDSHQIFLEPEGLTTNEFYPNGISTSLPFDVQLALVHSMRGLEQAHILRPGYAIEYDYFDPRALKSSLETKAIGGLFFAGQINGTTGYEEAAAQGLLAGINAGRYAQEKDAWCPRRDQAYLGVLVDDLVTRGISEPYRMFTSRAEYRLSLREDNADMRLTEIGRELGVVDDVRWDAFNRKRDAVSRETERLRTTWVTPKTLPADEATALLGKPIDHEYSLAELLRRPGVSYDGVCGLRGGECGPSEPLAEDELLLAQIKEQIEIGIKYQGYIERQAGEIERNGANENTRLPDGIDYTEVRGLSFEVSQKLNQFRPETIGQASRISGMTPAAISLLMVHLKKRGLGRRKGADSVPGADVQADNTAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PK4</accession>
    <name>Q63PK4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525734.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109965.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3370"/>
    <dbReference type="EnsemblBacteria" id="CAH37383">
        <property type="protein sequence ID" value="CAH37383"/>
        <property type="gene ID" value="BPSL3370"/>
    </dbReference>
    <dbReference type="GeneID" id="56527782"/>
    <dbReference type="KEGG" id="bps:BPSL3370"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1828"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="81" mass="8590" checksum="0DA400BC01071B39" modified="2004-10-25" version="1">MACSAILPPRAALLPGVARDALRQSYAVAFGGLLEGLTAVTLLCALAAFVFLSRVRVHDEPAAEPARSRERRALALDRECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PP3</accession>
    <name>Q63PP3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109926.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3330"/>
    <dbReference type="DNASU" id="3091789"/>
    <dbReference type="EnsemblBacteria" id="CAH37343">
        <property type="protein sequence ID" value="CAH37343"/>
        <property type="gene ID" value="BPSL3330"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3330"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3784"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMQQWGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="245" mass="28571" checksum="8ABDF6FFF87F1D17" modified="2004-10-25" version="1">MDFWKCPHCGFVVSKTHQEMTQDQWSQLNSSWHHNFENNRESRTTNQPPYADQALVLAILKENDILDLDDGLDYAAGYGTFSKCLKKYFNIGIRIFDRYVHSSDEGMRYVAQKELSRYKLVINSAMFEHVLNRHALDEVNGLVKDDGVLMLHTVVCERIPKDPGWFYIDTMVHTALHTNKSMSILMDQWGYGASIYSPQAKSWFLFKRDNPLIDDLEAKVAGINHELQTTYLHYKRGFVDYWKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PT4</accession>
    <name>Q63PT4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ordered locus">BPSL3288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198631.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109884.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3288"/>
    <dbReference type="EnsemblBacteria" id="CAH37301">
        <property type="protein sequence ID" value="CAH37301"/>
        <property type="gene ID" value="BPSL3288"/>
    </dbReference>
    <dbReference type="GeneID" id="56594008"/>
    <dbReference type="KEGG" id="bps:BPSL3288"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1930"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EMHPQAR"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH37301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="276" mass="30172" checksum="816B6541D47DC6AD" modified="2004-10-25" version="1">MNPIELSFEFFPPKTAEGVDKLRATRAQLAPLKPKFVSVTFGAGGSTQQGTLDTVLDMQKAGLEAAPHLSCIGSSKDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIRAEHGDWFRIEVAAYPEYHPQARSPKADLENFARKVKAGANAAITQYFYNADAYFRFVDDAAKLGVDVPVVPGIMPITNFSQLMRFSEMCGAEVPRWVARRLESFGDDKDSIRAFGADVVTGLCRRLIDAGVPGLHFYTLNGAAATKTVCERLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QN4</accession>
    <name>Q63QN4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone H1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hctB</name>
        <name evidence="4" type="ordered locus">BPSL2990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Might have a role in establishing the nucleoid structure of elementary bodies.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H1/H5 family. HCT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527772.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109584.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2990"/>
    <dbReference type="EnsemblBacteria" id="CAH37000">
        <property type="protein sequence ID" value="CAH37000"/>
        <property type="gene ID" value="BPSL2990"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2990"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2283"/>
    <dbReference type="eggNOG" id="ENOG5031DFK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPTGNRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009970">
        <property type="entry name" value="HC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07382">
        <property type="entry name" value="HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="193" mass="18906" checksum="AAB3368EBB64B3C4" modified="2004-10-25" version="1">MALAKKKPAAKKAAAKKVVAKKAAPAKKAAVKKVAAKKVAVKKVAAKKAAPAKKVAAKKVAAKKAPAKKAAAKKVAVKKVAAKKVAAKKAPAKKAAAKKVAVKKVAAKKVAAKKAAPAKKAAAKKAAPAKKAAAKKAAPAKKAAAKKAAPKKAVVKKAAPATTASTASVAPASGVKTALNPAAAWPFPTGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QW1</accession>
    <name>Q63QW1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527732.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109507.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2913"/>
    <dbReference type="EnsemblBacteria" id="CAH36923">
        <property type="protein sequence ID" value="CAH36923"/>
        <property type="gene ID" value="BPSL2913"/>
    </dbReference>
    <dbReference type="GeneID" id="56528284"/>
    <dbReference type="KEGG" id="bps:BPSL2913"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3326"/>
    <dbReference type="eggNOG" id="ENOG502ZBX5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DNLHDFF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021390">
        <property type="entry name" value="DUF3025"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11227">
        <property type="entry name" value="DUF3025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="30476" checksum="F80BDF4503752FB7" modified="2004-10-25" version="1">MRRRGSSCADGGACFARIDWSAPWLAPLADRGERWTHAAQRGEAAWLRMLNDEARAERLATGRGLPLRFIAQAALPAGIAYETHIAETGAVPTRHNLHDFFNALVWFAYPRIKAALNARQAAAIDAAGVGAVRGGVRDALTLLDENGALFATSDPALAAALRGFDWPTLMRASRDAWGARCDARIVGHALCEKLVDPYKGCTAHAWIVEVPAAYFDWPDARRRAWLDERVAAALAATDPASRGFAPLPVLGVPGWWPANASPAFYDDPQVFRRGRRARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QW7</accession>
    <name>Q63QW7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutathione S-transferase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194030.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109501.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2907"/>
    <dbReference type="EnsemblBacteria" id="CAH36917">
        <property type="protein sequence ID" value="CAH36917"/>
        <property type="gene ID" value="BPSL2907"/>
    </dbReference>
    <dbReference type="GeneID" id="56593674"/>
    <dbReference type="KEGG" id="bps:BPSL2907"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2382"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LSWLMFI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="26225" checksum="59411B74CDFD73A1" modified="2004-10-25" version="1">MLRFFYHPSPNPAKVALFLEEAGVPYEFVPVDTRKGEQHSDAYKAINPNAKTPAIADGDAIVFDSNAILLYLAEKTGQFLPDDTPAARGELLSWLMFVATGIGPYCGQAVHFKHFAPEPKAYAVNRYDFEAWRHWRIVDERLAGRRYMVGERYTIADMAVWGWARAIPRVLGDDAWAQLPHVKRLVDEIDARPAAQRADALKARHAFKVEFDDEARRALFPQNARLAATAGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R37</accession>
    <name>Q63R37_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carbon-nitrogen hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522140.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109431.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2837"/>
    <dbReference type="EnsemblBacteria" id="CAH36847">
        <property type="protein sequence ID" value="CAH36847"/>
        <property type="gene ID" value="BPSL2837"/>
    </dbReference>
    <dbReference type="GeneID" id="56528361"/>
    <dbReference type="KEGG" id="bps:BPSL2837"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2465"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="30462" checksum="0E9A28FB27159FC5" modified="2004-10-25" version="1">MTDRHASASPFPVAALQMVSTPDRERNLAEAGRLIADAAASGARLVLLPEYFCFMGHQDTDKLALAEAYRDGPIQRFLAERAKAHGIWVIGGTLPLKAPEPSRVLNTTLVFDPQGREAARYDKIHLFNFEKGDESFDEARTIRPGDAVRTFDAPFGRVGLSVCYDLRFPELYRRMGDCAMIVVPSAFTYTTGRAHWETLLRARAVENQCYVLAAAQGGKHENGRRTWGRSMLVDPWGEIVAVRDEGAGVVAGEIDPARIADVRQSLPAWRHRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R89</accession>
    <name>Q63R89_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109379.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2784"/>
    <dbReference type="EnsemblBacteria" id="CAH36793">
        <property type="protein sequence ID" value="CAH36793"/>
        <property type="gene ID" value="BPSL2784"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2784"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3180"/>
    <dbReference type="eggNOG" id="ENOG50315PF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GLFWDER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="452" mass="49271" checksum="170401003FDE09BA" modified="2004-10-25" version="1">MHSAGMHTAAPACGGGSAPIRRRAGACAYGAQRSSTPPGHARPTNHGVFMRRVSVPTLLFAASACFFSLNAFSVRATFAAYALLALLALLRAPTLFARQQRLPAIVAYWLLSVSSAFLVSAFGDFYANFFVKFVLIQTYVALAFWLFASGVLAMRSLERTCETLIYVHATFFIVQLGCYLAFGHFIDFDSYIRESDSEALYATKALSDSLISIRALGLYSEPSFYAMTVVPAGAILLLAKRRMTAATIVAFATALLSFSIAAILICALLGGVHFFAGRTSIRIKLVIAAVALAIAPAMYGVYDKRVNQSADYDALGSRTLVLRELRERDALADVFGSGLFWDERNNVGKTHLRGYQVRDSSFYVYLLFATGVAGATAFVGALFMLFRRRGRRSLLPYLLPLLLFKFHALYGMLWLTLLMFVVVAGHAERLPERRERPGTGTGRLSATGASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RC5</accession>
    <name>Q63RC5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glutaryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="8">1.3.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL2747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.7" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109343.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2747"/>
    <dbReference type="EnsemblBacteria" id="CAH36755">
        <property type="protein sequence ID" value="CAH36755"/>
        <property type="gene ID" value="BPSL2747"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2747"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3137"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AAMDCYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="153"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="259"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="413" mass="45126" checksum="F375CADE75099918" modified="2004-10-25" version="1">MQNIVPHSGTIVKRGDDEMAAATFHWDDPLLLDQQLTDDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMGEIGLLGPTIPEQYGGPGLDYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKEKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRARKVPGGYSLSGSKMWITNSPIADVFVVWAKLDEDGRDEIRGFILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENILPHVKGLRGPFTCLNSARYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RR6</accession>
    <name>Q63RR6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ordered locus">BPSL2605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186294.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109201.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2605"/>
    <dbReference type="EnsemblBacteria" id="CAH36613">
        <property type="protein sequence ID" value="CAH36613"/>
        <property type="gene ID" value="BPSL2605"/>
    </dbReference>
    <dbReference type="GeneID" id="56594871"/>
    <dbReference type="KEGG" id="bps:BPSL2605"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2750"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="320" mass="34138" checksum="4EA1A319D2D1A4DF" modified="2004-10-25" version="1">MSTPKHAKVLILGSGPAGYTAAVYAARANLSPLLITGIAQGGQLMTTTDVENWPADADGVQGPELMQRFLAHAQRFNTEIVFDHIHTAKLHEKPIRLIGDSGEYTCDSLIIATGASAQYLGLQSEEAFMGRGVSACATCDGFFYRGQNVAVVGGGNTAVEEALYLTGIAKKVTVIHRRDKFRAEPILVDRLLEKEKEGAVEIKWDHVLDEVTGDDSGVSGVRIKHVTTGATEDVAVQGLFIAIGHKPNTDIFKGQLEMKDGYIITNSGLSGNATGTSVPGVFAAGDVQDHIYRQAITSAGTGCMAALDAQRYLESLHDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S28</accession>
    <name>Q63S28_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550121.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109089.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2494"/>
    <dbReference type="EnsemblBacteria" id="CAH36500">
        <property type="protein sequence ID" value="CAH36500"/>
        <property type="gene ID" value="BPSL2494"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2494"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2888"/>
    <dbReference type="eggNOG" id="COG2314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PTRSGWP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="6">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="16718" checksum="4FF065F74C1E641E" modified="2004-10-25" version="1">MSSSTSTPPRFRSKTLTALLAFLFGSLGTHRFYLYGWKDLAGWAHLLATIVGVPGFMLLAASGRAAALGWWLAVPGAISLLAAFLAALVYGLRPDDKWDAQFNASTGRHSRSGWGVVFVVIFSLLIGAFLLMTGLALAFQTYFESQVEAAKQISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S51</accession>
    <name>Q63S51_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thymidylate synthase</fullName>
            <shortName evidence="4">TS</shortName>
            <shortName evidence="4">TSase</shortName>
            <ecNumber evidence="1 4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thyA</name>
        <name evidence="6" type="ordered locus">BPSL2473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 4"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189921.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109066.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2473"/>
    <dbReference type="EnsemblBacteria" id="CAH36477">
        <property type="protein sequence ID" value="CAH36477"/>
        <property type="gene ID" value="BPSL2473"/>
    </dbReference>
    <dbReference type="GeneID" id="56596487"/>
    <dbReference type="KEGG" id="bps:BPSL2473"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2914"/>
    <dbReference type="eggNOG" id="COG0207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KQYLDLC"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="5">
        <location>
            <begin position="2"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="323" mass="36622" checksum="960BECE1CF0CCFE3" modified="2004-10-25" version="1">MKQYLDLVRTILDTGTWQSNRTGIRTIGIPGAMLRFDLQQGFPAVTTKKLAFKSAIGELVGFLRATRSAADFRALGCKVWDANANENAQWLANPYRRGVDDLGDVYGVQWRRWPGYKVLDAHADAQIADATSRGFRAVARFDEDGAQKVLLHKAIDQLRDCLDTIVRDPSSRRILFHGWNPAVLDEIALPACHLLYQFLPNVERREISLCLYIRSNDVGLGTPFNLAEGAALLTLVGRLTGYTPRWFTYFIGDAHIYENQLGMLKQQLEREPFDSPRLEIAERVPEYAKTGQYEPQWLERIEPSDFTLVGYRHHEPLSAPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SC8</accession>
    <name>Q63SC8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL2396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539843.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108988.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2396"/>
    <dbReference type="EnsemblBacteria" id="CAH36398">
        <property type="protein sequence ID" value="CAH36398"/>
        <property type="gene ID" value="BPSL2396"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2396"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3004"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WWVATVR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="37692" checksum="838D5C34B17C7FF8" modified="2004-10-25" version="1">MTRWIKWLGWPIGIAILLALVVHEGAGDAVRVIGQAGFALLWLVPFHGLPLLLDAHAWRLLLDKRASLPFLWWIATVREAVNRLLPVVGVGGEIVGIRLARWRVPDASRVTASVIVEVLVTIAVQYAFAALGLVLLLAATQESVGAKTIGVALALSLPIPVLGFVLMRRGGVFHAIERFAGRLLGDSHRLLQGVDGKRLDADIDALMSRAGLLFRAFFWQLAGYVAGALEIYWALALLGHPISIGGAIAIEAMTQAVRHAAFMVPGGLGVQEATVVLLAQMFGVDREAALSLALVKRARELLFGALALGSWQVVELSRTRRRIRSHARRAARVAAAEARRERETEPSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD8</accession>
    <name>ASTB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-succinylarginine dihydrolase</fullName>
            <ecNumber evidence="1">3.5.3.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">astB</name>
        <name type="ordered locus">BPSL2386</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19533"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58241"/>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
            <dbReference type="EC" id="3.5.3.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinylarginine dihydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.23" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192611.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108978.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63SD8"/>
    <dbReference type="SMR" id="Q63SD8"/>
    <dbReference type="STRING" id="272560.BPSL2386"/>
    <dbReference type="EnsemblBacteria" id="CAH36388">
        <property type="protein sequence ID" value="CAH36388"/>
        <property type="gene ID" value="BPSL2386"/>
    </dbReference>
    <dbReference type="GeneID" id="56596294"/>
    <dbReference type="KEGG" id="bps:BPSL2386"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3016"/>
    <dbReference type="eggNOG" id="COG3724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TLNDWVD"/>
    <dbReference type="UniPathway" id="UPA00185">
        <property type="reaction ID" value="UER00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009015">
        <property type="term" value="F:N-succinylarginine dihydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:arginine catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019545">
        <property type="term" value="P:arginine catabolic process to succinate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01172">
        <property type="entry name" value="AstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037031">
        <property type="entry name" value="AstB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007079">
        <property type="entry name" value="SuccinylArg_d-Hdrlase_AstB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04996">
        <property type="entry name" value="AstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03241">
        <property type="entry name" value="arg_catab_astB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000262340" description="N-succinylarginine dihydrolase">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01172"/>
        </source>
    </evidence>
    <sequence length="446" mass="48138" checksum="934449B79BB55B2F" modified="2004-10-25" version="1">MNAKEANFDGLVGPTHNYAGLSFGNVASLSNEKSDANPKAAAKQGLRKMKQLADLGFAQGVLPPQERPSLRLLRELGFSGKDADVIAKAARQAPELLAAASSASAMWTANAATVSPSADTSDARVHFTPANLCSKLHRAIEHESTRRTLAAIFADEARFAVHDALPGTPALGDEGAANHTRFCAEYGAPGVEFFVYGRAEYRRGPEPTRFPARQTFEASRAVAHRHGLREEATIYAQQRPDVIDAGVFHNDVIAVGNRDTLFCHEHAFVDRQAVYDALAASLGALGAQLNVIEVPDRAVSVADAVGSYLFNSQLLAREDGTQMLVVPQECRENANVAAYLDALVAGNGPIRDVRVFDLRESMKNGGGPACLRLRVVLNDAERAAVKPNVWIGDALFASLDAWIDKHYRDRLSPVDLADPALLDESRTALDELTQILGLGSLYDFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SG9</accession>
    <name>Q63SG9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550161.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108947.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2354"/>
    <dbReference type="EnsemblBacteria" id="CAH36356">
        <property type="protein sequence ID" value="CAH36356"/>
        <property type="gene ID" value="BPSL2354"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2354"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3058"/>
    <dbReference type="eggNOG" id="COG4243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVFGHAP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="377" mass="38710" checksum="83468475A7C895D8" modified="2004-10-25" version="1">MPAPKQPAASLARPLVRATAGVVIVALLACGIATGLARLGAPAPPHAVSRLAWHGVLMIPVFFGAVIGVERAVALGARWAYLVPATAAAAGLSLLAGAPAMRAAALLTGAASIALAVSATVLRRQAALFLWVLAASVGCWWAGNAVWLLTGDPFAAVAWWLAFLILTIAAERLELTRVRPLPRGASACFCGIVALLPAAAALASWQPLPALRLFGAGELLLAAWLVRYDVARRTVRQRGLTRFIAVCLLSGYGWLAVSGALGLDGALAPGHPAHDAALHALTLGFVFSMILGHMPIIVPAVARLRVAYRPFFYAPLALLHAAVALRVAGGLLDAFALTRAGGEIAALAIASFAATLAIGIALARRSASHRGAGKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SY3</accession>
    <name>Q63SY3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aceA</name>
        <name evidence="9" type="ordered locus">BPSL2188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2009-07" db="PDB data bank">
            <title>Crystal structure of Isocitrate Lyase from Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Staker B.L."/>
                <person name="Arakaki T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Can also use Mn(2+) ion.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192082.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108783.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="PDB" id="3I4E">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.69 A"/>
        <property type="chains" value="A/B/C/D=1-435"/>
    </dbReference>
    <dbReference type="PDBsum" id="3I4E"/>
    <dbReference type="SMR" id="Q63SY3"/>
    <dbReference type="STRING" id="272560.BPSL2188"/>
    <dbReference type="EnsemblBacteria" id="CAH36190">
        <property type="protein sequence ID" value="CAH36190"/>
        <property type="gene ID" value="BPSL2188"/>
    </dbReference>
    <dbReference type="GeneID" id="56595971"/>
    <dbReference type="KEGG" id="bps:BPSL2188"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3261"/>
    <dbReference type="eggNOG" id="COG2224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEKDWAE"/>
    <dbReference type="EvolutionaryTrace" id="Q63SY3"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="314"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="3I4E"/>
        </source>
    </evidence>
    <sequence length="435" mass="47775" checksum="3BA3C8DD3F9904C8" modified="2004-10-25" version="1">MSRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFGGVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAEAADLITSDIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T07</accession>
    <name>DNLJ_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">BPSL2164</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009937986.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108759.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T07"/>
    <dbReference type="SMR" id="Q63T07"/>
    <dbReference type="STRING" id="272560.BPSL2164"/>
    <dbReference type="EnsemblBacteria" id="CAH36166">
        <property type="protein sequence ID" value="CAH36166"/>
        <property type="gene ID" value="BPSL2164"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2164"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3287"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000313165" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="610"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="691" mass="75582" checksum="25906E1D6D880F24" modified="2004-10-25" version="1">MARSPVEPPASQPAKRAAWLRAELERANYAYYVLDQPDLPDAEYDRLFVELQRIEAEHPDLVTPDSPTQRVGGEAASGFTPVVHDKPMLSLNNGFADEDVIAFDKRVADGLDKATDLAGTVTEPVEYACELKFDGLAISLRYENGRFVQASTRGDGTTGEDVTENIRTIRAIPLTLKGKRIPRMLDVRGEVLMFKRDFARLNERQRAAGQREFANPRNAAAGSLRQLDSKITASRPLSFFAYGIGVLDGADMPDTHSGLLDWYETLGLPVNRERAVVRGAAGLLAFFHSVGERRESLPYDIDGVVYKVNRRDEQDRLGFVSRAPRFALAHKFPAQEALTKLIAIDVQVGRTGAITPVARLEPVFVGGATVTNATLHNEDEVRRKDIRIGDTVIVRRAGDVIPEVVSAVLDRRPADAQEFVMPTECPECGSRIERLPDEAIARCTGGLFCPAQRKQALWHFAQRRALDIDGLGEKIIDQLVEQNLVRTPADLFNLGFSTLVGLDRFAEKSARNLIDSLEKAKHTTLARFIYALGIRHVGESTAKDLAKHFGSLDPIMDAPIDALLEVNDVGPIVAESIHQFFAEEHNRTVIEQLRARGKVTWPEGPPAPRAPQGVLAGKTVVLTGTLPTLTREAAKEMLEAAGAKVAGSVSKKTDYVVAGADAGSKLAKAEELGIPVLDEAGMHTLLEGHAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T28</accession>
    <name>PSRP_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative phosphoenolpyruvate synthase regulatory protein</fullName>
            <shortName evidence="1">PEP synthase regulatory protein</shortName>
            <shortName evidence="1">PSRP</shortName>
            <ecNumber evidence="1">2.7.11.33</ecNumber>
            <ecNumber evidence="1">2.7.4.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pyruvate, water dikinase regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">BPSL2143</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46020"/>
            <dbReference type="Rhea" id="RHEA-COMP:11425"/>
            <dbReference type="Rhea" id="RHEA-COMP:11426"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48580"/>
            <dbReference type="Rhea" id="RHEA-COMP:11425"/>
            <dbReference type="Rhea" id="RHEA-COMP:11426"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="EC" id="2.7.4.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.33" evidence="1"/>
    <dbReference type="EC" id="2.7.4.28" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192738.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108738.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T28"/>
    <dbReference type="SMR" id="Q63T28"/>
    <dbReference type="STRING" id="272560.BPSL2143"/>
    <dbReference type="EnsemblBacteria" id="CAH36145">
        <property type="protein sequence ID" value="CAH36145"/>
        <property type="gene ID" value="BPSL2143"/>
    </dbReference>
    <dbReference type="GeneID" id="56595928"/>
    <dbReference type="KEGG" id="bps:BPSL2143"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3310"/>
    <dbReference type="eggNOG" id="COG1806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YAQCEFE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01062">
        <property type="entry name" value="PSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026530">
        <property type="entry name" value="PSRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000196642" description="Putative phosphoenolpyruvate synthase regulatory protein">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01062"/>
        </source>
    </evidence>
    <sequence length="271" mass="30834" checksum="26626BCCDEFA9FC4" modified="2004-10-25" version="1">MLPTVFIVSDGTGITAETFAHSILSQFDQKFRLVRVPFIDSIEKAYDTVRKINDAAQHDGRRPIVFTTLVDGESNEIVKRSNALVLDMFQRFVEPLEQELQLKSSHAMGRVHQNADTEEYKTRIEAINFSLAHDDGQSNRNLADADVILIGVSRSGKTPTSLYLAMQYGVKAANYPLIPEDFERGKLPTPLHPHRDKLFGLSIDPMRLSEIRNERRPGSKYAAPENCRYEINEAEAMMRREGVKWLSSTHKSIEEIATTILQEIKLERQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TJ9</accession>
    <name>Q63TJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative FAD-binding reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191226.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108567.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1969"/>
    <dbReference type="EnsemblBacteria" id="CAH35968">
        <property type="protein sequence ID" value="CAH35968"/>
        <property type="gene ID" value="BPSL1969"/>
    </dbReference>
    <dbReference type="GeneID" id="56595428"/>
    <dbReference type="KEGG" id="bps:BPSL1969"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4118"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CNDNMLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="473" mass="50494" checksum="A9E0A317EAEF713B" modified="2004-10-25" version="1">MTSTSAFVDACRHAIGADHVLTDSHDTAPFLTDWRRRYQGAACAVLRPANTEEVAALVKLALEHRVALVPQGGNTGLAGGATPDAGGKQAVLSLARLNRVRALDPHNNTITVEAGVILADAQARARDADRLFALSLAAEGSCTIGGNLATNAGGTAVLRYGNARELCLGLEVVTAQGEVWDGLRGLRKDNTGYDLRDLFIGAEGTLGIITAAVMKLHPLPAAKVTALAALESPHAALDFLALAQRAAGPLLTGFELMSDFCMKLVGKHYPQLRYPFDAAHPQTVLLELSDNESEAHARALFETMMEQAFEAGLVVDAVVAENLAQSRAFWDLREHIPLAQADEGLNIKHDIAVPISAIAHFIDETDAAIQAAAPGARMVTFGHLGDGNLHYNVQMPEGGDPKAFLAEHQAPINRIVYDNVHKHRGTISAEHGIGQLKIDDAQRYKAAVEIRLMRALKAALDPLNLMNPGKVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TX1</accession>
    <name>Q63TX1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108445.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1846"/>
    <dbReference type="EnsemblBacteria" id="CAH35845">
        <property type="protein sequence ID" value="CAH35845"/>
        <property type="gene ID" value="BPSL1846"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1846"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2078"/>
    <dbReference type="eggNOG" id="ENOG5033VMB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRVEWQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="18168" checksum="6B76B82EC54AE710" modified="2004-10-25" version="1">MHSIGPISESRSAVIFQKQKQSGKRMTQHKVHPRLEQALTRGDLAIRQANSTRATAVLNALGKMIVEASATIGVEASIDIAQGERVYDPVNGVWPQKMLVSFDGPVEDADPEELRTVYLLADDPGTMFRVEWHRADGKLGRQEGGPLATVAFLTDVEMPWSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U04</accession>
    <name>Q63U04_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fimbriae-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191346.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108412.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1813"/>
    <dbReference type="EnsemblBacteria" id="CAH35812">
        <property type="protein sequence ID" value="CAH35812"/>
        <property type="gene ID" value="BPSL1813"/>
    </dbReference>
    <dbReference type="GeneID" id="56595602"/>
    <dbReference type="KEGG" id="bps:BPSL1813"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3934"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMVVCAE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="173"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="314" mass="33202" checksum="DF1E4AF4BD4CDC9A" modified="2004-10-25" version="1">MTPAALSITVLLALVAVAALAWLLTRDVAVRRRVAQRARASAARAAAVYAPVDDGARSVPRRVAQRVASLGERVPVVDATQRMKLAARLASAGFREHRAVSVMAGLKLVVGACAGLAALALGAHVPRVGDYVVLRVLMMAGAFVIGMMLPEHALGFVLARRQKTIAAYLPDALDLLVICTNAGNSLAVAIRRVASELKTICPPLADEFSVCADELQIGGDAAFALNAMAARIGLPSMRALVTTLVQSQQYGTPITQSLRMLSRTERAMQMIALEEKAAKLAPKMTLPMMLFVMPTVALIAAGPAVIRLIAVFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U65</accession>
    <name>Q63U65_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amino-acid transport-related exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531272.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108351.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1751"/>
    <dbReference type="EnsemblBacteria" id="CAH35750">
        <property type="protein sequence ID" value="CAH35750"/>
        <property type="gene ID" value="BPSL1751"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1751"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3851"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAQYWKG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266783" evidence="1">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="25"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="371" mass="38757" checksum="21B2B3CCC8AD903F" modified="2004-10-25" version="1">MNVRMGCLSLLAAVAFDAHAQSSVVRIGVAMPLTGPVAHLGKDVQNGAQLAVDELNRAPPTIEGKPVKFVLVVEDDQGDPRQAVQVAQRLVDARVAGVVGDLNSGPTIVAAKVYAAAGIAQIAPAATHPAYTQLGYKTAFRLMATDNQQGASLAGLAAKLAKGRPIALIDDRGAYGQGLIDQTEKTLRASGVTRIIRDYTTDTAVNFASILTRVKGAHAAVIVYGGADAQAGPMVRQMKALGIDAAFVGSDGVCTGQWTALSSGANEGQFCTQAGDPRARMAGYAAFERRFEARYGKVIVFAPYGYDAVMLLADAMRRANSTEPAALLGALATTRYDGVIGRIRFSPQGDNLNGAVTVYRVQRGALVPVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U77</accession>
    <name>Q63U77_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192711.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108339.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1739"/>
    <dbReference type="EnsemblBacteria" id="CAH35738">
        <property type="protein sequence ID" value="CAH35738"/>
        <property type="gene ID" value="BPSL1739"/>
    </dbReference>
    <dbReference type="GeneID" id="56595523"/>
    <dbReference type="KEGG" id="bps:BPSL1739"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3836"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DKICIMN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="312" mass="33159" checksum="AF99984961D78203" modified="2004-10-25" version="1">MIEIERVSRLFGDLAAVDDVSLAVARGTVTALVGASGSGKSTLLRMINRLIAPTSGTIRVDGVDTASVPAETLRRGIGYVIQGHGLFPHWTVARNVATVPRLLGWRAARVDARVRELLELFELDYDTYARKLPHQLSGGQQQRVGVARALAAEPAILLMDEPFGALDPIIRGKAQDDLVALQRRLGITVVIVTHDIDEALRLGDQIAVMDAGRILQAGSPAEILGRPQPGVVERLVAGLDRPLRLLALTRVDALAEPGAAPGEPISGALTLRDAISELLWRGARALPVSSADGAAARRITLDAIVAQAKRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U90</accession>
    <name>Q63U90_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521522.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108326.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63U90"/>
    <dbReference type="STRING" id="272560.BPSL1726"/>
    <dbReference type="EnsemblBacteria" id="CAH35725">
        <property type="protein sequence ID" value="CAH35725"/>
        <property type="gene ID" value="BPSL1726"/>
    </dbReference>
    <dbReference type="GeneID" id="56595508"/>
    <dbReference type="KEGG" id="bps:BPSL1726"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3819"/>
    <dbReference type="eggNOG" id="COG3251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="REDCLAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="74" mass="8507" checksum="8861725052E20101" modified="2004-10-25" version="1">MDDELYFVVRNNEGQYSVWMDGRSLPAGWETVGEPATKQQCLQRIEQLWTDMVPASVREHLNQHSGPGIDYAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB0</accession>
    <name>Q63UB0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">BPSL1705</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108306.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1705"/>
    <dbReference type="EnsemblBacteria" id="CAH35703">
        <property type="protein sequence ID" value="CAH35703"/>
        <property type="gene ID" value="BPSL1705"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1705"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1913"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPEVHAF"/>
    <dbReference type="PHI-base" id="PHI:4666"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008640">
        <property type="entry name" value="Adhesin_Head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008635">
        <property type="entry name" value="Coiled_stalk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005594">
        <property type="entry name" value="YadA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03895">
        <property type="entry name" value="YadA_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05658">
        <property type="entry name" value="YadA_head"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05662">
        <property type="entry name" value="YadA_stalk"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267151" evidence="12">
        <location>
            <begin position="24"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="473"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="771"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1149"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1177"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="1256"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1387"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1401"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1415"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1429"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1443"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_head" evidence="14">
        <location>
            <begin position="1457"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_stalk" evidence="15">
        <location>
            <begin position="1501"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="domain" description="YadA_anchor" evidence="13">
        <location>
            <begin position="1548"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1317"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1374"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1384"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH35703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1606" mass="148821" checksum="10AC80FE30BBE12D" modified="2004-10-25" version="1">MSSIALAACILIGSLGSTLPAVAGTVIGGGAQYPNSVGGTSSTTGDLGNSYIGASGMGTAITGDNDCLSLTSTRNVLNSANVGWLLGTTSQTTDPGPLYPGPGAENNQTISYSGTSNFSGGGNSAAGAQATLAWGFNSFAAGCGNKSLGMGSSTLGLNNMASLAGSTAIGIANTASGAGGTAIGLYNTAAGTGSVAMGIGSQATGNGTIALGYGGGGTSSNATLASGSNAIAIGGDATKGAQATGSDSIAMGSEAAASSSSTTAIGQYATASNTNATALGAGGTSAATGVIASGAGAVALGGNSTQGAQALASNAIAIGGQSQAASAGAIAIGQSALATGGQAVSVGVGNTANGNGAVAIGDPNVATGTGAVALGANNTATGQGAVALGNADIATGQGSVALGNVSTAAGAGSVAFGSNAVANNTNDVALGSGSVTAAPNPTGSATIGGTTYSFEGTNPTSVVSVGAVGAERQITNVAAGQLTATSTDAVNGSQLYSTNQAINTLSTSTSTGLSSANSSIASLSTGLASSGNLASLSTSTSTGLSSANSSIASLSTSTSTGLSTTNSNIGSLSTGLSTTNSTVASLSTSTSTGLSSATSSITSLSTSTSSGISTAQSGVNSLSTGLSTTNSAVTSLSTSTSTGLSSATSSITSLSTSTSTGIGSLSTGLSTTDSSVTSLSTSTSSGISTAQSGVNSLSTGLSTTNSTVTSLSTSASTGLSSANSSITSLSTSTSTGLSSLSTGIANSVQYDNTSHTQVTLGGAGATTPVTLTNVAAGVNPTDAVNMSQLTSLSTSTSTGLSTTNSNIGSLSTALSTTDSSVTSLSTSTSSGISTAQSGVNSLSTGLSTTNSTVASLSTSTSTGLSSATSSITSLSTSTSTGIGSLSTGLSTANSSVTSLSTSTSSGISTAQSGVNSLSTGLSTTNSTVASLSTSTSTGLSSATSSITSLSTSTSTGIGSLSTGLSTANSSVTSLSTSTSSGISTAQSGVNSLSTGLSTTNSAVTSLSTSTSTGLSSLSTGLSATNSNISSLSTSTSNGLSTANSNISSLSTGLSSLSTAVNGGGTKYFHANSAQPDSQALGTNAIAVGPAATASGASGIAIGDTANAAATGAVAIGQTAVATGGQAVSIGVANTASGDGAVAIGDPNVATGTGAVALGANNSANGQGAVALGNANVATGTGSLALGSTSTAAGGGSIALGTNAIANNANDVALGSGSVTAAANPVASALIAGQTYSLAGGSPTSVVSVGAPGAERQITNVAAGQVSATSTDAVNGSQMNAVTQALVSLSTSTANALSTTQNGLSSLSTGLSTTQSSVSSLSTGLSTTSGNVSSLSTGLSTTQSDVASLSTGLSTTNSNLASLSTAVSNGGIHTNGAGGTSMGPGADASGSNSTAVGGAASASGANATALGQASNASGNNSTALGQASSASGSGSTAVGQGASASGDGSSAFGQGAIASGTNSTALGAHSTASAPNSVAIGANSVASAPNTVSFGSQGHERRLTNVAPGMDGTDAANMSQLWGVQSSVDQAARRAYSGVAAATALTMIPEVDPGKTIAVGIGAGSYQGYSASAIGVSVRFSDNLKAKLGMGISSQGSTYGGGISYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UC7</accession>
    <name>Q63UC7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521482.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108289.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1679"/>
    <dbReference type="EnsemblBacteria" id="CAH35678">
        <property type="protein sequence ID" value="CAH35678"/>
        <property type="gene ID" value="BPSL1679"/>
    </dbReference>
    <dbReference type="GeneID" id="56529379"/>
    <dbReference type="KEGG" id="bps:BPSL1679"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3759"/>
    <dbReference type="eggNOG" id="COG3535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KICVEMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="DUF917"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="DUF917_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="DUF917_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="DUF917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="363" mass="37517" checksum="1ED4CBAFA85A8D62" modified="2004-10-25" version="1">MGRILSSKDVEAAVKGGSVFACGGGGWADHGRELGMLAVTIGRPELVAIDELPDDAWIATAAAIGAPGGLTDWQMLGADYVKAAQLVQEALGAPLAGLIIGQNGMSSTLNAWLPSALLGAKVVDAVADLRAHPTGDMGSLGLASSSEPMIQAAAGGNRAKHAYMEVVVRGATAKVSPVLRKAADMAGGFIASCRNPIRASYVRRHAALGGISRALALGEAIIDAERRGGSAVIDAICAATQGEIIVSGKVERNTLAYTREAFDVGLVYLGEGAKRAVIHVMNEHMAVDDAHGERIATYPDVITTLDSDGRPVSAGQLKEGMEIHVLRVTKTHIPLSSSVFDPAIYPPVETALGISIADYALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UE2</accession>
    <name>Q63UE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521465.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108274.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1663"/>
    <dbReference type="EnsemblBacteria" id="CAH35661">
        <property type="protein sequence ID" value="CAH35661"/>
        <property type="gene ID" value="BPSL1663"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1663"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3740"/>
    <dbReference type="eggNOG" id="ENOG502Z7Q6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CVRNVAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="291" mass="33022" checksum="7CAAA30F0958133F" modified="2004-10-25" version="1">MNIHFISGLPRAGSTLLSVLLAQNPRIHATITSPLFSIATAMRQAMSTSSEHYQLMNERKRLKLYAGLFDSYYEDAYKAGKTIVFDSNRSWLQLQALTSTVFPGARTIVCVRSPSWVIDSLEQLFLANAAVIPQYFNDAFEARSLYSRTDALMRPDRMVGASWSNLREAFYGPQSEQLLIVEYTALVADPEATLRTLYNFIGEPFFEHKYSELRIESQDDIDRFDYAMGVPGLHRVGGEVRRRARATVLPPELYERLERMAFWREVNATNAKVLLGPPETPANRHATQTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UE9</accession>
    <name>Q63UE9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108267.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1657"/>
    <dbReference type="EnsemblBacteria" id="CAH35654">
        <property type="protein sequence ID" value="CAH35654"/>
        <property type="gene ID" value="BPSL1657"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1657"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3732"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PLRDECL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="103"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="277" mass="31779" checksum="4201871BEB85B200" modified="2004-10-25" version="1">MLAIREKVNISERRACRLVGLSRSVLHYDAKPDHENEVLAARLVKLAHERRRFGYRRLHALVEREGTHANHKRIYRLYREAGLAVRRRRKRHGVMIEREQLALPGAPNEVWSIDFVMDALSNGRRVKCLTVVDDFTKEAVDIVVDHGISGLYVARALDRAARFRGYPKAVRTDQGPEFTSRALDQWAYANGVTLKLIQAGKPTQNAYIESFNGKFRDECLNEHWFTTLAHARAVIAAWRQDYNEQRPHSALNYLAPSEFAAKHRATADAPAAFQEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UP8</accession>
    <name>Q63UP8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL1548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538238.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108168.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1548"/>
    <dbReference type="EnsemblBacteria" id="CAH35549">
        <property type="protein sequence ID" value="CAH35549"/>
        <property type="gene ID" value="BPSL1548"/>
    </dbReference>
    <dbReference type="GeneID" id="56595710"/>
    <dbReference type="KEGG" id="bps:BPSL1548"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3593"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="313"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH35549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="530" mass="59531" checksum="01E0832200FF9D8A" modified="2004-10-25" version="1">MLSTANITMQFGPKPLFENISVKFGEGNRYGLIGANGCGKSTFMKILGGDLEPSAGNVALEPNVRLGKLRQDQFAYEDVRVLDVVMMGHTEMWAAMTERDAIYANPEATDDDYMHAAELEAKFAEYGGYDAEARAGALLLGIGIEEKFHSGPMRDVAPGWKLRVLLAQALFSNPDVLLLDEPTNNLDINSIRWLEDTLNNYDSTMIIISHDRHFLNSVCTHMADMDYGTLKVWPGNYDDYMLASAQARERQAAANARAKERVAELQDFVRRFSANKSKARQATSRAKQIDKIKIEEFKPSSRQNPFIRFEFEKKLHNIAVVADSITKKYERTIFENFNLSVQPGERIAIIGENGAGKTTLLRALFGNLTLDHGTVKWAENANVGYMPQDTYEEFPNDVTLMDWIDQYRKDGDDETMVRGTLGRLLFSADDIKKSVKVLSGGEKGRMIWGKLMLGRHNVLLMDEPTNHMDMESIESLQIALEKFEGTLIFVSHDREFVSGLANRIIEVTTEGKLVDFGGNYEDFLASKGLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UT8</accession>
    <name>RLMD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD</fullName>
            <ecNumber evidence="1">2.1.1.190</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA(m5U1939)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmD</name>
        <name type="synonym">rumA</name>
        <name type="ordered locus">BPSL1508</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10278"/>
            <dbReference type="Rhea" id="RHEA-COMP:10279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.190"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.190" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192701.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108128.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63UT8"/>
    <dbReference type="SMR" id="Q63UT8"/>
    <dbReference type="STRING" id="272560.BPSL1508"/>
    <dbReference type="EnsemblBacteria" id="CAH35509">
        <property type="protein sequence ID" value="CAH35509"/>
        <property type="gene ID" value="BPSL1508"/>
    </dbReference>
    <dbReference type="GeneID" id="56595753"/>
    <dbReference type="KEGG" id="bps:BPSL1508"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3545"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070041">
        <property type="term" value="F:rRNA (uridine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01010">
        <property type="entry name" value="23SrRNA_methyltr_RlmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001566">
        <property type="entry name" value="23S_rRNA_MeTrfase_RlmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000161891" description="23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="465" mass="51030" checksum="D521FF6680B3C9F7" modified="2004-10-25" version="1">MSEAVPLSTRRASSAGDAPGRAPVLDIDSLDMEARGVGRVVDENGEPGKVIFVEGALPGERVTYSSFRRKPTYEQAQVVDILRPSVMRTQPKCAFFGTCGGCSMQHLDMRAQVAIKQRVLEDNLWHLAKLRAEAMFAPIHGPSWGYRYRARLTVRHVAKKGGVLVGFHEKKSSYVADMTSCEVLPPHVSAMLVPLRRLVEQLSIRDRMPQIELAVGARVTALVLRVLEPINAADEALLREFADTHRVQFWLQPKGPDTVAPFYPLDAQLDYTLPEFGIRMPFKPTDFTQVNHQINRVLVGRALRLLAPERGDRVLDLFCGIGNFTLPLARLAREVVGIEGSDALTARALENAKENGVDGHTSFACRNLFEVTADDLRALGAFDKFLVDPPREGALAVSKALAEIAQSGAGPLPARIVYVSCNPSTLARDAGLLVHEAGYRLKGAGVVNMFPHTSHVESIALFERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UV1</accession>
    <name>Q63UV1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rho</name>
        <name evidence="11" type="ordered locus">BPSL1495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521321.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108115.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1495"/>
    <dbReference type="EnsemblBacteria" id="CAH35496">
        <property type="protein sequence ID" value="CAH35496"/>
        <property type="gene ID" value="BPSL1495"/>
    </dbReference>
    <dbReference type="GeneID" id="56529220"/>
    <dbReference type="KEGG" id="bps:BPSL1495"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3530"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="420" mass="47413" checksum="0E77B6E498753B9D" modified="2004-10-25" version="1">MHLSELKSLHVSELIEMANGLEIENANRLRKQELMFAILKKRAKTGETIFGDGTLEVLPDGFGFLRSPEMSYLASTDDIYISPSQIRRFNLHTGDTIEGEVRTPKDGERYFALVKVDKVNGQPPEASKHKIMFENLTPLHPNKPLSLEREMRGEENVTGRIIDMIAPIGKGQRGLLVASPKSGKTVMLQHIAHAIKQNHPDVILFVLLIDERPEEVTEMQRSVAGEVIASTFDEPATRHVQVAEMVIEKAKRLVEMKHDVVILLDSITRLARAYNTVIPASGKVLTGGVDANALQRPKRFFGAARNIEEGGSLTIIGTALIETGSRMDDVIYEEFKGTGNMEVHLERRLAEKRVYPSINLNKSGTRREEMLIKPEILQKIWVLRKFIHDMDEVEAMEFLLDKIRQTKNNAEFFDLMRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V20</accession>
    <name>Q63V20_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL1424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521274.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108046.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1424"/>
    <dbReference type="EnsemblBacteria" id="CAH35426">
        <property type="protein sequence ID" value="CAH35426"/>
        <property type="gene ID" value="BPSL1424"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1424"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3444"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGAGWPF"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="10">
        <location>
            <begin position="295"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="476"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="9">
        <location>
            <begin position="604"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="694" mass="74389" checksum="71EB8CC91B58DA93" modified="2004-10-25" version="1">MAVDYTTRDGVAVITLNNPPVNGLGLSTRLGIMEGLERAQRDPAVAAIVLTGAGRAFSGGADITEFNTPKALQEPTLHTVIDAVEASGKPVVVAIHSVAMGGGLELALGAHYRVASAGAQIALPEVKLGLLPGAGGTQRLPRAVGLETALNMIVSGAPVPSEQLAKSGLFDAFVEGDLLEAAVAFARKAGAASGPHPRVRDREIVHENAAGFIQFARNSVKAVAQHYPAPHKCIDAIEAGVLQGFDKGLAFERDCFVALVQTPESRALRHAFFGERAAGKIADVPADTAVRGIESVAVIGAGTMGGGITMNFLNAGLPVTLLETKQEALERGLATIRKNYDAQVSKGKLTQEKLDARMALLRPTLSYDDLKDADLVIEAVFEELGVKEQVFKRLDEVAKPGAILASNTSTLDVNKIAAFTGRPQDVVGLHFFSPANVMKLLEVVRGEHTAKDVLATVMQLAKKIRKTAVVSGVCDGFIGNRMVEQYIRQALFMLEEGALPAQIDRAIEAFGFAMGPFRMSDLAGNDIGWAIRKRRYVEQPDLHYSKIADRLCEQGRFGQKTGAGWYDYVPGERRAKPSKLVDEMIVAYSSERGVARRQIGDAEIVERLVYALVNEGAKILEEKIASKASDIDMVYLTGYGFPLWRGGPMLYADTVGLYNVERAMRGYAQRANGDAWQIAPSIVELAKSGRGFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V39</accession>
    <name>Q63V39_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 14" type="primary">lon</name>
        <name evidence="14" type="ordered locus">BPSL1405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193454.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108027.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1405"/>
    <dbReference type="EnsemblBacteria" id="CAH35406">
        <property type="protein sequence ID" value="CAH35406"/>
        <property type="gene ID" value="BPSL1405"/>
    </dbReference>
    <dbReference type="GeneID" id="56595861"/>
    <dbReference type="KEGG" id="bps:BPSL1405"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3418"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="594"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="724"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="805" mass="89092" checksum="830832F22D8AD2E6" modified="2004-10-25" version="1">MSGTQLLPSERTTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEVAMEGGKHIMLVAQKTAAKDEPTEKDMYDVGCIANILQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIALPWRKKSKVNNDLSNAEKVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIPPPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIDVAEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGLKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERLPNALPEEEAKAAPVAEPAKDAGSTEVVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF7</accession>
    <name>Q63VF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191983.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107909.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1288"/>
    <dbReference type="EnsemblBacteria" id="CAH35282">
        <property type="protein sequence ID" value="CAH35282"/>
        <property type="gene ID" value="BPSL1288"/>
    </dbReference>
    <dbReference type="GeneID" id="56595206"/>
    <dbReference type="KEGG" id="bps:BPSL1288"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.219"/>
    <dbReference type="OMA" id="PAYGGWW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="74" mass="8055" checksum="DC8E9521BDEFDA72" modified="2004-10-25" version="1">MNKTLVAAALASVALAGCYYPYGYYPASGYYAAPVQTAPVYVAPAYPAYYYPAPSLSLNFGYWSGGGRGYWRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VL3</accession>
    <name>Q63VL3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185619.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107853.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1231"/>
    <dbReference type="EnsemblBacteria" id="CAH35226">
        <property type="protein sequence ID" value="CAH35226"/>
        <property type="gene ID" value="BPSL1231"/>
    </dbReference>
    <dbReference type="GeneID" id="56595165"/>
    <dbReference type="KEGG" id="bps:BPSL1231"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.295"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EWIEVTQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17182" checksum="B1822426682D48E7" modified="2004-10-25" version="1">MTARVHALPVVASADALHARVGAAPFASGWIDIDQTRVDRFADATGDHQWIHVDPERAARESPFGGPIAHGFLTLSLIPALMTDALRFEQRMGVNYGLNRVRFLKPVPVGSRVRALFAVKGTGPAKQGGVQATWAVSVEVELGGQPVPACAAEFITLHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VV5</accession>
    <name>Q63VV5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204954.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107761.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1140"/>
    <dbReference type="EnsemblBacteria" id="CAH35134">
        <property type="protein sequence ID" value="CAH35134"/>
        <property type="gene ID" value="BPSL1140"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1140"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.401"/>
    <dbReference type="eggNOG" id="COG4695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NCLFHPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006427">
        <property type="entry name" value="Portal_HK97"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01537">
        <property type="entry name" value="portal_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="429" mass="46150" checksum="33302C189532703B" modified="2004-10-25" version="1">MRLLSWIRKAAPPVAVGGGNSIAGVVREPFAGAWQAGMGIDSRHDLLAFSAVYACVDRIASDISKLGIRYVKQIGNIWQDASAPRFTGPLRRPNPYQNRIQFVKAWQVSKLLAGNTYVLLVRDMLRNVTAMYVLDPARVIPLVAPSGAVFYQVAADPLRGVPGQVTIPASEIIHDRGICPWHPLIGVSPIVAAAAAGTMGNRIQQNSRKFFGNMSRPGGILSAPGKISDETANRLKTHWETNYGGENAGRLAVVGDGLKYETVMMTATDAQLVEQLRWAVEDVARCYHVPLYKIGADPTGSKTAANIGALEQSYYTDCLQAPIEELELCLDDGFEVPDGQGFDVDVRGLLRMDPAARYDAHSKAVGGGWMAPNEARAAENMPPVPGGDTPYLQQQNYSLGALAKRDKHPAPSSATLTSTSASKEPTNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VX0</accession>
    <name>Q63VX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LPS biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186441.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107746.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1124"/>
    <dbReference type="EnsemblBacteria" id="CAH35118">
        <property type="protein sequence ID" value="CAH35118"/>
        <property type="gene ID" value="BPSL1124"/>
    </dbReference>
    <dbReference type="GeneID" id="56595073"/>
    <dbReference type="KEGG" id="bps:BPSL1124"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.424"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTELWAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="254" mass="27822" checksum="0BBBD7B58100C67F" modified="2004-10-25" version="1">MAEPTLGVALIAYNAAARLAECLSALSFADDVIVVDGGSTDATVDIAKAHGARVIVAADWPGFGPQKNRAVSALDTDWILSVDTDEIVTPELAASIRAAIRAPRAPVYSLDRLSSFCGTWVRHSGWYPDWLPRLFKRGAARFSDDLVHERLVFDGPSAKLDGKLLHYSYEDFETVLRKLDAYSSAGAEQRRAAGKRGGLAKAFGRGAWAFVRTYVLRCGFLDGRAGFMIAVFNAETVYYRFLKLGLARQRKARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VZ3</accession>
    <name>Q63VZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538553.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107723.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1102"/>
    <dbReference type="EnsemblBacteria" id="CAH35095">
        <property type="protein sequence ID" value="CAH35095"/>
        <property type="gene ID" value="BPSL1102"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1102"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.453"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFQIMAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="154"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="36425" checksum="976BA9D0EFACD5E1" modified="2004-10-25" version="1">MPFIADSSRAALRGVLYVALSAVAFGAMAIFGRYAYAGGADVLGLLIVRFSIAGALLVAVARRRRVRWPRGRALAAIVGMGALGYVGQSLCYFSALQHAQASLVALLLYLYPAFVTLLAAWWLGERLTRAKAVALALCVAGSALMVGGGRGEPLGIALALGAAVVYSLYIVVGAKAARGVDPLATVAVICCAAAAMLAMLALARAAAFDAPPHWPRAAAGWAALVAIALVSTVAAMLAFFAGLARLGAARTSMLSTLEPVVTVALAAALFGETLTPLQWAGGVAILAAVLWLVRAGDAADSRGAGDDRERRRLGRRDDEPSAPGGSGAGGGLAGFVDPNECGIRRVRSADENARPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W09</accession>
    <name>Q63W09_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941330.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107707.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1085"/>
    <dbReference type="EnsemblBacteria" id="CAH35079">
        <property type="protein sequence ID" value="CAH35079"/>
        <property type="gene ID" value="BPSL1085"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1085"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.473"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PSLIQWD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="227" mass="24567" checksum="7A3E78D18FF66EA1" modified="2004-10-25" version="1">MAAHSLTLDHLVVAARTLEEGVAYVADTLGIEPAGGGAHPSMRTHNRLFGLWGRAYLEVIAAAPDAPAPADGQPRPRLFGLDDPATHARLEQGPYLAHWVARVDRPRELGLWQRQYPARIARVVPMTRGDFGWRLTVPDDGALPAWQGAGDGVLPSLIQWSDARHPCDALPHGDVALTALKAAHPRADTVREQLVWLNAAHLLELDAGETPALAAEFDTPRGARTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WC0</accession>
    <name>Q63WC0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192706.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107596.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0968"/>
    <dbReference type="EnsemblBacteria" id="CAH34964">
        <property type="protein sequence ID" value="CAH34964"/>
        <property type="gene ID" value="BPSL0968"/>
    </dbReference>
    <dbReference type="GeneID" id="56596224"/>
    <dbReference type="KEGG" id="bps:BPSL0968"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.609"/>
    <dbReference type="eggNOG" id="COG4654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGPALHD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267230" evidence="5">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="11170" checksum="02B03452D65225F6" modified="2004-10-25" version="1">MKRTTLRLTAFALVAAAANTQAQQADGLALAQRKNCMACHAIDKTLMGPSFHAIADKYAARGDAAGYLAQTIVKGSVGVWGNVPMPANTQLTSAEAGTLAHWILSSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WL6</accession>
    <name>KAD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <shortName evidence="1">AK</shortName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adk</name>
        <name type="ordered locus">BPSL0875</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185840.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107500.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WL6"/>
    <dbReference type="SMR" id="Q63WL6"/>
    <dbReference type="STRING" id="272560.BPSL0875"/>
    <dbReference type="EnsemblBacteria" id="CAH34867">
        <property type="protein sequence ID" value="CAH34867"/>
        <property type="gene ID" value="BPSL0875"/>
    </dbReference>
    <dbReference type="GeneID" id="56594750"/>
    <dbReference type="KEGG" id="bps:BPSL0875"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.721"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000158747" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <sequence length="220" mass="24170" checksum="1AC46DC4D7ECF64F" modified="2004-10-25" version="1">MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKTYMDEGKLVPDSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLVQRDDDKEETVKKRLDVYEAQTKPLITYYGDWARRGAENGLKAPAYRKISGLGAVEEIRARVFDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WU8</accession>
    <name>Q63WU8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="17">BCAT</shortName>
            <ecNumber evidence="17">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">ilvE</name>
        <name evidence="18" type="ordered locus">BPSL0793</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 17">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 17">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 17">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 17">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 17">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="17"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188924.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
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    <dbReference type="STRING" id="272560.BPSL0793"/>
    <dbReference type="EnsemblBacteria" id="CAH34785">
        <property type="protein sequence ID" value="CAH34785"/>
        <property type="gene ID" value="BPSL0793"/>
    </dbReference>
    <dbReference type="GeneID" id="56596573"/>
    <dbReference type="KEGG" id="bps:BPSL0793"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.812"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
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        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
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        <property type="project" value="RHEA"/>
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        <property type="term" value="F:L-valine transaminase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17 18" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17 18" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAH34785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="307" mass="33986" checksum="6E3A43B7EF9F4F6B" modified="2004-10-25" version="1">MSMADRDGKIWMDGKLIEWRDAKIHVLTHTLHYGMGVFEGVRAYKTADGGTAIFRLKEHTKRLLNSAKIFQMDVPFDQETLEAAQRDVVRENKLESCYLRPIIWIGSEKLGVSAKGNTIHVAIAAWPWGAYLGEEGLAKGIRVKTSSFTRHHVNVSMVRAKASGWYVNSILANQEATADGYDEALLLDVDGYVSEGSGENFFLVNRGKLYTPDLASCLDGITRDTVITLAKEAGIEVIEKRITRDEVYTADEAFFTGTAAEVTPIRELDNRTIGGGARGPITEKLQSAFFDVVNGKSAKHADWLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X32</accession>
    <name>Q63X32_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198678.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107334.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0705"/>
    <dbReference type="EnsemblBacteria" id="CAH34698">
        <property type="protein sequence ID" value="CAH34698"/>
        <property type="gene ID" value="BPSL0705"/>
    </dbReference>
    <dbReference type="GeneID" id="56596599"/>
    <dbReference type="KEGG" id="bps:BPSL0705"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.911"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NNLRGAE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266848" description="DUF4142 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="2">
        <location>
            <begin position="48"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="193" mass="20406" checksum="8BAD5D3AB46FBD13" modified="2004-10-25" version="1">MTRRSTFSLAGACAAALFAFATAASAQNAPAPTQPRPEAAADTRLHEADQAFVTDATKAVSTQRDAARIADSRSSDRAVKAFAARVAADNEKLSQALRAASPRGVDVPHNDPDPAVLDGIKNLRGDAFDKAYIEQVALDGNRKALSVFQAEIASGRNEQLKNAARKGLPVIQAHYQAAQELASRKHLTSDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XC0</accession>
    <name>Q63XC0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH crp-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189328.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107245.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63XC0"/>
    <dbReference type="STRING" id="272560.BPSL0616"/>
    <dbReference type="EnsemblBacteria" id="CAH34609">
        <property type="protein sequence ID" value="CAH34609"/>
        <property type="gene ID" value="BPSL0616"/>
    </dbReference>
    <dbReference type="GeneID" id="56593663"/>
    <dbReference type="KEGG" id="bps:BPSL0616"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1011"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YQIEVRL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="29068" checksum="C74C1C288A9BBAC3" modified="2004-10-25" version="1">MTYREYKEPATRAGGIIELPHRTDANRFLASLGVAERATLASHLQLVHVKSGQVLCEPGMALEHVYLPVTTVISIQYASSDGMTLEIAEIGNEGIVSPQLVGTDGASPCRVITCRDGFSYRLGARVLSNLLEESAQTRQAIFRCTHLLMAQAKQISFCSRHHVLKNQLCRWFLLAYDRSRSVEIQVTHSMLAQMLGVRRETVTDAAGDIQKMGLIRQYRSSIILVDLPGLDAQSCGCHAIIREEMKKIQAAPTSASGTLTELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XH0</accession>
    <name>Q63XH0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204824.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107195.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0569"/>
    <dbReference type="EnsemblBacteria" id="CAH34559">
        <property type="protein sequence ID" value="CAH34559"/>
        <property type="gene ID" value="BPSL0569"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0569"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1079"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VRDYFHV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="278" mass="30458" checksum="9766C0919A827ABA" modified="2004-10-25" version="1">MAYQAAIQRSDPTALLFLVDQSRSMEDRMAGSERTKAQFVADVLNRTLANLIVRCRKSDGVRDYFNVGVLGYGGDSVTNGFHGVLSQTTLQPISVVEANPLRIEERKRKVDDGAGGLVEQLTKFPVWFEPKADGGTPMRAAIMAAAEALAGWCDAHPRSYPPTVLHVTDGDSTDGDPEELADTLRQFQTDDGNVLLLNLHVSSQAGQPVQFPASENALADQYAKLLFRMSSQLPEHLVRVAQEKGIAASFESRGFMFNAEAEQIVNFFDIGTRPSQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XJ9</accession>
    <name>Q63XJ9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE type translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530934.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107166.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0541"/>
    <dbReference type="EnsemblBacteria" id="CAH34530">
        <property type="protein sequence ID" value="CAH34530"/>
        <property type="gene ID" value="BPSL0541"/>
    </dbReference>
    <dbReference type="GeneID" id="56527213"/>
    <dbReference type="KEGG" id="bps:BPSL0541"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1107"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMGWDCM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="204" mass="21394" checksum="32897DB10BBCE6DF" modified="2004-10-25" version="1">MPNFMLFLATSIAITVAPGPDNLQVLARGISQGRAAGIVAALGFASGVLFHTTLAAFGVAALLRSSPVAFHLLKLAGGAYLIWIGIKALRSKGLATAHARAPQPLSTIFRQSVIGNLLNPKVTLFFVVFLPQFVDPHGAQPVALQMLELGALFMAQTAAVFSVFGVGAGAIGVWLKRRPRVGVWLDRLAGATFVALGLRVALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XN2</accession>
    <name>Q63XN2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ordered locus">BPSL0507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195273.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107133.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0507"/>
    <dbReference type="EnsemblBacteria" id="CAH34497">
        <property type="protein sequence ID" value="CAH34497"/>
        <property type="gene ID" value="BPSL0507"/>
    </dbReference>
    <dbReference type="GeneID" id="56593827"/>
    <dbReference type="KEGG" id="bps:BPSL0507"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1142"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="546" mass="59870" checksum="D46DF61E1630928B" modified="2004-10-25" version="1">MKRNPAEKYRPFEPVRINGRRWPSRAIERAPIWMSTDLRDGNQSLIEPMTIEQKLEYFEMLVAIGFKEIEVGFPSASQTDFDFVRKLIVERRIPDDVTIEVLVQSREDLIARTFDALEGAPRAIVHLYNAICPSFRRIVFGMSKDDVKALAVDGTRIIKAHAQARPATHWTFQYSPETFSMTELPFAREVCDAVAQTWRPTRDHKMIVNLPATVEAATPNVFADQIEWMDRNLGYRDSIVLSVHPHNDRGTAVAAAELALLAGAERIEGCLFGNGERTGNVDLVTLALNLYTQGIDPGLDFSDIDAVRRVVERCNRIPVHPRHPYAGDLVFTAFSGSHQDAIRKGLAQQRPDAIWEVPYLPIDPADLGRSYDAVIRVNSQSGKGGATYLLERAMGFAPPRRVQIEFSHAVQTLADTSGAEVTADAICALFTREYLQTIGPAARAGASASWHDREVALAHAEDAPSAARQAAAAFASAAGVAIDITSCEVERTVNGETAVFVGARIGDAALRHGAGVHRDPVAAATDAVASAINRSAWSRDKRRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XN4</accession>
    <name>Q63XN4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipid A deacylase</fullName>
            <ecNumber evidence="2">3.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">LPS 3-O-deacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Outer membrane enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:136853"/>
            <dbReference type="ChEBI" id="CHEBI:140675"/>
            <dbReference type="EC" id="3.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PagL family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004553800.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107131.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0505"/>
    <dbReference type="EnsemblBacteria" id="CAH34495">
        <property type="protein sequence ID" value="CAH34495"/>
        <property type="gene ID" value="BPSL0505"/>
    </dbReference>
    <dbReference type="GeneID" id="56527249"/>
    <dbReference type="KEGG" id="bps:BPSL0505"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1144"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYTYWDG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050528">
        <property type="term" value="F:acyloxyacyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029681">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266856" description="Lipid A deacylase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="site" description="Critical for activity" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR029681-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="189" mass="20870" checksum="13C2461B2448474D" modified="2004-10-25" version="1">MNDKNGGRVGRAIARTALALALVGASGSAFADRWGLQLGGGVADHDMKKGDIAVVWDPNWTWWEIGGWHFAFVAEGHLSYWRYTGDRAINSSIWEVGATPIIRFIKSAGYVRPFVELGAGVRFLSHPTISQNYSMSTSFQFADMVGVGAQFGNRQQYQAGFRFQHVSNAGIKDPNPGINFSQLYVQYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XW0</accession>
    <name>Q63XW0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535336.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107055.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0430"/>
    <dbReference type="ESTHER" id="burma-q62f28">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34418">
        <property type="protein sequence ID" value="CAH34418"/>
        <property type="gene ID" value="BPSL0430"/>
    </dbReference>
    <dbReference type="GeneID" id="56527326"/>
    <dbReference type="KEGG" id="bps:BPSL0430"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1231"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQHFFIR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="259" mass="28454" checksum="8711AE5AFAD42670" modified="2004-10-25" version="1">MALLPGTLTIPDRREHARHRLLMFHHACGSATNYFRWAAAFAPHIEVWLVELPGRGRSLRHGAFDALPPLRDYLRELAPELPAEYSIFGHSMGALVAYCFAQDMMQLGRAPRWLGVSGADSPFAASRRRAFPVHQRPDAAIVEHLATLGGTPPEVFAHDELRAMLLQLAKADFRIVEAFFPLASATPLPVPVTVFAGAQDTVLSEGGLQDWQRASTLPIERETFDGGHFYLLDTPCAIHDAIGAALARHERQASVPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y47</accession>
    <name>Q63Y47_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550326.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106968.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0341"/>
    <dbReference type="EnsemblBacteria" id="CAH34330">
        <property type="protein sequence ID" value="CAH34330"/>
        <property type="gene ID" value="BPSL0341"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0341"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1339"/>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FIYMIVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="242" mass="25789" checksum="9E373BDDA8FB8873" modified="2004-10-25" version="1">MNSLPTSTVISEASPARSEAWRGLRASLPVMLGFVPFALVLGAQAAQKGLGIVEVPLLTGLNFGGGSEFTAIRLWTSPPHILLIVAMSFLVNCRHILMGAAFAPYLRHLSRRQTFPALFFMCDESWAMALADARREGRGRISLPYYLGVAAGLYLTWISCTALGAALGPTIGDVERYGFDMAFTAVFLVLLRGMWKGARASRPWLVSLVIAAATYLLVPGAWYVAAGALAGLVAAVVCGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YE0</accession>
    <name>Q63YE0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAH34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0248"/>
    <dbReference type="EnsemblBacteria" id="CAH34236">
        <property type="protein sequence ID" value="CAH34236"/>
        <property type="gene ID" value="BPSL0248"/>
    </dbReference>
    <dbReference type="GeneID" id="56594402"/>
    <dbReference type="KEGG" id="bps:BPSL0248"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1463"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NMPTFAH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="45640" checksum="07D0F047C47510B7" modified="2004-10-25" version="1">MASIAASTKTAGQVLNRRAVVAAVIGNALEWYDFTVFSFMTVVIAQLFFPTSSEYSSLLLTTATFGVAFFMRPIGGIVLGLYADRAGRKAALSLVILLMTFGIFLIAVAPPYAAIGIGGPLLIVLGRLLQGFSAGGEFGSATALLIEAAPLSRRGYYGSWQMASQAAALLFGSLVGAAVTRGLSTEALHAWGWRVPFLIGLVIGPVGFYVRRHLVDSEAFLQARERGEHVTLGEVFARHGRAVVCGLGAVIALTVTVYVLISYLPTFAVKQLKLPYAQSFYAVIIGNLLLTALSPVAGAWSDRIGRKGLSLWALGLTLVMIYPLFAWLDASPSIARLIAVQAMLSVTLAGYYGPFGAMIAELFPANVRSTGLSLAYNVAVMVFGGFGQFIVTWLIKTTGTPLAPTYYVMAGLALSLVALAFVPTERDALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YE2</accession>
    <name>Q63YE2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525882.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106873.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0246"/>
    <dbReference type="EnsemblBacteria" id="CAH34234">
        <property type="protein sequence ID" value="CAH34234"/>
        <property type="gene ID" value="BPSL0246"/>
    </dbReference>
    <dbReference type="GeneID" id="56527511"/>
    <dbReference type="KEGG" id="bps:BPSL0246"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1465"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGVSKAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="373" mass="39474" checksum="BC9A4111120849CC" modified="2004-10-25" version="1">MTIERIDCVVIGAGVVGLAIARELAARGRETLILEAADAIGTGMSSRNSEVIHAGLYYPRGSLKASLCLHGRDLLYDFCETHGVPHRRCGKLVVATSPAQAKQLKAIAARAEENGVLDLLTLSRDEVQALEPELECLEALFSPSTGIIDSHQLMLALLGDAERDGASCALRSPVESIDAAGGRFVVRTGGEAPAAIAAACVINSAGLDAQALAKRIRGLDSRWVPPLYLARGNYFSLSGRAPFAHLVYPVPDRAGLGVHLTLDLAGDARFGPDVEWIDALRYDVDPRRAESFCTSIRAYWPGLPEGSLRPAYAGIRAKVSGPGEPAADFVIQGTAQHGVRGLVNLFGIESPGLTAALAIAQRVGDMAARTRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YM7</accession>
    <name>Q63YM7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail completion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204761.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106788.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0160"/>
    <dbReference type="EnsemblBacteria" id="CAH34147">
        <property type="protein sequence ID" value="CAH34147"/>
        <property type="gene ID" value="BPSL0160"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0160"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1562"/>
    <dbReference type="eggNOG" id="ENOG5032RTF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GHPDSVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009678">
        <property type="entry name" value="Phage_tail_completion_R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06891">
        <property type="entry name" value="P2_Phage_GpR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="138" mass="15179" checksum="F4D592FF1E97AE0D" modified="2004-10-25" version="1">MNKPSSLRAALVAALPQLNASPDQLLVFVNEGRIEATGTRTASFDYEYECEIIIRDFIGNPDDVMVAVVEWARANQPDLVMNRDERRDGMTFVADILSNNAVDLGLKVKLSESVVVGTDEAGNRTVEHIDDAADEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YT6</accession>
    <name>Q63YT6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204744.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106729.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0103"/>
    <dbReference type="EnsemblBacteria" id="CAH34087">
        <property type="protein sequence ID" value="CAH34087"/>
        <property type="gene ID" value="BPSL0103"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0103"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1627"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTRMREC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="482" mass="52285" checksum="39CF0B95EB06B71D" modified="2004-10-25" version="1">MKVSARELRYEQGIDRLLELAGARDDTEYADVADEFASAPSSAFAHDLGEPDSLDHQASDESAGAGSFGDKPTRPAHGDTDVDTDWRDDDAPPSGSNDAAPVDTAASTDPLALFVRRMHAVPLLTHAQEIALAAEIEAGREQVLQALAEALDRLDLASLPADPALGRARAALQRARARGDEGARAFARARTAAYAALAAHGWPSAEVDAVRRAMRRLPTSPEKSDAGAQRAFADGEARISAATARMAEANLRLVLSIARKYASRGLDLADLLQEGNLGLLRAIEKFEHRRGFKFSTYATWWIRQAISRAIADRARTIRVPVHVGDEARRVRKAADRIERRSGVNASLAELSEATGLPAERLRAVLTLPREPRSLNAPLGDDDQAEFGDIVEDTSTPSLFDALAHGQMCDVVTSLLKTMSAQEADILRRRFGIGGDEPWSYEQIAARAGVSREQVRRIEKRALQTLRVTAEACNAHDFLDVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z02</accession>
    <name>Q63Z02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106663.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0038"/>
    <dbReference type="EnsemblBacteria" id="CAH34021">
        <property type="protein sequence ID" value="CAH34021"/>
        <property type="gene ID" value="BPSL0038"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0038"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.38"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSWIFAS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="285" mass="30671" checksum="D5D34D4B353F9F80" modified="2004-10-25" version="1">MTDMTLPTPLGTLTSLEDEERAAQRRLRRRRQLIVGLRIAVLVAVLGGWEIAARLKWIDPFFFSMPSLIAAQIQDWFVNGTSQGPLLLQVWVTLEETIAGFLIGSVAGIFCGIVLGRNKLLADVFGLYIQIANSIPRVVLGSVFVIALGLGMASKIALAVVMVFFVVFGNAFQGVREADRYLIANAQILGASRRQITTSVVIPSALSWILASLHVSFGFALVGAVVGEFLGSKQGIGLLISTAQGAFNASGVFAAMIVLAVVALAADFLLTRLEKRLLKWRPAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-10-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V7S8</accession>
    <name>Q3V7S8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ordered locus">BPSL2624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527563.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109220.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2624"/>
    <dbReference type="EnsemblBacteria" id="CAH36632">
        <property type="protein sequence ID" value="CAH36632"/>
        <property type="gene ID" value="BPSL2624"/>
    </dbReference>
    <dbReference type="GeneID" id="56528575"/>
    <dbReference type="KEGG" id="bps:BPSL2624"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2729"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PYIILKW"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAH36632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="378" mass="40598" checksum="A9E543C4622052DC" modified="2005-10-11" version="1">MFSESDFTHMQRALALAARGMYTTTPNPRVGCVIVKDDVVIGEGFTQPAGQDHAEVQALKDARARGNDLRDATVYVTLEPCSHFGRTPPCAHTLIDARVGKVVAAMEDPNPQVSGRGLAMLRDAGIDVRCGLLAHEAHEMNIGFVSRMTRGRPWVRMKTAASLDGRTALASGESKWITGDAARDDGHKWRARACAILTGIGTVREDDPQLNVRGVDTPRQPRRVLIDSRLDIPLAARLLEGGSLLVFCGALDAQSEPRADALRARGAEIVPLANARGKVDLPAMLAALGERGINELHVEAGHKLNGSLLRERCVDELLVYLAPSLLGADAAAMFDLAAPASLVDRTRLAFHSVERVGDDLRILARFANAHASASPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HS8</accession>
    <name>Q63HS8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190237.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112344.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2342"/>
    <dbReference type="EnsemblBacteria" id="CAH39828">
        <property type="protein sequence ID" value="CAH39828"/>
        <property type="gene ID" value="BPSS2342"/>
    </dbReference>
    <dbReference type="GeneID" id="56598456"/>
    <dbReference type="KEGG" id="bps:BPSS2342"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5981"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SWENRPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="179"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="34943" checksum="B663C3F6569D0672" modified="2004-10-25" version="1">MNLLSSLSDLVIERVSFGIFVLDREMRVLMWNRFMQDHSGVAAADVIGRNLFDSFPELPRAWLSRKIESVFQLGSFAFSSWEQRPYLFRFDHDRPITGGVDFMQQDCTFVPIARAREVEAVCVTVSDVTHVSVMQREREEAVAKLQEYANRDGLTGIANRRFFEARLRDEFSRWQRYGGNLSVLLFDLDHFKTINDRFGHVVGDNVLRVMAQRVADVVRSQDTFGRFGGEEFALLLPCTSLDEAMLVAEKIRQTIGSTPIEAEGVRVPVTASVGGAAAHAGALTHETLVNEADAALYRAKRQGRNCSVAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HX6</accession>
    <name>Q63HX6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188311.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112296.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2293"/>
    <dbReference type="EnsemblBacteria" id="CAH39779">
        <property type="protein sequence ID" value="CAH39779"/>
        <property type="gene ID" value="BPSS2293"/>
    </dbReference>
    <dbReference type="GeneID" id="56598402"/>
    <dbReference type="KEGG" id="bps:BPSS2293"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5914"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGLYNTK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="11"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="327" mass="34441" checksum="874FBEECC8765DBC" modified="2004-10-25" version="1">MAHAIRFHETGGPEVLRREETQVGAPGPGEVRVRHAAVGLNFADIYFRTGLYPAKLPSGIGVEAAGIVTAVGGNVAGLAVGERVTYTGSPLGAYSTERVMPADSLIRLPDAIGFDTAAAMTMRGLTSAYLMRRIHAWQAGDTFLLHAAAGGVGLIVCQWAKLLGLNVIGTVSSDEKADIARAHGCDHVIVHRREDVAKRVRELTNGVGVAVVIDSVGKSTFAASLDSLKRRGLLVGVGTASGPFPPIDAMQLAIKGSLFFTRPALADYIADPAEKAALAGELFDHVAAGRIRIEINQRYELNDAVQAHRDLEAGRTTGSSIFVVDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HZ9</accession>
    <name>Q63HZ9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdV</name>
        <name evidence="16" type="ordered locus">BPSS2270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004537996.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112273.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2270"/>
    <dbReference type="EnsemblBacteria" id="CAH39756">
        <property type="protein sequence ID" value="CAH39756"/>
        <property type="gene ID" value="BPSS2270"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2270"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5880"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IHAAEEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="9"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="347"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAH39756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="466" mass="48617" checksum="C3DB335B3390D657" modified="2004-10-25" version="1">MSDTKTTTLLVIGGGPGGYVAAIRAGQLGVRTILVERDRLGGTCLNIGCIPSKALIHAAGEFDKVRGFAGDSPLGIRTQAPAIDIARTVAWKDGIVKKLTGGVGALLKKNGVEVVHGDARVVDGKTVDVDTGGGARVRIQCEHLLLAAGSEPVELPAMPFGGNVISSTGALSPGRLPKRLVVVGAGYIGLELGIAYRKLGVEVSVVEARERILPIYDAELTKPVAASLKRLGVRVLLGHKVLGLNARGDAVCVQDDAHAQTELAADQVLVTVGRRPRTQGWGLETLQLDRAGAALKIDDMCRTSMRNVWAIGDLTGEPMLAHRAMAQGEMVAEIVAGKKRHFMPAAIAAICFTDPEVVSVGLAPDEAERTFGACVSASFPFAANGRALTLESADGFVRVVARRDDHLIVGWQAVGAGVSELAAAFSQSLEMGARLEDVGGTIHAHPTLGEAVMEAALRALGHALHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF1</accession>
    <name>Q63IF1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009941168.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112121.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39603">
        <property type="protein sequence ID" value="CAH39603"/>
        <property type="gene ID" value="BPSS2122"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2122"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5671"/>
    <dbReference type="OMA" id="NVERMWM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="132" mass="13808" checksum="59DEE1D9747E49FD" modified="2004-10-25" version="1">MTPDGCSDGCRRRAVRGGVDGLGVSVLAAMHGVSLSIATFSKNGGAVTVSGGAGDGGDIGMPSSDVAEERAPPNEVFGGVFGVEEMAIDACRLPEMKWRNVERMWMKPVPLRVRSMRDRSAVRLAGGVRCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG1</accession>
    <name>Q63IG1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190854.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112111.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39593">
        <property type="protein sequence ID" value="CAH39593"/>
        <property type="gene ID" value="BPSS2113"/>
    </dbReference>
    <dbReference type="GeneID" id="62648147"/>
    <dbReference type="KEGG" id="bps:BPSS2113"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5659"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="58" mass="6103" checksum="24C1531C3880787B" modified="2004-10-25" version="1">MKLVEPGKPDVSYGLHKLKGSQASVGGKGGAMPFGEPRAARERVDALERWIGNGAPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IM2</accession>
    <name>Q63IM2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chrolohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS2047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539274.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112050.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2047"/>
    <dbReference type="EnsemblBacteria" id="CAH39525">
        <property type="protein sequence ID" value="CAH39525"/>
        <property type="gene ID" value="BPSS2047"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2047"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5581"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CYEVSDR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="60"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="477" mass="50487" checksum="CFE60FA5E21705AC" modified="2004-10-25" version="1">MGATTLITGGIVVCGDDAGTVITDGAVLVDGNCIADVGDTAAVATRHPAPDRILDAAGKIVAPGFVSSHNHLGFVLFRGMAEDVGATPTPTMFLPMRALVTTHERIVFARLGVLELLRGGVTTILAMEEDATAIAPVLVESGMRARIALMTNDVDVPSLLEGKTAFDPNLTRHALRQSEELIVQWPGGASERIGAMIGANMMLSCSDALLRGLGELAARHGVGVTCHVGLGDYEVELSHALYGKGPFALLRDVGFLESDCVAAHCHHVADDDLAILRKAKAAVAHCPVLSALRGAAAPVQRMIDEGLSVALGLDNYFADCFDAMRMYVSVARMRERDATLFRSRDALRAATLDAARALHMDDQIGSIEIGKKADIQLIDVTRPGIVPIIDPVGTLVYHAHAGDVSTVLIDGVVVLLDGRVIPIDEPTALEEGQRLGALAWHRFAAHYPEKLGVLQWTPDSIPNLSAAWRSTASGANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IQ5</accession>
    <name>Q63IQ5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524909.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112017.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2014"/>
    <dbReference type="EnsemblBacteria" id="CAH39492">
        <property type="protein sequence ID" value="CAH39492"/>
        <property type="gene ID" value="BPSS2014"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2014"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5532"/>
    <dbReference type="eggNOG" id="ENOG50317KD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMHADDA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="330" mass="34618" checksum="092434649B80FB16" modified="2004-10-25" version="1">MTTFNVMMPVAGVLALPFLPLLNELVRRSDVDALPIGEGPCVDYPRRAAQWLDALRASARGAPPAPDDAPPPWQALGLRVEHVDALRLARGDRRDGVLYADHTISLGAGAHAAYAFAEERLEMRAGATLGGFAYAPNVDIDNTLVRGAVVGQAVRVHGCGGFANLHGTPIVFGRLAHAPGRDAALTPRRAMSLSGRLAGVPHRVLGGRYLVARDIRLPSHTILHGTLIVDGRLTLGEGCVLIGSVKAHSVVLECDALLNGAVFARDDVLLDEASCIDGVVSAGGLLRLTGARIGAADHPVSACARDVSVVGHACVHGDLVAWRSGWYHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J00</accession>
    <name>Q63J00_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetyl-CoA reductase</fullName>
            <ecNumber evidence="3">1.1.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phbB</name>
        <name evidence="3" type="ordered locus">BPSS1916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.36" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530255.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111922.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63J00"/>
    <dbReference type="STRING" id="272560.BPSS1916"/>
    <dbReference type="EnsemblBacteria" id="CAH39394">
        <property type="protein sequence ID" value="CAH39394"/>
        <property type="gene ID" value="BPSS1916"/>
    </dbReference>
    <dbReference type="GeneID" id="56529666"/>
    <dbReference type="KEGG" id="bps:BPSS1916"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5393"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHAFEVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018454">
        <property type="term" value="F:acetoacetyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011283">
        <property type="entry name" value="Acetoacetyl-CoA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01829">
        <property type="entry name" value="AcAcCoA_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="26429" checksum="42DE5B06028AF414" modified="2004-10-25" version="1">MQAKRVAFVTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAVDVADFESCERCAEKVLADFGKVDVLINNAGITRDATFMKMTKGDWDAVMRTDLDAMFNVTKQFIAGMVERRFGRIVNIGSVNGSRGAFGQANYASAKAGIHGFTKTLALETAKRGITVNTVSPGYLATAMVEAVPQDVLEAKILPQIPVGRLGQPDEVAALIAFLCSDDAGFVTGADLAINGGMHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J24</accession>
    <name>Q63J24_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Catechol 1,2-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">catA</name>
        <name evidence="11" type="ordered locus">BPSS1892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>catechol + O2 = cis,cis-muconate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23852"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:32379"/>
            <dbReference type="EC" id="1.13.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.1" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525033.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111898.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1892"/>
    <dbReference type="EnsemblBacteria" id="CAH39370">
        <property type="protein sequence ID" value="CAH39370"/>
        <property type="gene ID" value="BPSS1892"/>
    </dbReference>
    <dbReference type="GeneID" id="56529690"/>
    <dbReference type="KEGG" id="bps:BPSS1892"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5358"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IATYDNY"/>
    <dbReference type="UniPathway" id="UPA00157">
        <property type="reaction ID" value="UER00258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019614">
        <property type="term" value="P:catechol-containing compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03460">
        <property type="entry name" value="1_2-CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012801">
        <property type="entry name" value="Cchol_dOase_prob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02439">
        <property type="entry name" value="catechol_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="10">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH39370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="300" mass="32967" checksum="4AFE19E5E054E30D" modified="2004-10-25" version="1">MNKEAIDALLKSFDDAATRPGNPRVRAIVNRIVKDLFYTIEDFDVQPSEFWTALNYLNDAGKEFGLIAAGLGFERFLDVRMDEAEAKAGLQGGTPRTIEGPLYVAGAPESVGHARLDDGTDPGETLVMRGRVLGGNGAPLANALVEVWHANHLGNYSYFDPSQPAFNLRRSIRTDAEGRYSFRSVLPVGYSVPPGSKTEQLLDQLGRHGHRPAHIHFFVSAPGHRKLTTQINIEGDPHIWDDFAFATREGLIPKIAQAEGAQGKPYGIDGRFALIDFDFTLTRERGDVPASEVERVRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI6</accession>
    <name>Q63JI6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525171.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111736.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1730"/>
    <dbReference type="EnsemblBacteria" id="CAH39205">
        <property type="protein sequence ID" value="CAH39205"/>
        <property type="gene ID" value="BPSS1730"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1730"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5151"/>
    <dbReference type="eggNOG" id="ENOG5032WE0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRWVSAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021218">
        <property type="entry name" value="DUF2784"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10861">
        <property type="entry name" value="DUF2784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="123" mass="13739" checksum="D8B6A9E2E0EABE3A" modified="2004-10-25" version="1">MTWLADIVLVVHALLVLFIVGGLAAIWTGAALGWRWVRARTFRLAHLLAIGIVAALAALGIDCPLTVLEDRLRTGAPDAQGFVQRWVGRLLYHDLPAWAFTVAYVLFALLVWLTWRRIPARDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JK0</accession>
    <name>Q63JK0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD assembly factor SdhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SdhE FAD assembly factor family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528990.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111722.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1716"/>
    <dbReference type="EnsemblBacteria" id="CAH39190">
        <property type="protein sequence ID" value="CAH39190"/>
        <property type="gene ID" value="BPSS1716"/>
    </dbReference>
    <dbReference type="GeneID" id="56529873"/>
    <dbReference type="GeneID" id="66549450"/>
    <dbReference type="KEGG" id="bps:BPSS1716"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5133"/>
    <dbReference type="eggNOG" id="COG2938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRARLRW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="SSF109910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="90" mass="10470" checksum="38BA8FB089113E1A" modified="2004-10-25" version="1">MSESSHQSDPHRRARLRWRARRGLLENDLIFERFFARHEHDLSDADVSALSRLLDLSDNDLMDLLLARKEPEGDLAGPDMSRLLEMLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ7</accession>
    <name>Q63JQ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111665.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1659"/>
    <dbReference type="EnsemblBacteria" id="CAH39133">
        <property type="protein sequence ID" value="CAH39133"/>
        <property type="gene ID" value="BPSS1659"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1659"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5950"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="95" mass="10354" checksum="3A96591F3167A011" modified="2004-10-25" version="1">MRRGTLPDDRRGEVCAVSVSIGAGAAGDVSPQLRQRHLSPVELTQAMLARIAQLDVHLNAYIRVTAESALADARCAEQEIARGINRDRCMASRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JT3</accession>
    <name>Q63JT3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201198.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111639.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1631"/>
    <dbReference type="EnsemblBacteria" id="CAH39106">
        <property type="protein sequence ID" value="CAH39106"/>
        <property type="gene ID" value="BPSS1631"/>
    </dbReference>
    <dbReference type="GeneID" id="56597983"/>
    <dbReference type="KEGG" id="bps:BPSS1631"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5018"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TGAEVWF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="317" mass="35102" checksum="C6C419B4EAF5E6F9" modified="2004-10-25" version="1">MNVQPLFGQAQHHPVVVTPRGDASLHALRDYLADDAEGVARLLREHGGVLFRGFGLNGADDFRAITECLGAKPFGYVGGDSPRSRVAPGVYTSTDHPASERISLHNEMSYLPAYPRRLFFYCLVPAASGGQTPLAHGGDVLRAVPADIVERLSRNRINYVRNFPAVRLGKSWQDTYQTNDRAEVERIAAEQGSTCAWLPQGLRVTTPCDAIVTHPRTGDALWFNQAELWHPSALAPRLRSTFEQLVGKGNLPHECEYGNGEPIGADVLAEIRRALQANKLMFDWRRGDLLMIDNLTMMHGREAFRGERKTLAYLSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K58</accession>
    <name>Q63K58_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4150 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200966.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111514.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1507"/>
    <dbReference type="EnsemblBacteria" id="CAH38980">
        <property type="protein sequence ID" value="CAH38980"/>
        <property type="gene ID" value="BPSS1507"/>
    </dbReference>
    <dbReference type="GeneID" id="56597760"/>
    <dbReference type="KEGG" id="bps:BPSS1507"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4854"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NTGVNKM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025425">
        <property type="entry name" value="Tox_PAAR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13665">
        <property type="entry name" value="DUF4150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4150" evidence="1">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="13108" checksum="308DEA7C4521344B" modified="2004-10-25" version="1">MFAVTTASGLCLSPADVCKTPTPGGPVPVPYPNTGLPMMAASITTKVLVCGMPALTKKSTIPMTNGDQPGSAGGVMSAKIMGKVEFTAGSAKVKFEGGAAVRLTTPTKHNEGNATGAVLQPSQQKVMVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE1</accession>
    <name>Q63KE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hyi</name>
        <name evidence="4" type="ordered locus">BPSS1419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524357.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111431.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1419"/>
    <dbReference type="EnsemblBacteria" id="CAH38894">
        <property type="protein sequence ID" value="CAH38894"/>
        <property type="gene ID" value="BPSS1419"/>
    </dbReference>
    <dbReference type="GeneID" id="56530161"/>
    <dbReference type="KEGG" id="bps:BPSS1419"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4743"/>
    <dbReference type="eggNOG" id="COG3622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CEYRPRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="258" mass="28733" checksum="60F588A8B08AB532" modified="2004-10-25" version="1">MPRFAANLTMMYNEHAFLERFAAAARDGFKAVEYLFPYEFPAAELKARLDAHGLVQALFNAPPGDWAAGERGIASLPGREDEFRRAIDTALDYARVIGNDTLHVMAGLIAPTQDRARHRDVYLRNLAHAAEAARAQNVTIVIEPINPRDMPGFFLNRQDDAQAICREVGAPNLLVQFDCYHCQIVEGDLAMKLKRDIAGIGHIQIAGVPQRHEPDVGEIHYPYLFELIDALGYDGWIGCEYRPKAGTSEGLGWLAPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP2</accession>
    <name>Q63KP2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524257.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111329.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1319"/>
    <dbReference type="EnsemblBacteria" id="CAH38790">
        <property type="protein sequence ID" value="CAH38790"/>
        <property type="gene ID" value="BPSS1319"/>
    </dbReference>
    <dbReference type="GeneID" id="56530261"/>
    <dbReference type="KEGG" id="bps:BPSS1319"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4615"/>
    <dbReference type="eggNOG" id="COG5470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYTQRAP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="98" mass="10899" checksum="E514EF957EFE5FD9" modified="2004-10-25" version="1">MAAYLLGRMAISDPSKYARYKALTPDIIARYGGRFLTRGGEKLTLEGPADERRIVLVEFADADAAARFYHSADYQHAKSLREGAADMQLMIVGGFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KT8</accession>
    <name>Q63KT8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536930.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111283.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1276"/>
    <dbReference type="EnsemblBacteria" id="CAH38743">
        <property type="protein sequence ID" value="CAH38743"/>
        <property type="gene ID" value="BPSS1276"/>
    </dbReference>
    <dbReference type="GeneID" id="56530307"/>
    <dbReference type="KEGG" id="bps:BPSS1276"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4550"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="134"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="196" mass="21178" checksum="A636341A5AB0C7C6" modified="2004-10-25" version="1">MTYTLAATYTRELDIRKSRFIAYAIPVEDRDAAMAELQRLRAEHPGATHVCWALLAGGQSGMSDDGEPSGTAGRPILEVLRHHDLDGVLGAVVRYFGGVKLGAGGLVRAYTDAIAAALIDAERVERIAYARLAIEIGYPDEARVRRWIEQEGHALVDSAYAMTVKLVIRLPAAAADAARDTLFDLTQGRAGFPSVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L05</accession>
    <name>Y5206_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKHD-type hydroxylase BPSS1206</fullName>
            <ecNumber evidence="1">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">BPSS1206</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528491.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111216.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63L05"/>
    <dbReference type="SMR" id="Q63L05"/>
    <dbReference type="STRING" id="272560.BPSS1206"/>
    <dbReference type="EnsemblBacteria" id="CAH38673">
        <property type="protein sequence ID" value="CAH38673"/>
        <property type="gene ID" value="BPSS1206"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1206"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4444"/>
    <dbReference type="eggNOG" id="COG3128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPPLFNC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00657">
        <property type="entry name" value="Hydroxyl_YbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041097">
        <property type="entry name" value="PKHD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023550">
        <property type="entry name" value="PKHD_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41536">
        <property type="entry name" value="PTHR41536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18331">
        <property type="entry name" value="PKHD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0847">Vitamin C</keyword>
    <feature type="chain" id="PRO_1000061715" description="PKHD-type hydroxylase BPSS1206">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00657"/>
        </source>
    </evidence>
    <sequence length="227" mass="24808" checksum="C927C3AE6DFBD947" modified="2004-10-25" version="1">MMLHIPGVLTKEQVAQCRDILDAADWTDGNATSGAQSALAKRNRQLPEGSPAARAAGDAIQDALACNALFFSAALPLKVFPPLFNRYAGGDAFGTHVDNAIRLLRGTDFRVRSDLSATLFLEEPEHYDGGELCVEDTYGVHRAKLPAGDMVLYPASSLHHVTPVTRGARVASFFWIQSMVRDDADRTLLYQLDTQIQRLTAEKGGRDASVIALTGIYHNLLRRWADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L06</accession>
    <name>Q63L06_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551718.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111215.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1205"/>
    <dbReference type="EnsemblBacteria" id="CAH38672">
        <property type="protein sequence ID" value="CAH38672"/>
        <property type="gene ID" value="BPSS1205"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1205"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4443"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LDWGLYN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="26472" checksum="F7BBC9464BF31E3E" modified="2004-10-25" version="1">MGRAVSLKALAAASREDLAGILAGAPERAAAWVAAAAQNGIVEAQAVYGQYLLDGHGVARDAAAALEWFKHAARADHPMAMNMVGRCYEFGWGTAASAAVAVYWYREAARAGLDWGMYNYATMLALGNGVDEDRAAALAWFEKAAALGHAKSINLIGGFHEDGWVVAADRDAAFDCYRRAAAAGDFRGQFNYARLLAERGRVAEALEWLARVPRTATPAFVAKMRAYLAASPIDAFRALAARQEKSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L32</accession>
    <name>Q63L32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acyl-homoserine lactone dependent regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004558040.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111189.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1176"/>
    <dbReference type="EnsemblBacteria" id="CAH38644">
        <property type="protein sequence ID" value="CAH38644"/>
        <property type="gene ID" value="BPSS1176"/>
    </dbReference>
    <dbReference type="GeneID" id="56530410"/>
    <dbReference type="KEGG" id="bps:BPSS1176"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4407"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MICSITE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005143">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036693">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03472">
        <property type="entry name" value="Autoind_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75516">
        <property type="entry name" value="SSF75516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="234" mass="25714" checksum="9E702266194A24F9" modified="2004-10-25" version="1">MHDFLQFWLNEFSRSENPQHVISVLTRAAATLGYEYAAYGMRRPFPISNPPILMVSNYPARWQERYIEARFANIDGAVKAALGSDRPVTWSAPANASKSAFWAEALSFGIAHGWSSASRGADGAIGVLTLSRTQDPIDTAEKFRNESIVHWLANVAHASMAPFLPAADEFDPDLTRRETDVLKWTADGKTAYEIALILSISESTVNFHVKNIVSKLGSTNKIQAVAKAALMGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LI3</accession>
    <name>Q63LI3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative sugar ABC transporter ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205510.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111038.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1032"/>
    <dbReference type="EnsemblBacteria" id="CAH38493">
        <property type="protein sequence ID" value="CAH38493"/>
        <property type="gene ID" value="BPSS1032"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1032"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4217"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="321"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH38493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="604" mass="62384" checksum="2FD1704167A07272" modified="2004-10-25" version="1">MKAALTTAAASAAAAPDAAGAPLALDVRRVVKRFGGVAALRGASLAVTRGTVHGLIGQNGAGKSTLVKLLAGLHAPDEGEITVGGVPFASGGGGSRASAGAARRHSTGIGFIHQERLLPATFTVAEALFFPHPPTLGGRASRLARLLPLDVKRMRRDCRAVLHTQFGLDLAPDRLIGELSVAEQQIVQITRALLGRHEILVFDEPSAALVSSEVDRLLRTIERLRANGHTILYVSHYLDEIARVCDRVSVLRDGADVAHFEARAVSRDTLVAAMIGAPQPAAAAPSAATARADARVSARANAWGDDPHRAPAGADPARPGARAAPGAIALEARDLALPGRFGPLSLAVRRGEIVGLTGGLGSGGKDVIRALFGLARGVRGSIAVDGRPARVRRPHDAVAHGIALVPENRAAHGVALTLPVRENVVLADLSSVSRFGLVHGRREADVARALIRRLDIRPARPDLPARFLSGGNQQKVALAKWLGRASTVYLLDEPTVGVDVGAKAQIYRLIDALARAGAAVLLFSSDLTELLDVTDRVYVMARGEIVAQCASAETTTRDVLAWATLARDARPGGGAGAHDAAARTGTPGAAGAAGAASSAAKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LR0</accession>
    <name>Q63LR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dipeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199680.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110961.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0953"/>
    <dbReference type="EnsemblBacteria" id="CAH38415">
        <property type="protein sequence ID" value="CAH38415"/>
        <property type="gene ID" value="BPSS0953"/>
    </dbReference>
    <dbReference type="GeneID" id="56597316"/>
    <dbReference type="KEGG" id="bps:BPSS0953"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7264"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FIITARV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="117"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="38560" checksum="241535B8E80BB59A" modified="2004-10-25" version="1">MSLPAPPLETPRTLPARRPGVRWALRALRWTLTLAVTFAGLLALTFVIGRKVPIDPVLAVLGDRASAAAYAAERIALGLDKPLATQFLIYARDVLHGNLGMSLLTSNPVLDDIRRVFPATLELATLATLIGVALGVPLGVAAAVKHNRPIDHVARFVGLIGNSVPVFWLGLMGLLLFYARLHWVAGPGRLDPVYDGMVDPRTGSLLLDAALAGEWDVLRNALSHIALPAAILGYYSVAYLSRMTRSFMLDQLNQEYIVTARAKGLAERRVIWRHAFGNIAVPLLTVIALTYSNLLEGSVLTEIVFAWPGIGSYLTGALLNADMNAVLGCTLVIGVMFITINLLTDALYRVFDPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LW6</accession>
    <name>Q63LW6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske [2Fe-2S] domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551580.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110905.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0896"/>
    <dbReference type="EnsemblBacteria" id="CAH38358">
        <property type="protein sequence ID" value="CAH38358"/>
        <property type="gene ID" value="BPSS0896"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0896"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4993"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WERDVWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="40424" checksum="05D9A02DB539E8FE" modified="2004-10-25" version="1">MTSSDQTNSGADPVRAYLDCGIRNYWYPVAPSWQVSSAPVGITRLSEQIVLWRDREGNVHALEDRCPHRGARLSLGWNLGDRVACWYHGVEVNGGGTVTKVPAVSNCPLEGQACVKSYPVEERAGAIFLWFGDDAHREPAPLVLPDELVAPEYAQFVCVSNWTCNYQYAIDNVMDPMHGAYLHATSHSMAEGDKQADMRVRRTETGLMFEKVNQRDVNFDWVELGETGCIWLRLAIPYQRKFGPGGSFGIVGFATPIDDEHCQVYFWRTRKVAGWQRDVWRFLYRNRLEGLHWAVLEQDRYVLESMAPNARDHEYLYQHDIGVTRVRRMLRQRAQEHLAALDAHRAAQADAAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MG6</accession>
    <name>Q63MG6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523778.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110705.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0691"/>
    <dbReference type="EnsemblBacteria" id="CAH38151">
        <property type="protein sequence ID" value="CAH38151"/>
        <property type="gene ID" value="BPSS0691"/>
    </dbReference>
    <dbReference type="GeneID" id="56530859"/>
    <dbReference type="KEGG" id="bps:BPSS0691"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6905"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KMQQLTA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012712">
        <property type="entry name" value="HpaR/FarR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02337">
        <property type="entry name" value="HpaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="145" mass="16662" checksum="371DFD9B6B372A5D" modified="2004-10-25" version="1">MNRTFDHRNLAMLLLEARETLMGRFRPILKEFALTEQQWRIIRVLDGEPSHELEAGQIAKRCCILSPSLTGVLERMERDGLIRRTRAQEDQRRLIVSLTPQSCQLVTQISPRIDEQYRLIEQRFGADALGEVYAALDKLIDVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MK3</accession>
    <name>Q63MK3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194586.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110668.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0649"/>
    <dbReference type="EnsemblBacteria" id="CAH38106">
        <property type="protein sequence ID" value="CAH38106"/>
        <property type="gene ID" value="BPSS0649"/>
    </dbReference>
    <dbReference type="GeneID" id="56597662"/>
    <dbReference type="KEGG" id="bps:BPSS0649"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6846"/>
    <dbReference type="OMA" id="NACPPRM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="16390" checksum="5474CF8B6C135D67" modified="2004-10-25" version="1">MNALAGKARGLSLSVANAHIAAAHVEKMPEANTHAAAAHVADAHDTNAFSNARPPRMLTVSIRLERTRAYSNPPDEHAPPTLEQQASLATRPAANKPSRSCAFPMHRRNGIPAAIGNAGCAGRAAIRAFGVRLRTAQRPLELHRTTPNAFPMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MR0</accession>
    <name>Q63MR0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable ATP-binding component of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pchI</name>
        <name evidence="14" type="ordered locus">BPSS0590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551424.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110611.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0590"/>
    <dbReference type="EnsemblBacteria" id="CAH38047">
        <property type="protein sequence ID" value="CAH38047"/>
        <property type="gene ID" value="BPSS0590"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0590"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6766"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MQVPGQL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="321"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH38047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="594" mass="62468" checksum="9B3E03DF8C7E09C3" modified="2004-10-25" version="1">MTAWLKRWRCLPADTRRSLVRGVGWAVAAALLDGLCGVLLVPLIRAWFAGGALLHWAAALIALTLGHALVLYAAQLGGYRAGGALALGLVDRLVRHLPRIAAPQTVRDSDPEGLLRGPVMQAMGIPAHLLGPLIGAVVTPLAVVAGLAAIDWRIALCLAAAAALLFALLNRSGARTLALEEARAAGERDLAEQLQAFAAHQGLLRFAGRDGSGRAALQRALDERHRRARALMRRSLPLELGFAGAVQAVFVAMLVGGAAAVAAGRLDPATVVAVLVLLVRFIEPLAQLTQLDQALRGGWRALDAVLTVLHAPRFESPERGLRPQDASVAAVRVGYRSETGATLLDDVDLHCPAGGFVAIVGPTGAGKSTLLGLLARLDDPSSGRVLFGNVDLRRLSETTLAGARTVVFQHSGLFRGSLGWNLRMGRPDASGAALDAVLDALGLSRDVERLPHGLDTDVGPGGQLLSGGQRQRACIARGLLAKAPLLLLDEPTASLDELSARRVRDCLVAMRGQRTRIVVTHHPALARAADEIVVLEAGRVRARGTHAQLVAADPWYAEFARAESECEREPEVETPATAIAGISAPARGADAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MY9</accession>
    <name>Q63MY9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate mutase</fullName>
            <ecNumber evidence="3">5.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS0509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.9" evidence="3"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110530.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0509"/>
    <dbReference type="EnsemblBacteria" id="CAH37966">
        <property type="protein sequence ID" value="CAH37966"/>
        <property type="gene ID" value="BPSS0509"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0509"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4521"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFAWCSA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050188">
        <property type="term" value="F:phosphoenolpyruvate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012698">
        <property type="entry name" value="PEnolPyrv_PMutase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02320">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="289"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="544" mass="59084" checksum="99050DCBD6CCA67F" modified="2004-10-25" version="1">MLTSPSLEFLMEAHNGLSARIVREAGFKGIWASGLAISAQFGVRDNNEASWTQVVDVLEFMADASDLPILLDGDTGYGNFNNVRRLVRKLEQRGIAGVCIEDKQFPKTNSFIDGERQPLAEIDEFCGKIKAGKDSQSDPDFSIVARVEALIAGWGMDEALRRANAYAQAGADAILIHSKLSRPDEILQFAREWSGRAPLVIVPTKYYSTPTDVFRQAGISTVIWANHLIRASASAMQAVAREIQDSETLVNVEERVASVNEIFRLQDADEYSAAERIYLSSSARASSAALVLAASRGNGLEAVTEDKPKVMLPVAGKPLLRWLVDGFKKQGVNDITVVGGYRADAIDTSGVKLVVNERHAQTGELASLACAAERLTGDTIISYGDLLFRSYILRDLAESEAQFSVVVDSSQTQPSNQSVRDFAFCSAADDRGLFGQKAYLRRVSSDASEAAPHGRWIGLLNVRGAGVARLKAMLGTLQARDDFDALDLPALLNALVDAGEQIEVQYVHGHWRGVNDLDDFRRAGDFAHGQTPYAEQNAGSGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N35</accession>
    <name>Q63N35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110484.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0462"/>
    <dbReference type="EnsemblBacteria" id="CAH37918">
        <property type="protein sequence ID" value="CAH37918"/>
        <property type="gene ID" value="BPSS0462"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0462"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4465"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NLCIGEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="47"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="443" mass="47770" checksum="ECC88D12879C86A4" modified="2004-10-25" version="1">MPPDFHGPPMTDTFARRADALARRSYYEATVRRPADDPALAEALDVDVCVIGAGFAGLSTALDCRARGLSVAVLDARRPGWGASGRNGGQLIAGFAKDGEIERQLGVEGARAAWALSLDAIALVDERIARHGIDCDLARGYLSVATHPRRVPELRQWMEGATARWGHPSLEWLDARAVRARIASPRYVAGVHDPLSGHLHPLKYCLGLADAARREGARLFSHTPALEVVRGARPIVRTPAGEVRCRHVVACCNAGPGGVLPAATAARIAPVASYIVATEPLGADRANALIPRREAACDNNFFLDYFRLSADHRMLFGGRASSAGASPDALVDAMRKRMTGAFPQLADTRIEFAWGGFVDVTRNRAPDFGAIDPNYFYLQGFSGHGVALAGIAGRIVAQAIAGDSRAFDLFARLRHRRFPGGPAWRQPALALGMLYHRVRELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N71</accession>
    <name>Q63N71_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110448.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0424"/>
    <dbReference type="EnsemblBacteria" id="CAH37880">
        <property type="protein sequence ID" value="CAH37880"/>
        <property type="gene ID" value="BPSS0424"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0424"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4416"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFISSWV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="39320" checksum="E4C9E60E7E83F786" modified="2004-10-25" version="1">MTTGPAMLLTIAIPTYNRVSCLRLLVDSLLAQIAQAERRGDRVAILIADNASTDGTGEYLESLAASRFVTIHRHAHNRGAAANVVHCFRHAGSRYVWIIGDDDLPLPGAVDAVLRHLACAAPDLFLLAAKWVPENLEAAARACGKPGRAKRVDRIDLSLKASVMTTFISSWVVNREAYLHHYGDAGIDRFGDTLFPQLAWVFGLMRSGARFLSADGPWLLARAGNSGNYAVFDTFSHQYNRIVDQSFAEAGWLRDFHRQNILWNFIPGLVWSVRTERAGRFEPFDAAAVEKVLSSAYAGSRFYARIVLPMITRRAGVAKWYWVLARILRRARVCWIFACASTRRRLAMKSGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N73</accession>
    <name>Q63N73_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525443.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110446.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0422"/>
    <dbReference type="EnsemblBacteria" id="CAH37878">
        <property type="protein sequence ID" value="CAH37878"/>
        <property type="gene ID" value="BPSS0422"/>
    </dbReference>
    <dbReference type="GeneID" id="56531128"/>
    <dbReference type="KEGG" id="bps:BPSS0422"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6558"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IPHPYEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="586" mass="65016" checksum="B21A0BC8DEED3977" modified="2004-10-25" version="1">MNVYKKALVANFRFLKASRDVREAYLRAIPVADAGFLVPIGESRLDDADLLAKLTRWRNEHVHVYPTQFEATVDSTRAWLKERLLATDDRILFLVEDRHGRAVGHIGFNGCLNDERLFEIDNVVRGDAAGAKGLFSLALQALIEWARTTSNVEGFFLRVMDDNPRAIAFYARNGFAEERRIPLVGERRGETLSYREARDGEAAHKHFVRMAYRRTHEAGRSMILTAGPSISAREAVYAHDAAAHGWNRNWSKYLTSFEAAFADYVGVKHAIATSSCTGALQISLMALGIGAGDEVIVPDLTWVATANAVRYVGATPVFADIELDSWNLDARSLDALITPQTKAVIAVHMYGHPARMDAILEVAGRHGLKVIEDAAPAIGAEWRGRRCGSFGDFAAFSFQGAKLLVTGEGGMLATDDDALYEKALKIWDQGRNPSRTFWIDGDGVKFKMSNVQAAVGLGQLERADELIEMKRRIFDWYDEGLAGAPGIALNREIPDARSIYWMTSLRLDESAPIGRDDLMKALKARNVDTRPVFPAISRYPIWSRRQPPQPTASRVGQQAMNLPSGVCLSKDDVFYVCRQVRDLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N90</accession>
    <name>Q63N90_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110429.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0406"/>
    <dbReference type="EnsemblBacteria" id="CAH37861">
        <property type="protein sequence ID" value="CAH37861"/>
        <property type="gene ID" value="BPSS0406"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0406"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="67" mass="7507" checksum="48C88707BF6A69D0" modified="2004-10-25" version="1">MLQKEQWMQIHVLKAQGVSEGARDHAAPGHFSQHGGRGTCRPRKCRATNRVNRDQPGSERSRRTSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB9</accession>
    <name>Q63NB9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205394.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110400.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0380"/>
    <dbReference type="EnsemblBacteria" id="CAH37828">
        <property type="protein sequence ID" value="CAH37828"/>
        <property type="gene ID" value="BPSS0380"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0380"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4373"/>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RTYIGMI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="81" mass="9004" checksum="21F73CEC2B280C30" modified="2004-10-25" version="1">MARISGKLDKDGNLVSLGAAIRARRKELVMSQEALADFAEIDRSHMGKIERGERNVTFMNIVRIARALQLLPSELLRNAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NF2</accession>
    <name>Q63NF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531449.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110367.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0347"/>
    <dbReference type="EnsemblBacteria" id="CAH37795">
        <property type="protein sequence ID" value="CAH37795"/>
        <property type="gene ID" value="BPSS0347"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0347"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6467"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LGGTKWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017661">
        <property type="entry name" value="AminoethylPonate_ABC_PhnV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03255">
        <property type="entry name" value="PhnV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="29239" checksum="79D4556253D129B4" modified="2004-10-25" version="1">MSADFPARAAPVPRRELRWTDAASRVASRALVALAAAACCWLFVLPVVVVALSSVAGHWSGTILPAGYSLRWFERLGRPEFDALAASLEIGLGVAALGTALGVALALALEGRTRRGVGALVDALVMLPNGVPSVVLGLAVLIAYHAKPVDLSSSPAIVVFVQLALVLPFCYRCAAAALRPELAVLREAAASLGAPPAMVLRRVLLPQLVPAIRASLALGFALSLGELGATLTVYPPGFATVPIVVIGAVERGYYLPASALSLLLLGASLVALIAIAARAPRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NG0</accession>
    <name>Q63NG0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroshikimate dehydratase</fullName>
            <shortName evidence="1">DSD</shortName>
            <ecNumber evidence="1">4.2.1.118</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36241"/>
            <dbReference type="EC" id="4.2.1.118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial two-domain DSD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.118" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533828.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110359.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0339"/>
    <dbReference type="EnsemblBacteria" id="CAH37787">
        <property type="protein sequence ID" value="CAH37787"/>
        <property type="gene ID" value="BPSS0339"/>
    </dbReference>
    <dbReference type="GeneID" id="56531200"/>
    <dbReference type="KEGG" id="bps:BPSS0339"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6458"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPGQGEF"/>
    <dbReference type="UniPathway" id="UPA00088"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046565">
        <property type="term" value="F:3-dehydroshikimate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02238">
        <property type="entry name" value="DSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043700">
        <property type="entry name" value="DSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="350"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="497"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="684" mass="74632" checksum="73F5407D7F3062FF" modified="2004-10-25" version="1">MQRSIATVSLSGTLVEKLRAIRAAGFDGVEIFENDLLYFDGSPADVRAIAADLGLAIVLFQPFRDFEGVPPERLARNLERAKRKFELMHALGANRMLVCSNMSPDAIGDDALLIDQLGALARAAQAAGVVAAYEALAWGRNVKTYGHAWRLVDAVNHPSLGLALDSFHTLSLGDSPDGIARIPGERIAFVQIADAPKLAMDVLEWSRHYRSFPGQGDFDLAGFTARVIESGYAGPLSLEIFNDGFRAAPTALTAADGYRSLLYLEETTRERLACDARRARRAGGAPGAGETRGERERHDAHGERGEHRAHDKDDKPDDKRGGPDERESRAAHPRPAQPLFAPPPAPAHVGFQFIEFAVDAAAAENVAGWLGKLRFRRAGRHRSKDVTLYQHGAASIVLNAERDSFADAFFQEHGLSLCASAFRVDDARLAFERAAGYGYAPFSGRVGPNERVLPSVRAPDGSLNYFVDEAPGAPTLYESDFVLTDIDGPSEVGPLAGIDHVCLALPADALDTWVLFFKTAFGFEAERNWLVPDPYGLVRSRAVRSPDGSVRIALNASVDRHTAVVRSLERYRGTGLNHVAFRADDIVAAIAEFAADGVPFLRIPRNYYDDLAARYALPDETIDTLRRHHLLYDRDDAGGEFLHAYTELVDGRFSFEIVERRGGYDGYGAANAAVRLAAQAQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NM1</accession>
    <name>Q63NM1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110298.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63NM1"/>
    <dbReference type="STRING" id="272560.BPSS0278"/>
    <dbReference type="EnsemblBacteria" id="CAH37725">
        <property type="protein sequence ID" value="CAH37725"/>
        <property type="gene ID" value="BPSS0278"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0278"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4252"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NRHNTED"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanA_C" evidence="3">
        <location>
            <begin position="137"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="346" mass="39646" checksum="B3B36B2CC10A6A0F" modified="2004-10-25" version="1">MMLSVGNEDLDLTNRHNAEDWLPDRIRLRNVWLPLAHTFEIGERASRWYVHSEPCYLWRAAGRIHACPWHPGLPAAKRPTPRPRDADAACYPVVERFGYVWVWYGEPEAASDAFVPDVPFLPRDGGLPKYMQGNIRVDCCAPLLIENLLDLTHSDFLHAKVFGDQHADEDRVDVSYTSETVTMIRRCKNKSILPIMRWFGGVRAKYQDIHAVVHVHVRSSIALAYGRHTPGSDLPLFHPCVPESRNYCRLNFALNATQAPWPLRLLLPFVPYVVGLQDNSMVRRQSGRYLDAGERRDLYSRFDRAGLRYRILLQQLAKRQSEGDFSYADDALPSRDARGILGMPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NM7</accession>
    <name>Q63NM7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110292.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0272"/>
    <dbReference type="EnsemblBacteria" id="CAH37719">
        <property type="protein sequence ID" value="CAH37719"/>
        <property type="gene ID" value="BPSS0272"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0272"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4243"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAVICPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="438" mass="45949" checksum="97CC7BCECD8CA73F" modified="2004-10-25" version="1">MPADGAGVAPADAVSAAGLRTARGGAIAAAVIGNWLEFFDFTVYGFFAVIIGKLYFPSHDATTSLLLSVATFAAGFFTRPLGSIVLGVYADRRGRKAALNLTILLMALGTGMIALAPTYAQIGVLAPVIVVCARLMQGFSQGGEFGAATSTLVEHGGAARRGFRASWQLATQGGAALMGSGFAALLSNTLAKDALESWGWRVPFALGVLIAPVGMYLRRRLADDAPGAGHHGIDGGVLRELFARHGRTVLLLTLTVMGGTVSTYILTFYMPTYAIHTLGLPMKLSMFVGVASGCVMLVTCPLFGWLSDRIGSRRLPIFVGRGVLVVLLFPAFVLMNRYPSLAVVMPLTGLMLLFYSMGSASEFALMCESFPRRVRATGISIAYALAVTLFGGTAQLVATWLVRVTGSTLAPAAYVAVCVIVSLVAVGMLRETATETAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU7</accession>
    <name>Q63NU7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110222.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0202"/>
    <dbReference type="EnsemblBacteria" id="CAH37647">
        <property type="protein sequence ID" value="CAH37647"/>
        <property type="gene ID" value="BPSS0202"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0202"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4150"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RENIWQL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="74"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="297" mass="32431" checksum="E5BA6B270061F519" modified="2004-10-25" version="1">MAILEASSTKCGDSPGPSARRGIVNAGFVQDRINQAVWRSRGALRGYGRASGWTDPGEAAAIAWIAERVRDEPILDVGVGGGRTVPLLKTISADYTAVDYTPELVEICRRNHPGTRVHRMDARDMSAFADESFSLVVFSYNGIDAVDHDGRMAILKEFARVLRPGGFTLFSTHNLAGPSYREGPSRLARLPRRSANPFAIALDAARIAYSLPVGAFNYFRNSRFNRVFDGYAMRVCAAHKFGILVMYTDFATQQRQLADVGLKLRAAFGGSSGEPVRRDQDLGGEAWLHFVASKPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NZ3</accession>
    <name>Q63NZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531536.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110176.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0155"/>
    <dbReference type="EnsemblBacteria" id="CAH37600">
        <property type="protein sequence ID" value="CAH37600"/>
        <property type="gene ID" value="BPSS0155"/>
    </dbReference>
    <dbReference type="GeneID" id="56531394"/>
    <dbReference type="KEGG" id="bps:BPSS0155"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6210"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VQTYYMA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="310" mass="33163" checksum="FD1C4FB55676511C" modified="2004-10-25" version="1">MRLRHIEVFHAIMRTGSLSKAAQLLCVSQPAVSKVLAHAEQNLGIRLFSRAHGRLLPTREAELLFGETQKLQSNLERIRALSRNLALQPEGQLRVGCLPSLGLSLIPQAVKAFRDDYPRVALKIQTLHTDALLNALLTRDLDVAVAIDPPARPGITSAELGRTAVVSVGPPDDDAPDAPLSLHAFMEGESIGIGTEDPLGDAIGNALEAFGEDRVTMVEAHTWYVARALAARGVGRVLLDELTARAPGEPVTIRPIEPALSVGVFALWRDGGLDSHAGATFVDALRAPFGEPSGKPPSMRAPGAPKRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P81</accession>
    <name>Q63P81_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transport transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dctD</name>
        <name evidence="9" type="ordered locus">BPSS0063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529601.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110088.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0063"/>
    <dbReference type="EnsemblBacteria" id="CAH37507">
        <property type="protein sequence ID" value="CAH37507"/>
        <property type="gene ID" value="BPSS0063"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0063"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6073"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QLLSHDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="150"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="448" mass="49055" checksum="E4D672F54A4AA72E" modified="2004-10-25" version="1">MMNADNAYGREAVYVIEDDAAVRLGCSQALALEGIGVREFEDAESALAALKRDPPAAIVSDVRLPGMGGLALLDSMKAHPRDADIPVILMTGHGDVAMAVGAMRCGAYDFIEKPFHSDRLVDTVRRALEHRKLVIENRSLRAQLSGERPLLGSAPAMQRVHALIDAIGPTSADVLIIGETGTGKEVLARALHAASRRTGPFVALNCAALPEAVFESEIFGHEPGAFTGAQQRRIGKFEYASGGTLFLDELESMPLSLQAKLLRALQERSIERLGSNVSVAVDVRVIAAVKQDLKQLAADGLFRSDLYFRLNVASIELPPLRRRTDDIPELFSHFLRAAAVRFEKPEPVWTQEDMMRWQLYDWPGNVRELKNTAERFCLGLEDGLPRSPAGFDSLASRMVSAERAYIEEALRNAGGQVAKAAELLGLPRKTLYDKITRHGIDMTAFRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PI9</accession>
    <name>Q63PI9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative periplasmic amino acid binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL3388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524498.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109980.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3388"/>
    <dbReference type="EnsemblBacteria" id="CAH37399">
        <property type="protein sequence ID" value="CAH37399"/>
        <property type="gene ID" value="BPSL3388"/>
    </dbReference>
    <dbReference type="GeneID" id="56527766"/>
    <dbReference type="KEGG" id="bps:BPSL3388"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1806"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PEYTKQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266653" evidence="3">
        <location>
            <begin position="26"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="28"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH37399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="379" mass="40028" checksum="2A8C5A5CDF8B625A" modified="2004-10-25" version="1">MQHTMKKLAGATFVAVMSLAGTAHADDVKIGFAAPMTGAQAHYGKDMQNGIVLAIEDINATKPTIGGKPVKFVLDTQDDQADPRTGTTVAQKLVDDGIKGMLGHFNSGTTIPASRIYANAGIPQIAMATAPEYTTQGYKTTFRMMTSDTQQGSVAGTFAVKDLGMKKIAIVDDRTAYGQGLADQFEKAAKAAGATIVDREFTNDKAVDFKAILTKLKATKPDLVYYGGADSQAAPMAKQMKSLGVTAPLMGGEMVHTPTFLKIAGDAAEGSIASLAGLPLAEMPGGKAYADKYKKRFGEDVQTYSPYAYDGAMAMFSAMKKANSTDPAKYLPLLAKTDMAGVTSTHIAYDAKGDLRNGGITMYKVEKGEWKPLKSIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PM5</accession>
    <name>Q63PM5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938961.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109944.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3348"/>
    <dbReference type="EnsemblBacteria" id="CAH37361">
        <property type="protein sequence ID" value="CAH37361"/>
        <property type="gene ID" value="BPSL3348"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3348"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1856"/>
    <dbReference type="eggNOG" id="COG4128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPREVFK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008900">
        <property type="entry name" value="Zot_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05707">
        <property type="entry name" value="Zot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="301" mass="33518" checksum="B6803107C5E6B8C7" modified="2004-10-25" version="1">MITLITGVPGSGKTLHAVWLLTKIAKGRRVLVDGIRDLAIEHVEIDEPWLRQWHEKAEAQDLIVIDEAQRIYPPTTVSQKPTPDVEQLHVHRHKGVDFILITQHPQRISKTVRDLVGRHIHVRNLFGLKRAMLYEWDHCHNPSSLKDAVKRQWPYPREVFKLYTSAEVHTKKQAVVPKALFLLPIGIVVFVVLAVKIYHKARDGFGAEPVRHVESAAAASNAVVARPIDTVKSSEWRVAGRYSVDGVGYVALVAMDGRLRAVPVRGFSGQGARLTGEVDGKTVAGWTGVQTVKTEQYGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PN0</accession>
    <name>Q63PN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL3343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109939.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3343"/>
    <dbReference type="EnsemblBacteria" id="CAH37356">
        <property type="protein sequence ID" value="CAH37356"/>
        <property type="gene ID" value="BPSL3343"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3343"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3803"/>
    <dbReference type="eggNOG" id="COG4679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PHSKAMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="119" mass="13922" checksum="8F0D0E67B7B9BC0E" modified="2004-10-25" version="1">MQKHSKFANMKFDWTVVYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGRQVVVLHSFVKKTQETPQHELRIAQARLREVRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PZ2</accession>
    <name>Q63PZ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetic acid degradation protein PaaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">paaC</name>
        <name evidence="1" type="ordered locus">BPSL3232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538977.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109826.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3232"/>
    <dbReference type="EnsemblBacteria" id="CAH37243">
        <property type="protein sequence ID" value="CAH37243"/>
        <property type="gene ID" value="BPSL3232"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3232"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2005"/>
    <dbReference type="eggNOG" id="COG3396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NGDFAHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011882">
        <property type="entry name" value="PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037834">
        <property type="entry name" value="PA_CoA_Oase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02158">
        <property type="entry name" value="PA_CoA_Oxy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="267" mass="29493" checksum="AD6D69050DF4C89F" modified="2004-10-25" version="1">MTTTPQHLAYVLRLADNALILGQRNAEWCGHGPVLEEDIALTNMSLDLIGQARLLYTHAAELERQLTGAARTEDDYAYFRAEREFANYTFVELPHYGPLCGTAHAELDYAVTVVRNFLYSTLMLHLWTALEASGDAQLAAIAAKSVKETRYHEHYAREWLIRFGDGTDESHRRAQAALDHLMPYTREFFATDAIDDAAAAAGIGPAIASIEPAWRADIEAALAEATLALPTAGQYVPTGKRGEHSEHMGYLLAELQSVARQHPGATW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q13</accession>
    <name>RL23_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">BPSL3211</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199275.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109805.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q13"/>
    <dbReference type="SMR" id="Q63Q13"/>
    <dbReference type="STRING" id="272560.BPSL3211"/>
    <dbReference type="EnsemblBacteria" id="CAH37222">
        <property type="protein sequence ID" value="CAH37222"/>
        <property type="gene ID" value="BPSL3211"/>
    </dbReference>
    <dbReference type="GeneID" id="60548049"/>
    <dbReference type="GeneID" id="62009747"/>
    <dbReference type="GeneID" id="64462497"/>
    <dbReference type="GeneID" id="66545622"/>
    <dbReference type="KEGG" id="bps:BPSL3211"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2027"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="PRO" id="PR:Q63Q13"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000272722" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="104" mass="11740" checksum="4F2F7751C19CAC14" modified="2004-10-25" version="1">MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q14</accession>
    <name>RL2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">BPSL3210</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199274.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109804.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q14"/>
    <dbReference type="SMR" id="Q63Q14"/>
    <dbReference type="STRING" id="272560.BPSL3210"/>
    <dbReference type="EnsemblBacteria" id="CAH37221">
        <property type="protein sequence ID" value="CAH37221"/>
        <property type="gene ID" value="BPSL3210"/>
    </dbReference>
    <dbReference type="GeneID" id="56527948"/>
    <dbReference type="KEGG" id="bps:BPSL3210"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2028"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000237165" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="275" mass="30258" checksum="3518E7D2F352C979" modified="2004-10-25" version="1">MAIVKVKPTSPGRRAMVKVVNKDLHKGKPHAALLDTQSSKAGRNNNGRITTRHQGGGHKQHYRVIDFRRTKDGIPAKVERLEYDPNRSANIALVLYADGERRYIIAPKGVTVGQQLMSGSEAPIRAGNTLPIRNIPVGTTIHCIEMLPGKGAQMARSAGTSAMLLAREGLYAQVRLRSGEIRRVHIECRATIGEVGNEEHSLRQIGKAGANRWRGIRPTVRGVAMNPIDHPHGGGEGRTAAGRDPVSPWGTPTKGFRTRRNKRTTTMIVQRRHKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q23</accession>
    <name>RL5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">BPSL3201</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202757.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109795.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q23"/>
    <dbReference type="SMR" id="Q63Q23"/>
    <dbReference type="STRING" id="272560.BPSL3201"/>
    <dbReference type="EnsemblBacteria" id="CAH37212">
        <property type="protein sequence ID" value="CAH37212"/>
        <property type="gene ID" value="BPSL3201"/>
    </dbReference>
    <dbReference type="GeneID" id="60548059"/>
    <dbReference type="KEGG" id="bps:BPSL3201"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2037"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000242979" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="179" mass="20027" checksum="8A14BB11FD971460" modified="2004-10-25" version="1">MARFQEFYKEKVVPGLIEKFGYKSVMEVPRITKITLNMGLGEAVADKKIIENAVGDLTKIAGQKPVVTKARKAIAGFKIRQGYPIGAMVTLRGRAMYEFLDRFVTVALPRVRDFRGVSGRAFDGRGNYNIGVKEQIIFPEIDYDKIDALRGLNISITTTAKTDDEAKALLASFKFPFRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q32</accession>
    <name>IF12_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA2</name>
        <name type="ordered locus">BPSL3192</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004521905.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109786.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63Q32"/>
    <dbReference type="SMR" id="Q63Q32"/>
    <dbReference type="STRING" id="272560.BPSL3192"/>
    <dbReference type="EnsemblBacteria" id="CAH37203">
        <property type="protein sequence ID" value="CAH37203"/>
        <property type="gene ID" value="BPSL3192"/>
    </dbReference>
    <dbReference type="GeneID" id="60548068"/>
    <dbReference type="GeneID" id="62009766"/>
    <dbReference type="GeneID" id="64462478"/>
    <dbReference type="GeneID" id="67433089"/>
    <dbReference type="KEGG" id="bps:BPSL3192"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2046"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ECLRSAM"/>
    <dbReference type="PRO" id="PR:Q63Q32"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000095762" description="Translation initiation factor IF-1 2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="72" mass="8218" checksum="983A496214B869D9" modified="2004-10-25" version="1">MAKDDVIQMQGEVIENLPNATFRVKLENGHVVLGHISGKMRMHYIRILPGDKVTVELTPYDLSRARIVFRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q43</accession>
    <name>Q63Q43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL3181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="4">Binds 2 heme c groups covalently per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004557316.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109775.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3181"/>
    <dbReference type="EnsemblBacteria" id="CAH37192">
        <property type="protein sequence ID" value="CAH37192"/>
        <property type="gene ID" value="BPSL3181"/>
    </dbReference>
    <dbReference type="GeneID" id="56594575"/>
    <dbReference type="KEGG" id="bps:BPSL3181"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2057"/>
    <dbReference type="eggNOG" id="COG2863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGCHSPN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024167">
        <property type="entry name" value="Cytochrome_c4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000005">
        <property type="entry name" value="Cytochrome_c4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266525" evidence="7">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="128"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000005-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000005-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="215" mass="22406" checksum="D7B65A43A3AA51E7" modified="2004-10-25" version="1">MNRLSKSLVVLQFAVAGLAGFMAEARAADAAKPDLDRGKAIATQVCAACHGVDGNSATGSFPKLAGQHPDYLVKQLHDFKTQPGAKGPVRVNSVMVGFASALNDQDARNVAAYYGSQSAKPGAARNAATVPVGQKIYRGGIAEKGVPACASCHGPTGQGIPVQYPRLSGQWADYTVAQLTAFQQGTRSNDAMHQIALRLTDSEVKAVADYIAGLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QE9</accession>
    <name>PRMC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="1">RF MTase</shortName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmC</name>
        <name type="synonym">hemK</name>
        <name type="ordered locus">BPSL3074</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527812.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109669.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QE9"/>
    <dbReference type="SMR" id="Q63QE9"/>
    <dbReference type="STRING" id="272560.BPSL3074"/>
    <dbReference type="EnsemblBacteria" id="CAH37085">
        <property type="protein sequence ID" value="CAH37085"/>
        <property type="gene ID" value="BPSL3074"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3074"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2180"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000414506" description="Release factor glutamine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <sequence length="285" mass="30250" checksum="0F3239D23E5AC886" modified="2004-10-25" version="1">MNTTKPSPATAAELLRASPLDALDARILLAHALGWSRTQLITRADEPLDAAARARYLALQARRAAGEPIAQLTGAREFFGLEFDITPDVLIPRPETELLVETALDAIDGIASPCVLDLGTGSGAIAVSIASERPDARVWALERSVAALDVARRNARKLLDPARAGGPLRFLESDWYAALDPGLRFHVVVSNPPYIARHDPHLAEGDLRFEPRGALTDENDGLAAIRTIVAGAHAFVAPGGALWLEHGYDQAAAVRTLLDAAGFADVESRADLASIERASGGRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QJ6</accession>
    <name>Q63QJ6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable peptidoglycan glycosyltransferase FtsW</fullName>
            <shortName evidence="7">PGT</shortName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerase</fullName>
            <shortName evidence="7">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ftsW</name>
        <name evidence="8" type="ordered locus">BPSL3026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Peptidoglycan polymerase that is essential for cell division.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SEDS family. FtsW subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194175.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109622.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3026"/>
    <dbReference type="EnsemblBacteria" id="CAH37038">
        <property type="protein sequence ID" value="CAH37038"/>
        <property type="gene ID" value="BPSL3026"/>
    </dbReference>
    <dbReference type="GeneID" id="56528168"/>
    <dbReference type="KEGG" id="bps:BPSL3026"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2240"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00913">
        <property type="entry name" value="PGT_FtsW_proteobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="430" mass="46417" checksum="25A8D950E86B9641" modified="2004-10-25" version="1">MSWSDRLVSRFNGVRDAGGAAAPRTAARAASGARATAGGLASVVNGARPTRSRMLDFDYSLLWVSIALLGLGVVMVYSASIAMPDSPKYASYHDYAFLLRHCVSLVVAFVAAVIAFRVPVSTWDKYAPHLFLIALVGLVIVLIPHVGKGVNGARRWIPLGITNMQPSEIMKLAVTIYAANYTVRKQEYMQSFAKGFLPMACAVGLVGALLLLEPDMGAFMVIAAIAMGVLFLGGVNGKLFGGLVATAVGTFTMLVWLSPWRRERIFAYLDPWDERYAQGKAYQLTHSLIAFGRGEWFGVGLGGSVEKLNYLPEAHTDFILAVIGEELGFVGVLVVILLFYWIVRRAFEIGRQALALDRTFAGLMAKGVGIWFGAQAFINMGVNLGLLPTKGLTLPLVSYGGSGILLNCVALAVLLRVDYENRVLMRGGKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-24" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QL1</accession>
    <name>ZAPD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein ZapD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Z ring-associated protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zapD</name>
        <name type="ordered locus">BPSL3012</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to mid-cell in an FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZapD family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195118.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109607.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QL1"/>
    <dbReference type="SMR" id="Q63QL1"/>
    <dbReference type="STRING" id="272560.BPSL3012"/>
    <dbReference type="EnsemblBacteria" id="CAH37023">
        <property type="protein sequence ID" value="CAH37023"/>
        <property type="gene ID" value="BPSL3012"/>
    </dbReference>
    <dbReference type="GeneID" id="56528183"/>
    <dbReference type="KEGG" id="bps:BPSL3012"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2257"/>
    <dbReference type="eggNOG" id="COG4582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LPAYYAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01092">
        <property type="entry name" value="ZapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009777">
        <property type="entry name" value="ZapD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027462">
        <property type="entry name" value="ZapD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036268">
        <property type="entry name" value="ZapD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39455">
        <property type="entry name" value="PTHR39455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07072">
        <property type="entry name" value="ZapD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160950">
        <property type="entry name" value="SSF160950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000211664" description="Cell division protein ZapD">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01092"/>
        </source>
    </evidence>
    <sequence length="251" mass="28878" checksum="94EE862DA2AF925C" modified="2004-10-25" version="1">MILYEYPFNERIRTLLRLEDLFERFTFFVAQEDAREHHVALTTLFEISEVAGRADLKSDLMKELERQRQTLAPFRGNPGIEQNALEAVLGEIEQTLANLAQMQGKTGQHLIDNEWLASIRSRAVIPGGTCKFDLPSYYAWQQWPAEQRRHDIAKWAMPLLPLRDAAMIVLRLARESGQASKVMAMQGSYQQMLSGRTYQLMQVRVPPELRVIPEASANKYMLWVRFTAQDGDVRPRAVDIDVPFQLTLCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QL5</accession>
    <name>Q63QL5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative type IV pilus assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL3008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109603.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3008"/>
    <dbReference type="EnsemblBacteria" id="CAH37019">
        <property type="protein sequence ID" value="CAH37019"/>
        <property type="gene ID" value="BPSL3008"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3008"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3437"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NMGVPAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="419" mass="44254" checksum="541CFB652E657551" modified="2004-10-25" version="1">MSATPSNPSFPAVRSAASALPRPRAPELADDAPAVGIVADMLRAAHERDASDIHVEPCESGWRVRLRIDGVLHEFARPPAHLRDACVTRIKVLARMDIAERRVPQDGRLRLPLAPGRAGDYRVSSLPTLHGEKLVLRRLETLPADLSLAALGFDAAQARGVEAAIGAPHGLILVTGPTGSGKTLSLYCFLQMLNDVSRNVCTVEDPAEIELDGINQVGVREKAGLTFAVALRAFLRQDPDVIMVGEIRDAQTADVALKAAQTGHLVLSTLHTNDAPAAVARLLDIGVAPYNLAAALRLVTAQRLVRRLCPACRAPSDASPATLRAAGFDAASIDAGWRPYAANGCAACHGIGYRGRIGIHQVMPLSAELRNLTVARAGSAELARQARAEGMASLRDAALARVRDGTTSLSEALATTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QY9</accession>
    <name>Q63QY9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pntB</name>
        <name evidence="18" type="ordered locus">BPSL2885</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522105.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109479.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2885"/>
    <dbReference type="EnsemblBacteria" id="CAH36895">
        <property type="protein sequence ID" value="CAH36895"/>
        <property type="gene ID" value="BPSL2885"/>
    </dbReference>
    <dbReference type="GeneID" id="56528313"/>
    <dbReference type="KEGG" id="bps:BPSL2885"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2406"/>
    <dbReference type="eggNOG" id="COG1282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KRGMSAG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="7"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAH36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="484" mass="50674" checksum="EC8583F1CAC0CD9A" modified="2004-10-25" version="1">MSMNVVTLLYLVASVCFIQALKGLSNPKSARRGNLFGMVGMAIAILTTVALIAKQAAWLGANLPLGLALVFGALVIGGAVGAVIAARVEMTKMPELVAAMHSLIGLAAVCIAIAVVAEPEAFGLVPQDASAPNFIPYGNRIELFIGTFVGAITFSGSVIAFGKLSGKYRFRLFQGAPVVYPGQHLINLMLALAMLGFGILFFITQSWLPFGIMTAIAFALGVLIIIPIGGADMPVVVSMLNSYSGWAAAGIGFSLNNAMLIIAGSLVGSSGAILSYIMCHAMNRSFFNVILGGFGGDAAAATAGGAKEQRPVKSGSAEDASFMLGNAETVVIVPGYGLAVARAQHALKELTDKLVEKGIDVKYAIHPVAGRMPGHMNVLLAEAEVPYEIVHEMEDINGEFGQVDVVLVLGANDVVNPAAKNDPKSPIAGMPIIEAYKARTVIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKVIEDMVKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R54</accession>
    <name>Q63R54_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_DnaA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196484.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109414.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2819"/>
    <dbReference type="EnsemblBacteria" id="CAH36829">
        <property type="protein sequence ID" value="CAH36829"/>
        <property type="gene ID" value="BPSL2819"/>
    </dbReference>
    <dbReference type="GeneID" id="56594692"/>
    <dbReference type="KEGG" id="bps:BPSL2819"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2485"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWGQIYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032297">
        <property type="term" value="P:negative regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017788">
        <property type="entry name" value="Hda"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03420">
        <property type="entry name" value="DnaA_homol_Hda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_DnaA" evidence="1">
        <location>
            <begin position="97"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="241" mass="26370" checksum="907A8DC775DB2AEA" modified="2004-10-25" version="1">MTVTRQLTLDLGTPPPSTFDNFYSGTNAELVTRLRELDLALAAGPVADRTFYVWGEAGSGRSHLLQALVHDTTYGHARYVSPQGGLDALAFDPRVSLYAVDDCDALNDAQQIALFNLFNEVRAHPMTALVVAGPAAPLALDVREDLRTRLGWGLVFHLAPLTDEGKAAVLKHAAKERGIALADDVPSYLLTHFRRDMPSLMSLLDALDRFSLEQKRAVTLPLLRAMLAAPEREEPAPGRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RM4</accession>
    <name>Q63RM4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcm</name>
        <name evidence="10" type="ordered locus">BPSL2648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522277.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109244.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2648"/>
    <dbReference type="EnsemblBacteria" id="CAH36656">
        <property type="protein sequence ID" value="CAH36656"/>
        <property type="gene ID" value="BPSL2648"/>
    </dbReference>
    <dbReference type="GeneID" id="56528549"/>
    <dbReference type="KEGG" id="bps:BPSL2648"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2698"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVDTQVR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="9">
        <location>
            <begin position="65"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH36656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="217" mass="24029" checksum="65614EA9EDED3EBD" modified="2004-10-25" version="1">MNIEKARFNMIEQQIRPWDVLDQDVLSLLSVVKRENFVPAAYRDLAFADVELPLPSGQKMLFPRVEARILQELAVKKHENVLEIGAGGGYMAALLAARGQRVTTVEIDPDLAKFAEENLKKNGVTNAEVVLGDGSRGWPAKAPYDVICVSGGLPVVPQELLEQLKVGGRLAAFVGGRPVMKAQIITRIDDTQYRVADVFETYVDHLVNAIEPSRFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RP9</accession>
    <name>Q63RP9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185675.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109218.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2622"/>
    <dbReference type="EnsemblBacteria" id="CAH36630">
        <property type="protein sequence ID" value="CAH36630"/>
        <property type="gene ID" value="BPSL2622"/>
    </dbReference>
    <dbReference type="GeneID" id="56594854"/>
    <dbReference type="KEGG" id="bps:BPSL2622"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2731"/>
    <dbReference type="eggNOG" id="COG3183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VVIPREM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="152" mass="17103" checksum="6E5A363C18A03EC5" modified="2004-10-25" version="1">MTAFLLIWSPKKWPWPELPEMAARVKAGEAVADVWGCGFSRSILPGDRVFLHRVAQEPKGVFGSGYVTRGPYEVPDPQTKRGYRLCIDFVYDWLVDGHSEVVIPRDALRVHPFSVQTWDAQTSGTSIKPVAEGALEKRWAELTGKRKPPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RT2</accession>
    <name>Q63RT2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522317.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109185.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2589"/>
    <dbReference type="EnsemblBacteria" id="CAH36597">
        <property type="protein sequence ID" value="CAH36597"/>
        <property type="gene ID" value="BPSL2589"/>
    </dbReference>
    <dbReference type="GeneID" id="56528611"/>
    <dbReference type="KEGG" id="bps:BPSL2589"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2770"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EDWLFND"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266738" evidence="4">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="164" mass="17559" checksum="3B360F257DE73ABB" modified="2004-10-25" version="1">MTTRSELFRFRAAWRGAALCACAAVLAACTITLPPPHGAVVVPGVSSMSATEYRAAIAQRIADSNSDRILHGTPQAMLRSLVVVAFTVDRNGQLVKSAVYRSNGDDEAEGIALASLRRAAPLPPPPAKMLDGRGQLELMESWLFNDNGQFQLRTKAAPQAQTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU1</accession>
    <name>Q63RU1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109176.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2579"/>
    <dbReference type="EnsemblBacteria" id="CAH36587">
        <property type="protein sequence ID" value="CAH36587"/>
        <property type="gene ID" value="BPSL2579"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2579"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2784"/>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="352" mass="38938" checksum="B77351652918AEF1" modified="2004-10-25" version="1">MIVRGPRPTERFYLLRREIAEDRRLSWAARGMLVHLLVKPDSWRVSVQALVNETADAGLSSGRDAVYRILRELQDAGYLSRGQTKSDDGSFEAMDYIVSEIPNAPLTENPEAAPRTGLPLTGLPCTADPTQAKNQYKQGLRKAPKGADAPPVDLLGNEIVESVSDLACPVDEIVAAYHELMPDNPRVKAVHGDRRKAIAARWREASKLDCKPFGYSTVDDGLRAWRKFFAVCARSAFLTGKATPKPGCKRFRADIDFLTSPSGFTKCLEGKYQQDVEEQQDGSWSASREGIEAKAAELGIVPKVGESYSSLRDRCEAELRRPCQARPSRTSTGGGYEHVRHEFDATQREKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD0</accession>
    <name>Q63SD0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisQ</name>
        <name evidence="7" type="ordered locus">BPSL2394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527442.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108986.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2394"/>
    <dbReference type="EnsemblBacteria" id="CAH36396">
        <property type="protein sequence ID" value="CAH36396"/>
        <property type="gene ID" value="BPSL2394"/>
    </dbReference>
    <dbReference type="GeneID" id="56528793"/>
    <dbReference type="KEGG" id="bps:BPSL2394"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3007"/>
    <dbReference type="eggNOG" id="COG4215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IWTFVWI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030199">
        <property type="entry name" value="HisQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30133:SF1">
        <property type="entry name" value="PTHR30133:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="25139" checksum="0C6CD65467D99124" modified="2004-10-25" version="1">MFLYGFGPLIWAGTVQTIELSVLSLAAAVLLGLVGAVAKLSHNRVLRAIATGYTTLIRSVPDLVLMLLLFYSIQIWLNQFTDLMSWDQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGSAYGMNGMRVFARIMFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTASNLVLRQLEKRYSIGVRHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63ST7</accession>
    <name>Q63ST7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL2234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108829.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2234"/>
    <dbReference type="EnsemblBacteria" id="CAH36236">
        <property type="protein sequence ID" value="CAH36236"/>
        <property type="gene ID" value="BPSL2234"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2234"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2537"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SVIKLDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="426" mass="45077" checksum="10F4E973EF92FB69" modified="2004-10-25" version="1">MPAAFIGTSTRMSMPFVTRRKLVAFALLSLGAITLAAWLVKPSADARAAAAKQADAAIPVTAAIVGTMNLPVYLTGVGAVTPQYDVTVRSQVDGQITHVRFREGQQVRAGDVLVEIDRRALQAAADQATAKLEQDKATLANARLELARHQRLAEMNAAPVQMLDTWKARVNELHAQIRGDQAAVQNARVAVDYTTIRAPISGRIGFRLVDQGNLVKANDTALLTLVTTSPITAIYSESQDALPAIQAALRRGEVEAVAMSTDGETTLSHGRLRTIENRVDPTSGVVRMKAVFENADGALWPGQSVMIRTVVDVLRNATAVPEDAIQIGPDGSFVYVIGAGDKVAMRPVEVSHRVLGYAAVKHGLQAGERVVVQGQYRLQDGARVAATMMPAHDAPAAAAAAGARNARAPAAGREAPAVSATNARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TB3</accession>
    <name>Q63TB3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108653.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36055">
        <property type="protein sequence ID" value="CAH36055"/>
        <property type="gene ID" value="BPSL2054"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2054"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="17955" checksum="ECE97B843A83384C" modified="2004-10-25" version="1">MRRETRAQRVLPGDDLSDRFVLRALEPRGCAVGVVARLHQHGRAQADVVPRNRHADEHAAAVAAAVQVHGRRLLADGRDRVDCRAPGVVRRRRGHEYLRHELRFRRLDLRRARLRGRVRARHVGAARGRDRLCVSSIRTRGHLADPCVRAANPTWHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TF4</accession>
    <name>Q63TF4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193860.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108612.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2014"/>
    <dbReference type="EnsemblBacteria" id="CAH36013">
        <property type="protein sequence ID" value="CAH36013"/>
        <property type="gene ID" value="BPSL2014"/>
    </dbReference>
    <dbReference type="GeneID" id="56595380"/>
    <dbReference type="KEGG" id="bps:BPSL2014"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4171"/>
    <dbReference type="eggNOG" id="COG4520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NLRPQFC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032635">
        <property type="entry name" value="Anti_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16998">
        <property type="entry name" value="17kDa_Anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267125" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="17kDa_Anti_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="13879" checksum="FA2EAEDDC8674809" modified="2004-10-25" version="1">MTTRARVSILPRVLVGAACAAAALGAHAQNNLNFLNDTPISYFSKADTASLAKAVQKVRDEGKDGETVDWVNDGRGTKLAAKLTPSTTEQEGRTCREIKTEIEAKGQSMTLRPLYCKTAAGKWQLQKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-24" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TM7</accession>
    <name>SYFB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheT</name>
        <name type="ordered locus">BPSL1940</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193113.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108539.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63TM7"/>
    <dbReference type="SMR" id="Q63TM7"/>
    <dbReference type="STRING" id="272560.BPSL1940"/>
    <dbReference type="EnsemblBacteria" id="CAH35939">
        <property type="protein sequence ID" value="CAH35939"/>
        <property type="gene ID" value="BPSL1940"/>
    </dbReference>
    <dbReference type="GeneID" id="56595482"/>
    <dbReference type="KEGG" id="bps:BPSL1940"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4084"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126860" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="405"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="707"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <sequence length="810" mass="88620" checksum="07BAF82EC8678908" modified="2004-10-25" version="1">MQFPESWLRTFVDPQLTTDELSHALTMAGLEVESLRPAAPPTEKIVVGRVLEVVKHPDADKLNVCQVDAGTGATLQIVCGAPNVAPGIKVPVALVGAKLPPAEEGGAPFAIKLSKLRGVESQGMLCSARELKLSEDHSGLMILPEGTPVGQDIREALNLDDTVFEIKLTPNKADCLSVFGIARETAAITGAPLAAPDIRPVLAELTETLPVKISAPDLCGRFSGRVIRGVNARAKTPHWMVERLERAGQRSVSALVDISNYVMFELGRPSHVFDLDKIHGGIDVRWGKRGESLKLLNGNTIELDETVGVISDGAQVESLAGIMGGDSTAVTLDTTNIYLEAAFWWPDSIRGRARKYNFSTDAAHRFERGVDYSTTVEHVERITQLILDICGGQAGPVDDQIVSLPQRAPVSMRASRANRIIGVEIGEDEIAQIFTRLGLAFERDGDVFRVTPPPHRFDIEIEEDLIEEVARIYGFEKIPARPPVAKSEMRATDETRRSVHAIRHALAARDYAETVNFSFVDAEWERDFAGNDNPVRLLNPIASQLSVMRTTLFGSLVGVLRHNLNRRAERVRVFEAGRVFVADPSVKAGELAVEGYAQPKRIGALAYGPVVEEQWGTATRQVDYFDVKGDLEALLAPVPARFVKAEHPALHPGRSARIEVDGHAVGWIGELHPRLMQKYELPHAPVMFEIDTDALVARALPAPSEVSKFPPVRRDIAVVVDQKVEVQALFDEMKKALADDACKFVQRVALFDEFRAKSNTSGGLSAHEKSLAFRVTLQDAAGTLQDETVDQAIQTLVDRMARVYGARLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TT5</accession>
    <name>Q63TT5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538336.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108481.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1882"/>
    <dbReference type="EnsemblBacteria" id="CAH35881">
        <property type="protein sequence ID" value="CAH35881"/>
        <property type="gene ID" value="BPSL1882"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1882"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4022"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TSMRQIT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041586">
        <property type="entry name" value="PsrA_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17939">
        <property type="entry name" value="TetR_C_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="318" mass="33238" checksum="5ABEA0C0E6A5F467" modified="2004-10-25" version="1">MAVRQASRQSGGTKARILDAAEDLFIEHGFEAMSMRQITSRAAVNLAAVNYHFGSKEALIHAMLSRRLDQLNEERLRILDRFDVQLGAHVTCEHVLGAMFIPALQASRDPQRGGRAFLRLIGRAYTDPSAFVRNFLTAHYASVAGRFFDAFQRALPNLPRAELGWRLHYAIGALSGALAGAETESLIDEFTQGRTMNDVQMIARLSALIVAALKAPMPDATQLTIFASVLDGAAASASATQPAEPVALALAPAAIVPAAACALTPAAPAPMPAPSAVPPASVASASTAPAAAATPSAPCTDAFAAEPIGAIAHETHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TU4</accession>
    <name>Q63TU4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">23S rRNA (guanosine-2'-O-)-methyltransferase RlmB</fullName>
            <ecNumber evidence="6">2.1.1.185</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">23S rRNA (guanosine2251 2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">23S rRNA Gm2251 2'-O-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rlmB</name>
        <name evidence="8" type="ordered locus">BPSL1873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the ribose of guanosine 2251 in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10239"/>
            <dbReference type="Rhea" id="RHEA-COMP:10241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.185"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.185" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191786.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108472.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1873"/>
    <dbReference type="EnsemblBacteria" id="CAH35872">
        <property type="protein sequence ID" value="CAH35872"/>
        <property type="gene ID" value="BPSL1873"/>
    </dbReference>
    <dbReference type="GeneID" id="56595667"/>
    <dbReference type="KEGG" id="bps:BPSL1873"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4009"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070039">
        <property type="term" value="F:rRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01887">
        <property type="entry name" value="23SrRNA_methyltr_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024915">
        <property type="entry name" value="23S_rRNA_MeTrfase_RlmB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="7">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="247" mass="26289" checksum="1AA3FCC776FD364D" modified="2004-10-25" version="1">MSRLKVLYGFHAVTARMRHDASTVAEVFYDATRRDRRMQDFLQAAKEAGVRLIAADETRLWGLAHTERHQGVVARVEDLPLAQNLAELLDGIAGPALLLVLDGVTDPHNLGACLRVADAAGAHAIIAPRDRAAGLNATAAKVASGAADTVPYITVTNLARALRELKDAGVWVIGTSDDATASVYDTKLDGPVALVMGAEGEGMRRLTRDTCDEVMFIPMAGSVESLNVSVASGVCLYEAVRQRGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63U30</accession>
    <name>Q63U30_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192056.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108386.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1786"/>
    <dbReference type="EnsemblBacteria" id="CAH35785">
        <property type="protein sequence ID" value="CAH35785"/>
        <property type="gene ID" value="BPSL1786"/>
    </dbReference>
    <dbReference type="GeneID" id="56595573"/>
    <dbReference type="KEGG" id="bps:BPSL1786"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3894"/>
    <dbReference type="eggNOG" id="COG3251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QYSIWPH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="80" mass="8776" checksum="8B1CD91AB1C00E42" modified="2004-10-25" version="1">MTQAQQPASAPADADDVVYAVVVNDEEQYSIWPTFRAVPAGWREAGVRGPKAECLAHIEAVWTDMRPASLRRHLDAARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UD9</accession>
    <name>Q63UD9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108277.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1666"/>
    <dbReference type="EnsemblBacteria" id="CAH35664">
        <property type="protein sequence ID" value="CAH35664"/>
        <property type="gene ID" value="BPSL1666"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1666"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1879"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LANCMLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="3">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1454" mass="161703" checksum="D45827855417B167" modified="2004-10-25" version="1">MIGMYEQSKAAKRRYRDGDFASRYFVGDGIDVGAGPDGLGRYRRQFAAMRSVREWDLADGDAQLLAGVSDNTFDFLHSSHCLEHMRDAVEALHSWVRVVKPGGYLVICVPDEDMYEQGVYPSRFNPDHKWTFTIQKPQGASWSPRSINLLEMLIPLSGVLEIERIQRVQEFFDDTLHGRDQTLMPNVECAIELVLRKRGAAGAIMGDVRPAAAEGAAAMLPCARAGTGRFDAPAGREALMLLDSGHRDAAERKALEALVREPADCTAMDVLERLYLDSARYAECADILEKLVAYAPNNAGAWNNLGCCYGELRRFPQARAAFQRAVDANPEYVTAYGGLAAMHYALGDPASAEATYRAVLARSPEHVDSCVNLANCMLAQEKVEDARPYIERAGEKLLPDLNKPKDVALCAPREGLTVPYRSRIENRPIFESMHARLGMSLLMLGRATEGLRLLEWRLGSAFVPGFDARRAQRMWRGEPLRGKSLLLLWEQGYGDVLQGLRHVSRLAELAERIYLPADAAVRELFEASFSAWGQKVVVCDWRDEPPAFDYYVSILSLHHRMRELGVACPEAVGPYLSCNPAEVERFRSYRLDENALAVGVIYAGKSEMLLDAQRSLPESVVRDLTAPIAGVRFYSLQIGCRAADCAMLGKMNGVIDWSMLLSRFADTAAAMRALDLVVCVDTAAVHLAGALGVRAMLLNRFGSEYRWQLDRDDGVWYESVSQVRQHAMNDWTNAVACVRSRLRQEALDLGRDAVVPGAQFSASEAGQPDVHRQLRAIEQALGNSQLDEARGLITGYLAQHADSPKAQCHAGVLELLSANPDAARAYLDRAIRLRPDYAVAYSNRAATRKEGDAEREGDIIRSIACDPSFHAGWLNLARIRRPHDAALALQCARRAVQLAPDDADAVLLRAELALDTGDFDEALSQFERLREQRPDAPESYANLIPALAALERRDDAIAALQRALELNSKHPGALNNGVQFYLRTQQYDKAMELAQRYVGAHGELASAHTMCGLVYHNLKAYDRAEASLRRALEIEPHNAEALFALGTVLERVDRLAESEEVLRRALTIRRDYRVLVNLAVTLNRQQRYEAARSLNDEALAIGGGKMKSELKPRMALMRKTFAGQPFRAELATVDMTFGPDWNNALIALVQGDYVRGFAAYELRQEHQTVSGMTADEYRALLWRSEPLAGKRILLLPEQGYGDVIQFLRYVPELKRKGATVLVGASAPLRRLLEVAPGVDEVVQLDDARRPAFDYVCPLMSLAHRLDVSSAEDFLPSFPYLRVPEAASQTWRARFAADSRRKIGLVWAGRKIYPADRLRSVPLPEMRDVLSDIPDVQWISLQVGDCASEAASWPAVLDVSAELTDFAETAALIESLDMVITVDTAVAHLAGALGKPVWMLNRISTDWRWGQEGPRCGWYPSMRIFRQQVHLSWAEPIGELADALEQWLDVERLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UF2</accession>
    <name>Q63UF2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase [NADP+]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gabD</name>
        <name evidence="6" type="ordered locus">BPSL1654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527051.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108264.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1654"/>
    <dbReference type="EnsemblBacteria" id="CAH35651">
        <property type="protein sequence ID" value="CAH35651"/>
        <property type="gene ID" value="BPSL1654"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1654"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1865"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IKYICMS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="23"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="486" mass="51656" checksum="03294C5251C34546" modified="2004-10-25" version="1">MYLEHALKDPSLLRHQAYIGGEWQAADSDATFEVFDPATGESLGTVPKMGAAETARAIEAAQAAWAGWRMKTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAEAKGEIAYAASFIEWFAEEGKRVAGDTLPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVVKPAESTPFSALAMAFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGSTAVGRLLMAQSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHERVYDAFADKLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGKRHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLYSRDIGRVWRVAEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYVVIKYLCVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UF5</accession>
    <name>Q63UF5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL1651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556460.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108261.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1651"/>
    <dbReference type="EnsemblBacteria" id="CAH35648">
        <property type="protein sequence ID" value="CAH35648"/>
        <property type="gene ID" value="BPSL1651"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1651"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3726"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGWTLKW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="264" mass="28496" checksum="911025BDB8869893" modified="2004-10-25" version="1">MLLDFDRLGGLRWALMAVGGAVALFLLLPIAFIVELSFGDSQWLIFPPPGWTLEWYRQLFTDPGWLGSLLTSFELAVIVTFFSVLTGLLASLALVRGEFRGRNAVQAFFLTPMVLPVVVLAVALYAFTLRIGLNGTMAGFVIGHLIIALPFSIISISNSLVSFDTALEDAALVCGASPLEVKLRVTLPAIKLGLFAAAIFSFLASWDEVVVSIFMASPTLQTLPVRIWTTLRQDLTPIVAAASSLLVGLTTVLMLAGALLRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UJ0</accession>
    <name>Q63UJ0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527100.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108226.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1610"/>
    <dbReference type="EnsemblBacteria" id="CAH35610">
        <property type="protein sequence ID" value="CAH35610"/>
        <property type="gene ID" value="BPSL1610"/>
    </dbReference>
    <dbReference type="GeneID" id="56529332"/>
    <dbReference type="KEGG" id="bps:BPSL1610"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3670"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IAQSAMF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="246" mass="25702" checksum="EB135589B886C6AF" modified="2004-10-25" version="1">MSAVAAIVWFDLKRFWASPLRILFGLTQPLLYLFVLGAALRSGTYAEIGGYQAYIFPGVVGLSLMFTAISAAVGIVHDRQTGLLNALLVSPVRRVDIALGKIGAGALLAWLQALLLLPFSPAIGIGLTAPRLALLVAAMAFAALAFSALGLALALPFRSVIVFPVVSNTLLLPMFFLSGGLYPLDLAPDWIRAAAAFDPAAYGVDLMRGVLSAQYAIAPSRSIAALAACLVVAGTLVVRGVGRQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UM5</accession>
    <name>Q63UM5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004196095.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108191.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1571"/>
    <dbReference type="EnsemblBacteria" id="CAH35572">
        <property type="protein sequence ID" value="CAH35572"/>
        <property type="gene ID" value="BPSL1571"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1571"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3621"/>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGLWCAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004630">
        <property type="entry name" value="UPF0324_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00698">
        <property type="entry name" value="TIGR00698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="356" mass="36932" checksum="7D937174DAFAA323" modified="2004-10-25" version="1">MSTLTSPPLSVAAPSMRGRLNGVLFVGLFALAVTSVAQLPAVAHLGLSPLIVGIVAGALYGNLLREGMPASWAAGVDFSARKLLRIAVAFFGLRVSLQEIAQVGVPGLAVSALVVASTLAVGTWAGIRLMKLDRDTALLTAAGSAICGAAAVLAFESALRSKPHQSAMAIGSVVLFGTLSMFAYPLAYRAGWLHLDATGLGLFFGGTIHEVAQVVGAASDVGPEVARVATIVKMTRVMLLVPVLLVLGAWLARSARRSTAAGRGAPRKLAVPWFALGFLGFVIVNSLQMLPAAAIGTLNALDTFALTMAMTALGIETRMSQIRAAGPRALMTGLILYAWLVFGGYAIVWATQRWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UN1</accession>
    <name>Q63UN1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MerR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108185.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1565"/>
    <dbReference type="EnsemblBacteria" id="CAH35566">
        <property type="protein sequence ID" value="CAH35566"/>
        <property type="gene ID" value="BPSL1565"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1565"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1761"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ELMTMYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="349" mass="40100" checksum="3E7BA6FAB172985E" modified="2004-10-25" version="1">MKRRSTMRLKIGELAKRCGLTVRTLHHYDAIGLLKPSARADNGYRLYDRNDIARLHQIQALRRFGLALADVGAYLAQPGTPLASIVSRQIAMLDRQIEQAARLRERLVQLHRELADGAQPELADWLKTLELMTMYDKYFSDEELARLPMYRNRQAPDPEWTALVDAVRALMDAGVAPEDERVRALSVRWMTMLVRDTNGDPRIFAKLNLMHDREPSMQTHVGISPALRDYVLRAFSETKMRIYERYLSPEETRFMRANYGKRAMQWPQLMADVRDAIEAGVTPSSPQGRALAQRWLELFRHYAGDDPATQLKFREALANEPELMTGTWADDALLGFVREAMQHLAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UW9</accession>
    <name>Q63UW9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">hom</name>
        <name evidence="19" type="ordered locus">BPSL1477</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193856.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108097.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1477"/>
    <dbReference type="EnsemblBacteria" id="CAH35478">
        <property type="protein sequence ID" value="CAH35478"/>
        <property type="gene ID" value="BPSL1477"/>
    </dbReference>
    <dbReference type="GeneID" id="56595786"/>
    <dbReference type="KEGG" id="bps:BPSL1477"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3508"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="358"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAH35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="442" mass="47003" checksum="723D13F196A91498" modified="2004-10-25" version="1">MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEIARVAVRNPAKALAALDGDANGVSIGDDFNAVVDDPSIAIVAEMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRERGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISRLAATDIKYAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLADITRILAESGISIDALLQKESEQVDDANGETDIILITHETVEKNVNAAIARIESLATVVSKVTKLRMEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UX0</accession>
    <name>Q63UX0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527177.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108096.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1476"/>
    <dbReference type="EnsemblBacteria" id="CAH35477">
        <property type="protein sequence ID" value="CAH35477"/>
        <property type="gene ID" value="BPSL1476"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1476"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3507"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="412" mass="45841" checksum="EF8EFCA260C28E37" modified="2004-10-25" version="1">MKPIQKSNKLLNVCYDIRGPVLEHAKRLEDEGHRIIKLNIGNLAPFGFDAPDEIIQDMIRNLPASSGYSDSKGVFAARKAIMHYTQQKGVHGVGLDDIYIGNGASELIVMATQALLNDGDEVLLPAPDYPLWTAAVSLSGGTPVHYVCDESNRWMPDPDDIRRKITPNTKALVVINPNNPTGALYSDALLIELIAIAREHGLIIFADEVYDKIVYDGKSHTALASLAEDVITVTFNSLSKSYRSCGYRAGWMSVAGLTAENRRRAHDYLEGLGILSSMRLCANVPGQYAIQTALGGYQSINELIMPSGRLYKQRELAYDMLTSIPGVSCVKPEAALYMFPRLDPKLYPIENDQQFILELLLRERVLLVQGTGFNWPTPDHFRVVFLPNVDDLTDSIERIARFLDGYRKRNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V81</accession>
    <name>Q63V81_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ordered locus">BPSL1360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193912.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107985.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1360"/>
    <dbReference type="EnsemblBacteria" id="CAH35358">
        <property type="protein sequence ID" value="CAH35358"/>
        <property type="gene ID" value="BPSL1360"/>
    </dbReference>
    <dbReference type="GeneID" id="56595287"/>
    <dbReference type="KEGG" id="bps:BPSL1360"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1526"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="84"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="328" mass="34775" checksum="D4418FAA6621174F" modified="2004-10-25" version="1">MSDIPFASTRSGGQAPMRAPSRYGDIVFGGLTRVAAIVTLLLLGGIIVSLIVASMPTIEKFGLSFLWHAEWDPNSDTYGALVPIYGTIVTSIIALVIAVPVSFGIALFLTELSPVWLRRPLGVAIELLAAIPSIVYGMWGLLVFAPIFATYFQKPVGALLGPIPVIGALFQGPPIGIGILSAGVILAIMIIPYIASVMRDVFEVTPVLLKESAYGIGCTTWEVMWKIVLPYTKTGVIGGVMLGLGRALGETMAVTFVIGNTNLLDNVSLYSPGNSITSALANEFAEAAPGLHTSALMELGLILFVITFVVLAVSKLMLLRLERGEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VB2</accession>
    <name>Q63VB2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative malonate decarboxylase alpha-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538429.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107954.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1329"/>
    <dbReference type="EnsemblBacteria" id="CAH35327">
        <property type="protein sequence ID" value="CAH35327"/>
        <property type="gene ID" value="BPSL1329"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1329"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.156"/>
    <dbReference type="eggNOG" id="COG4670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WSGGLYN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005777">
        <property type="entry name" value="MadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16957">
        <property type="entry name" value="Mal_decarbox_Al"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01110">
        <property type="entry name" value="mdcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="548" mass="59742" checksum="F11D5940F80071AF" modified="2004-10-25" version="1">MTGWNEARAARAARLAAAAPLARGKRVAARDATALLEAVLRPGERVCIEGDNQKQADLLAAALAAVDSAKVHGLHMVQSGVVLPEHLDVFERGIAKRLDYAYSGPQSQRIAKLLFGGGIELGAVHTYLELFARYFIDLTPHVALIAAVSADADGNLYTGPNTEDTPTVVEATAFKDGIVIAQVEKIVERVPRVDIPGDRVHFVVEAGRPFYVEPLFTRDPAGITETQILTAMLAIKGIYARYGVKRLNHGIGFNTAAIELLLPTYGERLGLKGQVCTHWALNPHPTLIPAIESGWVEQIHCFGSEVGMDDYIRARSDIFFTGADGSLRSNRAFCQTAGLYACDLFIGSTLQIDLAGHSSTVTAERIAGFGGAPNMGSDARGRRHPSEPWLKAGEEADARTPAALRRGRKLVVQIGETFGEKNAPMFVEQLDALRLADKLALDLAPVMVYGDDVTHVVTEEGIANLLMCRDADEREHAIRGVAGYTEIGRGRDRRLVERLRERGVIRRPEDLGIDALDADRRLLAARSIKDLVHWSEGLYAPPARFRNW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VS1</accession>
    <name>KDPC_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdpC</name>
        <name type="ordered locus">BPSL1173</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186443.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107795.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63VS1"/>
    <dbReference type="SMR" id="Q63VS1"/>
    <dbReference type="STRING" id="272560.BPSL1173"/>
    <dbReference type="EnsemblBacteria" id="CAH35168">
        <property type="protein sequence ID" value="CAH35168"/>
        <property type="gene ID" value="BPSL1173"/>
    </dbReference>
    <dbReference type="GeneID" id="56595104"/>
    <dbReference type="KEGG" id="bps:BPSL1173"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.361"/>
    <dbReference type="eggNOG" id="COG2156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KYFWPRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000022276" description="Potassium-transporting ATPase KdpC subunit">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <sequence length="193" mass="20105" checksum="FE7C90136988EEFC" modified="2004-10-25" version="1">MKSLFRPLIVVFVVLVAVTGLAYPAVMTVFGQAVFPAQANGSLIEKGGRVVGSALIGQQFDAPQYFWGRLSATSPMPYNAAGSGGSNLGPLNPALKDQVKSRLDALKAAGTDLSQPVPVDLVTASASGLDPEISPAAADYQVARVARARKMADADVRRLVADHTSGRQFGVLGEPRVNVLKLNLALDAAQAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VT0</accession>
    <name>Q63VT0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ordered locus">BPSL1164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526434.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107786.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1164"/>
    <dbReference type="EnsemblBacteria" id="CAH35159">
        <property type="protein sequence ID" value="CAH35159"/>
        <property type="gene ID" value="BPSL1164"/>
    </dbReference>
    <dbReference type="GeneID" id="56526698"/>
    <dbReference type="KEGG" id="bps:BPSL1164"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.374"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="425" mass="45419" checksum="972740718C82D0E6" modified="2004-10-25" version="1">MKLLVVGSGGREHALAWKLAQSPRVQLVYVAPGNGGTAQDERLKNVDLSSLDDLADFAESEGVAFTLVGPEAPLAAGIVNHFRARGLKIFGPTKEAAQLESSKDFAKAFMKRHGIPTADYETFTDAAAAHAYLDSKGAPIVVKADGLAAGKGVVVAMTLEEAHAAVDMMLSGNKLGDAGARVVIEAFLDGEEASFIVMVDGKHALALASSQDHKRLLDEDRGPNTGGMGAYSPAPIVTPQMHARVMREIIMPTVRGMEKDGIRFTGFLYAGLMIDRDGNPRTLEFNCRMGDPETQPIMARLKSDFSKVVEQAIAGTLDTVELDWDRRTALGVVLAAHGYPDAPRKGDRINGIPAGTAHAVTFHAGTTFDGDKLVTSGGRVLCVVGLADSVRGAQQAAYETINQINFEGMQYRRDIGYRALNRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W01</accession>
    <name>Q63W01_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550737.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107715.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1094"/>
    <dbReference type="EnsemblBacteria" id="CAH35087">
        <property type="protein sequence ID" value="CAH35087"/>
        <property type="gene ID" value="BPSL1094"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1094"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.464"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEKQMWG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="144" mass="16084" checksum="CEEEB75C1AF0BBD0" modified="2004-10-25" version="1">MQVQPYLFFGGRCDEALKFYGNALGARVNFLVRYRDAPPNPERPTPPEMADKVMHANFQIGDSLLMCSDGDCASGRQQAHDGYSLSLAPKTVEDGKRMFDALLADGGAVTMPFEKTFWALGFGMLRDKFGVHWMINVEDPDMKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W07</accession>
    <name>HTPG_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpG</name>
        <name type="ordered locus">BPSL1087</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185742.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107709.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63W07"/>
    <dbReference type="SMR" id="Q63W07"/>
    <dbReference type="STRING" id="272560.BPSL1087"/>
    <dbReference type="EnsemblBacteria" id="CAH35081">
        <property type="protein sequence ID" value="CAH35081"/>
        <property type="gene ID" value="BPSL1087"/>
    </dbReference>
    <dbReference type="GeneID" id="56595034"/>
    <dbReference type="KEGG" id="bps:BPSL1087"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.471"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000224200" description="Chaperone protein HtpG">
        <location>
            <begin position="1"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="B" evidence="1">
        <location>
            <begin position="340"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="1">
        <location>
            <begin position="560"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <sequence length="632" mass="71149" checksum="F1E905CAD36A6615" modified="2004-10-25" version="1">MTQQTMSFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDAADKLRFEALENNALYESDPNLRIRLSFDKAARTITIDDNGIGMSRDEAIANLGTIARSGTKEFFSKLSGDQQKDAALIGQFGVGFYSGFIVADRITVETRRAGLPASEGVRWESAGEGDFQVDTIERAARGTTITLHLREGEDELLSSYRLKSIVQKYSDHVALPILMKKEEWDQEKGEMVEKDEDETINQASALWTRAKSEVTDEQYKQFYQHVAHDHQDPLAWTHNRVEGRSEYTQLLFVPSHAPFDLWNRDYRGGLKLYVKRVFIMDDAEQLLPQYLRFIKGVVDSSDLPLNVSREILQESRDVKAIREGVTKRALSMLEELANAEDDAGKEKYKTFWSAFGQVLKEGVGEDHANRERVAKLLRFASTHGDTDAQDVALADYVARMKPEQTKIYYVTADTWQAAKNSPHLEVFRKKGVEVLLLTDRVDEWMLSFLHEFDGKPLASVARGDLDLGALNDDEKKAQEETGEAMKPVVDKMKETLGEKVKDVRVTFRLTDSPSCLVADDNDMSGYLQRMLKAAGQSAPSFQPILEINPEHPLVKALKADGADFGDWCHLLFDQALLAEGGALEDPASFVKRTNALLLSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W35</accession>
    <name>Q63W35_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ivy family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204939.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107681.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1057"/>
    <dbReference type="EnsemblBacteria" id="CAH35052">
        <property type="protein sequence ID" value="CAH35052"/>
        <property type="gene ID" value="BPSL1057"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1057"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.504"/>
    <dbReference type="eggNOG" id="ENOG5032SX0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KPHDCAN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043086">
        <property type="term" value="P:negative regulation of catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036501">
        <property type="entry name" value="Inhibitor_vert_lysozyme_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014453">
        <property type="entry name" value="Inhibitor_vertebrate_lysozyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009103">
        <property type="entry name" value="Ivy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89872">
        <property type="entry name" value="SSF89872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266634" evidence="7">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="site" description="Important for lysozyme inhibition" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR009103-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="158" mass="17843" checksum="95CA480F80F16EBD" modified="2004-10-25" version="1">MIRSFFPSSIRRAVLAATIAGIAGAAVAADEPAPTFSEAIAQSAHRAEWKRMISSEKRVPGWLKSDNRVSSPYRREQVEGASYLVGWMCKPHDCAANQFYGVIDEDSHRMWGMLVTLPQTPGAYDAPSKYASFRWFGKPDERMKTYLQDQLKQDPNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W52</accession>
    <name>Q63W52_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198606.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107664.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63W52"/>
    <dbReference type="STRING" id="272560.BPSL1038"/>
    <dbReference type="EnsemblBacteria" id="CAH35033">
        <property type="protein sequence ID" value="CAH35033"/>
        <property type="gene ID" value="BPSL1038"/>
    </dbReference>
    <dbReference type="GeneID" id="56596152"/>
    <dbReference type="KEGG" id="bps:BPSL1038"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.529"/>
    <dbReference type="eggNOG" id="ENOG5032AXU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YTTHYIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="88" mass="9944" checksum="F5AB8BC3C590445B" modified="2004-10-25" version="1">MAGNLVIVCRDQDADAFDQLMQEYGSFQTRLSSTAWYLNMNIVPETLQEDILERVGKYTTLYIFEATSVTYNTIDSNAAETLSTLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W76</accession>
    <name>Q63W76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative biotin biosyntehsis related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107640.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35008">
        <property type="protein sequence ID" value="CAH35008"/>
        <property type="gene ID" value="BPSL1012"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1012"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1097"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDFDWWC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="257" mass="28016" checksum="2E767E75226F43A0" modified="2004-10-25" version="1">MARSTPMKHHDRVADAFGTTASAYLTSAVHATGADLDTFAAEIGATPGARVLDLGCGAGHASFAAARGGAHEVIAYDLAPQMLATVEAAARERGLSNVRIEQGAAERLPFADASFDWIVSRMSAHHWHDVPRALAEARRVLKPGGRVLFVDVAGADHPLVDTHLQAVEVLRDASHVRDYRVDEWLAFFAQAGFAARVRERWRLSIGFDGWVARMRTPDVRAHAIRALWADAPDEVRAYFDVQPDGSFKLDVVMIDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WL9</accession>
    <name>Q63WL9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murJ</name>
        <name evidence="10" type="ordered locus">BPSL0872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550789.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107497.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0872"/>
    <dbReference type="EnsemblBacteria" id="CAH34864">
        <property type="protein sequence ID" value="CAH34864"/>
        <property type="gene ID" value="BPSL0872"/>
    </dbReference>
    <dbReference type="GeneID" id="56526950"/>
    <dbReference type="KEGG" id="bps:BPSL0872"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.724"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="516" mass="55499" checksum="94120735200CE55A" modified="2004-10-25" version="1">MNLFRALLTVSGFTLLSRVTGLARETLIARAFGASQFTDAFYVAFRIPNLLRRLSAEGAFSQAFVPILAEFKNQKGHDATKALVDAMSTVLAWALALLSLAGIAGASWVVFAVASGLRTDGQAFPLAVAMTRIMFPYIVFISLTTLASGVLNTYKRFSLPAFAPVLLNVAFIVAAVFVAPHLKVPVYALAWAVIAGGALQFAVQLPGLKKIDMMPAIGVNPLRALAHPGVKRVLAKMVPATFAVSVAQLSLIINTNIASRLGQGAVSWINYADRLMEFPTALLGVALGTILLPSLSKAHVDADSTEYSALLDWGLRVTFLLAAPSALALFFFAEPLTATLFNYGKFDAHTVTMVARALATYGIGLVGIILIKILAPGFYAKQDIKTPVKIAIGVLVVTQLSNYVFVPIIGHAGLTLSIGVGACLNSLLLFIGLRRRGIYQPSSGWLRFFAQLAGASLVLAGVMRWLAINFDWTAMRAAPLERIALMAACLVLFAALYFGMLWLMGFKYAYFRRRAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-01-20" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WP5</accession>
    <name>T23O_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name type="ordered locus">BPSL0846</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530854.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107471.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63WP5"/>
    <dbReference type="SMR" id="Q63WP5"/>
    <dbReference type="STRING" id="272560.BPSL0846"/>
    <dbReference type="EnsemblBacteria" id="CAH34838">
        <property type="protein sequence ID" value="CAH34838"/>
        <property type="gene ID" value="BPSL0846"/>
    </dbReference>
    <dbReference type="GeneID" id="56526975"/>
    <dbReference type="KEGG" id="bps:BPSL0846"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.753"/>
    <dbReference type="eggNOG" id="COG3483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WRWRNDH"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017485">
        <property type="entry name" value="Trp_2-3-dOase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03036">
        <property type="entry name" value="trp_2_3_diox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="chain" id="PRO_0000360111" description="Tryptophan 2,3-dioxygenase">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="306" mass="34813" checksum="2C27E8FCE42E6F7C" modified="2004-10-25" version="1">MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDHNEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEFILGNKNAQMLRPHAHRPAIHAHLEASLQAPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDRTVEAAWLAVYREPNAHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WQ2</accession>
    <name>Q63WQ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative D-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dalD</name>
        <name evidence="5" type="ordered locus">BPSL0840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.11" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526241.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107464.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0840"/>
    <dbReference type="EnsemblBacteria" id="CAH34831">
        <property type="protein sequence ID" value="CAH34831"/>
        <property type="gene ID" value="BPSL0840"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0840"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.905"/>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GETFIQW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047813">
        <property type="term" value="F:D-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="3">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="4">
        <location>
            <begin position="219"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="480" mass="52115" checksum="F265ADA6502DACF3" modified="2004-10-25" version="1">MIYTKFGGREPAVRRHGMSSPSTAAPAILHIGVGSFHRAHQAWYLHRVNEASPAAERWSLVVGDIRDDLRASREALAAQHGVYTLETVTPQGERAYETIRSIARVLPWSMELAALVDAGAAPACRIVSFTVTEGGYYLDEHDRLDAANPDLAADLQGARLTIYGALAALLAERAARGAGPLTLQSCDNLRNNGARFRAGMRAFLARRGLVELLAWFDANVACPSSMVDRITPRPTPDVRERVRAATGFDDACPVMGEAFIQWVIEDRFAAGRPAWEKAGAELVDDVHPYEEAKIRILNATHSCIAWAGTLAGHSYIHEGTRDAHIRRFAHAYVTDDVIPCLTPSPLDLARYRDVVLERFGNPHIRDTNQRVAADGFSKIPGFIAPTLAESIARGVEPVSTAVLPALFLRFLQRWAQGALPYAYQDGVMDARVARAIAGAADPVAALAGERPLWGALAGMPALERALRAGAARVDAWLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WS5</accession>
    <name>Q63WS5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107441.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0817"/>
    <dbReference type="EnsemblBacteria" id="CAH34808">
        <property type="protein sequence ID" value="CAH34808"/>
        <property type="gene ID" value="BPSL0817"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0817"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.882"/>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WANEMPL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="481" mass="50247" checksum="878A0A677BFFC016" modified="2004-10-25" version="1">MLLLRFVNAHNVEPPSKQNHGVRQMQSNTVHPCDEVLPSGKLLTLGLQHVLVMYAGAVAVPLIVGGALKLPKDQIAFLISADLFACGIATLIQTLGVWLFGIRLPVIMGCTFAAVGPMIAIGTNPGLGILDIFGSTIAAGAIGIVLAPMIGKLLRFFPPVVVGTVISVIGLSLMEVGINWAAGGVGNPNYGDPVYLGLSFIVLALILAINKFGRGFVANISVLLGMIAGFAIAFAAGRVNTDGVAAAPWVGFVAPFHFGLPHFDPLSIATMVIVMFVTFIESTGMFLAVGDMVERPVDQETLVRGLRVDGLGTLIGGIFNSFPHTSFSQNVGLIGVTGVKSRFVCATGGMILVLLGLFPKMAQLVASVPPFVLGGAGIVMFGMVAANGVKVLSKVDFVRNHHNLFIVAVSVGLGLVPVVSPNFFSKLPAAFAPILHSGILLASVSAVVLNIVFNGMKGEKDARCDIRRAGRDFDGQPADLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WT3</accession>
    <name>Q63WT3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="6">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107433.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0808"/>
    <dbReference type="EnsemblBacteria" id="CAH34800">
        <property type="protein sequence ID" value="CAH34800"/>
        <property type="gene ID" value="BPSL0808"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0808"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.873"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPLFNQR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="267"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="384"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="472" mass="49143" checksum="2D50A94DE1FF5FEB" modified="2004-10-25" version="1">MAGTRRAEPQIITPAVAALMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVQRAAQRRAAPQLPIDPDDPFYQFFRHFYGQIPGMGGGRQPQPDDQPSTSLGSGFIISADGYILTNAHVIDGANVVTVKLTDKREYKAKVVGADKQSDVAVLKIDASGLPIVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPVNPGNSGGPLFNLNGEVIGINSMIYSQTGGFQGLSFAIPINEAMKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLQKPDGALVSSVDPKGPAAKAGLQPGDVILAVDGVPVQDSSTLPAQIAGMKPGTKADLQIWRDKSRKTVSVTLASLADDQAKAGVDEPVEQGRLGVAVRPLSPRERNGSSLTHGLVVQQSAGPAASAGIQPGDVILAVNGRPVTSAEQLRDAVKRAGNSLALLIQRDDAQIFVPVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X57</accession>
    <name>Q63X57_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107309.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0680"/>
    <dbReference type="EnsemblBacteria" id="CAH34673">
        <property type="protein sequence ID" value="CAH34673"/>
        <property type="gene ID" value="BPSL0680"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0680"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.741"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYGCADF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="146"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="284" mass="28977" checksum="CD647CF811651125" modified="2004-10-25" version="1">MGLLSALCWGSTDFLAGHAARRVGVTKSLFYSQSFGFLILTASLALHPSSLRITAIDMGFAVGILAAVCNLIAMAALLRALAIGKASVVAPIVSLYGAVTTILSLATGQSITRLAIAGLVLCIVGASLASISKAADGRTESPASIGFALLSAAMFGLGFWLQGAFAVKSLGVVSALWIYYLTAVVILFATLARARNLSAPPGSIVLLILSISVFSLVGFFSLAYGSTTGHVAIVTVLSSLASGVTALLGFFVRGERPSALQWAGIATIIVGVVMLKITPQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X98</accession>
    <name>Q63X98_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis accessory factor UbiJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiJ</name>
        <name evidence="3" type="ordered locus">BPSL0639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiJ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107268.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0639"/>
    <dbReference type="EnsemblBacteria" id="CAH34632">
        <property type="protein sequence ID" value="CAH34632"/>
        <property type="gene ID" value="BPSL0639"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0639"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.694"/>
    <dbReference type="eggNOG" id="COG3165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LEQEPWA"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032150">
        <property type="term" value="P:ubiquinone biosynthetic process from chorismate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02215">
        <property type="entry name" value="UbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038989">
        <property type="entry name" value="UbiJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38693">
        <property type="entry name" value="PTHR38693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="224" mass="24212" checksum="A15869C66015BC21" modified="2004-10-25" version="1">MRGFFIASPMTLAAKPFAAAVNHLLARESWARDRLIPYAGKTARLEISPVTLVLLVQPDGYLAAVEAHDARRFDVSIALSSGADGGAFDAAAAFLQGGQAAVMKHVKIDGDAEFATQIAKLAEHLRWEPEEDLSSVVGDAAAHRIATVVRSAGARARRTGRNVLDSIAEYWLDENPQVVRKSALADFDAGLARARDTLARVEKRIERLEQKIDVRAGGSSRRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XE6</accession>
    <name>Q63XE6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL0590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204835.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107219.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0590"/>
    <dbReference type="EnsemblBacteria" id="CAH34583">
        <property type="protein sequence ID" value="CAH34583"/>
        <property type="gene ID" value="BPSL0590"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0590"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1047"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRRWWVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003284">
        <property type="entry name" value="Sal_SpvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022045">
        <property type="entry name" value="TcdB_toxin_mid/N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03534">
        <property type="entry name" value="SpvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12256">
        <property type="entry name" value="TcdB_toxin_midN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1708"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1740"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1770"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1809"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1851"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="domain" description="TcdB_toxin_midN" evidence="7">
        <location>
            <begin position="565"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="2031" mass="209999" checksum="AB3D7A0196ABB260" modified="2004-10-25" version="1">MAKTSGTADEILNLPSGGGSVSGDGGDFSVDLNTGTATLKFDLTVPAGPNGITPPHTLQYSAGAGDGAFGIGWSLGLMTIRRRITPATGAAEPAPPGACSLVGVGELVDMGARRFRPIVDATGLLIEFTGASWTATDKTDTQYTLGTSANARIGGGALPAAWLVDRCADSAGNAIAYTWLDVGGARVPQAIAWGTYRLDFVYEARPDVLVDGSYGAPVTLDKRCARIELHATTEAPSLVRSWTLLYDDDGGRGRSLLATIREQGHAADGSILAAPERTFAYSSPGAPALVPVTGWTTPLSDPNTDLVDLNGDGLPDIVHLGHGMPTMHPNLGGGQFGAPRPLARTAAPLRLSAPSVAFADMSGNGSVDVLVLDAPFSGYYPLAAPGGSAPAGFGRPIVFERAPAVSPSDVRLRFVDLNGDGITDILLDTGRGWLAYLRDGPASWSDAPRVLPPARTPPVSLADPHVHLADMTGDGLMDIVRVTGGGLTYWPARADGGWDAAIAMTPSPAFGRDFDPHRLALYDVDGDGCADLVYVGLQSVTLWRNVGATRLAAPVAIPGTPVALPGSYRIVDLLGSGTAGVHFQLPSIAGASRQSYLDLGGGVKPYLLTDLAHGAAQSTHIGYRTSTEYARDDAQAGAPWRTYHPFPIQCVARTDQTDHGTGATTSTRYAYHDARYDPATRTFLGFGRVDSEQLGDASCPTLRVETTFHLGLDPADPARPLTGDEALKLGALRRKPLVTATYGLDGSPLEHRPYSITRHAYDALLVASTADNGKRIAVPYCTTSTEERWERQSAAVSARTVDYLAITSEGDVTSQRTRAQRAGIAAPDQDVTTTTTLATGGKNLRLPARVTQTAPGGDIVSESICFYDGDAFAGLPEGQATRGLVTRIEDRVFDDAFVASVWGDTPPDLTQYGYHRLPGEAGSWWKTRRAHARGANASGPTLATKGPLGALQTLQYDASGQRVVKVIDALGNAVAATTDARVFQTASLTDANGHRTADAFDALGRVVATIGPLDTPALPTIAFTYTVGAISTVTSATRGTHGGADAVPALTWIDGAGNVLGKGTPAAAPGEWTVTHAVRRNARGLVAASFLPYAATGANWQPPPADTGATTSTYDALGRLVQLTRPDGLVVTSRREGDTLITSETWPGGAALDVERQVYDAAGQLVSVSRNAGDHWVEQRYAYAPSGKVRDVTLPGGAHVAFTLDLLGRVFAQQSPDTGRTVFLLDASDNQRARTNAAGQIVRTEVDAMNRATNVYHDAEPAPRVRYEYADASGAPPADGIVANRYTRLWRITDEIGTVDFEYDEAGRKTATTRTVAATGQRFVTRRAYDALGRLARATLPASAPGGAARTIAYGYAADGRLVSASGVVKDAAYDRFGRLTSIDYENGASTLIDYAANAGGIARVRVLDAARNVLRDTTLTRGGGLVQTLASAHAGDDSVDFGYDPLRRLTSAHYRQGATAADAHDWTFDDAFNATAATDAGVLTYEPGTHRLASVGGAAVAFDVAGRMTSGRFGAATFDAADHLSAVTLPDATHIAHTYDYQGRRVRSTKNGAQTYFSPIEDIEFQGDTAIVWITFGKQRIAADIGGALTFVHPNALGVMDLITDSGGAYGTRVRQTPFGYARAADGAAPAGGVAAVALALGAADATGLVCHGLRWYDPCVGQFISPDPVVTSVYTVGAWNPYVYCLGNPILLADPNGCSFLSVLEIIGVAILAAACVVGAIFTGGATLVALGVLSANIGGWLLAGVALGSLGGAIAGELAAQKAGGNLWAGAFLGAFLGGATSLIGGALGGAAAAGIDTLIGGTKTFLSFVAAGAIQGTLAGAGTGLAIGYAGGKGNAESMLIAMAKGAAWGAVLGTLLGAGIGAIAGTGISGAAKPDNFLNIGAFGQKFADFTSTSTAINSADNAAGVTESLAQLSMPNGFNAGNLLGLLPNLVTTNEQAAGWFSIPIGWLGPGVLNDAGFAGLVDTSMALDQAGFSYAHQISLLLGAAPYFIDYAATMAQIVDANGVNNFEMAFNNAFGSGSPSNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XP0</accession>
    <name>Q63XP0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204811.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107125.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0500"/>
    <dbReference type="EnsemblBacteria" id="CAH34489">
        <property type="protein sequence ID" value="CAH34489"/>
        <property type="gene ID" value="BPSL0500"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0500"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.558"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DVIPRPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004866">
        <property type="entry name" value="CHB/HEX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03173">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267675" description="Beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="CHB_HEX" evidence="8">
        <location>
            <begin position="59"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="833" mass="90962" checksum="C2447AD83A0B3E19" modified="2004-10-25" version="1">MNRVPHSLCAALLAAATLLPTASRAQLPARPTAGAAAPATAAPVRPASTPAELAARLANGLAVRVAVDNNHAASAGVPCADLGADWASCATGRLILQNRGHSPLTDGGWKLYLHSIRRLLRIDRPGFTLRHLTGDLYELTPQPGTVRLAQGERIELPFVAEYWLRRYSDVIPRPYVVVDGAAPAVLRYDDTDDELRYVETLPADAQNNSPGNAPPAAAQPVANRALPSVKRQRALPGALDLRGVELTLPELPSAQVAALRERAGTLGLDGARVPVWGVVAPRRLPADIAVPGGYRLAIGPRGAFIEGADRAGLYYGVQTLFSLVPAGGATVPAMLIEDAPRFTHRGMHVDLARNFKPPATLRRLIDQMSAYKLNRLHLHLSDDEGWRIEIPGLPELTDVGARRCHDPSETRCLLPQLGSGPDDRSGGGYLTRDDYVALLRYAAERFVEVIPEIDMPAHSRAAVVSMEARYRRLHAAGREREANAYRLLDAQDTSNLLTVQFYDRRSDLNPCMPGALNFASKVIREIASMHADAQAPLRIWHFGGDEAKNILLGAGFQPLDGADPGKGRVDLAAQDKPWARSPACTALLRRGEIKSIDELPTRFAKQVSAIVNANGIGTMAAWQDGIKHASGPREFSTRHVMVSLWDTIFWGASDSARDLSAKGYRTVLALPDYLYFDFPYTRNPRERGYYWGSQATDEYKVFSLAPENLPQNAEVFGDRDGNPFEVTSAGAAPSIEGIQGQAWGEVMRNGQLLEYMVYPRLLALAERAWHKADWELPYAAGVRYKLGDTHHVDTAALERDWAGFATVLKQRELPKLERAGIGYRKPTFTLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y07</accession>
    <name>Q63Y07_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL0382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107008.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0382"/>
    <dbReference type="EnsemblBacteria" id="CAH34370">
        <property type="protein sequence ID" value="CAH34370"/>
        <property type="gene ID" value="BPSL0382"/>
    </dbReference>
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    <dbReference type="KEGG" id="bps:BPSL0382"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1285"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF110997"/>
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    </dbReference>
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        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="28875" checksum="42335D3B367AEB63" modified="2004-10-25" version="1">MAKPRRTSKQSKQAGGTFLGIVLGLIVGLAIAVVVALYITRAPSPFVSKVAPPADNNASQPQQFDPNRALQGKTPGQPVTPQAAQPAPPNTAPGQAANPSQPPLLPEPQIVEVPSSNNNGNGSPSASNNAADNGVAVAPKPAEPAPPPAKKPQTAANGSSAPHVANNNAQASAAATPPKAAQAPKGASSATTTAAKPTSGADANTGYFLQVGAYKTEADAEQQRARLGFQGFESKVSKRDVSGVTYFRVRIGPFSKFEDMNSARQRLSDAGVDTAVIRFTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y15</accession>
    <name>Q63Y15_BURPS</name>
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        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">BPSL0374</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
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    <dbReference type="SMR" id="Q63Y15"/>
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        <property type="protein sequence ID" value="CAH34362"/>
        <property type="gene ID" value="BPSL0374"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|272560.51.peg.1294"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="359" mass="39517" checksum="F241C34FF85B49D1" modified="2004-10-25" version="1">MNALEHQLDYPFADALPEPGGFVEVAPGVRWLRMPLPFALDHINLWLLRDEIDGQAGWTIVDCGIASEQIKAHWERIFDAHLDGLPVLRVIVTHCHPDHFGLANWLCDGGARARWNVRLWMTLGEYLFGCVMAAGNGSNAGGPAAADHFARHGLADPAALDKLRNRRGYYADLVPAVPPRYRRLREGDALAIGAREWRVVTGYGHSPEHCALHCAADGMLISGDMVLPRISTNVSVFDLEPEANPLALYLESLGRYEAMAEGTLVLPSHGLPFRGVRTRIAQLRAHHDARLAEVRAACRERPMSAADIVPIMFKRGGLDIHQMTFALGEAIAHLNLLWLAGELARETGADGVLRFRHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YB9</accession>
    <name>Q63YB9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative flagella basal body P-ring formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
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                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
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            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0269"/>
    <dbReference type="EnsemblBacteria" id="CAH34257">
        <property type="protein sequence ID" value="CAH34257"/>
        <property type="gene ID" value="BPSL0269"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0269"/>
    <dbReference type="eggNOG" id="COG1261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARMNTGY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017585">
        <property type="entry name" value="Flag_basal_body_FlgA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039246">
        <property type="entry name" value="Flagellar_FlgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041231">
        <property type="entry name" value="FlgA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36307">
        <property type="entry name" value="PTHR36307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13144">
        <property type="entry name" value="ChapFlgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17656">
        <property type="entry name" value="ChapFlgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03170">
        <property type="entry name" value="flgA_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SAF" evidence="5">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="307" mass="30934" checksum="36C03E878EDE9D6D" modified="2004-10-25" version="1">MSAASRAPATTDMQRVAPVIAQDEGAAPAGRPANARAAAQSWPARDPSVAAGGVIPVSLRAQPAPRTLPVRSAPIRAAATSAAGAQPAAASATAAGAVPAAQQDGESIRRAALAFLQQQAAGLPGKTTVTVAPAFPRGLAACTTLEPFLPSGARLWGRTTVGVRCAGERPWTIYLQAKLAVQATYYVAARQIAPGETLTAADLVARDGDLTLLPLAVITDAQQAVGATALTRVAAGLPLRRDLLKSAASVSIGQTVRVVASGQGFTISAEGSVLNNAAPGQQVRVRMAAGQIVTAIVKDAATVEIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YF7</accession>
    <name>Q63YF7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fliF</name>
        <name evidence="14" type="ordered locus">BPSL0230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523066.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106858.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0230"/>
    <dbReference type="EnsemblBacteria" id="CAH34218">
        <property type="protein sequence ID" value="CAH34218"/>
        <property type="gene ID" value="BPSL0230"/>
    </dbReference>
    <dbReference type="GeneID" id="56527528"/>
    <dbReference type="KEGG" id="bps:BPSL0230"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1482"/>
    <dbReference type="eggNOG" id="COG1766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NYEVNRI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="83"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="288"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="598" mass="63433" checksum="A340D65B55CD23D2" modified="2004-10-25" version="1">MDSQANSLINPDARSSLAGASPQAAAAAGALPGAAAGGADFGLGGFAERIPGLSRMKTNPRLPFLIGAALAIAAIVALVLWSRAPDYRVLYSNLSDRDGGAIIAALQQANVPYKFADAGGAILVPANQVHETRLKLAAMGLPKGGSVGFELMDNQKFGISQFAEQVNYQRALEGELQRTVESINAVRAARVHLAIPKPSVFVRDREAPSASVLVDLYPGRVLDEGQVLAVTRMVSSSVPDMPAKNVTIVDQDGNLLTQTASATGLDASQLKYVQQIERNTQKRIDAILAPIFGAGNARSQVSADVDFSKIEQTSESYGPNGTPQQSAIRSQQTSSSTELAQSGASGVPGALSNTPPQPASAPIVASNGQPAGPAATPVSDRKDSTTNYELDKTVRHVEQSMGTIKRLSVAVVVNYQPSTDAKGRVTMQPLAADKLAQVQQLVKDAMGYDEKRGDSVNVVNSAFSAAADPFANLPWWRQPDMIELGKDIAKWLGVAAAAAALYFMFVRPALRRAFPPPAEPAAAAVPALDGPDDMLALDGLPSPDKKQLAEEDEEHPALLAFENERNRYERNLDYARTIARQDPKIVATVVKNWVSDER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YJ8</accession>
    <name>GATB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatB</name>
        <name type="ordered locus">BPSL0189</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552444.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106817.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63YJ8"/>
    <dbReference type="SMR" id="Q63YJ8"/>
    <dbReference type="STRING" id="272560.BPSL0189"/>
    <dbReference type="EnsemblBacteria" id="CAH34176">
        <property type="protein sequence ID" value="CAH34176"/>
        <property type="gene ID" value="BPSL0189"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0189"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1530"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241203" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <sequence length="490" mass="53337" checksum="075359587D1D9A69" modified="2004-10-25" version="1">MTQWEVVIGLETHAQLSTVSKIFSGASTQFGAQPNTQACPVDLALPGVLPVLNRGAVERAIRFGLAIGATVAPRSVFARKNYFYPDLPKGYQISQYEIPVVQGGQITIQVPANEKAGKQAYSKTVNLTRAHLEEDAGKSLHEDFAGMTGIDLNRAGTPLLEIVTEPEMRSAAEAVAYAKALHGLVMWLGICDGNMQEGSFRCDANVSVRPVGQEKFGTRAEIKNLNSFRFLEDAINYEVRRQIELIEDGGEVVQETRLYDPDKRETRSMRSKEDAHDYRYFPDPDLMPLVIGADWIARVKGEMPELPAAMQQRFIEQYGVSAYDAGVLTSTKAMAEYFEALVAKAGAANAKLAANWLMGDVSSQLNRDGIDIDACPVSAAQLALVLQRIADGTISNKIAKEIFVTIWDEKAADEGAADRIIEAKGLKQISDTGALEAIIDEVLAANAKSVEEFRAGKDKAFNALVGQAMKATKGKANPQQVNELLKKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YZ6</accession>
    <name>Q63YZ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative outer membrane porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL0044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204735.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106669.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0044"/>
    <dbReference type="EnsemblBacteria" id="CAH34027">
        <property type="protein sequence ID" value="CAH34027"/>
        <property type="gene ID" value="BPSL0044"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0044"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1699"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LGNQYDF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0626">Porin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266683" evidence="5">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="6">
        <location>
            <begin position="5"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="366" mass="38661" checksum="3D52A0176C8D42B0" modified="2004-10-25" version="1">MKKFAVAAAGLAVATGAHASDGSVTLFGLIDAGVSYVSNEGGKRNVYFDDGIAVPNLWGLRGTEDLGGGAKAIFELTSQYALGNGAALPTPGSMFSRTALVGLWSERLGSVTLGQQYDFMTDSLTFGSFDGAFRYGGLYNFRQGPFSKLGIPDNPTGSFDFDRLAGSSRVPNSVKYTSANLNGLVFGLMYGFGNQAGGGLAANSTVSAGLKYETGSFALGAAYVEVKYPQMNNGHDGLRNWGLGARYALSAFDLNLLYTNTRNTLTGAAIDVIQAGVRYVGAPWTIGANYEYMKGNAQLDRNYAHQVTATAQYALSKRTSAYVETVYQYAGGSAGAHAWINGVMGPDAQSSSRSQFLARIGMLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z09</accession>
    <name>Q63Z09_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar motor switch protein FliN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliN</name>
        <name evidence="9" type="ordered locus">BPSL0028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184995.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106653.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0028"/>
    <dbReference type="EnsemblBacteria" id="CAH34011">
        <property type="protein sequence ID" value="CAH34011"/>
        <property type="gene ID" value="BPSL0028"/>
    </dbReference>
    <dbReference type="GeneID" id="56594161"/>
    <dbReference type="KEGG" id="bps:BPSL0028"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1718"/>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="THNDIDM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="8">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="165" mass="17311" checksum="15B10F621764F5FA" modified="2004-10-25" version="1">MTELNSTPEADGIDEPAFADTAMSAAAAGNAAGAAPQEEMAMDDWAAALAEQNQQPIETGATGAGVFRPLSKATASSTHNDIDLILDIPVKMTVELGRTKIAIRNLLQLAQGSVVELDGLAGEPMDVLVNGCLIAQGEVVVVNDKFGIRLTDIITPSERIRKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H7C734</accession>
    <name>H7C734_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlB</name>
        <name evidence="7" type="ordered locus">BPSL2686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004522250.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109282.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2686"/>
    <dbReference type="EnsemblBacteria" id="CAH36694">
        <property type="protein sequence ID" value="CAH36694"/>
        <property type="gene ID" value="BPSL2686"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2686"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2656"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="3"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="353" mass="39132" checksum="1DA3CBCCB93BBE89" modified="2012-04-18" version="1">MILVTGGAGFIGANFVLDWLAQSDEAVLNVDKLTYAGNLGTLKSLQGNPKHVFARVDICDRAAIDALLAQHKPRAIVHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSALGPDAKAAFRFLHVSTDEVFGSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPVLTTNCSNNYGPYQFPEKLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVLARGVPGETYNVGGWNEKKNLDVVHTLCDLLDEARPKAGGSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGLAKTVRWYLDHQEWVDEVVSGDYRKWVETNYAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HS5</accession>
    <name>Q63HS5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS2345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552304.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112347.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2345"/>
    <dbReference type="EnsemblBacteria" id="CAH39831">
        <property type="protein sequence ID" value="CAH39831"/>
        <property type="gene ID" value="BPSS2345"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2345"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5985"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WCVIWLS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="387"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="628"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH39831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="760" mass="82237" checksum="608EC90BD390CA60" modified="2004-10-25" version="1">MTPERPDASRSTSPDNDDWEDDASFAPGAPEHDFAVRRVTLIVMLVAAIVLPCVYVAVMAYNDMRTREATARDVTMRTVRVAEEHALKVFDLSETLDARIVDLVQDLDDAAVRNAEADIHDALNTIGGGYPQVASVSIFGASGMLLANSLYYPAPYASIAERDDFVGIRDGKVIEHISRVMPGPLKAANPGPVFNTGVARRHSDGTFAGMVSIALKSSYFNAFYRDLLGGADAPMSMALTRTDGAVLASYPPASRGAPDDAASQADSANPFGGAQGDQHAGIVRVKRDGDSEIVAYRQVGSYPVFVSCAYRTSAIRHAWYEHLSVLFISMFAPSAALWGVIWLSLKRLRAEEQAWERWQAEASMRRSIESAYRQSRKMETLGNLVGSVAHDFNNLLMIISSNVQIARRRGVQHLDTELAAIERALKNGQSLTRQLLGVARKQPLRSETIDIAHWLASCRELLKTSLGSKSTLAVDTQLDLWPVRVDVAELELAVINLAVNARDAMPQGGRFKISAHNITFRREDGFPLTGDFVQISVEDTGLGMSPEVLARAFEPLFTTKAKGMGTGLGLPQVFAFCERSGGLATIDSEVGAGTSVRLYLPRTTDAVPPVDAPNAADNLAASTPAGLRILLVEDNGEVAAGTEALLELLGHQVTHAPNADDALRMLNAAGAEPGAPGTFDLVISDIHMPGTINGIDLAEAIERGDMKLPVILVTGYAEEFDRTRRVHARLLSKPFDIALLDDLLQKIQHERDARLAGHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I33</accession>
    <name>Q63I33_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112239.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2236"/>
    <dbReference type="EnsemblBacteria" id="CAH39722">
        <property type="protein sequence ID" value="CAH39722"/>
        <property type="gene ID" value="BPSS2236"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2236"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6666"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KDEDHHL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="213" mass="23326" checksum="CD23EB96E922E407" modified="2004-10-25" version="1">MGRGPAETEAAMAKKQLGEGVRELLYQALETELGGAKVYEAALSVVTDEALREEWQKYRDETLHHQEVLRSVFDALGLDPDEKTRGRAAVAGLGKALVEVIAYARGGGNPLVAQIVAAECVVLAETKDHLNWELIGLAAGELSGDAARVLKDAHDEVEPDEDHHLYHTRGWTRELWMDSMDFKAALPPPEEVRKVDTAIGAARAEHARGRMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IC3</accession>
    <name>Q63IC3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS2148a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112149.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2148a"/>
    <dbReference type="EnsemblBacteria" id="CAH39632">
        <property type="protein sequence ID" value="CAH39632"/>
        <property type="gene ID" value="BPSS2148a"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2148a"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5719"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AEFKHEA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="100" mass="11504" checksum="BD14188986AA5358" modified="2004-10-25" version="1">MVRRAFSEEFKEEAIRLVVEQGYPFSKACGAVGIGETALRRWVAQWRAAHSLDVPSPAQLSADARRIKELEARVAELEREREVLKKSTAFFVKELERSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q63II6</accession>
    <name>Q63II6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS2085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524825.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112086.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2085"/>
    <dbReference type="EnsemblBacteria" id="CAH39565">
        <property type="protein sequence ID" value="CAH39565"/>
        <property type="gene ID" value="BPSS2085"/>
    </dbReference>
    <dbReference type="GeneID" id="56532184"/>
    <dbReference type="KEGG" id="bps:BPSS2085"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5628"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SPKAFLM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="414" mass="45330" checksum="69E4F7AF5D1BC0D4" modified="2004-10-25" version="1">MASVVLKGVSKAYGGSPPIVRDIDLDITEGEFCVFLGASGCGKSTLLRMIAGLEDVTDGDIYIGSQRMNLIPPARRGVAMVFQSYALFPHMTVYENLSFGLTLSGIAKATVREKVLNVAHALQIEHLLDRTPRALSGGQRQRVAIGRAIVREPGVFLFDEPLSNLDAALRVQTRHEIARIHREIGHASTIYVTHDQVEAMTLADRVVLLNSGETARKVGSLAQSGSPLELYYHPRNRFVAEFIGSPKMNFINAELMDAGEHLAKVRLASGDVLSARVDARVLDPGASLTLGVRPEDLALGTQTQHFVREVMWQERLGEATYVYLNGGDAGSHWIAKLPGTTNVSAGQRLPLSVPPDKLYAFDARGNALRRCLDQRTSITTVPMTECAFVDQDDSSMVARMHADGHYITSKRHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IP1</accession>
    <name>Q63IP1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS2028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524888.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112031.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2028"/>
    <dbReference type="DNASU" id="3096658"/>
    <dbReference type="EnsemblBacteria" id="CAH39506">
        <property type="protein sequence ID" value="CAH39506"/>
        <property type="gene ID" value="BPSS2028"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2028"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5555"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARQYLSM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="224" mass="24954" checksum="B5CE41AB5C92D224" modified="2004-10-25" version="1">MSAIPQAARKRGRPVKGESATLRDELILKSAKLFRTQGYERTTVRDIAAAAGVQAGSWFYYFKTKQDILVAVMEQGMSNALARIEALDVEHLPARDAFRALVHTHLHTLVSPDHDFIPVLLYEWKSLDEAMQAKVLKLKDRYEAVWDGVIERLQAAGEWPAPTPIDRLLMFGALNWVAQWYKPDGALGLDALAEHAVRFLLRTAETPAPAPAGTAKRRRGVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW0</accession>
    <name>Q63IW0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">BPSS1956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004540302.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111962.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1956"/>
    <dbReference type="EnsemblBacteria" id="CAH39434">
        <property type="protein sequence ID" value="CAH39434"/>
        <property type="gene ID" value="BPSS1956"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1956"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5447"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMMQKEN"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="327"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="392" mass="41738" checksum="4C601FA509D1ED53" modified="2004-10-25" version="1">MSEPLLLTFNAGSSTLKIGLYSVANGEPAPLGRGKIDFNRAPLQFEYANGGEAHAVPLAAPVTDDLHAVLDEALGWIDAHLSVHELVSVGHRVVHGGDTFDGPVRIDERTLDAIAALVPLAPLHQPQSVRLIRALRHVRPHLPQVASFDTAFHRTQSDLVRRFALPRALFDAGIKRYGFHGLSYRYVAGRLRERHPSIARGKVVAAHLGSGASLCALDAGVSRDTSMGFSTLDGIPMATRCGALDAGVVLHLQKTLGRTLDDVEQMLYHRSGLLGVSGVSGDARALLADPSAGARDALELFAFRIAGETARLAATLGGLDALVFTAGIGEHQPQTRAAVCERLRWLGVELDAHANARNAETVSRDGSRVAVLVVPTDEEQVIARDAASVLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IW2</accession>
    <name>Q63IW2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009950383.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111960.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1954"/>
    <dbReference type="ESTHER" id="burma-q62eb8">
        <property type="family name" value="PhaC_cen_dom"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39432">
        <property type="protein sequence ID" value="CAH39432"/>
        <property type="gene ID" value="BPSS1954"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1954"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5445"/>
    <dbReference type="eggNOG" id="COG3243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GVERHHE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010941">
        <property type="entry name" value="PhaC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022211">
        <property type="entry name" value="PHBC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07167">
        <property type="entry name" value="PhaC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12551">
        <property type="entry name" value="PHBC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHBC_N" evidence="5">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PhaC_N" evidence="4">
        <location>
            <begin position="108"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH39432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="597" mass="65869" checksum="B3B18F4132D1E959" modified="2004-10-25" version="1">MDTRHAPESGAPDAPLPAHPPASYAPESPYRIFDLAKEASVAKLTSGLSPASLQLALADWLIHLAAAPGKRAELATLALRHAALLGQYLLEAATGRTPAAPAQPSPGDRRFRAGAWQLEPYRFWHQSFLLAEQWWRAATRDVPGVSPHHEDVVAFSARQMLDTFAPANYVATNPEIAQRTALTGGANLAQGVWNYLDDVRRLITKQPPAGAEQFELGRNLATTPGRVVFRNHLIELLQYSPTTPDVYAQPVLIVPAWIMKYYILDLSAHNSLIRYLVGEGHTVFCISWRNVDASDRDLSLDDYRKLGVMDALDTIGAIVPGEKIHATGYCLGGTLLSIAAAAMANTGDDRLASITLLAAQTDFAEPGELQLFIDDSEIHFLESMMWERGYLGAHQMAGSFQLLMSNDLIWSRVIHDYLLGERTPMIDLMAWNADSTRMPYRMHSEYLRHLFLDNDLATNRYVIDGQTVSVHNIRAPFFVVGTEHDHIAPWRSVYKIHYLSGSDVTFVLTAGGHNAGIVSEPGHAKRHYRMKMTAAAAPSISPDEWLAGATDFEGSWWPAWHAWLARHSSPQRVAPPPLGKPGARTLGDAPGTYVFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J06</accession>
    <name>Q63J06_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525018.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111916.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1910"/>
    <dbReference type="EnsemblBacteria" id="CAH39388">
        <property type="protein sequence ID" value="CAH39388"/>
        <property type="gene ID" value="BPSS1910"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1910"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5380"/>
    <dbReference type="eggNOG" id="ENOG5032TV9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ASERFTH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="350" mass="35796" checksum="D0E57E8BB6361287" modified="2004-10-25" version="1">MIRAARSALAARAGRAFDLPTLGRTLAVCAPTIALYGATGDARWLLASIATVSIAIAVERVGIAPLGALAQGAAIVAGFLSLSCALSAWPAFVAGCATLAAAAVALSRCGARLRSLGNFVFIPSLYLTCEAAAAHHSATRLVPYLGAAMLPAIALSGVQAWRNAPAAHRLHALARWRGARELGRPAASSDAAQAIVAVALAVAAAALLVEWRHIDNGQWAIWSAASVVTGDAATARVKLRDRGLGALAGVPLGLAAGHALPHGALVYTLATLASVLTLVAFRHYATGFGARCACIACASWVAQQSTAIAAERVVNVLAGGLIGIACVLATHWFATRPLTRRHNARANRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J43</accession>
    <name>Q63J43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111879.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1874"/>
    <dbReference type="EnsemblBacteria" id="CAH39351">
        <property type="protein sequence ID" value="CAH39351"/>
        <property type="gene ID" value="BPSS1874"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1874"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6216"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IAQAPAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="180" mass="19372" checksum="EDEB8CC343F6BAAB" modified="2004-10-25" version="1">MTGKAEPIMLFLLFHLDGERYALDAAEIAEVLPLAATKTIPGAPAWAAGILMYRGEPVPVIDVPRLALGRRAQPLRSTRLVLVRYRLPAAAEPAFVPPRVRLLGLIVERATQTARIAREAFRDSGFATPHARWLGPIASDADGVVQWVALRHIVDGEARALLFDYAASLDAHGAPAGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JB8</accession>
    <name>Q63JB8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190743.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111804.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1800"/>
    <dbReference type="EnsemblBacteria" id="CAH39276">
        <property type="protein sequence ID" value="CAH39276"/>
        <property type="gene ID" value="BPSS1800"/>
    </dbReference>
    <dbReference type="GeneID" id="56598232"/>
    <dbReference type="KEGG" id="bps:BPSS1800"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5241"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FTRLMQT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="312"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="412" mass="44574" checksum="E121AA25AEBDD37F" modified="2004-10-25" version="1">MANVGKAWNIDDLRKMARKRVPKYFFDYLDGGANSETTMRANENDFARWRLRQKVLTGAQSRVAGLGATYLGAEHRLPILLGPVGFAGMYWSRGEIAAGRAADDAGIGQCLSTFSICSLEDVAAARSGPLYFQLYMFRDRDLTEDILARCRLANVDAVFLTVDTCYIPIRERDARNGFRADTRLSARGVWSMLKRPGWCAGALSHGVPRIGNVLRYPELGASLLEQSAAVGRMIETRLSWADVKWLRARWPGRIVIKGILDPDDARRAVDEGVDGILISNHGGRQLDPAPSVMDVLPEIAEAVGKRTEILMDGGVRRGADVIKALALGASAVSIGRAYVYGLGAAGEKGVSRCLELLKGEMLPALNMMGFESIAELRAAGKSALRMAVPVHGATAVVEGAEGGARRLTESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JD3</accession>
    <name>Q63JD3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1785</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111789.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1785"/>
    <dbReference type="EnsemblBacteria" id="CAH39261">
        <property type="protein sequence ID" value="CAH39261"/>
        <property type="gene ID" value="BPSS1785"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1785"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6104"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AMSATLW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH39261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="229" mass="23791" checksum="29E54B916022DB47" modified="2004-10-25" version="1">MPPRLWISITALGGAGLTLPLAVTIAVWLALGYSLRRAAAWLAVLGTAIGAVALTKIAFLGWGIGVRAWDFTGFSGHAMLSTSVYPVAMFLALARARPAVRVAGVVVGLAAGVAVGLSRVALDAHSPSEAVTGCVIGALAALSFIAGSWRAMPHRWSAPAVATSLVAVTIALHGITVPSHRWVTAVALQLSGHERPYVRARWKANPNYRPASRPTQQQTLGAPAAVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JS2</accession>
    <name>Q63JS2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556298.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111650.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1644"/>
    <dbReference type="EnsemblBacteria" id="CAH39118">
        <property type="protein sequence ID" value="CAH39118"/>
        <property type="gene ID" value="BPSS1644"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1644"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5036"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LDLINMF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH39118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="465" mass="47755" checksum="56D5F0E3355ED396" modified="2004-10-25" version="1">MSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALRASVAQLAWVGNIYMLGLTVVIPLGAWLAHRFGERRLLTASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHASWRVVFWGMLALAASTCTLALAWLPADVARDAPRPLDAAGLGLSAAVLVALLLGLAFASRRGEGAPAIAMLALACTAGVAYVRHARRSSAPLLDLALLSQPLLRTGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVGALMVPWAAASFAAIATTRRAFPAVGARPLLACGVVADCIGIALLATPLAVHEAGRVLAYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLSFCLGVAVLGGMLNFLLAAGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JV3</accession>
    <name>Q63JV3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528894.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111619.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1611"/>
    <dbReference type="EnsemblBacteria" id="CAH39086">
        <property type="protein sequence ID" value="CAH39086"/>
        <property type="gene ID" value="BPSS1611"/>
    </dbReference>
    <dbReference type="GeneID" id="56529977"/>
    <dbReference type="KEGG" id="bps:BPSS1611"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4997"/>
    <dbReference type="eggNOG" id="ENOG5030WSW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SHYAEHG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010261">
        <property type="entry name" value="Tir_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05932">
        <property type="entry name" value="CesT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="17253" checksum="7C53F6423EF9F945" modified="2004-10-25" version="1">MSWERYAQVVAQVCAVVDLPDVDYVLETRTIDVEGFDVRIEYFDDDPESMYVNFHYGIVSAGRTLTVYRLLLEANLLIYAQDQAQLGIDADTGSIVLLMRLPLTPDVTGETVADLFAHYAEHGRYWRQNIIESGDEMFDAIASGEYFWLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K43</accession>
    <name>Q63K43_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bicP</name>
        <name evidence="1" type="ordered locus">BPSS1523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187648.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111529.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1523"/>
    <dbReference type="EnsemblBacteria" id="CAH38996">
        <property type="protein sequence ID" value="CAH38996"/>
        <property type="gene ID" value="BPSS1523"/>
    </dbReference>
    <dbReference type="GeneID" id="56597867"/>
    <dbReference type="KEGG" id="bps:BPSS1523"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4877"/>
    <dbReference type="eggNOG" id="ENOG5033IR1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TELANMY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010261">
        <property type="entry name" value="Tir_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05932">
        <property type="entry name" value="CesT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="151" mass="16308" checksum="ECE364A3E36B418E" modified="2004-10-25" version="1">MNTHTEWLNALSEAAGVPLEFDEHGQCFVLLDTQLMISIRDRPDALVLYGMVGEFAEHAPAQCWKRMLAVNLDLSEAGRGGLGLDDETGAVMLIERVATANLGGREFVDVFEAFASRVESLIDTFEQAGAYDADARGLPADSHAAARALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KA1</accession>
    <name>Q63KA1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSS1465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004546917.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111471.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1465"/>
    <dbReference type="EnsemblBacteria" id="CAH38936">
        <property type="protein sequence ID" value="CAH38936"/>
        <property type="gene ID" value="BPSS1465"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1465"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4799"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MGTFWRV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH38936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="409" mass="43463" checksum="966A8B7EB3BE3F77" modified="2004-10-25" version="1">MSKTSIEWSPGARLNRCRASGATMGTRYGAQFYAPPTADARAIAAALDAAVRAVDAQMSNWKADSDLSRLNRATPGSWTPICANLAAVLVRAREIGRETDNAFNIGVGTLVDRWGFGPGAAANRQADNEWAANRQAAGRHTVDRRTVARHMVDRHMVDRHTVDRHTADRQTADRQTKDGRTPDRQPARPAGPANGLSGAIDARRRTSILRSPVPSPCRPIDELLEVDVARGRARRLADVAFDLCGIAKGFGVDELARVLDRHGIGAWLVGIDGELRARGCKPDGSPWAIALEAPDYDRRGAMGAIDLVDAAVATSGDYRHWADFGGERLSHTMDPRAGAPLRGDIASVTVVAPTCTDADAYATALMVLGAQAGCAHAERHGLDALFVVRDGDALRTIGCGAFADAGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KB5</accession>
    <name>Q63KB5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004201020.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111457.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1449"/>
    <dbReference type="EnsemblBacteria" id="CAH38920">
        <property type="protein sequence ID" value="CAH38920"/>
        <property type="gene ID" value="BPSS1449"/>
    </dbReference>
    <dbReference type="GeneID" id="56597699"/>
    <dbReference type="KEGG" id="bps:BPSS1449"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4779"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CRIADVA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013570">
        <property type="entry name" value="Tscrpt_reg_YsiA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08359">
        <property type="entry name" value="TetR_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="254" mass="28032" checksum="561152EE725E31C0" modified="2004-10-25" version="1">MTATQKADRADAPRAPAGRKSQQRVQDILRAGREVFAEKGYEHATAAEIAQRVGVSEATVFSYFRGKRELCARVIADWYDEIVDAFETGMPRDGSVRQQFAFVVRTHLRLMLVNGTGLCALVLSEGRAKQHALADELTALQRRYTAPLMDVLARGQATGQVRADMPLSLLRSMVFGPIEHVLWDAILGHRKLDTETTAEQLIDLLWTGLQPPAPENAALVRFRSDVADAMRRLDQACGRAPRKAAAGRDAQKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KC1</accession>
    <name>Q63KC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111451.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1443"/>
    <dbReference type="EnsemblBacteria" id="CAH38914">
        <property type="protein sequence ID" value="CAH38914"/>
        <property type="gene ID" value="BPSS1443"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1443"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5679"/>
    <dbReference type="eggNOG" id="ENOG502Z7U7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AQFSADY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021234">
        <property type="entry name" value="DUF2827"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10933">
        <property type="entry name" value="DUF2827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="374" mass="42338" checksum="9C7708CDAF74C275" modified="2004-10-25" version="1">MPNGGKRLVVGVSLFVRGAGQSLWENGIFQNCLLLVLLLRQSPLVAEAVMVNGGTSDADPQLMLGEWNVPLVSMDEAMTRCDVLIEMSAQFNAGWLAEYQRRGGKVVTMRVGNDYVIDIERAIFDKPSGFLFSGARYDGVWTIPEFEHSCGHYLESGLRSPVTIVPHIWHPLLFDKARATLGPGLEFGYKPGRPRWRVTMFEPNICMVKTSIVPMLVAEEAYRAQPDFVEFVRVCNTLHMKEHTTFVHFARSLDIVDHGLTTFEGRFAVYEFMAAYGDAVVSHTWENAQNYLYYELLYGDYPLVHNSPYLGRAGYFYPDFDCQEGGRQLLKAFREHDANLDAYREQSRHVLDSVSIYNAQNVAAYTEAIAALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KD4</accession>
    <name>Q63KD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative glycine betaine/L-proline transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSS1426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111438.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1426"/>
    <dbReference type="EnsemblBacteria" id="CAH38901">
        <property type="protein sequence ID" value="CAH38901"/>
        <property type="gene ID" value="BPSS1426"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1426"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4751"/>
    <dbReference type="eggNOG" id="COG4175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQIFVVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="329"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH38901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="389" mass="42275" checksum="7316723F8F4449C3" modified="2004-10-25" version="1">MDAPKVVVEGLCKVFGSNPRQALDMLAAGATKDEVFARTGQVVGVHNVSFDVREGEIFVLMGLSGSGKSTLIRLVNRLVEPSAGKVMIDGRDVAAVRRAELTALRRTDMSMVFQSFALMPQRTVLSNAAFGLEVAGMGRKDRERRAMDVLEQVGLAQFAHKLPAELSGGMQQRVGLARALAVNPSLMIMDEAFSALDPLKRKEMQNVLLQLQKEQRRTIMFVSHDLEEALRIGSRIAIMEGGRLVQVGTPQEIIANPADDYVRAFFEGIDTSRYLTAGDLMLTGAVPTLSKLDAKHVAASLNGSAEYAFVLDEARKIRGFVTRDALNGATPNVRQVESIPRDASLDHVVERCVAHPHALPVVDDDGCYCGSVDRAVLLKAITRSRGSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KE4</accession>
    <name>Q63KE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111428.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1416"/>
    <dbReference type="EnsemblBacteria" id="CAH38891">
        <property type="protein sequence ID" value="CAH38891"/>
        <property type="gene ID" value="BPSS1416"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1416"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5649"/>
    <dbReference type="eggNOG" id="COG3395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CSVMTNK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="9">
        <location>
            <begin position="269"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH38891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="467" mass="47725" checksum="C836B2BAE91E8DDE" modified="2004-10-25" version="1">MPASMSTDQALRPLLGCIADDFTGATDLANMLVKSGMRTVQTIGVPAAGAAVPADAIVVALKSRTIPAADAVAQSLAALDWLRAQGCRQFFFKYCSTFDSTDAGNIGPVADALLDALGGERAFTIACPAFPENGRTVYRGHLFVGDALLGESGMENHPLTPMKDANLVRVLQRQTPSKVGLIRHDAIALGTCAVRETIDTLRREGVRIAIADALTDRDLYVLGEACADLPLITGGSGVALGLPSNFRLGGLLPERGDAAALPAIGGASAVLAGSASKATHAQVAAWRAERPALRIDPFAAARGEPVVDQALAFARAHLPQPVLIYASAAPDEVKQVQQALGIEAAGHLVEATLAAIARGLREMGVRKFVVAGGETSGAVVQALGVKALRIGAQIDPGVPATATTEGSPCGTTEGSPCGTTEGSPCGATEGSPRGTPDAQPLGLALKSGNFGSVDFFEKALRALEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KG0</accession>
    <name>Q63KG0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secretion apparatus protein BsaZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sctU</name>
        <name evidence="13" type="ordered locus">BPSS1400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the bsa type III secretion system, is involved in the intracellular replication of invading bacteria inside the host cell. Probably necessary for the lysis of the vacuole membrane and escape into the host cell cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551828.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111412.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1400"/>
    <dbReference type="EnsemblBacteria" id="CAH38875">
        <property type="protein sequence ID" value="CAH38875"/>
        <property type="gene ID" value="BPSS1400"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1400"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4724"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYMSHIS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006307">
        <property type="entry name" value="BsaZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01404">
        <property type="entry name" value="FlhB_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="352" mass="38404" checksum="C5367C53B15C4085" modified="2004-10-25" version="1">MSDEKTEEPTDKKLRDARRDGEVSRSTDLSDAVSMSAAILLLVAAADHFGDAMRALVNGALAFVSADHSLVEMTARLYQFGGIALSAVMPLLFVAALAGIGGSVLQVGLQISLKPVMPNLGALNPAEGLKKLFSPRSAIESIKMIVKAVIVFCVAWKTIVWLFPLIAGALYQSPPELSRIFREILAKWLMVVAGLCLLMGAADVKLQRFMFMQKMKMTKDEVKRESKNDEGDPLLKGERKRLARELAAAPPQHQVAHANFVVVNPTHYAVAIRYAPDEHPLPRVVAKGLDEAAIALRRAAQDANIPIIGNPPVARALFRIGVEEPVPEELFEIVAAILRWIDAIGPRRNERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KK0</accession>
    <name>Q63KK0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS1362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188126.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111372.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1362"/>
    <dbReference type="EnsemblBacteria" id="CAH38833">
        <property type="protein sequence ID" value="CAH38833"/>
        <property type="gene ID" value="BPSS1362"/>
    </dbReference>
    <dbReference type="GeneID" id="56597567"/>
    <dbReference type="KEGG" id="bps:BPSS1362"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4668"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVAGWSP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="12"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="108"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH38833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="310" mass="32926" checksum="990B8F9B22637913" modified="2004-10-25" version="1">MKPRLLVLIPLRDHAHAHIADVFDILYALTPDQRRRAIAERGAAVQAVLTNGTTGLFAEEIACLPALEFVAALGAGYENIALDDARSRGITVVNGAGTNDDCVADHAFALLLAAVRAVPKLDAACRAGVWRDALPMRPNMSGKKLGIVGLGNIGQKIARRAAGFDLEIGYHNRRPREGAAYRYFAGLDALAHWADFLVVATPGGAATHHLIDARILDALGERGFLVNVSRGSVVDTAALADALREGRVAGAGLDVYEGEPQPPRALAALDSVVLTPHVGGWSPEALERSVRQFLENAARHFAGRPVLTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KR3</accession>
    <name>Q63KR3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528611.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111308.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1299"/>
    <dbReference type="EnsemblBacteria" id="CAH38769">
        <property type="protein sequence ID" value="CAH38769"/>
        <property type="gene ID" value="BPSS1299"/>
    </dbReference>
    <dbReference type="GeneID" id="56530282"/>
    <dbReference type="KEGG" id="bps:BPSS1299"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4587"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HLYSEQV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012787">
        <property type="entry name" value="TF_PcaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02424">
        <property type="entry name" value="TF_pcaQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="334" mass="35141" checksum="323FFE4F275FCC80" modified="2004-10-25" version="1">MHNRIADGRVKFRHLQCFLAVAQFGSVQKAAHSLSITQPAVSKTIAELESILGVRLFERGRQGARPTREGQLFMPHASACVLALRQGVGLLAREGGGAAATLEIGMLPTVAASLAPAVLKTLAAEWPRAVVRITTVANAELLERLKAGAIECAIGRLSEPERMVGLSFEHLYNEPLVAVVRAGHPLAASASPAAQLARYPVVLPPYGTMIRQAAEQLLSACGAPPLESFVEVLSVSVARALALENDAVWFVPRYAAEFDLAAGTLTRLALPVDGADEPVGLILRTDAQPSPVARALIDAVRAIARRRLAGAGTTSGRARGARGATGKGRGRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KV6</accession>
    <name>Q63KV6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase/dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198073.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111265.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1258"/>
    <dbReference type="EnsemblBacteria" id="CAH38725">
        <property type="protein sequence ID" value="CAH38725"/>
        <property type="gene ID" value="BPSS1258"/>
    </dbReference>
    <dbReference type="GeneID" id="56597478"/>
    <dbReference type="KEGG" id="bps:BPSS1258"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4523"/>
    <dbReference type="eggNOG" id="COG2130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GKDKCDY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="345" mass="36320" checksum="324AF8366945D1B1" modified="2004-10-25" version="1">MPQTKTTNRRIVLHSRPKGAPTPENFRTETAAVPVPAPGEVLLRTIWLSLDPYMRGRMSDAPSYAAPVELGGVMVGGTVSRVVSSSVPAFRDGDLVLSNAGWQDYAVSDGTDLMPLADVAHPSYALGVLGMPGFTAYFGLLHIGEPKAGETVAVAAASGAVGAVVGQIAKLKGCRVVGIAGGADKCRYVAGTLGFDACVDHHDPDFAKQLAAACPDGIDVYFENVGGAVFDAVLPLLNDHARVPVCGLIAHYNDSELPGGPNRLPLLTSSVLRKRIRMQGFIILDHYADVYPAFLKDMSEWVAQGKVKPREDVVDGLDAAPRALIGLLGGKNFGKVVVRVGPDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KW3</accession>
    <name>Q63KW3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetylpolyamine aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528554.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111258.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1250"/>
    <dbReference type="EnsemblBacteria" id="CAH38717">
        <property type="protein sequence ID" value="CAH38717"/>
        <property type="gene ID" value="BPSS1250"/>
    </dbReference>
    <dbReference type="GeneID" id="56530332"/>
    <dbReference type="KEGG" id="bps:BPSS1250"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4512"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HGNGTQG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="47"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="37331" checksum="84589856BCACA492" modified="2004-10-25" version="1">MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAAVHSEPYLRFLADAHREWRRIPEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGEHTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACRDAAGGFCYLNNAAIAAQALRARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGFNVNLPMPHGSPEAVFFAQLERARSRVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGRLGALVGGLRVPTLIVQEGGYHLETLERNAAALFRGYEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L42</accession>
    <name>Q63L42_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport/efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS1166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004539169.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111179.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1166"/>
    <dbReference type="EnsemblBacteria" id="CAH38634">
        <property type="protein sequence ID" value="CAH38634"/>
        <property type="gene ID" value="BPSS1166"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1166"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4397"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AGSCYVV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="416" mass="43171" checksum="391AFD696D9FF382" modified="2004-10-25" version="1">MSETSKRHPSLVLILIPVVMLGQLSMDMYLPALDSLRASMRATGSELQLTLSAFVVSLGVSQFLVGEFARRAGRGRAIRIALVGFVGATAGCAITSSIAFFIVCRAVQGISAAVCVALSYAVIADNAKDSHESMRGMTMLTVASTVAPLIAPVAGSQVLQLAGSWRAVFVLLLCVASAATLAFFTQPAARFDARASDASKPARQIYLGIARSSRFWRYALLCSIGTTINFCFFSFLPGILLVQNGLTQNAFSAAFFLCGLTEIAGSLLAPRISKRIGHPALTGLACACCALGGFGVAYLSTMQGAVVPIVVAFSIVELGTGMLIAPCFSAALYLFRSASNEASAICGFQQFMIAAGVATFAAAMQWQSSYALGILIGVAALLGAALACTPAGGAAADERADERADERVARAAANPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63L49</accession>
    <name>Q63L49_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative respiratory nitrate reductase subunit</fullName>
            <ecNumber evidence="12">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">narG</name>
        <name evidence="12" type="ordered locus">BPSS1159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="12"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205550.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111172.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1159"/>
    <dbReference type="EnsemblBacteria" id="CAH38627">
        <property type="protein sequence ID" value="CAH38627"/>
        <property type="gene ID" value="BPSS1159"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1159"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4384"/>
    <dbReference type="eggNOG" id="COG5013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFIHPFN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028189">
        <property type="entry name" value="Nitr_red_alph_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044906">
        <property type="entry name" value="Nitr_red_alph_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14710">
        <property type="entry name" value="Nitr_red_alph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH38627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1267" mass="141094" checksum="70A89480A3BC8912" modified="2004-10-25" version="1">MSHFLDRLRFFTTTRPQFSDGHGAVTDEDRKWEEGYRQRWQHDKIVRSTHGVNCTGSCSWKVYVKGGIVTWETQQTDYPRTRPDMPNHEPRGCSRGASYSWYLYSANRLKYPLVRSALVRLWRERRRTMAPVDAWRSIVDDEHARRGYQSRRGLGGFVRATWDEVDEIVAAANVHTVARHGPDRVVGFSPIPAMSMVSYAAGSRYLSLIGGVCLSFYDWYCDLPPASPQTWGEQTDVPESADWYNSTFIMMWGSNVPQTRTPDAHFLVEARYRGTKIVSVFPDYSEGAKFGDLWLHPKQGTDAALALAMGHVILKEFHVDGASDYFSDYCRRYTDMPCIVRLVPHGAGYVPERLVRASDFDGALGEAEHPEWKTVMIDDATGEFVVPVGSIGFRWAQPGGGDRGKWNLKEQTSRGAALAPRLSLASAHDEVVDVLFPYFGNQPHAHFAPTPHAGELSRRIGARRVTTPGGEMLVATVYDLFVANYGIDQGLGGRDVATSYDDDVPYTPAWQEAITGVKREDAISVARQFAQNAHKTQGKSMVIVGAGINHWFHMDMTYRAIINMLIMCGCVGKSGGGWSHYVGQEKLRPQTGWTALAFALDWHRPPRQMNATSFFYAHTDQWRYDPMDPAALLSPLADKSRFHGAPIDYNVRAERMGWLPCAPQLAANPLRVGADIADPAHAGAEIARRLASGELKMACEDPDAPENFPRNLFVWRSNLLGSSGKGHEYFLKHLLGTAHGVQGDEIREGGGVRRPEEVTWHADAPRGKLDLLVTLDFRMSTTCMYSDVVLPTATWYEKDDMNTSDMHPFIHPLSAAVDPAWQSKSDWEIFKGIAKRFSELAEGHLGIERDVVLAPIAHDSAAELAQPFDVRDWKRGECDAVPGRTMPAVTVVDRDYPSTYRKYTSLGPLMERLGNGGKGIGWDAKDEVALLGALNYRVTEAGCAQGRPRIDSALDAAEVILALAPETNGAVAVKAWQALSAITGLEHAHLARAREDEKIRFRDLQAQPRKIISSPTWSGIESEHVSYNAGYVNVHELVPWRTLSGRQQLYQDHPWMRAFGEALCAYKPPIDTGSYAHMVGQRSNGHPEIVLNFITPHQKWGIHSTYTDNLLMLTLSRGGPIVWISERDAQAIGVVDNDWIECYNANGALCARAVVSQRVPRGMVMMYHAQEKIVNTPGSEITGTRGGIHNSVTRVSLKPTHMIGGYAQLSYGFNYYGTVGSNRDEFLIVRKMKRIDWLDGENESARAPSVSTSGADDERHADAGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LJ2</accession>
    <name>Q63LJ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205504.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111029.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1023"/>
    <dbReference type="EnsemblBacteria" id="CAH38484">
        <property type="protein sequence ID" value="CAH38484"/>
        <property type="gene ID" value="BPSS1023"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1023"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4206"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAHYRAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="274" mass="29158" checksum="0B4D43DF7C809634" modified="2004-10-25" version="1">MSDDPDLCVAPESDEPGLLALSAFVDGELPDAQSRAMARRLASDPRAAGIAAHYRAQRAALRALFADPVAPRHGPCVAWPVRTPWWRRAAFAGGALAAGVALGWLGGALAPRFAPSAALQWVAPAAAQRAFARDADLAYALYAPDARHPVEIAAGRDGAPLAWLSARVGRRIAAPSLREYGFALLGARLLPGAGGPAAQFMYENAAGERLALYVSASAQREAAVRPWRDGGRHTFYWVSERTAYALSGQFDEGRLRTIAADVCGELGGHPQRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LJ7</accession>
    <name>Q63LJ7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111024.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1018"/>
    <dbReference type="MEROPS" id="G05.A04"/>
    <dbReference type="EnsemblBacteria" id="CAH38479">
        <property type="protein sequence ID" value="CAH38479"/>
        <property type="gene ID" value="BPSS1018"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1018"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5146"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IYGLAWM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="302" mass="31882" checksum="5AEEA4BCAC99FDFA" modified="2004-10-25" version="1">MRPFIRSFVVLFMSGNTFWLAAPWAALFVAALAAVWFPKLRAASVGLGALGYAGAFASGLIAPVALAPIALLAAAAYAVAPRRHAAVRVAGHAVFVALALALMLHWLPGFHNPRVIGPVRFTPDAAPFTMYLNLDKPLVGFWLLWVLPWLRPIDDRARAWRAGIVAAAATSAVCLVFALGVGLVGWAPKWPESAWLWLANNLLFVCFAEEALFRGYLQGGLSRLLANRVPAAGTVALVAAALLFGAAHAAGGWQWVALATVAGVGYGLAYRAGGLQAAVLAHVGLNLAHFGLFTYPMLAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LL6</accession>
    <name>Q63LL6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198264.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111005.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0999"/>
    <dbReference type="EnsemblBacteria" id="CAH38460">
        <property type="protein sequence ID" value="CAH38460"/>
        <property type="gene ID" value="BPSS0999"/>
    </dbReference>
    <dbReference type="GeneID" id="56597367"/>
    <dbReference type="KEGG" id="bps:BPSS0999"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7323"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MSKERIF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="79" mass="8848" checksum="6E4C4C31E973D500" modified="2004-10-25" version="1">MDLQQVFDIIVRHTKEVIPGLDRHAFRTTDALKDLGANSLDRSEIVIMTLESLSLRIPLVEFAGARNIGELAEVLYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M02</accession>
    <name>Q63M02_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543544.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110869.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0857"/>
    <dbReference type="EnsemblBacteria" id="CAH38320">
        <property type="protein sequence ID" value="CAH38320"/>
        <property type="gene ID" value="BPSS0857"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0857"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4955"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RADDTHY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026002">
        <property type="entry name" value="ATC_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14196">
        <property type="entry name" value="ATC_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="427" mass="44875" checksum="A5322D6502F0E113" modified="2004-10-25" version="1">MRACAGSGARRAYLAQVPRAACVSYVLMRAMHAIRGAAERADSTDAARLPAVLHTLKRQGVTGAIAFGGEGNLRDPAFTIYRAGGRTWAVVGVLGGVGGVGASGNAAACVAAGVSGLSGGKAARLARFRESRERIERRIEMATSPGGRPMTTIPIHPAAGGAAHDEPLGILARRRIEAEIIKPIYEIMKREFGLERAQAVIAEAVRGAALDAGRAFAAKEPGGTSIASFVALQVLWEKDDALDVDVHRADDAHYDYDVRRCAYAQMYREMGLAEIGHLLSCARDSVFIEGYDARIALTRTRTLMQGGTHCDFRYRLAQPPRDGAADATHAAPGGLAGGMREARVRENEPAGQPEPAPGDRAGPSPESPPRSRAESRTETGTEPGTASQASGDAPGIRRASSPTFDRRAVAASPAGEHTRPEAGDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M51</accession>
    <name>Q63M51_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004528088.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110820.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38271">
        <property type="protein sequence ID" value="CAH38271"/>
        <property type="gene ID" value="BPSS0810"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0810"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7077"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="INHIGWP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="22728" checksum="74F3C10EE5C0AC3D" modified="2004-10-25" version="1">MQQQVDGGADSLAPVIETARLILSGPRLEDFDGSRALWADPDVTRLIRDEPFTSEECWLRLLRYVGHWRLLGFGYWMAREKDTGRFIGEVGFADAKRDIVPPLDDAPELGGALAPAAWGQGIAREALHAVLEWADANLTARRTVCLIGPKNRFSMRLAAEFGYREVAVAEYKGEPIRVFERPAAGPRAGETRPPADAADAAERGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M70</accession>
    <name>Q63M70_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004536803.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110801.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0792"/>
    <dbReference type="EnsemblBacteria" id="CAH38252">
        <property type="protein sequence ID" value="CAH38252"/>
        <property type="gene ID" value="BPSS0792"/>
    </dbReference>
    <dbReference type="GeneID" id="56530756"/>
    <dbReference type="KEGG" id="bps:BPSS0792"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7045"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EILVGWQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="247" mass="25885" checksum="93280989B3D3BA17" modified="2004-10-25" version="1">MEARLAGKTALVTAAAQGIGRASAERLAREGARVIATDIRIDALRDGPFDARVLDVRDGAAIDALADAIGPVDVLFNCAGFVHAGSVLDATEDEWDFGFDLNVKSMYRTIRAFLPAMLARERGSIINMASAASSVKGVPNRFVYGATKAAVIGLTKAVAADFVTHGIRCNAICPGTVESPSLDARIAEQACARGEPIDAVRAAFVARQPMARIGRPQEIAALVAYLASDEASFTTGAIHLIDGGWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MA2</accession>
    <name>Q63MA2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939741.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110769.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0758"/>
    <dbReference type="EnsemblBacteria" id="CAH38218">
        <property type="protein sequence ID" value="CAH38218"/>
        <property type="gene ID" value="BPSS0758"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0758"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6998"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MPPTDQD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="154" mass="17134" checksum="7C1AAEBCC08A6324" modified="2004-10-25" version="1">MHAVSRRPSLSSAVFYRDPRAALEWLERAFGFARGIVVSDAQGRIAHAELSFGDGVVMIGAAGWSEFAFSPESLDGKNTQCVHVQLESDLDAHCERARAAGAVILQEPADQFYGDRTYRARDPERHVWTFARTVRRVSREEAERHGGFSIEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MC4</accession>
    <name>Q63MC4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004556091.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110747.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0736"/>
    <dbReference type="EnsemblBacteria" id="CAH38195">
        <property type="protein sequence ID" value="CAH38195"/>
        <property type="gene ID" value="BPSS0736"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0736"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6964"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WVEGTAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="441" mass="46795" checksum="EB84FD56CA343821" modified="2004-10-25" version="1">MPMRFHLVRRLGRAASFAIGPMASLLFVAHGAAGAEPPRAALLAAGCKTLAERVHAPPGSGPVFLGSYEPAPGGAALAGALTQAAFVYDNALASIALIACHRPGDARRIADAILQASRQDRHYRDARVRNAYRAGALPPGPAPLPGWWDTPSKRWFEDAYQAGTATGNVAWAALSLLAVYEATRERRYLDGAAALMGWVDPGRLDATAPAGYVGGEFGHEPQPLRQGWKSTEHNVDAYAVFRWLAARTGDARWHAAAGRARRFVSAMWEPGDGRFLIGTRDDGHTPNTGPSALDASLWPLLAMPDAPADWRRSLAWVERAHRIDGGYGFNAHPDGVWTEGTAQAALALQAAGRSDDARPLWALLMSQRAPSGLLFATPEPSIRTGLSIGPTSKTDDFRYFHLPHLGATAWAVLAAAGWNPFRPGGCLAAGYPGDAAPACGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ3</accession>
    <name>Q63MJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009967967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110678.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38121">
        <property type="protein sequence ID" value="CAH38121"/>
        <property type="gene ID" value="BPSS0663"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0663"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024973">
        <property type="entry name" value="ESPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13018">
        <property type="entry name" value="ESPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESPR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="131" mass="13272" checksum="589120A5538F4382" modified="2004-10-25" version="1">MNKPYRTIWNASLGAWVAASVIARTCGRPGSTRTILVVTVAMVGASGAYAQYVAGGGSQTEQPGGKRDISTSANDSALLSNARGGDSGANGSSARGNGTADENGRAYIGMSTFLGQKTMAADMQGPFHGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MM3</accession>
    <name>Q63MM3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004545887.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110648.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0627"/>
    <dbReference type="EnsemblBacteria" id="CAH38084">
        <property type="protein sequence ID" value="CAH38084"/>
        <property type="gene ID" value="BPSS0627"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0627"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6813"/>
    <dbReference type="eggNOG" id="COG3719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVRMRCQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01062">
        <property type="entry name" value="RNase_T2_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039378">
        <property type="entry name" value="RNase_T2_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="PTHR11240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="SSF55895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266593" evidence="3">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="25604" checksum="B16FE76DF7086811" modified="2004-10-25" version="1">MLRTFARAACALAVASACNNASAYDYLLLATSWEPGFCATHSATECGTLSGSYASTNLSLHGLWPNNYDGNQPFYCGVPQNEIDLDTTHQWCSMDAYPVSSSTLATLSTYMPGVASCLDKHEWYKHGTCAQAPSADAYWNNATGMVSRLSTTSFNTFLQSNAGNTVTRTQLLNAFEGAFGSNTRGAVSLKCVKVNYVSYFTEAWISVKTDATSQFPSAASLVTDAGTQGTCPTSGIFIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N42</accession>
    <name>Q63N42_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative copper resistance-related lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529972.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110477.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0455"/>
    <dbReference type="EnsemblBacteria" id="CAH37911">
        <property type="protein sequence ID" value="CAH37911"/>
        <property type="gene ID" value="BPSS0455"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0455"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6602"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ADAWQST"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267003" evidence="3">
        <location>
            <begin position="21"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="554" mass="58395" checksum="C54A5985A86A8ACB" modified="2004-10-25" version="1">MTARFVSLRIGAAAAVLAFAAGCTTFSRDGGFGAVSSAAAERLGQDAVLVKTDADRDAVARRTQALLSKPLGIDDAVQIALLNNRGLQASYAELGLSEADLVQAGRLPNPGFTFSRTHSSNDLSIGRTFSMSVLSMLTLPLATKIEGRRFEQTKLETADAMLKVAADTRRAYVEAVAAAQAATYAEQVKDSADAGAELALRMRRAGNFSRLDYAREQAFYADAVAQLANARLRAVAAREKLTRAMGLWGASAGYELPERLPELPAERPRLDDVERFAMDHRLDIRAAKLRTQGVASSLGLTQATRFVNALELGYLDNYETDKGHEHGYEISVEIPLFDWGGAKVARAKAAYLQSANRLAQTAIDARSEVRESYAAYVTRYDIAKHYRDEVVPLRKTISDEMLLRYNGMLVSVFELLADARDQIGAVNAYIDALKDYWLAQADLQQAVGGRLPRGAQAASEPPAATPASAAAAGARAAAVASGAAAPASEATSVSSSASVSTSASASMPATTPASTAASAPALASPRAIATAVSSHAHEPASLSGAVPLTNSKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N44</accession>
    <name>Q63N44_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530768.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110475.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0453"/>
    <dbReference type="EnsemblBacteria" id="CAH37909">
        <property type="protein sequence ID" value="CAH37909"/>
        <property type="gene ID" value="BPSS0453"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0453"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6600"/>
    <dbReference type="eggNOG" id="ENOG5033C78">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ENGHGMH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266463" evidence="1">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="135" mass="14025" checksum="3B448ADF8A178DAC" modified="2004-10-25" version="1">MSYWRKLFVIVLLVLSLPVQTLAAVSMNCDPAPADDGGAPAHAWLQASAENGHGMHDAAAADDGHRHDGRGGAHHDHAHACPTCLSCCVGAGLPAASVAAASFDAARPRLFLPRDTRAVSFLTGGIERPPRTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NB1</accession>
    <name>Q63NB1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552316.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110408.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37836">
        <property type="protein sequence ID" value="CAH37836"/>
        <property type="gene ID" value="BPSS0385"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0385"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6513"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QWIIFPA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="301"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="807" mass="91307" checksum="E7B41B95E849CAE4" modified="2004-10-25" version="1">MNASPSVDSIDVAFEALQRLLKELPAFESTLNSEADVRLKIVDTMLSDVLGWTKAEMQTEESAGTGFLDYKLSVNGIARVVVEAKRAERVFDLGGRECGFPYKLSGPALKNIDLVEGIRQAIQYSAYKGTELACVTNGHEWLVFRSNRHGDGTDTLEGKAFAFGSLECVRDQFKNFFNLLAKVRVASLAFRGLFQEAEGRVIRHSGFRRVLRPPETAAFLPQPEIIPELDRLMTSFFQRLANERDREMIDYCFVETKESKVAEGRLLRLAEDLVGHVRALNTQSGQQLTELLTRARTASLNQFILIVGTKGAGKSTFINRFFNTKLNQELRDACVPIIVNLSDSDGDHKTVVEWLRRNLLAKAEAAISDKAPTWDELIGHMFFSEYQRWSTATMANLYGRDKEAFKVEFGKHIEGIRRDNPLEYIHGLLRNFVKGRKQLPCLVFDNADHFSIEFQEHVFQFARSLFEQELCVVIMPITDKTSWHLSRQGALHSFENEALLLPTPPAKQVLEKRINFVLKKIEDADVHGRGTYFIGKGIRVDVSDLLKFVCGLQEIFLNTDKTTYVLGQLANHNVRDVLQLSRDVVNSPHIGLDETFKAYVLKSAIHIPEYKTRRALIRGRYDIFVPSSNQYVRNIFALNTELETTPLLGIRMLQTLSDAVVHSGDTQSRYMAKDDLYAYLLAMGIERRAISLWLDALLKTVLVINYDPTCTDESAATQLEISPAGEQHLFWGTGNYDYVEAMAEVTPVLDGAAFTDMETASRGYGAQRSMELRKAFVAYLTGEDKFFCQVPDHESYRGQRNPIHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NE1</accession>
    <name>Q63NE1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198127.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110378.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0358"/>
    <dbReference type="EnsemblBacteria" id="CAH37806">
        <property type="protein sequence ID" value="CAH37806"/>
        <property type="gene ID" value="BPSS0358"/>
    </dbReference>
    <dbReference type="GeneID" id="56597208"/>
    <dbReference type="KEGG" id="bps:BPSS0358"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6481"/>
    <dbReference type="eggNOG" id="COG4454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PFFGEFH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267009" evidence="2">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="109" mass="11768" checksum="9A20260DE881E639" modified="2004-10-25" version="1">MTFPRAYAFAAAILVAGAAHAADLPTFRLEMADGKLNPARIEVPAGQRIKIQIRNTGKGAVEFESVQLRKEKVLAPGGESFVVIAPLSPGEYKFFDDFHQQAQGVIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NL0</accession>
    <name>Q63NL0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533818.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110309.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0289"/>
    <dbReference type="EnsemblBacteria" id="CAH37737">
        <property type="protein sequence ID" value="CAH37737"/>
        <property type="gene ID" value="BPSS0289"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0289"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6392"/>
    <dbReference type="eggNOG" id="ENOG50316X1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KANSYPQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025421">
        <property type="entry name" value="DUF4148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13663">
        <property type="entry name" value="DUF4148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267012" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="9829" checksum="40FDDE60C7534B31" modified="2004-10-25" version="1">MKRSSLLAFAAIALAVAAPAFADGGIGPAGGYGDASGHSHGARTRAEVRAELEQAQRDGTLAALRKSMSYAPPGAELGAPRPYRPDPDTNQLAGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NT4</accession>
    <name>Q63NT4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tar</name>
        <name evidence="10" type="ordered locus">BPSS0215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205365.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110235.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0215"/>
    <dbReference type="EnsemblBacteria" id="CAH37660">
        <property type="protein sequence ID" value="CAH37660"/>
        <property type="gene ID" value="BPSS0215"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0215"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6287"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SARMMMD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00181">
        <property type="entry name" value="Tar_Tsr_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035440">
        <property type="entry name" value="4HB_MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003122">
        <property type="entry name" value="Tar_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02203">
        <property type="entry name" value="TarH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00319">
        <property type="entry name" value="TarH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47170">
        <property type="entry name" value="SSF47170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="211"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="8">
        <location>
            <begin position="268"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="537" mass="56681" checksum="CE386DB7FE623684" modified="2004-10-25" version="1">MFSKIKLASGLLGVLVTFCLFLIAVEGLGFWSLSASRSNVDALSNVAIKQTDATTVATQHMLDARTNLSRASTRMVKGDPMPTETLQHVRDQLALADRAFAAFTAAPTISAENTERAAALTDRYRKYHAALVDLVQFLESNNMQAFLDQPTQQIQDAYLGELRTFSEFSGRTSEHALGMIDTGMHWFETVGAVLLVLMLACIAGIYAVARRAVVAPLAQALVHFERIAQGRLDETVAPHGVYEIERLLRGLADMQASVAGTVRVVRNASNAIHLGAAEIASGNADLSARTSSQAASLEQTAASMEELTATVRQNSDSARAASALADDALRTTQNGGAIVDDVIDKMHGIARSSGRIAEIIAVIDGIAFQTNILALNAAVEAARAGEEGRGFAVVAGEVRALAQRSAQSAKEIKLLIEESVAQIDGGSELVERAGEAMRSVSASIERVAQTMTEITAASVEQSAGIEQVNQAVTQMEQLTQQNAALVEEVAAAAGSLNEQTEQLQQSVSVFELGDARARRLAGGAALAGARAPQLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P92</accession>
    <name>Q63P92_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate resistance transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">chrA</name>
        <name evidence="8" type="ordered locus">BPSS0053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205325.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110077.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0053"/>
    <dbReference type="EnsemblBacteria" id="CAH37496">
        <property type="protein sequence ID" value="CAH37496"/>
        <property type="gene ID" value="BPSS0053"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0053"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6057"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="CMFFGCL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="41710" checksum="74BF849A3FEEAB81" modified="2004-10-25" version="1">MTTTVTPHAPAYSMSQLIRYMLRLGTFGFGGPVALAGYMRRDLVERRGWISEADYKEGLTLAQLAPGPMAAQLAIYLGYVHYRILGATLAGFAFVLPSFLMVVALGFAYAHFGGLPWMQAVFYGVGAAVVGIIAMSAYKLTTKTVGKDKLLGAIFVTLAAVTFVTESEIAWLFIAAGLIGWLWRAPPKWLGSSGANALAAAHLPATGGFVSGLMRGVDVSVLAQIGLFFAKAGAFVFGSGLAIVPFLYGGVVTEHHWLNDKQFVDAVAVAMITPGPVVITVGFIGYLVAGFPGALVAALGTFLPCYLFTVVPAPYVKKYGHLPSVKAFVDGITAAAVGAITGSVLVIAKRSIVDAPTAAVALVTIVLLWRFKKLQEPVIVAAAAVVGLLAYPWLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PB4</accession>
    <name>Q63PB4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative anaerobic growth regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529578.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110055.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0031"/>
    <dbReference type="EnsemblBacteria" id="CAH37474">
        <property type="protein sequence ID" value="CAH37474"/>
        <property type="gene ID" value="BPSS0031"/>
    </dbReference>
    <dbReference type="GeneID" id="56531523"/>
    <dbReference type="KEGG" id="bps:BPSS0031"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6030"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QMMVLGS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018335">
        <property type="entry name" value="Tscrpt_reg_HTH_Crp-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00042">
        <property type="entry name" value="HTH_CRP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="5">
        <location>
            <begin position="173"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="251" mass="27631" checksum="BDCABDAFBB4822ED" modified="2004-10-25" version="1">MLTPVARPAAAAAPVHASSTWAPRQAAHCSTCAMRHLCMPQGLAPEALARLESVICTARPVRRGETLFREGDTFDNLYAVRSGSLKTIATRHDGREQVTGLHLAGEALGLDGICDDAHPRTAVALEDSSVCVIPYSALKTLCSEAGTMQLRMHKLMSEQIVRETSQTMVLGSLNAEERVAAFLLDVSSRYMKRGYSPNEFNLRMTREDIGSYLGMTLETVSRTLSKFHKRGLIEMQGRMVRIVDFDGLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PJ1</accession>
    <name>Q63PJ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004195844.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109978.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3386"/>
    <dbReference type="EnsemblBacteria" id="CAH37397">
        <property type="protein sequence ID" value="CAH37397"/>
        <property type="gene ID" value="BPSL3386"/>
    </dbReference>
    <dbReference type="GeneID" id="56593883"/>
    <dbReference type="KEGG" id="bps:BPSL3386"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1808"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VEFDGTW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="179"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="288"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="546" mass="59119" checksum="4C0B6EA284773011" modified="2004-10-25" version="1">MAWSTHEVSNQFDELTDYNLFATDPALGEALERAGASWAAPRLDAFGARLGTRDIARLAEDANRHVPELNAFDRRGRRIDRVDFHPSWHALLGLYREQGLISLAFRESRAGRWAANAAGFYLHGQIEAGTLCPATMTQASIPVLQKEPALWAQLKDKLYSDTHDPRDAPIGAKQSIMIGMGMTEKQGGSDVRANTTLAVPVGAGGRGGEHLLRGHKWFFSAPMCDAHLVVARTEAGGPSCFYVPRWRPDGTKNAVRIQRLKNKVGNRSNSSSEIELDDAWGVMLGEEGRGIPTIIEMAAYTRLNCVLGSAAILRQGLVQAIAYTRQRHAFGRALAEQPLMRAVLADLALESEAALALAMRLAQAFERGEPAWTRIVAPAAKFWVCKRAVEAAGEVMEIFGGNGYVDDGPIARLFREAPVNSIWEGSGNVMCLDVMRAISREPDAAHALIDELHALGGRDARIRAELDALRAQLGTPPDALEALGRVLAQRIALLAQACLLSDAAPAVVSDGFIATRFGEPAWGRVTGALDARRVDAAALLQRAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PP1</accession>
    <name>Q63PP1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL3332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551065.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109928.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3332"/>
    <dbReference type="EnsemblBacteria" id="CAH37345">
        <property type="protein sequence ID" value="CAH37345"/>
        <property type="gene ID" value="BPSL3332"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3332"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1881"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GQRSAIW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="207" mass="21587" checksum="8C028A2FDC45C2AB" modified="2004-10-25" version="1">MSVETWLAFAGASIVLLMIPGPTILLVIGDSLANRHRSSWSTVAGVAAGDTTAMTISLAGAGALLAMSAAAFTALKLVGGGYLVYLGIRSILHARRIGAMDVRIERRSAKRRFLSAWAVTALNPKSIVFFVAFVPQFISPHDTFARQCAILLPTFVCLAAINAACYARIARFAAARLTGAAAQRRFGYGGGAALIGAGALTLGMSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PT5</accession>
    <name>Q63PT5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938904.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109883.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3287"/>
    <dbReference type="EnsemblBacteria" id="CAH37300">
        <property type="protein sequence ID" value="CAH37300"/>
        <property type="gene ID" value="BPSL3287"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3287"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1931"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLTIWFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="496" mass="52285" checksum="C7F7F955AA460CAE" modified="2004-10-25" version="1">MTVLSDYLCHDAIGLAQLVAQREVSARELLDAAIGRAQALNPAINAIVLNDYAAARERAASGTLAGPLAGVPYLVKDLGSAVAGLPLSLGSRHYRHHVPAEDSPLIVRTKAAGLNIFGKTNTPELGQMPYTESALLGVCRNPWNLDHTPGGSSGGAAAAVAAGIVPLAHASDGGGSIRIPASCCGLFGFKPSRDPALTPWPVPGEIVVEHAVSRSVRDSALLLDITTGRTAPGTLEGVGAPGTYLGALDAPPPALKIGYVTDPMLAPALSADVRDALDRAAALAASLGHNVEPAALNLDFAQIGEVFLTIWAAIADELVLGAERITGRKPARAEFEPATWAMAQVGRRLVRERLPHALELQRQITARVAGLVSRYDVLLCATLAAPPIKIGEMQPTPLETRQMELLGVLPIKPLLKRMLAEVSHQAFAWAGCTELFNLTGQPAMSVPLHWSARGLPVGVQFVARHGDDARLFALARQLELAQPWFDKRPPLARVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PV0</accession>
    <name>Q63PV0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524381.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109868.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3272"/>
    <dbReference type="EnsemblBacteria" id="CAH37285">
        <property type="protein sequence ID" value="CAH37285"/>
        <property type="gene ID" value="BPSL3272"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3272"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1951"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RVKKVHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="266" mass="27035" checksum="E92925F7D14611C6" modified="2004-10-25" version="1">MSNSRVRQTLVRTTLVIGLSAGLAATLQGCVLAVAGAAAGGGALVATDRRTLGAQTEDREIQVKALTQMNNGLPDGSHVNVTVFNRRVLLTGEVPSDAAKQRAEEIVRAINNVNSIVNELAVGPASSLSDRANDSYLEGRVKTAMIAEKGISANNYKVVCERGNVYLMGLVTTDEGSRGADVASRVPGVEKVVKVFQYIKPQDAQALTAATPASGASAAAAPATAPEGATVGAVPDSSVTATPLSAPAPVSNSSNVHPGNPKAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PX4</accession>
    <name>Q63PX4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL3250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525667.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109844.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3250"/>
    <dbReference type="EnsemblBacteria" id="CAH37261">
        <property type="protein sequence ID" value="CAH37261"/>
        <property type="gene ID" value="BPSL3250"/>
    </dbReference>
    <dbReference type="GeneID" id="56527897"/>
    <dbReference type="KEGG" id="bps:BPSL3250"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1983"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FPWVLSQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="312" mass="33170" checksum="341FDFB10CF16509" modified="2004-10-25" version="1">MNTRDLQAFVAVVDSGSMVAAATRLHLTQPGLTRRVQNLETTLGVPLLDRQSKPLKPTAAGREVYALARNVLRSVDELLAVAAPGSEPAGELRIGVPPFLSELALEGPIDRLRDAFPRLTLRITAGWSPALLENVERAVLDAAAVMMPASFPMPETLVSTLLGVQPTVLVAARDFALPPGPLSLDALARYPWVLSQDGCGMRSALSRAFSAAGLPFDVAVEAFGSDLQLSLVARGAGLGIASASALARSPHRNALRIVETADVEPGINVWLVHGVLPGRLMRPVELLRERLAAVLEEERSRRLGGEADMPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Q76</accession>
    <name>Q63Q76_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL3149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199929.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109742.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3149"/>
    <dbReference type="EnsemblBacteria" id="CAH37159">
        <property type="protein sequence ID" value="CAH37159"/>
        <property type="gene ID" value="BPSL3149"/>
    </dbReference>
    <dbReference type="GeneID" id="56594079"/>
    <dbReference type="GeneID" id="66545684"/>
    <dbReference type="KEGG" id="bps:BPSL3149"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2094"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NYLVFPK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="255" mass="27132" checksum="CA8FCB30B7A79141" modified="2004-10-25" version="1">MISAIGRFVIGGLERTGYATRMFVRVVLEFFSLLRRPRLVTKQIHFLGNYSFVIIAVSGLFVGFVLGLQGYYTLNRYGSEQALGLLVALSLVRELGPVVSALLFAGRAGTSLTAEIGLMKAGEQLTALEMMAVDPLKNVIAPRMWAGVIAMPLLAAIFSAVGVLGGYVVGVLLIGVDPGAFWSQMQGGVEVWADVGNGVIKSVVFGFAVTFIALFQGYEAKPTPEGVSHATTKTVVYASLAVLGLDFLLTALMFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QH1</accession>
    <name>TRPD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpD</name>
        <name type="ordered locus">BPSL3052</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004186823.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109647.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QH1"/>
    <dbReference type="SMR" id="Q63QH1"/>
    <dbReference type="STRING" id="272560.BPSL3052"/>
    <dbReference type="EnsemblBacteria" id="CAH37063">
        <property type="protein sequence ID" value="CAH37063"/>
        <property type="gene ID" value="BPSL3052"/>
    </dbReference>
    <dbReference type="GeneID" id="56597088"/>
    <dbReference type="KEGG" id="bps:BPSL3052"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2213"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000227142" description="Anthranilate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <sequence length="343" mass="37017" checksum="7391E60399DB43C9" modified="2004-10-25" version="1">MTITPQEALQRTIEHREIFHDEMLHLMRLIMRGDMSPVMAAAIITGLRVKKETIGEIAAAATVMREFARRVEVEDNANFVDIVGTGGDGSHTFNISTATMFVAAAAGAKVAKHGNRGVSSKSGSADVLEALGVNIDLQPEQVAASIAETGMGFMFAPNHHPAMRNIAPVRRELGVRTIFNILGPLTNPADAPNQLMGVFHPDLVGIQVRVMQRLGAQHVLVVYGKDGMDEVSLGAATLVGELRDGEVREYEIHPEDFGMQMVSNRTLKVESADESRVMLLEALGNKPGVAREIVTLNAGTALYSADVAGSIADGIQLARDAIASGRAREKVDELVRFTQQFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QH9</accession>
    <name>Q63QH9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein PaaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaI</name>
        <name evidence="2" type="ordered locus">BPSL3044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535436.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109639.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3044"/>
    <dbReference type="EnsemblBacteria" id="CAH37055">
        <property type="protein sequence ID" value="CAH37055"/>
        <property type="gene ID" value="BPSL3044"/>
    </dbReference>
    <dbReference type="GeneID" id="56528145"/>
    <dbReference type="KEGG" id="bps:BPSL3044"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2223"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FACNSHN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011973">
        <property type="entry name" value="PaaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02286">
        <property type="entry name" value="PaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="130" mass="13968" checksum="658DD1091205D835" modified="2004-10-25" version="1">MYAADACSRSLGIEVLEVRPGYARARMPVRGDFLNGHQICHGGLVFTLADSTFAFACNSYNINTVAAGCSIEFLRPVAGGDVLTAEATEQTLNGRHGIYDIRVTNRAGETVAMFRGKSTQIKGTVIPVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QK2</accession>
    <name>Q63QK2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">ftsZ</name>
        <name evidence="8" type="ordered locus">BPSL3020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194380.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109616.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3020"/>
    <dbReference type="EnsemblBacteria" id="CAH37032">
        <property type="protein sequence ID" value="CAH37032"/>
        <property type="gene ID" value="BPSL3020"/>
    </dbReference>
    <dbReference type="GeneID" id="56594279"/>
    <dbReference type="GeneID" id="66548421"/>
    <dbReference type="KEGG" id="bps:BPSL3020"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2247"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="14"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="398" mass="41600" checksum="9B48489C2FA99B99" modified="2004-10-25" version="1">MEFEMLETETNGTIIKVIGVGGAGGNAVQHMINKGVQGVDFVVMNTDAQALSRSRAPSVIQLGNTGLGAGAKPEMGRAAAEEARERIADALRGAHMVFITAGMGGGTGTGAAPVVAQIAKEMGILTVGVVSKPFEFEGGKRMRVAEAGSQQLEDHVDSLIVVLNDKLFEVMGDDAEMDKCFQCADDVLNNAVAGIAEIINVDGLVNVDFEDVKTVMGEQGKAMMGTATVAGVDRARLAAEQAVASPLLEGVDLSGARGVLVNITSSRSLRLSETREVMNTIKSYAADDATVIFGAVYDDAMGDALRVTVVATGLGRAAKKQQSAPMTLLRTGTDNQPISAAPQGYAASHHVSTGDYGAFDTPAVWRNSRETAASHVQALQEKGVDTYDIPAFLRKQAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RP4</accession>
    <name>NUSB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">BPSL2628</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185707.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109224.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63RP4"/>
    <dbReference type="SMR" id="Q63RP4"/>
    <dbReference type="STRING" id="272560.BPSL2628"/>
    <dbReference type="EnsemblBacteria" id="CAH36636">
        <property type="protein sequence ID" value="CAH36636"/>
        <property type="gene ID" value="BPSL2628"/>
    </dbReference>
    <dbReference type="GeneID" id="56594848"/>
    <dbReference type="KEGG" id="bps:BPSL2628"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2724"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000265497" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <sequence length="145" mass="15981" checksum="9C669799DAE6F855" modified="2004-10-25" version="1">MKKSARRQSRELATQGLYQWLLSNAAPGEIDAQLRGALGYDKADKTLLDTILHGVIREHATLAEAISPSLDRPIDQLSPVERAVLLIATYELTHQIETPYRVIINEAVELAKTFGGSDGYKYVNGVLDKLAVKLRPAETQARRGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S99</accession>
    <name>ACPS_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="1">Holo-ACP synthase</shortName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpS</name>
        <name type="ordered locus">BPSL2425</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191194.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109017.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63S99"/>
    <dbReference type="SMR" id="Q63S99"/>
    <dbReference type="STRING" id="272560.BPSL2425"/>
    <dbReference type="EnsemblBacteria" id="CAH36428">
        <property type="protein sequence ID" value="CAH36428"/>
        <property type="gene ID" value="BPSL2425"/>
    </dbReference>
    <dbReference type="GeneID" id="56596340"/>
    <dbReference type="KEGG" id="bps:BPSL2425"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2965"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DERHYAV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175625" description="Holo-[acyl-carrier-protein] synthase">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <sequence length="143" mass="15364" checksum="BBEECBDC1928200C" modified="2004-10-25" version="1">MAIYGIGTDLAQVSRIAAVLERTGGRFAEKVLGPDELRVFHARRARSEARGIAFLATRFSAKEAFSKAIGLGMHWPMTWRALQTLNRPSGEPYVVASGELAAWLDARGITARVTVSDERDYAVTFVVAEAPDDVAAARSGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD3</accession>
    <name>Q63SD3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108983.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2391"/>
    <dbReference type="EnsemblBacteria" id="CAH36393">
        <property type="protein sequence ID" value="CAH36393"/>
        <property type="gene ID" value="BPSL2391"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2391"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2725"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FNDAVAC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="225"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH36393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="348" mass="38711" checksum="67ED3DE3B1DAA7D3" modified="2004-10-25" version="1">MTSVNRPSSPARTIQVAIVALPPVSMSGVGPIVDALNLANEIDGRLLYRWQVCSWDGRAVPLAGGAQWHAHAAFNDAIVCDWLIVVSERFQQFADYRLFLASLARVGQRTPLVTGIHHGVWWLAMAGQLSGYRVSVNWETYQQFAEQFERSIVTQQIFEIDRDRATCAGGQASVDFMLAMIGRDQGPELAERIADALGTGPLRSGEARQRIPFVTAPGERHPRLNDALLLMEANIEDPLTTDEIAGLVGVSRRQLERLFRQYLGAMPSKYYLNLRLLKARTQLQRTSKSVVQVSLACGFSSAAHFSNAYRERFGVTPREDRRAWLEKQHGGVEPPRAGAMVERPSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SD6</accession>
    <name>Q63SD6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative arginine N-succinyltransferase, beta chain</fullName>
            <ecNumber evidence="2">2.3.1.109</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.109" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527438.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108980.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2388"/>
    <dbReference type="EnsemblBacteria" id="CAH36390">
        <property type="protein sequence ID" value="CAH36390"/>
        <property type="gene ID" value="BPSL2388"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2388"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3014"/>
    <dbReference type="eggNOG" id="COG3138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RFFSMEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008791">
        <property type="term" value="F:arginine N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007041">
        <property type="entry name" value="Arg_succinylTrfase_AstA/AruG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017650">
        <property type="entry name" value="Arginine_N-succinylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04958">
        <property type="entry name" value="AstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03243">
        <property type="entry name" value="arg_catab_AOST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03244">
        <property type="entry name" value="arg_catab_AstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="343" mass="37544" checksum="064647E1F76DD951" modified="2004-10-25" version="1">MIVVRVVQTGDVDALVALAQETGPGLTTFKPDRDALAARIERTRRTLGNDATPAEAGYFFVMEDSQTGDIAGVCGIETEVGLEQPFYNYRVSTVVHASQDLGVWTKMSLLNISHDLTGYAEVCSLFLSPRYRTGGVGGLLSRSRFMFIAQFRERFPERICAELRGHFDDDGTSPFWRAVGSHFYQIDFNAADYLSSHGRKSFLAELMPRFPVYVDLLPRDAQDVIGVTHRDTLPARKMLEAEGLRYQNHVDIFDAGPVLECHVADLRTVRESAVVPVAIGAPAARENAPRSLVSNTSLADFRVGVAPGLVDAGVFTLSAEDAAALRVSEGELVRVLPLKPKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SH8</accession>
    <name>Q63SH8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">hutU</name>
        <name evidence="13" type="ordered locus">BPSL2342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
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        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192292.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108938.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2342"/>
    <dbReference type="EnsemblBacteria" id="CAH36345">
        <property type="protein sequence ID" value="CAH36345"/>
        <property type="gene ID" value="BPSL2342"/>
    </dbReference>
    <dbReference type="GeneID" id="56596248"/>
    <dbReference type="KEGG" id="bps:BPSL2342"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3077"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
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        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="146"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="357"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="498"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH36345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="562" mass="61556" checksum="15D1800565C89474" modified="2004-10-25" version="1">MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILASLKDLNDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFAVANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDRKATTLDEALGMIEEAKRTGKPVSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWSVARWRDAQKVDPRSIVQVAKQSMAVQVRAMLTLQARGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDRKVKELIPDDAHLHNWLDMARERIAFQGLPARICWVGVNDRYRLGQAFNEMVKTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNALLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHARLGRVLFNDPATGVMRHADAGYELAQRTANEAGLKLPMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SI2</accession>
    <name>Q63SI2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HutG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2338</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2338"/>
    <dbReference type="EnsemblBacteria" id="CAH36341">
        <property type="protein sequence ID" value="CAH36341"/>
        <property type="gene ID" value="BPSL2338"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2338"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3082"/>
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    <dbReference type="OMA" id="WHIPQLY"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010247">
        <property type="entry name" value="HutG_amidohyd"/>
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        <property type="entry name" value="N-FG_amidohydro"/>
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        <property type="entry name" value="FGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02017">
        <property type="entry name" value="hutG_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="267" mass="29451" checksum="5FA32DE588350F34" modified="2004-10-25" version="1">MNTASQPPVFTLHRGTLPLLVSIPHAGTHLPDDIAATMTPVARHVDDCDWHLERLYDFAKTLGASVLVPSHARYVVDLNRPPDDANLYPGQDTTGLVPVDTFDRAPLYAHGHEPTVTEIARRRERYWAPYHGALAGELQRLKDAHGRALLWEAHSIRSHVPRFFDGRLPDFNFGTSSGASAAPGLADKLAALVDRHGGYTAIANGRFKGGYITRHYGAPEQGVQAVQLELAQVTYMDETRPYSYDETKARRIAPLLEALVSAALEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV3</accession>
    <name>Q63SV3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_tranf_2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL2218</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524768.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108813.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2218"/>
    <dbReference type="EnsemblBacteria" id="CAH36220">
        <property type="protein sequence ID" value="CAH36220"/>
        <property type="gene ID" value="BPSL2218"/>
    </dbReference>
    <dbReference type="GeneID" id="56528974"/>
    <dbReference type="KEGG" id="bps:BPSL2218"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3227"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GTHEEDV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019290">
        <property type="entry name" value="GlycosylTrfase-like_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10111">
        <property type="entry name" value="Glyco_tranf_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tranf_2_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="272" mass="30633" checksum="D70D35FB685C8777" modified="2004-10-25" version="1">MLSIIVTWRNRNELAGALPGLVETAGRLNGEVVIVNFGGDAASLARQLEGFEHAVQVAQWREQRYFHKTKAQNLGAHAARHDMLFFCDCDIIVEPDAIVSLVRKLDAAPGAFATLKGVRETEQNARQAKNVVRFGYRLDVRIRNGRELTIVDNEEDAQDGTRQAPGLLFVRRRDFLAVNGYNGRLHGWGWEDQDMISRLTLGAGLVRHVEGHALHISHDDHARVSQYPMENRWESRDKMFRQALAYYDDDDFLGTYAQDVELFAAQAGLACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T11</accession>
    <name>Q63T11_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ordered locus">BPSL2160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193235.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108755.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2160"/>
    <dbReference type="MEROPS" id="M24.001"/>
    <dbReference type="EnsemblBacteria" id="CAH36162">
        <property type="protein sequence ID" value="CAH36162"/>
        <property type="gene ID" value="BPSL2160"/>
    </dbReference>
    <dbReference type="GeneID" id="56595945"/>
    <dbReference type="KEGG" id="bps:BPSL2160"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3291"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="13"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="271" mass="29616" checksum="A74183A274668F08" modified="2004-10-25" version="1">MAITLKNEHDIAQMRIACRLASEVLDYITPFVVAGVTTGELDRLCHEYMTHVQGTVPAPLNYQPPGYPPFPKAICTSVNDVICHGIPGEKTLKNGDALNIDITVIKNGYFGDTSRMFIIGEGSILAKRLVQTTYECMWLGIDQVRPGAHLGDIGHAIQKHAEAQGYSVVREYCGHGIGTVFHEDPQVVHYGRPGTGIELKPGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEHTILVTDTGHEVLTVSAGTPARPTFAAPATAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T14</accession>
    <name>PYRH_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridylate kinase</fullName>
            <shortName evidence="1">UK</shortName>
            <ecNumber evidence="1">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphate kinase</fullName>
            <shortName evidence="1">UMP kinase</shortName>
            <shortName evidence="1">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrH</name>
        <name type="synonym">smbA</name>
        <name type="ordered locus">BPSL2157</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193606.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108752.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T14"/>
    <dbReference type="SMR" id="Q63T14"/>
    <dbReference type="STRING" id="272560.BPSL2157"/>
    <dbReference type="EnsemblBacteria" id="CAH36159">
        <property type="protein sequence ID" value="CAH36159"/>
        <property type="gene ID" value="BPSL2157"/>
    </dbReference>
    <dbReference type="GeneID" id="56595942"/>
    <dbReference type="KEGG" id="bps:BPSL2157"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3295"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000323812" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <sequence length="237" mass="25329" checksum="DAF4639B10D5EFE8" modified="2004-10-25" version="1">MPNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGKVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRYSSISFDEAIGRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVQGEDEGTLVHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63T70</accession>
    <name>ISPD_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">MEP cytidylyltransferase</fullName>
            <shortName evidence="1">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispD</name>
        <name type="ordered locus">BPSL2099</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191584.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108696.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63T70"/>
    <dbReference type="SMR" id="Q63T70"/>
    <dbReference type="STRING" id="272560.BPSL2099"/>
    <dbReference type="EnsemblBacteria" id="CAH36102">
        <property type="protein sequence ID" value="CAH36102"/>
        <property type="gene ID" value="BPSL2099"/>
    </dbReference>
    <dbReference type="GeneID" id="56595886"/>
    <dbReference type="KEGG" id="bps:BPSL2099"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3380"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237777" description="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <sequence length="236" mass="25379" checksum="D300560FDC700BF6" modified="2004-10-25" version="1">MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGASRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNGLWQAQTPQMFRIGMLRDAIRRAQLDGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAQPARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TB8</accession>
    <name>Q63TB8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4123 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004535790.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108648.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2049"/>
    <dbReference type="EnsemblBacteria" id="CAH36050">
        <property type="protein sequence ID" value="CAH36050"/>
        <property type="gene ID" value="BPSL2049"/>
    </dbReference>
    <dbReference type="GeneID" id="56526413"/>
    <dbReference type="KEGG" id="bps:BPSL2049"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.33"/>
    <dbReference type="eggNOG" id="ENOG5032WWP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YLRERQD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025391">
        <property type="entry name" value="DUF4123"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13503">
        <property type="entry name" value="DUF4123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4123" evidence="1">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="277" mass="29923" checksum="5171C8E484BC4274" modified="2004-10-25" version="1">MATERFDWIDPYPARTLPRLRQVLDAPLTHGRWYALVDMGFSPTLREALAALNPDGAVIALYEGVYDGDGLLEISPCVTPLPDDAAHRAEVCAGLLRETDGRPMLSVLRAAHGLDALVAHLRGQMEARAADDEAFLVRLADTRCVPTWAGVLTPAQRARFFAGIDAWWLFDRAASLVELDVAPAGSETATGADDGEPYRLDGEQIAALRHASKIDTLLFHVRQRPESFGRLTATPSQAYACVSEAWAKEDVPPSAGARQALDALEAAGWLVPAEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TH6</accession>
    <name>Q63TH6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sugar ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSL1992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192697.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108590.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1992"/>
    <dbReference type="EnsemblBacteria" id="CAH35991">
        <property type="protein sequence ID" value="CAH35991"/>
        <property type="gene ID" value="BPSL1992"/>
    </dbReference>
    <dbReference type="GeneID" id="56595405"/>
    <dbReference type="KEGG" id="bps:BPSL1992"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4144"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SMFSYQM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH35991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="381" mass="40575" checksum="447E94ABC7732559" modified="2004-10-25" version="1">MGVVGKHMSAHAHEKPQPGAASDERLRGEAWFQRFLNRPEFAAISGAVLVFAVFAFGAGGSGMFNLDGIMNWSQVAAYLGILAVGACLLMVAGEFDLSIGSMIGFAGMMVAIPTVYFHWPIWLAVLFAFAGSMALGALNGYLVMRTKLPSFIVTLAFLFILRGLTLALSIMFADRTIVSGLGDYAHADPVVHFLFQGVAFHELFRSLAHAGVGRLLDNGEPLVPGVPKVLLWWLAVTAVGAFVLAKTRYGNWILAAGGDAHAAKNVGVPVRRVKISLFVLTAFCACLFAVLQVADIGSAAADRGLQKEFEAIIAAVIGGTLLTGGYGSVIGAAFGALIFGVVQIGITYTNISSDWFRVFLGVMLLVAVLFNHYVRRRVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TK7</accession>
    <name>Q63TK7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="10">ETF-QO</shortName>
            <ecNumber evidence="10">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSL1961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="10"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004193882.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108559.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1961"/>
    <dbReference type="EnsemblBacteria" id="CAH35960">
        <property type="protein sequence ID" value="CAH35960"/>
        <property type="gene ID" value="BPSL1961"/>
    </dbReference>
    <dbReference type="GeneID" id="56595503"/>
    <dbReference type="KEGG" id="bps:BPSL1961"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4109"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGGWMYH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="PTHR10617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="9 10" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH35960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="557" mass="60722" checksum="9C19AE40BF4491F6" modified="2004-10-25" version="1">MTPASLIEQYGPRESMEYDVVIVGGGPAGLSAAIRLKQLAAEKGAEIGVCVLEKGSEIGAHILSGAVMDPRAITELFPDWKEKGAPLNVDVTEDRFLFLTEKSSFQVPNWALPDNFKNHGNYVISLGNVTRWLGQQAEALGVEIFPGFPAAEILYNDDGSVKGVATGNMGVGKDGEPTENFQLGMELHAKYTLFCEGARGHLGRQLMDKFKLNANSDPQAYGIGIKELWEIDPVKHKPGLVIHTAGWPLSSDTYGGSFLYHMDNNQVVVGFVVGLAYSNPYLSPFEEFQRYKTHPAIRPFLEGGKRVSYGARAITAGGLLSLPKTVFPGGALVGDDAGFLNASRIKGSHAAIKTGMLAAEAAFDAVQAGRQADELTAYPDAFKTSWLHTELYRARNFKQWMGKGLYLGTLMVGVEQKLMNGNVPWTLHHQHGDHEMLKPASQCQPIDYPKPDGKLTFDRLSSVFISNTNHEENQPAHLTLKDASVPVNVNLRTYAGPEARFCPAAVYEFVKNDDGSDRLVINAQNCVHCKTCDIKDPTQNIVWVTPEGGGGPNYPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TN2</accession>
    <name>Q63TN2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108534.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1935"/>
    <dbReference type="EnsemblBacteria" id="CAH35934">
        <property type="protein sequence ID" value="CAH35934"/>
        <property type="gene ID" value="BPSL1935"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1935"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2181"/>
    <dbReference type="eggNOG" id="ENOG502Z86S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PRWYYSC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021847">
        <property type="entry name" value="DUF3443"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11925">
        <property type="entry name" value="DUF3443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="355" mass="35765" checksum="2E7AD9480D67F490" modified="2004-10-25" version="1">MQPVTASAGITGAANMLMTSVTVCVPNTNQCQTIDNVQVDTGSDGLRILAAALPSSVALPVVPAANAPITGACAIFGTGFTWGAVRRADVRIAGEIAANIPIQVIADSSTPNAPIDCTQSAGPMQTQGALRANGILGIGLFVTDCGTACANSALPGWYYGCTTSGTCASTSQPIAQQIANPIGAFASDNNGSIIVLPAISPTGAATVNGSLIFGIGTQANNGLGTATPLVTTASDAYVTSVLNGNTNARTFFDSGSNGIFFANASLPQCGSWFCPASTQTFDITLSSGNGASKATTFQVASSQVLFSTFNFAFNDLAGPIGNVVDLGLSFFYGRNVYTALEGSATPAGPGPYYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TP2</accession>
    <name>Q63TP2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108524.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1924"/>
    <dbReference type="EnsemblBacteria" id="CAH35924">
        <property type="protein sequence ID" value="CAH35924"/>
        <property type="gene ID" value="BPSL1924"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1924"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.2170"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LFCEEPA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="132" mass="14873" checksum="35FFC0B750E524B6" modified="2004-10-25" version="1">MLFDDLRDNEWALLEGLFCSEPARSERRGRPRVEARSVVNAVLWVLSTGEGWSKLPGRYPSPPTCRRRFDEWQADGTLAEVVKRLGTSGRQISLRGRIGASAVKPPAPPSRDRLRGAFWTNPESWRAPVKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63TZ8</accession>
    <name>Q63TZ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fimbriae-assembly related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL1819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205080.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108418.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1819"/>
    <dbReference type="EnsemblBacteria" id="CAH35818">
        <property type="protein sequence ID" value="CAH35818"/>
        <property type="gene ID" value="BPSL1819"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1819"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3940"/>
    <dbReference type="eggNOG" id="COG3745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DVIMTRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RcpC" evidence="2">
        <location>
            <begin position="132"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="350" mass="35216" checksum="3A8AC8D7C8A2D944" modified="2004-10-25" version="1">MSHFLKLAGLMLVAVVGAFLFRVLYVAASQPRPAAPPQQVRVRVAAADLPAGLLLRDADLGWKTMARSAAPAGALIEGDARGDGKAAGAANDASAAAAGEPKTDLKGDLLRHPVRAGAPLGPADVISPSAPGFLAAALKPGMRAISVAIDDVSGNAGLIEPGDYVDVLLTQQLAAPGGTPADPQRAVESETIAARLRVLAVGSAFQRPKDDAAQPNTRARTVTFEVSSRDAQVITVGAHLGALSLALRSFATSDRGAVGTAPAEPPAPPVWAGDVSRALRAQAPAEAPAQPRRVGAARAQAERRVIVYRGSKQDDAASAGAPLPGGVPPIPTLPPLPGAAAPPAGARPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UB5</accession>
    <name>Q63UB5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSL1696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108301.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1696"/>
    <dbReference type="EnsemblBacteria" id="CAH35695">
        <property type="protein sequence ID" value="CAH35695"/>
        <property type="gene ID" value="BPSL1696"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1696"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MALKMYD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00398">
        <property type="entry name" value="RECOMBINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="214" mass="23739" checksum="2E88584AF31E6C60" modified="2004-10-25" version="1">MQCSVKPEVTMRIGYARVSTEEQCLALQEDALTRAGCDLIFSDHGISGTNFCRPGLDQALQHLGRGDTLVVWRLDRLGRSLTKLVDMIDLLGQRDIHFESLTESINTQSPSGTLIFHIIAALAQFERALISERTRAGLAAAKNRGVRVGRPRSLTEYQASQAIRLLSERSIAAVAKEFGVHPQTLRRLWAIHKRHTESAGEFNESSTSPCVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UK8</accession>
    <name>Q63UK8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP-ase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191695.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108208.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1592"/>
    <dbReference type="EnsemblBacteria" id="CAH35591">
        <property type="protein sequence ID" value="CAH35591"/>
        <property type="gene ID" value="BPSL1592"/>
    </dbReference>
    <dbReference type="GeneID" id="56529313"/>
    <dbReference type="KEGG" id="bps:BPSL1592"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3646"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YRQRRFV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="23036" checksum="AA6B293529E2411D" modified="2004-10-25" version="1">MTYLVFFCGHAGTGKTTLAKRLIRPLMKTTGEAFCLLDKDTLYGRYSSAAMGALTHDPNDRDSPLYLKHLRDPEYQGLLDTARENLELGISAIVVGPLSREVRDRRLFDRAWLGIGPDVELRIVWVHTSEETAHARIVARGNPNDAYKLAHWDEYRQRRFIPTGEQCEGLLMFDNTAPSDADIDALRDHIAPPPARGVSTVPPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q63UN0</accession>
    <name>Q63UN0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205025.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108186.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1566"/>
    <dbReference type="EnsemblBacteria" id="CAH35567">
        <property type="protein sequence ID" value="CAH35567"/>
        <property type="gene ID" value="BPSL1566"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1566"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3616"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YNVFAGQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001442436" evidence="2">
        <location>
            <begin position="26"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="634" mass="64619" checksum="AFAB2ABAE7A5683F" modified="2004-10-25" version="1">MRVSIPSLPSLAPRALAAAAAIAFAGALAGCALFAPSDAPPAMPSPAHYGATPLPERTAAAQGLAQRFDVGAQPVPDWWKRYRSPALDALVDEGLRNSPTLAAAEKSLSAAREQLRAQIGSSLLPTIDAGGQATRERALGMPAFGPQTVLYNVFAGQLQASYTLDLFGAARFANRALSKRVDVNAYQLESARRALAANIVTAAVTSAALAEQVATTERLVALAREQASDAAARHRLGAASRTDMLNTRQSAAALEASLPALRQQAQSARHALAVLLGRTPDAAPANLALADLHLPQDVPVVVPSTLLQARPDIRAAEAGLQAAAAEVGVATAQMFPQLSLSASMGHAGFKWPAMLSGAGAIWSVGASLTQPLFHGGALLAQRRAARASYDAAVDQYKQTVLAAFQDVADKLAALENDASALDASNRSAVAARGAFDDTAARVRLGALPPSAARASEQQYRNARLDEIRATGTRLVDTARLFQAMGTPIDGGPDARRVGGMSGSNDVSDVSGSSGVGGAHRVIDIHEAGAAQRADDAKRTGDARMLRANGKTEAAQASVTASAAADAPAAPAPAAAASGANAIRIQARTPPTAGLSAGAIDGPIDAASATGATSTARPANGRDTTVESNPTHSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V10</accession>
    <name>Q63V10_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108056.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1434"/>
    <dbReference type="EnsemblBacteria" id="CAH35436">
        <property type="protein sequence ID" value="CAH35436"/>
        <property type="gene ID" value="BPSL1434"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1434"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1609"/>
    <dbReference type="eggNOG" id="COG0354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VNFKKGC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="317" mass="33272" checksum="F3263ACE3369F319" modified="2004-10-25" version="1">MLERGAFAALEQFGIVDVTGADAATFLHGQLTNDVEHLDAASARLAGYCSPKGRLLASFLAWRAGHDVRLLVSKDVQPAVQKRLSMFVLRAKAKLADASGALVAIGFAGDVRAALSGIFDALPDGIHTKVDAPAGALMRLPDAAGRARYLWIATRAEFDARLPALEAALPRVSAAVWDWLDVRAGEPRITQPAVEQFVPQMVNFDVIGGVNFRKGCYPGQEVVARSQYRGTIKRRTALAHVAAGTDAAHAGVELYHSDDPGQPCGMIVNAAAAPEGGVDALVEIKLAALGNGSVHLASASGPTLAFLPLPYALPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V17</accession>
    <name>Q63V17_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL1427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108049.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH35429">
        <property type="protein sequence ID" value="CAH35429"/>
        <property type="gene ID" value="BPSL1427"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1427"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1602"/>
    <dbReference type="OMA" id="HAPPECK"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH35429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="179" mass="20184" checksum="BC18B4AFD15361B8" modified="2004-10-25" version="1">MDRRRERRDVGGGFAHAPPECKERKVFPKESTIRALIERWNRHYSTVLGIKSATERSERIAHDLYLVRNAGFGGVSPPPNLPGNLVDKDDEIMACVEHYFLTRDWVANGKYPAWEARTLSGIYHLGKRIGVAPRHNKAKPVTPASPLQRALQLEGIKDGTIDRKLAGIQSPLVRKPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V25</accession>
    <name>Q63V25_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550298.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108041.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1419"/>
    <dbReference type="EnsemblBacteria" id="CAH35421">
        <property type="protein sequence ID" value="CAH35421"/>
        <property type="gene ID" value="BPSL1419"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1419"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3438"/>
    <dbReference type="eggNOG" id="COG0271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TRVEIHR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="104" mass="10901" checksum="5BC8A8DCA85B0542" modified="2004-10-25" version="1">MSDAFLHAAPAERIALIEARLAAALAPESIDVRDDSAQHAGHAGAAAGGHYTVTIVAAAFAGKSRVARHRLVYDALADAMQRGIHALAIVAYTPEEYPDSSRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63V70</accession>
    <name>Q63V70_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSL1371A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107996.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1371A"/>
    <dbReference type="EnsemblBacteria" id="CAH35369">
        <property type="protein sequence ID" value="CAH35369"/>
        <property type="gene ID" value="BPSL1371A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1371A"/>
    <dbReference type="OMA" id="ICGIAYR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="184" mass="20067" checksum="BB8A014FE687AB2F" modified="2004-10-25" version="1">MQTTDHCARAMRRPSETVRRLGGAKRSVASAGPGPRLWRMAAAGFAAVAGIAPAHRSRPASRATGSSSAKRRAALSSSARGPQPGGSSEEVGAFSARVPRFEPIDASEEFAHLAFERRVFVEALPDRIEPEPPICGIAYRRMMDEFLSRFLEDPDCHLEMGQFARDITMPVHCRTLRSCSPRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VF1</accession>
    <name>Q63VF1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1293"/>
    <dbReference type="EnsemblBacteria" id="CAH35288">
        <property type="protein sequence ID" value="CAH35288"/>
        <property type="gene ID" value="BPSL1293"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1293"/>
    <dbReference type="eggNOG" id="COG4117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MTQTMTQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="58"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="248" mass="27090" checksum="D9E4DF555C6E97CF" modified="2004-10-25" version="1">MSQTMSQTMAQTMAQTMAQTMTQTMTQAGTEAASPAGTDAAASGTCITRATRARRPIHPLWVRASHWLNALAAVTMALSGWRIYNASPIYAGFVFPRGATLGGWLGGALQWHFAAMWLLFFNGVFYLTMGVATGRFTRKLLPLSASGVARDLRDALRGRLSHDDLSVYNALQRAAYVAAIADLALLVLSGLVIWKSVQFPLLREWLGGYDRARVVHFWAMAFLVAFFVVHVAMAALVPRSLLAMLRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VJ2</accession>
    <name>Q63VJ2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein/sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL1253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526483.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107874.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1253"/>
    <dbReference type="EnsemblBacteria" id="CAH35247">
        <property type="protein sequence ID" value="CAH35247"/>
        <property type="gene ID" value="BPSL1253"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1253"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.266"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MAGTHML"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033424">
        <property type="entry name" value="MASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17158">
        <property type="entry name" value="MASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="369"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="575" mass="63782" checksum="0E4D9C6585703781" modified="2004-10-25" version="1">MGELADESRIFLSTLQPERRERRLAMTAVALSVVLFATLAPFVRIQMPQVWAFIPIYQSAIVICDLITAGLLLGQFGILRTPSLVVLAGGYLFTACMASVHMLTFPGLFLPSGLLDAGPQTTAWLYMFWHSGFPLCVIFYTLASRRERAEPLYAGRLALPVIVCIGTALVATGAFAALATSGRELLPPIMANNHYTPLMRGVVTTVWLMTLAALILLTSRRPHSVLDLWLIVVLCAWLLDIALSAVLNHGRFDLGFYAGRVYGLVASSFVLLALLLENGKLYARTVHALQGERIEHRRVQEKTVQLNEANELLEQRVAERTRELQAANDELRREIVERERAEEALARSREELREIAAISSTAREQERGRIARELHDELAQTLAMLRLDLERVSTTGNELAGSFMEMRGLLDGAVAATRRIASDLRPLMLDDLGLVPAIQWLVQAFQQRHGIDCTLIVDPPELDLVEPQASTTFRILQESLTNVGRHARASHVDIRLIADDREVMLSVRDNGVGFDTENPRKPNSFGLVGLRERAYLVQGTLSVQTAPGQGTAIEVHIPLVRAREVTVLQSGELRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63VM4</accession>
    <name>Q63VM4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nuoJ</name>
        <name evidence="3" type="ordered locus">BPSL1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004185672.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107842.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1220"/>
    <dbReference type="EnsemblBacteria" id="CAH35215">
        <property type="protein sequence ID" value="CAH35215"/>
        <property type="gene ID" value="BPSL1220"/>
    </dbReference>
    <dbReference type="GeneID" id="56595154"/>
    <dbReference type="KEGG" id="bps:BPSL1220"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.306"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MLVNKRE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="218" mass="23642" checksum="285EB6043D93F873" modified="2004-10-25" version="1">MDFTTVLFYIFSLLLVVSGLKVITSRNPVASALFLVLAFFNAAAIWMLLEAEFLAILLVLVYVGAVMVLFLFVVMMLDVNIDVLRRDFKRFVPMATAVGAIIVVETALILWRGYGATASPVRDMAAGALAGMPNTKLIGKVIYTDYIFAFEIAGLVLLVAIIAAVALTAQKGKDSKRQRVSEQVKVRREDRVRLVKMPADKPQPEAAASDAASGSNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W11</accession>
    <name>Q63W11_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107705.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1083"/>
    <dbReference type="EnsemblBacteria" id="CAH35077">
        <property type="protein sequence ID" value="CAH35077"/>
        <property type="gene ID" value="BPSL1083"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1083"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1176"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GGCFNNY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="44233" checksum="417310D7711AB124" modified="2004-10-25" version="1">MTPTEETMNPSDLKPPRWALSERARKLTSSAIREILKVTERPEVISFAGGLPSPATFPAERMREAAERVLRDSPAAALQYSATEGFLPLREWIAERYRVRTTQVLVTTGSQQALDLLGKVLIDPASRVLVETPTYLGALQSFSLYEPIYAQVPTDDAGLLPEALTPELTKDARLLYAQPNFQNPTGRRLSVERRRALAAFARTSPFPVLEDDPYGALNYAGEPLPTMLSMAPDHIVHLGTFSKVLAPGLRIGYIIAPEELHFKLVQAKQATDLHTPSLTQRIAHEVIQDGFLDAHIPTIRKLYGAQCEAMLASLARHMPQGVSWNRPEGGMFIWVTLPAQIDSMQLLETAVANNVAFVPGAPFFANDAQKNTLRLSFVTVPPEKIEEGVARLGKLLRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63W12</accession>
    <name>Q63W12_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YjgF_endoribonc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107704.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL1082"/>
    <dbReference type="EnsemblBacteria" id="CAH35076">
        <property type="protein sequence ID" value="CAH35076"/>
        <property type="gene ID" value="BPSL1082"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL1082"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1175"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FLAGKGP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="16278" checksum="84DDE7C4AB8D2AD4" modified="2004-10-25" version="1">MNQMANVYDKLKELGIELPVAGAPAAAYVMSAQSGNTVYLSGHIAKKDGKVWAGKLGLDVTTEQGKLAARAVAIDLLATLHAHTGDLNKVKRIVKVMSLVNSTLEFTEQHIVTNGASELIAEVFGDAGKHARSAFGVAQIPLGACVEIELIAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WE4</accession>
    <name>Q63WE4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative insertion element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009936644.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107572.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0943"/>
    <dbReference type="EnsemblBacteria" id="CAH34939">
        <property type="protein sequence ID" value="CAH34939"/>
        <property type="gene ID" value="BPSL0943"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0943"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.1026"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ARSTHYY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="99"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="31586" checksum="9C80A605F7D5FB55" modified="2004-10-25" version="1">MTERTMGVTRACGLVGISRSLLHYESRRRVDDEALTGRMMAIAAQKRRYGYRRIHVLLQRDGCFANHKRIWRLYSKAGLSVRKRRRKRIAAVERTPLPLPTGPNQSWSMDFVSDGLAYGRRFRCLNVVDDYTRECLAIEVDTSLPGLRVQQVLARLKEMRGLPASITVDNGPEFAGKVLDAWAYEAGVTLSFIRPGKPVENAYIESFNGRFRDECLNEHWFVSMRHAKQLIEEWRIEYNTERPHSSLGYLTPAQFARAHDAKQQFLTSDSNCSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WV9</accession>
    <name>Q63WV9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative type 4 fimbrial pilin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-Me-Phe pilin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526211.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107407.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0782"/>
    <dbReference type="EnsemblBacteria" id="CAH34774">
        <property type="protein sequence ID" value="CAH34774"/>
        <property type="gene ID" value="BPSL0782"/>
    </dbReference>
    <dbReference type="GeneID" id="56596593"/>
    <dbReference type="KEGG" id="bps:BPSL0782"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.839"/>
    <dbReference type="eggNOG" id="COG4969">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="APPECRS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001082">
        <property type="entry name" value="Pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00114">
        <property type="entry name" value="Pilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="172" mass="17264" checksum="89C387C49DA0E3B2" modified="2004-10-25" version="1">MRARGFTLIELMIVLAIVGVVAAYAIPAYQDYLARSRVGEGLALAASARLAVAENAASGNGFSGGYVSPPATRNVDSIRVDDDSGQIVVAFTTRVAAAGANTLVLVPSAPDQADTPTARVALSKGAVQAGAITWECFADGKASSSLPAPGAGPLPTDAPTLAGKLAPPECRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63WZ9</accession>
    <name>Q63WZ9_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1863 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004526201.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107367.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0741"/>
    <dbReference type="DNASU" id="3092842"/>
    <dbReference type="EnsemblBacteria" id="CAH34733">
        <property type="protein sequence ID" value="CAH34733"/>
        <property type="gene ID" value="BPSL0741"/>
    </dbReference>
    <dbReference type="GeneID" id="56527053"/>
    <dbReference type="KEGG" id="bps:BPSL0741"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.864"/>
    <dbReference type="eggNOG" id="ENOG5030R27">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DCKTETI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015032">
        <property type="entry name" value="MTH538_TIR-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08937">
        <property type="entry name" value="DUF1863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1863" evidence="1">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="185" mass="20750" checksum="8432867AAE022867" modified="2004-10-25" version="1">MAYRNGTYVAFHANGTNRPGGNSDIDYYNLLKAWVGKDDDHFTMNNSHDKASAVRDSSKKETLRASLLERLRNSKNMVLIIGDTTLLDDDWVPFEISSAVDTYEIPIIAVYTQYSTPIRNPAALRSRWPDALATRIDSQKAKVIHIPFKKAALNDAISQFSHNNMPKGPLSFYSDEAYESFGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X84</accession>
    <name>Q63X84_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188943.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107282.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0653"/>
    <dbReference type="EnsemblBacteria" id="CAH34646">
        <property type="protein sequence ID" value="CAH34646"/>
        <property type="gene ID" value="BPSL0653"/>
    </dbReference>
    <dbReference type="GeneID" id="56596652"/>
    <dbReference type="KEGG" id="bps:BPSL0653"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.969"/>
    <dbReference type="eggNOG" id="ENOG502ZV3X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKLDTCG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013481">
        <property type="entry name" value="CHP02664_NO3_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09655">
        <property type="entry name" value="Nitr_red_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02664">
        <property type="entry name" value="nitr_red_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="159" mass="18171" checksum="4677ADFD41DEC656" modified="2004-10-25" version="1">MGLSDAPLLFNFEIESSEDLTYIPMIVRFNLDRFGLRISLEQWQMLPLEDRRLLARFPADEDVVIEPNFDHALFEMLRTHANVEPSWFQPDEHPAWRSVDAVPDALVAQSGLAGLPAPSASQWATLTPFQRYVLTKLSRKPKLNHDFVPAMREFGLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63X90</accession>
    <name>Q63X90_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189774.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107276.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0647"/>
    <dbReference type="EnsemblBacteria" id="CAH34640">
        <property type="protein sequence ID" value="CAH34640"/>
        <property type="gene ID" value="BPSL0647"/>
    </dbReference>
    <dbReference type="GeneID" id="60547235"/>
    <dbReference type="KEGG" id="bps:BPSL0647"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.975"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VIREYHT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="22747" checksum="B2EE3A10316BE199" modified="2004-10-25" version="1">MRKGEQTRAAILEAALDLASRDGLEGLTIGLLAERMQMSKSGVFAHFGSRDDLQVEVVREYHHRFENEVFFPSLREPRGLPRLRAMLARWIEKRIQEVTTGCIYISGAVEYDDRPDSAVREQLIASVKAWRAALLRAISQAKEEGHLRPDTDPNLMLFELYSFTLGLHHDARFLHQPDAVRLTWAALEKTIVSYQSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XA5</accession>
    <name>Q63XA5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189219.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107260.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0631"/>
    <dbReference type="EnsemblBacteria" id="CAH34624">
        <property type="protein sequence ID" value="CAH34624"/>
        <property type="gene ID" value="BPSL0631"/>
    </dbReference>
    <dbReference type="GeneID" id="56596676"/>
    <dbReference type="KEGG" id="bps:BPSL0631"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.993"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PMDPVTM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="128" mass="13831" checksum="60E59B665C656717" modified="2004-10-25" version="1">MKRYGVGEAKGTGGQVMPFARAVEADGWLYVSGQTPMVNGEVVEGGIVTQSKQAIENVIAILKEAGYGLEHVVRCGVWLDDARDFASFNKVFISYFGEHPPARACVQSSMVIDCKVEVDCIAYKAPAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XM1</accession>
    <name>HIS81_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol-phosphate aminotransferase 1</fullName>
            <ecNumber evidence="1">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazole acetol-phosphate transaminase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisC1</name>
        <name type="ordered locus">BPSL0518</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530940.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107144.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63XM1"/>
    <dbReference type="SMR" id="Q63XM1"/>
    <dbReference type="STRING" id="272560.BPSL0518"/>
    <dbReference type="EnsemblBacteria" id="CAH34508">
        <property type="protein sequence ID" value="CAH34508"/>
        <property type="gene ID" value="BPSL0518"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0518"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1129"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FDGYPIL"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000153338" description="Histidinol-phosphate aminotransferase 1">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <sequence length="356" mass="39286" checksum="2552F2D2AFA5C806" modified="2004-10-25" version="1">MSRYWSDIVRQLEPYVPGEQPALAHPVKLNTNENPYPPSPRALDAIRRELGDTGEALRRYPDPVARRLRETVAAYHGIAPEQVFAGNGSDEVLAHAFQALLQHDRPLRFPDITYSFYPTYARLYRVAYETVPLADDFSIVVDDYLDDAGCVLFPNPNAPTGRALPLADIERIVAANPSSVVVIDEAYVDFGAESAVSLIARYPNLLVVHTVSKARSLAGMRVGFAFGDAALIDALTRVKDSFNSYPLDRLAQVATQASYEDEAWFQATRKQVIASRERLVGALAALGFDVVPSAANFVFARPRSHDAATLAAQLKQREIFVRHFKLPRIDQHLRITVGSDAECDALVAALRELLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q63XV5</accession>
    <name>Q63XV5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">BPSL0435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_107060.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0435"/>
    <dbReference type="EnsemblBacteria" id="CAH34423">
        <property type="protein sequence ID" value="CAH34423"/>
        <property type="gene ID" value="BPSL0435"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0435"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.489"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IWLSIMS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266658" description="Ammonium transporter" evidence="9">
        <location>
            <begin position="20"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="98"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH34423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="495" mass="49966" checksum="C10E316B57B50A96" modified="2004-10-25" version="1">MSLLMAGSLLAGGIGAAMADDASSAPAAASAATASDTSAGAAASAPAASAAPAAPAAPAASAPAAASAAAPASAAAAPAAPTAPFSVDSSKINSGDTAWMLTSTALVLFMTIPGLALFYGGMVRKKNVLATVMQSFAITALITVLWTVVGYSLAFTPGNGFIGGFSRVFLSGMNYIHGDKATTLTVSHLASTIPESVYFVYQMTFAIITPALICGAFADRMKFSAMLVFMTLWSLIVYVPIAHMVWEPTGWLSADGVLDFAGGTVVHINAGIAGLVSCLMLGKRVGYGREAMAPHNLVLTLIGGSMLWVGWFGFNAGSAVAADGRAGFAMLTTQVATACAALGWMFAEWIAKGKPSVLGIVSGAVAGLVAITPAAGFVGVAGALVIGIAAGVVCFWSATWLKHKLGYDDSLDAFGVHGVGGILGALLTGVFAVKDIGGADGSLLLQAKGVAITLVYSGIVSFVLLKVIDIVIGLRVTEEEEREGLDVILHGEHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Y71</accession>
    <name>Q63Y71_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSL0317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189567.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106944.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0317"/>
    <dbReference type="EnsemblBacteria" id="CAH34306">
        <property type="protein sequence ID" value="CAH34306"/>
        <property type="gene ID" value="BPSL0317"/>
    </dbReference>
    <dbReference type="GeneID" id="56594647"/>
    <dbReference type="KEGG" id="bps:BPSL0317"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1370"/>
    <dbReference type="eggNOG" id="COG1565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="396" mass="42101" checksum="EE60045856C2E1CE" modified="2004-10-25" version="1">MNPKAHEPASLPVPGPDALAQSDALAASLRAEIAAAGGWIPFSRYMERVLYAPGLGYYSGGAQKFGRRGDDGSDFVTAPELSPLFAQTLARPVAQALAASGTRRVMEFGAGTGQLAAGLLNALAALGVELDEYAIVDLSGELRARQRETLDEQASGAAARVRWLDALPERFEGVIVGNEVLDAMPVQLVAKHAHGWCERGVSLGDAGAFAFADRPLARAEDAARLAALDADEGYVTETHDAAAAFVGTVCAMLARGAALFIDYGFPRHEYYHRQRAQGTLMCHYRHRAHGDPFVYPGLQDITAHVEFSAVYEAGVGAGAELLGYTSQARFLLNAGITDVLAEIDPSDAQRFLPAANAVQKLISEAEMGELFKVIAFSRGIDGTLDAFARGDRSHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YA0</accession>
    <name>Q63YA0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525908.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106915.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0288"/>
    <dbReference type="EnsemblBacteria" id="CAH34276">
        <property type="protein sequence ID" value="CAH34276"/>
        <property type="gene ID" value="BPSL0288"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0288"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1416"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WMRHTAF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="246" mass="25789" checksum="1A144B7D4C7E074A" modified="2004-10-25" version="1">MNLDAASRNLTVASLLTLSGGYLDAYTYVGHGHVFANTMTGNVALLGINVSAGDWAQALHHVPPLAGFVIAVFVAHTLGLAAQKGWVRHTAFISLIVEIGFLAFASAGWPAMSSAWLIPGISFVATLQTLSFTHLENLSYTSVMTTGNLRRAAQLLFAGLIPRYDALALHDSGLLAVISLCFLMGAVAGGFVTRLVGDGALWGAVLLLAAAFAEIVRRARHDSGAGAARAERAARDAPAERAAHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YG3</accession>
    <name>Q63YG3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL0224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550980.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106852.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0224"/>
    <dbReference type="EnsemblBacteria" id="CAH34212">
        <property type="protein sequence ID" value="CAH34212"/>
        <property type="gene ID" value="BPSL0224"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0224"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1488"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GWGWQDV"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="547" mass="58703" checksum="6C797CB909806BA0" modified="2004-10-25" version="1">MQYDYIIVGGGSGGASLAGRLADACPDATIALIEAGGHTERNLLVNMPVGIAALVPFKLGTNYGYETVPQPGLGGRRGYQPRGRGLGGSSAINAMIYTRGHPLDYDEWEQLGCTGWGWRDVLPYFRRAEGNARGANEWHGADGPLTVSDLRFRNPFSERFIAAAHEAGYPLNDDFNGEHQEGVGFYQVTHRDGSRCSVARAYVYGRTRPNLHVIVDATVLRVVFDGKRATGVEFARAGRTEQLAARAEVILSAGAFNTPQLLMCSGVGPAAQLRRHGVALVHDAPDVGENLIDHIDFIINKRVNSSELVGICMRGIAKMTPALFSYLSGRRGMMTSNVAEAGGFIKSEPGLDRPDLQLHFCTALVDDHNRNMHWGFGYSLHVCALRPKSRGNVALASGDARVAPLIDPRFFSDERDLDLLVTGAKAMRRILCAAPLASQGGRELYTDPGDTDAQLRAAIVAHADTIYHPVGTCRMGTDARAVVDPQLRVKGVDGLRVVDASVMPTLIGGNTNAPTVMIAERAADFIVAARNGQAAPARERIAATHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YK5</accession>
    <name>Q63YK5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan glycosyltransferase MrdB</fullName>
            <shortName evidence="6">PGT</shortName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
            <shortName evidence="6">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rodA</name>
        <name evidence="6" type="synonym">mrdB</name>
        <name evidence="7" type="ordered locus">BPSL0182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004189171.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106810.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0182"/>
    <dbReference type="EnsemblBacteria" id="CAH34169">
        <property type="protein sequence ID" value="CAH34169"/>
        <property type="gene ID" value="BPSL0182"/>
    </dbReference>
    <dbReference type="GeneID" id="56596696"/>
    <dbReference type="KEGG" id="bps:BPSL0182"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1537"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="382" mass="41563" checksum="B409E8B6E8A385EF" modified="2004-10-25" version="1">MQFDKRASLDKIKQMFAGFDRPLALIVFLLLCVGIVTLYSASVDVPGRVEDQLRNIMLTFVLMWVIANIPPQTLMRFAVPLYSFGVALLVAVALFGMTKKGAKRWLNVGVVIQPSEILKIATPLMLAWYYQRRESSLRWYDFVVAFAILMVPVGLIAKQPDLGTAVLVFAAGLFVIYLAGLSFKLIVPVLVAGVLAVGSIAVFEERICQPEVVWPLMHDYQKHRVCTLLDPTSDPLGKGFHTIQAVIAIGSGGPLGKGYLKGTQAHLEFIPEKHTDFIFAVFSEEFGLVGGLVLLTLYMALIARGLYIAAQGATLFGRLLAGSLTLAFFVYAFVNIGMVSGVLPVVGVPLPFMSYGGTALTTLGIAVGLIMSVGRQKRLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YR7</accession>
    <name>Q63YR7_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ordered locus">BPSL0121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525852.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106748.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0121"/>
    <dbReference type="EnsemblBacteria" id="CAH34107">
        <property type="protein sequence ID" value="CAH34107"/>
        <property type="gene ID" value="BPSL0121"/>
    </dbReference>
    <dbReference type="GeneID" id="56527592"/>
    <dbReference type="KEGG" id="bps:BPSL0121"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1602"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="167" mass="18981" checksum="F39E481F18D989A7" modified="2004-10-25" version="1">MALLNILHYPDKRLHKVAKPVAKVDDRIRKLVADMAETMYAAPGIGLAATQVDVHERVIVIDVSEDKNELRVFINPEIVWTGDGKQVYEEGCLSVPGVYDEVERPDRVRVRALDGQGEPFELDCEGLLAVCIQHEMDHLMGRVFVQYLSPLKQTRIKTKMKKLERAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YV6</accession>
    <name>Q63YV6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL0083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524588.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106709.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0083"/>
    <dbReference type="EnsemblBacteria" id="CAH34067">
        <property type="protein sequence ID" value="CAH34067"/>
        <property type="gene ID" value="BPSL0083"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0083"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1650"/>
    <dbReference type="eggNOG" id="ENOG50302A5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="113" mass="12319" checksum="E96EAEB4837B3BBC" modified="2004-10-25" version="1">MSQYVRTAVIEGFDNAPPLDTSAPIELQFAVDLGAVCADAWLELKGEVRLHDYAAFQVDAFVRGLNASMHDNGDIDTHHVTVSGHAFVAGLMGRVQQHLFAALGVTRYPRTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YX5</accession>
    <name>Q63YX5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011204737.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106690.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH34048">
        <property type="protein sequence ID" value="CAH34048"/>
        <property type="gene ID" value="BPSL0065"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0065"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1674"/>
    <dbReference type="eggNOG" id="ENOG5032SHM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MRIIRAW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267291" evidence="1">
        <location>
            <begin position="29"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="188" mass="20238" checksum="CC1C642338598B21" modified="2004-10-25" version="1">MRTIRAWLALTFVASIACLIATTPAARAAPAGKTLTFDGVAFFQRDAAGNRLEYTPKGEDDLSAWRTMITLVRYPEATTADGLASIADSVLRLYKQNGAMILKVDAVPAARGKPAEYFISVAFPTRDFIEAVFTRIALVDGSGAAAIYSHREYGRAVGNEVSAWIEKNGAAKERALKQWNPLPTAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YY3</accession>
    <name>Q63YY3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL0057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525796.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106682.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0057"/>
    <dbReference type="EnsemblBacteria" id="CAH34040">
        <property type="protein sequence ID" value="CAH34040"/>
        <property type="gene ID" value="BPSL0057"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0057"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1686"/>
    <dbReference type="eggNOG" id="COG4709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ESMAWDI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="395" mass="41217" checksum="C0E120F714929B79" modified="2004-10-25" version="1">MKQDAFIQRLRQALGSLPKRDVDEIVADYREYIGDALSAGRTEEDVIAALGEPEKLARELKAQANFRQWEERRSFGNLMRVVGSIAGLGLLHLVLLVPFLLYMLVLTLGYVFFGALTVAGLVTLVAFGSHYVFGTPVPGVLPFGGGAAQLGAAGASGKADGKGATDGKAAQTGKIAQDPKSASAAAADALNDAKELRVEGERYVLDLHDGSRVSIVTRKGVIDARKQGGKLSIDATGDGARELLTTGKDDTLGIARADVIALDLKSANGDQMTVANTGGSVPGVNVPGIAGGNVQMTPDGRGGMNLSVTNGENSVSIVGGRITVDNGKQHVSVAAPAGFALGGIAFGYGLAMLPIGIVGLLVCVWLTRVTWRALGRYVRRRIDAVSAKLERERAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63YZ3</accession>
    <name>Q63YZ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSL0047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004549855.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106672.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0047"/>
    <dbReference type="EnsemblBacteria" id="CAH34030">
        <property type="protein sequence ID" value="CAH34030"/>
        <property type="gene ID" value="BPSL0047"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL0047"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1696"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DMAFWIQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="240" mass="25512" checksum="021B3545149F112F" modified="2004-10-25" version="1">MIEISNLTVQFGGTRVLDALDAKLAAPICGLIGPNGAGKTTLLNVLSGFLRPRAGSVALDGRALLALSVAERVRAGVRRTFQTEQIVEDLSVHDNVLALAEHVMPALAARDDTRRALELVGLADVAHVQGAALNLYQRRMLELGKALVGVPRLLLLDEPGAGLNETEAARLADVIVRIPECVGAQVLLIDHDVDLIDAVCEATLVLDFGKRLALGPTRAVLDDPLVRSAYLGQAFDEHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q63Z04</accession>
    <name>Q63Z04_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSL0036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004202867.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_106661.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL0036"/>
    <dbReference type="EnsemblBacteria" id="CAH34019">
        <property type="protein sequence ID" value="CAH34019"/>
        <property type="gene ID" value="BPSL0036"/>
    </dbReference>
    <dbReference type="GeneID" id="56594122"/>
    <dbReference type="KEGG" id="bps:BPSL0036"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1710"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YPTSVLY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266449" evidence="1">
        <location>
            <begin position="29"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="337" mass="35295" checksum="B0F728888B134EC5" modified="2004-10-25" version="1">MRTTLRALSLAAVAAGLSFGFAAQPAFADDGGKITIMVGGITKLIYLPARLTQELGYFKAEGLDVELQSQPAGVDAENELLAGAVQGVVGFYDHTIDLQSKGKDVKAIAVLGQVPGEVEMVSTKAAGAIKSMADVKGKTLGVTGLGSSTSFLTQYLAQQHGIAANQYTMLPVGADASFIAAVKQGRIDAGMTTEPTVSVLEKNGDAKVLVDLRTLDGTRAALGGTYPAASLYVQSAWADTHKAQAAKLAHAFARTMQFIHTHSAEEIAAKMPADYQKDKALYVSALKASLPMYTPDGRMPADGPATVLKVLSAFNPSVKGKHIDLSKTYTNDFVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H7C744</accession>
    <name>H7C744_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wcbJ</name>
        <name evidence="2" type="ordered locus">BPSL2798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194206.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109393.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2798"/>
    <dbReference type="EnsemblBacteria" id="CAH36807">
        <property type="protein sequence ID" value="CAH36807"/>
        <property type="gene ID" value="BPSL2798"/>
    </dbReference>
    <dbReference type="GeneID" id="56594712"/>
    <dbReference type="KEGG" id="bps:BPSL2798"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2510"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PDICARE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="30836" checksum="537484FCC1F23CD4" modified="2012-04-18" version="1">MKVFLVGSTGYIGKTLFDACSRRWRTLGTSTRDGADIVFSLARAEAFPYEQVSAGDVVAVAAAISSPDACAKDYETAFQVNVTGTLTLIRGVVARGARVIFFSSDTVYGASEQLLSEEAELTPAGAYGAMKRRVEAELGENAAVKVIRLSYVFSLRDRFTQYLLGCAKEGKRADIFKPFSRCVVYLSDVVEGVVSLIERWDAIDERVINFVGPELVAREDFVEKIRNLAAPELDYGFSEPEGDFFVNRPRIINVSSARFEKLLGRRPRSLGEAINLELSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>H7C783</accession>
    <name>H7C783_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">BPSS1555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009934722.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111561.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1555"/>
    <dbReference type="MEROPS" id="M04.022"/>
    <dbReference type="EnsemblBacteria" id="CAH39028">
        <property type="protein sequence ID" value="CAH39028"/>
        <property type="gene ID" value="BPSS1555"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1555"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4916"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TFDAENM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023084954" description="Neutral metalloproteinase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="11">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="9">
        <location>
            <begin position="222"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="10">
        <location>
            <begin position="387"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAH39028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="565" mass="60019" checksum="FD391CCB92E9DD61" modified="2012-04-18" version="1">MKKLSCLLSVTAISLACLSAFAQADDPPAAADRALQLIRQNPSAFHLAAGSAARTLKFAGAQAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADVRRVDGADLVVFARDAAPTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQTGTNAYRMLDPTRGSGSVYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDPGNYVIGARITSGGLRKMYKQDLDGRSYSCYPSGGFSWANPRHDPHYTSGVGNRFFYLLAEGPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYTGARRASIQAANDLYGVNSLESATVARAWSAAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HW5</accession>
    <name>Q63HW5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">BPSS2304</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112307.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2304"/>
    <dbReference type="EnsemblBacteria" id="CAH39790">
        <property type="protein sequence ID" value="CAH39790"/>
        <property type="gene ID" value="BPSS2304"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2304"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6756"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVQMPYI"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="19">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="18">
        <location>
            <begin position="407"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="774"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAH39790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="839" mass="90084" checksum="A231087F7E313151" modified="2004-10-25" version="1">MSSFLERCAAWLAAAKPHAAAVLHRLRHPTRRGVLLAVAALPALCVLYVLALIPFTPSIGDIRKARVDAPAQILSADGKLLAEFKPSNREWVPLADISPKMVDALISTEDHRFYEHHGLDWRRTAGAALRTFSGDRQGGSTITQQLARNLYPDEIGRAPTLTRKLKEAITALKIEAVYSKAQILETYLNTVPFLYNAYGVEMAARTYFDKSADQLDALDAATLVGMLKGNSYYNPVLNPERALARRNTVLAQMVKYGRLSPAAYASLQKKPLRIDFERQKEPPGPAPHFAQQLRKWLIAWADRNDYNIYSDGLVVRTTIDSRLQTYATQALARQTNQLQGVANGMWNAGSGCAPGNPLFRAFVRETPEFRAALDGGATGDAALKRLLADRGFARALCKAKADVQAGFLAIDPRNGQIKAWVGSRDFTAEPFDHVQQARRQPGSTFKPFVYGAAFAAGATPDDTFVDQPVEIPLAGGEIWRPDDDAPPTNKPMTLRDAIAYSRNRITAQLMMKVGPQKVARLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYATIANVGEYVEPRMVTRIEGRNGEVLAEFASATPERALDAAAARTLIDVMRGVVERGTGAAIRSRYGIRADVAGKTGTTQGDTDGWFILMQPELVAGAWVGFDDGRVTLGGDWGQGARSALPIVGDFYQRAIRARLVDTRERFATEAPPSAFDTFRNKLGDWYRYLFEKPEPPRKAAPPKAPRAPLEEVMPASEVEAASAAVARAASEAAAVASAASTASAAPPASGVPFAPGGASAPALPPLLPPMPQSAPLPPAAQPGSSLPNDNAPMSPTPTPDAPAAGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63HY6</accession>
    <name>Q63HY6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112286.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2283"/>
    <dbReference type="EnsemblBacteria" id="CAH39769">
        <property type="protein sequence ID" value="CAH39769"/>
        <property type="gene ID" value="BPSS2283"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2283"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5901"/>
    <dbReference type="eggNOG" id="COG0645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FRFVDVM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="171"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="569" mass="62821" checksum="191B183F2B4D7975" modified="2004-10-25" version="1">MRRSRPPKPAKPAAVRRRPHGAARAHAIRGNGPQRRAVRERAARRLSRDIDAALRRASTYPHPAGPIVRIETHLSVVYLVGRFAYKRLKPFDFGFANFSELAARRRACEAELALNRPLAAPIYLAAGPLVRRARGLRLFGAGAAVDHVVRMRRFDERMLFSRLLARGALDAADIDAAATRLAAYHLHAPRDIPRRAYGSARELRRQLDDMLAPLERALGAALPASLRAWCVRRCDELAAHLDARRADGYVRACHGDLHLNNVVKRGRDALMFDCIDFDDALRWIDVINDLSFLLMDLHAHDRAALAHRLLNRWLDETGDFAGLAALPLYVAYRALVRALVATMRAGGDAAARAARIERARRYVDVAAHAARARRPCLLLCHGYSGSGKSVASRALADVSGAIRLSSDSERKRARPFAAVDARPLPASAYTPQQIDAQYERLRALARDVLRAGYTALVDATFLSHARRARFFALARELGVPVYVLDFHASRACLERRVDARAAARDDHSDAGAAVLATQRASADPLDADERARTIGFDTDVPLATLRSAGYWRPVLDALDAARVDAQATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63I91</accession>
    <name>Q63I91_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS2179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529399.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112181.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2179"/>
    <dbReference type="DNASU" id="3096173"/>
    <dbReference type="EnsemblBacteria" id="CAH39664">
        <property type="protein sequence ID" value="CAH39664"/>
        <property type="gene ID" value="BPSS2179"/>
    </dbReference>
    <dbReference type="GeneID" id="56531732"/>
    <dbReference type="KEGG" id="bps:BPSS2179"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5760"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QLIWEYP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="150" mass="17307" checksum="E6274C0AA8C76ABE" modified="2004-10-25" version="1">MSDNLCRTDLSSDAAAAVERVYREWDRAWAADDLDAMIALYAPDAVLESPLVTHLLGTESGVVEGRERIRALLEQAAPRKPEARMFHRIGYFTDGKRLIWEYPRATPTGEQMDFVEMMEIEHGLIRRHRVYWGWRGVSVIKADAYRKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IF5</accession>
    <name>Q63IF5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS2118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112117.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2118"/>
    <dbReference type="EnsemblBacteria" id="CAH39599">
        <property type="protein sequence ID" value="CAH39599"/>
        <property type="gene ID" value="BPSS2118"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2118"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6510"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RIHYRLA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="230" mass="25254" checksum="B51AA7B57A25F372" modified="2004-10-25" version="1">MTKEAQVSSAGPKQEIYESLAEVAQAVGHPNRLELLEHLAQRERSVEDLTALSGMSFANTSRHLQILRRARLVDTERRGKNVVYRLAGDSEVVGLMKALGRLGERNVAEVNRVLGDYFHARDSMEPVSRNELTARLADGLVTLLDVRPHDEFAQGHLPGALNIPLAALEARLSELPADTEIVAYCRGPYCVLAFEAVAALRARGFKAARLEDGFPEWKAAGFVVETEPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IG9</accession>
    <name>Q63IG9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004524806.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112103.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2104"/>
    <dbReference type="EnsemblBacteria" id="CAH39584">
        <property type="protein sequence ID" value="CAH39584"/>
        <property type="gene ID" value="BPSS2104"/>
    </dbReference>
    <dbReference type="GeneID" id="56531801"/>
    <dbReference type="KEGG" id="bps:BPSS2104"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5648"/>
    <dbReference type="eggNOG" id="COG3523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GRQPING"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009612">
        <property type="entry name" value="IcmF-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010623">
        <property type="entry name" value="IcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017731">
        <property type="entry name" value="TssM1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06761">
        <property type="entry name" value="IcmF-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06744">
        <property type="entry name" value="IcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03348">
        <property type="entry name" value="VI_IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="4">
        <location>
            <begin position="217"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related" evidence="3">
        <location>
            <begin position="527"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF_C" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="1209" mass="132158" checksum="8033814114BF7AED" modified="2004-10-25" version="1">MSHAVARIVRPLPSRDIWTFAGLVVLACFVWLAGPLFAFAEFRPFESGAVRAATIVALFVAWGARIAWRGWRAGQLNAQLLNQLREAAPRPAATGDPAQAQLDELRSRFDEAATLLKKVRFGEADGARKGLPRWLEQMSRQYLYQLPWYVFIGAPGSGKTTALVNSGLSFPLAEQFGRAAIRGVGGTRHCDWWFTNDAVLIDTAGRYTTHESNRALDEAEWKGFVDLLKKYRARQPLNGAMLTISVADLLGASEAERTQHAMVLRKRLLELRAQLGIRFPVYLLVTKADLLAGFAEYFGGFGRAECAQVWGFTFPLAESEAPGFELRAAFDREYRLLHQRLNDGLPELLASQTDARQREMTYLLPQQIADLQDMLGQFVAEVFSVSSFEPMPMLRGVYLTSGTQEGTAFDRVMSGIKRFLKIEGVPPAAQTGSSGRSFFLKSLLQDHIFREAALAGSNLRWHQRQRALQIVGYAAIALLCVAVLFAWLRSYSRNRDYLDEVAARVPAVDAQIGRAKFTGAADIVQLLPVLDELSGLPNAGGVDLRHPPLAYRWGLFQGEKIEEASDAVYRRALDDVLLPIAASRMEQALRDARPDEVEYAYAALKAYLMLYDSAHYDPAFVQAVVDLEMERALPADFSSAQRSALRAHLGALFGNRVAVSPFPMNERLVADVRERLRQVPFSQRLYRQLARTLHASTASYDFSVARAVGPDASLVFRRQSGKSLADGVPGLYTRSGYRNVFAPRLPGAIDSYGREEVWVLNLGASEIPNPADAAAWARDIRQLYLNDYIKTWDDYLADIRLQRTSTLAQSIQVARTLSSADSPLTRLMVALARDTPLGDAPGGARNLASRAQDKVDEARNSLAQIFAGQPGGEAGAAAAPPASPEQIVDSHFAGLRAFAPGGGDQAASFDAVLKAIDALYTYLTATDDALRSGAAPPPSDAPARLRAQAGRLPTPVREVLDDLSNVANGSIASVEQRNVAQRAGANVGDFCRQAIAGRYPFARGAARDVAPSDFAQLFAAGGLMDDFFQKNLQTLVDTTAHPWRFNNRNAEADPSAAAMLGSFEKAAVIRDVYFGGGARTAQIKVEIVPLEMDPSISEMLLDVDGQIVRYAHGPQVPTAVQWPGTRGSNQVRLQVTEQSGATGGFTTEGPWALHRLFDRAGVSGGRGPEQMVARFAVDGKPIVLQVTASSVRNPFRLPQMESFTCPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IH5</accession>
    <name>Q63IH5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS2098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004190698.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112097.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2098"/>
    <dbReference type="EnsemblBacteria" id="CAH39578">
        <property type="protein sequence ID" value="CAH39578"/>
        <property type="gene ID" value="BPSS2098"/>
    </dbReference>
    <dbReference type="GeneID" id="56598118"/>
    <dbReference type="KEGG" id="bps:BPSS2098"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5641"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FMKIDGA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="163" mass="17130" checksum="CDEF93508801663D" modified="2004-10-25" version="1">MGVAMFMKVDGVTGESADAQHKGWTDIQSFSWGASQPGAMASGSGGNAGKASFNDLVVAAYMDKGATAIIKNCASGKHLPTVEISACKTGGSQIEFMRVTLQEVLVTSAQIAGVDPGDAADRLMMQYGFQAAKVKKQYWQQNDNGGKGAEVSVGWNIKENTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63IJ6</accession>
    <name>Q63IJ6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">BPSS2073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004557914.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_112076.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS2073"/>
    <dbReference type="EnsemblBacteria" id="CAH39553">
        <property type="protein sequence ID" value="CAH39553"/>
        <property type="gene ID" value="BPSS2073"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS2073"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5618"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PIGWASR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAH39553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="237" mass="25664" checksum="E7EDE0DFB8397ED8" modified="2004-10-25" version="1">MDADFSNDIPSTLTSSVTDAVINLIHETRLVPNDSLPSEGEFAQKLGVGRGVVREAFKALEALGILELAPGKRARVGKLKSHVLAMLMDHAVVTMQVSVQQTLDLRRTLEVRTARLAALRRSETELAAIREAAAAMRQHGNGRESPTEEDIAFHVAIARAAQNPLYALLIEGFRLVIRQTAPISWAVRQSHEERTAVHDMHDAIVDAIARQDAAAAEVAMAAHFDNSVQALISAGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J40</accession>
    <name>Q63J40_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS1876A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111882.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39354">
        <property type="protein sequence ID" value="CAH39354"/>
        <property type="gene ID" value="BPSS1876A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1876A"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="107" mass="11836" checksum="8FEE1420DB0A8E1F" modified="2004-10-25" version="1">MRGRPPRRRQATLAGRVFAAGMPRASPWRSAARAAGAKPRRPPARDPGSTVWSVGDSLSTPMPTSRAAGRPAVQSRTFRASRATRRFSRYRQSRPSISYLNIRANFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J64</accession>
    <name>Q63J64_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533327.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111858.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1854"/>
    <dbReference type="EnsemblBacteria" id="CAH39330">
        <property type="protein sequence ID" value="CAH39330"/>
        <property type="gene ID" value="BPSS1854"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1854"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5307"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ITYNSRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="256" mass="26456" checksum="4C52DB7F5D216EE6" modified="2004-10-25" version="1">MSAPNLFDLSGKIAVVTGGSRGIGAEVAKLLGAFGAHVVVTSRRLDDCRAIADEIVAAGGSAEAAACHIGELEQIDALYASLEGRHGRLDVLVNNAATNPYYGPIVDTDLGAFQKTVDVNIRGYFFMSNRGAKLMGKNGGGSIVNVASVNGVIPGYWQGIYSITKAAVISMTKAFAIECAASGVRCNALLPGLTDTKFASALTQTPEVLKQVLAHVPMRRAAQPTEMAGAVLYLASAASSYTTGTVLNVDGGYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63J77</accession>
    <name>Q63J77_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004525075.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111845.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1841"/>
    <dbReference type="EnsemblBacteria" id="CAH39317">
        <property type="protein sequence ID" value="CAH39317"/>
        <property type="gene ID" value="BPSS1841"/>
    </dbReference>
    <dbReference type="GeneID" id="56529742"/>
    <dbReference type="KEGG" id="bps:BPSS1841"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5290"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYEDTDW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH39317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="422" mass="45633" checksum="BF82171333231CA2" modified="2004-10-25" version="1">MMDAAVHRAIDAVWRIEAARIIAHVARLVRDVGVAEELAQDALVAALEHWPSGGVPDNPGAWLMTAAKRRALDHLRQHALHARKREQIGLDLDALGAHVAPDVADVFEAARDDDIGDDLLRLVFTACHPVLSTDARVALTLRLLGGLTTGEIARAFLTPEPTIAQRIVRAKRTLSAAKVPFEVPRAPERAARLASVLEVIYLVFNEGYSATAGDDWMRPALTDEALRLGRVLAGLAPDESEVHGLVALMEIQASRMHARVDAQGRPVLLLDQDRSRWDPLLIRRGLAALARSEALGGASGPYALQAALAACHARARHADDTDWEQIVALYDALAQVAPSPVVELNRAVAVGMAFGPAAGLEIVDALAADPALARYHWLPSVRGDLLAKLGRRAEAQAEFQRAADMTLNAREREMLLARATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JA2</accession>
    <name>Q63JA2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111820.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1816"/>
    <dbReference type="EnsemblBacteria" id="CAH39292">
        <property type="protein sequence ID" value="CAH39292"/>
        <property type="gene ID" value="BPSS1816"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1816"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6141"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RLWQFEP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="97" mass="10504" checksum="749A9AA317BDCBD7" modified="2004-10-25" version="1">MFAALGDETRLRIVAALCAGTALSIAQITAGTDITRQSVTQHLLVLAQAGLVHDVKVGRERRWSFDPARIDAARAALDAIGRQWDQALLRLRQAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JI2</accession>
    <name>Q63JI2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS1734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205671.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111740.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1734"/>
    <dbReference type="MEROPS" id="S53.001"/>
    <dbReference type="EnsemblBacteria" id="CAH39209">
        <property type="protein sequence ID" value="CAH39209"/>
        <property type="gene ID" value="BPSS1734"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1734"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.6046"/>
    <dbReference type="eggNOG" id="COG4934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HDEMKRM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266508" evidence="8">
        <location>
            <begin position="34"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="222"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH39209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="582" mass="61042" checksum="63219654612EC37C" modified="2004-10-25" version="1">MNRTADFALSLSPLCKRLACVWPLALAAGIAHGATDWVDTHTKAFLNHAQIETLARGANAASLEVASGEATHVVVSLKLRNAEQLKAVARNVNDPHSSQYRQYITSAQFLANYAPTEAQVKQVIAYLRKNGFVDIHVAPNRMLVSARGTAGTVKQAFNTSLVHFEYAGRAGFANASTAQVPRALGDIVGSVLGLQNVARARPLTKIGAIAKPLALASGTATGHYPSEFPALYNATGVPTAANATVGIITIGGVSQALSDLQQFTSANSYPDVSTQTIQTNGSGGNYSDDQEGQGEWDLDSQSIVGAAGGQLGQLIFYMADLDASGNTGLTQAFNQAVSDNAAKVINVSLGWCETDANADGTLSAEEQIFTQAVAQGQTFAVSSGDEGVYECNNRGYPDGSNYTVSWPASSPHVLAIGGTTLYTTSSGAFSNETVWNEGLDGNGKLWATGGGVSTILPNPSWQSGSHRKLPDISFDAAQSTGAYIYNYGQLQQIGGTSLSAPIFTGFWARLLSANGTGLGFPAARFYHSIPTHASLVRYDVTSGNNGYSGYGYKASTGWDYPTGWGSINISNLNQLIQSGGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JJ8</accession>
    <name>Q63JJ8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="7 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">sdhA</name>
        <name evidence="21" type="ordered locus">BPSS1718</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 18">Cell inner membrane</location>
            <topology evidence="4 18">Peripheral membrane protein</topology>
            <orientation evidence="4 18">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="7 18"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009940953.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111724.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1718"/>
    <dbReference type="EnsemblBacteria" id="CAH39192">
        <property type="protein sequence ID" value="CAH39192"/>
        <property type="gene ID" value="BPSS1718"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1718"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5135"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="18" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 18" id="KW-0274">FAD</keyword>
    <keyword evidence="11 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0813">Transport</keyword>
    <keyword evidence="10 18" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="19">
        <location>
            <begin position="14"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="20">
        <location>
            <begin position="464"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="17">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAH39192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="591" mass="64576" checksum="2630E3B9E72C66BC" modified="2004-10-25" version="1">MAAIKTSLPRRKFDVVIVGAGGSGMRASLQLSRAGLSVCVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVAAKTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARSGIALQDMEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLSHIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGANRLGTNSLLDLVVFGRAAGNHIVEHVKNQRDHKPLPAAAADFSLSRLAKLEKSTSGEYTQDIANDIRATMQKHAGVFRTSALLKEGVEQMAGLKERAAAVHLKDKSKVFNTARVEALELANLIEVARATMVSAEARKESRGAHAHSDYEHRDDENWLRHTLWYSEGDRLDYKPVQMKPLTVESVPPKARTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ3</accession>
    <name>Q63JQ3_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">selA</name>
        <name evidence="8" type="ordered locus">BPSS1663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187099.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111669.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1663"/>
    <dbReference type="EnsemblBacteria" id="CAH39137">
        <property type="protein sequence ID" value="CAH39137"/>
        <property type="gene ID" value="BPSS1663"/>
    </dbReference>
    <dbReference type="GeneID" id="56598016"/>
    <dbReference type="KEGG" id="bps:BPSS1663"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5062"/>
    <dbReference type="eggNOG" id="COG1921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GATNRTH"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="7">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH39137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="480" mass="50936" checksum="F2BD3AE501A62531" modified="2004-10-25" version="1">MSGPGASELNALLARAPSVERVLSSEEMQPLVDEYGRTRALAAVRASLAAWRDAARRDPAAAGTPDDARIAADVRARLAADAAAAMRAVFNLTGTVLHTNLGRALLPDDAVRAVVQALTQPMNLEFDLATGRRGDRDDLIGALACELTGAEAATVVNNNAAAVLLVLSALAPRREVVVSRGELVEIGGAFRIPDIMSRAGAKLREVGTTNRTHLADYADAIGPRTALLMKVHCSNYAISGFTKEVALRELAPLARERGVPVAVDLGSGTLVDLTRWGLPKETTVRETVEAGADLVTFSGDKLLGGPQAGLIVGRRDLIAKIKKHPLKRALRVGKLTLAALEPVLRLYQTPEFLRERLTTLRLLTRAQADIAATAERVRPALQRALGAAFAVDVEPMFSQIGSGALPVDQLPSYGLVVRASGGKRRGRALAQLDAHLRGWPRPVLGRIADDALRLDLRCLEAGDEAAFIAQCAQAPTGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ6</accession>
    <name>Q63JQ6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2778 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551969.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111666.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1660"/>
    <dbReference type="EnsemblBacteria" id="CAH39134">
        <property type="protein sequence ID" value="CAH39134"/>
        <property type="gene ID" value="BPSS1660"/>
    </dbReference>
    <dbReference type="GeneID" id="56598012"/>
    <dbReference type="KEGG" id="bps:BPSS1660"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.5058"/>
    <dbReference type="eggNOG" id="ENOG5032SJM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DHAAWFA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021225">
        <property type="entry name" value="Tlde1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10908">
        <property type="entry name" value="DUF2778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2778" evidence="1">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH39134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="160" mass="17535" checksum="1C6BF7BF5917FE7D" modified="2004-10-25" version="1">MPIRCTFVLNNQSTSAFHCPTVGTLPAFSGRGSGRDNPEATAIEKIGPIPKGIYYIVDRQSGGNLGWLYDLWGQLGYGTSDHTKWFMLWNRDTGDSTYVGKVKRGAFRLHPIGPMGLSEGCITVTNTARFERFAAFLRQKGADLTVPGTNLKAYGTVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JQ8</accession>
    <name>Q63JQ8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111664.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH39132">
        <property type="protein sequence ID" value="CAH39132"/>
        <property type="gene ID" value="BPSS1658"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1658"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5948"/>
    <dbReference type="OMA" id="GTRHGWR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="194" mass="21533" checksum="B1B113026A8CDCDA" modified="2004-10-25" version="1">MARLRRVGTRHGWRRPSGTTAVIIIKKGVRIMATTAEEDVLLHILHNVYSVTGGEVTPSSVSVPTVELKLQFDDNTHRISGFGRIAWGKNKPPKVTSEFVDLLIHGDFGYFPPARKQRDANFPVKTLQINLVGYPNLHWNPRWGIGPQLPIIFHQNAVIPVGSQTGYAAYSYGVPSDPESEISVTDATIRQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63JX4</accession>
    <name>Q63JX4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH39065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205647.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111598.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1590"/>
    <dbReference type="EnsemblBacteria" id="CAH39065">
        <property type="protein sequence ID" value="CAH39065"/>
        <property type="gene ID" value="BPSS1590"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1590"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4971"/>
    <dbReference type="eggNOG" id="ENOG50316XF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MANIGHS"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH39065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="76" mass="8501" checksum="5B569D76B46FDD47" modified="2004-10-25" version="1">MPSIPHSREAEAAQRFFEATRNVELAFRAVRGDAEAPAPSIEYAAAVSRLDRALDELARAQAWFDSAVRMRALKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63K75</accession>
    <name>Q63K75_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS1490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004206324.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111497.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38963">
        <property type="protein sequence ID" value="CAH38963"/>
        <property type="gene ID" value="BPSS1490"/>
    </dbReference>
    <dbReference type="GeneID" id="56597742"/>
    <dbReference type="KEGG" id="bps:BPSS1490"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4835"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DTRHPAQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266357" evidence="2">
        <location>
            <begin position="41"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="341" mass="37048" checksum="F176C208CFCC5678" modified="2004-10-25" version="1">MSQSRQTRRDDIANAKRRRFIARASACTAGALASPYAAHAARAAGGKPRDASGAQDVAIDASIASPNQDSRVRTLVLHYTAQTLARSVALLTDPARPVSAHYLVPDAADAGTLFRVYALVPETNRAWHAGVSYWQGERLLNASSIGVEIVNTGFPDADENAPLMRRRWAPFPDAQMAVVGRLAADIAARHEIPPQKVVGHSDIAPGRKLDPGPLFPWRMLHEQYGVGAWPDAIAVEYYRACRPFRGDIAELQAKLLAYGYDTPQTGVLDLRTTDVIAAFQMHFRPARYDGVPDAETVAILDALLDKYIERDRQRLRDGQAALPEKDDRAPAAGSAAAKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KJ3</accession>
    <name>Q63KJ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sarcosine oxidase delta subunit</fullName>
            <ecNumber evidence="1">1.5.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">soxD</name>
        <name evidence="1" type="ordered locus">BPSS1368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.3.1" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111379.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1368"/>
    <dbReference type="EnsemblBacteria" id="CAH38840">
        <property type="protein sequence ID" value="CAH38840"/>
        <property type="gene ID" value="BPSS1368"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1368"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5594"/>
    <dbReference type="eggNOG" id="COG4311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EIEFRCG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006279">
        <property type="entry name" value="SoxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038561">
        <property type="entry name" value="SoxD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04267">
        <property type="entry name" value="SoxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="96" mass="11129" checksum="D5D8DCD1D542677A" modified="2004-10-25" version="1">MLIECPWCGPRAESEFSCGGEADIARPLDTDKLSDREWGDYVFMRKNPRGKHREQWLHTQGCRRWFVAQRDTVTYEFQGYETFGTPAAHAAKDTSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KP6</accession>
    <name>SYI2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoleucine--tRNA ligase 2</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Isoleucyl-tRNA synthetase 2</fullName>
            <shortName evidence="1">IleRS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ileS2</name>
        <name type="ordered locus">BPSS1315</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205587.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111325.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63KP6"/>
    <dbReference type="SMR" id="Q63KP6"/>
    <dbReference type="STRING" id="272560.BPSS1315"/>
    <dbReference type="EnsemblBacteria" id="CAH38786">
        <property type="protein sequence ID" value="CAH38786"/>
        <property type="gene ID" value="BPSS1315"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1315"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4610"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PSWYIRT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000098371" description="Isoleucine--tRNA ligase 2">
        <location>
            <begin position="1"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="639"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="925"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="945"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="967" mass="106516" checksum="91B4CC91BDD79B7E" modified="2004-10-25" version="1">MSEYKETLNLLQTPFPMKGDLPRREPALVERWAAQRVYARMRAAAAGRPPFVLHDGPPYANGDIHIGHAVNKVLKDIVLKSRFAAGYDAQWIPGWDCHGMPIEHRIEQLHGRGLPPEAVQRLCREYAFEQTERQRRDFLRLGLLGDWPHAFRTMDFRTEANELRFLERIRARGLLYRGQKPVNWCVDCQSALAEAELEYARKTSVAIHAGLRVRDPVDFASRFRRRPVLDKPAMLVVWTTTPWTIPGNAAAGVRADAPYGLYDTPGALIVVAQPLADALFASLGVDHALCALARGRELVGLALGQPFFAGRDVPVVEAEFVTLDAGTGIVHLAPAHGAEDAELCRRLGIAGENVVDGAGRFAADLPEIGGLPLADGIARIVAKLRADGTLVREAAFEHAYPHCWRHKTPILFRSTPQWFIGMDIECEQGEADPGRADVTEEAGATGEARKVGKAEEAEEAGPVKTLRASARDAIADVPFYPPSARQRMEAMIDGRPDWCVSRQRTWGVPLPYFVRRDDRSLHPRSARLVEAVAARVERDGIAAWSRLRPAELGVDENAYEKLSDTLDVWFDSGSIHATVYRDAARADTGGYPADLYLEGADQHRGWFGASLMTGCAADGRAPFRAILTHGFVVDGAGRKMSKSLGNTVSPQRIADTRGADILRLWIASTDYAAEMSISDEILERVVETYRRMRNTLRFLLQNVADFDPRDDAVPAGQLLDVDRYALARCREFVDACRSAYARYDFLAVTRLAHGYCAEELGGFYLDALKDRLYASVADGVERRAAQTALHSVLANLLISIAPILSFTAEEAWTVFAGDERDSVFLHTWDEHAPPPDDAALARWAHVRALRPHVTKALEEARGAALIGRSSEAELVVRAPRDVLDALAPLHGELAAVFIVAGVTLETADQIAVAVARTPLARCERCWRHEPSVAAHASGDALCARCRHALSRRARAERSEPRAAVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KQ0</accession>
    <name>Q63KQ0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BPSS1311A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184396.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111321.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1311A"/>
    <dbReference type="EnsemblBacteria" id="CAH38782">
        <property type="protein sequence ID" value="CAH38782"/>
        <property type="gene ID" value="BPSS1311A"/>
    </dbReference>
    <dbReference type="GeneID" id="56597514"/>
    <dbReference type="KEGG" id="bps:BPSS1311A"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4604"/>
    <dbReference type="eggNOG" id="ENOG5033NYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GCAWQAI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="111" mass="11167" checksum="A6AC368626B7006D" modified="2004-10-25" version="1">MTVPATLAAAGTPPLAEWIGLGTLALLYLFGLGWAVRGAASRARGRAYWIACAALIVGGTACALVAPPSPPDSGEMPPGFGLGVLVTLLGIAGTTAGCAWRAIARLRRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KR9</accession>
    <name>Q63KR9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS1293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111302.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1293"/>
    <dbReference type="EnsemblBacteria" id="CAH38763">
        <property type="protein sequence ID" value="CAH38763"/>
        <property type="gene ID" value="BPSS1293"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1293"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5499"/>
    <dbReference type="eggNOG" id="ENOG5032WZX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DALQCDP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266535" evidence="2">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="200" mass="21908" checksum="CB1C2F76EED45757" modified="2004-10-25" version="1">MILRMRRAPPIPILFAVACVAARAAGLPTPVLSRLPPGYEVMAARQGPDVDAGRISYLIVLHRPADSASEPSPRPLVIVEQQADGTFRLAARNDEVVLRANEGGQCDPFDPQDADENGLAVKGRFFTVQNFVACGQHWSDYVTFRHDARTGRWLFANESAPSRSRSKASRTACARSGPIRESRWRSMHGAAATKRRLSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q63KY6</accession>
    <name>Q63KY6_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004197712.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111235.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1227"/>
    <dbReference type="EnsemblBacteria" id="CAH38694">
        <property type="protein sequence ID" value="CAH38694"/>
        <property type="gene ID" value="BPSS1227"/>
    </dbReference>
    <dbReference type="GeneID" id="56597446"/>
    <dbReference type="KEGG" id="bps:BPSS1227"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4473"/>
    <dbReference type="eggNOG" id="COG3865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVEFELF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="157" mass="17091" checksum="DAB614AA7F8C9C91" modified="2004-10-25" version="1">MAIQKITPFLWYSTQAEEAAAFYAGVFPDSRVARVTAVPGTGSTKLVEFVLFGQPFFAMSHPRTESFNHAISFLVSCRDQAELDRYWSALLEGGGSPDDCGWLRDRFGVSWQIVPDDLIAMMADPDPVKAARVAGAMMSMRKFDVAALRAAYAGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LC6</accession>
    <name>Q63LC6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage-acquired protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205532.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111095.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1083"/>
    <dbReference type="EnsemblBacteria" id="CAH38550">
        <property type="protein sequence ID" value="CAH38550"/>
        <property type="gene ID" value="BPSS1083"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1083"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4281"/>
    <dbReference type="eggNOG" id="ENOG50339P5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RICYRTD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003458">
        <property type="entry name" value="Phage_T4_Gp38_tail_assem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02413">
        <property type="entry name" value="Caudo_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="223" mass="24427" checksum="2D2E89239B699C74" modified="2004-10-25" version="1">MLIHHYDPATGEYLSSGQPDADPRNDGRWLIPASATLDAPPARTPTTWPFYRDGAWFLLPDYRGRLCYRTDTGEPVEIAIAGKTPADLGLTTEPRPSERHAWLDGAWTVPAELLAREKRDAAMAEFERRLAIARRENLGKADAYAAGQLDDEQTYYFKAWSAYQMALVAAIQKDTFPDAIAWPDTPAPYVPPPPEPVAPEGMPPAAPAAAGDAARPEPEYAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LD4</accession>
    <name>Q63LD4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage tail completion protein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS1075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531055.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111087.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1075"/>
    <dbReference type="EnsemblBacteria" id="CAH38542">
        <property type="protein sequence ID" value="CAH38542"/>
        <property type="gene ID" value="BPSS1075"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1075"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.4273"/>
    <dbReference type="eggNOG" id="COG5005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RYIKNES"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006522">
        <property type="entry name" value="Phage_virion_morphogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05069">
        <property type="entry name" value="Phage_tail_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01635">
        <property type="entry name" value="tail_comp_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="155" mass="17580" checksum="C902DB3A0BDAF0CA" modified="2004-10-25" version="1">MTDDLQALERWAGGLLAKLSPAARRQLLRELGRDLRRAQQSRVAAQRNPDGSAYEPRKVKAGGKRLREKAGRVKREAMFRKLRTARYLRIDVDSTGLAIGFDERLSRIARVHQEGQKAPVEPGGPLAQYPVRVVLGFSDADRELVRDRLLRELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LL0</accession>
    <name>Q63LL0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/hydrogen exchanger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS1005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205497.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111011.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS1005"/>
    <dbReference type="EnsemblBacteria" id="CAH38466">
        <property type="protein sequence ID" value="CAH38466"/>
        <property type="gene ID" value="BPSS1005"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS1005"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7330"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="ATHHVAR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="15"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="43017" checksum="BAC06B1DC7DB5161" modified="2004-10-25" version="1">MNSIFVFLSQALLIVAVPPLLMNYLRVGAVVPLVVVQIVFGVVIGPSGLGRLSPETYTALFPPDSLTFLSHVSAIALFFFAIVTGLHLDATALRGHGRKLGFISTASMLAPMSLGVLAGIAISARYPQALDPHASVAEFVAGIGICCGVTALPVLAAILRETNLTSRRLGQFSLALAAVNDGMLWILLAAFLSVTGANAANGGRLFITSALIVLYFVSILFVVRPLLLVLANRLRTSVDTQILIACAVAVASAAATDRLGLHYLLGAFIAGAIIPGAWRDALLERMQPVTVNVLTPFFFISTGLRVLIDVDAPGFLQITLIITLCTAIGKIAGTTLAARMTGESWGFCLGLGFLAQAKGLMELVVATILLDSHVISRTVFSALILMALISTAFAMPLLRLKPVRGAALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LL9</accession>
    <name>Q63LL9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske iron-sulphur domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184731.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_111002.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0996"/>
    <dbReference type="EnsemblBacteria" id="CAH38457">
        <property type="protein sequence ID" value="CAH38457"/>
        <property type="gene ID" value="BPSS0996"/>
    </dbReference>
    <dbReference type="GeneID" id="56597364"/>
    <dbReference type="KEGG" id="bps:BPSS0996"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7320"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AVYQMRR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="334" mass="37555" checksum="A600F59AA81F1BB3" modified="2004-10-25" version="1">MNGTQRFPMDIPFGWFCIGYSDEVAVGDVKPLRYFGKDLVMFRGESGEIGVLDAYCPHLGAHMGHGGTVEGDSLRCPFHHWAYRKDGFCTSIPYAKEMPLIAKREPIAVPYPVVERNGAIWVWHHPQQIAPTYEVLEHEEFVAPGWSKPVRRFWSFASNPQEIAENGVDTAHFKCIHHMDAMPEGEVTYEGHIRRSRTTGETSMIFPDGVTRTVETGTNVINSGAGQKISRFTGFVTISLMEMATPVEADQVELRFCFAFPECPEGSPEWQGAMNTIDYFSGQLGIEGGDIPIWSHKIHREKPILCDGDGAIMRFRRYFEQFYAPRVVPVTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LM4</accession>
    <name>Q63LM4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004199175.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110997.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38451">
        <property type="protein sequence ID" value="CAH38451"/>
        <property type="gene ID" value="BPSS0989"/>
    </dbReference>
    <dbReference type="GeneID" id="56530555"/>
    <dbReference type="KEGG" id="bps:BPSS0989"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7313"/>
    <dbReference type="eggNOG" id="ENOG5034BND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IATSRPW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="180" mass="19387" checksum="CBF227B34CBD2301" modified="2004-10-25" version="1">MFPTLHLPTYVYVLFCAFVYIGVKRCFARQVTPLLPLLSPIGFAMLGATSLHARFPRAGVGADAAALASLAAGAALGWLHASRWRLRFGVEHSRLVVRLPGDASLLVTLLLTFAAETYMHYAVAAAKPWAATHAFALLSFAAWGLLVGMPLGRAINVVARCVRYTNGPRDKDGAYTLDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LU2</accession>
    <name>Q63LU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110929.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0920"/>
    <dbReference type="EnsemblBacteria" id="CAH38383">
        <property type="protein sequence ID" value="CAH38383"/>
        <property type="gene ID" value="BPSS0920"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0920"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.5023"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HVRKSMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="311" mass="33620" checksum="A20336639038FE2F" modified="2004-10-25" version="1">MLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTEAGELLVQHARRALMDGDAVLAEISEIHALGLGIVRIGSTEGFTRCFLPSVMATHYRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEYSVKAPVCALLPPTHPLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAALTGTITLGSQVALEGNPGPPTLVAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQGASAARARRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LW4</accession>
    <name>Q63LW4_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110907.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0898"/>
    <dbReference type="EnsemblBacteria" id="CAH38360">
        <property type="protein sequence ID" value="CAH38360"/>
        <property type="gene ID" value="BPSS0898"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0898"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4995"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="KYDWDAL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="3">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="180" mass="20177" checksum="55313884A72B3F2F" modified="2004-10-25" version="1">MKEMTMADADIERKSWDQPAGESFAQWMDGRVARFETRRYDWDALKFQADFDPKYRRAQMRYVGTGGTGVAKDANTVPAGGFTFSTMVIPAGNVGPSHIHIDVEEIFFVLRGRMKVICERDGETWEAVLGERDLISVPPGVYRTEINVGEEDALMCVMLGSPKPITPTYPPDSPLAKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LX1</accession>
    <name>Q63LX1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II) oxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004543360.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110900.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0891"/>
    <dbReference type="EnsemblBacteria" id="CAH38353">
        <property type="protein sequence ID" value="CAH38353"/>
        <property type="gene ID" value="BPSS0891"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0891"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7184"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRTWEHC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="208" mass="23854" checksum="9B6A0F2CC44720E7" modified="2004-10-25" version="1">MDDLFDDLPRPDADWHPDWLAPADADRFHARLVDEVAWRQDTMRTPRGLLPLPRLTAWQGEPDALYVYSGIRNEPAPWTPAVLELKRRVEAASRARFNSVLLNRYRNGFDSMGWHADDEPELGAEPVIASLSLGATRVFDLRHNETGVTHAYRLTNGSLLVMRGRTQHAWRHRVPKEPAVRGERINLTFRWVSAPPVAERRARPRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LY9</accession>
    <name>Q63LY9_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative porin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939908.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110882.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0873"/>
    <dbReference type="EnsemblBacteria" id="CAH38335">
        <property type="protein sequence ID" value="CAH38335"/>
        <property type="gene ID" value="BPSS0873"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0873"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7164"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NNWATPY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00342">
        <property type="entry name" value="gram_neg_porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033900">
        <property type="entry name" value="Gram_neg_porin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002299">
        <property type="entry name" value="Porin_Neis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13609">
        <property type="entry name" value="Porin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00184">
        <property type="entry name" value="NEISSPPORIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0626">Porin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267363" evidence="5">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Porin_4" evidence="6">
        <location>
            <begin position="11"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="400" mass="41661" checksum="D0E1742C7D0D57A1" modified="2004-10-25" version="1">MHIRTWIAAGVAGAAVVPACAQSGVTLYGTVDTGVIYSTNQQVTHADGSTSGGHAWQMDGGNLVPSRWGLQGTEALGGGLKAVFALEQQFLSASGQALQGGVAFSRQAWVGLRHDRYGTLGVGRQYDSYTDTLGAYVSSNSWATPYGSHLGDVDNLNAAFNFNNAIRFTSADFHGLTFGGTFGFGGQAGDFSARRGYALAVAYNRAPVSFGIGYLNLRQPLDAALGGANGYIGDFACGNAGAMYCLLQDAVSMKAFGVGGSIAFGEATVALTYTHTRLGDSAYFAAAARAQSASIAFDIAELNATYAFTPMLRGGIAYVFNRAKADSRGVTRFHQLNVGVNYSLSKRTALYAVAIGQIASGRGLGSDANGDPVNYAQIPVLANSNSNRQLAMMAGVKVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63LZ1</accession>
    <name>Q63LZ1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011205480.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110880.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0871"/>
    <dbReference type="EnsemblBacteria" id="CAH38333">
        <property type="protein sequence ID" value="CAH38333"/>
        <property type="gene ID" value="BPSS0871"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0871"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7162"/>
    <dbReference type="eggNOG" id="ENOG5032T4A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WARWYER"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021500">
        <property type="entry name" value="DUF3156"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11354">
        <property type="entry name" value="DUF3156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH38333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="206" mass="21604" checksum="738DD2923C5813CF" modified="2004-10-25" version="1">MSGRASAIVRAAAIAGWRRRFAPAAAPGYRCGATLARVAADLGATLAAADGGDARRMAFDDGVEWRAIERVDRQFLLHTVSVQLERTIAGPAAHGSASIAASGWVRRGPLAAAITRNADARFGALVPTLLAAPALNAPLAALDLTYCAIVACGSRWTLRIVPFGGSEVAGRMPPFRRYVRLADTQRDALRAAFAGFEAALARMPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M03</accession>
    <name>Q63M03_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110868.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0856"/>
    <dbReference type="EnsemblBacteria" id="CAH38319">
        <property type="protein sequence ID" value="CAH38319"/>
        <property type="gene ID" value="BPSS0856"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0856"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7143"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QVNPVNE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="173"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="755" mass="82880" checksum="DC646264990DA7C7" modified="2004-10-25" version="1">MSYVVAVRAMCEFTARAGDLDLRFTPAPSALEGIAGHATVVSRRGTGYEKEIALSGEHRGLTVRGRADGYDPALNRLEEIKTHRGDLDRMPANQRALHWAQARVYGHLLCESRGLAELSVALVYFDVGTLRETVLTETHTAATLKAGFVEQCERFADWAAREDAHRAARDAALRALAFPHARFRSGQRELAVAAYRAARDGRVLLAQAPTGIGKTLGALFPLLKACGQAHLDRLFFLTAKTPGRALALDAADTLRAAAGGVLPLRVLELVARDKACEHPDAACHGESCPLARGFYDRLAAARAAALEHGRLDRAAVRAAALAHDVCPYYLAQELARWCDVVVGDYNYYYDGSALLHALTLQNQWRVGVLVDEAHNLLDRARGMYSAALDQRELAGVRKLAPAPLAKALERLNREWNALNREQAGAYVVHPDVPQRVLSAAQNLIGCFSEFAAQAPLALDDAVLRFCFDAIHFVALAEQFGTHSIFDATRVRAGAPRRGGHASILCVRNVIPADFLAPRHGAARATVMFSGTLSPFDFYRDTLGLPGDTGTLDVEGPFRAEQLTVKVASHVSTRWRDRERSLEPIVELIAEQYAARPGNYLGFLSSFEYLQQVVARLRERHPALPVWEQAPGMDEAARDAFLARFEPNGRGIGFAVLGGAFSEGVDLAGDRLIGAFVATLGLPQVNGVNEEMRRAMDARFGSGYDYIYLFPGLRKVVQAAGRVIRTEHDEGVLHLIDDRFHRGEVRRLLPRWWRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M08</accession>
    <name>Q63M08_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nitrilotriacetate monooxygenase component A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004551559.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110863.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0851"/>
    <dbReference type="EnsemblBacteria" id="CAH38314">
        <property type="protein sequence ID" value="CAH38314"/>
        <property type="gene ID" value="BPSS0851"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0851"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7137"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="RMLGNFD"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="223"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="448" mass="47876" checksum="209DC7CA3E5A7EE2" modified="2004-10-25" version="1">MTSLPKRPQRRQLHLNVNILHSGFAPSAWRIDDADPRAFVDVSHYVRIARIAEAAKFDAVFLADNASIVDQIDFRPITALESTIVLASIAAATARIGLIGTASTSYNEPFNLARRFASLDHVSGGRAGWNVVTTADAGSARNFGLDAAPDHAARYARAAEFVDVVKALWDSWDDDALVGDKASGRFVDTAKVRPIAHRGTHFRVHGPLNLPRPPQGHPVLVQAGGSADGRAFAARHAQAVFSASQSFDEALAFARALKAAAAGCGRGDIMVLPGLTTIVGATEADALRRRDELVDLIPLRYGLNRLAGTLGVPVERLAPDAPLPDDLALPDGGNGNHTFFHATLARARRRGYTARELIRAMAGGGGHRVIAGTPEQIADDIARWFGAGAADGFNLMPDVLPGGLRDFVDGVVPILQRRGLFRTEYEGTTLRDHFGLPRPAKPGACERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63M18</accession>
    <name>Q63M18_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">BPSS0842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004200944.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110853.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0842"/>
    <dbReference type="EnsemblBacteria" id="CAH38304">
        <property type="protein sequence ID" value="CAH38304"/>
        <property type="gene ID" value="BPSS0842"/>
    </dbReference>
    <dbReference type="GeneID" id="56597168"/>
    <dbReference type="KEGG" id="bps:BPSS0842"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.7120"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH38304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="402" mass="41596" checksum="6FCA16BE0F4B18EA" modified="2004-10-25" version="1">MPARSASSPRPPIPRTVWALGFVSLCMDVSSELIHALLPIYLVTTMGMSVAALGVLEGAAEATAMIVKIFSGALSDWLGRRKALLLLGYGLAALTKPLFPLAAGPATVAAARLLDRVGKGIRGAPRDALVADVAPPEIRGACFGLRQSMDTVGAFAGPLLAIALMLAFADHIRAVLWFAVVPAFAAVALILFGVEEPASAPAAARAFRSPLHWRALRAFSGRYWFVVLIGTAFTLARFSEAFLVLRAQQVGLDIAWIPAVMVVMSVAYAASAYPVGIVSDKFGARAPLAAGMLLLIAADLLLGASASRTALFAGVAVWGLHMGFTQGMLAALVAQTAPAALRGTAFGVFNLAGGIAMLAASALAGWLWEHHGAPTTFFTGAALAAVALAMCGFVRRRPGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MF7</accession>
    <name>Q63MF7_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004557395.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110714.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH38160">
        <property type="protein sequence ID" value="CAH38160"/>
        <property type="gene ID" value="BPSS0700"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0700"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6915"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPGMSSW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH38160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="321" mass="32883" checksum="3D79B421AEAB14D9" modified="2004-10-25" version="1">MKAAVVHRAGERPTYAEFEPPRALPGHRLIDVSASALSRLAQARASGAHYSSTGGFPFVAGVDGVGRLDDGRRVYFFGPPAPFGALAERTLVPAAQCIPLPDSIDDATAAAIAIPGMSSWAALTERARLAAGETVLVNGATGASGRLAVRIAKHLGAASVIATGRNAHALDALSSAGADATISLAQDDEQVARAFEAHFRAGVDVVLDYLWGASARAALLAAAKAPQQARPVRFVQIGTIGGAELPLPGAVLRASAITLMGSGLGSIALPRLLNAARAVLGAACEARLRIDTRTVPLADVDAHWGDTGSTLRPVFTMRAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MJ0</accession>
    <name>Q63MJ0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">BPSS0666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004538997.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110681.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0666"/>
    <dbReference type="EnsemblBacteria" id="CAH38125">
        <property type="protein sequence ID" value="CAH38125"/>
        <property type="gene ID" value="BPSS0666"/>
    </dbReference>
    <dbReference type="GeneID" id="56530883"/>
    <dbReference type="KEGG" id="bps:BPSS0666"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6870"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PTIWWIE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M9_N" evidence="12">
        <location>
            <begin position="95"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAH38125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="645" mass="72824" checksum="47249FE59CF100F8" modified="2004-10-25" version="1">MKNSHNVVNRFIVAASIIIGVVLYSSAWANPQPMHTKQARMPRIPQNLPLSPDQAKYDLPLSKYDRATLMEPLRRKQSAKPDRRTRPGADCRDMSIMTQYHGTALADYIANLPDYECHYGLFSIDRAMAAQIFNSENVWAVASRLTQEINRYDATNITLVNLLIYLRAAYFQYDAAQLADPIPGLVVWLRPYILQSLSGDALYLENSRAPSTANELMILITNMKDEAYYLPTLKDRIAFYTASATNPQAAAPLLQRSAAGGFTGLLTVFFYAHQRSGAQPMLDSDATLPETLNRFVTANRAYLSNTSAAYQLADAARETYRFLRYPSQKPRVKKMIQDMLASTTMTGPDNDLWLAAAEAADYGDPGNCADYGTCDYQKRLIEAVLTHRYSCNANVRILAQDMTVPQFQSACQSVAQEEDYFHRMMKTGHVPVANDHNDTIEIVVFGDYDNYRKYASVIYGISTDNGGMYVEGDPSAPGNQARFIAHEASWLRPEFKVWNLEHEFTHYLDGRYDMAGDFAASTAKPTVWWIEGLAEYISRKNDDQESIDAVRTNAYRLSDVLQTTYSSGDYVTRAYRWGYMATRFMFERHRADVDAIVSRFRVGDYDGYADYVAYMGNRYDSEFVDWARGATTTGEPPLPPTKAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MM0</accession>
    <name>Q63MM0_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004184573.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110651.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0630"/>
    <dbReference type="EnsemblBacteria" id="CAH38087">
        <property type="protein sequence ID" value="CAH38087"/>
        <property type="gene ID" value="BPSS0630"/>
    </dbReference>
    <dbReference type="GeneID" id="56597685"/>
    <dbReference type="KEGG" id="bps:BPSS0630"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6816"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QIISEVW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH38087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="236" mass="26700" checksum="28BD45DC12BA4B54" modified="2004-10-25" version="1">MSFRILLVEDDNRLSTLIAGYLRKHEYLVDTVLNGDDAVDAILTGRPDLVILDVNLPGKDGFEICREAREHYDGVIIMVTARDEPFDELLGLEFGADDYVHKPVEPRILLARIKAQLRRAPVRQADGALAQPESYTFGKFTIDRANRTVSLPDGTTPELTSAEFDLLWVLVCHAGEVVSRDDLMLQLRGVEFDGLDRTIDGRISKLRRKLRDDASCPQRIKTIRSKGYQFSKNAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MP1</accession>
    <name>Q63MP1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine pyrophosphate enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110630.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0609"/>
    <dbReference type="EnsemblBacteria" id="CAH38066">
        <property type="protein sequence ID" value="CAH38066"/>
        <property type="gene ID" value="BPSS0609"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0609"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4640"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="EGCAVGM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="241"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH38066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="410" mass="42891" checksum="E93410BBA229630A" modified="2004-10-25" version="1">MTMKTEDLIGILTDAGVDLAVGVPDSLLKSFCGRLNDPDCPLRHLVASSEGGAVGIAIGHHLATGGLAAVYMQNSGIGNAINPLVSLADRAVYGIPLVLIVGWRAEISVSGAQVHDEPQHVTQGRITLPLLDALSIRHLVLERAGGENDALAPSIAQLIASARQTSQPVALVVRKDAFDDASASQPGAAAPHAGRMTREQAIALIVEHADAGAAIVSTTGVASRELYELRDRLGHSHARDFLTVGGMGHASQIAVGIALARPAQKVICIDGDGALLMHMGGLAYCAGAPNLTHVVINNGVHDSVGGQPTLAAHLRLSHIAASCGYAFSRSVATPIELESALHHASRLDGSAFIEVTCRPGYRSDLGRPRTSPAENKRHFMAFLSRNGATHERDDHAQESGIQDAIQCARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MT4</accession>
    <name>Q63MT4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thermolysin metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH38021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004530060.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110585.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0564"/>
    <dbReference type="MEROPS" id="M04.026"/>
    <dbReference type="EnsemblBacteria" id="CAH38021">
        <property type="protein sequence ID" value="CAH38021"/>
        <property type="gene ID" value="BPSS0564"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0564"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6733"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VNVYYHI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004266994" evidence="2">
        <location>
            <begin position="27"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="3">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH38021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="567" mass="59839" checksum="886D5AADE04EA1D7" modified="2004-10-25" version="1">MQTSRKALPLALGLAIGLGAALPAWADSKAPSPQEESRRASLTRGVVAPAEQAGKTGQFRPGAVAVTLASPAFHAKKADAAAMAREYVTARAAQLGLDKAALANLVVASERADAAFTVVRFQQRAAGLPVYDSDIAVTVAPDGRVLYVASKAVSGVAAVSSKTQAVDEQQALDRARAYLGVGGFVNVQSQLVAFVDGAGTHTAWKVSGRPQDSLHGDWELIIDAGSGEVLRAQDKASYATDGSGLVFRPDPLSPTKSSYGSPGFKDNNDADSPQLSAARVRVTLKDLTQTSGGYKLSGPYASCIDFDAPLDKACPVQASTTFDFTRSNLYFEAVNAYYHIDTFLRYVNLTLGIKALPYQYAGGVQYDPHGQSGDDNSSYSPSSGRLSFGQGGVDDAEDADVVIHELGHGIHDWITNGGLSQVEGLSEGTGDYLAAAYSRDFNQWSPSDAQYHWVFNWDGHNEFWAGRVTNYNVGRTYAQIRNAAIHTAGQYWASCNMVARDAIGGAAMDKAFLKGLSMTNGSTNQKAAAQAVLTAAAALGYSSAQLNAIGDAYNKSCTYGVTVPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q63MV6</accession>
    <name>Q63MV6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">BPSS0542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939521.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110563.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0542"/>
    <dbReference type="EnsemblBacteria" id="CAH37999">
        <property type="protein sequence ID" value="CAH37999"/>
        <property type="gene ID" value="BPSS0542"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0542"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4560"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="YKAGSGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267381" evidence="5">
        <location>
            <begin position="32"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="55"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="7">
        <location>
            <begin position="406"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="554" mass="60331" checksum="CD28DF354C2F4CBE" modified="2004-10-25" version="1">MHSMSNPRLRFSSVVYGLIALAACASFAAHASGARCAASPAKSADGTPQWRPALHYTPRRNWMNDPNGLVYENGVYHLFYQYNPHGNFWDDMSWGHATSRDLVHWDEQPVAMPANAREDIFSGSIVADARNTSGLGTPNAPPLVALYTSVYKAGSGHEPGTQAQSLAYSIDHGKTWRPYAHNPVLTLAPESRHFRDPNVTWYAPGGYWMMTAVVADAPVVKLYRSSDLIRWDFLSDFTLPDVPHRGALWEMPELLPMPLDGDAARMKWVMIVNVNPWSIAGGSGAMYFIGEFDGRTFTPDRAAPANADPAQYSWLDHGADYYAAGTFANAPGEGPVAIAWMSNWDYAERIPTTPWKGAMALPRELALKTIDGRPRVTVAPARAFDAFARTRPAVRIGSLAVASATRELGADARGTVQRIAVTIEPRSARRAGLIVRRSANGRVGTRIVYDSSAHTLSVDRSASGETNFSNAFSQRHIVALPLVNGKLRLDVIVDRDSVEVFDGDGRTVITDLVFPSPADNRLAVFAEGGDATFGDVVVTNLDETAGERRGCPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N51</accession>
    <name>Q63N51_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSS0446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004529957.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110468.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0446"/>
    <dbReference type="EnsemblBacteria" id="CAH37902">
        <property type="protein sequence ID" value="CAH37902"/>
        <property type="gene ID" value="BPSS0446"/>
    </dbReference>
    <dbReference type="GeneID" id="56531103"/>
    <dbReference type="KEGG" id="bps:BPSS0446"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6588"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FCCIGTT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="209" mass="22530" checksum="974C68422E8C58DB" modified="2004-10-25" version="1">MKLLLVGSTGLVGRHVLELALADPRVDGVTALARRALPAHPKLHALRVDFDRLPEDAPWWRADAAICTLGTTMRAAGSRPAFRRVDHDYPLEVARIARRHGTPTYVLNSALGADPSSRFFYNRVKGELERDLAGLGFASFTAVRPGLIGGQRDAFRAGERAAVLALTLFGPLLPRGWRLNPAQRIAGALLDAALNPAPGLHVVASDQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63N84</accession>
    <name>Q63N84_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSS0412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0412"/>
    <dbReference type="EnsemblBacteria" id="CAH37867">
        <property type="protein sequence ID" value="CAH37867"/>
        <property type="gene ID" value="BPSS0412"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0412"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4402"/>
    <dbReference type="OMA" id="CQSGMAA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="141" mass="15447" checksum="8ED0904D4FAC03F1" modified="2004-10-25" version="1">MRHRAGFKHHVKRGEHPTATASDREHYAEFGDKMSADDAKHVETESIEAAVFRKAVCAGFDHKRVALALMKRGGRSAANRRTPTCQSGMAADSRNIGEARCARRLCSQSLLFPCPRGALETETLQGQSIVTNCAGGAYQFR</sequence>
</entry>
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    <accession>Q63N99</accession>
    <name>Q63N99_BURPS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BPSS0397A</name>
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        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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            <taxon>Betaproteobacteria</taxon>
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            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110420.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0397A"/>
    <dbReference type="EnsemblBacteria" id="CAH37850">
        <property type="protein sequence ID" value="CAH37850"/>
        <property type="gene ID" value="BPSS0397A"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0397A"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="35" mass="4091" checksum="1610C46924880C9E" modified="2004-10-25" version="1">MKHFVTGALALLILWLVVEVTRAMKHIGRDEHHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NC1</accession>
    <name>Q63NC1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phage integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">BPSS0378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
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            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
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                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110398.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0378"/>
    <dbReference type="EnsemblBacteria" id="CAH37826">
        <property type="protein sequence ID" value="CAH37826"/>
        <property type="gene ID" value="BPSS0378"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0378"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4372"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="AYNRSNY"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="104"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="409" mass="45881" checksum="64E59A6DF45FA171" modified="2004-10-25" version="1">MPESLLRDLQCRSAKPRERVYRLSDGGGLALLVKPNGLKYWQFRYMKPDGREGLIQIGPYPRITLEAARAARNEHRVAVQGGDDPATLRKQEKARRKIDAARALNFKQCATAFIEARSAEWVNPKHAQQWTNTLSTYAYPIIGALRPADIDTDLVRKVLEPIWLTKNETASRVRGRIESVLDWAKVRGLRDGENPARWSGHLDQLLAAPGKVQKPKHHAALPFTEIGAFVAELRGMVGTAARALEFTILTAMRTGEVIGARHDEFDADAQLWTVPAERMKAKRAHRVPLSSSALELLKTLPTSADSPVVFEGMRARRPLSNMAMLQVLERMKRGALTVHGFRSTFRDWAAECTPFSNEVVEMALAHAIRDKTEAAYRRGDLFEKRRTLMQAWADYIEQEVAATLTKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NN6</accession>
    <name>Q63NN6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">BPSS0264</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
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                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004188746.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110283.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0264"/>
    <dbReference type="EnsemblBacteria" id="CAH37710">
        <property type="protein sequence ID" value="CAH37710"/>
        <property type="gene ID" value="BPSS0264"/>
    </dbReference>
    <dbReference type="GeneID" id="56597016"/>
    <dbReference type="KEGG" id="bps:BPSS0264"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6351"/>
    <dbReference type="eggNOG" id="ENOG5030Y1N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="PGRRFCQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021294">
        <property type="entry name" value="DUF2866"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11065">
        <property type="entry name" value="DUF2866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH37710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="86" mass="9718" checksum="AF21E5F052198957" modified="2004-10-25" version="1">MVEDTVFSGLRTLLTHEHAFPVQSCRVSIEMQRPWGRPYRLVEWTMHLDAPARRRIVPAESTEAEIAEAVASHVPGRLYEGGAALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NQ3</accession>
    <name>Q63NQ3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523480.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110266.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0247"/>
    <dbReference type="EnsemblBacteria" id="CAH37693">
        <property type="protein sequence ID" value="CAH37693"/>
        <property type="gene ID" value="BPSS0247"/>
    </dbReference>
    <dbReference type="GeneID" id="56531298"/>
    <dbReference type="KEGG" id="bps:BPSS0247"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6334"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="WGATILP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="282" mass="29981" checksum="CF7790746F5AA4F3" modified="2004-10-25" version="1">MRSSTTAGFAGGIPFRRGKRRPSFGAIVVNGVVALFALYLLMPIVLLLIGSIGQSWTNTLLPAGFTWRWFAELAADPSLRRAFGVSFVVALACCALDTLAGVPLAYALHHRALRGRGVAARVVMLTPIGVPALTLGFGYIVVFGGDALPWLGTLPLMIAAHAVLTLPYLLQTLLSDLRHLDLAKLEACAATLGAPPLRQFFTIVLPNLRQSLFSGLVMVAALSIGEFQVSNLIAGFRYRNFPVVLLQAFYGASGIACAASVVLLLLAVLATLASTHTVQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NU2</accession>
    <name>Q63NU2_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prpC</name>
        <name evidence="8" type="ordered locus">BPSS0207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004187967.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110227.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0207"/>
    <dbReference type="EnsemblBacteria" id="CAH37652">
        <property type="protein sequence ID" value="CAH37652"/>
        <property type="gene ID" value="BPSS0207"/>
    </dbReference>
    <dbReference type="GeneID" id="56596960"/>
    <dbReference type="KEGG" id="bps:BPSS0207"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6277"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NEAVMHM"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAH37652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="390" mass="42956" checksum="62A265B1238DE0A7" modified="2004-10-25" version="1">MSETKEAAATGAAGGFKPKKSVALSGVAAGNTALCTVGKTGNDLHYRGYDILDIAGSSEFEEIAHLLVHETLPNVTELAAYKAKLRAMRGLPANVKAALEWIPASAHPMDVMRTGVSVLGTVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHYSHNGRRIETETDDDSIGGHFLHLLHGKTPSKSWIDAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALRGPKHGGANEVAYEIQNRYRTPDEAQADIRRRVENKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAGDLKLFNIAERLESVMWEIKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTAGWSAHIIEQRVDNKIIRPSANYTGPEDLKFVPIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NY5</accession>
    <name>Q63NY5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnO</name>
        <name evidence="9" type="ordered locus">BPSS0163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523564.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110184.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0163"/>
    <dbReference type="EnsemblBacteria" id="CAH37608">
        <property type="protein sequence ID" value="CAH37608"/>
        <property type="gene ID" value="BPSS0163"/>
    </dbReference>
    <dbReference type="GeneID" id="56531385"/>
    <dbReference type="KEGG" id="bps:BPSS0163"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6223"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LYRPKMG"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="382"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH37608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="622" mass="69153" checksum="B178C7CE153FE320" modified="2004-10-25" version="1">MCGITGWIDFARDLRNEAPIVDTMTDTLARRGPDARGVWLDTHAALGHRRLSIIDPERGAQPMLTPERGPRGLPRAVISYAGETYNFRELRAELGALGHRFDTHCDTEVVLRAYLEWGAAFVDRLNGMYSIAIWDTARDELLLVRDRLGVKPLFYYPTADGVIFGSEPKAILAHPDVRARTSSEGLCDALLFLRTPGQVPFSGMREVKPGHVLRVRRGGLAEQRYWALEARPHTDDLPTTIATIRALLDDIVSRQMISDVPLCALLSGGVDSSTIAALAQKRRRASGGGALSTFCVDFTGHTRNFRADPIRPTADAPFALEVARHIGSDHHTIELDQAGLLDPQVREAVLRAWDLPFNFADLDVSLHRLFAEVRKHATVALSGEAADEIFGGYLWFSDPAARRAHTFPWLKLGAHRGLDPRALFHRSFIDALRLGEYEAQLYRAALAEVPRLDGENAEDRRTRELHYLTLTRWLPVLLDKKDRMGMASGLEGRVPFCDHRLVEYVFNIPWAMKTFSGQEKALLRAAAADLLPESVLNRKKAAYPSIQAPGYDRGLIERLNRAIAAGRAPLEPFIDAGALRGLTEKTAAGSLSEFERILLESSSRLNDWLDLYRVELDGVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q63NY6</accession>
    <name>Q63NY6_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative siderophore biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSS0162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110183.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0162"/>
    <dbReference type="EnsemblBacteria" id="CAH37607">
        <property type="protein sequence ID" value="CAH37607"/>
        <property type="gene ID" value="BPSS0162"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0162"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.4100"/>
    <dbReference type="eggNOG" id="COG2368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPQVNRA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024677">
        <property type="entry name" value="HpaB/PvcC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500125">
        <property type="entry name" value="4_HPA_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="2">
        <location>
            <begin position="282"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000331-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAH37607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="501" mass="55101" checksum="1F4366CB39BC27FD" modified="2004-10-25" version="1">MVQGGTTMTLMTGNDYLDSLRDGRNVYVGGERIADVASHRAFRNAARSIASLYDALHGEHRERLTAPDRHGQITHRFFKPSESPDDLLAAQDAIELWSRMTYGFMGRTPDYKAAFMSGLEAGADYYGDFRQNAAGWYKRFAGSGLYLNHAIINPPLDRGKAIHDMRDVFVRVVGETDRGIVVSGVKMLATAGALTNATFVAPVASALLEPGKADDFAIVFFARMDNPGLSLMCRPSYEAAATSPFDAPLSSRFDENDSVLIFDRALIPWEDVLVYRDVKRATGFYAASGFANLYNFQSGIRLAVKLELMIGLLSLGTQANGTQSFRGIQAALGELVSLQHLLKTITAAMARDPERTPSGVVVPKLQYASALRIQVPQIWKRVRELMETALGGSPLVTVSGAADLLDPRVKGLIDAYYRGAALEPQQRIKLFKLIWDATGSEFGSRHSVYETHYSGNFDQIRLDSLTWATRSGQLADCEAFARQCMGDYDASGWLRGPWLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P08</accession>
    <name>Q63P08_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar ABC transport system, lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">BPSS0140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004531547.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110161.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q63P08"/>
    <dbReference type="STRING" id="272560.BPSS0140"/>
    <dbReference type="EnsemblBacteria" id="CAH37585">
        <property type="protein sequence ID" value="CAH37585"/>
        <property type="gene ID" value="BPSS0140"/>
    </dbReference>
    <dbReference type="GeneID" id="56531411"/>
    <dbReference type="KEGG" id="bps:BPSS0140"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6188"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SVDGGCT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004267406" evidence="1">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH37585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="315" mass="32863" checksum="D9E7BCA9CEF05C4C" modified="2004-10-25" version="1">MLEIKHKLVQTAAACALAFAACAAHAADKPLKSIGITVGSLGNPYFVTVVKGAQAQAKEINPSAKVTAVSADYDLNKQFTQIDNFISAHVDMILLNAADPKAIEPAVRKAQAAGIAVIAVDVAASGADATVQTNNVKAGELACDYLAKKLNGKGNVIIENGPQVSAVVDRVNGCKAVLAKNPGLRLLSSDQDGKGSREGGMNAMQGYLTRFPKVDGLFAINDPQAIGSDLAAKQLRRTGIVITSVDGAPDIETALTSDTQVQASSSQDPFAMAKKAVSVGYGIMNGHKPANAMILLEPTLITRENVKRYKGWSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P32</accession>
    <name>Q63P32_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative chaperone-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">BPSS0116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009939095.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110137.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0116"/>
    <dbReference type="EnsemblBacteria" id="CAH37561">
        <property type="protein sequence ID" value="CAH37561"/>
        <property type="gene ID" value="BPSS0116"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSS0116"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6148"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QRIARHC"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017729">
        <property type="entry name" value="ATPase_T6SS_ClpV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03345">
        <property type="entry name" value="VI_ClpV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAH37561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="881" mass="95259" checksum="6194958250A7370D" modified="2004-10-25" version="1">MTVSRQALFGKLGYSLFRSIESATAFCKLRGNPYVELVHWLHQMLQAADGDMQRIARHCDIDLGELERDMVRALGELPAGASSISDFSHHIETAIERAWVLATLDFGDRRIRGAWLLAALLKTPELRRVLLSISSAFGRIRVDELDAMLPAWIDGSPEANETPYDDSDFGAAIPGEASSAMQQKGGGSPLEQFCLDLTARARAGQIDPVVGRELEIRTMIDVLLRRRQNNPLLTGEAGVGKTAVVEGLARAIAAGDVPPKLADARLLSLDVGALLAGASMKGEFEARLKGVLEAAAKATLPVILFVDEIHTLIGAGGQAGTGDAANLLKPALARGTLRTIGATTWAEYKRHIEKDPALTRRFQVLQVPEPDEAAAIDMVRGLTRTFSRHHGVVVLDEAIRAAVKLSHRYIPSRQLPDKAISLLDTACARVALSQHAPPRELQDVRRRLEAARVRLELLDGEQRIGLGDEAALAQSRAEIAALEVEEQSIDACWRQQIEAAQTLLSAREAAGDAAASAIDALRELEHALSNLQGDHAFVFPEVNEAIVAEIMSDWTGIPVGRMVTDEVSAVRALPDTLAARVIGQRDALHQIGDRVQTARAGLTDPKKPLGVFLLAGPSGVGKTETALALAEALYGGEQNLITINMSEYQEAHTVSGLKGAPPGYVGYGEGGVLTEAVRRRPYSVVLLDEIEKAHPDVHEMFFQVFDKGYMEDGDGRYIDFRNTTILLTSNAGSDLVSGLCMDEACAPDADGLCAALASELLKTFPAAFLGRVTLVPYRPLAQETLSRIVRLHLDRVVTRMAENQGVALRYSDNVVDYVVNRCLVQETGARLLIGFIEQHVLPLLAKLWLDSLASKHVLTRVDLDVADPAAAPTEAFALRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q63P95</accession>
    <name>Q63P95_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSS0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571966">
        <property type="protein sequence ID" value="CAH37493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194481.1">
        <property type="nucleotide sequence ID" value="NZ_CP009537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110074.1">
        <property type="nucleotide sequence ID" value="NC_006351.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSS0050"/>
    <dbReference type="EnsemblBacteria" id="CAH37493">
        <property type="protein sequence ID" value="CAH37493"/>
        <property type="gene ID" value="BPSS0050"/>
    </dbReference>
    <dbReference type="GeneID" id="56596799"/>
    <dbReference type="KEGG" id="bps:BPSS0050"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.6053"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NPKAWIM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="205" mass="22444" checksum="0629B33C0AAB2F36" modified="2004-10-25" version="1">MNYLTLSALPAGMLFALVTSITPGPNNTMLLASGVNFGFRRTLPHMFGISAGVAILMLSVGFGLGEAFKRIPILYTLLETASVVYLLYLAWRIGTSGEVRAHNGKSRPMTFVEAIAFQWVNPKAWMMVLTAATTIQLSADYGRNAVWMALVFVFVGLPCISVWAAFGQGLRGFLSNPRWLRVFNLTMATLLVLSLYPMFAKVSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PG3</accession>
    <name>Q63PG3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_110006.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3413"/>
    <dbReference type="EnsemblBacteria" id="CAH37425">
        <property type="protein sequence ID" value="CAH37425"/>
        <property type="gene ID" value="BPSL3413"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3413"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3882"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TETNSMI"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="411" mass="42460" checksum="FAABF68F7616EB12" modified="2004-10-25" version="1">MSRAQRVRYTRRSPTRWSGNGRARDTETNSMIGAGRFWGIGTANAWAAVSGVAFAEARTDFAACSDAASARFAAPPSLRAKDAIALPPREIDRWATRAVELDDAADSARVPNGAYSHPSENHLDAPIGSAVSTRSSAMGGTAARLPARAMSSMATASGLESFDAKRAFRGFETRPRDLSASAAIARHGFATRDRKTIAPAGLDAACGGSALVQVGGASVVKRIVFAEAGRRVCGDASVGPWASRAPSKWPDAVTPHAGPGARMLGALSLETPAARSACCDAGATCRRAHGAAIEGLRHAHGAGGGGARRPAGLALVVDAFLTDSSFNSLFAPVFRLAYEDAHDAGTTPTTGEHARSAAPLSAHGVRGASNRSRLGMPVFRRASPTWCDGATDVAGVCRVFDRHAGLGEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PN1</accession>
    <name>Q63PN1_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938954.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109938.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH37355">
        <property type="protein sequence ID" value="CAH37355"/>
        <property type="gene ID" value="BPSL3342"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3342"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3802"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MARIIGH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="51"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="520" mass="58320" checksum="E27EBD355228D1B5" modified="2004-10-25" version="1">MTMKYRESQVDKELRQWFAKDMSKALLRRIMLIRGSLRGINSLDISFTYPITAFAGINGAGKSTILALACCAYHANKNGFKLPRRKNPYYTFSDFFIRHKEEAEPDGIEISYAIAYNNWKKTDSFPNGEGVAYQRRKKNKGGKWNDYQARVRKTVVFLGIERIVPHSERSQSRSYSRAFADTVPKGWEDKVREAVGFILSKKYDDLRYLEYSRYRLPIVKIGDLVYSGFNMGAGENALFEIFSTIYSCGEQALLVLDEIELGLHVKAQKLFMKKLKEVCNETGTQVICTTHSREIFECLPDDARYFVETIGGKTRLIGGISPEFAFAKMGAPGGNELDIFVEDDVARSILQAILPASIRTRVTIKVIGSATAIARQLAAHYVRKDQKPTLAIFDGDQRAKDADNLGHAKKMAENAGAEFDAWYKEHVGYLPGETWPEAWLVQKAIEAKMSTAVALAVEPDAVTGVLEYALQAGKHNEFYEIAKNVGLDKQQCLERLSAAVCASFPGDFAALLKLVADQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PR5</accession>
    <name>Q63PR5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chemotaxis protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">motB</name>
        <name evidence="7" type="ordered locus">BPSL3308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009938926.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109904.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3308"/>
    <dbReference type="EnsemblBacteria" id="CAH37321">
        <property type="protein sequence ID" value="CAH37321"/>
        <property type="gene ID" value="BPSL3308"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3308"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1908"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DEKNRPM"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="169"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="340" mass="36894" checksum="14DDDDB10040CDC1" modified="2004-10-25" version="1">MSKGKDQAIIVKRVNQQKKGHHGGAWKLAYADFMTAMMAFFLLMWLLSAVTPVQLKGIAEYFNTPLKAAIFGSGDRSADDASIIKGGGRDISSLDAGTTRRTDGSTHLAERVAKKSEDDALAQAQGSLERREQVRLHDLQVKLMAAIEANPTLRQFKQQIRIDSTLMGLRIEIVDTQKRPMFAMSSDAVEPYMRDILREIGKTLNDVPNRIIVQGHTDAVPYAGGEKGYSNWELSADRANASRRELIAGGMDEAKVLRVLGLASTQNLNKADPLDPENRRISIIVLNRKSELALMRDDATTTTLSSDAAGSARLAQQITPSGAAAMPALPGASGLAVQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PT3</accession>
    <name>Q63PT3_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004198632.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109885.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3289"/>
    <dbReference type="EnsemblBacteria" id="CAH37302">
        <property type="protein sequence ID" value="CAH37302"/>
        <property type="gene ID" value="BPSL3289"/>
    </dbReference>
    <dbReference type="GeneID" id="56594007"/>
    <dbReference type="KEGG" id="bps:BPSL3289"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.1929"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="NALMFWA"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="117" mass="12736" checksum="4300B327731F5589" modified="2004-10-25" version="1">MTVILTWIINALALLIITYLVPSIHIKSFGTALIVAVVLGLINAVIRPVLILLTLPVTIVTLGLFILVVNALCFWFASSLLKGFEVSGFWSAFFGSILYSIVSWLLSALIFGQRNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q63PY8</accession>
    <name>Q63PY8_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">BPSL3236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004523127.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109830.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3236"/>
    <dbReference type="EnsemblBacteria" id="CAH37247">
        <property type="protein sequence ID" value="CAH37247"/>
        <property type="gene ID" value="BPSL3236"/>
    </dbReference>
    <dbReference type="GeneID" id="56527911"/>
    <dbReference type="KEGG" id="bps:BPSL3236"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2001"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="IVEWYRP"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH37247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="199" mass="22723" checksum="898A3F462D12BE01" modified="2004-10-25" version="1">MARTRAPDHESQREQILDLAAAKFAQTSYPSTSMTDLANASGTSKARLYHYYEGKEAILFDLLDRYTKRLMLIIAEVEGASQRRGLTEREAFAELVRAFLAEYETSHSRHVALLNDVKYLEDTQRQIVLDRQRDIVAAFARQLARAYPERISKDNQTPVTMMVFGMINWTFTWLKPGGRLGYRDFAEQVIGMIEHGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QA8</accession>
    <name>Q63QA8_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL3117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109710.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL3117"/>
    <dbReference type="EnsemblBacteria" id="CAH37127">
        <property type="protein sequence ID" value="CAH37127"/>
        <property type="gene ID" value="BPSL3117"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3117"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3566"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DELLNSW"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="112"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH37127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="286" mass="32673" checksum="706FAE44F094A6F3" modified="2004-10-25" version="1">MSPQAKREAVLAIREKVNISERRACRLVGLSRSVLHYDAKPDHENEVLAARLVKLAHERRRFGYRRLHALVEREGTHANHKRIYRLYREAGLAVRRRRKRHGVMIEREQLALPGAPNEVWSIDFVMDALSNGRRVKCLTVVDDFTKEAVDIVVDHGISGLYVARALDRAARFRGYPKAVRTDQGPEFTSRALDQWAYANGVTLKLIQAGKPTQNAYIESFNGKFRDECLNEHWFTTLAHARAVIAAWRQDYNEQRPHSALNYLAPSEFAAKHRATADAPAAFQELV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QF1</accession>
    <name>HEM1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="1">GluTR</shortName>
            <ecNumber evidence="1">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemA</name>
        <name type="ordered locus">BPSL3072</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QF1"/>
    <dbReference type="SMR" id="Q63QF1"/>
    <dbReference type="STRING" id="272560.BPSL3072"/>
    <dbReference type="EnsemblBacteria" id="CAH37083">
        <property type="protein sequence ID" value="CAH37083"/>
        <property type="gene ID" value="BPSL3072"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL3072"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114001" description="Glutamyl-tRNA reductase">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="203"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <sequence length="441" mass="48258" checksum="06D2A7C3C3F1D032" modified="2004-10-25" version="1">MGLNDSLLDMQLLTIGINHHTAPVALRERVAFPLEQIKPALSTFKSVFLGHPAPNAPEAAILSTCNRTELYCATNDRAARDAAIRWMSDYHRIPADELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKNAVRTASEAGSLGTYLNQLFQRTFAVAKEVRGTTEIGAQSVSMAAAAVRLAQRIFEQVAQQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGAKLAERFGGRAMPLADLPARMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLKDVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQADALRRAEVERARKMLARGDDPDAVLDALSQALTNKLIHGPTSALNRANGADRDSLIDLMRGFYQHAPRSSDTSDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QK6</accession>
    <name>SECA_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">BPSL3016</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">May bind 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194125.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109612.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QK6"/>
    <dbReference type="SMR" id="Q63QK6"/>
    <dbReference type="STRING" id="272560.BPSL3016"/>
    <dbReference type="EnsemblBacteria" id="CAH37028">
        <property type="protein sequence ID" value="CAH37028"/>
        <property type="gene ID" value="BPSL3016"/>
    </dbReference>
    <dbReference type="GeneID" id="56594275"/>
    <dbReference type="KEGG" id="bps:BPSL3016"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2252"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000320753" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="917"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="926"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <sequence length="931" mass="104385" checksum="1C34902576E677B6" modified="2004-10-25" version="1">MTTGFLQKIFGSRNQRLVKQYQKTVAAINALETQIETLTDDQLRGKTGEFRQRIAAGESLDKLLPEAFAVCREASRRVLKMRHFDVQMIGGMVLHYGKIAEMRTGEGKTLVATLAAYLNALAGRGVHVVTVNDYLAQRDAEWMGRLYNFLGLSVGINLSGMEHDQKQAAYAADITYGTNNEFGFDYLRDNMVYETDSRVQRPLNFAVVDEVDSILIDEARTPLIISGQAEDHTELYVRMNALPPLLERQIGEEKADGTGVEKPGDYTLDEKGRQVFLTESGHEKAERMLAEWGLIGDGESLYAPQNITLMHHVYAALRAHTLFHRDQHYVVQNDEVIIVDEFTGRLMPGRRWSDGLHQAVEAKEHVKIQSENQTLASITFQNYFRMYAKLSGMTGTADTEAYEFNEIYGLETVVIPTNRPPKRIDKQDQIYKTAKERYDAVIRDIRECHERGQPVLVGTTSIENSELLSHLLKQAGLPHEVLNAKQHAREAAIVAEAGRPKRITIATNMAGRGTDIVLGGNVEKQAAFIEADESIPADEKARRIQQLHDEWETLHEQVKTAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDPLLRIFAGDRVRAIMDRLKMPEGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVSNDQRKVIYQQRNELLEAHDIAETIGAMRHGVISEVVRQFVPAGSIEEQWDLPELEETLRNDWQLDLAIQEMVNESSSINADEILDAVTTAADEHYEAKVALVGRESFSAFERSIMLQTLDRLWREHLAALDHLRQGIHLRGYAQKNPKQEYKREAFELFAAMLDAVKQEVTRIVMNVQIQSPEQLEEAAEQIEEQGGQLGNVEFQHADFAAAAAAATAGGAVVADATAEMVGHAMSHSGPAGEVPRVGRNDPCPCGSGKKYKHCHGKLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QM1</accession>
    <name>PROB_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">BPSL3002</name>
    </gene>
    <organism>
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194262.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109597.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q63QM1"/>
    <dbReference type="SMR" id="Q63QM1"/>
    <dbReference type="STRING" id="272560.BPSL3002"/>
    <dbReference type="EnsemblBacteria" id="CAH37013">
        <property type="protein sequence ID" value="CAH37013"/>
        <property type="gene ID" value="BPSL3002"/>
    </dbReference>
    <dbReference type="GeneID" id="56594256"/>
    <dbReference type="KEGG" id="bps:BPSL3002"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2268"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000109655" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="372" mass="39233" checksum="614D38AC8CBA8C19" modified="2004-10-25" version="1">MRSIIADSKRLVVKVGSSLVTNDGRGLDHDAIGRWAAQIAALRGAGKEVVLVSSGAIAEGMQRLGWSKRPREIDELQAAAAVGQMGLAQVYESRFAEHGIRTAQILLTHADLADRERYLNARSTLLTLLRLGVVPIINENDTVVTDEIKFGDNDTLGALVANLIEGDTLVILTDQPGLFTADPRKDPGATLVAEASAGAPELEAMAGGAGSSIGRGGMLTKILAAKRAAHSGANTVIASGRERDVLVRLAAGEAIGTQLIARTARMAARKQWMADHLQVRGHVVIDAGAVDKLTAGGKSLLPIGVVAVQGVFARGEVIACVDDTGREVARGITNYSSAETKLIQRKPSGEIETVLGYMLEPELIHRDNLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QR1</accession>
    <name>Q63QR1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ordered locus">BPSL2963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194144.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109557.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2963"/>
    <dbReference type="EnsemblBacteria" id="CAH36973">
        <property type="protein sequence ID" value="CAH36973"/>
        <property type="gene ID" value="BPSL2963"/>
    </dbReference>
    <dbReference type="GeneID" id="56594212"/>
    <dbReference type="KEGG" id="bps:BPSL2963"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2312"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="QSAFFER"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAH36973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="275" mass="29764" checksum="9CE458F2E719A6EF" modified="2004-10-25" version="1">MSSTPTFIESLRTAWQRTNSLLCVGLDPEPTKFPAHLENQPDAIFDFCREIVDATAPFASAFKPQIAYFAAHRAEDQLERLIAHIHLQHPGLPVILDAKRGDIGSTAEQYAREAFERYRADAVTVNPYMGFDSIEPYLEYEDKGVVVLCRTSNPGGSDLQFLETGGRPLYQVVADLAASQWNAKTGQLALVVGATFPREIEIVRGIVGDMPLLIPGIGAQGGDVAATVAAGRTADGAGMMINSSRAILYASRGDDFADAAARTAERTRDAINAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QT0</accession>
    <name>Q63QT0_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="5">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ureidoglycolatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">allA</name>
        <name evidence="6" type="ordered locus">BPSL2944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism; (S)-allantoin degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ureidoglycolate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="5"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004527748.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109538.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2944"/>
    <dbReference type="EnsemblBacteria" id="CAH36954">
        <property type="protein sequence ID" value="CAH36954"/>
        <property type="gene ID" value="BPSL2944"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2944"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2336"/>
    <dbReference type="eggNOG" id="COG3194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DFWVIDR"/>
    <dbReference type="UniPathway" id="UPA00395"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00616">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023525">
        <property type="entry name" value="Ureidogly_lyase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="PTHR21221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017306">
        <property type="entry name" value="Ureidogly_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAH36954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="174" mass="19120" checksum="C5782F8DDA5E2E08" modified="2004-10-25" version="1">MQTLHTLRLERLTREAFAPFGDVIELAGARRILINGGTTERFHDLASIDVTEAGGRPLVSLFRAQPRAWPIEIDMMERHPLGSQAFVPLAAVARYALVVAPAGEFDPTRMRAFLAQGWQGVNYAKGVWHHPLLALDALSDFVVIDRGGAQPNCDELALDARWRLVTDDAHASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63QV4</accession>
    <name>Q63QV4_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194324.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109514.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36930">
        <property type="protein sequence ID" value="CAH36930"/>
        <property type="gene ID" value="BPSL2920"/>
    </dbReference>
    <dbReference type="GeneID" id="56593757"/>
    <dbReference type="KEGG" id="bps:BPSL2920"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2363"/>
    <dbReference type="eggNOG" id="ENOG5034AX2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HMRRRIL"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="84" mass="9600" checksum="D744B9B650359B3A" modified="2004-10-25" version="1">MHLNLTIDSRPLAIEIDDVIVGLLAIRLNLPENADPRDAISRHLSEAGGPWILDEEHMRKRVLRRLILEVADPALVIRYLMVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R79</accession>
    <name>Q63R79_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative D-glycero-d-manno-heptose 1-phosphate guanosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wcbM</name>
        <name evidence="3" type="ordered locus">BPSL2794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004194086.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109389.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2794"/>
    <dbReference type="EnsemblBacteria" id="CAH36803">
        <property type="protein sequence ID" value="CAH36803"/>
        <property type="gene ID" value="BPSL2794"/>
    </dbReference>
    <dbReference type="GeneID" id="56594716"/>
    <dbReference type="KEGG" id="bps:BPSL2794"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2514"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HRDIGNP"/>
    <dbReference type="BRENDA" id="2.7.7.71">
        <property type="organism ID" value="1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAH36803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="230" mass="24923" checksum="6EDAA1F405FE0C51" modified="2004-10-25" version="1">MREAIILAGGFGTRLRTVVSDVPKPMAPIAGRPFLEILLTRLSEKKFSRVVLSVGFMAEKIMSHFGDRFAGIDLAYSVESDPLGTGGALKATLPYCEGDHAFVFNGDTYLDLEVDELDDGWQTGGFPTIVARQVPDTGRYGRLVVDGGRVTGFAEKGVSGPGLINAGCYVLPKDILAGETAEAFSFETDFMSSAVQSRRFDVFVTRGQFIDIGVPEDFYRAQDELSGICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q63R99</accession>
    <name>Q63R99_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004550046.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109369.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2774"/>
    <dbReference type="EnsemblBacteria" id="CAH36783">
        <property type="protein sequence ID" value="CAH36783"/>
        <property type="gene ID" value="BPSL2774"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2774"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2539"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="LWCIMGF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="314" mass="35125" checksum="98F443F959CC5950" modified="2004-10-25" version="1">MKVFILHPGKASYPEIAAYRDFLGPRGFDVHDGDASAYARFDGRHDCILWCIMGFYRALPPARFVIHDYRSLSVGRLAALKDTVKRAWNAKPALRIFQNERMRDAMAFRDGIPSLLLPMGVPDWIFGIANEPAGAGPAGRFCYIGEMSRERGFHKVLAAYRAAPRTARDSLVLVGQPEPEIYEAFRHVEGLVFVGRVPQRDALKIVQRSDYAVCYFPYHRPHRFQTPTKLLEYAALGKKIICNDAPSNVDAINALGIRSHVTGAAIFDELLPLAQVRAQRNDPARLKRLEWTAVIARSGVLAHIEAAASMRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RB1</accession>
    <name>Q63RB1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tol-Pal system protein TolQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">tolQ</name>
        <name evidence="11" type="ordered locus">BPSL2761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K96243</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ExbB/TolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109357.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2761"/>
    <dbReference type="EnsemblBacteria" id="CAH36769">
        <property type="protein sequence ID" value="CAH36769"/>
        <property type="gene ID" value="BPSL2761"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2761"/>
    <dbReference type="PATRIC" id="fig|272560.6.peg.3154"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="SWTYIFR"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043213">
        <property type="term" value="P:bacteriocin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02202">
        <property type="entry name" value="TolQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014163">
        <property type="entry name" value="Tol-Pal_TolQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02796">
        <property type="entry name" value="tolQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="10">
        <location>
            <begin position="120"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAH36769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="262" mass="29006" checksum="D130B5986C614428" modified="2004-10-25" version="1">MRRASGAQPNAPPGRRRSAPAGCILARPPRRDVTQTSMNTSQDLSIISLVLNASVLAQAVMGLLLVLSLMSWTFIFRKWFAIRRARAQTERFERDFWSGGDLQALYQSAANNRHTIGALERIFESGMREFLKAKEKRLSDPALLLDGARRAMRASFQREMDVLESNLSFLASVGSVSPYIGLFGTVWGIMNSFRGLANVQQATLANVAPGIAEALVATAIGLFAAIPAVVAYNRYAHDIDRLAIRFETFIEEFSNILQRQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q63RU2</accession>
    <name>Q63RU2_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">BPSL2578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004552543.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109175.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2578"/>
    <dbReference type="EnsemblBacteria" id="CAH36586">
        <property type="protein sequence ID" value="CAH36586"/>
        <property type="gene ID" value="BPSL2578"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2578"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2785"/>
    <dbReference type="OMA" id="MNIIRLN"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAH36586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="68" mass="7367" checksum="324806C4D9A6BEDF" modified="2004-10-25" version="1">MTRLIRLTGCQRAALNGTEIDGRVFVQLDVVNTLPDGEESLTRMLISAERAGALAARDDVGPARLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q63S18</accession>
    <name>Q63S18_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">BPSL2504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004533881.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109099.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2504"/>
    <dbReference type="ESTHER" id="burma-q62m40">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CAH36510">
        <property type="protein sequence ID" value="CAH36510"/>
        <property type="gene ID" value="BPSL2504"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2504"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2878"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="FHGFSDH"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAH36510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="280" mass="30190" checksum="80984CBEBD9E138E" modified="2004-10-25" version="1">MRTADGLELACYRWPSTAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYLDDADALVASAARENTPLFLMGHSMGGAIAALYAIERAAARHASLAGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFPALKIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIEAGRAALRLPVLVYHGTADKLTEPDGSRDFGAHVGSPDRTLTLYEGNYHETMNDLERERVIGALIDWIAARVPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SB5</accession>
    <name>Q63SB5_BURPS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">BPSL2409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004192713.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_109001.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2409"/>
    <dbReference type="EnsemblBacteria" id="CAH36412">
        <property type="protein sequence ID" value="CAH36412"/>
        <property type="gene ID" value="BPSL2409"/>
    </dbReference>
    <dbReference type="GeneID" id="56596320"/>
    <dbReference type="KEGG" id="bps:BPSL2409"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.2985"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="HTFVAVT"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="39"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="356"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="389"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAH36412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="621" mass="67329" checksum="130790E5A0449C62" modified="2004-10-25" version="1">MEALTPAQRNAHNAKLASYAERPLAFLFRYIRMHPVAHVVVLVSVLAAVGCALGSQYAIKHLIDVLAAGRHHPGPLWGAFALLVGLIAADNLLWRVGGWVAAHAFVAVTGDLRRDLFQYLSGHSPTYYAEKQPGTLASRITATSNAIYTSENTMAWNVLPPCIAVMGAILMIIVVNPLMALGLLSCSGVLAIVLFKLAKLGSARHHRFAAKAAAVDGELVDVIGNMGLVRAFGMTLREQKRFSATVKAEMDARQQSLLYLEKLRLLHAVITAMLSAGLLGWALWLWDQGRATSGDIVLVSSLGFTILHGTRDLAVALVDVTQHVARLAEAVKTLLEPHGMPDRSDAIALAPRGGRVDFERVTFAYPHRRPILDHFDLHIEPGQRVGLIGKSGAGKSTVLALLQRFYDIQQGAIRIDGQDLGTITQESLRQSIALVPQDISLFHRSIYENIAYGRPDATHEEVLAAAREARCTEFIEAMPEGFETIVGDRGVKLSGGQRQRIAIARAILKNAPILLLDEATSALDSASEEAIQAALDRLMMGRTVIAIAHRLSTLRNFDRIIVMSAGKVIDDGSPGVLRERPGLYRDLLAKQHGRHLAAPAPAPAHDHSDDDDSSSDDERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SS1</accession>
    <name>Q63SS1_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">suhB</name>
        <name evidence="7" type="ordered locus">BPSL2250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K96243</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004191664.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108845.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2250"/>
    <dbReference type="EnsemblBacteria" id="CAH36252">
        <property type="protein sequence ID" value="CAH36252"/>
        <property type="gene ID" value="BPSL2250"/>
    </dbReference>
    <dbReference type="GeneID" id="56596042"/>
    <dbReference type="KEGG" id="bps:BPSL2250"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3185"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="VHQELEF"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAH36252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000605"/>
        </source>
    </evidence>
    <sequence length="267" mass="29334" checksum="6D30FADE7B848998" modified="2004-10-25" version="1">MHPMLNIAVKAARRAGQIINRASLDLDLIEIRKKQQNDFVTEVDKAAEDAIIETLKTAYPDHAILAEESGESGDASEFQWIIDPLDGTTNFIHGFPYYCVSIALAHKGVVTQAVVYDPNHNDLFTATRGRGAYLNDRRIRVGRRDRLADALIGTGFPFREKDGLDAYSRLFTEMTQACTGLRRPGAAALDLANVAAGRLDGFFEQGINVWDVAAGSLLITEAGGLVGNYTGDADFLHRREIVAANPKVYAQMIPILSRYTHTRPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-25" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q63SV5</accession>
    <name>Q63SV5_BURPS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GHMP_kinases_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">BPSL2216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Burkholderia pseudomallei (strain K96243)</name>
        <dbReference type="NCBI Taxonomy" id="272560"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Betaproteobacteria</taxon>
            <taxon>Burkholderiales</taxon>
            <taxon>Burkholderiaceae</taxon>
            <taxon>Burkholderia</taxon>
            <taxon>pseudomallei group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="14240" last="14245">
            <title>Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.</title>
            <authorList>
                <person name="Holden M.T.G."/>
                <person name="Titball R.W."/>
                <person name="Peacock S.J."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Atkins T."/>
                <person name="Crossman L.C."/>
                <person name="Pitt T."/>
                <person name="Churcher C."/>
                <person name="Mungall K."/>
                <person name="Bentley S.D."/>
                <person name="Sebaihia M."/>
                <person name="Thomson N.R."/>
                <person name="Bason N."/>
                <person name="Beacham I.R."/>
                <person name="Brooks K."/>
                <person name="Brown K.A."/>
                <person name="Brown N.F."/>
                <person name="Challis G.L."/>
                <person name="Cherevach I."/>
                <person name="Chillingworth T."/>
                <person name="Cronin A."/>
                <person name="Crosset B."/>
                <person name="Davis P."/>
                <person name="DeShazer D."/>
                <person name="Feltwell T."/>
                <person name="Fraser A."/>
                <person name="Hance Z."/>
                <person name="Hauser H."/>
                <person name="Holroyd S."/>
                <person name="Jagels K."/>
                <person name="Keith K.E."/>
                <person name="Maddison M."/>
                <person name="Moule S."/>
                <person name="Price C."/>
                <person name="Quail M.A."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rutherford K."/>
                <person name="Sanders M."/>
                <person name="Simmonds M."/>
                <person name="Songsivilai S."/>
                <person name="Stevens K."/>
                <person name="Tumapa S."/>
                <person name="Vesaratchavest M."/>
                <person name="Whitehead S."/>
                <person name="Yeats C."/>
                <person name="Barrell B.G."/>
                <person name="Oyston P.C.F."/>
                <person name="Parkhill J."/>
            </authorList>
            <dbReference type="PubMed" id="15377794"/>
            <dbReference type="DOI" id="10.1073/pnas.0403302101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K96243</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BX571965">
        <property type="protein sequence ID" value="CAH36218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004555878.1">
        <property type="nucleotide sequence ID" value="NZ_CP009538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_108811.1">
        <property type="nucleotide sequence ID" value="NC_006350.1"/>
    </dbReference>
    <dbReference type="STRING" id="272560.BPSL2216"/>
    <dbReference type="EnsemblBacteria" id="CAH36218">
        <property type="protein sequence ID" value="CAH36218"/>
        <property type="gene ID" value="BPSL2216"/>
    </dbReference>
    <dbReference type="KEGG" id="bps:BPSL2216"/>
    <dbReference type="PATRIC" id="fig|272560.51.peg.3229"/>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="DWYSTVE"/>
    <dbReference type="Proteomes" id="UP000000605">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012363">
        <property type="entry name" value="PduX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF1">
        <property type="entry name" value="PTHR43527:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="3">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type=
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